psnGPCR

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Orange: nodes, hubs and links specific of cxcr_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of cxcr_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	cxcr_off Int. Strength	cxcr_on Int. Strength	cxcr_off Hub1?	cxcr_on Hub1?	cxcr_off Hub2?	cxcr_on Hub2?	ConSurf1	ConSurf2
1	1x35	Lig	cxcr_off	100	0	Yes	No	Yes	Yes	5	0
2	1x38	1x42	cxcr_off	100	0	No	No	No	No	6	7
3	1x39	2x60	cxcr_off	100	0	Yes	Yes	Yes	No	8	5
4	1x39	Lig	cxcr_off	100	0	Yes	Yes	Yes	Yes	8	0
5	1x50	2x51	cxcr_off	100	0	Yes	No	No	No	9	7
6	1x60	2x40	cxcr_off	100	0	Yes	Yes	Yes	Yes	5	8
7	2x41	I1x51	cxcr_off	100	0	No	No	No	No	6	6
8	2x37	2x39	cxcr_off	100	0	No	No	No	No	7	8
9	2x38	I2x54	cxcr_off	100	0	No	Yes	No	No	6	5
10	2x39	3x46	cxcr_off	100	0	No	No	No	No	8	9
11	2x39	3x50	cxcr_off	100	0	No	No	Yes	No	8	9
12	2x43	7x53	cxcr_off	100	0	No	No	No	Yes	8	9
13	2x50	3x35	cxcr_off	100	0	No	No	No	Yes	9	8
14	2x52	3x31	cxcr_off	100	0	No	No	No	No	5	5
15	2x53	7x46	cxcr_off	100	0	Yes	No	No	No	6	8
16	2x56	2x60	cxcr_off	100	0	No	No	Yes	No	7	5
17	2x59	E1x50	cxcr_off	100	0	No	No	Yes	Yes	6	9
18	2x60	E1x50	cxcr_off	100	0	Yes	No	Yes	Yes	5	9
19	2x60	7x42	cxcr_off	100	0	Yes	No	Yes	Yes	5	6
20	3x22	3x26	cxcr_off	100	0	No	No	No	No	3	7
21	3x29	Lig	cxcr_off	100	0	No	No	Yes	Yes	6	0
22	3x32	6x48	cxcr_off	100	0	Yes	Yes	Yes	Yes	5	9
23	3x32	7x38	cxcr_off	100	0	Yes	Yes	Yes	No	5	5
24	3x33	3x36	cxcr_off	100	0	No	No	Yes	No	4	7
25	3x35	7x46	cxcr_off	100	0	No	Yes	No	No	8	8
26	3x36	5x43	cxcr_off	100	0	Yes	No	No	No	7	5
27	3x36	6x52	cxcr_off	100	0	Yes	No	No	No	7	8
28	3x39	6x44	cxcr_off	100	0	No	No	Yes	No	9	9
29	3x41	5x50	cxcr_off	100	0	No	No	Yes	No	6	9
30	3x43	6x41	cxcr_off	100	0	No	No	No	No	8	8
31	3x43	6x44	cxcr_off	100	0	No	No	Yes	No	8	9
32	3x46	6x37	cxcr_off	100	0	No	No	No	No	9	7
33	3x48	3x52	cxcr_off	100	0	No	No	Yes	No	6	5
34	3x49	I2x54	cxcr_off	100	0	Yes	Yes	No	No	8	5
35	3x50	3x53	cxcr_off	100	0	Yes	No	No	No	9	8
36	3x50	6x37	cxcr_off	100	0	Yes	No	No	No	9	7
37	3x51	3x52	cxcr_off	100	0	Yes	Yes	Yes	No	8	5
38	3x52	I2x51	cxcr_off	100	0	Yes	No	No	No	5	5
39	5x36	E2x52	cxcr_off	100	0	No	No	Yes	Yes	4	3
40	5x36	E2	cxcr_off	100	0	No	No	Yes	Yes	4	3
41	5x40	6x62	cxcr_off	100	0	Yes	No	Yes	No	3	2
42	5x43	6x52	cxcr_off	100	0	No	No	No	No	5	8
43	5x461	5x50	cxcr_off	100	0	No	No	Yes	No	5	9
44	5x54	6x41	cxcr_off	100	0	No	No	No	No	8	8
45	6x36	7x53	cxcr_off	100	0	No	No	No	Yes	8	9
46	6x44	7x45	cxcr_off	100	0	Yes	No	No	No	9	9
47	6x48	6x51	cxcr_off	100	0	Yes	Yes	Yes	Yes	9	6
48	6x61	7x30	cxcr_off	100	0	No	No	No	No	3	4
49	6x62	E3	cxcr_off	100	0	Yes	No	Yes	Yes	2	2
50	7x27	7x31	cxcr_off	100	0	No	No	No	No	1	4
51	7x42	Lig	cxcr_off	100	0	Yes	Yes	Yes	Yes	6	0
52	7x49	7x50	cxcr_off	100	0	No	No	No	No	9	9
53	7x53	8x50	cxcr_off	100	0	No	Yes	Yes	Yes	9	8
54	8x50	8x53	cxcr_off	100	0	Yes	Yes	No	No	8	5
55	1x24	7x28	cxcr_off	100	0	No	No	Yes	No	0	3
56	1x24	Lig	cxcr_off	100	0	No	No	Yes	Yes	0	0
57	2x43	7x49	cxcr_off	100	0	No	No	No	No	8	9
58	2x45	4x45	cxcr_off	100	0	No	No	No	No	9	5
59	2x63	Lig	cxcr_off	100	0	No	No	Yes	Yes	5	0
60	3x32	3x36	cxcr_off	100	0	Yes	Yes	Yes	No	5	7
61	3x37	5x46	cxcr_off	100	0	Yes	Yes	No	No	6	5
62	3x45	4x40	cxcr_off	100	0	No	No	No	No	7	4
63	4x64	5x35	cxcr_off	100	0	No	No	No	No	5	4
64	5x34	E2	cxcr_off	100	0	No	No	Yes	Yes	1	3
65	6x44	6x45	cxcr_off	100	0	Yes	No	No	No	9	5
66	6x64	E3	cxcr_off	100	0	No	No	Yes	Yes	1	2
67	7x31	Lig	cxcr_off	100	0	No	No	Yes	Yes	4	0
68	E2x52	Lig	cxcr_off	100	0	Yes	Yes	Yes	Yes	3	0
69	5x40	Lig	cxcr_off	100	0	Yes	No	Yes	Yes	3	0
70	2x49	4x50	cxcr_off	66.6667	0	No	No	Yes	No	8	9
71	1x50	2x47	cxcr_off	50	0	Yes	No	No	No	9	9
72	2x54	2x57	cxcr_off	50	0	No	No	No	Yes	6	8
73	2x40	I1x51	cxcr_off	50	0	Yes	Yes	No	No	8	6
74	1x30	7x32	cxcr_off	50	0	No	No	No	No	0	2
75	2x59	3x24	cxcr_off	50	0	No	No	No	No	6	6
76	3x50	6x32	cxcr_off	50	0	Yes	No	No	No	9	0
77	8x49	8x53	cxcr_off	50	0	No	No	No	No	6	5
78	2x42	4x41	cxcr_off	50	0	Yes	Yes	No	No	7	4
79	1x58	I1x48	cxcr_off	50	0	No	No	No	No	4	5
80	3x34	4x57	cxcr_off	50	0	No	No	No	No	6	7
81	5x58	5x62	cxcr_off	50	0	Yes	Yes	No	No	8	5
82	3x52	I2x53	cxcr_off	66.6667	0	Yes	No	No	No	5	6
