psnGPCR

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Orange: nodes, hubs and links specific of dop_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of dop_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	dop_off Int. Strength	dop_on Int. Strength	dop_off Hub1?	dop_on Hub1?	dop_off Hub2?	dop_on Hub2?	ConSurf1	ConSurf2
1	3x32	Lig	dop_off	16.81	0	No	No	Yes	Yes	6	0
2	6x48	Lig	dop_off	7.06	0	Yes	Yes	Yes	Yes	8	0
3	6x51	Lig	dop_off	4.91	0	No	No	Yes	Yes	6	0
4	7x42	Lig	dop_off	8.88	0	Yes	No	Yes	Yes	7	0
5	1x35	1x39	dop_off	4.84	0	No	No	Yes	No	5	8
6	1x42	7x47	dop_off	8.08	0	No	No	No	No	7	7
7	1x49	7x50	dop_off	4.06	0	No	No	No	No	8	9
8	1x50	2x47	dop_off	4.69	0	No	No	No	No	9	9
9	1x50	2x50	dop_off	5.39	0	No	No	Yes	No	9	9
10	1x50	7x50	dop_off	9.77	0	No	No	No	No	9	9
11	1x53	7x53	dop_off	5.05	0	No	Yes	Yes	No	8	9
12	1x55	1x56	dop_off	4.52	0	No	No	No	No	3	7
13	1x57	2x40	dop_off	4.25	0	No	No	No	No	7	8
14	1x60	I1x50	dop_off	4.69	0	No	No	No	No	5	6
15	I1x48	I1x51	dop_off	6.01	0	No	No	No	No	5	7
16	2x40	8x50	dop_off	7.25	0	No	No	No	Yes	8	8
17	2x42	3x46	dop_off	8.38	0	Yes	Yes	No	No	7	8
18	2x43	7x53	dop_off	9.67	0	No	Yes	Yes	No	8	9
19	2x45	4x49	dop_off	4.25	0	Yes	No	No	No	9	7
20	2x46	3x43	dop_off	4.15	0	No	No	Yes	No	9	8
21	2x50	3x35	dop_off	5.39	0	Yes	No	No	No	9	7
22	2x50	7x46	dop_off	10.31	0	Yes	No	No	No	9	8
23	2x50	7x49	dop_off	6.73	0	Yes	No	No	Yes	9	9
24	2x56	3x28	dop_off	9.52	0	No	No	No	No	5	5
25	2x60	2x63	dop_off	8.14	0	No	No	No	No	6	5
26	2x66	E1x49	dop_off	4.52	0	No	No	No	No	4	5
27	3x34	4x57	dop_off	7.24	0	Yes	Yes	No	No	4	6
28	3x35	3x39	dop_off	5.96	0	No	No	No	No	7	9
29	3x36	6x52	dop_off	6.57	0	No	No	No	Yes	6	7
30	3x37	5x43	dop_off	5.24	0	Yes	No	No	No	6	5
31	3x37	5x461	dop_off	4.16	0	Yes	No	No	No	6	4
32	3x40	6x44	dop_off	8.79	0	No	No	Yes	No	7	9
33	3x41	4x49	dop_off	7.54	0	No	No	No	No	4	7
34	3x41	4x52	dop_off	7.31	0	No	No	No	No	4	3
35	3x42	4x49	dop_off	6.08	0	No	No	No	No	7	7
36	3x43	6x41	dop_off	7.45	0	Yes	No	No	No	8	7
37	3x43	6x44	dop_off	4.87	0	Yes	No	Yes	No	8	9
38	3x44	5x54	dop_off	6.08	0	No	No	No	No	7	8
39	3x46	6x37	dop_off	6.09	0	No	No	No	No	8	7
40	3x49	4x41	dop_off	6.91	0	Yes	No	No	No	8	5
41	3x50	6x33	dop_off	12.53	0	No	No	No	No	9	7
42	3x50	6x34	dop_off	11.64	0	No	No	Yes	No	9	7
43	3x54	6x31	dop_off	7.85	0	No	No	No	No	8	5
44	4x41	I2x56	dop_off	4.96	0	No	No	No	No	5	4
45	4x41	4x45	dop_off	5.82	0	No	No	No	No	5	5
46	5x31	5x34	dop_off	4.17	0	No	No	No	No	2	1
47	5x34	5x35	dop_off	12.54	0	No	No	No	No	1	3
48	5x42	5x46	dop_off	4.19	0	No	No	No	No	3	4
49	5x54	6x41	dop_off	4.61	0	No	No	No	No	8	7
50	5x58	6x38	dop_off	10.55	0	Yes	Yes	No	No	9	4
51	5x61	6x34	dop_off	4.52	0	Yes	No	Yes	No	8	7
52	5x67	6x25	dop_off	14.37	0	No	No	No	No	5	4
53	6x30	6x35	dop_off	4.86	0	Yes	No	No	No	7	7
54	6x31	6x34	dop_off	9.06	0	No	No	Yes	No	5	7
55	6x32	6x33	dop_off	7.52	0	No	No	No	No	7	7
56	6x32	8x47	dop_off	7.15	0	No	No	Yes	No	7	8
57	6x32	8x48	dop_off	11.63	0	No	No	No	No	7	6
58	6x36	7x53	dop_off	4.79	0	No	No	Yes	No	8	9
59	6x36	7x56	dop_off	7.07	0	No	No	No	No	8	6
60	6x36	8x47	dop_off	5.54	0	No	No	Yes	No	8	8
61	6x39	7x56	dop_off	4.47	0	No	No	No	No	6	6
62	6x44	7x45	dop_off	4.83	0	Yes	No	Yes	No	9	9
63	6x47	7x40	dop_off	4.76	0	No	No	No	No	7	7
64	6x48	7x41	dop_off	4.22	0	Yes	Yes	No	No	8	7
65	6x51	7x38	dop_off	4.42	0	No	No	No	No	6	5
66	7x31	E3	dop_off	13.08	0	No	No	No	Yes	4	1
67	8x47	8x50	dop_off	10.75	0	Yes	No	No	Yes	8	8
68	8x48	8x52	dop_off	4.65	0	No	No	No	No	6	5
69	2x39	3x50	dop_off	3.88	0	No	No	No	No	8	9
70	1x39	2x61	dop_off	3.82	0	Yes	No	No	No	8	7
71	3x30	3x34	dop_off	3.82	0	No	No	Yes	Yes	6	4
72	6x41	6x42	dop_off	3.68	0	No	No	No	No	7	4
73	8x50	I1x50	dop_off	3.65	0	No	Yes	No	No	8	6
74	1x46	2x54	dop_off	3.64	0	No	No	No	No	8	6
75	3x51	5x61	dop_off	3.59	0	Yes	Yes	Yes	No	8	8
