psnGPCR

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Orange: nodes, hubs and links specific of d2_on network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of d2_off network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	d2_on Int. Strength	d2_off Int. Strength	d2_on Hub1?	d2_off Hub1?	d2_on Hub2?	d2_off Hub2?	ConSurf1	ConSurf2
1	1x48	1x52	d2_on	100	0	No	No	Yes	No	5	8
2	1x53	7x54	d2_on	100	0	No	No	No	No	9	8
3	2x37	I2x53	d2_on	100	0	No	No	Yes	No	8	8
4	2x38	I2x53	d2_on	100	0	No	No	Yes	No	7	8
5	2x39	I2x53	d2_on	100	0	No	No	Yes	No	8	8
6	2x46	2x50	d2_on	100	0	Yes	No	Yes	No	9	9
7	2x46	3x43	d2_on	100	0	Yes	No	No	No	9	8
8	2x46	7x49	d2_on	100	0	Yes	No	No	No	9	9
9	2x50	7x49	d2_on	100	0	Yes	No	No	No	9	9
10	2x61	7x39	d2_on	100	0	No	No	Yes	Yes	8	8
11	3x29	4x61	d2_on	100	0	No	No	Yes	No	6	8
12	3x29	E2x52	d2_on	100	0	No	No	No	No	6	7
13	3x33	4x57	d2_on	100	0	No	No	No	No	8	9
14	3x34	4x53	d2_on	100	0	Yes	No	No	No	7	8
15	3x36	6x48	d2_on	100	0	No	No	Yes	Yes	8	9
16	3x40	6x48	d2_on	100	0	No	No	Yes	Yes	9	9
17	3x43	7x53	d2_on	100	0	No	No	Yes	Yes	8	9
18	3x44	5x50	d2_on	100	0	No	No	No	No	7	9
19	3x46	3x50	d2_on	100	0	No	No	No	Yes	9	9
20	3x49	I2x53	d2_on	100	0	Yes	Yes	Yes	No	8	8
21	3x50	5x58	d2_on	100	0	No	Yes	Yes	Yes	9	9
22	3x50	7x53	d2_on	100	0	No	Yes	Yes	Yes	9	9
23	3x53	I2x53	d2_on	100	0	No	No	Yes	No	8	8
24	3x56	I2x52	d2_on	100	0	No	No	No	No	6	6
25	4x56	5x461	d2_on	100	0	No	No	No	No	8	8
26	4x59	4x63	d2_on	100	0	No	No	No	No	6	6
27	4x60	5x39	d2_on	100	0	No	No	Yes	Yes	8	8
28	E2.A177	E2.N175	d2_on	100	0	No	No	Yes	No	4	7
29	E2.N175	E2x52	d2_on	100	0	Yes	No	No	No	7	7
30	E2x51	Lig	d2_on	100	0	No	Yes	Yes	Yes	5	0
31	5x36	5x39	d2_on	100	0	No	Yes	Yes	Yes	7	8
32	5x43	Lig	d2_on	100	0	No	No	Yes	Yes	9	0
33	5x44	5x48	d2_on	100	0	No	No	No	No	8	7
34	5x47	5x51	d2_on	100	0	Yes	Yes	Yes	No	9	7
35	5x47	6x44	d2_on	100	0	Yes	Yes	Yes	Yes	9	9
36	5x47	6x48	d2_on	100	0	Yes	Yes	Yes	Yes	9	9
37	5x51	6x44	d2_on	100	0	Yes	No	Yes	Yes	7	9
38	5x55	6x41	d2_on	100	0	No	No	No	No	6	8
39	5x56	5x60	d2_on	100	0	No	No	No	No	5	7
40	5x58	6x40	d2_on	100	0	Yes	Yes	No	No	9	9
41	5x61	6x37	d2_on	100	0	Yes	No	No	No	9	8
42	5x62	6x34	d2_on	100	0	No	No	No	No	7	8
43	5x68	6x30	d2_on	100	0	No	No	No	No	8	9
44	5x69	6x30	d2_on	100	0	No	No	No	No	6	9
45	6x39	7x52	d2_on	100	0	No	No	No	No	8	8
46	6x40	7x53	d2_on	100	0	No	No	Yes	Yes	9	9
47	6x43	7x45	d2_on	100	0	No	No	Yes	Yes	7	9
48	6x43	7x48	d2_on	100	0	No	No	No	No	7	7
49	6x48	7x45	d2_on	100	0	Yes	Yes	Yes	Yes	9	9
50	6x55	6x59	d2_on	100	0	No	No	No	No	8	6
51	6x56	6x60	d2_on	100	0	No	No	No	No	7	6
52	7x34	E3.I403	d2_on	100	0	No	Yes	No	Yes	5	6
53	7x33	7x37	d2_on	100	0	No	No	No	No	6	5
54	7x35	7x39	d2_on	100	0	No	No	Yes	Yes	6	8
55	7x54	8x50	d2_on	100	0	No	No	Yes	Yes	8	9
56	7x55	8x54	d2_on	100	0	No	No	No	Yes	7	9
57	5x36	E2.N175	d2_on	100	0	No	Yes	Yes	No	7	7
58	1x52	8x57	d2_on	50	0	Yes	No	No	No	8	8
59	5x58	6x37	d2_on	50	0	Yes	Yes	No	No	9	8
60	6x35	6x39	d2_on	50	0	No	No	No	No	8	8
61	1x35	2x64	d2_on	50	0	No	Yes	No	No	5	7
62	5x65	6x30	d2_on	50	0	No	No	No	No	8	9
63	2x60	3x28	d2_on	0	0	No	No	No	No	8	7
64	2x53	7x46	d2_on	50	0	No	No	No	No	8	9
65	2x41	4x42	d2_on	50	0	No	No	No	No	7	7
66	E1x51	E1x52	d2_on	50	0	No	No	Yes	Yes	4	7
67	5x69	6x27	d2_on	50	0	No	No	No	No	6	5
68	6x28	6x35	d2_on	50	0	No	No	No	No	6	8
69	3x51	5x57	d2_on	50	0	Yes	Yes	No	No	8	7
70	3x26	4x64	d2_on	50	0	No	Yes	No	No	6	7
71	2x57	2x58	d2_on	0	0	No	No	No	No	9	9
72	1x32	1x35	d2_on	0	0	No	No	No	Yes	6	5
73	4x60	E2.L174	d2_on	0	0	No	No	No	No	8	7
74	5x62	6x37	d2_on	50	0	No	No	No	No	7	8
75	3x22	E2.Q179	d2_on	0	0	No	No	No	No	3	1
76	5x41	6x59	d2_on	0	0	No	No	No	No	7	6
77	1x57	I1x50	d2_on	0	0	No	No	Yes	No	8	9
78	1x33	1x37	d2_on	0	0	No	No	No	No	7	6
79	3x27	3x31	d2_on	0	0	No	No	No	No	6	6
80	1x52	8x58	d2_on	50	0	Yes	No	No	No	8	8
81	6x28	6x32	d2_on	0	0	No	No	No	No	6	9