83	6x47	7x48	cxcr_off	16.6667	0	No	No	No	No	9	6
84	1x54	2x51	cxcr_off	50	0	No	No	No	No	7	7
85	6x43	7x48	cxcr_off	50	0	No	No	No	No	6	6
86	7x23	7x24	cxcr_off	50	0	No	No	No	No	5	8
87	1x56	1x60	cxcr_off	33.3333	0	No	No	Yes	Yes	7	5
88	1x39	7x39	cxcr_off	50	0	Yes	Yes	No	No	8	5
89	3x51	5x61	cxcr_off	50	0	Yes	Yes	Yes	No	8	8
90	3x43	6x40	cxcr_off	0	0	No	No	No	No	8	8
91	7x32	7x33	cxcr_off	50	0	No	No	No	No	2	5
92	5x45	5x49	cxcr_off	50	0	No	No	No	No	5	6
93	1x27	7x28	cxcr_off	50	0	No	No	Yes	No	0	3
94	3x52	I2x57	cxcr_off	50	0	Yes	No	Yes	Yes	5	6
95	2x37	I2x55	cxcr_off	50	0	No	No	No	No	7	4
96	1x46	7x47	cxcr_off	0	0	No	No	No	No	8	8
97	6x35	7x56	cxcr_off	50	0	No	No	No	No	5	7
98	I2x55	I2x56	cxcr_off	50	0	No	No	No	No	4	4
99	1x36	2x64	cxcr_off	50	0	No	No	No	No	4	5
100	5x41	5x45	cxcr_off	0	0	No	No	No	No	4	5
101	5x47	5x51	cxcr_off	50	0	No	No	No	No	8	7
102	2x66	E1x51	cxcr_off	50	0	No	No	No	No	4	3
103	3x23	3x26	cxcr_off	50	0	No	No	No	No	1	7
104	3x48	5x53	cxcr_off	50	0	No	No	No	No	6	7
105	5x44	6x59	cxcr_off	50	0	No	No	No	No	4	5
106	1x25	NT	cxcr_off	16.6667	0	No	No	No	Yes	0	0
107	3x27	3x31	cxcr_off	50	0	No	No	No	No	5	5
108	4x39	4x43	cxcr_off	16.6667	0	No	No	No	No	0	4
109	6x35	6x36	cxcr_off	16.6667	0	No	No	No	No	5	8
110	5x33	Lig	cxcr_off	16.6667	0	No	No	Yes	Yes	2	0
111	8x51	8x54	cxcr_off	50	0	No	No	No	No	8	6
112	1x38	7x40	cxcr_off	16.6667	0	No	No	No	No	6	8
113	6x63	E3	cxcr_off	16.6667	0	No	No	Yes	Yes	1	2
114	5x61	6x34	cxcr_off	0	0	Yes	No	No	No	8	0
115	1x48	1x52	cxcr_off	0	0	No	No	No	No	5	7
116	5x48	5x52	cxcr_off	0	0	No	No	No	No	4	4
117	4x51	4x55	cxcr_off	0	0	No	No	No	No	4	5
118	1x29	1x33	cxcr_off	16.6667	0	No	No	No	No	0	4
119	I1x49	I1x50	cxcr_off	16.6667	0	No	No	No	No	6	7
120	3x21	E1x50	cxcr_off	0	0	No	No	Yes	Yes	8	9
121	6x33	6x36	cxcr_off	16.6667	0	No	No	No	No	0	8
122	5x58	6x38	cxcr_off	16.6667	0	Yes	Yes	No	No	8	5
123	7x47	7x51	cxcr_off	16.6667	0	No	No	No	No	8	6
124	4x43	4x47	cxcr_off	0	0	No	No	No	No	4	5
125	6x31	6x33	cxcr_off	16.6667	0	No	No	No	No	0	0
126	1x44	1x48	cxcr_off	0	0	No	No	No	No	5	5
127	7x28	7x29	cxcr_off	0	0	Yes	No	No	No	3	3
128	I1x48	I1x49	cxcr_off	0	0	No	No	No	No	5	6
129	8x51	8x52	cxcr_off	0	0	No	No	No	No	8	5
130	1x51	2x51	cxcr_off	0	0	No	No	No	No	4	7
131	6x32	I2x50	cxcr_off	0	0	No	No	No	No	0	7
132	6x30	6x32	cxcr_off	0	0	No	Yes	No	No	0	0
133	1x34	1x38	Shared	100	50	No	No	No	No	4	6
134	1x35	1x39	Shared	100	100	Yes	No	Yes	Yes	5	8
135	1x36	2x65	Shared	100	0	No	No	No	No	4	5
136	1x42	7x43	Shared	100	100	No	No	No	No	7	5
137	1x43	1x47	Shared	100	100	No	No	No	Yes	7	6
138	1x43	2x58	Shared	100	100	No	No	No	No	7	9
139	1x45	7x47	Shared	100	100	No	No	No	No	6	8
140	1x49	7x50	Shared	100	25	No	No	No	No	7	9
141	1x50	2x50	Shared	100	100	Yes	No	No	No	9	9
142	1x53	2x47	Shared	100	100	No	Yes	No	No	9	9
143	1x56	8x54	Shared	100	50	No	No	No	No	7	6
144	1x57	2x40	Shared	100	37.5	No	No	Yes	Yes	7	8
145	1x57	2x44	Shared	100	25	No	No	No	No	7	6
146	1x58	2x44	Shared	100	0	No	No	No	No	4	6
147	1x60	8x53	Shared	100	25	Yes	Yes	No	No	5	5
148	2x37	2x40	Shared	100	100	No	No	Yes	Yes	7	8
149	2x38	3x49	Shared	100	100	No	Yes	Yes	Yes	6	8
150	2x41	4x42	Shared	100	100	No	No	No	Yes	6	8
151	2x42	3x45	Shared	100	100	Yes	Yes	No	No	7	7
152	2x42	3x46	Shared	100	100	Yes	Yes	No	No	7	9
153	2x45	4x46	Shared	100	100	No	No	No	No	9	7
154	2x45	4x50	Shared	100	100	No	No	Yes	No	9	9
155	2x46	3x42	Shared	100	100	No	Yes	No	No	9	8
156	2x50	7x46	Shared	100	100	No	No	No	No	9	8
157	2x53	3x32	Shared	100	100	Yes	No	Yes	Yes	6	5
158	2x53	3x35	Shared	100	100	Yes	No	No	Yes	6	8
159	2x53	7x42	Shared	100	100	Yes	No	Yes	Yes	6	6
160	2x56	3x31	Shared	100	100	No	No	No	No	7	5
161	2x57	7x42	Shared	100	100	No	Yes	Yes	Yes	8	6
162	2x59	E1x52	Shared	100	100	No	No	No	Yes	6	7
163	2x60	3x28	Shared	100	50	Yes	No	No	No	5	5
164	2x60	Lig	Shared	100	100	Yes	No	Yes	Yes	5	0
165	2x62	E1x52	Shared	100	50	No	No	No	Yes	4	7
166	2x63	E1x50	Shared	100	100	No	No	Yes	Yes	5	9
167	E1x49	E1x51	Shared	100	100	No	No	No	No	3	3
168	E1x49	E2	Shared	100	100	No	No	Yes	Yes	3	3
169	E1x50	E1x52	Shared	100	100	Yes	Yes	No	Yes	9	7
170	3x25	E1x50	Shared	100	100	No	No	Yes	Yes	9	9
