psnGPCR

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Orange: nodes, hubs and links specific of dopamine_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of dopamine_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	dopamine_off Int. Strength	dopamine_on Int. Strength	dopamine_off Hub1?	dopamine_on Hub1?	dopamine_off Hub2?	dopamine_on Hub2?	ConSurf1	ConSurf2
1	1x35	7x39	dopamine_off	100	0	No	No	Yes	No	5	8
2	1x46	7x46	dopamine_off	100	0	Yes	Yes	No	No	8	9
3	1x53	7x50	dopamine_off	100	0	No	No	No	No	9	9
4	1x53	7x53	dopamine_off	100	0	No	No	Yes	Yes	9	9
5	2x40	I1x50	dopamine_off	100	0	No	No	Yes	Yes	9	9
6	2x38	3x49	dopamine_off	100	0	No	Yes	Yes	No	6	9
7	2x39	3x50	dopamine_off	100	0	No	No	Yes	No	8	9
8	2x42	3x46	dopamine_off	100	0	Yes	Yes	No	No	7	9
9	2x43	7x53	dopamine_off	100	0	No	No	Yes	Yes	8	9
10	2x46	3x39	dopamine_off	100	0	No	Yes	No	No	9	9
11	2x53	2x57	dopamine_off	100	0	No	No	No	No	8	8
12	2x60	Lig	dopamine_off	100	0	Yes	Yes	Yes	Yes	8	0
13	3x24	E1x50	dopamine_off	100	0	No	No	Yes	Yes	4	9
14	3x28	Lig	dopamine_off	100	0	No	No	Yes	Yes	7	0
15	3x29	E2x52	dopamine_off	100	0	No	No	No	No	7	7
16	3x37	3x41	dopamine_off	100	0	Yes	No	No	No	8	7
17	3x37	4x56	dopamine_off	100	0	Yes	No	No	No	8	7
18	3x39	6x44	dopamine_off	100	0	No	No	Yes	Yes	9	9
19	3x40	5x50	dopamine_off	100	0	No	No	No	No	9	9
20	3x44	5x54	dopamine_off	100	0	No	No	No	No	7	8
21	3x46	6x37	dopamine_off	100	0	No	No	No	No	9	8
22	3x49	3x50	dopamine_off	100	0	Yes	No	Yes	No	9	9
23	3x50	3x53	dopamine_off	100	0	Yes	No	No	No	9	8
24	3x50	6x30	dopamine_off	100	0	Yes	No	No	Yes	9	8
25	3x50	6x34	dopamine_off	100	0	Yes	No	No	No	9	8
26	3x54	5x65	dopamine_off	100	0	No	No	No	No	8	8
27	4x54	4x59	dopamine_off	100	0	No	No	No	No	6	6
28	4x56	5x42	dopamine_off	100	0	No	No	No	No	7	6
29	4x60	E2	dopamine_off	100	0	No	No	Yes	Yes	7	4
30	5x36	5x37	dopamine_off	100	0	No	No	No	No	6	4
31	5x39	5x42	dopamine_off	100	0	Yes	Yes	No	No	7	6
32	5x42	5x46	dopamine_off	100	0	No	No	No	No	6	4
33	5x58	5x61	dopamine_off	100	0	Yes	Yes	No	No	9	9
34	5x63	5x67	dopamine_off	100	0	No	No	No	No	5	5
35	5x65	6x31	dopamine_off	100	0	No	No	No	No	8	7
36	6x36	8x47	dopamine_off	100	0	No	No	No	No	8	9
37	6x39	7x56	dopamine_off	100	0	No	No	No	No	8	7
38	6x40	7x49	dopamine_off	100	0	No	No	No	Yes	8	9
39	6x40	7x52	dopamine_off	100	0	No	No	No	No	8	8
40	6x44	7x45	dopamine_off	100	0	Yes	Yes	No	No	9	9
41	6x48	6x51	dopamine_off	100	0	Yes	Yes	Yes	Yes	8	8
42	6x48	Lig	dopamine_off	100	0	Yes	Yes	Yes	Yes	8	0
43	6x55	7x34	dopamine_off	100	0	Yes	No	No	No	8	4
44	E3	E3	dopamine_off	100	0	Yes	Yes	Yes	Yes	4	4
45	7x49	7x53	dopamine_off	100	0	No	Yes	Yes	Yes	9	9
46	7x53	8x50	dopamine_off	100	0	Yes	Yes	Yes	Yes	9	9
47	7x54	8x54	dopamine_off	100	0	No	No	No	Yes	8	9
48	7x55	7x56	dopamine_off	100	0	No	No	No	No	6	7
49	8x47	8x49	dopamine_off	100	0	No	No	Yes	No	9	7
50	2x64	7x39	dopamine_off	100	0	No	No	Yes	No	6	8
51	8x51	8x55	dopamine_off	100	0	No	No	No	No	9	5
52	3x49	4x42	dopamine_off	100	0	Yes	No	No	No	9	7
53	3x23	3x26	dopamine_off	100	0	No	No	No	No	4	6
54	5x37	E3	dopamine_off	100	0	No	No	Yes	Yes	4	4
55	5x66	6x31	dopamine_off	100	0	No	No	No	No	6	7
56	5x68	6x25	dopamine_off	100	0	No	No	No	No	7	4
57	5x69	6x31	dopamine_off	100	0	No	No	No	No	5	7
58	6x28	6x32	dopamine_off	33.3333	0	No	No	No	No	5	8
59	4x62	4x63	dopamine_off	66.6667	0	No	No	No	No	7	5
60	7x43	7x48	dopamine_off	66.6667	0	No	No	No	No	5	7
61	3x49	4x41	dopamine_off	33.3333	0	Yes	No	No	No	9	7
62	7x39	7x43	dopamine_off	33.3333	0	Yes	No	No	No	8	5
63	6x32	6x35	dopamine_off	66.6667	0	No	No	No	No	8	7
64	6x56	6x60	dopamine_off	66.6667	0	No	No	No	No	6	4
65	3x34	3x35	dopamine_off	33.3333	0	No	No	No	No	7	5
66	3x46	5x58	dopamine_off	33.3333	0	No	No	Yes	Yes	9	9
67	6x59	6x60	dopamine_off	66.6667	0	No	No	No	No	6	4
68	6x49	6x50	dopamine_off	44.4444	0	No	No	No	No	7	9
69	5x58	6x38	dopamine_off	66.6667	0	Yes	Yes	No	No	9	6
70	1x47	2x51	dopamine_off	33.3333	0	No	No	No	No	6	8
71	6x57	E3	dopamine_off	33.3333	0	No	No	Yes	Yes	6	4
72	1x48	1x49	dopamine_off	33.3333	0	No	No	No	No	5	9
73	8x48	8x49	dopamine_off	66.6667	0	No	No	Yes	No	5	7
74	6x29	6x30	dopamine_off	33.3333	0	No	No	No	Yes	7	8
75	1x57	8x50	dopamine_off	0	0	No	No	Yes	Yes	8	9