82	5x51	5x52	d2_on	0	0	Yes	No	No	No	7	4
83	3x22	3x23	d2_on	50	0	No	No	No	No	3	4
84	1x54	2x47	d2_on	0	0	No	No	No	No	7	9
85	1x56	8x53	d2_on	0	0	No	No	No	No	9	9
86	I2x50	I2x51	d2_on	50	0	No	No	No	No	9	6
87	3x44	3x48	d2_on	0	0	No	No	No	No	7	7
88	3x55	3x56	d2_on	0	0	No	No	No	No	8	6
89	6x57	6x61	d2_on	0	0	No	No	No	No	7	6
90	5x65	6x33	d2_on	0	0	No	No	No	No	8	9
91	3x54	5x61	d2_on	0	0	No	No	Yes	No	8	9
92	8x47	8x48	d2_on	0	0	No	No	No	No	9	5
93	5x64	5x67	d2_on	0	0	No	No	No	No	7	6
94	5x69	5x73	d2_on	0	0	No	No	No	No	6	5
95	E2.A177	E2.A185	d2_on	0	0	No	No	No	No	4	7
96	4x37	4x38	d2_on	0	0	No	No	No	No	8	6
97	2x61	2x65	d2_on	0	0	No	No	No	No	8	6
98	1x33	1x36	d2_on	0	0	No	No	No	No	7	7
99	1x41	1x45	d2_on	0	0	No	No	No	No	6	5
100	3x21	E2.Q179	d2_on	0	0	No	No	No	No	8	1
101	E2.D178	E2.N180	d2_on	0	0	No	No	No	No	3	3
102	5x38	5x42	d2_on	0	0	No	No	No	Yes	5	7
103	4x40	4x44	d2_on	0	0	No	No	No	No	6	3
104	5x41	5x42	d2_on	0	0	No	No	No	Yes	7	7
105	5x68	5x71	d2_on	0	0	No	No	No	No	8	6
106	1x39	2x61	Shared	100	100	No	No	No	No	7	8
107	1x39	7x39	Shared	100	100	No	No	Yes	Yes	7	8
108	1x42	1x46	Shared	100	100	No	No	Yes	Yes	7	8
109	1x43	2x57	Shared	100	100	No	No	No	No	8	9
110	1x48	1x49	Shared	100	100	No	No	No	No	5	9
111	1x49	7x50	Shared	100	100	No	No	No	No	9	9
112	1x50	2x47	Shared	100	100	Yes	Yes	No	No	9	9
113	1x50	2x50	Shared	100	100	Yes	Yes	Yes	No	9	9
114	1x50	2x51	Shared	100	100	Yes	Yes	No	No	9	8
115	1x50	7x50	Shared	100	100	Yes	Yes	No	No	9	9
116	1x57	2x44	Shared	100	100	No	No	No	No	8	7
117	1x59	8x57	Shared	100	100	No	No	No	No	7	8
118	1x60	I1x50	Shared	100	100	No	Yes	Yes	No	8	9
119	1x60	8x56	Shared	100	100	No	Yes	No	No	8	7
120	8x49	I1x49	Shared	100	33.3333	No	Yes	No	No	7	7
121	8x50	I1x50	Shared	100	100	Yes	Yes	Yes	No	9	9
122	2x41	I1x51	Shared	100	100	No	No	No	No	7	8
123	2x37	2x40	Shared	100	100	No	No	No	No	8	9
124	2x38	3x49	Shared	100	100	No	No	Yes	Yes	7	8
125	2x38	4x38	Shared	100	66.6667	No	No	No	No	7	6
126	2x39	3x49	Shared	100	100	No	No	Yes	Yes	8	8
127	2x40	8x50	Shared	100	100	No	No	Yes	Yes	9	9
128	2x42	3x49	Shared	100	100	No	No	Yes	Yes	8	8
129	2x43	7x53	Shared	100	100	No	No	Yes	Yes	8	9
130	2x45	3x42	Shared	100	100	No	No	No	No	9	8
131	2x45	4x46	Shared	100	100	No	No	No	No	9	9
132	2x45	4x50	Shared	100	100	No	No	No	No	9	9
133	2x46	3x42	Shared	100	100	Yes	No	No	No	9	8
134	2x50	3x39	Shared	100	100	Yes	No	No	No	9	9
135	2x50	7x46	Shared	100	100	Yes	No	No	No	9	9
136	2x52	2x551	Shared	100	100	No	No	No	No	7	5
137	2x52	3x35	Shared	100	100	No	No	No	No	7	7
138	2x56	3x32	Shared	100	100	No	No	No	No	8	8
139	2x57	7x42	Shared	100	100	No	No	Yes	Yes	9	8
140	2x59	3x24	Shared	100	100	No	No	No	Yes	6	6
141	2x59	3x28	Shared	100	100	No	No	No	No	6	7
142	2x60	7x39	Shared	100	100	No	No	Yes	Yes	8	8
143	2x60	7x42	Shared	100	100	No	No	Yes	Yes	8	8
144	2x62	2x66	Shared	100	100	No	No	No	Yes	6	5
145	2x64	7x35	Shared	100	100	No	No	No	No	7	6
146	2x64	7x39	Shared	100	100	No	No	Yes	Yes	7	8
147	E1x49	E1x51	Shared	100	100	No	No	No	No	4	4
148	E1x50	E1x52	Shared	100	100	Yes	Yes	Yes	Yes	9	7
149	3x24	E1x50	Shared	100	100	No	Yes	Yes	Yes	6	9
150	3x25	E1x50	Shared	100	100	No	No	Yes	Yes	9	9
151	3x28	E1x50	Shared	100	100	No	No	Yes	Yes	7	9
152	E1x50	E2x50	Shared	100	100	Yes	Yes	No	No	9	9
153	3x24	E1x52	Shared	100	100	No	Yes	Yes	Yes	6	7
154	3x25	E2x50	Shared	100	100	No	No	No	No	9	9
155	3x30	4x62	Shared	100	100	No	No	No	No	8	7
156	3x32	7x42	Shared	100	100	No	No	Yes	Yes	8	8
157	3x32	Lig	Shared	100	100	No	No	Yes	Yes	8	0
158	3x33	4x61	Shared	100	100	No	No	Yes	No	8	8
159	3x33	Lig	Shared	100	100	No	No	Yes	Yes	8	0
160	3x34	4x54	Shared	100	33.3333	Yes	No	No	No	7	6
161	3x34	4x57	Shared	100	100	Yes	No	No	No	7	9
162	3x36	Lig	Shared	100	100	No	No	Yes	Yes	8	0
163	3x37	5x461	Shared	100	100	No	No	No	No	8	8
164	3x38	4x50	Shared	100	100	No	No	No	No	8	9
165	3x40	6x44	Shared	100	100	No	No	Yes	Yes	9	9
