Orange: nodes, hubs and links specific of d3_on_gp network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of d3_off network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.


Index Hub Owner d3_on_gp Avg Int. Strength d3_off Avg Int. Strength d3_on_gp Num Of Links d3_off Num Of Links ConSurf
1G.HN.11 d3_on_gp3.728330402
2G.S1.02 d3_on_gp5.940405
3G.H1.01 d3_on_gp5.93750409
4G.H1.04 d3_on_gp4.69750407
5G.S2.08 d3_on_gp8.259170405
6G.S3.01 d3_on_gp5.821670404
7G.S3.03 d3_on_gp9.608330407
8G.S3.04 d3_on_gp6.38250406
9G.S3.05 d3_on_gp4.214170407
10G.S3.06 d3_on_gp7.369330505
11G.s3h2.03 d3_on_gp5.916670409
12G.H2.06 d3_on_gp5.800550609
13G.H2.07 d3_on_gp5.389330509
14G.h2s4.01 d3_on_gp7.202670509
15G.S4.03 d3_on_gp4.208330407
16G.s4h3.04 d3_on_gp7.283330508
17G.s4h3.05 d3_on_gp7.301330509
18G.H3.01 d3_on_gp7.15250409
19G.H3.09 d3_on_gp6.436110609
20G.H3.13 d3_on_gp4.260830405
21G.H3.17 d3_on_gp9.370670505
22G.H3.18 d3_on_gp7.010409
23G.S5.02 d3_on_gp4.26750406
24G.S5.03 d3_on_gp3.824170408
25G.S5.04 d3_on_gp4.415830409
26G.S5.05 d3_on_gp5.334670509
27G.S5.07 d3_on_gp5.56750409
28G.HG.04 d3_on_gp8.651670409
29G.HG.15 d3_on_gp4.705830407
30G.hgh4.02 d3_on_gp7.104290707
31G.hgh4.05 d3_on_gp8.134170407
32G.H4.03 d3_on_gp8.599170404
33G.H4.10 d3_on_gp11.05580406
34G.H4.15 d3_on_gp6.120830408
35G.H4.16 d3_on_gp3.898330403
36G.h4s6.02 d3_on_gp6.578330408
37G.S6.02 d3_on_gp5.307780607
38G.S6.04 d3_on_gp9.54250409
39G.H5.03 d3_on_gp6.490408
40G.H5.08 d3_on_gp6.07250408
41G.H5.13 d3_on_gp8.130830408
42G.H5.17 d3_on_gp7.561670405
43g.h1x1 d3_on_gp3.063330402
44g.h1x8 d3_on_gp3.298330407
45g.h1x11 d3_on_gp3.140830409
46g.h2x9 d3_on_gp2.83750404
47g.h2x11 d3_on_gp10.23330406
48g.ctx3 d3_on_gp6.040509
49g.ctx6 d3_on_gp3.522780606
50g.ctx14 d3_on_gp6.103330409
51g.ctx15 d3_on_gp7.980409
52g.ctx16 d3_on_gp5.312920808
531x60 d3_on_gp3.585836.24428
542x39 d3_on_gp4.478678.145528
552x40 d3_on_gp6.089175.33667439
562x50 d3_on_gp7.431677.96667439
573x51 d3_on_gp6.516674.39333439
584x41 d3_on_gp4.9260507
594x61 d3_on_gp6.207510.99427
605x47 d3_on_gp10.336110.3833639
615x51 d3_on_gp7.722675.735526
626x30 d3_on_gp5.592226.68638
636x52 d3_on_gp8.9073310.61537
647x39 d3_on_gp3.935838.09333438
657x54 d3_on_gp7.413333.24428
668x47 d3_on_gp4.367514.5419
67b.lhb1x6 d3_on_gp4.370403
68b.b1x4 d3_on_gp3.820830407
69b.l1x3 d3_on_gp8.2750609