76	6x27	6x29	dopamine_off	44.4444	0	No	No	No	No	5	7
77	2x62	E1x51	dopamine_off	44.4444	0	No	No	No	No	6	4
78	8x49	I1x49	dopamine_off	33.3333	0	Yes	No	No	No	7	6
79	7x30	E3	dopamine_off	66.6667	0	Yes	No	Yes	Yes	5	4
80	1x56	8x53	dopamine_off	0	0	No	No	No	No	9	8
81	6x25	6x30	dopamine_off	33.3333	0	No	No	No	Yes	4	8
82	5x69	6x28	dopamine_off	33.3333	0	No	No	No	No	5	5
83	6x27	I2x54	dopamine_off	33.3333	0	No	No	No	No	5	6
84	5x67	5x70	dopamine_off	33.3333	0	No	No	No	No	5	6
85	1x54	2x44	dopamine_off	11.1111	0	No	No	No	No	7	7
86	7x30	7x31	dopamine_off	0	0	Yes	No	No	No	5	2
87	3x26	4x64	dopamine_off	33.3333	0	No	No	No	No	6	5
88	3x50	6x33	dopamine_off	33.3333	0	Yes	No	No	No	9	8
89	6x26	I2x50	dopamine_off	11.1111	0	No	No	No	No	5	8
90	4x39	4x41	dopamine_off	33.3333	0	No	No	No	No	4	7
91	4x36	4x40	dopamine_off	33.3333	0	No	No	No	No	0	5
92	1x33	1x35	dopamine_off	33.3333	0	No	No	No	No	0	5
93	I2	I2x56	dopamine_off	33.3333	0	No	No	No	No	6	4
94	2x48	4x50	dopamine_off	22.2222	0	No	No	Yes	No	6	9
95	I2x51	I2x53	dopamine_off	33.3333	0	No	No	No	Yes	6	8
96	3x48	5x57	dopamine_off	0	0	No	No	No	No	6	7
97	3x27	4x62	dopamine_off	0	0	No	No	No	No	5	7
98	5x41	5x45	dopamine_off	22.2222	0	No	No	No	No	6	5
99	4x39	4x43	dopamine_off	33.3333	0	No	No	No	No	4	3
100	3x56	I2x51	dopamine_off	0	0	No	No	No	No	6	6
101	1x37	1x38	dopamine_off	33.3333	0	No	No	No	No	6	4
102	4x40	4x43	dopamine_off	33.3333	0	No	No	No	No	5	3
103	5x55	5x56	dopamine_off	0	0	No	No	No	No	5	4
104	1x37	1x41	dopamine_off	0	0	No	No	No	No	6	4
105	1x43	1x44	dopamine_off	0	0	No	No	No	No	7	4
106	5x52	5x56	dopamine_off	0	0	No	No	No	No	4	4
107	I2x55	I2x56	dopamine_off	0	0	No	No	No	No	5	4
108	8x55	8x59	dopamine_off	22.2222	0	No	No	No	No	5	4
109	4x52	4x55	dopamine_off	11.1111	0	No	No	No	No	5	5
110	1x34	1x35	dopamine_off	11.1111	0	No	No	No	No	0	5
111	4x46	4x47	dopamine_off	0	0	No	No	No	No	8	4
112	I2x56	I2x57	dopamine_off	0	0	No	No	No	No	4	6
113	4x34	4x38	dopamine_off	11.1111	0	No	No	No	No	0	8
114	1x54	1x58	dopamine_off	0	0	No	No	No	No	7	4
115	7x33	7x36	dopamine_off	0	0	No	No	No	No	5	5
116	6x29	I3	dopamine_off	0	0	No	No	No	No	7	0
117	4x35	4x39	dopamine_off	11.1111	0	No	No	No	No	0	4
118	1x39	7x39	Shared	100	100	No	No	Yes	No	7	8
119	1x42	1x46	Shared	100	52.7778	No	No	Yes	Yes	7	8
120	1x43	2x57	Shared	100	100	No	No	No	No	7	8
121	1x46	2x54	Shared	100	29.1667	Yes	Yes	No	No	8	8
122	1x49	7x50	Shared	100	55.5556	No	No	No	No	9	9
123	1x50	2x47	Shared	100	66.6667	Yes	Yes	No	No	9	9
124	1x50	2x50	Shared	100	100	Yes	Yes	No	Yes	9	9
125	1x50	2x51	Shared	100	75	Yes	Yes	No	No	9	8
126	1x50	7x50	Shared	100	100	Yes	Yes	No	No	9	9
127	1x52	8x54	Shared	100	100	No	No	No	Yes	7	9
128	1x57	2x44	Shared	100	100	No	No	No	No	8	7
129	1x60	I1x50	Shared	100	100	No	Yes	Yes	Yes	8	9
130	1x60	8x53	Shared	100	100	No	Yes	No	No	8	8
131	8x49	I1x50	Shared	100	58.3333	Yes	No	Yes	Yes	7	9
132	8x50	I1x50	Shared	100	100	Yes	Yes	Yes	Yes	9	9
133	2x41	I1x51	Shared	100	27.7778	No	No	No	No	5	8
134	2x37	2x40	Shared	100	100	No	No	No	No	7	9
135	2x38	4x42	Shared	100	25	No	Yes	No	No	6	7
136	2x39	3x49	Shared	100	100	No	No	Yes	No	8	9
137	2x40	8x50	Shared	100	100	No	No	Yes	Yes	9	9
138	2x42	4x45	Shared	100	58.3333	Yes	Yes	No	No	7	6
139	2x42	4x46	Shared	100	33.3333	Yes	Yes	No	No	7	8
140	2x45	3x42	Shared	100	100	No	No	No	No	9	9
141	2x45	4x46	Shared	100	100	No	No	No	No	9	8
142	2x45	4x50	Shared	100	100	No	No	Yes	No	9	9
143	2x46	3x42	Shared	100	100	No	Yes	No	No	9	9
144	2x46	3x43	Shared	100	100	No	Yes	No	Yes	9	8
145	2x50	7x46	Shared	100	100	No	Yes	No	No	9	9
146	2x52	3x35	Shared	100	100	No	No	No	No	6	5
147	2x55	2x551	Shared	100	33.3333	No	No	No	No	5	6
148	2x551	3x31	Shared	100	100	No	No	No	No	6	4
149	2x56	3x32	Shared	100	100	No	No	No	No	8	8
150	2x57	7x42	Shared	100	100	No	No	Yes	Yes	8	8
151	2x59	3x24	Shared	100	100	No	No	No	No	7	4
152	2x59	3x28	Shared	100	100	No	No	No	No	7	7
153	2x60	7x42	Shared	100	100	Yes	Yes	Yes	Yes	8	8
154	2x62	2x66	Shared	100	50	No	No	No	No	6	5
155	2x62	E1x52	Shared	100	70.8333	No	No	No	Yes	6	6
156	2x63	E1x50	Shared	100	45.8333	No	No	Yes	Yes	5	9
157	2x64	7x35	Shared	100	100	No	No	No	No	6	6
158	E1x49	E1x51	Shared	100	100	No	No	No	No	3	4
159	E1x50	E1x52	Shared	100	100	Yes	Yes	No	Yes	9	6
160	3x25	E1x50	Shared	100	100	No	No	Yes	Yes	9	9