76	2x63	2x64	dop_off	3.58	0	No	No	No	Yes	5	5
77	5x66	6x27	dop_off	3.57	0	No	No	No	No	5	4
78	1x39	2x57	dop_off	3.52	0	Yes	No	Yes	No	8	7
79	3x33	E2x52	dop_off	3.52	0	No	No	No	No	4	4
80	4x38	4x40	dop_off	3.36	0	No	No	No	No	6	5
81	4x54	4x58	dop_off	3.23	0	No	No	No	No	4	3
82	5x67	5x68	dop_off	3.23	0	No	No	No	No	5	6
83	3x29	4x64	dop_off	3.15	0	No	No	No	No	5	6
84	2x38	3x49	dop_off	3.09	0	No	No	Yes	No	6	8
85	5x37	5x41	dop_off	3.04	0	No	No	No	No	4	5
86	1x25	1x29	dop_off	3	0	No	No	No	No	6	4
87	2x54	2x57	dop_off	2.95	0	No	No	Yes	No	6	7
88	5x65	6x30	dop_off	2.77	0	No	No	Yes	No	8	7
89	1x60	8x53	dop_off	2.69	0	No	No	No	No	5	6
90	6x25	6x27	dop_off	2.6	0	No	No	No	No	4	4
91	5x44	6x53	dop_off	2.51	0	Yes	Yes	No	No	5	6
92	5x47	6x53	dop_off	2.51	0	Yes	Yes	No	No	7	6
93	3x28	E1x50	dop_off	2.45	0	No	No	Yes	Yes	5	8
94	7x55	7x56	dop_off	2.44	0	No	No	No	No	6	6
95	7x27	E3	dop_off	2.38	0	Yes	No	No	Yes	3	1
96	1x38	1x39	dop_off	2.34	0	No	No	Yes	No	5	8
97	6x49	6x50	dop_off	1.87	0	No	No	No	No	5	9
98	1x45	1x46	dop_off	1.84	0	No	No	No	No	6	8
99	I2x50	I2x51	dop_off	1.77	0	No	No	No	No	8	5
100	1x49	1x52	dop_off	1.71	0	No	No	No	No	8	6
101	5x59	5x62	dop_off	1.71	0	No	No	No	No	3	5
102	7x43	7x47	dop_off	1.71	0	No	No	No	No	5	7
103	1x51	2x51	dop_off	1.7	0	No	No	No	No	3	8
104	1x27	1x28	dop_off	1.63	0	No	No	No	No	3	6
105	3x52	I2x53	dop_off	1.62	0	No	No	No	No	5	5
106	1x32	2x65	dop_off	1.58	0	No	No	No	No	5	4
107	1x47	2x51	dop_off	1.58	0	No	No	No	No	6	8
108	6x43	7x48	dop_off	1.58	0	No	No	No	No	6	6
109	6x43	7x52	dop_off	1.58	0	No	No	No	No	6	8
110	6x43	7x45	dop_off	1.56	0	No	No	Yes	No	6	9
111	4x61	4x62	dop_off	1.52	0	No	No	No	No	5	5
112	5x51	5x55	dop_off	1.52	0	No	No	No	No	7	5
113	I1x48	I1x49	dop_off	1.5	0	No	No	No	No	5	5
114	2x46	6x40	dop_off	1.49	0	No	No	No	No	9	7
115	6x40	7x52	dop_off	1.49	0	No	No	No	No	7	8
116	5x37	6x60	dop_off	1.47	0	No	No	No	No	4	4
117	1x28	2x67	dop_off	1.44	0	No	No	No	No	6	4
118	1x33	2x65	dop_off	1.43	0	No	No	No	No	5	4
119	3x55	5x64	dop_off	1.39	0	No	No	No	No	6	5
120	7x54	7x55	dop_off	1.39	0	No	No	No	No	6	6
121	5x62	5x65	dop_off	1.38	0	No	No	No	No	5	8
122	5x62	6x30	dop_off	1.38	0	No	No	Yes	No	5	7
123	I2x54	I2x55	dop_off	1.36	0	No	No	No	No	5	4
124	5x65	5x66	dop_off	1.21	0	No	No	No	No	8	5
125	3x33	Lig	Shared	12.1	13.68	No	No	Yes	Yes	4	0
126	3x36	Lig	Shared	13.62	8.38	No	No	Yes	Yes	6	0
127	5x40	Lig	Shared	5.82	12.16	No	Yes	Yes	Yes	5	0
128	5x43	Lig	Shared	4.1	5.05	No	No	Yes	Yes	5	0
129	6x55	Lig	Shared	17.43	4.04	No	No	Yes	Yes	6	0
130	7x38	Lig	Shared	6.88	10.25	No	No	Yes	Yes	5	0
131	1x36	2x61	Shared	9.59	4.8	No	Yes	No	No	6	7
132	1x36	2x65	Shared	7.37	10.32	No	Yes	No	No	6	4
133	1x47	2x54	Shared	5.9	7.37	No	No	No	No	6	6
134	1x54	2x44	Shared	7.46	8.71	No	No	No	Yes	7	5
135	1x54	2x48	Shared	5.65	2.83	No	No	No	No	7	6
136	1x59	1x60	Shared	8.23	6.17	No	No	No	No	4	5
137	2x37	2x40	Shared	4.39	7.31	No	No	No	No	7	8
138	2x41	4x46	Shared	4.25	2.83	No	Yes	No	No	5	7
139	2x42	3x49	Shared	11.49	9.2	Yes	Yes	Yes	No	7	8
140	2x42	4x42	Shared	5.34	4	Yes	Yes	No	No	7	7
141	2x42	4x45	Shared	9.67	2.42	Yes	Yes	No	No	7	5
142	2x42	4x46	Shared	4.65	9.3	Yes	Yes	No	No	7	7
143	2x45	3x42	Shared	5.85	4.8	Yes	No	No	No	9	7
144	2x45	4x46	Shared	20.43	7.45	Yes	No	No	No	9	7
145	2x45	4x50	Shared	7.91	6.18	Yes	No	Yes	Yes	9	9
146	2x46	3x42	Shared	4.42	4.42	No	No	No	No	9	7
147	2x48	4x50	Shared	5.69	5.69	No	No	Yes	Yes	6	9
148	2x53	3x35	Shared	6.25	3.42	No	No	No	No	6	7
149	2x56	3x31	Shared	4.56	3.04	No	No	No	No	5	5
150	2x57	7x42	Shared	4.69	15.24	Yes	No	Yes	No	7	7
151	2x59	E1x52	Shared	10.72	9.65	No	No	Yes	Yes	6	6
152	2x59	3x24	Shared	8.53	3.65	No	No	No	No	6	5
153	2x60	7x42	Shared	11.27	11.27	No	No	Yes	No	6	7
154	2x63	E1x50	Shared	4.64	4.64	No	No	Yes	Yes	5	8
155	2x64	7x35	Shared	11.98	8.71	No	Yes	No	No	5	4
156	E1x49	E2	Shared	6.53	4.85	No	No	Yes	Yes	5	4