166	3x41	4x49	Shared	100	100	No	No	No	No	8	9
167	3x41	4x52	Shared	100	100	No	No	No	No	8	7
168	3x42	4x49	Shared	100	100	No	No	No	No	8	9
169	3x43	6x44	Shared	100	100	No	No	Yes	Yes	8	9
170	3x47	5x54	Shared	100	100	No	No	No	No	9	9
171	3x47	5x58	Shared	100	100	No	No	Yes	Yes	9	9
172	3x49	4x41	Shared	100	100	Yes	Yes	No	No	8	8
173	3x51	3x55	Shared	100	100	Yes	Yes	No	No	8	8
174	3x51	5x60	Shared	100	100	Yes	Yes	No	No	8	7
175	3x51	5x61	Shared	100	100	Yes	Yes	Yes	No	8	9
176	3x52	4x41	Shared	100	100	No	No	No	No	6	8
177	3x54	5x64	Shared	100	100	No	No	No	No	8	7
178	4x34	4x37	Shared	100	100	No	No	No	No	7	8
179	4x56	5x46	Shared	100	100	No	No	No	No	8	6
180	4x61	5x39	Shared	100	100	Yes	No	Yes	Yes	8	8
181	E2x52	Lig	Shared	100	100	No	No	Yes	Yes	7	0
182	5x39	5x43	Shared	100	100	Yes	Yes	No	No	8	9
183	5x40	6x55	Shared	100	100	No	No	No	No	7	8
184	5x44	6x52	Shared	100	100	No	No	Yes	Yes	8	8
185	5x461	Lig	Shared	100	100	No	No	Yes	Yes	8	0
186	5x47	5x48	Shared	100	100	Yes	Yes	No	No	9	7
187	5x47	6x52	Shared	100	100	Yes	Yes	Yes	Yes	9	8
188	5x48	6x56	Shared	100	100	No	No	No	No	7	7
189	5x51	6x45	Shared	100	100	Yes	No	No	No	7	7
190	5x58	6x41	Shared	100	100	Yes	Yes	No	No	9	8
191	5x62	5x66	Shared	100	0	No	No	No	No	7	6
192	5x66	5x70	Shared	100	33.3333	No	No	No	No	6	7
193	6x36	7x56	Shared	100	100	No	No	No	Yes	9	8
194	6x44	6x48	Shared	100	100	Yes	Yes	Yes	Yes	9	9
195	6x47	7x45	Shared	100	100	No	No	Yes	Yes	9	9
196	6x48	6x52	Shared	100	100	Yes	Yes	Yes	Yes	9	8
197	6x48	7x41	Shared	100	100	Yes	Yes	No	No	9	8
198	6x49	6x53	Shared	100	100	No	No	No	No	7	7
199	6x50	7x37	Shared	100	100	No	No	No	No	9	5
200	6x51	7x38	Shared	100	100	Yes	Yes	No	No	8	8
201	6x51	Lig	Shared	100	100	Yes	Yes	Yes	Yes	8	0
202	6x52	Lig	Shared	100	100	Yes	Yes	Yes	Yes	8	0
203	6x54	7x37	Shared	100	100	No	No	No	No	5	5
204	6x58	E3.I403	Shared	100	100	No	No	No	Yes	5	6
205	6x58	7x34	Shared	100	100	No	No	No	Yes	5	5
206	6x61	E3.C401	Shared	100	100	No	No	No	No	6	7
207	7x30	E3.I403	Shared	100	100	Yes	Yes	No	Yes	6	6
208	7x34	Lig	Shared	100	100	No	Yes	Yes	Yes	5	0
209	7x38	7x42	Shared	100	100	No	No	Yes	Yes	8	8
210	7x38	Lig	Shared	100	100	No	No	Yes	Yes	8	0
211	7x42	Lig	Shared	100	100	Yes	Yes	Yes	Yes	8	0
212	7x45	7x49	Shared	100	100	Yes	Yes	No	No	9	9
213	7x51	7x55	Shared	100	0	No	No	No	No	7	7
214	7x54	8x54	Shared	100	100	No	No	No	Yes	8	9
215	8x47	8x50	Shared	100	100	No	No	Yes	Yes	9	9
216	6x51	6x52	Shared	100	100	Yes	Yes	Yes	Yes	8	8
217	6x51	6x55	Shared	100	100	Yes	Yes	No	No	8	8
218	7x30	7x33	Shared	100	100	Yes	Yes	No	No	6	6
219	1x52	8x54	Shared	50	100	Yes	No	No	Yes	8	9
220	5x47	6x49	Shared	50	0	Yes	Yes	No	No	9	7
221	3x34	3x35	Shared	50	0	Yes	No	No	No	7	7
222	5x55	5x59	Shared	50	100	No	No	No	No	6	4
223	5x49	5x50	Shared	50	100	No	No	No	No	8	9
224	2x551	3x31	Shared	50	0	No	No	No	No	5	6
225	3x44	5x53	Shared	50	66.6667	No	No	No	No	7	8
226	5x36	E2.N176	Shared	50	33.3333	No	Yes	No	No	7	7
227	I1x48	I1x51	Shared	50	100	No	No	No	No	8	8
228	3x40	5x50	Shared	50	100	No	No	No	No	9	9
229	1x46	2x54	Shared	50	100	Yes	Yes	No	No	8	8
230	2x49	4x50	Shared	0	0	No	No	No	No	8	9
231	2x62	E1x52	Shared	50	100	No	No	Yes	Yes	6	7
232	1x46	7x46	Shared	50	100	Yes	Yes	No	No	8	9
233	6x43	7x52	Shared	50	100	No	No	No	No	7	8
234	4x42	4x46	Shared	0	33.3333	No	No	No	No	7	9
235	4x44	4x48	Shared	0	66.6667	No	No	No	No	3	4
236	1x42	7x43	Shared	0	0	No	No	No	No	7	6
237	1x47	2x51	Shared	50	100	No	No	No	No	7	8
238	2x55	2x551	Shared	0	100	No	No	No	No	6	5
239	3x30	4x61	Shared	50	100	No	No	Yes	No	8	8
240	4x54	4x59	Shared	50	100	No	No	No	No	6	6
241	E2.E181	E2x51	Shared	50	33.3333	No	No	No	Yes	4	5
242	8x49	I1x50	Shared	0	100	No	Yes	Yes	No	7	9
243	1x36	2x65	Shared	0	0	No	No	No	No	7	6
244	1x45	7x47	Shared	50	33.3333	No	No	No	No	5	7
245	5x37	6x59	Shared	50	0	No	No	No	No	4	6
246	6x39	7x56	Shared	0	100	No	No	No	Yes	8	8
