psnGPCR

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Orange: nodes, hubs and links specific of d4_off_allo network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of d4_off network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	d4_off_allo Int. Strength	d4_off Int. Strength	d4_off_allo Hub1?	d4_off Hub1?	d4_off_allo Hub2?	d4_off Hub2?	ConSurf1	ConSurf2
1	1x42	7x43	d4_off_allo	4.47	0	No	No	No	No	7	6
2	2x42	3x45	d4_off_allo	4.16	0	Yes	Yes	No	No	8	8
3	2x43	8x50	d4_off_allo	3.77	0	No	No	Yes	Yes	8	8
4	2x50	Na	d4_off_allo	8.05	0	No	No	No	No	9	0
5	2x53	7x46	d4_off_allo	4.5	0	No	No	No	No	8	9
6	2x66	E1x51	d4_off_allo	5.32	0	Yes	No	No	No	6	4
7	3x24	E1x52	d4_off_allo	4.15	0	No	No	No	No	4	6
8	3x39	Na	d4_off_allo	5.94	0	No	No	No	No	9	0
9	3x47	5x54	d4_off_allo	4.6	0	No	No	No	No	9	8
10	3x50	6x34	d4_off_allo	3.72	0	Yes	Yes	No	No	9	8
11	4x41	I2x53	d4_off_allo	4.12	0	No	No	Yes	No	8	8
12	E2.E188	E2.P182	d4_off_allo	6.29	0	Yes	No	No	No	7	2
13	5x59	5x63	d4_off_allo	13.99	0	No	No	No	No	4	6
14	5x65	6x25	d4_off_allo	4.23	0	Yes	No	No	No	8	4
15	5x66	5x69	d4_off_allo	3.82	0	No	No	No	No	7	7
16	6x40	7x53	d4_off_allo	5.05	0	No	No	Yes	Yes	9	9
17	6x47	7x40	d4_off_allo	4.76	0	No	No	No	No	9	9
18	6x54	6x58	d4_off_allo	4.3	0	No	No	Yes	No	7	4
19	6x58	7x34	d4_off_allo	4.3	0	Yes	No	No	No	4	4
20	8x52	8x56	d4_off_allo	6.99	0	No	No	No	No	5	5
21	8x56	8x59	d4_off_allo	3.71	0	No	No	No	No	5	6
22	1x31	1x32	d4_off_allo	3.29	0	No	No	No	No	3	5
23	3x48	5x57	d4_off_allo	2.98	0	No	No	No	No	7	8
24	3x56	I2x51	d4_off_allo	2.98	0	No	No	No	No	6	7
25	6x36	6x37	d4_off_allo	2.98	0	No	No	No	No	8	8
26	6x41	6x45	d4_off_allo	2.98	0	No	No	No	No	7	7
27	3x31	3x34	d4_off_allo	2.89	0	Yes	No	No	No	7	8
28	2x65	2x66	d4_off_allo	2.87	0	Yes	No	Yes	No	6	6
29	5x37	6x59	d4_off_allo	2.77	0	No	No	No	No	6	7
30	5x49	5x53	d4_off_allo	2.77	0	No	No	No	No	7	7
31	7x32	7x35	d4_off_allo	2.64	0	No	No	No	No	3	7
32	1x32	2x65	d4_off_allo	1.84	0	No	No	Yes	No	5	6
33	1x43	1x44	d4_off_allo	1.76	0	No	No	No	No	7	5
34	6x49	6x53	d4_off_allo	1.59	0	No	No	No	No	7	7
35	1x36	2x61	d4_off_allo	1.49	0	No	No	No	No	8	8
36	1x57	I1x51	d4_off_allo	1.43	0	No	No	No	No	8	7
37	E2.E188	E2.V184	d4_off_allo	1.43	0	Yes	No	No	No	7	4
38	5x71	5x72	d4_off_allo	1.38	0	No	No	No	No	6	7
39	3x21	3x23	d4_off_allo	1.32	0	No	No	No	No	7	4
40	I2x54	I2x55	d4_off_allo	1.21	0	No	No	No	No	6	6
41	8x58	8x59	d4_off_allo	1.21	0	No	No	No	No	7	6
42	1x39	2x61	Shared	3.68	3.68	No	No	No	No	7	8
43	1x43	2x57	Shared	5.71	5.71	No	No	No	No	7	8
44	1x43	2x58	Shared	5.08	3.39	No	No	No	No	7	9
45	1x49	7x50	Shared	4.06	4.06	No	No	No	No	9	9
46	1x50	2x47	Shared	4.69	4.69	Yes	Yes	No	No	9	9
47	1x50	2x50	Shared	10.77	10.77	Yes	Yes	No	No	9	9
48	1x50	2x51	Shared	4.12	4.12	Yes	Yes	No	No	9	8
49	1x50	7x50	Shared	9.77	9.77	Yes	Yes	No	No	9	9
50	1x53	7x50	Shared	3.53	3.53	No	No	No	No	9	9
51	1x53	7x53	Shared	5.05	5.05	No	No	Yes	Yes	9	9
52	1x57	2x44	Shared	4.81	4.81	No	No	No	No	8	8
53	1x59	1x60	Shared	7.06	1.41	No	No	No	Yes	7	8
54	1x60	I1x50	Shared	5.3	5.3	No	Yes	Yes	Yes	8	8
55	1x60	8x53	Shared	11.41	5.7	No	Yes	No	Yes	8	8