70b.b2x1 d3_on_gp8.877330508
71b.b2x5 d3_on_gp6.898330607
72b.l3x2 d3_on_gp4.9840509
73b.b4x2 d3_on_gp4.681670408
74b.b4x4 d3_on_gp10.65580408
75b.b4x5 d3_on_gp4.7750407
76b.b4x6 d3_on_gp11.41440609
77b.b5x2 d3_on_gp6.405830407
78b.b5x3 d3_on_gp7.829440609
79b.b5x5 d3_on_gp5.849170405
80b.b5x7 d3_on_gp6.345830407
81b.l5x1 d3_on_gp4.6420508
82b.l5x5 d3_on_gp7.872860709
83b.l6x5 d3_on_gp6.259170404
84b.b7x1 d3_on_gp6.9850404
85b.l7x4 d3_on_gp6.210830409
86b.b8x3 d3_on_gp3.613330406
87b.b8x4 d3_on_gp5.6840506
88b.l8x3 d3_on_gp4.929170403
89b.l8x5 d3_on_gp3.4250403
90b.l8x8 d3_on_gp5.855830404
91b.l9x3 d3_on_gp8.705330509
92b.l9x6 d3_on_gp5.350420808
93b.b10x5 d3_on_gp5.337780609
94b.l10x1 d3_on_gp4.5650403
95b.b11x4 d3_on_gp4.822220609
96b.l11x2 d3_on_gp9.66250409
97b.b12x6 d3_on_gp9.739440608
98b.b12x7 d3_on_gp6.2150409
99b.b13x7 d3_on_gp8.287330507
100b.l13x3 d3_on_gp7.860560609
101b.b15x1 d3_on_gp8.281670409
102b.b15x2 d3_on_gp7.426670406
103b.l15x1 d3_on_gp4.190830407
104b.l15x2 d3_on_gp5.2640509
105b.b16x4 d3_on_gp9.103330506
106b.b16x5 d3_on_gp5.448670505
107b.b16x6 d3_on_gp9.060608
108b.b17x5 d3_on_gp7.725830407
109b.b17x7 d3_on_gp9.044170408
110b.l17x3 d3_on_gp9.682780609
111b.l17x6 d3_on_gp6.474670509
112b.b18x3 d3_on_gp4.796670508
113b.l18x1 d3_on_gp5.460560606
114b.l18x2 d3_on_gp5.789170407
115b.b19x2 d3_on_gp7.965330506
116b.b19x4 d3_on_gp5.943330408
117b.l19x2 d3_on_gp6.309330509
118b.b20x4 d3_on_gp10.39270508
119b.b20x6 d3_on_gp7.687330506
120b.b21x1 d3_on_gp9.340407
121b.b21x5 d3_on_gp5.084170404
122b.b21x7 d3_on_gp5.731110605
123b.l21x5 d3_on_gp4.088330404
124b.b22x5 d3_on_gp5.598670507
125b.l22x5 d3_on_gp7.96750409
126b.b23x1 d3_on_gp4.355830405
127b.b23x6 d3_on_gp7.647220607
128b.b24x2 d3_on_gp4.965830405
129b.b24x4 d3_on_gp7.663330506
130b.b24x5 d3_on_gp3.774170405
131b.b24x6 d3_on_gp6.201670408
132b.l24x2 d3_on_gp6.019170406
133b.b25x3 d3_on_gp5.645330505
134b.l25x3 d3_on_gp8.2440509
135b.b26x3 d3_on_gp4.53750406
136b.l26x5 d3_on_gp6.140405
137b.l27x1 d3_on_gp12.75170609
138b.l27x2 d3_on_gp7.151670409
139b.b28x2 d3_on_gp6.706670404
140b.b28x4 d3_on_gp8.465830406
141b.b28x6 d3_on_gp9.4720509
142b.b28x7 d3_on_gp7.661670409
1431x35 Shared2.25.028455
1441x39 Shared5.021675.198457
1451x46 Shared3.6054.24448
1461x50 Shared6.401336.665549
147E1x50 Shared6.398336.54167669
1483x49 Shared5.683337.5625449