247	6x50	7x40	Shared	0	33.3333	No	No	No	No	9	8
248	3x22	3x26	Shared	0	100	No	No	No	Yes	3	6
249	2x42	3x45	Shared	0	100	No	No	No	No	8	7
250	5x41	5x45	Shared	0	66.6667	No	No	No	No	7	6
251	1x51	1x55	Shared	0	33.3333	No	No	No	No	6	5
252	2x63	E1x50	Shared	50	100	No	No	Yes	Yes	7	9
253	1x60	8x53	Shared	0	100	No	Yes	No	No	8	9
254	1x51	2x51	Shared	0	33.3333	No	No	No	No	6	8
255	2x48	2x52	Shared	0	0	No	No	No	No	7	7
256	5x59	5x63	Shared	0	0	No	No	No	No	4	5
257	5x61	5x65	Shared	0	0	Yes	No	No	No	9	8
258	6x27	6x31	Shared	50	33.3333	No	No	No	No	5	7
259	3x26	E2.N175	Shared	50	33.3333	No	Yes	Yes	No	6	7
260	E1x49	E2.N180	Shared	50	33.3333	No	No	No	No	4	3
261	7x30	7x31	Shared	0	0	Yes	Yes	No	No	6	3
262	2x41	4x39	Shared	50	66.6667	No	No	No	Yes	7	6
263	7x30	7x32	Shared	0	33.3333	Yes	Yes	No	No	6	4
264	1x35	1x38	Shared	50	0	No	Yes	No	No	5	5
265	3x56	I2x50	Shared	0	33.3333	No	No	No	No	6	9
266	1x46	7x47	Shared	0	66.6667	Yes	Yes	No	No	8	7
267	4x51	4x55	Shared	0	0	No	No	No	No	5	5
268	3x48	4x45	Shared	0	33.3333	No	No	No	No	7	8
269	2x66	2x67	Shared	0	0	No	Yes	No	No	5	5
270	6x41	6x42	Shared	0	0	No	No	No	No	8	7
271	4x43	4x47	Shared	0	0	No	No	No	No	5	5
272	2x65	2x66	Shared	0	33.3333	No	No	No	Yes	6	5
273	8x48	8x52	Shared	0	33.3333	No	No	No	No	5	6
274	4x36	4x37	Shared	0	0	No	No	No	No	8	8
275	1x53	2x47	d2_off	0	100	No	No	No	No	9	9
276	1x53	7x50	d2_off	0	100	No	No	No	No	9	9
277	1x53	7x53	d2_off	0	100	No	No	Yes	Yes	9	9
278	1x57	8x50	d2_off	0	100	No	No	Yes	Yes	8	9
279	2x38	4x42	d2_off	0	100	No	No	No	No	7	7
280	2x39	3x50	d2_off	0	100	No	No	No	Yes	8	9
281	2x42	3x46	d2_off	0	100	No	No	No	No	8	9
282	2x46	3x39	d2_off	0	100	Yes	No	No	No	9	9
283	2x53	2x57	d2_off	0	100	No	No	No	No	8	9
284	2x53	3x35	d2_off	0	100	No	No	No	No	8	7
285	2x59	E1x52	d2_off	0	100	No	No	Yes	Yes	6	7
286	2x60	Lig	d2_off	0	100	No	No	Yes	Yes	8	0
287	2x63	Lig	d2_off	0	100	No	No	Yes	Yes	7	0
288	3x21	3x23	d2_off	0	100	No	No	No	No	8	4
289	3x21	3x24	d2_off	0	100	No	No	No	Yes	8	6
290	3x29	E2x51	d2_off	0	100	No	No	No	Yes	6	5
291	3x29	5x39	d2_off	0	100	No	No	Yes	Yes	6	8
292	3x38	4x53	d2_off	0	100	No	No	No	No	8	8
293	3x39	6x44	d2_off	0	100	No	No	Yes	Yes	9	9
294	3x41	5x50	d2_off	0	100	No	No	No	No	8	9
295	3x44	5x54	d2_off	0	100	No	No	No	No	7	9
296	3x47	5x57	d2_off	0	100	No	No	No	No	9	7
297	3x50	3x53	d2_off	0	100	No	Yes	No	No	9	8
298	3x50	6x30	d2_off	0	100	No	Yes	No	No	9	9
299	3x50	6x34	d2_off	0	100	No	Yes	No	No	9	8
300	3x50	6x37	d2_off	0	100	No	Yes	No	No	9	8
301	3x53	6x30	d2_off	0	100	No	No	No	No	8	9
302	4x36	4x40	d2_off	0	100	No	No	No	No	8	6
303	4x39	4x42	d2_off	0	100	No	Yes	No	No	6	7
304	4x39	4x43	d2_off	0	100	No	Yes	No	No	6	5
305	4x41	4x45	d2_off	0	100	No	No	No	No	8	8
306	4x52	4x56	d2_off	0	100	No	No	No	No	7	8
307	4x56	5x42	d2_off	0	100	No	No	No	Yes	8	7
308	4x60	5x42	d2_off	0	100	No	No	No	Yes	8	7
309	4x62	4x63	d2_off	0	100	No	No	No	No	7	6
310	E2.L174	E2x51	d2_off	0	100	No	No	No	Yes	7	5
311	5x42	E2.L174	d2_off	0	100	No	Yes	No	No	7	7
312	5x36	E2.D178	d2_off	0	100	No	Yes	No	No	7	3
313	E2.A185	E2.E181	d2_off	0	100	No	No	No	No	7	4
314	5x39	E2x52	d2_off	0	100	Yes	Yes	No	No	8	7
315	5x36	5x37	d2_off	0	100	No	Yes	No	No	7	4
316	5x36	5x38	d2_off	0	100	No	Yes	No	No	7	5
317	5x42	5x46	d2_off	0	100	No	Yes	No	No	7	6
318	5x47	Lig	d2_off	0	100	Yes	Yes	Yes	Yes	9	0
319	5x58	6x38	d2_off	0	100	Yes	Yes	No	No	9	8
320	5x68	6x28	d2_off	0	100	No	No	No	No	8	6
321	6x32	6x35	d2_off	0	100	No	No	No	No	9	8
322	6x40	7x49	d2_off	0	100	No	No	No	No	9	9
323	6x40	7x52	d2_off	0	100	No	No	No	No	9	8
324	6x44	7x45	d2_off	0	100	Yes	Yes	Yes	Yes	9	9
325	6x44	Lig	d2_off	0	100	Yes	Yes	Yes	Yes	9	0
326	6x45	6x49	d2_off	0	100	No	No	No	No	7	7
327	6x48	6x51	d2_off	0	100	Yes	Yes	Yes	Yes	9	8
328	6x48	7x42	d2_off	0	100	Yes	Yes	Yes	Yes	9	8
329	6x48	Lig	d2_off	0	100	Yes	Yes	Yes	Yes	9	0
330	6x54	7x34	d2_off	0	100	No	No	No	Yes	5	5