56	I1x48	I1x51	Shared	10.51	12.85	No	No	No	No	8	7
57	2x40	I1x50	Shared	4.12	4.12	Yes	Yes	Yes	Yes	9	8
58	8x50	I1x50	Shared	12.18	10.96	Yes	Yes	Yes	Yes	8	8
59	8x53	I1x50	Shared	4.47	5.96	No	Yes	Yes	Yes	8	8
60	2x37	2x38	Shared	5.25	3.5	No	No	No	No	8	7
61	2x37	2x40	Shared	5.85	5.85	No	No	Yes	Yes	8	9
62	2x38	3x50	Shared	4.32	4.32	No	No	Yes	Yes	7	9
63	2x38	4x42	Shared	6.32	6.32	No	No	Yes	Yes	7	8
64	2x39	3x50	Shared	6.47	6.47	No	No	Yes	Yes	8	9
65	2x40	2x43	Shared	5.66	5.66	Yes	Yes	No	No	9	8
66	2x40	8x50	Shared	6.04	7.25	Yes	Yes	Yes	Yes	9	8
67	2x41	2x42	Shared	5.28	5.28	No	No	Yes	Yes	6	8
68	2x41	4x42	Shared	4.33	4.33	No	No	Yes	Yes	6	8
69	2x42	3x46	Shared	6.28	7.54	Yes	Yes	No	No	8	9
70	2x42	3x49	Shared	10.75	10.75	Yes	Yes	No	No	8	9
71	2x42	4x42	Shared	5.86	4.68	Yes	Yes	Yes	Yes	8	8
72	2x42	4x45	Shared	4.87	6.09	Yes	Yes	No	No	8	6
73	2x42	4x46	Shared	7.54	8.79	Yes	Yes	No	No	8	8
74	2x43	7x53	Shared	14.51	14.51	No	No	Yes	Yes	8	9
75	2x45	3x42	Shared	8.94	8.94	No	No	No	No	9	9
76	2x45	4x46	Shared	7.74	6.19	No	No	No	No	9	8
77	2x45	4x50	Shared	6.18	6.18	No	No	Yes	Yes	9	9
78	2x46	3x43	Shared	4.15	4.15	No	No	No	No	9	9
79	2x50	7x46	Shared	11.78	11.78	No	No	No	No	9	9
80	2x52	3x35	Shared	4.15	4.15	No	No	No	No	7	7
81	2x53	2x56	Shared	5.96	5.96	No	No	No	No	8	8
82	2x53	2x57	Shared	6.92	5.54	No	No	No	No	8	8
83	2x551	3x31	Shared	5.65	5.65	No	No	Yes	No	6	7
84	2x57	7x42	Shared	8.21	8.21	No	No	Yes	Yes	8	8
85	2x59	3x28	Shared	5.54	8.3	No	No	No	No	6	7
86	2x60	2x64	Shared	12.83	10.49	Yes	Yes	No	No	8	6
87	2x60	7x39	Shared	14.03	13.03	Yes	Yes	No	No	8	8
88	2x60	7x42	Shared	11.35	11.35	Yes	Yes	Yes	Yes	8	8
89	2x60	Lig	Shared	6.72	8.97	Yes	Yes	Yes	Yes	8	0
90	2x62	2x66	Shared	16.91	11.27	No	No	Yes	No	7	6
91	2x64	7x35	Shared	5.75	5.75	No	No	No	No	6	7
92	2x64	7x39	Shared	8.72	9.81	No	No	No	No	6	8
93	E1x50	E1x52	Shared	7.97	7.97	Yes	Yes	No	No	8	6
94	3x24	E1x50	Shared	5.69	5.69	No	No	Yes	Yes	4	8
95	3x25	E1x50	Shared	6.53	5.22	No	No	Yes	Yes	9	8
96	3x28	E1x50	Shared	4.56	3.42	No	No	Yes	Yes	7	8
97	E1x50	E2x50	Shared	5.22	5.22	Yes	Yes	No	No	8	9
98	3x21	3x22	Shared	5.34	3.56	No	No	No	No	7	4
99	3x25	3x29	Shared	4.86	4.86	No	No	Yes	Yes	9	7
100	3x25	E2x50	Shared	7.28	7.28	No	No	No	No	9	9
101	3x26	4x64	Shared	5.03	5.03	No	No	No	No	7	6
102	3x28	Lig	Shared	5.94	6.79	No	No	Yes	Yes	7	0
103	3x29	E2x52	Shared	5.65	5.65	Yes	Yes	No	No	7	7
104	3x30	4x62	Shared	4.73	3.15	No	No	No	No	8	8
105	3x31	3x35	Shared	7.07	7.07	Yes	No	No	No	7	7
106	3x32	7x42	Shared	8.05	8.05	No	No	Yes	Yes	9	8
107	3x32	Lig	Shared	23.31	19.98	No	No	Yes	Yes	9	0
108	3x33	5x39	Shared	6.31	3.79	No	No	Yes	Yes	9	8
109	3x33	Lig	Shared	10.97	11.88	No	No	Yes	Yes	9	0
110	3x36	6x48	Shared	7.84	7.84	No	No	Yes	Yes	8	9
111	3x36	Lig	Shared	4.87	4.87	No	No	Yes	Yes	8	0
112	3x37	3x41	Shared	7.78	7.78	Yes	Yes	No	No	8	7
113	3x37	4x53	Shared	6.4	6.4	Yes	Yes	No	No	8	8
114	3x37	4x56	Shared	4.76	4.76	Yes	Yes	No	No	8	8
115	3x37	5x461	Shared	9.59	9.59	Yes	Yes	No	No	8	8
116	3x38	4x50	Shared	7.78	7.78	No	No	Yes	Yes	8	9
117	3x40	6x44	Shared	10.05	11.3	No	No	Yes	Yes	9	9
