psnGPCR

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Orange: nodes, hubs and links specific of dopamine_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of dopamine_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	dopamine_off Int. Strength	dopamine_on Int. Strength	dopamine_off Hub1?	dopamine_on Hub1?	dopamine_off Hub2?	dopamine_on Hub2?	ConSurf1	ConSurf2
1	1x35	7x39	dopamine_off	100	0	Yes	No	Yes	Yes	5	8
2	1x39	2x64	dopamine_off	100	0	Yes	No	Yes	Yes	7	7
3	1x46	7x46	dopamine_off	100	0	Yes	Yes	No	No	8	9
4	1x47	2x51	dopamine_off	100	0	No	No	No	No	7	8
5	1x53	7x50	dopamine_off	100	0	No	No	No	No	9	9
6	1x53	7x53	dopamine_off	100	0	No	No	Yes	Yes	9	9
7	8x49	I1x49	dopamine_off	100	0	Yes	No	No	No	7	7
8	2x38	3x49	dopamine_off	100	0	No	Yes	Yes	No	7	8
9	2x39	3x50	dopamine_off	100	0	No	No	Yes	No	8	9
10	2x42	3x46	dopamine_off	100	0	No	Yes	No	No	8	9
11	2x46	3x39	dopamine_off	100	0	No	Yes	No	No	9	9
12	2x62	E1x51	dopamine_off	100	0	No	No	No	No	6	4
13	3x21	3x24	dopamine_off	100	0	No	No	Yes	No	8	6
14	3x33	4x61	dopamine_off	100	0	No	No	No	No	8	8
15	3x34	3x35	dopamine_off	100	0	No	No	No	No	7	7
16	3x37	4x56	dopamine_off	100	0	No	No	No	No	8	8
17	3x39	6x44	dopamine_off	100	0	No	No	Yes	Yes	9	9
18	3x40	5x50	dopamine_off	100	0	No	No	No	No	9	9
19	3x40	6x44	dopamine_off	100	0	No	No	Yes	Yes	9	9
20	3x43	6x44	dopamine_off	100	0	No	No	Yes	Yes	8	9
21	3x44	5x54	dopamine_off	100	0	Yes	No	No	No	7	9
22	3x46	6x37	dopamine_off	100	0	No	No	No	No	9	8
23	3x49	3x50	dopamine_off	100	0	Yes	No	Yes	No	8	9
24	3x49	4x41	dopamine_off	100	0	Yes	No	No	No	8	8
25	3x50	3x53	dopamine_off	100	0	Yes	No	No	No	9	8
26	3x50	6x30	dopamine_off	100	0	Yes	No	No	Yes	9	9
27	3x50	6x34	dopamine_off	100	0	Yes	No	No	No	9	8
28	4x54	4x59	dopamine_off	100	0	No	No	No	No	6	6
29	4x56	5x42	dopamine_off	100	0	No	No	No	No	8	7
30	4x59	4x63	dopamine_off	100	0	No	No	No	No	6	6
31	4x60	E2	dopamine_off	100	0	No	No	Yes	Yes	8	5
32	4x62	4x63	dopamine_off	100	0	No	No	No	No	7	6
33	5x36	5x37	dopamine_off	100	0	No	No	No	No	7	4
34	5x42	5x46	dopamine_off	100	0	No	No	No	No	7	6
35	5x51	6x45	dopamine_off	100	0	No	No	No	No	7	7
36	5x58	5x61	dopamine_off	100	0	Yes	Yes	No	No	9	9
37	5x58	6x38	dopamine_off	100	0	Yes	Yes	No	No	9	8
38	5x65	6x31	dopamine_off	100	0	Yes	No	No	No	8	7
39	6x36	7x53	dopamine_off	100	0	No	No	Yes	Yes	9	9
40	6x40	7x49	dopamine_off	100	0	No	No	No	Yes	9	9
41	6x40	7x52	dopamine_off	100	0	No	No	No	No	9	8
42	6x44	7x45	dopamine_off	100	0	Yes	Yes	No	No	9	9
43	6x48	6x51	dopamine_off	100	0	Yes	Yes	Yes	Yes	9	8
44	6x48	Lig	dopamine_off	100	0	Yes	Yes	Yes	Yes	9	0
45	6x55	7x34	dopamine_off	100	0	Yes	Yes	Yes	No	8	5
46	7x34	7x38	dopamine_off	100	0	Yes	No	No	No	5	8
47	7x49	7x53	dopamine_off	100	0	No	Yes	Yes	Yes	9	9
48	7x53	8x50	dopamine_off	100	0	Yes	Yes	Yes	Yes	9	9
49	8x47	8x49	dopamine_off	100	0	No	No	Yes	No	9	7
50	E3	E3	dopamine_off	100	0	Yes	Yes	Yes	Yes	4	4
51	5x39	5x42	dopamine_off	100	0	Yes	Yes	No	No	8	7
52	6x59	6x60	dopamine_off	100	0	No	No	No	No	6	6
53	3x22	3x25	dopamine_off	100	0	No	No	No	No	3	9
54	3x50	I2x53	dopamine_off	100	0	Yes	No	Yes	Yes	9	0
55	6x28	6x32	dopamine_off	100	0	No	No	No	No	6	9
56	7x39	7x43	dopamine_off	100	0	Yes	Yes	No	No	8	6
57	5x54	6x41	dopamine_off	66.6667	0	No	No	No	No	9	8
58	8x48	8x49	dopamine_off	50	0	No	No	Yes	No	5	7
59	1x42	2x57	dopamine_off	50	0	No	No	Yes	No	7	9
60	1x48	1x49	dopamine_off	50	0	No	No	No	No	5	9
61	6x27	I2x54	dopamine_off	50	0	No	No	No	No	5	0
62	5x68	6x28	dopamine_off	50	0	No	No	No	No	8	6
63	3x28	3x29	dopamine_off	50	0	No	No	No	No	7	6
64	2x53	2x57	dopamine_off	33.3333	0	No	No	Yes	No	8	9
65	4x41	4x45	dopamine_off	50	0	No	No	No	No	8	8
66	1x52	8x57	dopamine_off	16.6667	0	No	No	No	No	8	8
67	3x50	6x37	dopamine_off	16.6667	0	Yes	No	No	No	9	8
68	3x41	3x44	dopamine_off	66.6667	0	No	No	Yes	No	8	7
69	1x39	2x60	dopamine_off	50	0	Yes	No	No	Yes	7	8
70	7x43	7x48	dopamine_off	50	0	No	No	No	No	6	7
71	3x50	6x33	dopamine_off	50	0	Yes	No	No	No	9	9
72	4x39	4x43	dopamine_off	50	0	No	No	No	No	6	5
73	6x26	I2x50	dopamine_off	16.6667	0	No	No	No	No	6	9
74	4x36	4x40	dopamine_off	50	0	No	No	No	No	8	6
75	1x33	1x35	dopamine_off	50	0	No	No	Yes	No	7	5
76	5x67	5x70	dopamine_off	50	0	Yes	No	No	No	6	7
77	2x48	4x50	dopamine_off	33.3333	0	No	No	Yes	No	7	9
78	5x51	5x55	dopamine_off	50	0	No	No	No	No	7	6
79	6x29	6x30	dopamine_off	50	0	No	No	No	Yes	7	9