331	6x55	7x34	d2_off	0	100	No	No	No	Yes	8	5
332	6x57	E3.I403	d2_off	0	100	No	No	No	Yes	7	6
333	7x45	7x48	d2_off	0	100	Yes	Yes	No	No	9	7
334	7x49	7x53	d2_off	0	100	No	No	Yes	Yes	9	9
335	7x53	8x50	d2_off	0	100	Yes	Yes	Yes	Yes	9	9
336	7x55	7x56	d2_off	0	100	No	No	No	Yes	7	8
337	8x47	8x49	d2_off	0	100	No	No	No	Yes	9	7
338	8x48	8x49	d2_off	0	100	No	No	No	Yes	5	7
339	8x50	8x54	d2_off	0	100	Yes	Yes	No	Yes	9	9
340	1x33	1x35	d2_off	0	100	No	No	No	Yes	7	5
341	1x59	1x60	d2_off	0	100	No	No	No	Yes	7	8
342	3x26	E2.Q179	d2_off	0	100	No	Yes	No	No	6	1
343	3x37	4x53	d2_off	0	100	No	No	No	No	8	8
344	5x67	5x70	d2_off	0	100	No	No	No	No	6	7
345	6x29	6x30	d2_off	0	100	No	No	No	No	7	9
346	7x39	7x42	d2_off	0	100	Yes	Yes	Yes	Yes	8	8
347	6x59	6x60	d2_off	0	100	No	No	No	No	6	6
348	3x54	5x65	d2_off	0	66.6667	No	No	No	No	8	8
349	5x52	5x56	d2_off	0	0	No	No	No	No	4	5
350	5x36	E2x51	d2_off	0	66.6667	No	Yes	No	Yes	7	5
351	3x43	6x41	d2_off	0	33.3333	No	No	No	No	8	8
352	5x58	5x61	d2_off	0	33.3333	Yes	Yes	Yes	No	9	9
353	5x65	6x31	d2_off	0	33.3333	No	No	No	No	8	7
354	6x36	8x47	d2_off	0	33.3333	No	No	No	No	9	9
355	1x56	8x54	d2_off	0	0	No	No	No	Yes	9	9
356	3x26	E2x50	d2_off	0	66.6667	No	Yes	No	No	6	9
357	8x55	8x59	d2_off	0	66.6667	No	No	No	No	5	0
358	8x58	8x59	d2_off	0	33.3333	No	No	No	No	8	0
359	8x48	8x51	d2_off	0	33.3333	No	No	No	No	5	9
360	4x52	4x55	d2_off	0	33.3333	No	No	No	No	7	5
361	2x66	E1x49	d2_off	0	33.3333	No	Yes	No	No	5	4
362	1x54	2x44	d2_off	0	33.3333	No	No	No	No	7	7
363	1x35	7x39	d2_off	0	33.3333	No	Yes	Yes	Yes	5	8
364	1x34	1x35	d2_off	0	33.3333	No	No	No	Yes	5	5
365	3x23	3x27	d2_off	0	0	No	No	No	No	4	6
366	6x28	6x31	d2_off	0	33.3333	No	No	No	No	6	7
367	6x26	I2x50	d2_off	0	33.3333	No	No	No	No	0	9
368	5x67	5x71	d2_off	0	33.3333	No	No	No	No	6	6
369	1x43	2x58	d2_off	0	33.3333	No	No	No	No	8	9
370	4x64	E2.D178	d2_off	0	33.3333	No	No	No	No	7	3
371	8x51	8x55	d2_off	0	0	No	No	No	No	9	5
372	4x34	4x38	d2_off	0	33.3333	No	No	No	No	7	6
373	E3.C401	E3.D400	d2_off	0	33.3333	No	No	No	No	7	3
374	1x55	1x58	d2_off	0	33.3333	No	No	No	No	5	6
375	1x37	1x41	d2_off	0	33.3333	No	No	No	No	6	6
376	3x50	6x33	d2_off	0	0	No	Yes	No	No	9	9
377	6x32	7x56	d2_off	0	33.3333	No	No	No	Yes	9	8
378	4x35	4x39	d2_off	0	33.3333	No	No	No	Yes	7	6
379	E3.C401	E3.I403	d2_off	0	33.3333	No	No	No	Yes	7	6
380	5x66	5x69	d2_off	0	33.3333	No	No	No	No	6	6
381	1x40	2x61	d2_off	0	33.3333	No	No	No	No	4	8
382	5x45	5x49	d2_off	0	0	No	No	No	No	6	8
383	E2.A177	E2.E181	d2_off	0	33.3333	No	No	No	No	4	4
384	5x60	5x63	d2_off	0	0	No	No	No	No	7	5
385	3x56	I2x51	d2_off	0	0	No	No	No	No	6	6
386	3x51	3x56	d2_off	0	0	Yes	Yes	No	No	8	6
387	1x34	1x38	d2_off	0	0	No	No	No	No	5	5
388	6x46	6x47	d2_off	0	0	No	No	No	No	5	9
389	1x41	1x44	d2_off	0	0	No	No	No	No	6	5
390	1x37	1x40	d2_off	0	0	No	No	No	No	6	4
391	5x56	5x59	d2_off	0	0	No	No	No	No	5	4

Orange: nodes, hubs and links specific of d2_on network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of d2_off network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	d2_on Avg Int. Strength	d2_off Avg Int. Strength	d2_on Num Of Links	d2_off Num Of Links	ConSurf
1	1x52	d2_on	0	0	4	1	8
2	I1x50	d2_on	0	0	4	3	9
3	2x46	d2_on	100	0	4	2	9
4	2x50	d2_on	100	0	5	3	9
5	3x34	d2_on	50	0	4	3	7
6	I2x53	d2_on	100	0	5	0	8
7	4x61	d2_on	50	66.6667	4	3	8
8	E2.N175	d2_on	50	0	4	1	7
9	5x51	d2_on	0	0	4	1	7
10	5x61	d2_on	0	0	4	3	9
11	1x46	Shared	0	66.6667	4	4	8
12	1x50	Shared	100	66.6667	4	4	9
13	E1x50	Shared	100	100	6	6	9
14	E1x52	Shared	0	33.3333	4	4	7
15	3x49	Shared	100	100	5	4	8
16	3x51	Shared	50	0	4	4	8
17	5x39	Shared	100	66.6667	4	4	8
18	5x47	Shared	100	33.3333	6	4	9
19	5x58	Shared	100	33.3333	5	4	9
20	6x44	Shared	100	100	5	6	9
21	6x48	Shared	100	100	7	6	9
22	6x51	Shared	50	100	4	5	8
23	6x52	Shared	50	66.6667	5	5	8
24	7x30	Shared	0	0	4	4	6
25	7x39	Shared	100	66.6667	5	5	8