157	E1x50	E1x52	Shared	9.02	17.04	Yes	Yes	Yes	Yes	8	6
158	E1x50	E2x50	Shared	7.84	6.53	Yes	Yes	No	Yes	8	9
159	E1x51	E1x52	Shared	10.11	5.78	No	No	Yes	Yes	3	6
160	3x22	E2	Shared	16.99	8.49	No	No	Yes	Yes	4	4
161	3x25	E2x50	Shared	7.28	7.28	No	No	No	Yes	9	9
162	3x26	4x64	Shared	4.82	3.21	No	No	No	No	7	6
163	3x30	4x61	Shared	10.73	6.13	No	No	No	No	6	5
164	3x32	7x42	Shared	8.05	9.2	No	No	Yes	No	6	7
165	3x33	4x60	Shared	9.67	12.09	No	No	No	No	4	4
166	3x34	4x50	Shared	5.79	9.65	Yes	Yes	Yes	Yes	4	9
167	3x34	4x54	Shared	7.63	6.36	Yes	Yes	No	No	4	4
168	3x36	6x48	Shared	8.14	5.82	No	No	Yes	Yes	6	8
169	3x37	3x41	Shared	4.29	3.22	Yes	No	No	No	6	4
170	3x37	4x56	Shared	6.55	6.55	Yes	No	No	No	6	4
171	3x38	4x50	Shared	15.77	12.13	No	No	Yes	Yes	7	9
172	3x40	5x50	Shared	6.77	3.39	No	No	No	No	7	9
173	3x45	4x45	Shared	8.75	4.37	No	No	No	No	6	5
174	3x47	5x54	Shared	12.39	11.46	No	No	No	No	9	8
175	3x47	5x58	Shared	5.09	10.75	No	No	Yes	Yes	9	9
176	3x49	I2x57	Shared	16.68	11.91	Yes	No	No	No	8	7
177	3x51	3x55	Shared	13.44	8.06	Yes	Yes	No	No	8	6
178	3x51	3x56	Shared	4.36	6.53	Yes	Yes	No	No	8	5
179	3x51	5x57	Shared	5.38	9.41	Yes	Yes	No	No	8	6
180	3x51	5x60	Shared	7.03	7.03	Yes	Yes	No	No	8	5
181	3x52	I2x56	Shared	7.54	12.56	No	No	No	No	5	4
182	3x53	I2x57	Shared	6.91	5.53	No	No	No	No	8	7
183	3x54	5x61	Shared	4.56	7.61	No	No	Yes	No	8	8
184	4x38	4x39	Shared	5.25	1.75	No	No	No	No	6	3
185	E2	E2	Shared	36.45	33.94	Yes	Yes	Yes	Yes	4	4
186	E2	E2x51	Shared	5.92	5.24	Yes	Yes	No	No	4	4
187	5x35	E2	Shared	4.01	9.77	No	No	Yes	Yes	3	4
188	5x36	E2	Shared	9.55	14.33	No	No	Yes	Yes	5	4
189	5x39	E2	Shared	6.49	9.08	No	No	Yes	Yes	5	4
190	5x31	5x33	Shared	4.05	4.05	No	No	No	No	2	3
191	5x36	5x40	Shared	9.68	8.3	No	No	No	Yes	5	5
192	5x40	6x59	Shared	4.5	9.01	No	Yes	No	No	5	4
193	5x44	5x47	Shared	4.29	9.65	Yes	Yes	Yes	Yes	5	7
194	5x44	6x56	Shared	12.56	5.02	Yes	Yes	No	No	5	6
195	5x47	5x51	Shared	7.54	7.54	Yes	Yes	No	No	7	7
196	5x47	6x52	Shared	13.58	3.39	Yes	Yes	No	Yes	7	7
197	5x58	5x61	Shared	5.99	2.39	Yes	Yes	Yes	No	9	8
198	5x58	6x37	Shared	7.57	8.83	Yes	Yes	No	No	9	7
199	5x60	5x63	Shared	4.15	1.38	No	No	No	No	5	4
200	6x44	6x48	Shared	25.05	11.02	Yes	No	Yes	Yes	9	8
201	6x47	7x45	Shared	9.45	9.45	No	No	Yes	No	7	9
202	6x48	6x52	Shared	4.23	4.23	Yes	Yes	No	Yes	8	7
203	6x48	7x45	Shared	6.78	7.91	Yes	Yes	Yes	No	8	9
204	6x50	7x37	Shared	5.65	1.88	No	No	No	No	9	6
205	6x54	7x34	Shared	8.53	9.74	No	No	No	No	5	4
206	6x57	6x61	Shared	6.41	1.6	No	No	No	No	5	3
207	6x58	E3	Shared	20.04	5	No	No	No	Yes	4	1
208	7x27	7x29	Shared	6.79	2.71	Yes	No	No	No	3	1
209	7x27	7x30	Shared	4.38	5.84	Yes	No	No	No	3	4
210	7x49	7x53	Shared	8.14	4.65	No	Yes	Yes	No	9	9
211	8x47	8x49	Shared	6.73	9.42	Yes	No	No	No	8	7
212	5x44	5x48	Shared	3.93	2.62	Yes	Yes	No	No	5	4
213	6x58	Lig	Shared	3.92	6.13	No	No	Yes	Yes	4	0
214	5x34	5x38	Shared	3.79	6.31	No	No	No	No	1	4
215	1x43	2x58	Shared	3.77	3.77	No	No	No	No	6	9
216	4x63	E2	Shared	3.73	3.73	No	No	Yes	Yes	4	4
217	5x45	5x46	Shared	3.65	2.44	No	No	No	No	5	4
218	4x58	4x59	Shared	3.53	3.53	No	No	No	No	3	7
219	5x49	5x50	Shared	3.53	3.53	No	No	No	No	6	9
220	3x48	5x57	Shared	3.42	1.71	No	No	No	No	6	6
221	2x49	3x38	Shared	3.36	3.36	No	No	No	No	8	7
222	1x55	1x59	Shared	3.21	8.55	No	No	No	No	3	4
223	1x43	2x57	Shared	3.17	6.35	No	No	Yes	No	6	7
224	3x29	E2x50	Shared	3.17	3.17	No	No	No	Yes	5	9
225	5x49	5x53	Shared	3.07	3.07	No	No	No	No	6	5
226	5x51	6x45	Shared	3.07	3.07	No	No	No	No	7	5
227	1x42	2x57	Shared	2.98	1.49	No	No	Yes	No	7	7
228	5x45	5x48	Shared	2.98	4.47	No	No	No	No	5	4
229	2x52	3x31	Shared	2.85	2.85	No	No	No	No	6	5
230	7x34	7x38	Shared	2.85	4.28	No	No	No	No	4	5
231	3x21	E1x50	Shared	2.81	2.81	No	No	Yes	Yes	7	8
232	2x62	E1x52	Shared	2.77	2.77	No	No	Yes	Yes	4	6
233	5x47	6x49	Shared	2.77	2.77	Yes	Yes	No	No	7	5