161	E1x50	E2x50	Shared	100	100	Yes	Yes	No	No	9	9
162	3x24	E1x52	Shared	100	100	No	No	No	Yes	4	6
163	3x21	3x23	Shared	100	25	No	No	No	No	7	4
164	3x22	E2	Shared	100	25	No	No	Yes	Yes	3	4
165	3x25	E2x50	Shared	100	100	No	No	No	No	9	9
166	3x26	E2	Shared	100	100	No	No	Yes	Yes	6	4
167	3x30	4x61	Shared	100	100	No	No	No	Yes	7	7
168	3x30	4x62	Shared	100	100	No	No	No	No	7	7
169	3x32	7x42	Shared	100	100	No	No	Yes	Yes	8	8
170	3x32	Lig	Shared	100	100	No	No	Yes	Yes	8	0
171	3x33	4x57	Shared	100	100	No	No	No	No	8	8
172	3x33	Lig	Shared	100	100	No	No	Yes	Yes	8	0
173	3x34	4x57	Shared	100	100	No	No	No	No	7	8
174	3x36	6x48	Shared	100	100	No	No	Yes	Yes	7	8
175	3x36	Lig	Shared	100	100	No	No	Yes	Yes	7	0
176	3x37	4x53	Shared	100	41.6667	Yes	No	No	No	8	8
177	3x37	5x461	Shared	100	100	Yes	No	No	No	8	8
178	3x38	4x50	Shared	100	100	No	No	Yes	No	8	9
179	3x40	6x44	Shared	100	100	No	No	Yes	Yes	9	9
180	3x41	4x52	Shared	100	100	No	No	No	No	7	5
181	3x41	5x50	Shared	100	34.7222	No	No	No	No	7	9
182	3x42	4x49	Shared	100	100	No	No	No	No	9	7
183	3x43	6x44	Shared	100	100	No	Yes	Yes	Yes	8	9
184	3x47	5x54	Shared	100	100	No	No	No	No	9	8
185	3x47	5x57	Shared	100	100	No	No	No	No	9	7
186	3x47	5x58	Shared	100	100	No	No	Yes	Yes	9	9
187	3x49	I2x53	Shared	100	100	Yes	No	No	Yes	9	8
188	3x51	3x55	Shared	100	100	No	Yes	No	No	9	7
189	3x51	5x61	Shared	100	100	No	Yes	No	No	9	9
190	4x56	5x46	Shared	100	27.7778	No	No	No	No	7	4
191	4x60	5x39	Shared	100	100	No	No	Yes	Yes	7	7
192	4x61	5x39	Shared	100	100	No	Yes	Yes	Yes	7	7
193	E2	E2	Shared	100	100	Yes	Yes	Yes	Yes	4	4
194	5x36	E2	Shared	100	100	No	No	Yes	Yes	6	4
195	E2	E2x51	Shared	100	100	Yes	Yes	No	No	4	4
196	E2x52	Lig	Shared	100	100	No	No	Yes	Yes	7	0
197	5x39	5x43	Shared	100	100	Yes	Yes	No	No	7	8
198	5x40	6x55	Shared	100	100	No	No	Yes	No	7	8
199	5x43	Lig	Shared	100	100	No	No	Yes	Yes	8	0
200	5x47	5x48	Shared	100	100	Yes	Yes	No	No	9	6
201	5x47	6x49	Shared	100	100	Yes	Yes	No	No	9	7
202	5x47	6x52	Shared	100	100	Yes	Yes	Yes	Yes	9	7
203	5x51	6x45	Shared	100	50	No	Yes	No	No	6	5
204	5x58	6x41	Shared	100	100	Yes	Yes	No	No	9	8
205	5x62	5x66	Shared	100	100	No	Yes	No	No	6	6
206	6x39	7x52	Shared	100	25	No	No	No	No	8	8
207	6x44	6x48	Shared	100	100	Yes	Yes	Yes	Yes	9	8
208	6x47	7x45	Shared	100	100	No	No	No	No	8	9
209	6x48	6x52	Shared	100	100	Yes	Yes	Yes	Yes	8	7
210	6x48	7x41	Shared	100	100	Yes	Yes	No	No	8	7
211	6x48	7x45	Shared	100	100	Yes	Yes	No	No	8	9
212	6x49	6x53	Shared	100	100	No	No	No	No	7	6
213	6x50	7x37	Shared	100	100	No	No	No	No	9	6
214	6x50	7x40	Shared	100	8.33333	No	No	No	No	9	8
215	6x51	6x52	Shared	100	100	Yes	Yes	Yes	Yes	8	7
216	6x51	6x55	Shared	100	100	Yes	Yes	Yes	No	8	8
217	6x51	7x38	Shared	100	100	Yes	Yes	No	No	8	6
218	6x51	Lig	Shared	100	100	Yes	Yes	Yes	Yes	8	0
219	6x52	Lig	Shared	100	100	Yes	Yes	Yes	Yes	7	0
220	6x54	7x37	Shared	100	100	No	No	No	No	6	6
221	6x55	Lig	Shared	100	100	Yes	No	Yes	Yes	8	0
222	6x58	E3	Shared	100	100	No	No	Yes	Yes	5	4
223	6x61	E3	Shared	100	100	No	No	Yes	Yes	5	4
224	7x30	7x33	Shared	100	30.5556	Yes	No	No	No	5	5
225	7x38	Lig	Shared	100	100	No	No	Yes	Yes	6	0
226	7x42	Lig	Shared	100	100	Yes	Yes	Yes	Yes	8	0
227	8x47	8x50	Shared	100	100	No	No	Yes	Yes	9	9
228	8x48	8x52	Shared	100	25	No	No	No	No	5	6
229	8x50	8x54	Shared	100	100	Yes	Yes	No	Yes	9	9
230	I1x48	I1x51	Shared	100	100	No	No	No	No	7	8
231	2x42	3x49	Shared	100	100	Yes	Yes	Yes	No	7	9
232	2x60	7x39	Shared	100	100	Yes	Yes	Yes	No	8	8
233	3x52	4x41	Shared	100	100	No	No	No	No	5	7
234	8x52	8x55	Shared	100	2.77778	No	No	No	No	6	5
235	2x60	2x64	Shared	100	33.3333	Yes	Yes	No	No	8	6
236	5x49	5x50	Shared	33.3333	54.1667	No	No	No	No	7	9
237	I2x53	I2x57	Shared	33.3333	100	No	Yes	No	No	8	6
238	5x62	6x34	Shared	33.3333	100	No	Yes	No	No	6	8
239	5x47	5x51	Shared	33.3333	100	Yes	Yes	No	Yes	9	6
240	5x41	6x60	Shared	66.6667	30.5556	No	No	No	No	6	4
241	5x44	6x52	Shared	66.6667	100	No	No	Yes	Yes	8	7
242	1x39	2x61	Shared	66.6667	100	No	No	No	No	7	6
243	2x50	3x39	Shared	33.3333	100	No	Yes	No	No	9	9
244	5x48	6x56	Shared	66.6667	100	No	No	No	No	6	6
245	5x66	5x70	Shared	33.3333	100	No	No	No	No	6	6
246	1x51	2x51	Shared	0	0	No	No	No	No	5	8
247	3x51	5x60	Shared	11.1111	100	No	Yes	No	No	9	6