26	7x42	Shared	100	100	5	7	8
27	7x45	Shared	50	66.6667	4	4	9
28	7x53	Shared	100	100	4	4	9
29	8x50	Shared	100	100	4	6	9
30	Lig	Shared	100	100	12	15	0
31	1x35	d2_off	50	0	3	4	5
32	1x60	d2_off	0	0	3	4	8
33	2x66	d2_off	0	0	3	4	5
34	3x24	d2_off	0	66.6667	3	4	6
35	3x26	d2_off	0	0	3	4	6
36	3x50	d2_off	0	100	3	6	9
37	4x39	d2_off	0	0	1	4	6
38	E2x51	d2_off	0	66.6667	2	4	5
39	5x36	d2_off	0	66.6667	3	5	7
40	5x42	d2_off	0	33.3333	2	4	7
41	E3.I403	d2_off	0	0	3	4	6
42	7x34	d2_off	0	66.6667	3	4	5
43	7x56	d2_off	0	0	2	4	8
44	8x49	d2_off	0	0	2	4	7
45	8x54	d2_off	0	0	3	4	9

Orange: nodes, hubs and links specific of d2_on network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of d2_off network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	d2_on Recurrence	d2_off Recurrence	d2_on Hub1?	d2_off Hub1?	d2_on Hub2?	d2_off Hub2?	ConSurf1	ConSurf2
1	2x60	7x42	d2_on	52.4925	0.105739	No	No	Yes	Yes	8	8
2	3x36	Lig	d2_on	54.9263	1.64483	No	No	Yes	Yes	8	0
3	3x36	6x48	d2_on	55.3224	0	No	No	Yes	Yes	8	9
4	6x48	7x45	d2_on	60.4518	0	Yes	Yes	Yes	Yes	9	9
5	2x50	7x49	d2_on	41.6261	0	Yes	No	No	No	9	9
6	6x52	Lig	d2_on	85.733	2.43788	Yes	Yes	Yes	Yes	8	0
7	6x48	6x52	d2_on	61.8215	1.98555	Yes	Yes	Yes	Yes	9	8
8	1x50	7x50	d2_on	44.8186	8.606	Yes	Yes	No	No	9	9
9	1x49	7x50	d2_on	43.788	3.75374	No	No	No	No	9	9
10	1x48	1x49	d2_on	42.7507	1.87981	No	No	No	No	5	9
11	1x48	1x52	d2_on	41.7067	0	No	No	Yes	No	5	8
12	1x52	8x54	d2_on	37.9905	1.50972	Yes	No	No	Yes	8	9
13	7x54	8x54	d2_on	34.9324	1.91506	No	No	No	Yes	8	9
14	7x54	8x50	d2_on	32.8611	0	No	No	Yes	Yes	8	9
15	2x46	3x43	d2_on	40.4142	0	Yes	No	No	No	9	8
16	5x47	6x52	d2_on	33.4419	0.264348	Yes	Yes	Yes	Yes	9	8
17	5x47	6x44	d2_on	33.7541	0	Yes	Yes	Yes	Yes	9	9
18	2x46	7x49	d2_on	13.4748	0	Yes	No	No	No	9	9
19	2x40	8x50	d2_on	18.0872	3.45415	No	No	Yes	Yes	9	9
20	2x37	2x40	d2_on	17.0936	1.91506	No	No	No	No	8	9
21	2x37	I2x53	d2_on	15.875	0	No	No	Yes	No	8	8
22	3x43	7x53	d2_on	100	0	No	No	Yes	Yes	8	9
23	3x33	Lig	d2_on	31.0887	6.94942	No	No	Yes	Yes	8	0
24	3x33	4x57	d2_on	24.5661	0	No	No	No	No	8	9
25	3x34	4x57	d2_on	22.7164	2.48487	Yes	No	No	No	7	9
26	3x34	3x35	d2_on	13.3674	9.88662	Yes	No	No	No	7	7
27	2x60	3x28	d2_on	25.9827	0	No	No	No	No	8	7
28	3x28	E1x50	d2_on	20.6251	2.81384	No	No	Yes	Yes	7	9
29	2x61	2x65	d2_on	11.5076	0	No	No	No	No	8	6
30	3x50	7x53	d2_on	49.478	0	No	Yes	Yes	Yes	9	9
31	3x50	5x58	d2_on	47.1281	0	No	Yes	Yes	Yes	9	9
32	6x40	7x53	d2_on	48.3366	0	No	No	Yes	Yes	9	9
33	5x58	6x40	d2_on	47.0644	0	Yes	Yes	No	No	9	9
34	5x58	6x37	d2_on	73.1075	0	Yes	Yes	No	No	9	8
35	5x61	6x37	d2_on	59.626	0	Yes	No	No	No	9	8
36	3x51	3x55	d2_on	14.4483	1.83281	Yes	Yes	No	No	8	8
37	3x55	3x56	d2_on	11.5714	0	No	No	No	No	8	6
38	5x43	Lig	d2_on	10.8329	0	No	No	Yes	Yes	9	0
39	E2.N175	E2x52	d2_on	20.3297	0	Yes	No	No	No	7	7
40	5x62	6x37	d2_on	11.5613	0	No	No	No	No	7	8
41	5x65	6x30	d2_on	18.198	0	No	No	No	No	8	9
42	5x69	6x30	d2_on	10.5677	0	No	No	No	No	6	9
43	6x43	7x45	d2_on	13.1827	0	No	No	Yes	Yes	7	9
44	6x43	7x52	d2_on	10.2521	1.86219	No	No	No	No	7	8
45	7x34	E3.I403	d2_on	16.8653	0	No	Yes	No	Yes	5	6
46	7x30	E3.I403	d2_on	15.0089	6.50297	Yes	Yes	No	Yes	6	6
47	6x51	6x55	d2_on	10.289	4.59966	Yes	Yes	No	No	8	8
48	3x26	E2.N175	d2_on	11.2491	1.263	No	Yes	Yes	No	6	7
49	2x61	7x39	d2_on	13.3371	0	No	No	Yes	Yes	8	8
50	2x46	2x50	d2_on	20.5915	0	Yes	No	Yes	No	9	9
51	2x60	7x39	Shared	25.6739	16.7891	No	No	Yes	Yes	8	8
52	7x42	Lig	Shared	58.2463	37.2496	Yes	Yes	Yes	Yes	8	0
53	7x45	7x49	Shared	55.3493	65.8051	Yes	Yes	No	No	9	9
54	2x50	7x46	Shared	11.3868	14.6743	Yes	No	No	No	9	9
55	1x50	2x50	Shared	51.8446	19.9084	Yes	Yes	Yes	No	9	9
56	8x50	I1x50	Shared	11.1518	24.3847	Yes	Yes	Yes	No	9	9
57	6x44	6x48	Shared	61.1568	29.3603	Yes	Yes	Yes	Yes	9	9
58	3x43	6x44	Shared	98.9996	47.1891	No	No	Yes	Yes	8	9
59	2x46	3x42	Shared	30.8738	49.063	Yes	No	No	No	9	8