234	3x34	4x53	Shared	2.67	4	Yes	Yes	No	No	4	8
235	2x41	4x39	Shared	1.69	1.69	No	Yes	No	No	5	3
236	7x27	7x28	Shared	1.61	6.44	Yes	No	No	No	3	3
237	1x36	1x40	Shared	1.6	1.6	No	Yes	No	No	6	5
238	2x55	2x56	Shared	1.6	1.6	No	No	No	No	4	5
239	1x38	7x39	Shared	1.58	3.15	No	No	No	No	5	4
240	3x24	3x27	Shared	1.58	1.58	No	No	No	No	5	5
241	5x37	6x59	Shared	1.57	3.14	No	No	No	No	4	4
242	6x53	6x57	Shared	1.54	1.54	No	No	No	No	6	5
243	3x56	I2x50	Shared	1.53	1.53	No	No	No	No	5	8
244	3x43	6x40	Shared	1.49	2.98	Yes	No	No	No	8	7
245	5x52	5x56	Shared	1.49	1.49	No	No	No	No	3	5
246	6x30	6x34	Shared	1.47	2.95	Yes	No	Yes	No	7	7
247	2x41	4x43	Shared	1.45	4.36	No	Yes	No	No	5	3
248	5x32	E2	Shared	1.32	2.64	No	No	Yes	Yes	1	4
249	1x58	2x44	Shared	1.31	3.93	No	No	No	Yes	2	5
250	3x56	I2x52	Shared	1.31	2.62	No	No	No	No	5	5
251	1x31	1x35	dop_on	0	4.28	No	No	No	No	4	5
252	1x31	7x32	dop_on	0	4.73	No	No	No	No	4	1
253	1x35	2x64	dop_on	0	12.09	No	No	No	Yes	5	5
254	1x39	7x35	dop_on	0	13.07	Yes	No	No	No	8	4
255	1x39	7x38	dop_on	0	6.04	Yes	No	No	No	8	5
256	1x42	7x43	dop_on	0	4.61	No	No	No	No	7	5
257	1x43	1x47	dop_on	0	3.17	No	No	No	No	6	6
258	1x45	7x48	dop_on	0	2.98	No	No	No	No	6	6
259	1x46	7x47	dop_on	0	3.71	No	No	No	No	8	7
260	1x49	7x51	dop_on	0	3.68	No	No	No	No	8	6
261	1x50	2x51	dop_on	0	4.69	No	No	No	No	9	8
262	1x50	7x47	dop_on	0	2.98	No	No	No	No	9	7
263	1x50	7x51	dop_on	0	2.96	No	No	No	No	9	6
264	1x53	1x57	dop_on	0	3.07	No	Yes	No	No	8	7
265	1x53	7x51	dop_on	0	4.81	No	Yes	No	No	8	6
266	1x53	7x54	dop_on	0	3.39	No	Yes	No	No	8	6
267	1x56	8x50	dop_on	0	6.55	No	No	No	Yes	7	8
268	1x57	2x43	dop_on	0	2.94	No	No	No	Yes	7	8
269	1x57	2x44	dop_on	0	5.02	No	No	No	Yes	7	5
270	2x40	I1x48	dop_on	0	4.39	No	No	No	No	8	5
271	2x41	I1x50	dop_on	0	2.92	No	Yes	No	No	5	6
272	2x44	I1x50	dop_on	0	8.71	No	Yes	No	No	5	6
273	2x37	2x39	dop_on	0	3.14	No	No	No	No	7	8
274	2x43	3x46	dop_on	0	4.37	No	Yes	No	No	8	8
275	2x46	3x39	dop_on	0	3	No	No	No	No	9	9
276	2x46	7x50	dop_on	0	6.57	No	No	No	No	9	9
277	2x49	3x39	dop_on	0	3.42	No	No	No	No	8	9
278	2x52	3x35	dop_on	0	4.5	No	No	No	No	6	7
279	2x54	7x47	dop_on	0	7.99	No	No	No	No	6	7
280	2x56	2x60	dop_on	0	5.67	No	No	No	No	5	6
281	2x59	3x28	dop_on	0	3.93	No	No	No	No	6	5
282	2x60	Lig	dop_on	0	10.54	No	No	Yes	Yes	6	0
283	2x63	Lig	dop_on	0	15.2	No	No	Yes	Yes	5	0
284	2x66	E1x51	dop_on	0	3.35	No	No	No	No	4	3
285	3x25	E1x50	dop_on	0	3.92	No	No	Yes	Yes	9	8
286	E1x50	Lig	dop_on	0	5.01	Yes	Yes	Yes	Yes	8	0
287	3x24	E1x52	dop_on	0	6.09	No	No	Yes	Yes	5	6
288	3x22	3x26	dop_on	0	5.4	No	No	No	No	4	7
289	3x25	E2	dop_on	0	3.38	No	No	Yes	Yes	9	4
290	3x29	Lig	dop_on	0	4.87	No	No	Yes	Yes	5	0
291	3x34	3x38	dop_on	0	7.49	Yes	Yes	No	No	4	7
292	3x36	3x37	dop_on	0	3.73	No	No	Yes	No	6	6
293	3x40	6x48	dop_on	0	3.52	No	No	Yes	Yes	7	8
294	3x43	7x53	dop_on	0	4.69	Yes	No	Yes	No	8	9
295	3x44	5x50	dop_on	0	3.5	No	No	No	No	7	9
296	3x44	5x53	dop_on	0	4.56	No	No	No	No	7	5
297	3x45	4x49	dop_on	0	2.92	No	No	No	No	6	7
298	3x46	3x50	dop_on	0	3.72	No	No	No	No	8	9
299	3x48	3x52	dop_on	0	3.07	No	No	No	No	6	5
300	3x50	5x58	dop_on	0	8.23	No	No	Yes	Yes	9	9
301	4x38	4x41	dop_on	0	6.01	No	No	No	No	6	5
302	4x60	E2x52	dop_on	0	4.28	No	No	No	No	4	4
303	E2	E3	dop_on	0	11.73	Yes	Yes	No	Yes	4	1
304	E2	Lig	dop_on	0	3.68	Yes	Yes	Yes	Yes	4	0
305	E2x50	Lig	dop_on	0	5.59	No	Yes	Yes	Yes	9	0
306	E2	E2x52	dop_on	0	3.65	Yes	Yes	No	No	4	4
307	E2x52	Lig	dop_on	0	5.3	No	No	Yes	Yes	4	0
308	5x31	E2	dop_on	0	7.13	No	No	Yes	Yes	2	4
309	5x33	5x34	dop_on	0	7.72	No	No	No	No	3	1
310	5x36	6x59	dop_on	0	2.89	No	No	No	No	5	4
311	5x40	6x55	dop_on	0	4.55	No	Yes	No	No	5	6
312	5x41	6x56	dop_on	0	2.94	No	No	No	No	5	6
313	5x44	6x52	dop_on	0	5.66	Yes	Yes	No	Yes	5	7
314	5x51	6x44	dop_on	0	5.02	No	No	Yes	No	7	9
315	5x54	5x58	dop_on	0	3.63	No	No	Yes	Yes	8	9