248	3x54	5x64	Shared	33.3333	100	No	No	No	No	8	7
249	3x34	4x54	Shared	44.4444	100	No	No	No	No	7	6
250	5x36	5x38	Shared	55.5556	41.6667	No	No	No	No	6	4
251	2x52	2x551	Shared	33.3333	33.3333	No	No	No	No	6	6
252	1x55	8x57	Shared	44.4444	43.0556	No	No	No	No	5	7
253	8x52	8x56	Shared	33.3333	27.7778	No	No	No	No	6	6
254	5x67	5x71	Shared	33.3333	25	No	No	No	No	5	4
255	2x42	3x45	Shared	22.2222	100	Yes	Yes	No	No	7	7
256	2x41	4x42	Shared	33.3333	51.3889	No	No	No	No	5	7
257	2x49	4x50	Shared	0	50	No	No	Yes	No	8	9
258	1x59	1x60	Shared	33.3333	8.33333	No	No	No	Yes	5	8
259	6x43	7x52	Shared	22.2222	48.6111	No	No	No	No	6	8
260	3x44	5x53	Shared	11.1111	100	No	No	No	No	7	7
261	1x46	7x47	Shared	22.2222	100	Yes	Yes	No	No	8	6
262	1x59	8x57	Shared	33.3333	100	No	No	No	No	5	7
263	1x45	7x47	Shared	11.1111	23.6111	No	No	No	No	4	6
264	3x56	I2x50	Shared	11.1111	0	No	No	No	No	6	8
265	7x30	7x32	Shared	44.4444	30.5556	Yes	No	No	No	5	1
266	1x43	2x58	Shared	0	30.5556	No	No	No	No	7	9
267	5x51	5x55	Shared	33.3333	27.7778	No	Yes	No	No	6	5
268	5x55	5x59	Shared	33.3333	12.5	No	No	No	No	5	3
269	2x67	E1	Shared	0	0	No	No	No	No	4	5
270	7x51	7x55	Shared	0	75	No	No	No	No	6	6
271	6x41	6x42	Shared	0	2.77778	No	No	No	No	8	6
272	2x38	4x38	Shared	11.1111	50	No	Yes	No	No	6	8
273	2x63	E1	Shared	0	0	No	No	No	No	5	5
274	4x34	4x37	Shared	33.3333	25	No	No	No	No	0	0
275	1x36	2x65	Shared	0	2.77778	No	No	No	No	7	5
276	1x40	2x61	Shared	11.1111	8.33333	No	No	No	No	3	6
277	2x61	2x65	Shared	0	0	No	No	No	No	6	5
278	8x58	8x59	Shared	11.1111	0	No	No	No	No	7	4
279	4x44	4x48	Shared	22.2222	0	No	No	No	No	3	3
280	1x38	1x39	Shared	0	5.55556	No	No	No	No	4	7
281	4x47	4x51	Shared	0	0	No	No	No	No	4	5
282	4x51	4x55	Shared	0	0	No	No	No	No	5	5
283	3x56	I2x52	Shared	0	100	No	No	No	Yes	6	5
284	6x46	6x47	Shared	0	0	No	No	No	No	4	8
285	1x46	2x57	dopamine_on	0	100	Yes	Yes	No	No	8	8
286	1x53	7x54	dopamine_on	0	100	No	No	No	No	9	8
287	2x39	I2x53	dopamine_on	0	100	No	No	No	Yes	8	8
288	2x46	2x50	dopamine_on	0	100	No	Yes	No	Yes	9	9
289	2x46	7x49	dopamine_on	0	100	No	Yes	No	Yes	9	9
290	2x50	7x49	dopamine_on	0	100	No	Yes	No	Yes	9	9
291	2x53	3x35	dopamine_on	0	100	No	No	No	No	8	5
292	2x53	7x46	dopamine_on	0	100	No	No	No	No	8	9
293	2x56	7x42	dopamine_on	0	100	No	No	Yes	Yes	8	8
294	2x60	3x28	dopamine_on	0	100	Yes	Yes	No	No	8	7
295	3x28	E1x50	dopamine_on	0	100	No	No	Yes	Yes	7	9
296	E1x51	E1x52	dopamine_on	0	100	No	No	No	Yes	4	6
297	3x27	3x31	dopamine_on	0	100	No	No	No	No	5	4
298	3x40	6x48	dopamine_on	0	100	No	No	Yes	Yes	9	8
299	3x41	4x49	dopamine_on	0	100	No	No	No	No	7	7
300	3x43	7x49	dopamine_on	0	100	No	Yes	No	Yes	8	9
301	3x43	7x53	dopamine_on	0	100	No	Yes	Yes	Yes	8	9
302	3x44	5x50	dopamine_on	0	100	No	No	No	No	7	9
303	3x46	3x50	dopamine_on	0	100	No	No	Yes	No	9	9
304	3x46	7x53	dopamine_on	0	100	No	No	Yes	Yes	9	9
305	3x50	5x58	dopamine_on	0	100	Yes	No	Yes	Yes	9	9
306	3x50	7x53	dopamine_on	0	100	Yes	No	Yes	Yes	9	9
307	3x51	5x57	dopamine_on	0	100	No	Yes	No	No	9	7
308	3x52	I2x53	dopamine_on	0	100	No	No	No	Yes	5	8
309	3x53	I2x53	dopamine_on	0	100	No	No	No	Yes	8	8
310	4x61	E2	dopamine_on	0	100	No	Yes	Yes	Yes	7	4
311	4x63	E2	dopamine_on	0	100	No	No	Yes	Yes	5	4
312	5x39	E2	dopamine_on	0	100	Yes	Yes	Yes	Yes	7	4
313	5x36	5x39	dopamine_on	0	100	No	No	Yes	Yes	6	7
314	5x37	6x60	dopamine_on	0	100	No	No	No	No	4	4
315	5x40	6x59	dopamine_on	0	100	No	No	No	No	7	6
316	5x461	Lig	dopamine_on	0	100	No	No	Yes	Yes	8	0
317	5x47	6x44	dopamine_on	0	100	Yes	Yes	Yes	Yes	9	9
318	5x51	6x44	dopamine_on	0	100	No	Yes	Yes	Yes	6	9
319	5x54	6x44	dopamine_on	0	100	No	No	Yes	Yes	8	9
320	5x58	6x37	dopamine_on	0	100	Yes	Yes	No	No	9	8
321	5x58	6x40	dopamine_on	0	100	Yes	Yes	No	No	9	8
322	5x69	6x30	dopamine_on	0	100	No	No	No	Yes	5	8
323	6x36	7x56	dopamine_on	0	100	No	No	No	No	8	7
324	6x40	7x53	dopamine_on	0	100	No	No	Yes	Yes	8	9
325	6x51	7x34	dopamine_on	0	100	Yes	Yes	No	No	8	4
326	6x58	7x34	dopamine_on	0	100	No	No	No	No	5	4
327	7x33	7x37	dopamine_on	0	100	No	No	No	No	5	6
328	7x38	7x42	dopamine_on	0	100	No	No	Yes	Yes	6	8
329	7x45	7x49	dopamine_on	0	100	No	No	No	Yes	9	9
330	7x52	7x53	dopamine_on	0	100	No	No	Yes	Yes	8	9
331	7x54	8x50	dopamine_on	0	100	No	No	Yes	Yes	8	9