171	E1x50	E2	Shared	100	100	Yes	Yes	Yes	Yes	9	3
172	E1x50	E2x50	Shared	100	100	Yes	Yes	No	No	9	9
173	3x22	E2	Shared	100	100	No	No	Yes	Yes	3	3
174	3x25	E2x50	Shared	100	100	No	No	No	No	9	9
175	3x29	4x65	Shared	100	100	No	No	No	Yes	6	5
176	3x30	4x57	Shared	100	50	No	No	No	No	5	7
177	3x30	4x62	Shared	100	100	No	No	No	No	5	4
178	3x32	7x42	Shared	100	100	Yes	Yes	Yes	Yes	5	6
179	3x32	Lig	Shared	100	100	Yes	Yes	Yes	Yes	5	0
180	3x33	4x61	Shared	100	100	No	No	No	Yes	4	4
181	3x36	3x37	Shared	100	100	Yes	No	Yes	Yes	7	6
182	3x36	6x48	Shared	100	100	Yes	No	Yes	Yes	7	9
183	3x37	4x56	Shared	100	100	Yes	Yes	No	Yes	6	5
184	3x37	5x43	Shared	100	100	Yes	Yes	No	No	6	5
185	3x38	4x50	Shared	100	100	No	No	Yes	No	7	9
186	3x40	5x50	Shared	100	0	No	No	Yes	No	8	9
187	3x41	4x49	Shared	100	50	No	No	No	No	6	7
188	3x42	4x49	Shared	100	100	No	No	No	No	8	7
189	3x47	5x54	Shared	100	100	No	No	No	No	9	8
190	3x47	5x58	Shared	100	100	No	No	Yes	Yes	9	8
191	3x48	5x57	Shared	100	0	No	No	No	No	6	7
192	3x51	3x55	Shared	100	100	Yes	Yes	No	No	8	7
193	3x51	3x56	Shared	100	100	Yes	Yes	No	Yes	8	6
194	3x51	5x57	Shared	100	100	Yes	Yes	No	No	8	7
195	3x51	5x60	Shared	100	100	Yes	Yes	No	No	8	4
196	3x54	5x61	Shared	100	100	No	No	Yes	No	8	8
197	3x55	3x56	Shared	100	100	No	No	No	Yes	7	6
198	I2x52	I2x55	Shared	100	25	No	Yes	No	No	4	4
199	4x52	4x56	Shared	100	25	No	No	No	Yes	4	5
200	4x60	5x39	Shared	100	25	No	No	No	No	7	5
201	4x61	E2x52	Shared	100	100	No	Yes	Yes	Yes	4	3
202	4x63	4x64	Shared	100	100	No	No	No	No	4	5
203	4x64	E2	Shared	100	100	No	No	Yes	Yes	5	3
204	4x65	E2x52	Shared	100	100	No	Yes	Yes	Yes	5	3
205	E2	E2	Shared	100	100	Yes	Yes	Yes	Yes	3	3
206	E2	E2x51	Shared	100	100	Yes	Yes	No	No	3	3
207	E2	E2x52	Shared	100	100	Yes	Yes	Yes	Yes	3	3
208	5x35	E2	Shared	100	100	No	No	Yes	Yes	4	3
209	5x40	6x58	Shared	100	100	Yes	No	No	Yes	3	5
210	5x40	6x59	Shared	100	100	Yes	No	No	No	3	5
211	5x44	6x56	Shared	100	12.5	No	No	No	No	4	5
212	5x47	6x52	Shared	100	100	No	No	No	No	8	8
213	5x56	5x60	Shared	100	100	No	No	No	No	4	4
214	5x58	6x41	Shared	100	100	Yes	Yes	No	No	8	8
215	6x39	7x52	Shared	100	0	No	No	No	No	5	8
216	6x44	6x48	Shared	100	100	Yes	No	Yes	Yes	9	9
217	6x47	7x45	Shared	100	100	No	No	No	No	9	9
218	6x48	7x41	Shared	100	100	Yes	Yes	No	No	9	8
219	6x48	7x45	Shared	100	100	Yes	Yes	No	No	9	9
220	6x51	6x55	Shared	100	100	Yes	Yes	No	No	6	5
221	6x51	7x37	Shared	100	100	Yes	Yes	No	No	6	7
222	6x51	7x38	Shared	100	100	Yes	Yes	Yes	No	6	5
223	6x54	7x34	Shared	100	37.5	No	No	No	No	4	5
224	6x58	6x62	Shared	100	100	No	Yes	Yes	No	5	2
225	6x60	E3	Shared	100	100	No	No	Yes	Yes	4	2
226	6x61	E3	Shared	100	100	No	No	Yes	Yes	3	2
227	7x26	E3	Shared	100	100	No	No	Yes	Yes	3	2
228	7x27	E3	Shared	100	25	No	No	Yes	Yes	1	2
229	7x34	Lig	Shared	100	100	No	No	Yes	Yes	5	0
230	7x35	Lig	Shared	100	62.5	No	No	Yes	Yes	4	0
231	7x38	Lig	Shared	100	100	Yes	No	Yes	Yes	5	0
232	8x54	8x55	Shared	100	25	No	No	No	No	6	2
233	Lig	NT	Shared	100	100	Yes	Yes	No	Yes	0	0
234	1x39	7x42	Shared	100	100	Yes	Yes	Yes	Yes	8	6
235	1x50	7x50	Shared	100	100	Yes	No	No	No	9	9
236	2x38	I2x57	Shared	100	100	No	Yes	Yes	Yes	6	6
237	2x42	3x49	Shared	100	100	Yes	Yes	Yes	Yes	7	8
238	2x46	7x49	Shared	100	100	No	Yes	No	No	9	9
239	2x60	3x32	Shared	100	100	Yes	No	Yes	Yes	5	5
240	3x49	I2x57	Shared	100	100	Yes	Yes	Yes	Yes	8	6
241	3x53	I2x57	Shared	100	100	No	No	Yes	Yes	8	6
242	4x38	4x42	Shared	100	25	No	No	No	Yes	0	8
243	E2	Lig	Shared	100	100	Yes	Yes	Yes	Yes	3	0
244	E2x51	Lig	Shared	100	100	No	No	Yes	Yes	3	0
245	5x45	5x48	Shared	100	25	No	No	No	No	5	4
246	6x58	Lig	Shared	100	100	No	Yes	Yes	Yes	5	0
247	6x62	Lig	Shared	100	100	Yes	No	Yes	Yes	2	0
248	7x27	Lig	Shared	100	100	No	No	Yes	Yes	1	0
249	7x33	7x37	Shared	100	25	No	No	No	No	5	7
250	7x38	7x42	Shared	100	100	Yes	No	Yes	Yes	5	6
251	Lig	Lig	Shared	100	100	Yes	Yes	Yes	Yes	0	0
252	6x57	7x30	Shared	50	0	No	No	No	No	5	4
253	6x49	6x50	Shared	66.6667	100	No	No	No	No	5	9
254	1x43	2x57	Shared	50	25	No	No	No	Yes	7	8
255	4x59	4x60	Shared	50	0	No	No	No	No	4	7
256	3x34	4x50	Shared	50	0	No	No	Yes	No	6	9
257	2x42	4x45	Shared	66.6667	25	Yes	Yes	No	No	7	5