1493x50 Shared5.699177.64857479
150I2x53 Shared7.892787.84668
1515x36 Shared5.623333.97446
1525x39 Shared7.846677.8075447
1535x58 Shared7.285835.6375449
1546x44 Shared6.068338.132459
1556x48 Shared6.745838.61667868
1566x51 Shared6.269529.52748
1576x55 Shared6.981339.775548
1587x42 Shared7.216.774558
1597x53 Shared5.543336.396459
1608x50 Shared8.986677.01143679
1618x54 Shared6.651675.038459
162Lig Shared9.9963312.291080
1631x53 d3_off6.876673.66149
164I1x50 d3_off7.665566.8325349
1652x57 d3_off7.393334.342258
1662x62 d3_off5.0755.864256
1672x66 d3_off4.611672.64245
1683x34 d3_off5.475564.93347
1693x35 d3_off5.305565.135345
1703x41 d3_off5.2455610.318357
1713x44 d3_off3.711113.09347
1727x34 d3_off4.114446.2375344
1737x52 d3_off3.075562.92348
   
Orange: nodes, hubs and links specific of d3_on_gp network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of d3_off network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Owner d3_on_gp Recurrence d3_off Recurrence d3_on_gp Hub1? d3_off Hub1? d3_on_gp Hub2? d3_off Hub2? ConSurf1 ConSurf2
1b.b3x2 b.b4x6 d3_on_gp23.11120NoNoYesNo59
2b.b2x5 b.b3x2 d3_on_gp23.29240YesNoNoNo75
3b.b2x3 b.b2x5 d3_on_gp59.56610NoNoYesNo67
4b.b26x2 b.b2x3 d3_on_gp59.72470NoNoNoNo76
5b.b26x1 b.b26x2 d3_on_gp60.04160NoNoNoNo97
6b.b26x1 b.l27x1 d3_on_gp60.20NoNoYesNo99
7G.H2.09 b.l27x1 d3_on_gp23.78470NoNoYesNo89
8G.H2.09 G.H3.17 d3_on_gp24.13230NoNoYesNo85
9G.H3.15 G.H3.17 d3_on_gp48.29990NoNoYesNo85
10G.H3.15 G.H3.18 d3_on_gp48.2190NoNoYesNo89
11G.H3.18 G.S4.02 d3_on_gp48.19790YesNoNoNo98
12G.S4.02 G.S5.02 d3_on_gp48.59790NoNoYesNo86
13G.H3.09 G.S5.02 d3_on_gp48.6570YesNoYesNo96
14G.H3.09 G.H4.15 d3_on_gp74.17030YesNoYesNo98
15G.H3.06 G.H4.15 d3_on_gp1000NoNoYesNo68
16G.H3.06 G.hgh4.02 d3_on_gp99.98730NoNoYesNo67
17G.HG.15 G.hgh4.02 d3_on_gp97.81180YesNoYesNo77
18G.HG.15 G.s4h3.04 d3_on_gp97.84760YesNoYesNo78
19G.s4h3.04 G.s4h3.05 d3_on_gp97.2940YesNoYesNo89
20G.s4h3.05 G.s4h3.06 d3_on_gp97.82980YesNoNoNo98
21G.H3.01 G.s4h3.06 d3_on_gp97.64560YesNoNoNo98
22G.H3.01 G.s1h1.04 d3_on_gp97.71420YesNoNoNo99
23G.s1h1.02 G.s1h1.04 d3_on_gp97.69450NoNoNoNo79
24G.s1h1.02 G.s1h1.05 d3_on_gp97.59470NoNoNoNo79
25G.H1.01 G.s1h1.05 d3_on_gp47.9640YesNoNoNo99
26G.H1.01 G.S1.06 d3_on_gp47.6990YesNoNoNo98
27G.S1.06 G.S4.03 d3_on_gp47.35940NoNoYesNo87
28G.S4.03 G.S5.03 d3_on_gp47.35730YesNoYesNo78