316	5x61	5x65	dop_on	0	4.24	Yes	No	No	No	8	8
317	5x62	6x34	dop_on	0	5.9	No	No	Yes	No	5	7
318	5x63	5x66	dop_on	0	3.64	No	No	No	No	4	5
319	5x65	I3	dop_on	0	5.54	No	No	No	Yes	8	4
320	5x68	I3	dop_on	0	7.45	No	No	No	Yes	6	4
321	6x29	I3	dop_on	0	3	No	No	No	Yes	5	4
322	6x30	I3	dop_on	0	9.69	Yes	No	No	Yes	7	4
323	6x33	I3	dop_on	0	2.85	No	No	No	Yes	7	4
324	I3	I3	dop_on	0	3.71	No	Yes	No	Yes	4	4
325	6x23	6x26	dop_on	0	7.65	No	No	No	No	0	4
326	6x25	6x28	dop_on	0	9.3	No	No	No	No	4	4
327	6x31	6x35	dop_on	0	15.99	No	No	No	No	5	7
328	6x32	6x36	dop_on	0	4.96	No	No	No	No	7	8
329	6x34	6x38	dop_on	0	2.95	Yes	No	No	No	7	4
330	6x40	7x53	dop_on	0	11.36	No	No	Yes	No	7	9
331	6x43	7x49	dop_on	0	3.13	No	No	No	Yes	6	9
332	6x51	6x55	dop_on	0	3.07	No	No	No	No	6	6
333	6x51	7x37	dop_on	0	3.27	No	No	No	No	6	6
334	6x52	Lig	dop_on	0	3.27	No	Yes	Yes	Yes	7	0
335	6x61	E3	dop_on	0	6.14	No	No	No	Yes	3	1
336	E3	E3	dop_on	0	16.67	No	Yes	No	Yes	1	1
337	7x34	Lig	dop_on	0	5.96	No	No	Yes	Yes	4	0
338	7x43	7x48	dop_on	0	7.14	No	No	No	No	5	6
339	7x45	7x49	dop_on	0	10.9	Yes	No	No	Yes	9	9
340	7x49	7x52	dop_on	0	4.12	No	Yes	No	No	9	8
341	7x55	8x50	dop_on	0	5.36	No	No	No	Yes	6	8
342	8x49	8x52	dop_on	0	6.03	No	No	No	No	7	5
343	8x50	8x54	dop_on	0	9.65	No	Yes	No	No	8	0
344	Lig	Lig	dop_on	0	56.35	Yes	Yes	Yes	Yes	0	0
345	I2x53	I2x57	dop_on	0	2.77	No	No	No	No	5	7
346	7x31	7x35	dop_on	0	2.77	No	No	No	No	4	4
347	7x52	7x56	dop_on	0	2.77	No	No	No	No	8	6
348	7x54	8x50	dop_on	0	2.77	No	No	No	Yes	6	8
349	8x48	8x51	dop_on	0	2.7	No	No	No	No	6	8
350	1x32	2x64	dop_on	0	2.67	No	No	No	Yes	5	5
351	5x64	5x67	dop_on	0	2.64	No	No	No	No	5	5
352	3x54	5x64	dop_on	0	2.62	No	No	No	No	8	5
353	5x47	5x48	dop_on	0	2.62	Yes	Yes	No	No	7	4
354	6x54	7x30	dop_on	0	2.62	No	No	No	No	5	4
355	1x56	1x60	dop_on	0	2.52	No	No	No	No	7	5
356	5x58	6x41	dop_on	0	2.52	Yes	Yes	No	No	9	7
357	4x45	I2x56	dop_on	0	2.51	No	No	No	No	5	4
358	1x36	2x64	dop_on	0	2.5	No	Yes	No	Yes	6	5
359	6x48	7x46	dop_on	0	2.47	Yes	Yes	No	No	8	8
360	2x50	2x53	dop_on	0	1.95	Yes	No	No	No	9	6
361	3x30	4x57	dop_on	0	1.86	No	No	No	No	6	6
362	4x56	4x57	dop_on	0	1.84	No	No	No	No	4	6
363	2x38	4x42	dop_on	0	1.79	No	No	No	No	6	7
364	1x48	1x49	dop_on	0	1.71	No	No	No	No	5	8
365	5x38	5x42	dop_on	0	1.71	No	No	No	No	4	3
366	1x53	2x47	dop_on	0	1.7	No	Yes	No	No	8	9
367	4x59	4x63	dop_on	0	1.68	No	No	No	No	7	4
368	3x40	5x461	dop_on	0	1.62	No	No	No	No	7	4
369	4x58	4x62	dop_on	0	1.6	No	No	No	No	3	5
370	6x42	6x46	dop_on	0	1.6	No	No	No	No	4	6
371	5x55	6x41	dop_on	0	1.59	No	No	No	No	5	7
372	4x47	4x51	dop_on	0	1.54	No	No	No	No	3	4
373	2x39	2x43	dop_on	0	1.52	No	No	No	Yes	8	8
374	1x28	1x29	dop_on	0	1.5	No	No	No	No	6	4
375	1x38	1x42	dop_on	0	1.49	No	No	No	No	5	7
376	5x56	5x60	dop_on	0	1.49	No	No	No	No	5	5
377	6x56	6x60	dop_on	0	1.43	No	No	No	No	6	4
378	7x40	7x43	dop_on	0	1.43	No	No	No	No	7	5
379	2x43	8x47	dop_on	0	1.4	No	Yes	Yes	No	8	8
380	1x38	7x36	dop_on	0	1.38	No	No	No	No	5	5
381	6x36	8x48	dop_on	0	1.35	No	No	No	No	8	6
382	6x29	6x32	dop_on	0	1.32	No	No	No	No	5	7
383	1x60	8x57	dop_on	0	1.17	No	No	No	No	5	0

Orange: nodes, hubs and links specific of dop_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of dop_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	dop_off Avg Int. Strength	dop_on Avg Int. Strength	dop_off Num Of Links	dop_on Num Of Links	ConSurf
1	1x39	dop_off	3.63	9.555	4	2	8
2	2x45	dop_off	9.61	6.14333	4	3	9
3	2x50	dop_off	6.955	1.95	4	1	9
4	2x57	dop_off	3.462	7.69333	5	3	7
5	3x37	dop_off	5.06	4.5	4	3	6
6	3x43	dop_off	4.49	3.835	4	2	8
7	3x49	dop_off	9.5425	10.555	4	2	8
8	5x61	dop_off	4.665	4.74667	4	3	8
9	6x30	dop_off	2.62	6.32	4	2	7
10	6x34	dop_off	6.6725	3.93333	4	3	7
11	6x44	dop_off	10.885	8.02	4	2	9
12	7x27	dop_off	3.79	4.99667	4	3	3
13	7x42	dop_off	8.2225	11.9033	4	3	7