80	1x57	2x41	dopamine_off	0	0	No	No	No	No	8	7
81	1x54	2x44	dopamine_off	16.6667	0	No	No	No	No	7	7
82	I2	I2x55	dopamine_off	0	0	No	No	No	No	0	0
83	5x65	5x68	dopamine_off	0	0	Yes	No	No	No	8	8
84	5x60	5x63	dopamine_off	0	0	No	No	No	No	7	5
85	7x54	8x51	dopamine_off	0	0	No	No	No	No	8	9
86	7x30	E3	dopamine_off	50	0	Yes	No	Yes	Yes	6	4
87	2x57	2x58	dopamine_off	0	0	Yes	No	No	No	9	9
88	5x61	5x65	dopamine_off	0	0	No	No	Yes	No	9	8
89	3x44	3x48	dopamine_off	16.6667	0	Yes	No	No	No	7	7
90	6x32	6x35	dopamine_off	50	0	No	No	No	No	9	8
91	4x39	4x42	dopamine_off	16.6667	0	No	No	No	No	6	7
92	5x55	5x56	dopamine_off	0	0	No	No	No	No	6	5
93	3x27	4x62	dopamine_off	0	0	No	No	No	No	6	7
94	1x43	1x44	dopamine_off	0	0	No	No	No	No	8	5
95	5x52	5x56	dopamine_off	0	0	No	No	No	No	4	5
96	8x55	8x59	dopamine_off	33.3333	0	No	No	No	No	5	5
97	5x41	5x45	dopamine_off	33.3333	0	No	No	No	No	7	6
98	4x52	4x55	dopamine_off	16.6667	0	No	No	No	No	7	5
99	2x66	2x67	dopamine_off	0	0	No	No	No	No	5	5
100	5x67	5x71	dopamine_off	16.6667	0	Yes	No	No	No	6	6
101	5x71	6x25	dopamine_off	0	0	No	No	No	No	6	0
102	8x51	8x55	dopamine_off	0	0	No	No	No	No	9	5
103	4x43	4x47	dopamine_off	0	0	No	No	No	No	5	5
104	4x34	4x38	dopamine_off	16.6667	0	No	No	No	No	7	6
105	1x54	1x58	dopamine_off	0	0	No	No	No	No	7	6
106	I2x55	I2x56	dopamine_off	0	0	No	No	No	No	0	0
107	1x36	1x37	dopamine_off	0	0	No	No	No	No	7	6
108	1x35	7x36	dopamine_off	0	0	Yes	No	No	No	5	6
109	4x35	4x39	dopamine_off	16.6667	0	No	No	No	No	7	6
110	5x67	5x69	dopamine_off	0	0	Yes	No	No	No	6	6
111	2x65	2x66	dopamine_off	16.6667	0	No	No	No	No	6	5
112	3x56	I2x51	dopamine_off	0	0	No	No	No	No	6	0
113	1x34	1x38	dopamine_off	0	0	No	No	No	No	5	5
114	1x35	1x38	dopamine_off	0	0	Yes	No	No	No	5	5
115	1x35	2x64	Shared	100	10	Yes	No	Yes	Yes	5	7
116	1x39	7x39	Shared	100	100	Yes	No	Yes	Yes	7	8
117	1x42	1x46	Shared	100	40	No	No	Yes	Yes	7	8
118	1x43	2x57	Shared	100	100	No	No	Yes	No	8	9
119	1x46	2x54	Shared	100	21.1111	Yes	Yes	No	No	8	8
120	1x49	7x50	Shared	100	66.6667	No	No	No	No	9	9
121	1x50	2x47	Shared	100	73.3333	Yes	Yes	No	No	9	9
122	1x50	2x50	Shared	100	100	Yes	Yes	No	Yes	9	9
123	1x50	2x51	Shared	100	100	Yes	Yes	No	No	9	8
124	1x50	7x50	Shared	100	100	Yes	Yes	No	No	9	9
125	1x52	8x54	Shared	100	100	No	No	Yes	Yes	8	9
126	1x55	8x57	Shared	100	34.4444	No	No	No	No	5	8
127	1x57	2x44	Shared	100	100	No	No	No	No	8	7
128	1x60	I1x50	Shared	100	100	No	Yes	No	No	8	9
129	1x60	8x53	Shared	100	100	No	Yes	No	No	8	9
130	I1x48	I1x51	Shared	100	100	No	No	No	No	8	8
131	8x49	I1x50	Shared	100	53.3333	Yes	No	No	No	7	9
132	8x50	I1x50	Shared	100	100	Yes	Yes	No	No	9	9
133	2x41	I1x51	Shared	100	22.2222	No	No	No	No	7	8
134	2x37	2x40	Shared	100	100	No	No	No	No	8	9
135	2x38	4x42	Shared	100	40	No	Yes	No	No	7	7
136	2x39	3x49	Shared	100	100	No	No	Yes	No	8	8
137	2x40	8x50	Shared	100	100	No	No	Yes	Yes	9	9
138	2x43	7x53	Shared	100	40	No	No	Yes	Yes	8	9
139	2x45	3x42	Shared	100	100	No	No	No	No	9	8
140	2x45	4x46	Shared	100	100	No	No	No	No	9	9
141	2x45	4x50	Shared	100	100	No	No	Yes	No	9	9
142	2x46	3x42	Shared	100	100	No	Yes	No	No	9	8
143	2x50	7x46	Shared	100	100	No	Yes	No	No	9	9
144	2x52	2x551	Shared	100	28.8889	No	No	No	No	7	5
145	2x52	3x35	Shared	100	100	No	No	No	No	7	7
146	2x55	2x551	Shared	100	40	No	No	No	No	6	5
147	2x56	3x32	Shared	100	100	No	No	No	No	8	8
148	2x57	7x42	Shared	100	100	Yes	No	Yes	Yes	9	8
149	2x59	3x24	Shared	100	100	No	No	Yes	No	6	6
150	2x59	3x28	Shared	100	100	No	No	No	No	6	7
151	2x60	7x42	Shared	100	100	No	Yes	Yes	Yes	8	8
152	2x62	2x66	Shared	100	100	No	No	No	No	6	5
153	2x62	E1x52	Shared	100	56.6667	No	No	No	Yes	6	7
154	2x63	E1x50	Shared	100	36.6667	No	No	Yes	Yes	7	9
155	2x64	7x39	Shared	100	100	Yes	Yes	Yes	Yes	7	8
156	E1x49	E1x51	Shared	100	100	No	No	No	No	4	4
157	E1x50	E1x52	Shared	100	100	Yes	Yes	No	Yes	9	7
158	3x25	E1x50	Shared	100	100	No	No	Yes	Yes	9	9
159	3x24	E1x52	Shared	100	100	Yes	No	No	Yes	6	7
160	3x21	3x23	Shared	100	20	No	No	No	No	8	4
161	3x25	E2x50	Shared	100	100	No	No	No	No	9	9
162	3x30	4x61	Shared	100	100	No	No	No	No	8	8
163	3x30	4x62	Shared	100	100	No	No	No	No	8	7
164	3x32	7x42	Shared	100	100	No	No	Yes	Yes	8	8
165	3x32	Lig	Shared	100	100	No	No	Yes	Yes	8	0
166	3x33	4x57	Shared	100	100	No	No	No	No	8	9
167	3x33	Lig	Shared	100	100	No	No	Yes	Yes	8	0
168	3x34	4x54	Shared	100	100	No	No	No	No	7	6