258	5x39	E2	Shared	50	100	No	No	Yes	Yes	5	3
259	1x39	2x61	Shared	66.6667	100	Yes	Yes	No	No	8	7
260	6x50	7x37	Shared	50	100	No	No	No	No	9	7
261	6x40	7x52	Shared	50	62.5	No	No	No	No	8	8
262	7x23	7x25	Shared	50	25	No	No	No	No	5	2
263	1x30	1x34	Shared	50	100	No	No	No	No	0	4
264	1x46	2x54	Shared	33.3333	25	No	No	No	No	8	6
265	7x24	NT	Shared	50	100	No	No	No	Yes	8	0
266	1x26	7x28	Shared	50	25	No	No	Yes	No	0	3
267	1x30	7x36	Shared	50	25	No	No	No	No	0	6
268	1x31	1x35	Shared	50	100	No	No	Yes	No	0	5
269	3x55	5x64	Shared	50	100	No	No	No	No	7	0
270	3x44	5x53	Shared	16.6667	25	No	No	No	No	7	7
271	4x42	4x43	Shared	16.6667	25	No	Yes	No	No	8	4
272	I2	I2x57	Shared	50	25	No	No	Yes	Yes	4	6
273	4x48	4x52	Shared	50	25	No	No	No	No	3	4
274	4x56	5x42	Shared	50	100	No	Yes	No	No	5	3
275	4x40	4x44	Shared	50	25	No	No	No	No	4	2
276	1x35	2x64	Shared	0	37.5	Yes	No	No	No	5	5
277	7x56	8x47	Shared	50	0	No	No	No	No	7	8
278	6x38	6x42	Shared	0	0	No	No	No	No	5	5
279	1x59	1x60	Shared	50	25	No	Yes	Yes	Yes	5	5
280	4x51	4x52	Shared	50	25	No	No	No	No	4	4
281	5x49	5x50	Shared	0	50	No	No	Yes	No	6	9
282	1x54	2x48	Shared	16.6667	25	No	No	No	No	7	6
283	3x38	4x53	Shared	0	100	No	No	No	No	7	8
284	5x32	E2	Shared	50	100	No	No	Yes	Yes	4	3
285	7x55	8x50	Shared	16.6667	100	No	No	Yes	Yes	7	8
286	1x47	2x55	Shared	0	25	No	Yes	No	No	6	5
287	8x48	8x52	Shared	50	25	No	No	No	No	5	5
288	7x54	8x50	Shared	50	100	No	No	Yes	Yes	7	8
289	5x37	6x62	Shared	0	100	No	No	Yes	No	1	2
290	3x34	4x54	Shared	0	25	No	No	No	No	6	4
291	6x49	6x53	Shared	0	50	No	No	No	No	5	6
292	6x30	I3	Shared	16.6667	25	No	Yes	No	No	0	0
293	1x48	1x49	Shared	0	25	No	No	No	No	5	7
294	1x41	1x45	Shared	0	25	No	No	No	No	5	6
295	5x35	5x38	Shared	0	0	No	No	No	No	4	3
296	5x61	5x65	Shared	16.6667	0	Yes	No	No	No	8	0
297	1x37	1x40	Shared	0	0	No	No	No	No	5	6
298	1x32	2x65	Shared	0	25	No	Yes	No	No	0	5
299	1x37	1x41	Shared	0	0	No	No	No	No	5	5
300	1x55	1x59	Shared	0	50	No	No	No	Yes	3	5
301	1x28	1x32	Shared	0	25	No	No	No	Yes	0	0
302	1x32	1x33	Shared	0	50	No	Yes	No	No	0	4
303	NT	NT	cxcr_on	0	100	No	Yes	No	Yes	0	0
304	1x27	7x31	cxcr_on	0	100	No	No	No	No	0	4
305	1x39	2x57	cxcr_on	0	100	Yes	Yes	No	Yes	8	8
306	1x46	1x50	cxcr_on	0	100	No	No	Yes	No	8	9
307	1x53	7x54	cxcr_on	0	100	No	Yes	No	No	9	7
308	1x53	8x50	cxcr_on	0	100	No	Yes	Yes	Yes	9	8
309	1x56	8x50	cxcr_on	0	100	No	No	Yes	Yes	7	8
310	1x57	8x50	cxcr_on	0	100	No	No	Yes	Yes	7	8
311	1x59	8x57	cxcr_on	0	100	No	Yes	No	No	5	0
312	2x38	4x42	cxcr_on	0	100	No	Yes	No	Yes	6	8
313	2x42	4x42	cxcr_on	0	100	Yes	Yes	No	Yes	7	8
314	2x46	3x43	cxcr_on	0	100	No	Yes	No	No	9	8
315	2x50	7x49	cxcr_on	0	100	No	No	No	No	9	9
316	2x52	3x35	cxcr_on	0	100	No	No	No	Yes	5	8
317	2x63	E2	cxcr_on	0	100	No	No	Yes	Yes	5	3
318	E1x51	E1x52	cxcr_on	0	100	No	No	No	Yes	3	7
319	3x24	E1x52	cxcr_on	0	100	No	No	No	Yes	6	7
320	3x29	4x61	cxcr_on	0	100	No	No	No	Yes	6	4
321	3x31	3x35	cxcr_on	0	100	No	No	No	Yes	5	8
322	3x33	3x37	cxcr_on	0	100	No	No	Yes	Yes	4	6
323	3x43	7x53	cxcr_on	0	100	No	No	No	Yes	8	9
324	3x46	3x50	cxcr_on	0	100	No	No	Yes	No	9	9
325	3x46	7x53	cxcr_on	0	100	No	No	No	Yes	9	9
326	3x47	5x57	cxcr_on	0	100	No	No	No	No	9	7
327	3x50	5x58	cxcr_on	0	100	Yes	No	Yes	Yes	9	8
328	3x50	7x53	cxcr_on	0	100	Yes	No	No	Yes	9	9
329	3x56	I2x52	cxcr_on	0	100	No	Yes	No	Yes	6	4
330	4x61	4x65	cxcr_on	0	100	No	Yes	No	Yes	4	5
331	4x65	E2x50	cxcr_on	0	100	No	Yes	No	No	5	9
332	5x39	E2x52	cxcr_on	0	100	No	No	Yes	Yes	5	3
333	5x36	Lig	cxcr_on	0	100	No	No	Yes	Yes	4	0
334	5x37	6x59	cxcr_on	0	100	No	No	No	No	1	5
335	5x37	6x63	cxcr_on	0	100	No	No	No	No	1	1
336	5x40	6x55	cxcr_on	0	100	Yes	No	No	No	3	5
337	5x44	6x52	cxcr_on	0	100	No	No	No	No	4	8
338	5x47	6x49	cxcr_on	0	100	No	No	No	No	8	5
339	5x54	5x58	cxcr_on	0	100	No	No	Yes	Yes	8	8
340	5x54	6x44	cxcr_on	0	100	No	No	Yes	No	8	9
341	5x58	6x37	cxcr_on	0	100	Yes	Yes	No	No	8	7
342	5x58	6x40	cxcr_on	0	100	Yes	Yes	No	No	8	8
343	5x62	6x34	cxcr_on	0	100	No	No	No	No	5	0
344	5x62	6x37	cxcr_on	0	100	No	No	No	No	5	7
345	5x68	6x30	cxcr_on	0	100	No	No	No	Yes	0	0
346	6x31	6x35	cxcr_on	0	100	No	No	No	No	0	5
347	6x36	7x56	cxcr_on	0	100	No	No	No	No	8	7