29G.H5.10 G.S5.03 d3_on_gp95.22010NoNoYesNo68
30G.H5.10 G.S6.02 d3_on_gp95.08040NoNoYesNo67
31G.H5.13 G.S6.02 d3_on_gp90.97850YesNoYesNo87
325x68 G.H5.13 d3_on_gp90.78040NoNoYesNo78
335x68 G.H5.16 d3_on_gp90.63680NoNoNoNo76
34G.H5.16 I2x50 d3_on_gp90.4930NoNoNoNo68
35G.H5.19 I2x50 d3_on_gp90.34910NoNoNoNo88
36G.H5.19 I2x53 d3_on_gp89.62810NoNoYesYes88
37b.l25x6 b.l27x1 d3_on_gp23.93430NoNoYesNo89
38G.H3.17 b.l25x6 d3_on_gp23.97250YesNoNoNo58
39G.S4.05 G.s1h1.05 d3_on_gp49.62740NoNoNoNo79
40G.H1.04 G.S4.05 d3_on_gp48.74110YesNoNoNo77
41G.H1.04 G.S5.05 d3_on_gp47.87160YesNoYesNo79
42G.S5.03 G.S5.05 d3_on_gp48.14180YesNoYesNo89
43b.b2x1 b.l27x1 d3_on_gp13.1270YesNoYesNo89
44b.b2x1 b.l3x1 d3_on_gp13.43750YesNoNoNo89
45b.l3x1 b.l5x5 d3_on_gp13.7640NoNoYesNo99
46G.H2.07 G.h2s4.01 d3_on_gp10.25840YesNoYesNo99
47G.H2.07 b.l9x6 d3_on_gp52.5860YesNoYesNo98
48G.H2.06 b.l9x6 d3_on_gp38.7640YesNoYesNo98
49G.H2.04 G.H2.07 d3_on_gp51.01750NoNoYesNo99
50G.H2.04 G.H3.08 d3_on_gp51.30930NoNoNoNo99
51G.H2.06 b.l17x6 d3_on_gp37.70630YesNoYesNo99
52G.H3.09 G.S4.04 d3_on_gp25.9580YesNoNoNo99
53G.H3.08 G.S4.04 d3_on_gp51.40790NoNoNoNo99
543x50 G.H5.23 d3_on_gp72.08740YesYesNoNo94
55G.H5.23 I2x53 d3_on_gp72.24030NoNoYesYes48
56b.l17x5 b.l17x6 d3_on_gp37.41690NoNoYesNo69
57b.l17x5 b.l19x2 d3_on_gp37.24340NoNoYesNo69
58b.l17x3 b.l19x2 d3_on_gp26.19730YesNoYesNo99
59b.b19x4 b.l17x3 d3_on_gp15.32710YesNoYesNo89
60b.b17x7 b.b20x6 d3_on_gp27.16180YesNoYesNo86
61b.b17x7 b.b21x1 d3_on_gp25.53260YesNoYesNo87
62b.1x19 b.b21x1 d3_on_gp20.03650NoNoYesNo67
63b.1x15 b.1x19 d3_on_gp17.81630NoNoNoNo76
64b.1x15 g.h1x11 d3_on_gp16.70560NoNoYesNo79
65b.1x11 g.h1x11 d3_on_gp12.25830NoNoYesNo89
66b.1x11 g.h1x12 d3_on_gp10.58880NoNoNoNo86
67b.b20x4 b.l17x3 d3_on_gp10.15640YesNoYesNo89
68b.b20x4 b.b20x6 d3_on_gp19.21130YesNoYesNo86
69b.b20x2 b.l19x2 d3_on_gp10.5160NoNoYesNo69
70b.b20x2 b.b20x4 d3_on_gp10.15620NoNoYesNo68
71b.b10x1 b.l9x6 d3_on_gp21.73620NoNoYesNo98
72b.b10x1 b.b11x5 d3_on_gp21.55330NoNoNoNo96
73b.b11x5 b.b14x3 d3_on_gp15.54410NoNoNoNo65
74b.l26x5 g.ctx4 d3_on_gp30.5720YesNoNoNo57
75g.ctx3 g.ctx4 d3_on_gp30.39550YesNoNoNo97
76g.ctx3 g.ctx6 d3_on_gp19.86830YesNoYesNo96
77b.l22x5 g.ctx6 d3_on_gp16.21310YesNoYesNo96
78b.l22x5 b.l24x2 d3_on_gp15.10260YesNoYesNo96
79b.h2x5 b.l24x2 d3_on_gp13.79150NoNoYesNo56
80b.h2x1 b.h2x5 d3_on_gp13.60370NoNoNoNo55