332	5x66	6x30	dopamine_on	0	100	No	No	No	Yes	6	8
333	7x39	7x42	dopamine_on	0	100	Yes	No	Yes	Yes	8	8
334	I1x49	I1x50	dopamine_on	0	100	No	No	Yes	Yes	6	9
335	7x55	8x51	dopamine_on	0	100	No	No	No	No	6	9
336	2x38	4x39	dopamine_on	0	55.5556	No	Yes	No	No	6	4
337	5x56	5x60	dopamine_on	0	75	No	No	No	No	4	6
338	3x29	4x61	dopamine_on	0	55.5556	No	No	No	Yes	7	7
339	4x64	E2	dopamine_on	0	36.1111	No	No	Yes	Yes	5	4
340	1x60	8x56	dopamine_on	0	58.3333	No	Yes	No	No	8	6
341	1x48	1x52	dopamine_on	0	47.2222	No	No	No	No	5	7
342	4x59	4x60	dopamine_on	0	50	No	No	No	No	6	7
343	6x43	7x48	dopamine_on	0	50	No	No	No	No	6	7
344	4x56	5x461	dopamine_on	0	33.3333	No	No	No	No	7	8
345	3x54	5x61	dopamine_on	0	50	No	No	No	No	8	9
346	2x39	2x40	dopamine_on	0	43.0556	No	No	No	No	8	9
347	6x54	E3	dopamine_on	0	25	No	No	Yes	Yes	6	4
348	2x38	I2x53	dopamine_on	0	30.5556	No	Yes	No	Yes	6	8
349	3x30	4x58	dopamine_on	0	50	No	No	No	No	7	0
350	2x48	2x52	dopamine_on	0	25	No	No	No	No	6	6
351	1x56	8x54	dopamine_on	0	11.1111	No	No	No	Yes	9	9
352	3x55	3x56	dopamine_on	0	33.3333	No	No	No	No	7	6
353	5x45	5x48	dopamine_on	0	25	No	No	No	No	5	6
354	I2x52	I2x55	dopamine_on	0	50	No	Yes	No	No	5	5
355	5x68	6x30	dopamine_on	0	25	No	No	No	Yes	7	8
356	4x40	I2	dopamine_on	0	25	No	No	No	No	5	6
357	5x37	6x59	dopamine_on	0	45.8333	No	No	No	No	4	6
358	1x42	7x43	dopamine_on	0	13.8889	No	No	No	No	7	5
359	5x62	6x37	dopamine_on	0	37.5	No	Yes	No	No	6	8
360	5x65	6x33	dopamine_on	0	11.1111	No	No	No	No	8	8
361	1x57	I1x51	dopamine_on	0	30.5556	No	No	No	No	8	8
362	6x53	6x57	dopamine_on	0	25	No	No	No	No	6	6
363	6x35	6x39	dopamine_on	0	23.6111	No	No	No	No	7	8
364	1x47	2x54	dopamine_on	0	2.77778	No	No	No	No	6	8
365	6x27	6x30	dopamine_on	0	30.5556	No	No	No	Yes	5	8
366	7x31	7x32	dopamine_on	0	27.7778	No	No	No	No	2	1
367	5x69	6x29	dopamine_on	0	25	No	No	No	No	5	7
368	2x41	4x43	dopamine_on	0	25	No	No	No	No	5	3
369	7x55	8x54	dopamine_on	0	30.5556	No	No	No	Yes	6	9
370	3x48	4x45	dopamine_on	0	8.33333	No	No	No	No	6	6
371	I2x52	I2x56	dopamine_on	0	11.1111	No	Yes	No	No	5	4
372	2x43	8x50	dopamine_on	0	25	No	No	Yes	Yes	8	9
373	5x62	6x33	dopamine_on	0	5.55556	No	Yes	No	No	6	8
374	5x68	5x71	dopamine_on	0	2.77778	No	No	No	No	7	4
375	1x35	2x64	dopamine_on	0	12.5	No	No	No	No	5	6
376	6x27	6x31	dopamine_on	0	20.8333	No	No	No	No	5	7
377	6x28	6x31	dopamine_on	0	2.77778	No	No	No	No	5	7
378	1x30	NT	dopamine_on	0	27.7778	No	No	No	No	0	0
379	5x59	5x63	dopamine_on	0	11.1111	No	No	No	No	3	5
380	1x33	1x37	dopamine_on	0	0	No	No	No	No	0	6
381	1x40	1x44	dopamine_on	0	2.77778	No	No	No	No	3	4
382	I2x54	I2x55	dopamine_on	0	25	No	No	No	No	6	5
383	5x51	5x52	dopamine_on	0	0	No	Yes	No	No	6	4
384	4x40	4x44	dopamine_on	0	25	No	No	No	No	5	3
385	1x54	2x48	dopamine_on	0	0	No	No	No	No	7	6
386	6x36	6x40	dopamine_on	0	0	No	No	No	No	8	8
387	7x36	7x40	dopamine_on	0	2.77778	No	No	No	No	5	8
388	5x72	6x29	dopamine_on	0	25	No	No	No	No	0	7
389	1x32	NT	dopamine_on	0	2.77778	No	No	No	No	0	0
390	1x34	1x38	dopamine_on	0	11.1111	No	No	No	No	0	4
391	I2	I2x52	dopamine_on	0	8.33333	No	No	No	Yes	6	5
392	5x72	5x76	dopamine_on	0	5.55556	No	No	No	No	0	0
393	5x41	5x42	dopamine_on	0	8.33333	No	No	No	No	6	6
394	5x74	5x77	dopamine_on	0	0	No	No	No	No	0	0
395	1x32	1x35	dopamine_on	0	0	No	No	No	No	0	5
396	4x55	4x59	dopamine_on	0	0	No	No	No	No	5	6
397	1x52	8x58	dopamine_on	0	12.5	No	No	No	No	7	7
398	5x69	5x73	dopamine_on	0	8.33333	No	No	No	No	5	0
399	I2x57	I2x58	dopamine_on	0	16.6667	No	No	No	No	6	3
400	5x73	5x77	dopamine_on	0	2.77778	No	No	No	No	0	0
401	5x77	5x81	dopamine_on	0	2.77778	No	No	No	No	0	0
402	6x32	6x36	dopamine_on	0	0	No	No	No	No	8	8
403	I2x50	I2x51	dopamine_on	0	12.5	No	No	No	No	8	6
404	3x22	3x23	dopamine_on	0	12.5	No	No	No	No	3	4
405	6x26	6x27	dopamine_on	0	5.55556	No	No	No	No	5	5
406	2x37	I1x52	dopamine_on	0	2.77778	No	No	No	No	7	0
407	8x55	CT	dopamine_on	0	2.77778	No	No	No	No	5	9
408	1x41	1x45	dopamine_on	0	0	No	No	No	No	4	4
409	1x33	1x36	dopamine_on	0	0	No	No	No	No	0	7
410	8x60	8x61	dopamine_on	0	2.77778	No	No	No	No	0	0
411	5x85	6x29	dopamine_on	0	2.77778	No	No	No	No	0	7
412	5x81	5x84	dopamine_on	0	2.77778	No	No	No	No	0	0
413	5x80	5x84	dopamine_on	0	0	No	No	No	No	0	0
414	4x37	4x38	dopamine_on	0	0	No	No	No	No	0	8