118	3x41	4x53	Shared	6.61	6.61	No	No	No	No	7	8
119	3x42	4x49	Shared	11.7	10.24	No	No	No	No	9	8
120	3x42	4x50	Shared	6.78	3.39	No	No	Yes	Yes	9	9
121	3x43	6x44	Shared	6.09	4.87	No	No	Yes	Yes	9	9
122	3x44	5x54	Shared	8.1	4.86	No	No	No	No	8	8
123	3x45	4x45	Shared	4.73	3.15	No	No	No	No	8	6
124	3x46	5x58	Shared	8.46	8.46	No	No	Yes	Yes	9	9
125	3x47	5x57	Shared	7.51	6.01	No	No	No	No	9	8
126	3x47	5x58	Shared	10.17	10.17	No	No	Yes	Yes	9	9
127	3x49	3x50	Shared	11.91	10.72	No	No	Yes	Yes	9	9
128	3x49	4x42	Shared	11.75	11.75	No	No	Yes	Yes	9	8
129	3x50	3x53	Shared	5.53	5.53	Yes	Yes	No	No	9	9
130	3x51	3x55	Shared	5.55	5.55	Yes	Yes	No	No	8	7
131	3x51	5x57	Shared	4.87	3.65	Yes	Yes	No	No	8	8
132	3x51	5x61	Shared	3.89	3.89	Yes	Yes	No	No	8	9
133	3x54	5x65	Shared	5.96	10.43	No	No	Yes	No	8	8
134	I2x51	I2x53	Shared	4.69	4.69	No	No	Yes	No	7	8
135	4x39	I2x53	Shared	5.09	5.09	No	No	Yes	No	5	8
136	4x39	4x41	Shared	7.91	5.27	No	No	No	No	5	8
137	4x40	4x43	Shared	6.07	3.64	No	No	No	No	5	6
138	4x41	4x42	Shared	5.84	5.84	No	No	Yes	Yes	8	8
139	4x46	4x47	Shared	3.53	1.76	No	No	No	No	8	5
140	4x56	5x42	Shared	6.31	5.05	No	No	No	No	8	6
141	4x60	5x39	Shared	5.56	5.56	No	No	Yes	Yes	8	8
142	4x61	5x39	Shared	6.31	6.31	No	No	Yes	Yes	8	8
143	5x36	E2.L174	Shared	6.79	6.79	No	No	No	No	5	6
144	5x39	E2.L174	Shared	5.86	5.86	Yes	Yes	No	No	8	6
145	E2.E188	E2.N175	Shared	15.77	22.35	Yes	No	No	No	7	6
146	E2.D176	E2.E188	Shared	6.5	3.9	No	No	Yes	No	6	7
147	E2.V184	E2x51	Shared	13.08	14.38	No	No	No	No	4	5
148	E2x52	Lig	Shared	6.79	5.94	No	No	Yes	Yes	7	0
149	5x37	E3.P373	Shared	12.97	12.97	No	No	No	No	6	1
150	5x39	5x42	Shared	4.96	4.96	Yes	Yes	No	No	8	6
151	5x39	5x43	Shared	5.09	5.09	Yes	Yes	No	No	8	9
152	5x41	6x56	Shared	4.61	4.61	No	No	Yes	Yes	7	7
153	5x41	6x60	Shared	4.47	4.47	No	No	No	No	7	4
154	5x42	5x46	Shared	5.38	6.72	No	No	No	No	6	6
155	5x43	5x461	Shared	4.89	4.89	No	No	No	No	9	8
156	5x43	Lig	Shared	6.45	6.45	No	No	Yes	Yes	9	0
157	5x44	6x52	Shared	3.96	3.96	No	No	Yes	Yes	8	8
158	5x44	6x56	Shared	7.74	7.74	No	No	Yes	Yes	8	7
159	5x461	Lig	Shared	3.68	3.68	No	No	Yes	Yes	8	0
160	5x47	5x48	Shared	9.65	9.65	Yes	Yes	No	No	9	8
161	5x47	5x51	Shared	8.38	8.38	Yes	Yes	No	No	9	7
162	5x47	6x49	Shared	5.19	5.19	Yes	Yes	No	No	9	7
163	5x47	6x52	Shared	24.65	25.72	Yes	Yes	Yes	Yes	9	8
164	5x48	6x56	Shared	6.28	6.28	No	No	Yes	Yes	8	7
165	5x54	5x58	Shared	4.79	5.99	No	No	Yes	Yes	8	9
166	5x58	6x41	Shared	5.05	5.05	Yes	Yes	No	No	9	7
167	5x62	6x34	Shared	9.95	9.95	No	No	No	No	7	8
168	5x62	6x38	Shared	5.78	5.78	No	No	No	No	7	7
169	5x65	6x30	Shared	9.28	7.95	Yes	No	No	No	8	8
170	5x65	6x31	Shared	6.07	4.86	Yes	No	Yes	Yes	8	7
171	5x66	6x31	Shared	16.35	16.35	No	No	Yes	Yes	7	7
172	5x68	6x25	Shared	12.76	10.44	No	No	No	No	7	4
173	5x69	6x28	Shared	6.55	6.55	No	No	No	No	7	5
174	5x69	6x31	Shared	13.96	15.12	No	No	Yes	Yes	7	7
175	6x25	6x30	Shared	9.45	6.75	No	No	No	No	4	8
176	6x27	6x29	Shared	6.47	6.47	No	No	No	No	5	7
177	6x36	8x47	Shared	8.87	5.91	No	No	No	No	8	9
178	6x39	7x52	Shared	4.61	6.14	No	No	No	No	7	9