60	2x45	3x42	Shared	22.186	50.6256	No	No	No	No	9	8
61	2x45	4x46	Shared	13.3908	48.4051	No	No	No	No	9	9
62	4x42	4x46	Shared	11.1753	46.913	No	No	No	No	7	9
63	2x52	3x35	Shared	11.4774	12.3304	No	No	No	No	7	7
64	E1x50	E1x52	Shared	11.558	15.25	Yes	Yes	Yes	Yes	9	7
65	3x51	5x61	Shared	25.8888	20.4958	Yes	Yes	Yes	No	8	9
66	E2x52	Lig	Shared	23.2468	22.4344	No	No	Yes	Yes	7	0
67	5x58	6x41	Shared	14.4248	42.6129	Yes	Yes	No	No	9	8
68	5x61	5x65	Shared	23.4248	10.7384	Yes	No	No	No	9	8
69	7x34	Lig	Shared	20.0208	23.9558	No	Yes	Yes	Yes	5	0
70	1x39	7x39	d2_off	1.61133	22.1759	No	No	Yes	Yes	7	8
71	2x60	Lig	d2_off	0	17.8288	No	No	Yes	Yes	8	0
72	6x44	Lig	d2_off	0	100	Yes	Yes	Yes	Yes	9	0
73	3x39	6x44	d2_off	0	68.4368	No	No	Yes	Yes	9	9
74	2x50	3x39	d2_off	1.28907	27.6156	Yes	No	No	No	9	9
75	1x46	7x46	d2_off	8.90262	12.6123	Yes	Yes	No	No	8	9
76	7x39	7x42	d2_off	0	29.372	Yes	Yes	Yes	Yes	8	8
77	6x48	7x42	d2_off	0	24.8311	Yes	Yes	Yes	Yes	9	8
78	2x57	7x42	d2_off	5.87801	33.7955	No	No	Yes	Yes	9	8
79	1x50	2x51	d2_off	5.12605	10.6562	Yes	Yes	No	No	9	8
80	6x44	7x45	d2_off	0	70.6926	Yes	Yes	Yes	Yes	9	9
81	7x49	7x53	d2_off	0	61.0997	No	No	Yes	Yes	9	9
82	7x53	8x50	d2_off	0	65.4761	Yes	Yes	Yes	Yes	9	9
83	2x46	3x39	d2_off	0	50.326	Yes	No	No	No	9	9
84	4x39	4x42	d2_off	0	11.8839	No	Yes	No	No	6	7
85	8x49	I1x50	d2_off	2.55799	14.5509	No	Yes	Yes	No	7	9
86	8x47	8x50	d2_off	3.85377	27.8682	No	No	Yes	Yes	9	9
87	8x47	8x49	d2_off	0	14.6449	No	No	No	Yes	9	7
88	2x38	4x42	d2_off	0	35.1054	No	No	No	No	7	7
89	2x38	3x49	d2_off	0.0805667	26.6463	No	No	Yes	Yes	7	8
90	2x39	3x49	d2_off	0.0201417	13.329	No	No	Yes	Yes	8	8
91	2x39	3x50	d2_off	0	11.5667	No	No	No	Yes	8	9
92	2x53	2x57	d2_off	0	26.7462	No	No	No	No	8	9
93	2x53	3x35	d2_off	0	24.3729	No	No	No	No	8	7
94	2x63	Lig	d2_off	0	35.7046	No	No	Yes	Yes	7	0
95	2x63	E1x50	d2_off	1.96381	34.6707	No	No	Yes	Yes	7	9
96	2x62	E1x52	d2_off	2.17194	12.4655	No	No	Yes	Yes	6	7
97	2x62	2x66	d2_off	0.308839	10.9205	No	No	No	Yes	6	5
98	5x39	E2x52	d2_off	0	21.4298	Yes	Yes	No	No	8	7
99	3x29	5x39	d2_off	0	19.2093	No	No	Yes	Yes	6	8
100	3x29	E2x51	d2_off	0	18.146	No	No	No	Yes	6	5
101	3x40	6x44	d2_off	3.649	18.6454	No	No	Yes	Yes	9	9
102	3x40	5x50	d2_off	8.42929	17.1826	No	No	No	No	9	9
103	3x41	5x50	d2_off	0	12.6711	No	No	No	No	8	9
104	3x41	4x52	d2_off	2.2458	13.7402	No	No	No	No	8	7
105	3x43	6x41	d2_off	0	45.6911	No	No	No	No	8	8
106	5x58	5x61	d2_off	0	31.9626	Yes	Yes	Yes	No	9	9
107	3x51	5x60	d2_off	5.79744	10.85	Yes	Yes	No	No	8	7
108	5x36	E2x51	d2_off	0	12.2246	No	Yes	No	Yes	7	5
109	5x47	Lig	d2_off	0	10.6797	Yes	Yes	Yes	Yes	9	0
110	6x36	8x47	d2_off	0	12.677	No	No	No	No	9	9
111	6x36	7x56	d2_off	1.50727	11.2554	No	No	No	Yes	9	8
112	6x58	7x34	d2_off	1.59791	15.5554	No	No	No	Yes	5	5
113	6x58	E3.I403	d2_off	0.0234986	14.3629	No	No	No	Yes	5	6
114	8x48	8x49	d2_off	0	21.5649	No	No	No	Yes	5	7
115	1x35	7x39	d2_off	0	14.5392	No	Yes	Yes	Yes	5	8
116	8x48	8x51	d2_off	0	14.4217	No	No	No	No	5	9
117	8x51	8x55	d2_off	0	10.8324	No	No	No	No	9	5
118	1x37	1x40	d2_off	0	11.5726	No	No	No	No	6	4
119	1x40	2x61	d2_off	0	15.4086	No	No	No	No	4	8
120	1x39	2x61	d2_off	0.0402833	19.2328	No	No	No	No	7	8

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
2x56	3x32	Shared	6.81333	5.84	0	0	2	1
2x57	7x42	Shared	3.99333	10.18	0	0	2	1
2x60	7x39	Shared	4.90333	5.515	1	0	1	2
2x60	7x42	Shared	4.62667	7.57	1	0	1	1
2x60	Lig	d2_off	3.69	0	1	0	1	0
2x63	E1x50	Shared	9.87	2.28	0	0	1	2
2x63	Lig	d2_off	3.19333	0	0	0	1	0
3x28	E1x50	Shared	3.67667	6.015	0	0	2	2
3x29	E2x51	d2_off	3.07333	0	0	0	2	1
3x29	5x39	d2_off	3.05667	0	0	0	2	2
3x32	7x42	Shared	7.28333	7.475	1	1	1	1
3x32	Lig	Shared	17.52	13.91	1	1	1	0
3x33	4x61	Shared	3.97333	3.725	0	0	1	2
3x33	Lig	Shared	3.55333	12.365	0	0	1	0
3x36	Lig	Shared	12.5767	5.05	0	0	1	0
3x37	5x461	Shared	9.59	9.59	0	0	2	1