169	3x34	4x57	Shared	100	100	No	No	No	No	7	9
170	3x36	6x48	Shared	100	100	No	No	Yes	Yes	8	9
171	3x36	Lig	Shared	100	100	No	No	Yes	Yes	8	0
172	3x37	5x461	Shared	100	100	No	No	No	No	8	8
173	3x38	4x50	Shared	100	100	No	No	Yes	No	8	9
174	3x41	4x52	Shared	100	100	No	No	No	No	8	7
175	3x41	5x50	Shared	100	45.5556	No	No	No	No	8	9
176	3x42	4x49	Shared	100	100	No	No	No	No	8	9
177	3x47	5x54	Shared	100	100	No	No	No	No	9	9
178	3x47	5x57	Shared	100	100	No	No	No	No	9	7
179	3x47	5x58	Shared	100	100	No	No	Yes	Yes	9	9
180	3x51	3x55	Shared	100	100	No	Yes	No	No	8	8
181	3x54	5x64	Shared	100	60	No	No	No	No	8	7
182	3x54	5x65	Shared	100	20	No	No	Yes	No	8	8
183	4x56	5x46	Shared	100	22.2222	No	No	No	No	8	6
184	4x61	5x39	Shared	100	100	No	No	Yes	Yes	8	8
185	E2	E2	Shared	100	100	Yes	Yes	Yes	Yes	5	5
186	E2	E2x51	Shared	100	100	Yes	Yes	No	No	5	5
187	5x36	E2	Shared	100	100	No	No	Yes	Yes	7	5
188	E2x52	Lig	Shared	100	100	No	No	Yes	Yes	7	0
189	5x39	5x43	Shared	100	100	Yes	Yes	No	No	8	9
190	5x40	6x55	Shared	100	100	No	No	Yes	Yes	7	8
191	5x43	Lig	Shared	100	100	No	No	Yes	Yes	9	0
192	5x47	5x48	Shared	100	100	No	Yes	No	No	9	7
193	5x47	6x52	Shared	100	100	No	Yes	Yes	Yes	9	8
194	5x62	5x66	Shared	100	100	No	No	No	No	7	6
195	6x39	7x56	Shared	100	26.6667	No	No	No	No	8	8
196	6x44	6x48	Shared	100	100	Yes	Yes	Yes	Yes	9	9
197	6x47	7x45	Shared	100	100	No	No	No	No	9	9
198	6x48	6x52	Shared	100	100	Yes	Yes	Yes	Yes	9	8
199	6x48	7x41	Shared	100	100	Yes	Yes	No	No	9	8
200	6x49	6x53	Shared	100	51.1111	Yes	Yes	No	No	7	7
201	6x50	7x37	Shared	100	100	No	No	No	No	9	5
202	6x51	6x52	Shared	100	100	Yes	Yes	Yes	Yes	8	8
203	6x51	6x55	Shared	100	100	Yes	Yes	Yes	Yes	8	8
204	6x51	7x34	Shared	100	46.6667	Yes	Yes	Yes	No	8	5
205	6x51	7x38	Shared	100	100	Yes	Yes	No	No	8	8
206	6x51	Lig	Shared	100	100	Yes	Yes	Yes	Yes	8	0
207	6x52	Lig	Shared	100	100	Yes	Yes	Yes	Yes	8	0
208	6x54	7x37	Shared	100	100	No	No	No	No	5	5
209	6x58	E3	Shared	100	100	No	No	Yes	Yes	5	4
210	6x61	E3	Shared	100	100	No	No	Yes	Yes	6	4
211	7x30	7x33	Shared	100	100	Yes	No	No	No	6	6
212	7x38	Lig	Shared	100	100	No	No	Yes	Yes	8	0
213	7x42	Lig	Shared	100	100	Yes	Yes	Yes	Yes	8	0
214	7x54	8x54	Shared	100	100	No	No	Yes	Yes	8	9
215	7x55	7x56	Shared	100	20	No	No	No	No	7	8
216	8x47	8x50	Shared	100	100	No	No	Yes	Yes	9	9
217	8x50	8x54	Shared	100	100	Yes	Yes	Yes	Yes	9	9
218	2x64	7x35	Shared	100	100	Yes	Yes	No	No	7	6
219	3x24	E1x50	Shared	100	100	Yes	No	Yes	Yes	6	9
220	3x22	E2	Shared	100	20	No	No	Yes	Yes	3	5
221	3x26	E2	Shared	100	100	No	No	Yes	Yes	6	5
222	3x37	4x53	Shared	100	100	No	No	No	No	8	8
223	6x50	7x40	Shared	100	6.66667	No	No	No	No	9	8
224	E1x50	E2x50	Shared	100	100	Yes	Yes	No	No	9	9
225	6x55	Lig	Shared	100	100	Yes	Yes	Yes	Yes	8	0
226	3x49	I2x53	Shared	100	100	Yes	No	Yes	Yes	8	0
227	3x53	I2x53	Shared	100	100	No	No	Yes	Yes	8	0
228	I2x53	I2x57	Shared	100	100	Yes	Yes	No	No	0	0
229	5x49	5x50	Shared	50	38.8889	No	No	No	No	8	9
230	8x48	8x52	Shared	66.6667	20	No	No	No	No	5	6
231	4x60	5x39	Shared	50	100	No	No	Yes	Yes	8	8
232	3x52	4x41	Shared	50	100	No	No	No	No	6	8
233	3x51	5x61	Shared	50	100	No	Yes	No	No	8	9
234	1x51	2x51	Shared	16.6667	0	No	No	No	No	6	8
235	5x58	6x37	Shared	66.6667	100	Yes	Yes	No	No	9	8
236	6x27	6x30	Shared	50	40	No	No	No	Yes	5	9
237	3x51	5x60	Shared	50	100	No	Yes	No	No	8	7
238	3x44	5x53	Shared	16.6667	100	Yes	No	No	No	7	8
239	6x45	6x49	Shared	50	6.66667	No	No	Yes	Yes	7	7
240	1x57	8x50	Shared	50	0	No	No	Yes	Yes	8	9
241	5x47	6x49	Shared	0	100	No	Yes	Yes	Yes	9	7
242	2x53	3x35	Shared	33.3333	100	No	No	No	No	8	7
243	1x39	2x61	Shared	50	100	Yes	No	No	No	7	8
244	1x59	8x57	Shared	50	100	No	No	No	No	7	8
245	5x44	6x52	Shared	50	100	No	No	Yes	Yes	8	8
246	1x56	8x54	Shared	0	28.8889	No	No	Yes	Yes	9	9
247	7x30	7x32	Shared	66.6667	24.4444	Yes	No	No	No	6	4
248	6x49	6x50	Shared	16.6667	35.5556	Yes	Yes	No	No	7	9
249	5x41	6x60	Shared	50	24.4444	No	No	No	No	7	6
250	6x57	E3	Shared	50	8.88889	No	No	Yes	Yes	7	4
251	2x551	3x31	Shared	0	100	No	No	No	No	5	6
252	6x39	7x52	Shared	0	20	No	No	No	No	8	8
253	2x42	3x45	Shared	50	100	No	Yes	No	No	8	7
254	6x43	7x52	Shared	33.3333	36.6667	No	No	No	No	7	8
255	5x36	5x38	Shared	33.3333	53.3333	No	No	No	No	7	5
256	1x46	7x47	Shared	33.3333	100	Yes	Yes	No	No	8	7
257	5x63	5x67	Shared	50	20	No	No	Yes	No	5	6
258	5x55	5x59	Shared	50	10	No	No	No	No	6	4