81b.b21x5 b.h2x1 d3_on_gp13.41590YesNoNoNo45
82b.b21x5 b.b21x7 d3_on_gp12.28650YesNoYesNo45
833x36 Lig d3_on_gp13.430NoNoYesYes70
843x36 6x48 d3_on_gp13.60341.72002NoNoYesYes78
855x54 6x44 d3_on_gp61.90860NoNoYesYes89
863x50 5x58 d3_on_gp64.46830YesYesYesYes99
875x47 6x52 d3_on_gp13.94018.94988YesNoYesNo97
885x47 6x44 d3_on_gp15.43860YesNoYesYes99
892x46 7x49 d3_on_gp10.00040NoNoNoNo99
903x43 7x53 d3_on_gp10.66890NoNoYesYes89
913x46 7x53 d3_on_gp14.00170NoNoYesYes99
922x60 3x28 d3_on_gp17.26510NoNoNoNo87
933x28 E1x50 d3_on_gp15.11030NoNoYesYes79
94b.b10x2 b.b14x3 d3_on_gp11.69260NoNoNoNo65
95b.b2x5 b.l26x1 d3_on_gp31.6330YesNoNoNo77
96b.l26x1 b.l26x3 d3_on_gp31.2730NoNoNoNo77
97b.l26x3 b.l26x5 d3_on_gp31.11010NoNoYesNo75
98b.b10x2 b.b6x2 d3_on_gp11.12850NoNoNoNo68
99b.b10x3 b.b6x2 d3_on_gp10.93960NoNoNoNo88
100b.b10x3 b.b11x4 d3_on_gp10.36680NoNoYesNo89
101G.H4.15 G.S5.04 d3_on_gp25.86720YesNoYesNo89
102G.S4.04 G.S5.04 d3_on_gp25.58480NoNoYesNo99
1032x60 7x42 Shared22.311714.793NoNoYesYes88
1047x42 Lig Shared25.170884.7502YesYesYesYes80
1056x44 6x48 Shared45.0854100YesYesYesYes98
1063x47 5x54 Shared62.474732.5693NoNoNoNo98
1073x47 5x58 Shared64.024611.7315NoNoYesYes99
1086x51 Lig Shared13.469357.164YesYesYesYes80
1096x48 6x51 Shared16.676454.0943YesYesYesYes88
1106x52 Lig Shared26.822356.4151YesNoYesYes70
1116x48 6x52 Shared13.962652.9175YesYesYesNo87
1122x46 3x43 Shared10.33451.4855NoNoNoNo98
1133x33 4x57 Shared10.812418.0561NoNoNoNo88
1143x33 Lig Shared17.285119.1425NoNoYesYes80
1151x39 2x60 d3_off4.4063213.5791YesYesNoNo78
1161x42 2x57 d3_off076.0472NoNoNoYes78
1172x57 7x42 d3_off1.4419377.5121NoYesYesYes88
1181x42 1x46 d3_off2.8599275.2119NoNoYesYes78
1191x46 7x46 d3_off071.7883YesYesNoNo89
1201x50 7x50 d3_off0.3625912.1101YesYesNoNo99
1211x50 2x50 d3_off6.7648727.8043YesYesYesNo99
1222x50 7x46 d3_off0.36312670.9119YesNoNoNo99
1231x50 2x47 d3_off0.3625912.1101YesYesNoNo99
1241x52 8x54 d3_off1.1940114.2334NoNoYesYes79
1251x53 8x54 d3_off021.7101NoYesYesYes99
1267x49 7x53 d3_off035.0753NoNoYesYes99
1272x50 7x49 d3_off8.1954743.4038YesNoNoNo99
1287x53 8x50 d3_off024.3931YesYesYesYes99
1293x43 6x44 d3_off052.938NoNoYesYes89
1302x46 3x42 d3_off050.0247NoNoNoNo99
1312x45 3x42 d3_off1.4739345.593NoNoNoNo99
1322x45 4x46 d3_off1.9529144.0993NoNoNoNo98
1334x42 4x46 d3_off042.5973NoNoNoNo78