348	6x40	7x53	cxcr_on	0	100	No	No	No	Yes	8	9
349	6x51	6x52	cxcr_on	0	100	Yes	Yes	No	No	6	8
350	6x51	Lig	cxcr_on	0	100	Yes	Yes	Yes	Yes	6	0
351	7x45	7x49	cxcr_on	0	100	No	No	No	No	9	9
352	E3	E3	cxcr_on	0	100	Yes	Yes	Yes	Yes	2	2
353	7x28	NT	cxcr_on	0	100	Yes	No	No	Yes	3	0
354	1x31	7x32	cxcr_on	0	100	No	No	No	No	0	2
355	3x40	6x48	cxcr_on	0	100	No	No	Yes	Yes	8	9
356	5x36	E2x51	cxcr_on	0	100	No	No	No	No	4	3
357	5x31	5x34	cxcr_on	0	100	No	No	No	No	0	1
358	I2x51	I2x52	cxcr_on	0	100	No	No	No	Yes	5	4
359	1x24	7x31	cxcr_on	0	100	No	No	No	No	0	4
360	3x56	I2x53	cxcr_on	0	25	No	Yes	No	No	6	6
361	5x62	6x38	cxcr_on	0	25	No	No	No	No	5	5
362	1x52	7x55	cxcr_on	0	50	No	No	No	No	7	7
363	6x30	6x31	cxcr_on	0	50	No	Yes	No	No	0	0
364	1x30	1x33	cxcr_on	0	25	No	No	No	No	0	4
365	5x55	6x41	cxcr_on	0	50	No	No	No	No	5	8
366	3x34	3x35	cxcr_on	0	25	No	No	No	Yes	6	8
367	4x56	5x46	cxcr_on	0	50	No	Yes	No	No	5	5
368	2x48	2x52	cxcr_on	0	50	No	No	No	No	6	5
369	5x66	5x67	cxcr_on	0	25	No	No	No	No	0	0
370	5x51	6x44	cxcr_on	0	50	No	No	Yes	No	7	9
371	3x26	4x62	cxcr_on	0	25	No	No	No	No	7	4
372	2x39	3x49	cxcr_on	0	50	No	No	Yes	Yes	8	8
373	3x33	4x57	cxcr_on	0	25	No	No	No	No	4	7
374	5x51	6x45	cxcr_on	0	50	No	No	No	No	7	5
375	6x64	Lig	cxcr_on	0	25	No	No	Yes	Yes	1	0
376	1x60	I1x49	cxcr_on	0	50	Yes	Yes	No	No	5	6
377	1x53	7x50	cxcr_on	0	37.5	No	Yes	No	No	9	9
378	5x66	6x34	cxcr_on	0	50	No	No	No	No	0	0
379	3x52	3x56	cxcr_on	0	37.5	Yes	No	No	Yes	5	6
380	5x41	6x59	cxcr_on	0	25	No	No	No	No	4	5
381	8x60	8x61	cxcr_on	0	50	No	No	No	No	0	0
382	2x40	2x43	cxcr_on	0	25	Yes	Yes	No	No	8	8
383	6x58	7x30	cxcr_on	0	50	No	Yes	No	No	5	4
384	3x44	5x50	cxcr_on	0	37.5	No	No	Yes	No	7	9
385	1x29	1x32	cxcr_on	0	25	No	No	No	Yes	0	0
386	1x42	7x47	cxcr_on	0	12.5	No	No	No	No	7	8
387	4x41	4x44	cxcr_on	0	25	No	No	No	No	4	2
388	7x43	7x48	cxcr_on	0	25	No	No	No	No	5	6
389	1x32	NT	cxcr_on	0	25	No	Yes	No	Yes	0	0
390	1x42	2x57	cxcr_on	0	0	No	No	No	Yes	7	8
391	I2x52	I2x56	cxcr_on	0	25	No	Yes	No	No	4	4
392	5x33	5x36	cxcr_on	0	25	No	No	No	No	2	4
393	5x58	5x61	cxcr_on	0	37.5	Yes	Yes	Yes	No	8	8
394	1x27	7x32	cxcr_on	0	25	No	No	No	No	0	2
395	2x44	I1x51	cxcr_on	0	25	No	No	No	No	6	6
396	6x43	7x52	cxcr_on	0	0	No	No	No	No	6	8
397	3x56	I2x54	cxcr_on	0	25	No	Yes	No	No	6	5
398	5x47	5x48	cxcr_on	0	50	No	No	No	No	8	4
399	2x49	3x38	cxcr_on	0	0	No	No	No	No	8	7
400	1x47	2x51	cxcr_on	0	25	No	Yes	No	No	6	7
401	7x40	7x43	cxcr_on	0	25	No	No	No	No	8	5
402	2x65	2x66	cxcr_on	0	25	No	No	No	No	5	4
403	1x38	7x39	cxcr_on	0	0	No	No	No	No	6	5
404	7x25	7x29	cxcr_on	0	25	No	No	No	No	2	3
405	1x59	8x61	cxcr_on	0	25	No	Yes	No	No	5	0
406	2x38	4x41	cxcr_on	0	37.5	No	Yes	No	No	6	4
407	8x48	8x51	cxcr_on	0	12.5	No	No	No	No	5	8
408	3x37	5x461	cxcr_on	0	0	Yes	Yes	No	No	6	5
409	6x32	8x51	cxcr_on	0	25	No	No	No	No	0	8
410	5x65	6x30	cxcr_on	0	25	No	No	No	Yes	0	0
411	2x46	3x39	cxcr_on	0	0	No	Yes	No	No	9	9
412	2x40	8x53	cxcr_on	0	25	Yes	Yes	No	No	8	5
413	5x52	5x56	cxcr_on	0	25	No	No	No	No	4	4
414	5x65	6x33	cxcr_on	0	0	No	No	No	No	0	0
415	7x23	7x26	cxcr_on	0	12.5	No	No	No	No	5	3
416	5x31	E2	cxcr_on	0	25	No	No	Yes	Yes	0	3
417	I2x52	I2x58	cxcr_on	0	25	No	Yes	No	No	4	0
418	7x51	7x55	cxcr_on	0	0	No	No	No	No	6	7
419	5x60	5x63	cxcr_on	0	0	No	No	No	No	4	3
420	6x29	6x32	cxcr_on	0	0	No	No	No	No	0	0
421	4x39	4x44	cxcr_on	0	25	No	No	No	No	0	2
422	8x54	8x58	cxcr_on	0	0	No	No	No	No	6	0
423	1x60	8x56	cxcr_on	0	12.5	Yes	Yes	No	No	5	0
424	6x32	7x56	cxcr_on	0	0	No	No	No	No	0	7
425	3x21	E1x52	cxcr_on	0	0	No	No	No	Yes	8	7
426	3x24	3x27	cxcr_on	0	0	No	No	No	No	6	5
427	2x40	I1x50	cxcr_on	0	0	Yes	Yes	No	No	8	7
428	8x52	8x55	cxcr_on	0	25	No	No	No	No	5	2
429	6x46	6x47	cxcr_on	0	12.5	No	No	No	No	5	9
430	5x55	5x59	cxcr_on	0	0	No	No	No	No	5	3
431	CT	I1x48	cxcr_on	0	0	No	No	No	No	0	5
432	4x55	4x56	cxcr_on	0	0	No	No	No	Yes	5	5
433	1x25	1x29	cxcr_on	0	12.5	No	No	No	No	0	0
434	3x23	3x27	cxcr_on	0	0	No	No	No	No	1	5
435	1x59	CT	cxcr_on	0	0	No	Yes	No	No	5	0
436	1x51	1x54	cxcr_on	0	0	No	No	No	No	4	7
437	8x49	8x50	cxcr_on	0	0	No	No	Yes	Yes	6	8
438	8x55	8x59	cxcr_on	0	12.5	No	No	No	No	2	0
439	4x47	4x48	cxcr_on	0	0	No	No	No	No	5	3