259	1x45	7x47	Shared	16.6667	16.6667	No	No	No	No	5	7
260	3x56	I2x50	Shared	16.6667	0	No	No	No	No	6	9
261	2x49	4x50	Shared	0	40	No	No	Yes	No	8	9
262	6x58	7x34	Shared	50	100	No	No	Yes	No	5	5
263	2x38	4x38	Shared	16.6667	40	No	Yes	No	No	7	6
264	7x30	7x31	Shared	0	13.3333	Yes	No	No	No	6	3
265	6x26	6x27	Shared	0	4.44444	No	No	No	No	6	5
266	4x64	E2	Shared	50	26.6667	No	No	Yes	Yes	7	5
267	5x48	6x56	Shared	50	100	No	No	No	No	7	7
268	4x34	4x37	Shared	50	20	No	No	No	No	7	8
269	1x60	8x56	Shared	50	46.6667	No	Yes	No	No	8	7
270	5x37	6x60	Shared	0	100	No	No	No	No	4	6
271	3x27	3x31	Shared	0	40	No	No	No	No	6	6
272	1x40	2x61	Shared	16.6667	6.66667	No	No	No	No	4	8
273	7x51	7x55	Shared	0	46.6667	No	No	No	No	7	7
274	8x58	8x59	Shared	16.6667	0	No	No	No	No	8	5
275	4x44	4x48	Shared	33.3333	0	No	No	No	No	3	4
276	6x41	6x42	Shared	0	0	No	No	No	No	8	7
277	2x67	E1	Shared	0	0	No	No	No	No	5	0
278	1x34	1x35	Shared	16.6667	6.66667	No	No	Yes	No	5	5
279	1x36	2x65	Shared	0	22.2222	No	No	No	No	7	6
280	4x51	4x55	Shared	0	2.22222	No	No	No	No	5	5
281	4x47	4x51	Shared	0	0	No	No	No	No	5	5
282	1x37	1x41	Shared	16.6667	0	No	No	No	No	6	6
283	3x56	I2x52	Shared	0	100	No	No	No	Yes	6	0
284	5x66	5x70	Shared	16.6667	100	No	No	No	No	6	7
285	6x46	6x47	Shared	0	0	No	No	No	No	5	9
286	4x36	4x37	Shared	0	0	No	No	No	No	8	8
287	1x46	2x57	dopamine_on	0	100	Yes	Yes	Yes	No	8	9
288	2x39	I2x53	dopamine_on	0	100	No	No	Yes	Yes	8	0
289	2x42	3x49	dopamine_on	0	100	No	Yes	Yes	No	8	8
290	2x42	4x45	dopamine_on	0	100	No	Yes	No	No	8	8
291	2x42	4x46	dopamine_on	0	100	No	Yes	No	No	8	9
292	2x46	2x50	dopamine_on	0	100	No	Yes	No	Yes	9	9
293	2x46	3x43	dopamine_on	0	100	No	Yes	No	No	9	8
294	2x46	7x49	dopamine_on	0	100	No	Yes	No	Yes	9	9
295	2x50	3x39	dopamine_on	0	100	No	Yes	No	No	9	9
296	2x50	7x49	dopamine_on	0	100	No	Yes	No	Yes	9	9
297	2x56	7x42	dopamine_on	0	100	No	No	Yes	Yes	8	8
298	2x60	3x28	dopamine_on	0	100	No	Yes	No	No	8	7
299	2x60	7x39	dopamine_on	0	100	No	Yes	Yes	Yes	8	8
300	3x28	E1x50	dopamine_on	0	100	No	No	Yes	Yes	7	9
301	3x40	6x48	dopamine_on	0	100	No	No	Yes	Yes	9	9
302	3x43	7x53	dopamine_on	0	100	No	No	Yes	Yes	8	9
303	3x44	5x50	dopamine_on	0	100	Yes	No	No	No	7	9
304	3x46	3x50	dopamine_on	0	100	No	No	Yes	No	9	9
305	3x46	7x53	dopamine_on	0	100	No	No	Yes	Yes	9	9
306	3x50	5x58	dopamine_on	0	100	Yes	No	Yes	Yes	9	9
307	3x50	7x53	dopamine_on	0	100	Yes	No	Yes	Yes	9	9
308	3x51	5x57	dopamine_on	0	100	No	Yes	No	No	8	7
309	3x52	I2x53	dopamine_on	0	100	No	No	Yes	Yes	6	0
310	5x36	5x39	dopamine_on	0	100	No	No	Yes	Yes	7	8
311	5x461	Lig	dopamine_on	0	100	No	No	Yes	Yes	8	0
312	5x47	5x51	dopamine_on	0	100	No	Yes	No	No	9	7
313	5x47	6x44	dopamine_on	0	100	No	Yes	Yes	Yes	9	9
314	5x51	6x44	dopamine_on	0	100	No	No	Yes	Yes	7	9
315	5x58	6x40	dopamine_on	0	100	Yes	Yes	No	No	9	9
316	5x58	6x41	dopamine_on	0	100	Yes	Yes	No	No	9	8
317	5x62	6x34	dopamine_on	0	100	No	No	No	No	7	8
318	5x69	6x30	dopamine_on	0	100	No	No	No	Yes	6	9
319	6x36	7x56	dopamine_on	0	100	No	No	No	No	9	8
320	6x40	7x53	dopamine_on	0	100	No	No	Yes	Yes	9	9
321	6x48	7x45	dopamine_on	0	100	Yes	Yes	No	No	9	9
322	7x33	7x37	dopamine_on	0	100	No	No	No	No	6	5
323	7x38	7x42	dopamine_on	0	100	No	No	Yes	Yes	8	8
324	7x39	7x42	dopamine_on	0	100	Yes	Yes	Yes	Yes	8	8
325	7x45	7x49	dopamine_on	0	100	No	No	No	Yes	9	9
326	7x52	7x53	dopamine_on	0	100	No	No	Yes	Yes	8	9
327	7x54	8x50	dopamine_on	0	100	No	No	Yes	Yes	8	9
328	E1x51	E1x52	dopamine_on	0	100	No	No	No	Yes	4	7
329	3x43	7x49	dopamine_on	0	100	No	No	No	Yes	8	9
330	4x61	E2	dopamine_on	0	100	No	No	Yes	Yes	8	5
331	4x63	E2	dopamine_on	0	100	No	No	Yes	Yes	6	5
332	5x40	6x59	dopamine_on	0	100	No	No	No	No	7	6
333	5x54	6x44	dopamine_on	0	100	No	No	Yes	Yes	9	9
334	2x60	2x64	dopamine_on	0	100	No	Yes	Yes	Yes	8	7
335	5x39	E2	dopamine_on	0	100	Yes	Yes	Yes	Yes	8	5
336	5x44	6x55	dopamine_on	0	100	No	No	Yes	Yes	8	8
337	5x66	6x30	dopamine_on	0	100	No	No	No	Yes	6	9
338	7x55	8x51	dopamine_on	0	100	No	No	No	No	7	9
339	1x60	I1x49	dopamine_on	0	66.6667	No	Yes	No	No	8	7
340	3x29	E2x52	dopamine_on	0	62.2222	No	No	No	No	6	7
341	3x41	4x49	dopamine_on	0	46.6667	No	No	No	No	8	9
342	4x56	5x461	dopamine_on	0	46.6667	No	No	No	No	8	8
343	1x53	2x47	dopamine_on	0	48.8889	No	No	No	No	9	9
344	2x53	7x46	dopamine_on	0	56.6667	No	No	No	No	8	9
345	1x53	7x54	dopamine_on	0	44.4444	No	No	No	No	9	8