415	1x31	1x35	dopamine_on	0	0	No	No	No	No	0	5
416	1x57	1x58	dopamine_on	0	0	No	No	No	No	8	4
417	4x36	4x37	dopamine_on	0	0	No	No	No	No	0	0
418	8x55	8x61	dopamine_on	0	0	No	No	No	No	5	0
419	5x83	5x86	dopamine_on	0	0	No	No	No	No	0	0
420	6x62	E3	dopamine_on	0	0	No	No	Yes	Yes	0	4
421	6x38	6x39	dopamine_on	0	0	No	No	No	No	6	8
422	5x74	5x75	dopamine_on	0	0	No	No	No	No	0	0
423	5x80	5x83	dopamine_on	0	0	No	No	No	No	0	0
424	5x78	5x81	dopamine_on	0	0	No	No	No	No	0	0
425	1x29	1x31	dopamine_on	0	0	No	No	No	No	0	0

Orange: nodes, hubs and links specific of dopamine_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of dopamine_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	dopamine_off Avg Int. Strength	dopamine_on Avg Int. Strength	dopamine_off Num Of Links	dopamine_on Num Of Links	ConSurf
1	3x37	dopamine_off	33.3333	0	4	2	8
2	3x49	dopamine_off	66.6667	25	7	3	9
3	3x50	dopamine_off	100	0	6	3	9
4	4x50	dopamine_off	0	33.3333	4	3	9
5	6x55	dopamine_off	33.3333	25	4	3	8
6	7x30	dopamine_off	0	0	4	2	5
7	7x39	dopamine_off	22.2222	69.4444	5	3	8
8	8x49	dopamine_off	0	0	4	1	7
9	1x46	Shared	0	0	4	4	8
10	1x50	Shared	88.8889	41.6667	4	4	9
11	I1x50	Shared	66.6667	25	4	4	9
12	2x42	Shared	33.3333	50	5	4	7
13	2x60	Shared	33.3333	38.8889	4	4	8
14	E1x50	Shared	100	94.4444	5	5	9
15	E2	Shared	100	100	7	10	4
16	5x39	Shared	33.3333	72.2222	4	5	7
17	5x47	Shared	33.3333	97.2222	4	5	9
18	5x58	Shared	66.6667	91.6667	5	5	9
19	6x44	Shared	100	86.1111	5	6	9
20	6x48	Shared	100	100	7	6	8
21	6x51	Shared	100	79.1667	5	5	8
22	6x52	Shared	55.5556	87.5	5	5	7
23	E3	Shared	88.8889	61.1111	7	4	4
24	7x42	Shared	100	100	4	7	8
25	7x53	Shared	100	91.6667	4	5	9
26	8x50	Shared	88.8889	69.4444	6	6	9
27	Lig	Shared	100	100	13	11	0
28	1x60	dopamine_on	0	0	3	4	8
29	2x38	dopamine_on	0	0	3	4	6
30	2x46	dopamine_on	0	63.8889	3	4	9
31	2x50	dopamine_on	0	72.2222	3	5	9
32	E1x52	dopamine_on	0	33.3333	3	4	6
33	3x43	dopamine_on	0	16.6667	2	4	8
34	3x51	dopamine_on	0	16.6667	3	4	9
35	I2x52	dopamine_on	0	0	1	4	5
36	I2x53	dopamine_on	33.3333	91.6667	3	6	8
37	4x61	dopamine_on	22.2222	0	2	4	7
38	5x51	dopamine_on	0	16.6667	3	5	6
39	5x62	dopamine_on	0	8.33333	2	4	6
40	6x30	dopamine_on	0	0	3	4	8
41	7x49	dopamine_on	0	36.1111	2	4	9
42	8x54	dopamine_on	33.3333	0	3	4	9

Orange: nodes, hubs and links specific of dopamine_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of dopamine_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	dopamine_off Recurrence	dopamine_on Recurrence	dopamine_off Hub1?	dopamine_on Hub1?	dopamine_off Hub2?	dopamine_on Hub2?	ConSurf1	ConSurf2
1	2x60	7x39	dopamine_off	17.8319	0.524969	Yes	Yes	Yes	No	8	8
2	2x60	Lig	dopamine_off	20.6723	0	Yes	Yes	Yes	Yes	8	0
3	6x48	Lig	dopamine_off	74.0986	0	Yes	Yes	Yes	Yes	8	0
4	3x39	6x44	dopamine_off	68.5114	0	No	No	Yes	Yes	9	9
5	2x50	3x39	dopamine_off	53.4142	1.17567	No	Yes	No	No	9	9
6	1x50	2x50	dopamine_off	48.9135	6.99885	Yes	Yes	No	Yes	9	9
7	1x50	7x50	dopamine_off	45.4545	2.34913	Yes	Yes	No	No	9	9
8	1x53	7x50	dopamine_off	43.2815	0	No	No	No	No	9	9
9	1x53	7x53	dopamine_off	42.4961	0	No	No	Yes	Yes	9	9
10	7x53	8x50	dopamine_off	34.5691	0	Yes	Yes	Yes	Yes	9	9
11	8x47	8x50	dopamine_off	10.4297	1.63005	No	No	Yes	Yes	9	9
12	2x46	3x39	dopamine_off	56.4214	0	No	Yes	No	No	9	9
13	3x49	3x50	dopamine_off	36.1561	0	Yes	No	Yes	No	9	9
14	2x42	3x46	dopamine_off	25.7793	0	Yes	Yes	No	No	7	9
15	3x33	Lig	dopamine_off	13.7829	6.22022	No	No	Yes	Yes	8	0
16	3x33	4x57	dopamine_off	12.558	4.86148	No	No	No	No	8	8
17	3x34	4x57	dopamine_off	11.1948	3.24466	No	No	No	No	7	8
18	3x28	Lig	dopamine_off	18.1859	0	No	No	Yes	Yes	7	0
19	2x59	3x28	dopamine_off	17.2296	3.27113	No	No	No	No	7	7
20	2x59	3x24	dopamine_off	16.2367	1.64108	No	No	No	No	7	4
21	4x60	5x39	dopamine_off	29.7713	8.08188	No	No	Yes	Yes	7	7
22	4x60	E2	dopamine_off	28.5383	0	No	No	Yes	Yes	7	4
23	5x39	5x42	dopamine_off	10.8733	0	Yes	Yes	No	No	7	6
24	3x37	4x56	dopamine_off	10.4623	0	Yes	No	No	No	8	7
25	3x41	4x52	dopamine_off	11.7401	1.63005	No	No	No	No	7	5
26	3x46	5x58	dopamine_off	22.6133	0	No	No	Yes	Yes	9	9
27	3x50	6x34	dopamine_off	23.0121	0	Yes	No	No	No	9	8
28	5x62	6x34	dopamine_off	21.8239	1.40286	No	Yes	No	No	6	8