179	6x39	7x56	Shared	11.8	10.49	No	No	No	No	7	8
180	6x40	7x49	Shared	7.39	7.39	No	No	No	No	9	9
181	6x44	6x48	Shared	15.03	17.04	Yes	Yes	Yes	Yes	9	9
182	6x44	7x45	Shared	7.25	7.25	Yes	Yes	No	No	9	9
183	6x47	7x45	Shared	9.45	9.45	No	No	No	No	9	9
184	6x48	6x51	Shared	12.03	11.02	Yes	Yes	Yes	Yes	9	8
185	6x48	6x52	Shared	6.01	6.01	Yes	Yes	Yes	Yes	9	8
186	6x48	7x41	Shared	11.26	11.26	Yes	Yes	No	No	9	8
187	6x48	7x45	Shared	6.78	6.78	Yes	Yes	No	No	9	9
188	6x50	7x37	Shared	3.53	3.53	No	No	No	No	9	7
189	6x51	6x52	Shared	9.65	9.65	Yes	Yes	Yes	Yes	8	8
190	6x51	6x55	Shared	18.1	22.63	Yes	Yes	No	No	8	7
191	6x51	7x37	Shared	3.93	3.93	Yes	Yes	No	No	8	7
192	6x51	7x38	Shared	6.49	3.89	Yes	Yes	No	No	8	6
193	6x51	Lig	Shared	14.2	14.2	Yes	Yes	Yes	Yes	8	0
194	6x52	Lig	Shared	7.47	6.72	Yes	Yes	Yes	Yes	8	0
195	6x54	E3.V377	Shared	6.41	6.41	No	No	Yes	Yes	7	5
196	6x54	7x37	Shared	6.41	6.41	No	No	No	No	7	7
197	6x55	6x58	Shared	3.71	3.71	No	No	Yes	No	7	4
198	6x56	6x60	Shared	4.28	5.71	Yes	Yes	No	No	7	4
199	6x58	E3.V377	Shared	8.6	8.6	Yes	No	Yes	Yes	4	5
200	6x61	E3.C375	Shared	7.28	7.28	No	No	No	No	8	7
201	7x30	E3.V377	Shared	3.53	3.53	No	No	Yes	Yes	6	5
202	7x33	E3.V377	Shared	4.47	4.47	No	No	Yes	Yes	6	5
203	7x30	7x33	Shared	4.93	4.93	No	No	No	No	6	6
204	7x38	7x42	Shared	4.99	4.99	No	No	Yes	Yes	6	8
205	7x42	Lig	Shared	5.75	5.75	Yes	Yes	Yes	Yes	8	0
206	7x49	7x53	Shared	9.3	8.14	No	No	Yes	Yes	9	9
207	7x53	8x50	Shared	8.25	7.22	Yes	Yes	Yes	Yes	9	8
208	7x54	8x54	Shared	10.38	10.38	No	No	No	No	8	8
209	7x55	7x56	Shared	11.8	11.8	No	No	No	No	6	8
210	8x47	8x49	Shared	10.52	10.52	No	No	No	No	9	7
211	8x47	8x50	Shared	7.25	8.46	No	No	Yes	Yes	9	8
212	8x52	8x55	Shared	14.46	16.87	No	No	No	No	5	5
213	2x59	2x62	Shared	3.52	2.34	No	No	No	No	6	7
214	1x46	2x54	Shared	3.39	3.39	Yes	Yes	No	No	8	8
215	3x30	4x61	Shared	3.39	3.39	No	No	No	No	8	8
216	3x33	4x57	Shared	3.39	3.39	No	No	No	No	9	9
217	3x40	5x50	Shared	3.39	3.39	No	No	No	No	9	9
218	5x40	6x59	Shared	3.39	3.39	No	No	No	No	7	7
219	6x57	E3.C375	Shared	3.38	3.38	No	No	No	No	7	7
220	5x49	5x50	Shared	3.28	3.28	No	No	No	No	7	9
221	1x46	7x46	Shared	3.23	3.23	Yes	Yes	No	No	8	9
222	1x56	8x53	Shared	3.23	3.23	No	No	No	Yes	9	8
223	3x52	3x56	Shared	3.21	3.21	No	No	No	No	5	6
224	5x62	6x31	Shared	3.21	3.21	No	No	Yes	Yes	7	7
225	1x47	2x54	Shared	3.15	3.15	No	No	No	No	7	8
226	2x56	3x31	Shared	3.04	3.04	No	No	Yes	No	8	7
227	8x48	8x49	Shared	3.02	4.53	No	No	No	No	5	7
228	1x51	2x51	Shared	3	3	No	No	No	No	6	8
229	3x21	3x24	Shared	3	1.5	No	No	No	No	7	4
230	1x42	1x46	Shared	2.98	2.98	No	No	Yes	Yes	7	8
231	5x40	E2x52	Shared	2.98	2.98	No	No	No	No	7	7
232	5x45	5x49	Shared	2.98	2.98	No	No	No	No	6	7
233	1x39	7x39	Shared	2.81	2.81	No	No	No	No	7	8
234	1x47	2x55	Shared	2.77	4.15	No	No	No	No	7	6
235	3x51	5x60	Shared	2.77	2.77	Yes	Yes	No	No	8	7
236	5x55	6x45	Shared	2.77	2.77	No	No	No	No	6	7
237	5x36	5x38	Shared	2.66	3.99	No	No	No	No	5	5
238	1x57	8x50	Shared	2.62	2.62	No	No	Yes	Yes	8	8
239	6x36	7x56	Shared	2.62	2.62	No	No	No	No	8	8
240	2x49	4x50	Shared	2.59	2.59	No	No	Yes	Yes	9	9