440	1x44	1x47	cxcr_on	0	0	No	No	No	Yes	5	6
441	4x41	I2x59	cxcr_on	0	0	No	No	No	No	4	0

Orange: nodes, hubs and links specific of cxcr_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of cxcr_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	cxcr_off Avg Int. Strength	cxcr_on Avg Int. Strength	cxcr_off Num Of Links	cxcr_on Num Of Links	ConSurf
1	1x35	cxcr_off	0	0	4	3	5
2	1x50	cxcr_off	0	0	4	3	9
3	2x53	cxcr_off	50	25	4	3	6
4	2x60	cxcr_off	100	37.5	7	3	5
5	3x36	cxcr_off	50	25	6	2	7
6	3x50	cxcr_off	0	0	4	3	9
7	3x52	cxcr_off	50	0	5	1	5
8	4x50	cxcr_off	0	0	4	3	9
9	5x40	cxcr_off	50	25	4	3	3
10	5x50	cxcr_off	0	0	4	3	9
11	5x61	cxcr_off	0	0	4	3	8
12	6x44	cxcr_off	100	25	5	3	9
13	6x62	cxcr_off	0	0	5	3	2
14	7x28	cxcr_off	0	0	4	2	3
15	7x38	cxcr_off	50	0	4	3	5
16	1x39	Shared	83.3333	50	6	4	8
17	1x60	Shared	50	0	4	4	5
18	2x40	Shared	50	0	4	5	8
19	2x42	Shared	100	75	5	5	7
20	E1x50	Shared	100	75	8	5	9
21	3x32	Shared	100	37.5	7	4	5
22	3x37	Shared	50	50	4	5	6
23	3x49	Shared	16.6667	50	4	4	8
24	3x51	Shared	83.3333	87.5	6	4	8
25	I2x57	Shared	50	25	5	4	6
26	E2	Shared	100	100	14	14	3
27	E2x52	Shared	100	25	5	4	3
28	5x58	Shared	0	100	4	7	8
29	6x48	Shared	100	75	6	5	9
30	6x51	Shared	100	75	4	5	6
31	E3	Shared	50	50	7	6	2
32	7x42	Shared	100	75	7	5	6
33	8x50	Shared	50	75	4	6	8
34	Lig	Shared	100	100	23	16	0
35	NT	cxcr_on	16.6667	87.5	3	6	0
36	1x32	cxcr_on	0	0	3	5	0
37	1x47	cxcr_on	0	0	2	4	6
38	1x53	cxcr_on	0	0	1	4	9
39	1x59	cxcr_on	0	0	2	5	5
40	2x38	cxcr_on	0	0	3	4	6
41	2x46	cxcr_on	0	37.5	2	4	9
42	2x57	cxcr_on	0	0	3	4	8
43	E1x52	cxcr_on	50	50	3	6	7
44	3x35	cxcr_on	66.6667	25	3	4	8
45	3x56	cxcr_on	0	25	2	6	6
46	I2x52	cxcr_on	0	0	1	5	4
47	4x42	cxcr_on	50	0	3	5	8
48	4x56	cxcr_on	0	0	3	5	5
49	4x61	cxcr_on	0	37.5	2	4	4
50	4x65	cxcr_on	0	25	2	4	5
51	6x30	cxcr_on	0	0	2	4	0
52	6x58	cxcr_on	0	0	3	4	5
53	7x53	cxcr_on	50	100	3	4	9

Orange: nodes, hubs and links specific of cxcr_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of cxcr_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	cxcr_off Recurrence	cxcr_on Recurrence	cxcr_off Hub1?	cxcr_on Hub1?	cxcr_off Hub2?	cxcr_on Hub2?	ConSurf1	ConSurf2
1	7x32	7x33	cxcr_off	11.4158	0	No	No	No	No	2	5
2	7x33	7x37	cxcr_off	12.9468	1.15389	No	No	No	No	5	7
3	6x51	7x37	cxcr_off	19.0375	5.59599	Yes	Yes	No	No	6	7
4	6x51	7x38	cxcr_off	15.1529	2.73389	Yes	Yes	Yes	No	6	5
5	3x32	6x48	cxcr_off	18.0927	0	Yes	Yes	Yes	Yes	5	9
6	2x50	3x35	cxcr_off	50.4221	0	No	No	No	Yes	9	8
7	2x53	7x42	cxcr_off	45.638	2.53026	Yes	No	Yes	Yes	6	6
8	2x53	7x46	cxcr_off	50.6315	0	Yes	No	No	No	6	8
9	2x50	7x46	cxcr_off	50.3467	1.3726	No	No	No	No	9	8
10	7x49	7x50	cxcr_off	90.4921	0	No	No	No	No	9	9
11	2x43	7x49	cxcr_off	79.6459	0	No	No	No	No	8	9
12	2x43	7x53	cxcr_off	79.0613	0	No	No	No	Yes	8	9
13	7x53	8x50	cxcr_off	74.1248	0	No	Yes	Yes	Yes	9	8
14	8x50	8x53	cxcr_off	71.9153	0	Yes	Yes	No	No	8	5
15	1x60	2x40	cxcr_off	64.0792	0	Yes	Yes	Yes	Yes	5	8
16	2x37	2x40	cxcr_off	52.841	1.3726	No	No	Yes	Yes	7	8
17	2x37	2x39	cxcr_off	49.2295	0	No	No	No	No	7	8
18	2x39	3x46	cxcr_off	21.9438	0	No	No	No	No	8	9
19	2x39	3x50	cxcr_off	26.5336	0	No	No	Yes	No	8	9
20	3x50	3x53	cxcr_off	21.8634	0	Yes	No	No	No	9	8
21	3x53	I2x57	cxcr_off	20.8382	1.19914	No	No	Yes	Yes	8	6
22	2x42	4x45	cxcr_off	13.1679	1.22177	Yes	Yes	No	No	7	5
23	2x45	4x45	cxcr_off	12.4058	0	No	No	No	No	9	5
24	2x45	4x50	cxcr_off	10.1427	2.30401	No	No	Yes	No	9	9
25	2x46	3x42	cxcr_off	12.5649	4.11403	No	Yes	No	No	9	8
26	3x42	4x49	cxcr_off	11.4392	2.74897	No	No	No	No	8	7
27	3x41	4x49	cxcr_off	10.3102	1.37637	No	No	No	No	6	7
28	3x52	I2x57	cxcr_off	18.9001	0	Yes	No	Yes	Yes	5	6
29	3x51	3x52	cxcr_off	11.4577	0	Yes	Yes	Yes	No	8	5
30	7x42	Lig	cxcr_off	26.1684	0	Yes	Yes	Yes	Yes	6	0
31	2x53	3x32	Shared	55.7841	15.0798	Yes	No	Yes	Yes	6	5
32	2x53	3x35	Shared	50.7069	16.5693	Yes	No	No	Yes	6	8
33	1x50	2x50	Shared	100	54.8022	Yes	No	No	No	9	9
34	1x50	7x50	Shared	94.5124	51.6686	Yes	No	No	No	9	9
35	1x60	8x53	Shared	70.6489	13.0246	Yes	Yes	No	No	5	5
36	2x42	3x46	Shared	20.6573	26.4527	Yes	Yes	No	No	7	9
37	2x46	7x49	Shared	13.6872	19.5784	No	Yes	No	No	9	9