29	5x66	6x31	dopamine_off	12.9283	0	No	No	No	No	6	7
30	5x36	E2	dopamine_off	18.6946	0.0551438	No	No	Yes	Yes	6	4
31	5x36	5x37	dopamine_off	15.4309	0	No	No	No	No	6	4
32	5x37	E3	dopamine_off	13.7788	0	No	No	Yes	Yes	4	4
33	8x48	8x49	dopamine_off	13.5021	0	No	No	Yes	No	5	7
34	8x48	8x52	dopamine_off	11.4552	1.63005	No	No	No	No	5	6
35	3x49	4x41	dopamine_off	10.4989	0	Yes	No	No	No	9	7
36	4x52	4x55	dopamine_off	11.2884	0	No	No	No	No	5	5
37	4x46	4x47	dopamine_off	12.0737	0	No	No	No	No	8	4
38	4x51	4x55	dopamine_off	10.8407	3.24466	No	No	No	No	5	5
39	3x37	3x41	dopamine_off	11.3901	0	Yes	No	No	No	8	7
40	4x47	4x51	dopamine_off	10.914	1.62343	No	No	No	No	4	5
41	6x44	6x48	Shared	100	61.1324	Yes	Yes	Yes	Yes	9	8
42	8x50	I1x50	Shared	15.4676	22.4325	Yes	Yes	Yes	Yes	9	9
43	2x46	3x42	Shared	90.9783	100	No	Yes	No	No	9	9
44	2x45	3x42	Shared	89.0331	89.2889	No	No	No	No	9	9
45	2x45	4x46	Shared	84.4551	83.8274	No	No	No	No	9	8
46	2x42	4x46	Shared	92.3537	82.451	Yes	Yes	No	No	7	8
47	2x42	3x49	Shared	69.6346	77.005	Yes	Yes	Yes	No	7	9
48	3x43	6x44	Shared	36.2375	67.4784	No	Yes	Yes	Yes	8	9
49	2x46	3x43	Shared	36.0462	71.0341	No	Yes	No	Yes	9	8
50	5x43	Lig	Shared	33.7674	32.1974	No	No	Yes	Yes	8	0
51	5x39	5x43	Shared	32.982	30.8254	Yes	Yes	No	No	7	8
52	3x47	5x58	Shared	10.0553	24.3714	No	No	Yes	Yes	9	9
53	5x62	5x66	Shared	20.6316	30.4107	No	Yes	No	No	6	6
54	5x47	6x52	Shared	26.2635	37.0081	Yes	Yes	Yes	Yes	9	7
55	1x39	7x39	Shared	11.2436	16.0138	No	No	Yes	No	7	8
56	3x49	I2x53	Shared	13.1277	28.4763	Yes	No	No	Yes	9	8
57	6x48	6x52	Shared	20.8472	57.5481	Yes	Yes	Yes	Yes	8	7
58	7x39	7x42	dopamine_on	0	17.0791	Yes	No	Yes	Yes	8	8
59	2x57	7x42	dopamine_on	6.71034	17.635	No	No	Yes	Yes	8	8
60	1x46	2x57	dopamine_on	0	13.1264	Yes	Yes	No	No	8	8
61	7x42	Lig	dopamine_on	7.54456	66.9975	Yes	Yes	Yes	Yes	8	0
62	3x36	Lig	dopamine_on	0.325547	44.6466	No	No	Yes	Yes	7	0
63	3x36	6x48	dopamine_on	1.07431	45.0084	No	No	Yes	Yes	7	8
64	6x48	7x45	dopamine_on	1.39985	42.0328	Yes	Yes	No	No	8	9
65	7x45	7x49	dopamine_on	0	41.2851	No	No	No	Yes	9	9
66	2x50	7x49	dopamine_on	0	13.0603	No	Yes	No	Yes	9	9
67	6x52	Lig	dopamine_on	7.49166	73.4758	Yes	Yes	Yes	Yes	7	0
68	2x39	3x49	dopamine_on	1.526	47.4501	No	No	Yes	No	8	9
69	2x39	2x40	dopamine_on	0	47.309	No	No	No	No	8	9
70	2x40	8x50	dopamine_on	1.88817	43.182	No	No	Yes	Yes	9	9
71	8x50	8x54	dopamine_on	3.29617	14.1256	Yes	Yes	No	Yes	9	9
72	5x47	6x44	dopamine_on	0	36.3817	Yes	Yes	Yes	Yes	9	9
73	2x46	7x49	dopamine_on	0	32.0297	No	Yes	No	Yes	9	9
74	2x38	I2x53	dopamine_on	0	21.2524	No	Yes	No	Yes	6	8
75	2x38	4x42	dopamine_on	0.0529014	12.9323	No	Yes	No	No	6	7
76	2x41	4x42	dopamine_on	4.96053	11.331	No	No	No	No	5	7
77	1x60	I1x50	dopamine_on	6.19354	17.7078	No	Yes	Yes	Yes	8	9
78	2x50	7x46	dopamine_on	6.61268	11.578	No	Yes	No	No	9	9
79	2x53	7x46	dopamine_on	0	10.4398	No	No	No	No	8	9
80	2x60	3x28	dopamine_on	0	22.084	Yes	Yes	No	No	8	7
81	2x60	2x64	dopamine_on	2.3887	10.7178	Yes	Yes	No	No	8	6
82	3x28	E1x50	dopamine_on	0	17.5909	No	No	Yes	Yes	7	9
83	5x39	E2	dopamine_on	0	11.053	Yes	Yes	Yes	Yes	7	4
84	3x42	4x49	dopamine_on	1.63181	11.331	No	No	No	No	9	7
85	3x43	7x53	dopamine_on	0	27.991	No	Yes	Yes	Yes	8	9
86	5x54	6x44	dopamine_on	0	42.2115	No	No	Yes	Yes	8	9
87	3x47	5x54	dopamine_on	5.06226	41.3292	No	No	No	No	9	8
88	3x47	5x57	dopamine_on	3.38162	20.2422	No	No	No	No	9	7
89	3x51	5x57	dopamine_on	0	19.1658	No	Yes	No	No	9	7
90	3x51	3x55	dopamine_on	1.69285	12.6147	No	Yes	No	No	9	7
91	3x55	3x56	dopamine_on	0	11.5074	No	No	No	No	7	6
92	6x55	Lig	dopamine_on	3.19036	10.8788	Yes	No	Yes	Yes	8	0
93	5x40	6x55	dopamine_on	1.90038	14.9131	No	No	Yes	No	7	8
94	5x40	6x59	dopamine_on	0	12.4382	No	No	No	No	7	6
95	5x58	6x37	dopamine_on	0	36.6596	Yes	Yes	No	No	9	8
96	6x40	7x53	dopamine_on	0	12.4074	No	No	Yes	Yes	8	9
97	5x62	6x37	dopamine_on	0	35.3406	No	Yes	No	No	6	8
98	5x66	6x30	dopamine_on	0	27.7859	No	No	No	Yes	6	8
99	5x69	6x30	dopamine_on	0	17.8401	No	No	No	Yes	5	8
100	6x51	7x34	dopamine_on	0	15.941	Yes	Yes	No	No	8	4
101	6x58	7x34	dopamine_on	0	15.0388	No	No	No	No	5	4
102	6x58	E3	dopamine_on	1.71319	13.8874	No	No	Yes	Yes	5	4
103	6x54	E3	dopamine_on	0	10.678	No	No	Yes	Yes	6	4
104	1x60	8x56	dopamine_on	0	10.131	No	Yes	No	No	8	6