241	5x59	5x60	Shared	2.59	1.3	No	No	No	No	4	7
242	3x41	4x52	Shared	2.44	2.44	No	No	No	No	7	6
243	5x68	6x26	Shared	2.35	2.35	No	No	No	No	7	5
244	5x56	5x59	Shared	2.28	2.28	No	No	No	No	5	4
245	1x38	1x39	Shared	2.11	2.11	No	No	No	No	4	7
246	2x67	E1.G99	Shared	2.11	2.11	No	No	No	No	7	6
247	4x38	I2x57	Shared	2.11	2.11	No	No	No	No	8	7
248	1x48	1x49	Shared	1.95	1.95	No	No	No	No	5	9
249	7x30	7x31	Shared	1.95	1.95	No	No	No	No	6	3
250	5x51	5x52	Shared	1.88	1.88	No	No	No	No	7	5
251	6x61	E3.P373	Shared	1.88	1.88	No	No	No	No	8	1
252	4x59	4x60	Shared	1.87	1.87	No	No	No	No	6	8
253	2x63	E1.G99	Shared	1.86	1.86	No	No	No	No	7	6
254	1x37	1x38	Shared	1.84	3.68	No	No	No	No	5	4
255	2x63	Lig	Shared	1.84	1.84	No	No	Yes	Yes	7	0
256	3x54	5x64	Shared	1.84	1.84	No	No	No	No	8	7
257	6x41	6x42	Shared	1.84	1.84	No	No	No	No	7	7
258	1x54	2x47	Shared	1.81	1.81	No	No	No	No	8	9
259	6x61	E3.A374	Shared	1.81	1.81	No	No	No	No	8	5
260	1x45	7x47	Shared	1.79	1.79	No	No	No	No	5	8
261	3x56	I2x50	Shared	1.77	1.77	No	No	No	No	6	9
262	6x28	6x32	Shared	1.74	1.74	No	No	No	No	5	8
263	1x35	2x65	Shared	1.7	1.7	No	No	Yes	No	6	6
264	1x46	7x47	Shared	1.7	1.7	Yes	Yes	No	No	8	8
265	6x43	7x52	Shared	1.62	1.62	No	No	No	No	8	9
266	3x34	4x54	Shared	1.61	1.61	No	No	No	No	8	7
267	7x51	7x55	Shared	1.6	1.6	No	No	No	No	6	6
268	1x55	1x59	Shared	1.59	1.59	No	No	No	No	6	7
269	6x47	7x48	Shared	1.59	1.59	No	No	No	No	9	7
270	6x53	6x57	Shared	1.59	1.59	No	No	No	No	7	7
271	3x27	4x62	Shared	1.58	1.58	No	No	No	No	7	8
272	7x33	7x36	Shared	1.58	1.58	No	No	No	No	6	5
273	5x70	6x26	Shared	1.54	1.54	No	No	No	No	5	5
274	2x66	E1x49	Shared	1.52	1.52	Yes	No	No	No	6	5
275	1x36	1x40	Shared	1.49	1.49	No	No	No	No	8	6
276	1x36	2x65	Shared	1.49	1.49	No	No	Yes	No	8	6
277	1x37	1x41	Shared	1.49	1.49	No	No	No	No	5	4
278	4x38	I2x53	Shared	1.45	1.45	No	No	Yes	No	8	8
279	3x29	E2.N175	Shared	1.4	2.8	Yes	Yes	No	No	7	6
280	3x26	3x29	Shared	1.39	1.39	No	No	Yes	Yes	7	7
281	6x29	I3.A228	Shared	1.38	1.38	No	No	No	No	7	5
282	I2x55	I2x56	Shared	1.17	1.17	No	No	No	No	6	5
283	8x51	8x55	Shared	1.07	12.79	No	No	No	No	8	5
284	2x53	7x42	d4_off	0	4.69	No	No	Yes	Yes	8	8
285	2x60	7x38	d4_off	0	3.89	Yes	Yes	No	No	8	6
286	3x23	3x26	d4_off	0	13.1	No	No	No	No	4	7
287	3x38	4x53	d4_off	0	3.42	No	No	No	No	8	8
288	3x52	4x41	d4_off	0	3.92	No	No	No	No	5	8
289	4x60	E2.L174	d4_off	0	3.28	No	No	No	No	8	6
290	5x36	5x39	d4_off	0	3.45	No	No	Yes	Yes	5	8
291	5x63	5x67	d4_off	0	20.26	No	No	No	No	6	5
292	5x64	5x67	d4_off	0	4.5	No	No	No	No	7	5
293	6x32	6x35	d4_off	0	6.19	No	No	No	No	8	7
294	6x34	6x37	d4_off	0	4.24	No	No	No	No	8	8
295	6x49	6x50	d4_off	0	3.5	No	No	No	No	7	9
296	6x50	7x40	d4_off	0	4.93	No	No	No	No	9	9
297	7x43	7x48	d4_off	0	4.47	No	No	No	No	6	7
298	3x34	4x57	d4_off	0	3.22	No	No	No	No	8	9
299	7x34	E3.V377	d4_off	0	3.21	No	No	Yes	Yes	4	5
300	3x54	5x61	d4_off	0	3.17	No	No	No	No	8	9
301	5x51	6x45	d4_off	0	3.17	No	No	No	No	7	7
302	8x53	8x56	d4_off	0	3.04	No	Yes	No	No	8	5
303	1x60	I1x49	d4_off	0	3.02	No	Yes	No	No	8	7
304	2x46	3x39	d4_off	0	3	No	No	No	No	9	9
305	5x48	6x53	d4_off	0	2.62	No	No	No	No	8	7