346	5x55	6x41	dopamine_on	0	51.1111	No	No	No	No	6	8
347	3x54	5x61	dopamine_on	0	40	No	No	No	No	8	9
348	4x59	4x60	dopamine_on	0	40	No	No	No	No	6	8
349	5x56	5x60	dopamine_on	0	60	No	No	No	No	5	7
350	6x43	7x48	dopamine_on	0	40	No	No	No	No	7	7
351	2x38	4x39	dopamine_on	0	44.4444	No	Yes	No	No	7	6
352	1x43	2x58	dopamine_on	0	46.6667	No	No	No	No	8	9
353	5x37	E3	dopamine_on	0	20	No	No	Yes	Yes	4	4
354	1x48	1x52	dopamine_on	0	37.7778	No	No	No	No	5	8
355	2x41	4x42	dopamine_on	0	38.8889	No	No	No	No	7	7
356	3x23	3x26	dopamine_on	0	20	No	No	No	No	4	6
357	2x38	I2x53	dopamine_on	0	26.6667	No	Yes	Yes	Yes	7	0
358	3x55	3x56	dopamine_on	0	24.4444	No	No	No	No	8	6
359	5x59	5x63	dopamine_on	0	26.6667	No	No	No	No	4	5
360	1x47	2x54	dopamine_on	0	4.44444	No	No	No	No	7	8
361	3x30	4x58	dopamine_on	0	40	No	No	No	No	8	0
362	3x48	4x45	dopamine_on	0	26.6667	No	No	No	No	7	8
363	2x48	2x52	dopamine_on	0	20	No	No	No	No	7	7
364	5x65	6x33	dopamine_on	0	8.88889	Yes	No	No	No	8	9
365	5x62	6x37	dopamine_on	0	21.1111	No	No	No	No	7	8
366	I2x52	I2x55	dopamine_on	0	40	No	Yes	No	No	0	0
367	1x31	7x32	dopamine_on	0	20	No	No	No	No	0	4
368	5x45	5x48	dopamine_on	0	8.88889	No	No	No	No	6	7
369	5x68	6x30	dopamine_on	0	20	No	No	No	Yes	8	9
370	4x40	I2	dopamine_on	0	20	No	No	No	No	6	0
371	1x42	7x43	dopamine_on	0	11.1111	No	No	No	No	7	6
372	5x51	5x52	dopamine_on	0	20	No	No	No	No	7	4
373	8x49	8x52	dopamine_on	0	20	Yes	No	No	No	7	6
374	5x69	6x29	dopamine_on	0	20	No	No	No	No	6	7
375	6x35	6x39	dopamine_on	0	16.6667	No	No	No	No	8	8
376	2x41	4x43	dopamine_on	0	20	No	No	No	No	7	5
377	I2x52	I2x56	dopamine_on	0	8.88889	No	Yes	No	No	0	0
378	1x38	1x39	dopamine_on	0	4.44444	No	No	Yes	No	5	7
379	1x59	1x60	dopamine_on	0	6.66667	No	No	No	Yes	7	8
380	8x52	8x55	dopamine_on	0	20	No	No	No	No	6	5
381	1x54	2x47	dopamine_on	0	0	No	No	No	No	7	9
382	I2x54	I2x55	dopamine_on	0	20	No	No	No	No	0	0
383	5x68	5x71	dopamine_on	0	2.22222	No	No	No	No	8	6
384	6x27	6x31	dopamine_on	0	16.6667	No	No	No	No	5	7
385	1x30	NT	dopamine_on	0	22.2222	No	No	No	No	0	0
386	1x32	1x35	dopamine_on	0	0	No	No	Yes	No	0	5
387	5x68	5x72	dopamine_on	0	20	No	No	No	No	8	0
388	4x40	4x44	dopamine_on	0	20	No	No	No	No	6	3
389	1x33	1x37	dopamine_on	0	0	No	No	No	No	7	6
390	7x36	7x40	dopamine_on	0	2.22222	No	No	No	No	6	8
391	1x40	1x44	dopamine_on	0	0	No	No	No	No	4	5
392	2x63	E1	dopamine_on	0	0	No	No	No	No	7	0
393	2x61	2x65	dopamine_on	0	0	No	No	No	No	8	6
394	1x32	NT	dopamine_on	0	2.22222	No	No	No	No	0	0
395	5x72	5x76	dopamine_on	0	6.66667	No	No	No	No	0	0
396	6x32	6x36	dopamine_on	0	0	No	No	No	No	9	9
397	4x55	4x59	dopamine_on	0	2.22222	No	No	No	No	5	6
398	6x28	6x31	dopamine_on	0	0	No	No	No	No	6	7
399	I2	I2x52	dopamine_on	0	6.66667	No	No	No	Yes	0	0
400	5x74	5x77	dopamine_on	0	0	No	No	No	No	0	0
401	1x52	8x58	dopamine_on	0	10	No	No	No	No	8	8
402	5x41	5x42	dopamine_on	0	6.66667	No	No	No	No	7	7
403	5x69	5x73	dopamine_on	0	6.66667	No	No	No	No	6	0
404	I2x57	I2x58	dopamine_on	0	13.3333	No	No	No	No	0	0
405	5x73	5x77	dopamine_on	0	0	No	No	No	No	0	0
406	I2x50	I2x51	dopamine_on	0	10	No	No	No	No	9	0
407	5x77	5x81	dopamine_on	0	2.22222	No	No	No	No	0	0
408	1x37	1x38	dopamine_on	0	0	No	No	No	No	6	5
409	6x37	6x38	dopamine_on	0	0	No	No	No	No	8	8
410	2x37	I1x52	dopamine_on	0	2.22222	No	No	No	No	8	0
411	8x55	CT	dopamine_on	0	2.22222	No	No	No	No	5	0
412	8x60	8x61	dopamine_on	0	2.22222	No	No	No	No	0	0
413	5x80	5x84	dopamine_on	0	0	No	No	No	No	0	0
414	4x37	4x38	dopamine_on	0	0	No	No	No	No	8	6
415	1x57	1x58	dopamine_on	0	0	No	No	No	No	8	6
416	8x55	8x61	dopamine_on	0	0	No	No	No	No	5	0
417	5x83	5x86	dopamine_on	0	0	No	No	No	No	0	0
418	5x74	5x75	dopamine_on	0	0	No	No	No	No	0	0
419	5x78	5x81	dopamine_on	0	0	No	No	No	No	0	0
420	5x76	5x80	dopamine_on	0	0	No	No	No	No	0	0

Orange: nodes, hubs and links specific of dopamine_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of dopamine_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	dopamine_off Avg Int. Strength	dopamine_on Avg Int. Strength	dopamine_off Num Of Links	dopamine_on Num Of Links	ConSurf
1	1x35	dopamine_off	50	0	6	3	5
2	1x39	dopamine_off	50	0	4	3	7
3	2x57	dopamine_off	0	31.1111	5	3	9
4	3x24	dopamine_off	33.3333	20	4	3	6
5	3x44	dopamine_off	0	0	4	2	7
6	3x49	dopamine_off	100	20	5	3	8
7	3x50	dopamine_off	100	0	8	3	9