14	7x45	dop_off	5.655	9.42	4	3	9
15	7x53	dop_off	6.9125	6.9	4	3	9
16	8x47	dop_off	7.5425	5.41	4	2	8
17	Lig	Shared	9.23	12.8783	11	18	0
18	2x42	Shared	7.906	6.23	5	4	7
19	E1x50	Shared	5.352	6.65833	5	6	8
20	E1x52	Shared	8.155	8.266	4	5	6
21	3x34	Shared	5.43	6.875	5	4	4
22	3x51	Shared	6.76	7.7575	5	4	8
23	4x50	Shared	8.79	8.4125	4	4	9
24	E2	Shared	12.744	10.372	10	15	4
25	5x44	Shared	5.8225	5.7375	4	4	5
26	5x47	Shared	6.138	5.194	5	5	7
27	5x58	Shared	7.3	6.05833	4	6	9
28	6x48	Shared	9.24667	5.82833	6	6	8
29	1x36	dop_on	6.18667	4.805	3	4	6
30	1x53	dop_on	5.05	3.2425	1	4	8
31	2x41	dop_on	2.46333	2.95	3	4	5
32	2x43	dop_on	9.67	2.5575	1	4	8
33	2x44	dop_on	4.385	6.5925	2	4	5
34	2x64	dop_on	7.78	6.4925	2	4	5
35	E2x50	dop_on	6.09667	5.6425	3	4	9
36	5x40	dop_on	6.66667	8.505	3	4	5
37	I3	dop_on	0	5.13571	0	7	4
38	6x52	dop_on	8.12667	4.1375	3	4	7
39	E3	dop_on	11.8333	11.242	3	5	1
40	7x49	dop_on	7.435	5.7	2	4	9
41	8x50	dop_on	7.21667	6.0825	3	4	8

Orange: nodes, hubs and links specific of dop_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of dop_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	dop_off Recurrence	dop_on Recurrence	dop_off Hub1?	dop_on Hub1?	dop_off Hub2?	dop_on Hub2?	ConSurf1	ConSurf2
1	5x40	Lig	dop_off	39.9834	5.14248	No	Yes	Yes	Yes	5	0
2	5x43	Lig	dop_off	39.7439	1.35079	No	No	Yes	Yes	5	0
3	6x48	Lig	dop_off	80.1418	0	Yes	Yes	Yes	Yes	8	0
4	1x39	2x57	dop_off	22.2806	0	Yes	No	Yes	No	8	7
5	1x36	2x61	dop_off	11.3659	1.54038	No	Yes	No	No	6	7
6	1x39	2x61	dop_off	13.5857	0	Yes	No	No	No	8	7
7	2x54	2x57	dop_off	13.5857	0	No	No	Yes	No	6	7
8	1x50	2x50	dop_off	10.6751	0	No	No	Yes	No	9	9
9	2x50	7x49	dop_off	20.899	0	Yes	No	No	Yes	9	9
10	7x49	7x53	dop_off	22.8885	7.84999	No	Yes	Yes	No	9	9
11	6x36	7x53	dop_off	28.728	0	No	No	Yes	No	8	9
12	6x36	8x47	dop_off	38.1137	0	No	No	Yes	No	8	8
13	6x32	8x47	dop_off	58.6166	0	No	No	Yes	No	7	8
14	6x32	6x33	dop_off	63.2127	0	No	No	No	No	7	7
15	3x50	6x33	dop_off	64.7508	0	No	No	No	No	9	7
16	3x50	6x34	dop_off	67.6983	0	No	No	Yes	No	9	7
17	5x61	6x34	dop_off	83.6603	0	Yes	No	Yes	No	8	7
18	3x47	5x58	dop_off	75.8865	1.53445	No	No	Yes	Yes	9	9
19	3x47	5x54	dop_off	76.2826	0	No	No	No	No	9	8
20	5x54	6x41	dop_off	77.4431	0	No	No	No	No	8	7
21	3x43	6x41	dop_off	78.9352	0	Yes	No	No	No	8	7
22	3x43	6x44	dop_off	87.5748	0	Yes	No	Yes	No	8	9
23	6x44	6x48	dop_off	82.4169	2.86154	Yes	No	Yes	Yes	9	8
24	2x45	4x50	dop_off	32.4123	6.65324	Yes	No	Yes	Yes	9	9
25	2x45	4x49	dop_off	36.1978	0	Yes	No	No	No	9	7
26	3x41	4x49	dop_off	37.7176	0	No	No	No	No	4	7
27	3x37	3x41	dop_off	37.865	1.50483	Yes	No	No	No	6	4
28	3x37	5x43	dop_off	38.3347	0	Yes	No	No	No	6	5
29	1x60	I1x50	dop_off	10.6751	0	No	No	No	No	5	6
30	8x50	I1x50	dop_off	12.7567	0	No	Yes	No	No	8	6
31	8x47	8x50	dop_off	20.899	0	Yes	No	No	Yes	8	8
32	2x45	4x46	dop_off	44.9019	7.41158	Yes	No	No	No	9	7
33	2x42	3x46	dop_off	30.4228	0	Yes	Yes	No	No	7	8
34	2x42	3x49	dop_off	16.3028	5.88897	Yes	Yes	Yes	No	7	8
35	2x46	3x43	dop_off	15.9805	0	No	No	Yes	No	9	8
36	2x46	3x42	dop_off	16.4318	5.72901	No	No	No	No	9	7
37	3x28	E1x50	dop_off	11.1817	0	No	No	Yes	Yes	5	8
38	2x63	E1x50	dop_off	38.5005	0.0651697	No	No	Yes	Yes	5	8
39	2x60	2x63	dop_off	44.248	0	No	No	No	No	6	5
40	5x36	E2	dop_off	27.9267	1.95509	No	No	Yes	Yes	5	4
41	5x36	5x40	dop_off	29.9991	1.46928	No	No	No	Yes	5	5
42	E1x50	E2x50	dop_off	11.2094	0.11849	Yes	Yes	No	Yes	8	9
43	3x34	4x50	dop_off	18.8081	4.49079	Yes	Yes	Yes	Yes	4	9
44	3x36	6x52	dop_off	13.9265	0	No	No	No	Yes	6	7
45	5x58	6x37	dop_off	31.0859	1.54038	Yes	Yes	No	No	9	7
46	3x51	5x61	dop_off	22.8885	0	Yes	Yes	Yes	No	8	8
47	4x41	I2x56	dop_off	12.3238	0	No	No	No	No	5	4
48	5x35	E2	dop_off	11.3659	1.57	No	No	Yes	Yes	3	4
49	5x47	6x52	dop_off	45.3809	9.36074	Yes	Yes	No	Yes	7	7