306	6x27	6x28	d4_off	0	1.82	No	No	No	No	5	5
307	I2x56	I2x57	d4_off	0	1.64	No	No	No	No	5	7
308	3x47	3x48	d4_off	0	1.62	No	No	No	No	9	7
309	2x61	2x65	d4_off	0	1.6	No	No	Yes	No	8	6
310	8x48	8x52	d4_off	0	1.56	No	No	No	No	5	5
311	1x60	I1x48	d4_off	0	1.16	No	Yes	No	No	8	8
312	8x54	8x55	d4_off	0	1.07	No	No	No	No	8	5

Orange: nodes, hubs and links specific of d4_off_allo network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of d4_off network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	d4_off_allo Avg Int. Strength	d4_off Avg Int. Strength	d4_off_allo Num Of Links	d4_off Num Of Links	ConSurf
1	2x65	d4_off_allo	1.975	1.59667	4	3	6
2	2x66	d4_off_allo	6.655	6.395	4	2	6
3	3x31	d4_off_allo	4.6625	5.25333	4	3	7
4	I2x53	d4_off_allo	3.8375	3.74333	4	3	8
5	E2.E188	d4_off_allo	7.4975	13.125	4	2	7
6	5x65	d4_off_allo	6.385	7.74667	4	3	8
7	6x58	d4_off_allo	5.2275	6.155	4	2	4
8	1x46	Shared	2.825	2.825	4	4	8
9	1x50	Shared	7.3375	7.3375	4	4	9
10	I1x50	Shared	6.5175	6.585	4	4	8
11	2x40	Shared	5.4175	5.72	4	4	9
12	2x42	Shared	6.39143	7.18833	7	6	8
13	2x60	Shared	11.2325	9.546	4	5	8
14	E1x50	Shared	5.994	5.504	5	5	8
15	3x29	Shared	3.325	3.675	4	4	7
16	3x37	Shared	7.1325	7.1325	4	4	8
17	3x50	Shared	6.39	6.76	5	4	9
18	3x51	Shared	4.27	3.965	4	4	8
19	4x42	Shared	6.82	6.584	5	5	8
20	4x50	Shared	5.8325	4.985	4	4	9
21	5x39	Shared	5.68167	5.00286	6	7	8
22	5x47	Shared	11.9675	12.235	4	4	9
23	5x58	Shared	7.1175	7.4175	4	4	9
24	6x31	Shared	9.8975	9.885	4	4	7
25	6x44	Shared	9.605	10.115	4	4	9
26	6x48	Shared	9.825	9.99167	6	6	9
27	6x51	Shared	10.7333	10.8867	6	6	8
28	6x52	Shared	10.348	10.412	5	5	8
29	6x56	Shared	5.7275	6.085	4	4	7
30	E3.V377	Shared	5.7525	5.244	4	5	5
31	7x42	Shared	7.67	7.17333	5	6	8
32	7x53	Shared	8.432	8.73	5	4	9
33	8x50	Shared	6.685	7.302	6	5	8
34	Lig	Shared	8.16583	8.08917	12	12	0
35	1x60	d4_off	7.92333	3.318	3	5	8
36	8x53	d4_off	6.37	4.4825	3	4	8

Orange: nodes, hubs and links specific of d4_off_allo network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of d4_off network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	d4_off_allo Recurrence	d4_off Recurrence	d4_off_allo Hub1?	d4_off Hub1?	d4_off_allo Hub2?	d4_off Hub2?	ConSurf1	ConSurf2
1	2x57	7x42	d4_off_allo	100	4.13637	No	No	Yes	Yes	8	8
2	2x53	2x57	d4_off_allo	99.9199	0.0727179	No	No	No	No	8	8
3	2x53	7x46	d4_off_allo	99.3868	0	No	No	No	No	8	9
4	2x38	3x50	d4_off_allo	27.0841	1.40303	No	No	Yes	Yes	7	9
5	3x33	5x39	d4_off_allo	10.4276	7.08358	No	No	Yes	Yes	9	8
6	5x43	Lig	d4_off_allo	11.2121	7.43434	No	No	Yes	Yes	9	0
7	3x50	6x34	d4_off_allo	23.6202	0	Yes	Yes	No	No	9	8
8	5x62	6x34	d4_off_allo	22.2584	2.51519	No	No	No	No	7	8
9	5x62	6x31	d4_off_allo	19.4161	5.09026	No	No	Yes	Yes	7	7
10	4x41	I2x53	d4_off_allo	10.5602	0	No	No	Yes	No	8	8
11	6x51	6x55	d4_off_allo	10.737	9.67576	Yes	Yes	No	No	8	7
12	7x38	7x42	d4_off_allo	16.7726	2.21576	No	No	Yes	Yes	6	8
13	3x40	5x50	d4_off_allo	11.5436	9.64582	No	No	No	No	9	9
14	6x51	7x38	d4_off_allo	16.4273	4.32886	Yes	Yes	No	No	8	6