8	4x50	dopamine_off	0	26.6667	4	3	9
9	5x65	dopamine_off	0	0	4	2	8
10	5x67	dopamine_off	0	0	4	1	6
11	7x30	dopamine_off	0	0	4	3	6
12	7x34	dopamine_off	66.6667	13.3333	4	2	5
13	8x49	dopamine_off	0	0	4	2	7
14	1x46	Shared	0	0	4	4	8
15	1x50	Shared	83.3333	53.3333	4	4	9
16	2x64	Shared	0	0	4	4	7
17	E1x50	Shared	100	95.5556	5	6	9
18	E2	Shared	100	100	8	10	5
19	5x39	Shared	0	77.7778	4	5	8
20	5x58	Shared	50	95.5556	4	5	9
21	6x44	Shared	100	88.8889	5	4	9
22	6x48	Shared	100	100	6	6	9
23	6x49	Shared	0	0	4	4	7
24	6x51	Shared	100	83.3333	6	5	8
25	6x52	Shared	33.3333	90	5	5	8
26	6x55	Shared	50	40	4	4	8
27	E3	Shared	83.3333	40	6	4	4
28	7x39	Shared	33.3333	55.5556	4	4	8
29	7x42	Shared	100	100	4	7	8
30	7x53	Shared	100	93.3333	5	6	9
31	8x50	Shared	100	77.7778	6	6	9
32	8x54	Shared	0	0	4	4	9
33	Lig	Shared	100	100	11	11	0
34	I2x53	Shared	50	93.3333	4	6	0
35	1x60	dopamine_on	0	0	3	5	8
36	2x38	dopamine_on	0	0	3	4	7
37	2x42	dopamine_on	0	60	2	4	8
38	2x46	dopamine_on	0	68.8889	2	4	9
39	2x50	dopamine_on	0	75.5556	2	5	9
40	2x60	dopamine_on	0	40	2	4	8
41	E1x52	dopamine_on	16.6667	20	3	4	7
42	3x51	dopamine_on	0	33.3333	3	4	8
43	I2x52	dopamine_on	0	0	1	4	0
44	5x47	dopamine_on	0	97.7778	3	5	9
45	6x30	dopamine_on	0	0	3	4	9
46	7x49	dopamine_on	0	48.8889	2	4	9

Orange: nodes, hubs and links specific of dopamine_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of dopamine_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	dopamine_off Recurrence	dopamine_on Recurrence	dopamine_off Hub1?	dopamine_on Hub1?	dopamine_off Hub2?	dopamine_on Hub2?	ConSurf1	ConSurf2
1	1x39	2x64	dopamine_off	10.3552	0	Yes	No	Yes	Yes	7	7
2	1x39	2x60	dopamine_off	27.827	0	Yes	No	No	Yes	7	8
3	1x42	2x57	dopamine_off	83.2097	0	No	No	Yes	No	7	9
4	1x42	1x46	dopamine_off	82.1784	4.01943	No	No	Yes	Yes	7	8
5	1x46	7x46	dopamine_off	77.9326	0	Yes	Yes	No	No	8	9
6	1x50	7x50	dopamine_off	70.038	4.62368	Yes	Yes	No	No	9	9
7	1x53	7x50	dopamine_off	66.4737	0	No	No	No	No	9	9
8	1x53	7x53	dopamine_off	65.2192	0	No	No	Yes	Yes	9	9
9	7x53	8x50	dopamine_off	51.4082	0	Yes	Yes	Yes	Yes	9	9
10	8x50	8x54	dopamine_off	18.2016	0.443629	Yes	Yes	Yes	Yes	9	9
11	1x57	8x50	dopamine_off	11.5856	6.88007	No	No	Yes	Yes	8	9
12	6x48	Lig	dopamine_off	82.7513	0	Yes	Yes	Yes	Yes	9	0
13	3x40	6x44	dopamine_off	88.903	0	No	No	Yes	Yes	9	9
14	3x40	5x50	dopamine_off	88.1491	0	No	No	No	No	9	9
15	3x41	5x50	dopamine_off	86.6051	6.97185	No	No	No	No	8	9
16	3x41	4x52	dopamine_off	17.5924	1.75157	No	No	No	No	8	7
17	4x52	4x55	dopamine_off	16.1269	0	No	No	No	No	7	5
18	4x51	4x55	dopamine_off	14.794	3.95059	No	No	No	No	5	5
19	4x47	4x51	dopamine_off	13.5517	1.97721	No	No	No	No	5	5
20	4x43	4x47	dopamine_off	12.454	0	No	No	No	No	5	5
21	4x39	4x43	dopamine_off	11.4891	0	No	No	No	No	6	5
22	3x41	3x44	dopamine_off	70.4843	0	No	No	Yes	No	8	7
23	3x44	5x54	dopamine_off	67.6618	0	Yes	No	No	No	7	9
24	3x50	6x37	dopamine_off	34.5938	0	Yes	No	No	No	9	8
25	3x49	3x50	dopamine_off	14.788	0	Yes	No	Yes	No	8	9
26	3x39	6x44	dopamine_off	16.2777	0	No	No	Yes	Yes	9	9
27	2x46	3x39	dopamine_off	14.7036	0	No	Yes	No	No	9	9
28	2x53	2x57	dopamine_off	10.5542	0	No	No	Yes	No	8	9
29	4x60	5x39	dopamine_off	49.9005	9.82484	No	No	Yes	Yes	8	8
30	4x60	E2	dopamine_off	48.8511	0	No	No	Yes	Yes	8	5
31	3x22	E2	dopamine_off	34.232	1.54123	No	No	Yes	Yes	3	5
32	3x22	3x25	dopamine_off	33.1283	0	No	No	No	No	3	9
33	3x25	E1x50	dopamine_off	29.9861	1.98103	No	No	Yes	Yes	9	9
34	E1x50	E1x52	dopamine_off	17.4296	9.80572	Yes	Yes	No	Yes	9	7
35	2x62	E1x52	dopamine_off	16.1812	3.95824	No	No	No	Yes	6	7
36	2x62	2x66	dopamine_off	11.5916	1.98103	No	No	No	No	6	5
37	3x33	Lig	dopamine_off	16.0666	7.54933	No	No	Yes	Yes	8	0
38	3x50	6x30	dopamine_off	12.5384	0	Yes	No	No	Yes	9	9
39	5x58	5x61	dopamine_off	27.9959	0	Yes	Yes	No	No	9	9
40	5x61	5x65	dopamine_off	11.3443	0	No	No	Yes	No	9	8
41	5x36	E2	dopamine_off	11.5856	0.0879608	No	No	Yes	Yes	7	5
42	6x55	Lig	dopamine_off	10.5362	5.86661	Yes	Yes	Yes	Yes	8	0
43	3x51	5x60	dopamine_off	13.0752	5.70981	No	Yes	No	No	8	7
44	5x60	5x63	dopamine_off	11.5192	0	No	No	No	No	7	5
45	7x49	7x53	dopamine_off	13.6361	0	No	Yes	Yes	Yes	9	9
46	6x40	7x49	dopamine_off	12.0258	0	No	No	No	Yes	9	9
47	6x40	7x52	dopamine_off	10.3371	0	No	No	No	No	9	8
48	7x30	E3	dopamine_off	13.9376	0	Yes	No	Yes	Yes	6	4
49	2x38	4x38	dopamine_off	12.5264	5.76717	No	Yes	No	No	7	6