1342x38 3x49 d3_off038.1285NoNoYesYes69
1352x38 4x42 d3_off0.39990141.0583NoNoNoNo67
1363x49 3x50 d3_off017.4759YesYesYesYes99
1373x44 5x54 d3_off1.024943.3133NoYesNoNo78
1383x41 3x44 d3_off047.7944NoYesNoYes77
1393x40 3x41 d3_off052.0657NoNoNoYes97
1403x40 6x44 d3_off055.0983NoNoYesYes99
1412x53 3x35 d3_off0.72276315.2127NoNoNoYes85
1422x53 2x57 d3_off016.3526NoNoNoYes88
1433x34 4x57 d3_off8.6606517.2085NoYesNoNo78
1443x29 E2x52 d3_off0.72254936.2069NoNoNoNo77
145E2x52 Lig d3_off037.2274NoNoYesYes70
1462x62 E1x50 d3_off012.3652NoYesYesYes69
1473x25 E1x50 d3_off7.2007420.3029NoNoYesYes99
1483x22 3x25 d3_off6.4816222.9405NoNoNoNo39
1493x22 E2.N173 d3_off030.4666NoNoNoNo35
1503x29 E2.N173 d3_off2.1674332.9026NoNoNoNo75
1515x43 Lig d3_off7.2025117.2825NoNoYesYes80
1525x43 5x461 d3_off016.155NoNoNoNo88
1533x37 5x461 d3_off1.4437614.9041NoNoNoNo88
1543x37 4x56 d3_off012.4105NoNoNoNo87
1554x56 5x42 d3_off010.1185NoNoNoNo76
1563x34 4x54 d3_off0.7273810.0527NoYesNoNo76
1573x49 I2x53 d3_off9.5002917.6446YesYesYesYes98
1583x47 5x57 d3_off1.7857319.949NoNoNoNo97
1593x51 5x57 d3_off1.3896418.3154YesNoNoNo97
1603x51 5x60 d3_off0.59617415.0235YesNoNoNo96
1613x50 6x30 d3_off011.2336YesYesYesNo98
1626x27 6x30 d3_off0.2278419.6733NoNoYesNo58
1636x26 6x27 d3_off013.2623NoNoNoNo05
1646x30 I2x53 d3_off011.3735YesNoYesYes88
1655x54 6x41 d3_off010.2173NoNoNoNo88
1666x51 7x34 d3_off0.55961410.3983YesYesNoYes84
1677x34 7x37 d3_off014.147NoYesNoNo46
1683x34 3x35 d3_off7.2232912.9084NoYesNoYes75

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Midway



Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Node1Node2OwnerNet1LinkStrengthNet2LinkStrengthComm1Comm2Node1ShellNode2Shell
3x32LigShared21.0816.47331710
3x33LigShared8.4114.180010
E2x52Ligd3_off16.1200010
5x43LigShared8.486.883330010
6x51LigShared15.4717.60671710
6x52LigShared8.66.50710
6x55LigShared12.717.861710
7x42LigShared7.4512.82671710
2x563x32Shared7.37.31721
2x567x42Shared3.793.366671721
2x577x42Shared8.387.983330021
2x607x42Shared5.054.206670021
3x327x42Shared9.27.666671711
3x334x57Shared6.464.310012
3x366x48Shared9.144.786670012
3x375x461Shared6.48.526670021
4x615x39Shared14.6110.960022
5x406x55Shared4.1512.91330021
5x435x461d3_off4.8900011
5x476x52Shared18.2218.93330721
6x486x51Shared5.013.341721
6x486x52Shared5.016.681721
6x516x55Shared12.444.146671711
6x517x34Shared5.163.436671712