15	2x50	7x46	Shared	98.3675	17.7218	No	No	No	No	9	9
16	1x50	2x50	Shared	97.9283	19.8991	Yes	Yes	No	No	9	9
17	1x50	7x50	Shared	97.0858	30.657	Yes	Yes	No	No	9	9
18	1x53	7x50	Shared	96.514	37.0092	No	No	No	No	9	9
19	1x53	7x53	Shared	96.3124	39.1094	No	No	Yes	Yes	9	9
20	7x53	8x50	Shared	54.5357	23.967	Yes	Yes	Yes	Yes	9	8
21	2x43	7x53	Shared	41.1358	21.439	No	No	Yes	Yes	8	9
22	2x40	2x43	Shared	40.6911	22.41	Yes	Yes	No	No	9	8
23	2x40	8x50	Shared	43.3263	39.6741	Yes	Yes	Yes	Yes	9	8
24	2x37	2x40	Shared	83.8987	72.7821	No	No	Yes	Yes	8	9
25	2x37	2x38	Shared	82.7275	73.4836	No	No	No	No	8	7
26	2x38	4x42	Shared	55.5494	73.073	No	No	Yes	Yes	7	8
27	2x42	4x42	Shared	39.8845	79.4294	Yes	Yes	Yes	Yes	8	8
28	2x42	3x46	Shared	26.3494	43.6393	Yes	Yes	No	No	8	9
29	2x42	4x46	Shared	11.9303	98.7681	Yes	Yes	No	No	8	8
30	3x36	Lig	Shared	11.2646	14.5949	No	No	Yes	Yes	8	0
31	3x36	6x48	Shared	10.6016	13.7565	No	No	Yes	Yes	8	9
32	6x44	6x48	Shared	22.9131	25.4213	Yes	Yes	Yes	Yes	9	9
33	6x51	Lig	Shared	23.275	32.6418	Yes	Yes	Yes	Yes	8	0
34	6x48	6x51	Shared	18.4935	16.1904	Yes	Yes	Yes	Yes	9	8
35	6x52	Lig	Shared	20.0762	31.8205	Yes	Yes	Yes	Yes	8	0
36	6x48	6x52	Shared	11.0933	14.7489	Yes	Yes	Yes	Yes	9	8
37	3x28	Lig	Shared	15.6815	14.796	No	No	Yes	Yes	7	0
38	E2x52	Lig	Shared	14.4937	13.4015	No	No	Yes	Yes	7	0
39	3x33	Lig	Shared	12.0159	11.5622	No	No	Yes	Yes	9	0
40	5x39	5x43	Shared	10.6237	13.209	Yes	Yes	No	No	8	9
41	3x40	6x44	Shared	14.4163	12.8454	No	No	Yes	Yes	9	9
42	3x46	5x58	Shared	24.9323	42.6427	No	No	Yes	Yes	9	9
43	3x47	5x58	Shared	14.803	37.531	No	No	Yes	Yes	9	9
44	3x47	5x57	Shared	13.397	35.4265	No	No	No	No	9	8
45	3x51	5x57	Shared	10.458	34.3614	Yes	Yes	No	No	8	8
46	5x65	6x31	Shared	12.0794	16.2247	Yes	No	Yes	Yes	8	7
47	4x41	4x42	Shared	13.6263	13.8207	No	No	Yes	Yes	8	8
48	6x48	7x45	Shared	11.4552	12.7085	Yes	Yes	No	No	9	9
49	6x51	7x37	Shared	10.9193	12.0968	Yes	Yes	No	No	8	7
50	7x42	Lig	Shared	74.797	12.5845	Yes	Yes	Yes	Yes	8	0
51	1x39	7x39	d4_off	8.54925	12.8069	No	No	No	No	7	8
52	2x60	7x39	d4_off	9.25916	13.9918	Yes	Yes	No	No	8	8
53	2x60	Lig	d4_off	4.41412	16.2503	Yes	Yes	Yes	Yes	8	0
54	5x461	Lig	d4_off	5.1406	86.098	No	No	Yes	Yes	8	0
55	3x37	5x461	d4_off	4.51356	92.9977	Yes	Yes	No	No	8	8
56	3x37	4x53	d4_off	0.944699	98.9092	Yes	Yes	No	No	8	8
57	3x38	4x53	d4_off	0	100	No	No	No	No	8	8
58	3x38	4x50	d4_off	1.5082	99.876	No	No	Yes	Yes	8	9
59	2x45	4x50	d4_off	4.49699	98.1393	No	No	Yes	Yes	9	9
60	2x45	4x46	d4_off	8.98017	99.1274	No	No	No	No	9	8
61	1x46	7x46	d4_off	8.26197	15.536	Yes	Yes	No	No	8	9
62	2x40	I1x50	d4_off	1.07453	10.219	Yes	Yes	Yes	Yes	9	8
63	3x29	E2x52	d4_off	9.02713	10.0137	Yes	Yes	No	No	7	7
64	3x51	5x61	d4_off	1.5082	28.9075	Yes	Yes	No	No	8	9
65	3x54	5x61	d4_off	0	27.7825	No	No	No	No	8	9
66	3x54	5x65	d4_off	3.06337	23.2141	No	No	Yes	No	8	8
67	5x47	6x52	d4_off	6.88636	15.5231	Yes	Yes	Yes	Yes	9	8
68	8x47	8x50	d4_off	9.32545	17.5764	No	No	Yes	Yes	9	8

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
2x53	2x57	Shared	5.54	6.92	1	0	2	2
2x53	7x42	d4_off	4.69	0	1	0	2	1
2x57	7x42	Shared	8.21	8.21	1	0	2	1