3x39	6x44	d2_off	6.31	0	0	0	2	1
3x40	6x44	Shared	3.9	5.025	0	1	2	1
3x43	6x44	Shared	6.09	4.875	0	0	2	1
4x61	5x39	Shared	5.27667	7.31	0	0	2	2
E2.L174	E2x51	d2_off	3.80667	0	0	0	2	1
5x39	E2x52	d2_off	4.18667	0	0	0	2	1
E2x52	Lig	Shared	4.73667	6.3	0	0	1	0
5x39	5x43	Shared	7.48667	5.945	0	0	2	1
5x44	6x52	Shared	4.4	6.61	0	0	2	1
5x461	Lig	Shared	3.26667	4.305	0	0	1	0
5x47	5x48	Shared	6.87667	6.19	1	1	1	2
5x47	6x52	Shared	28.58	27.865	1	1	1	1
5x47	Lig	d2_off	5.00667	0	1	1	1	0
6x44	6x48	Shared	8.68667	7.015	1	1	1	1
6x44	7x45	d2_off	10.07	0	1	1	1	2
6x44	Lig	d2_off	3.02667	0	1	1	1	0
6x48	6x51	d2_off	5.67667	0	1	1	1	1
6x48	6x52	Shared	3.34	7.52	1	1	1	1
6x48	7x41	Shared	12.67	5.625	1	1	1	2
6x48	7x42	d2_off	4.18	0	1	1	1	1
6x48	Lig	d2_off	17.08	0	1	1	1	0
6x51	6x52	Shared	7.86333	4.825	1	1	1	1
6x51	6x55	Shared	10.18	7.92	1	1	1	2
6x51	7x38	Shared	5.62	5.84	1	1	1	1
6x51	Lig	Shared	7.65333	14.42	1	1	1	0
6x52	Lig	Shared	8.64667	8.16	1	1	1	0
6x54	7x34	d2_off	3.74667	0	0	0	2	1
6x55	7x34	d2_off	11.6133	0	0	0	2	1
6x58	E3.I403	Shared	3.77667	10.62	0	1	2	2
6x58	7x34	Shared	3.87333	8.72	0	1	2	1
7x34	Lig	Shared	4.07667	6.685	0	1	1	0
7x38	7x42	Shared	3.33333	3.745	1	1	1	1
7x38	Lig	Shared	6.36667	6.175	1	1	1	0
7x42	Lig	Shared	6.03	8.68	1	1	1	0
7x39	7x42	d2_off	3.85667	0	1	2	2	1
5x36	E2x51	d2_off	2.83333	0	0	0	2	1
E2.E181	E2x51	Shared	2.73333	2.735	0	0	2	1
5x47	6x49	Shared	2.44	3.65	1	1	1	2
3x29	4x61	d2_on	0	5.215	0	0	2	2
3x29	E2x52	d2_on	0	3.84	0	0	2	1
3x33	4x57	d2_on	0	4.845	0	0	1	2
3x36	6x48	d2_on	0	5.22	0	0	1	1
3x40	6x48	d2_on	0	12.92	0	1	2	1
4x56	5x461	d2_on	0	6.965	4	0	2	1
E2.N175	E2x52	d2_on	0	7.08	0	0	2	1
E2x51	Lig	d2_on	0	6.875	0	0	1	0
5x36	5x39	d2_on	0	7.85	0	0	2	2
5x43	Lig	d2_on	0	6.26	0	0	1	0
5x44	5x48	d2_on	0	4.45	0	0	2	2
5x47	5x51	d2_on	0	8.04	1	1	1	2
5x47	6x44	d2_on	0	5.36	1	1	1	1
5x47	6x48	d2_on	0	4.01	1	1	1	1
5x51	6x44	d2_on	0	8.575	0	1	2	1
6x48	7x45	d2_on	0	9.605	1	1	1	2
7x34	E3.I403	d2_on	0	4.84	0	1	1	2
5x36	E2.N175	d2_on	0	4.085	0	0	2	2
2x60	3x28	d2_on	0	3.275	1	0	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	d2_off	6CM4-D₂-Risperidone 6LUQ-D₂-Haloperidol 7DFP-D₂-Spiperone
	d2_on	7JVR-D₂-Bromoergocryptine-Gi1/β1/γ2 8IRS-D₂-Rotigotine-Gi1/β1/γ2

Network Difference
Value	d2_on	d2_off
I_min	3.665	3.02333
Number of Linked Nodes	254	263
Number of Specific Nodes	4 (1.57%)	13 (4.94%)
Number of Shared Nodes	250 (98.43%)	250 (95.06%)
Number of Links	274	286
Number of Specific Links	105 (38.32%)	117 (40.91%)
Number of Shared Links	169 (61.68%)	169 (59.09%)
Number of Hubs	30	35
Number of Specific Hubs	10 (33.33%)	15 (42.86%)
Number of Shared Hubs	20 (66.67%)	20 (57.14%)
Average % Shared Neighbours (Jaccard)	46.94
Average % Shared Neighbours (Otsuka)	56.89
Average % Shared Neighbours (Overlap Coefficient)	67.90
Average % Shared Cliques (k3-6)	55.36
Graphlets Similarity	0.530965

Paths Difference
Value	d2_on	d2_off
Number Of Nodes in MetaPath	66	68
Specific Nodes in MetaPath	31 (46.97%)	33 (48.53%)
Shared Nodes in MetaPath	250 (98.43%)	250 (98.43%)
Number Of Links MetaPath	69	70
Specific Links in MetaPath	50 (72.46%)	51 (72.86%)
Shared Links in MetaPath	169 (61.68%)	169 (61.68%)
Number of Shortest Paths	65635	42176
Length Of Smallest Path	3	3
Average Path Length	13.8578	11.3797
Length of Longest Path	30	24
Minimum Path Strength	0.6475	0.79
Average Path Strength	6.55974	5.1597
Maximum Path Strength	18.0125	18.2217
Minimum Path Correlation	0.7	0.703333
Average Path Correlation	0.914361	0.9091
Maximum Path Correlation	0.99	0.99
Minimum % Of Corr. Nodes	4	5
Average % Of Corr. Nodes	40.5247	44.1614
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	44.5064	39.6197
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download d2_off_on.zip<

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