38	E2	Lig	Shared	15.9017	90.7199	Yes	Yes	Yes	Yes	3	0
39	3x32	Lig	Shared	28.8217	38.2669	Yes	Yes	Yes	Yes	5	0
40	1x35	1x39	cxcr_on	3.48923	13.281	Yes	No	Yes	Yes	5	8
41	1x39	7x42	cxcr_on	4.7623	16.5994	Yes	Yes	Yes	Yes	8	6
42	3x32	7x42	cxcr_on	1.02348	22.8063	Yes	Yes	Yes	Yes	5	6
43	Lig	NT	cxcr_on	4.34018	18.6432	Yes	Yes	No	Yes	0	0
44	7x38	7x42	cxcr_on	6.90308	25.3403	Yes	No	Yes	Yes	5	6
45	7x38	Lig	cxcr_on	2.69691	23.3154	Yes	No	Yes	Yes	5	0
46	1x32	NT	cxcr_on	0	14.5594	No	Yes	No	Yes	0	0
47	2x57	7x42	cxcr_on	8.49107	30.3443	No	Yes	Yes	Yes	8	6
48	1x42	2x57	cxcr_on	0	17.61	No	No	No	Yes	7	8
49	1x43	2x57	cxcr_on	2.67178	11.8066	No	No	No	Yes	7	8
50	2x50	7x49	cxcr_on	0	56.8536	No	No	No	No	9	9
51	7x45	7x49	cxcr_on	0	49.5381	No	No	No	No	9	9
52	6x48	7x45	cxcr_on	2.55787	51.3028	Yes	Yes	No	No	9	9
53	3x36	6x48	cxcr_on	0.882777	98.141	Yes	No	Yes	Yes	7	9
54	3x36	3x37	cxcr_on	5.07387	98.3106	Yes	No	Yes	Yes	7	6
55	3x33	3x37	cxcr_on	0	99.6795	No	No	Yes	Yes	4	6
56	3x33	4x61	cxcr_on	0.482428	100	No	No	No	Yes	4	4
57	4x61	E2x52	cxcr_on	1.14074	93.4085	No	Yes	Yes	Yes	4	3
58	E2	E2x52	cxcr_on	0.157459	92.6694	Yes	Yes	Yes	Yes	3	3
59	1x53	7x50	cxcr_on	0	48.4671	No	Yes	No	No	9	9
60	1x56	8x50	cxcr_on	0	17.0444	No	No	Yes	Yes	7	8
61	1x53	8x50	cxcr_on	0	45.0545	No	Yes	Yes	Yes	9	8
62	1x57	8x50	cxcr_on	0	24.4617	No	No	Yes	Yes	7	8
63	2x40	8x53	cxcr_on	0	14.3218	Yes	Yes	No	No	8	5
64	1x57	2x40	cxcr_on	5.77239	19.4615	No	No	Yes	Yes	7	8
65	2x42	3x49	cxcr_on	3.9214	12.2214	Yes	Yes	Yes	Yes	7	8
66	3x46	3x50	cxcr_on	0	21.7995	No	No	Yes	No	9	9
67	3x50	5x58	cxcr_on	0	27.9422	Yes	No	Yes	Yes	9	8
68	5x54	5x58	cxcr_on	0	42.0566	No	No	Yes	Yes	8	8
69	5x54	6x44	cxcr_on	0	60.4359	No	No	Yes	No	8	9
70	6x44	6x48	cxcr_on	9.34035	62.4948	Yes	No	Yes	Yes	9	9
71	2x42	4x42	cxcr_on	0	11.0713	Yes	Yes	No	Yes	7	8
72	2x46	3x43	cxcr_on	0	16.9765	No	Yes	No	No	9	8
73	E1x50	E1x52	cxcr_on	2.72538	12.4251	Yes	Yes	No	Yes	9	7
74	E1x50	E2	cxcr_on	1.3183	10.2304	Yes	Yes	Yes	Yes	9	3
75	3x43	7x53	cxcr_on	0	16.4373	No	No	No	Yes	8	9
76	3x47	5x54	cxcr_on	0.666689	17.8174	No	No	No	No	9	8
77	3x47	5x57	cxcr_on	0	21.2376	No	No	No	No	9	7
78	3x51	5x57	cxcr_on	1.19937	18.9826	Yes	Yes	No	No	8	7
79	3x51	3x56	cxcr_on	1.15582	10.7847	Yes	Yes	No	Yes	8	6
80	5x58	5x61	cxcr_on	0	14.318	Yes	Yes	Yes	No	8	8
81	6x51	Lig	cxcr_on	0	13.8127	Yes	Yes	Yes	Yes	6	0
82	5x58	6x37	cxcr_on	0	11.1882	Yes	Yes	No	No	8	7
83	5x61	5x65	cxcr_on	0.800697	11.1882	Yes	No	No	No	8	0
84	8x52	8x55	cxcr_on	0	10.5396	No	No	No	No	5	2
85	8x54	8x55	cxcr_on	0.787296	13.1641	No	No	No	No	6	2
86	1x56	8x54	cxcr_on	3.93648	15.7585	No	No	No	No	7	6
87	2x38	4x41	cxcr_on	0	10.9846	No	Yes	No	No	6	4

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
1x35	1x39	Shared	8.01167	5.995	1	0	1	1
1x35	Lig	cxcr_off	2.94	0	1	0	1	0
1x39	2x60	cxcr_off	4.34167	0	1	1	1	1
1x39	Lig	cxcr_off	7.89	0	1	1	1	0
2x53	3x32	Shared	3.19	6.165	1	1	2	1
2x53	7x42	Shared	10	3.8675	1	1	2	1
2x56	2x60	cxcr_off	3.03333	0	0	0	2	1
2x57	7x42	Shared	3.36167	3.86875	0	1	2	1
2x60	E1x50	cxcr_off	4.215	0	1	1	1	2
2x60	3x28	Shared	3.17167	2.81	1	1	1	2
2x60	7x42	cxcr_off	5.25	0	1	1	1	1
2x60	Lig	Shared	17.1133	13.165	1	1	1	0
2x63	E1x50	Shared	7.81667	6.7475	1	1	1	2
E1x49	E2	Shared	12.2833	3.9175	1	1	2	1
E1x50	E2	Shared	5.03667	4.1525	1	1	2	1
3x22	E2	Shared	7.195	6.67625	1	0	2	1
3x29	4x65	Shared	4.51333	8.15	1	1	1	2
3x29	Lig	cxcr_off	4.30333	0	1	1	1	0
3x32	6x48	cxcr_off	3.14667	0	1	1	1	2
3x32	7x38	cxcr_off	3.75167	0	1	1	1	1
3x32	7x42	Shared	7.04833	3.74	1	1	1	1
3x32	Lig	Shared	5.50333	7.57875	1	1	1	0
3x36	6x48	Shared	6.27	7.05125	1	0	2	2
3x36	6x52	cxcr_off	4.72	0	1	0	2	2
4x61	E2x52	Shared	8.235	9.72	0	1	2	1
4x64	E2	Shared	20.5633	8.24625	1	1	2	1
4x65	E2x52	Shared	8.31	8.30375	0	1	2	1
E2	E2	Shared	44.3	40.975	1	1	1	1
E2	E2x51	Shared	12.275	8.3925	1	1	1	1
E2	E2x52	Shared	11.5	6.38625	1	1	1	1
5x36	E2x52	cxcr_off	3.6	0	1	1	1	1
5x35	E2	Shared	14.0017	11.8237	1	1	2	1
5x36	E2	cxcr_off	6.91333	0	1	1	1	1
5x40	6x58	Shared	4.82333	6.515	1	0	1	1
5x40	6x59	Shared	4.625	5.27625	1	0	1	2
5x40	6x62	cxcr_off	4.765	0	1	0	1	1
6x48	6x51	cxcr_off	6.27167	0	1	0	2	1