2x59	3x28	Shared	8.3	5.54	0	0	2	1
2x60	2x64	Shared	10.49	12.83	1	1	1	2
2x60	7x38	d4_off	3.89	0	1	1	1	2
2x60	7x39	Shared	13.03	14.03	1	1	1	2
2x60	7x42	Shared	11.35	11.35	1	1	1	1
2x60	Lig	Shared	8.97	6.72	1	1	1	0
2x64	7x39	Shared	9.81	8.72	1	1	2	2
3x28	E1x50	Shared	3.42	4.56	0	0	1	2
3x28	Lig	Shared	6.79	5.94	0	0	1	0
3x29	E2x52	Shared	5.65	5.65	0	0	2	1
3x32	7x42	Shared	8.05	8.05	1	1	1	1
3x32	Lig	Shared	19.98	23.31	1	1	1	0
3x33	4x57	Shared	3.39	3.39	0	0	1	2
3x33	5x39	Shared	3.79	6.31	0	0	1	2
3x33	Lig	Shared	11.88	10.97	0	0	1	0
3x36	6x48	Shared	7.84	7.84	0	0	1	2
3x36	Lig	Shared	4.87	4.87	0	0	1	0
3x37	5x461	Shared	9.59	9.59	1	1	2	1
E2x52	Lig	Shared	5.94	6.79	0	0	1	0
5x39	5x43	Shared	5.09	5.09	1	0	2	1
5x43	5x461	Shared	4.89	4.89	1	1	1	1
5x43	Lig	Shared	6.45	6.45	1	1	1	0
5x44	6x52	Shared	3.96	3.96	0	0	2	1
5x461	Lig	Shared	3.68	3.68	1	1	1	0
5x47	6x52	Shared	25.72	24.65	0	0	2	1
6x48	6x51	Shared	11.02	12.03	1	1	2	1
6x48	6x52	Shared	6.01	6.01	1	1	2	1
6x51	6x52	Shared	9.65	9.65	1	1	1	1
6x51	6x55	Shared	22.63	18.1	1	1	1	2
6x51	7x37	Shared	3.93	3.93	1	1	1	2
6x51	7x38	Shared	3.89	6.49	1	1	1	2
6x51	Lig	Shared	14.2	14.2	1	1	1	0
6x52	Lig	Shared	6.72	7.47	1	1	1	0
7x38	7x42	Shared	4.99	4.99	1	0	2	1
7x42	Lig	Shared	5.75	5.75	1	1	1	0
5x40	E2x52	Shared	2.98	2.98	0	0	2	1
2x63	E1.G99	Shared	1.86	1.86	0	0	1	2
2x63	Lig	Shared	1.84	1.84	0	0	1	0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	d4_off_allo	5WIV-D₄-Nemonapride-Na
	d4_off	5WIU-D₄-Nemonapride

Network Difference
Value	d4_off_allo	d4_off
I_min	3.53	3.28
Number of Linked Nodes	254	244
Number of Specific Nodes	13 (5.12%)	3 (1.23%)
Number of Shared Nodes	241 (94.88%)	241 (98.77%)
Number of Links	283	271
Number of Specific Links	41 (14.49%)	29 (10.70%)
Number of Shared Links	242 (85.51%)	242 (89.30%)
Number of Hubs	34	29
Number of Specific Hubs	7 (20.59%)	2 (6.90%)
Number of Shared Hubs	27 (79.41%)	27 (93.10%)
Average % Shared Neighbours (Jaccard)	76.75
Average % Shared Neighbours (Otsuka)	82.16
Average % Shared Neighbours (Overlap Coefficient)	88.39
Average % Shared Cliques (k3-6)	88.33
Graphlets Similarity	0.673943

Paths Difference
Value	d4_off_allo	d4_off
Number Of Nodes in MetaPath	46	53
Specific Nodes in MetaPath	9 (19.57%)	16 (30.19%)
Shared Nodes in MetaPath	241 (94.88%)	241 (94.88%)
Number Of Links MetaPath	50	54
Specific Links in MetaPath	14 (28.00%)	18 (33.33%)
Shared Links in MetaPath	242 (85.51%)	242 (85.51%)
Number of Shortest Paths	56586	44267
Length Of Smallest Path	3	3
Average Path Length	16.3166	15.2906
Length of Longest Path	31	33
Minimum Path Strength	1.19	1.285
Average Path Strength	6.94384	6.61175
Maximum Path Strength	18.5367	19.3333
Minimum Path Correlation	0.7	0.7
Average Path Correlation	0.93031	0.928287
Maximum Path Correlation	0.99	0.99
Minimum % Of Corr. Nodes	4	3.44828
Average % Of Corr. Nodes	47.378	49.5405
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	39.4057	38.7283
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

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