50	2x60	7x42	Shared	29.0453	40.0145	No	Yes	Yes	Yes	8	8
51	2x57	7x42	Shared	88.0285	19.3667	Yes	No	Yes	Yes	9	8
52	1x39	7x39	Shared	12.7314	19.0952	Yes	No	Yes	Yes	7	8
53	2x50	7x46	Shared	76.841	20.579	No	Yes	No	No	9	9
54	1x50	2x50	Shared	75.7373	77.83	Yes	Yes	No	Yes	9	9
55	8x50	I1x50	Shared	13.0812	31.7194	Yes	Yes	No	No	9	9
56	7x42	Lig	Shared	100	88.2744	Yes	Yes	Yes	Yes	8	0
57	6x44	6x48	Shared	98.7636	55.4727	Yes	Yes	Yes	Yes	9	9
58	3x47	5x54	Shared	64.785	73.9521	No	No	No	No	9	9
59	3x47	5x58	Shared	62.843	69.8983	No	No	Yes	Yes	9	9
60	5x58	6x37	Shared	39.4307	58.8229	Yes	Yes	No	No	9	8
61	2x46	3x42	Shared	13.1174	55.4689	No	Yes	No	No	9	8
62	5x43	Lig	Shared	55.9315	36.412	No	No	Yes	Yes	9	0
63	5x39	5x43	Shared	55.1173	34.8134	Yes	Yes	No	No	8	9
64	3x51	5x61	Shared	16.151	13.6263	No	Yes	No	No	8	9
65	6x52	Lig	Shared	15.5539	81.6047	Yes	Yes	Yes	Yes	8	0
66	5x47	6x52	Shared	23.8948	37.8308	No	Yes	Yes	Yes	9	8
67	5x47	6x49	Shared	19.462	20.514	No	Yes	Yes	Yes	9	7
68	6x51	7x34	Shared	13.6783	12.8805	Yes	Yes	Yes	No	8	5
69	6x58	7x34	Shared	27.1274	11.7562	No	No	Yes	No	5	5
70	6x58	E3	Shared	24.2506	10.6241	No	No	Yes	Yes	5	4
71	7x39	7x42	dopamine_on	0	31.4326	Yes	Yes	Yes	Yes	8	8
72	1x46	2x57	dopamine_on	0	13.9437	Yes	Yes	Yes	No	8	9
73	3x36	Lig	dopamine_on	1.04336	55.618	No	No	Yes	Yes	8	0
74	3x36	6x48	dopamine_on	0.729751	56.0119	No	No	Yes	Yes	8	9
75	6x48	7x45	dopamine_on	0	100	Yes	Yes	No	No	9	9
76	7x45	7x49	dopamine_on	0	98.497	No	No	No	Yes	9	9
77	2x50	7x49	dopamine_on	0	70.7626	No	Yes	No	Yes	9	9
78	6x48	6x52	dopamine_on	9.83656	74.3919	Yes	Yes	Yes	Yes	9	8
79	1x50	2x47	dopamine_on	1.74899	67.5807	Yes	Yes	No	No	9	9
80	1x53	2x47	dopamine_on	0	63.4274	No	No	No	No	9	9
81	1x53	7x54	dopamine_on	0	61.3393	No	No	No	No	9	8
82	7x54	8x50	dopamine_on	0	47.6098	No	No	Yes	Yes	8	9
83	1x60	I1x50	dopamine_on	4.77052	15.5079	No	Yes	No	No	8	9
84	2x46	7x49	dopamine_on	0	33.3639	No	Yes	No	Yes	9	9
85	2x45	3x42	dopamine_on	9.90893	43.3532	No	No	No	No	9	8
86	2x45	4x46	dopamine_on	1.67662	37.1118	No	No	No	No	9	9
87	2x42	4x46	dopamine_on	0	35.5324	No	Yes	No	No	8	9
88	2x42	3x49	dopamine_on	0	29.3636	No	Yes	Yes	No	8	8
89	3x49	I2x53	dopamine_on	0.192992	26.3844	Yes	No	Yes	Yes	8	0
90	2x38	I2x53	dopamine_on	0	17.661	No	Yes	Yes	Yes	7	0
91	3x43	7x49	dopamine_on	0	38.6454	No	No	No	Yes	8	9
92	2x53	7x46	dopamine_on	0	18.3226	No	No	No	No	8	9
93	2x53	3x35	dopamine_on	8.97413	16.0586	No	No	No	No	8	7
94	2x52	3x35	dopamine_on	8.25041	13.7869	No	No	No	No	7	7
95	2x60	3x28	dopamine_on	0	27.8109	No	Yes	No	No	8	7
96	3x28	E1x50	dopamine_on	0	22.5027	No	No	Yes	Yes	7	9
97	5x39	E2	dopamine_on	0	12.9379	Yes	Yes	Yes	Yes	8	5
98	3x42	4x49	dopamine_on	1.67662	12.1233	No	No	No	No	8	9
99	3x41	4x49	dopamine_on	0	10.4138	No	No	No	No	8	9
100	3x43	7x53	dopamine_on	0	76.7554	No	No	Yes	Yes	8	9
101	5x54	6x44	dopamine_on	0	75.2677	No	No	Yes	Yes	9	9
102	3x50	5x58	dopamine_on	0	32.5417	Yes	No	Yes	Yes	9	9
103	5x47	6x44	dopamine_on	0	35.1002	No	Yes	Yes	Yes	9	9
104	3x47	5x57	dopamine_on	1.64646	55.4574	No	No	No	No	9	7
105	3x51	5x57	dopamine_on	0	52.7497	No	Yes	No	No	8	7
106	3x51	3x55	dopamine_on	1.64646	31.3791	No	Yes	No	No	8	8
107	3x55	3x56	dopamine_on	0	28.6026	No	No	No	No	8	6
108	3x56	I2x52	dopamine_on	1.30873	20.2272	No	No	No	Yes	6	0
109	5x58	6x40	dopamine_on	0	32.274	Yes	Yes	No	No	9	9
110	6x40	7x53	dopamine_on	0	32.1401	No	No	Yes	Yes	9	9
111	5x58	6x41	dopamine_on	0	16.0356	Yes	Yes	No	No	9	8
112	5x62	6x37	dopamine_on	0	53.7517	No	No	No	No	7	8
113	5x62	5x66	dopamine_on	1.64646	48.6576	No	No	No	No	7	6
114	5x66	6x30	dopamine_on	0	43.5559	No	No	No	Yes	6	9
115	5x69	6x30	dopamine_on	0	18.3379	No	No	No	Yes	6	9
116	7x52	7x53	dopamine_on	0	22.1661	No	No	Yes	Yes	8	9
117	6x39	7x52	dopamine_on	6.94168	16.0662	No	No	No	No	8	8
118	6x39	7x56	dopamine_on	5.22285	11.9856	No	No	No	No	8	8
119	6x49	6x50	dopamine_on	6.67632	15.8215	Yes	Yes	No	No	7	9
120	6x50	7x37	dopamine_on	3.35927	11.0601	No	No	No	No	9	5
121	7x54	8x54	dopamine_on	8.64845	11.6185	No	No	Yes	Yes	8	9
122	3x54	5x61	dopamine_on	0	10.7886	No	No	No	No	8	9
123	5x55	6x41	dopamine_on	0	10.7197	No	No	No	No	6	8
124	8x49	I1x50	dopamine_on	6.84518	14.372	Yes	No	No	No	7	9
125	5x68	6x30	dopamine_on	0	14.2191	No	No	No	Yes	8	9
126	8x49	8x52	dopamine_on	0	12.1004	Yes	No	No	No	7	6