6x557x34Shared9.85.806671712
7x347x37d3_off3.7501722
7x347x38d3_off6.2401721
3x29E2x52Shared3.077.170021
3x294x61d3_on_gp05.960022
3x334x61d3_on_gp04.470012
3x36Ligd3_on_gp08.353330010
5x395x43d3_on_gp012.770021
5x446x52d3_on_gp05.280021
5x446x55d3_on_gp04.180021
5x461Ligd3_on_gp04.663330010
5x476x48d3_on_gp03.340722
6x516x52d3_on_gp07.143331711
6x517x37d3_on_gp03.891712
6x517x38d3_on_gp04.323331711
7x38Ligd3_on_gp04.616670710

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
Id Description
d3_on_gp 7CMV-D3-PD128907-Gi1/β1/γ2
8IRT-D3-Rotigotine-Gi1/β1/γ2
7CMU-D3-Pramipexole-Gi1/β1/γ2
d3_off 3PBL-D3-Eticlopride
Network Difference
Value d3_on_gp d3_off
Imin 3.25 3.38
Number of Linked Nodes 870 245
Number of Specific Nodes 631 (72.53%) 6  (2.45%)
Number of Shared Nodes 239 (27.47%) 239  (97.55%)
Number of Links 1030 262
Number of Specific Links 872 (84.66%) 104  (39.69%)
Number of Shared Links 158 (15.34%) 158  (60.31%)
Number of Hubs 162 31
Number of Specific Hubs 142 (87.65%) 11  (35.48%)
Number of Shared Hubs 20 (12.35%) 20  (64.52%)
Average % Shared Neighbours (Jaccard) 12.84
Average % Shared Neighbours (Otsuka) 15.83
Average % Shared Neighbours (Overlap Coefficient) 18.97
Average % Shared Cliques (k3-6) 76.28
Graphlets Similarity 0.650199
Paths Difference
Value d3_on_gp d3_off
Number Of Nodes in MetaPath 109 65
Specific Nodes in MetaPath 90 (82.57%) 46  (70.77%)
Shared Nodes in MetaPath 239 (27.47%) 239  (27.47%)
Number Of Links MetaPath 114 66
Specific Links in MetaPath 102 (89.47%) 54  (81.82%)
Shared Links in MetaPath 158 (15.34%) 158  (15.34%)
Number of Shortest Paths 2460095 45353
Length Of Smallest Path 3 3
Average Path Length 43.1124 15.5404
Length of Longest Path 76 32
Minimum Path Strength 0.431667 1.485
Average Path Strength 6.05073 6.41625
Maximum Path Strength 25.5067 19.205
Minimum Path Correlation 0.703333 0.7
Average Path Correlation 0.986707 0.920305
Maximum Path Correlation 1 0.99
Minimum % Of Corr. Nodes 1.72414 3.7037
Average % Of Corr. Nodes 32.4499 44.1604
Maximum % Of Corr. Nodes 100 100
Minimum Path Hubs % 0 0
Average Path Hubs % 50.021 40.6126
Maximum Path Hubs % 100 100

Details about the values in these tables can be found in the corresponding documentation page .

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

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