50	5x44	5x47	dop_off	17.3989	0.112566	Yes	Yes	Yes	Yes	5	7
51	5x44	5x48	dop_off	11.7804	4.24196	Yes	Yes	No	No	5	4
52	6x30	6x34	dop_off	20.7055	4.55596	Yes	No	Yes	No	7	7
53	5x65	6x30	dop_off	12.4528	0	No	No	Yes	No	8	7
54	5x65	5x66	dop_off	10.6751	0	No	No	No	No	8	5
55	6x58	Lig	dop_off	15.3818	6.51697	No	No	Yes	Yes	4	0
56	6x58	E3	dop_off	13.3831	5.2906	No	No	No	Yes	4	1
57	7x42	Lig	dop_off	84.8116	0	Yes	No	Yes	Yes	7	0
58	2x45	3x42	dop_off	14.8015	8.47207	Yes	No	No	No	9	7
59	3x46	6x37	dop_off	29.8425	0	No	No	No	No	8	7
60	3x36	Lig	Shared	14.9489	31.5185	No	No	Yes	Yes	6	0
61	2x57	7x42	Shared	46.5967	99.0817	Yes	No	Yes	No	7	7
62	5x58	5x61	Shared	100	24.0536	Yes	Yes	Yes	No	9	8
63	2x41	4x46	Shared	10.6751	37.9229	No	Yes	No	No	5	7
64	2x42	4x46	Shared	41.6413	33.1122	Yes	Yes	No	No	7	7
65	2x42	4x45	Shared	12.2133	24.1839	Yes	Yes	No	No	7	5
66	2x60	7x42	Shared	46.0072	99.3009	No	No	Yes	No	6	7
67	E1x50	E1x52	Shared	13.5489	13.0754	Yes	Yes	Yes	Yes	8	6
68	6x48	6x52	Shared	34.1255	24.6875	Yes	Yes	No	Yes	8	7
69	2x64	7x35	dop_on	2.12766	13.3776	No	Yes	No	No	5	4
70	1x39	7x35	dop_on	0	16.245	Yes	No	No	No	8	4
71	1x39	7x38	dop_on	0	17.661	Yes	No	No	No	8	5
72	7x38	Lig	dop_on	6.84351	18.4727	No	No	Yes	Yes	5	0
73	2x60	Lig	dop_on	0	100	No	No	Yes	Yes	6	0
74	1x42	2x57	dop_on	6.87114	12.0327	No	No	Yes	No	7	7
75	1x43	2x57	dop_on	4.59611	96.8956	No	No	Yes	No	6	7
76	1x43	1x47	dop_on	0	96.2794	No	No	No	No	6	6
77	1x47	2x54	dop_on	6.87114	95.9536	No	No	No	No	6	6
78	2x54	7x47	dop_on	0	95.6159	No	No	No	No	6	7
79	1x50	7x47	dop_on	0	94.9049	No	No	No	No	9	7
80	1x50	7x51	dop_on	0	94.1466	No	No	No	No	9	6
81	1x53	7x51	dop_on	0	92.9202	No	Yes	No	No	8	6
82	1x53	1x57	dop_on	0	87.6829	No	Yes	No	No	8	7
83	1x53	7x54	dop_on	0	13.1821	No	Yes	No	No	8	6
84	1x57	2x44	dop_on	0	62.4978	No	No	No	Yes	7	5
85	1x54	2x44	dop_on	4.30137	16.7309	No	No	No	Yes	7	5
86	1x54	2x48	dop_on	6.42903	15.4985	No	No	No	No	7	6
87	7x54	8x50	dop_on	0	11.7187	No	No	No	Yes	6	8
88	1x57	2x43	dop_on	0	44.0666	No	No	No	Yes	7	8
89	2x44	I1x50	dop_on	0	44.3273	No	Yes	No	No	5	6
90	2x41	I1x50	dop_on	0	43.2549	No	Yes	No	No	5	6
91	2x43	3x46	dop_on	0	34.5103	No	Yes	No	No	8	8
92	2x48	4x50	dop_on	8.53827	14.4321	No	No	Yes	Yes	6	9
93	2x56	2x60	dop_on	0	10.4331	No	No	No	No	5	6
94	E1x50	Lig	dop_on	0	15.8896	Yes	Yes	Yes	Yes	8	0
95	E2	Lig	dop_on	0	31.0149	Yes	Yes	Yes	Yes	4	0
96	3x36	6x48	dop_on	1.17896	24.1424	No	No	Yes	Yes	6	8
97	6x52	Lig	dop_on	0	41.0392	No	Yes	Yes	Yes	7	0
98	3x40	6x48	dop_on	0	18.1587	No	No	Yes	Yes	7	8
99	3x40	5x50	dop_on	6.4843	13.028	No	No	No	No	7	9
100	6x48	7x45	dop_on	5.8856	23.2419	Yes	Yes	Yes	No	8	9
101	7x45	7x49	dop_on	0	18.1587	Yes	No	No	Yes	9	9
102	3x46	3x50	dop_on	0	33.2484	No	No	No	No	8	9
103	3x50	5x58	dop_on	0	31.9746	No	No	Yes	Yes	9	9
104	4x45	I2x56	dop_on	0	20.1374	No	No	No	No	5	4
105	3x52	I2x56	dop_on	8.35406	18.9407	No	No	No	No	5	4
106	3x48	3x52	dop_on	0	17.5544	No	No	No	No	6	5
107	3x48	5x57	dop_on	2.1645	16.1562	No	No	No	No	6	6
108	3x51	5x57	dop_on	4.31979	14.7461	Yes	Yes	No	No	8	6
109	5x61	5x65	dop_on	0	18.5319	Yes	No	No	No	8	8
110	5x65	I3	dop_on	0	17.0922	No	No	No	Yes	8	4

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
3x32	Lig	dop_off	16.81	0	1	0	1	0
3x33	Lig	Shared	12.1	13.68	0	1	1	0
3x36	Lig	Shared	13.62	8.38	1	1	1	0
5x40	Lig	Shared	5.82	12.16	0	1	1	0
5x43	Lig	Shared	4.1	5.05	0	0	1	0
6x48	Lig	dop_off	7.06	0	1	0	1	0
6x51	Lig	dop_off	4.91	0	1	0	1	0
6x55	Lig	Shared	17.43	4.04	0	1	1	0
7x38	Lig	Shared	6.88	10.25	1	1	1	0
7x42	Lig	dop_off	8.88	0	1	0	1	0
2x56	3x28	dop_off	9.52	0	0	0	2	2
2x57	7x42	Shared	4.69	15.24	0	0	2	1
2x60	2x63	dop_off	8.14	0	0	1	1	1
2x60	7x42	Shared	11.27	11.27	0	1	1	1
2x63	E1x50	Shared	4.64	4.64	0	1	1	1
E1x49	E2	Shared	6.53	4.85	2	0	2	1
E1x50	E1x52	Shared	9.02	17.04	0	1	1	2
E1x50	E2x50	Shared	7.84	6.53	0	1	1	1