127	1x35	2x64	dopamine_on	7.38194	17.4545	Yes	No	Yes	Yes	5	7
128	2x64	7x39	dopamine_on	0.024124	11.6414	Yes	Yes	Yes	Yes	7	8
129	I2	I2x52	dopamine_on	0	10.1729	No	No	No	Yes	0	0
130	5x69	5x73	dopamine_on	0	13.0526	No	No	No	No	6	0
131	3x50	7x53	dopamine_on	0	31.8151	Yes	No	Yes	Yes	9	9
132	5x73	5x77	dopamine_on	0	10.3832	No	No	No	No	0	0
133	2x60	2x64	dopamine_on	0	12.1807	No	Yes	Yes	Yes	8	7
134	2x46	2x50	dopamine_on	0	28.9391	No	Yes	No	Yes	9	9
135	2x46	3x43	dopamine_on	0	39.1464	No	Yes	No	No	9	8
136	6x51	6x52	dopamine_on	1.30873	12.8155	Yes	Yes	Yes	Yes	8	8

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
2x56	3x32	Shared	7.05667	6.68378	0	1	2	1
2x57	7x42	Shared	6.18667	7.75644	0	0	2	1
2x60	7x42	Shared	4.83833	6.94511	0	1	2	1
3x32	7x42	Shared	8.24167	8.807	1	1	1	1
3x32	Lig	Shared	19.3	15.008	1	1	1	0
3x33	4x57	Shared	4.30833	4.67611	0	0	1	2
3x33	4x61	dopamine_off	3.47667	0	0	0	1	2
3x33	Lig	Shared	5.98167	11.1441	0	0	1	0
3x36	6x48	Shared	5.875	4.26756	1	0	1	1
3x36	Lig	Shared	7.40833	6.00422	1	0	1	0
3x37	4x56	dopamine_off	4.18833	0	0	0	2	2
3x37	5x461	Shared	7.995	8.84511	0	0	2	1
3x40	6x44	dopamine_off	5.72	0	0	0	2	2
4x61	5x39	Shared	9.94333	4.44	0	4	2	2
E2x52	Lig	Shared	10.4283	4.59844	0	0	1	0
5x39	5x43	Shared	5.06333	11.3743	0	4	2	1
5x40	6x55	Shared	7.14833	7.28756	0	0	2	1
5x43	Lig	Shared	4.55333	6.76822	0	0	1	0
5x47	6x52	Shared	23.4	22.3854	0	1	2	1
6x44	6x48	Shared	12.8633	5.83544	0	1	2	1
6x44	7x45	dopamine_off	8.66	0	0	1	2	2
6x48	6x51	dopamine_off	5.34333	0	1	0	1	1
6x48	6x52	Shared	4.175	6.20289	1	0	1	1
6x48	7x41	Shared	11.26	6.25367	1	0	1	2
6x48	Lig	dopamine_off	10.15	0	1	0	1	0
6x51	6x52	Shared	5.54167	9.15789	1	1	1	1
6x51	6x55	Shared	11.31	9.14067	1	1	1	1
6x51	7x34	Shared	3.78333	3.18789	1	1	1	2
6x51	7x38	Shared	4.105	4.69889	1	1	1	1
6x51	Lig	Shared	11.5617	14.2882	1	1	1	0
6x52	Lig	Shared	8.62333	7.93622	1	1	1	0
6x55	7x34	dopamine_off	10.7067	0	1	1	1	2
7x34	7x38	dopamine_off	3.95333	0	1	0	2	1
7x38	Lig	Shared	4.74333	5.979	1	1	1	0
7x42	Lig	Shared	6.74	8.90333	1	1	1	0
6x55	Lig	Shared	6.355	6.97822	1	1	1	0
5x44	6x52	Shared	2.86	5.66378	0	0	2	1
2x56	7x42	dopamine_on	0	3.80633	0	1	2	1
2x60	7x39	dopamine_on	0	6.06811	0	1	2	2
3x40	6x48	dopamine_on	0	12.7369	0	0	2	1
5x461	Lig	dopamine_on	0	4.26989	0	0	1	0
5x47	6x44	dopamine_on	0	5.16911	0	1	2	2
6x48	7x45	dopamine_on	0	11.2623	1	0	1	2
7x38	7x42	dopamine_on	0	4.63411	1	1	1	1
7x39	7x42	dopamine_on	0	5.30744	3	1	2	1
5x44	6x55	dopamine_on	0	3.82422	0	0	2	1
3x29	E2x52	dopamine_on	0	3.54778	0	0	2	1
4x56	5x461	dopamine_on	0	3.51767	5	0	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	dopamine_off	d2_off d3_off
	dopamine_on	d2_on d1_on d3_on d4_on d5_on

Network Difference
Value	dopamine_off	dopamine_on
I_min	3.45	3.64822
Number of Linked Nodes	263	283
Number of Specific Nodes	2 (0.76%)	22 (7.77%)
Number of Shared Nodes	261 (99.24%)	261 (92.23%)
Number of Links	286	306
Number of Specific Links	114 (39.86%)	134 (43.79%)
Number of Shared Links	172 (60.14%)	172 (56.21%)
Number of Hubs	34	33
Number of Specific Hubs	13 (38.24%)	12 (36.36%)
Number of Shared Hubs	21 (61.76%)	21 (63.64%)
Average % Shared Neighbours (Jaccard)	44.40
Average % Shared Neighbours (Otsuka)	53.68
Average % Shared Neighbours (Overlap Coefficient)	63.02
Average % Shared Cliques (k3-6)	54.84
Graphlets Similarity	0.651375

Paths Difference
Value	dopamine_off	dopamine_on
Number Of Nodes in MetaPath	73	81
Specific Nodes in MetaPath	27 (36.99%)	35 (43.21%)
Shared Nodes in MetaPath	261 (99.24%)	261 (99.24%)
Number Of Links MetaPath	70	87
Specific Links in MetaPath	49 (70.00%)	66 (75.86%)
Shared Links in MetaPath	172 (60.14%)	172 (60.14%)
Number of Shortest Paths	38076	76247
Length Of Smallest Path	3	3
Average Path Length	15.4625	13.8288
Length of Longest Path	36	27
Minimum Path Strength	0.5275	0.329528
Average Path Strength	5.89999	6.06825
Maximum Path Strength	15.7392	16.5385
Minimum Path Correlation	0.701667	0.702222
Average Path Correlation	0.915263	0.90575
Maximum Path Correlation	0.99	0.99
Minimum % Of Corr. Nodes	3.125	4
Average % Of Corr. Nodes	39.6467	38.535
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	41.1041	43.3564
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download dopamine_off_on.zip<

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