6x51	6x55	Shared	7.78833	7.535	0	1	1	2
6x51	7x37	Shared	6.45167	4.995	0	1	1	2
6x51	7x38	Shared	7.52333	6.24625	0	1	1	1
6x54	7x34	Shared	3.745	3.06125	0	0	2	1
6x58	6x62	Shared	3.55167	4.10625	1	1	1	1
6x62	E3	cxcr_off	3.575	0	1	1	1	2
7x27	E3	Shared	3.49	3.34375	1	1	1	2
7x27	7x31	cxcr_off	4.48167	0	1	1	1	1
7x34	Lig	Shared	3.65167	4.27875	1	1	1	0
7x35	Lig	Shared	9.52833	3.545	0	0	1	0
7x38	Lig	Shared	8.94333	9.2775	1	1	1	0
7x42	Lig	cxcr_off	14.115	0	1	1	1	0
Lig	NT	Shared	13.9217	41.1275	1	1	0	1
1x24	7x28	cxcr_off	3.21333	0	1	0	1	2
1x24	Lig	cxcr_off	2.95333	0	1	0	1	0
1x39	7x42	Shared	2.92333	5.9175	1	1	1	1
2x60	3x32	Shared	4.34167	9.21375	1	1	1	1
2x63	Lig	cxcr_off	6.22833	0	1	1	1	0
3x32	3x36	cxcr_off	4.69	0	1	1	1	2
4x64	5x35	cxcr_off	3.50833	0	1	1	2	2
E2	Lig	Shared	15.8583	31.7425	1	1	1	0
E2x51	Lig	Shared	4.46167	11.545	1	1	1	0
5x34	E2	cxcr_off	2.975	0	0	0	2	1
6x58	Lig	Shared	4.87	4.45375	1	1	1	0
6x62	Lig	Shared	3.435	5.57375	1	1	1	0
6x64	E3	cxcr_off	3.375	0	0	0	1	2
7x27	Lig	Shared	4.56333	13.3762	1	1	1	0
7x31	Lig	cxcr_off	2.97333	0	1	0	1	0
7x38	7x42	Shared	3.30333	7.73875	1	1	1	1
E2x52	Lig	cxcr_off	5.585	0	1	1	1	0
5x40	Lig	cxcr_off	3.75	0	1	0	1	0
5x39	E2	Shared	2.75167	3.70375	1	1	2	1
1x39	2x61	Shared	2.66833	3.6675	1	1	1	2
7x24	NT	Shared	2.42667	7.0525	0	0	2	1
1x31	1x35	Shared	2.28833	4.00625	0	0	2	1
1x39	7x39	cxcr_off	2.22333	0	1	1	1	2
1x27	7x28	cxcr_off	2.04333	0	0	0	2	2
1x35	2x64	Shared	1.84167	3.08	1	0	1	2
1x25	NT	cxcr_off	1.555	0	0	0	2	1
5x32	E2	Shared	1.445	3.82375	0	0	2	1
5x33	Lig	cxcr_off	1.305	0	0	0	1	0
5x37	6x62	Shared	1.22167	5.46	0	0	2	1
NT	NT	cxcr_on	0	24.8462	1	1	1	1
1x27	7x31	cxcr_on	0	4.475	0	0	2	1
1x39	2x57	cxcr_on	0	4.68875	1	1	1	2
2x63	E2	cxcr_on	0	4.4475	1	1	1	1
3x29	4x61	cxcr_on	0	3.86625	1	1	1	2
4x61	4x65	cxcr_on	0	4.4625	0	1	2	2
5x39	E2x52	cxcr_on	0	3.88125	1	1	2	1
5x36	Lig	cxcr_on	0	6.05875	1	1	1	0
5x37	6x59	cxcr_on	0	4.0375	0	0	2	2
5x40	6x55	cxcr_on	0	7.7	1	0	1	2
6x51	6x52	cxcr_on	0	5.63125	0	1	1	2
6x51	Lig	cxcr_on	0	4.485	0	1	1	0
E3	E3	cxcr_on	0	3.83375	0	1	2	2
7x28	NT	cxcr_on	0	6.1225	0	1	2	1
5x36	E2x51	cxcr_on	0	6.945	1	1	1	1
5x31	5x34	cxcr_on	0	4.1225	0	1	2	2
1x24	7x31	cxcr_on	0	3.95	1	0	1	1
6x64	Lig	cxcr_on	0	2.9125	0	0	1	0
6x58	7x30	cxcr_on	0	2.6775	1	1	1	2
1x32	NT	cxcr_on	0	2.3625	0	1	2	1
5x33	5x36	cxcr_on	0	2.33625	0	0	1	1
5x31	E2	cxcr_on	0	1.3625	0	1	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	cxcr_off	cxcr3_off cxcr4_off
	cxcr_on	cxcr3_on cxcr4_on cxcr1_on cxcr2_on

Network Difference
Value	cxcr_off	cxcr_on
I_min	2.90833	3.56125
Number of Linked Nodes	263	280
Number of Specific Nodes	1 (0.38%)	18 (6.43%)
Number of Shared Nodes	262 (99.62%)	262 (93.57%)
Number of Links	302	309
Number of Specific Links	132 (43.71%)	139 (44.98%)
Number of Shared Links	170 (56.29%)	170 (55.02%)
Number of Hubs	34	38
Number of Specific Hubs	15 (44.12%)	19 (50.00%)
Number of Shared Hubs	19 (55.88%)	19 (50.00%)
Average % Shared Neighbours (Jaccard)	41.55
Average % Shared Neighbours (Otsuka)	51.02
Average % Shared Neighbours (Overlap Coefficient)	60.99
Average % Shared Cliques (k3-6)	54.17
Graphlets Similarity	0.611443

Paths Difference
Value	cxcr_off	cxcr_on
Number Of Nodes in MetaPath	39	58
Specific Nodes in MetaPath	16 (41.03%)	35 (60.34%)
Shared Nodes in MetaPath	262 (99.62%)	262 (99.62%)
Number Of Links MetaPath	39	57
Specific Links in MetaPath	30 (76.92%)	48 (84.21%)
Shared Links in MetaPath	170 (56.29%)	170 (56.29%)
Number of Shortest Paths	80138	51343
Length Of Smallest Path	3	3
Average Path Length	16.7218	14.2587
Length of Longest Path	34	33
Minimum Path Strength	0.728889	0.69375
Average Path Strength	5.57351	6.70294
Maximum Path Strength	18.2108	28.2312
Minimum Path Correlation	0.7	0.70875
Average Path Correlation	0.90409	0.939893
Maximum Path Correlation	0.986667	0.98875
Minimum % Of Corr. Nodes	3.57143	3.22581
Average % Of Corr. Nodes	32.1806	51.1666
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	41.023	44.9839
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

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