105	1x39	2x61	dopamine_on	5.69301	11.5008	No	No	No	No	7	6
106	5x69	5x73	dopamine_on	0	11.514	No	No	No	No	5	0
107	5x73	5x77	dopamine_on	0	10.1244	No	No	No	No	0	0
108	2x60	7x42	dopamine_on	0.516806	33.062	Yes	Yes	Yes	Yes	8	8
109	6x51	6x52	dopamine_on	0.415073	19.6158	Yes	Yes	Yes	Yes	8	7

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
2x56	3x32	Shared	5.67778	6.89472	0	1	2	1
2x57	7x42	Shared	6.86111	7.61083	0	0	2	1
2x59	3x28	Shared	12.4533	7.41083	0	0	2	1
2x60	7x42	Shared	7.00889	5.55417	1	1	1	1
2x60	Lig	dopamine_off	4.57	0	1	1	1	0
3x28	Lig	dopamine_off	4.07222	0	0	0	1	0
3x29	E2x52	dopamine_off	3.76	0	0	0	2	1
3x32	7x42	Shared	8.17778	9.0893	1	1	1	1
3x32	Lig	Shared	19.5267	13.755	1	1	1	0
3x33	4x57	Shared	4.00222	4.91181	0	0	1	2
3x33	Lig	Shared	7.94778	11.7262	0	0	1	0
3x36	6x48	Shared	6.53	4.18306	1	0	1	1
3x36	Lig	Shared	6.56222	6.32681	1	0	1	0
3x37	4x56	dopamine_off	4.37889	0	0	0	2	2
3x37	5x461	Shared	8.52667	8.61472	0	0	2	1
3x40	6x44	Shared	7.58	3.80403	0	1	2	2
E2x52	Lig	Shared	8.93222	5.10972	0	0	1	0
5x39	5x43	Shared	5.07222	10.4729	0	2	2	1
5x40	6x55	Shared	5.22556	6.04028	0	0	2	1
5x43	Lig	Shared	5.18556	6.99194	0	0	1	0
5x47	6x52	Shared	24.1733	22.8326	0	1	2	1
6x44	6x48	Shared	14.2556	6.20819	1	1	2	1
6x44	7x45	dopamine_off	8.19	0	1	1	2	2
6x48	6x51	dopamine_off	7.23556	0	1	1	1	1
6x48	6x52	Shared	4.78667	6.38972	1	1	1	1
6x48	7x41	Shared	11.26	5.82264	1	1	1	2
6x48	7x45	Shared	4.26889	10.0288	1	1	1	2
6x48	Lig	dopamine_off	7.23333	0	1	1	1	0
6x51	6x52	Shared	6.91111	8.02403	1	1	1	1
6x51	6x55	Shared	15.0833	7.47972	1	1	1	1
6x51	7x38	Shared	4.03333	4.2875	1	1	1	1
6x51	Lig	Shared	12.4411	14.4264	1	1	1	0
6x52	Lig	Shared	7.98889	7.52472	1	1	1	0
6x55	7x34	dopamine_off	8.06111	0	1	1	1	2
6x55	Lig	Shared	5.28667	5.54208	1	1	1	0
7x38	Lig	Shared	4.06556	6.53431	1	1	1	0
7x42	Lig	Shared	6.41	8.08292	1	1	1	0
2x60	7x39	Shared	5.97778	3.89208	1	1	1	2
2x64	7x39	dopamine_off	5.93444	0	1	0	2	2
2x60	2x64	Shared	3.49667	3.41917	1	1	1	2
5x44	6x52	Shared	3.22667	5.75972	0	0	2	1
2x56	7x42	dopamine_on	0	4.09403	0	1	2	1
2x60	3x28	dopamine_on	0	4.30931	1	1	1	1
3x28	E1x50	dopamine_on	0	5.95264	0	0	1	2
3x40	6x48	dopamine_on	0	11.9403	0	1	2	1
5x461	Lig	dopamine_on	0	4.35444	0	0	1	0
5x47	6x44	dopamine_on	0	4.46722	0	1	2	2
6x51	7x34	dopamine_on	0	3.83597	1	1	1	2
7x38	7x42	dopamine_on	0	5.48014	1	1	1	1
7x39	7x42	dopamine_on	0	6.37403	1	1	2	1
4x56	5x461	dopamine_on	0	3.18458	6	0	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	dopamine_off	d3_off d2_off d4_off
	dopamine_on	d3_on d2_on d5_on d1_on

Network Difference
Value	dopamine_off	dopamine_on
I_min	3.42	3.64556
Number of Linked Nodes	264	286
Number of Specific Nodes	3 (1.14%)	25 (8.74%)
Number of Shared Nodes	261 (98.86%)	261 (91.26%)
Number of Links	284	308
Number of Specific Links	117 (41.20%)	141 (45.78%)
Number of Shared Links	167 (58.80%)	167 (54.22%)
Number of Hubs	27	34
Number of Specific Hubs	8 (29.63%)	15 (44.12%)
Number of Shared Hubs	19 (70.37%)	19 (55.88%)
Average % Shared Neighbours (Jaccard)	41.93
Average % Shared Neighbours (Otsuka)	50.55
Average % Shared Neighbours (Overlap Coefficient)	59.19
Average % Shared Cliques (k3-6)	54.46
Graphlets Similarity	0.571848

Paths Difference
Value	dopamine_off	dopamine_on
Number Of Nodes in MetaPath	58	67
Specific Nodes in MetaPath	29 (50.00%)	38 (56.72%)
Shared Nodes in MetaPath	261 (98.86%)	261 (98.86%)
Number Of Links MetaPath	57	69
Specific Links in MetaPath	40 (70.18%)	52 (75.36%)
Shared Links in MetaPath	167 (58.80%)	167 (58.80%)
Number of Shortest Paths	45346	89894
Length Of Smallest Path	3	3
Average Path Length	14.1694	15.2248
Length of Longest Path	29	30
Minimum Path Strength	0.53	0.223056
Average Path Strength	5.6996	5.82721
Maximum Path Strength	16.3878	16.8033
Minimum Path Correlation	0.7	0.70125
Average Path Correlation	0.909679	0.913071
Maximum Path Correlation	0.99	0.990278
Minimum % Of Corr. Nodes	4	3.84615
Average % Of Corr. Nodes	40.4802	37.4311
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	36.014	45.7222
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download dopamine_off_on.zip<

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