3x22	E2	Shared	16.99	8.49	0	1	2	1
3x25	E2x50	Shared	7.28	7.28	0	1	2	1
3x32	7x42	Shared	8.05	9.2	1	0	1	1
3x33	4x60	Shared	9.67	12.09	0	1	1	2
3x36	6x48	Shared	8.14	5.82	1	1	1	1
3x36	6x52	dop_off	6.57	0	1	1	1	1
3x37	5x43	dop_off	5.24	0	0	0	2	1
3x40	6x44	dop_off	8.79	0	0	0	2	2
E2	E2	Shared	36.45	33.94	2	1	1	1
E2	E2x51	Shared	5.92	5.24	2	1	1	2
5x35	E2	Shared	4.01	9.77	2	0	2	1
5x36	E2	Shared	9.55	14.33	2	1	2	1
5x39	E2	Shared	6.49	9.08	0	0	2	1
5x36	5x40	Shared	9.68	8.3	2	1	2	1
5x40	6x59	Shared	4.5	9.01	0	1	1	2
5x44	5x47	Shared	4.29	9.65	1	1	2	2
5x47	6x52	Shared	13.58	3.39	1	1	2	1
6x44	6x48	Shared	25.05	11.02	1	0	2	1
6x44	7x45	dop_off	4.83	0	1	0	2	2
6x48	6x52	Shared	4.23	4.23	1	0	1	1
6x48	7x41	dop_off	4.22	0	1	0	1	2
6x48	7x45	Shared	6.78	7.91	1	0	1	2
6x51	7x38	dop_off	4.42	0	1	0	1	1
6x54	7x34	Shared	8.53	9.74	0	0	2	1
6x58	E3	Shared	20.04	5	0	1	1	2
6x58	Lig	Shared	3.92	6.13	0	1	1	0
4x63	E2	Shared	3.73	3.73	0	1	2	1
2x63	2x64	dop_off	3.58	0	0	1	1	2
1x39	2x57	dop_off	3.52	0	0	0	2	2
3x33	E2x52	dop_off	3.52	0	0	1	1	1
3x29	E2x50	Shared	3.17	3.17	0	1	1	1
3x29	4x64	dop_off	3.15	0	0	1	1	2
7x34	7x38	Shared	2.85	4.28	0	1	1	1
3x21	E1x50	Shared	2.81	2.81	0	0	2	1
3x28	E1x50	dop_off	2.45	0	0	0	2	1
5x32	E2	Shared	1.32	2.64	0	0	2	1
1x39	7x38	dop_on	0	6.04	0	0	2	1
2x56	2x60	dop_on	0	5.67	0	0	2	1
2x60	Lig	dop_on	0	10.54	0	1	1	0
2x63	Lig	dop_on	0	15.2	0	1	1	0
3x25	E1x50	dop_on	0	3.92	0	1	2	1
E1x50	Lig	dop_on	0	5.01	0	1	1	0
3x25	E2	dop_on	0	3.38	0	1	2	1
3x29	Lig	dop_on	0	4.87	0	1	1	0
3x36	3x37	dop_on	0	3.73	1	1	1	2
3x40	6x48	dop_on	0	3.52	0	0	2	1
4x60	E2x52	dop_on	0	4.28	0	0	2	1
E2	E3	dop_on	0	11.73	2	1	1	2
E2	Lig	dop_on	0	3.68	2	1	1	0
E2x50	Lig	dop_on	0	5.59	0	1	1	0
E2	E2x52	dop_on	0	3.65	2	1	1	1
E2x52	Lig	dop_on	0	5.3	0	1	1	0
5x31	E2	dop_on	0	7.13	0	1	2	1
5x36	6x59	dop_on	0	2.89	2	1	2	2
5x40	6x55	dop_on	0	4.55	0	1	1	1
5x44	6x52	dop_on	0	5.66	1	1	2	1
6x51	6x55	dop_on	0	3.07	1	0	1	1
6x51	7x37	dop_on	0	3.27	1	0	1	2
6x52	Lig	dop_on	0	3.27	1	1	1	0
E3	E3	dop_on	0	16.67	0	1	2	2
7x34	Lig	dop_on	0	5.96	0	1	1	0
6x48	7x46	dop_on	0	2.47	1	0	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	dop_off	4EJ4-δ-Naltrindole
	dop_on	8F7S-δ-Deltorphin-Gi1/β1/γ2

Network Difference
Value	dop_off	dop_on
I_min	4	2.83
Number of Linked Nodes	241	239
Number of Specific Nodes	18 (7.47%)	16 (6.69%)
Number of Shared Nodes	223 (92.53%)	223 (93.31%)
Number of Links	250	259
Number of Specific Links	124 (49.60%)	133 (51.35%)
Number of Shared Links	126 (50.40%)	126 (48.65%)
Number of Hubs	28	25
Number of Specific Hubs	16 (57.14%)	13 (52.00%)
Number of Shared Hubs	12 (42.86%)	12 (48.00%)
Average % Shared Neighbours (Jaccard)	34.93
Average % Shared Neighbours (Otsuka)	43.26
Average % Shared Neighbours (Overlap Coefficient)	52.03
Average % Shared Cliques (k3-6)	75.00
Graphlets Similarity	0.446741

Paths Difference
Value	dop_off	dop_on
Number Of Nodes in MetaPath	67	51
Specific Nodes in MetaPath	39 (58.21%)	23 (45.10%)
Shared Nodes in MetaPath	223 (92.53%)	223 (92.53%)
Number Of Links MetaPath	68	51
Specific Links in MetaPath	59 (86.76%)	42 (82.35%)
Shared Links in MetaPath	126 (50.40%)	126 (50.40%)
Number of Shortest Paths	28708	32407
Length Of Smallest Path	3	3
Average Path Length	12.4765	14.5835
Length of Longest Path	30	33
Minimum Path Strength	1.295	1.435
Average Path Strength	7.21262	6.02211
Maximum Path Strength	17.12	14.44
Minimum Path Correlation	0.7	0.7
Average Path Correlation	0.922362	0.917827
Maximum Path Correlation	0.99	0.99
Minimum % Of Corr. Nodes	4.7619	3.7037
Average % Of Corr. Nodes	51.5426	48.4744
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	43.3544	29.4231
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download dop_off_on.zip<

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