psnGPCR

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Orange: nodes, hubs and links specific of endothelin_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of endothelin_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	endothelin_off Int. Strength	endothelin_on Int. Strength	endothelin_off Hub1?	endothelin_on Hub1?	endothelin_off Hub2?	endothelin_on Hub2?	ConSurf1	ConSurf2
1	2x53	Lig	endothelin_off	100	0	Yes	Yes	Yes	Yes	8	0
2	2x63	Lig	endothelin_off	100	0	No	No	Yes	Yes	5	0
3	3x29	Lig	endothelin_off	100	0	Yes	No	Yes	Yes	5	0
4	3x36	Lig	endothelin_off	100	0	No	Yes	Yes	Yes	7	0
5	4x65	Lig	endothelin_off	100	0	Yes	No	Yes	Yes	5	0
6	6x52	Lig	endothelin_off	100	0	Yes	Yes	Yes	Yes	8	0
7	1x24	7x27	endothelin_off	100	0	No	No	No	No	4	3
8	1x27	7x32	endothelin_off	100	0	No	No	No	No	5	1
9	1x28	7x35	endothelin_off	100	0	No	No	Yes	Yes	3	3
10	1x31	1x34	endothelin_off	100	0	Yes	Yes	No	No	4	5
11	1x31	1x35	endothelin_off	100	0	Yes	Yes	Yes	No	4	5
12	1x32	E1	endothelin_off	100	0	Yes	Yes	No	No	6	4
13	1x35	2x64	endothelin_off	100	0	Yes	No	No	No	5	4
14	1x42	7x47	endothelin_off	100	0	No	No	No	No	8	8
15	1x52	8x54	endothelin_off	100	0	No	No	Yes	No	6	7
16	1x53	2x43	endothelin_off	100	0	Yes	No	No	No	9	8
17	1x53	7x50	endothelin_off	100	0	Yes	No	No	No	9	9
18	1x53	7x53	endothelin_off	100	0	Yes	No	No	No	9	9
19	1x54	2x48	endothelin_off	100	0	No	No	No	No	7	6
20	1x58	1x59	endothelin_off	100	0	No	No	No	No	2	4
21	8x49	I1x50	endothelin_off	100	0	No	No	Yes	No	6	7
22	I1x52	I2x54	endothelin_off	100	0	No	No	Yes	No	8	4
23	2x39	3x50	endothelin_off	100	0	No	No	Yes	No	8	9
24	2x40	3x50	endothelin_off	100	0	Yes	No	Yes	No	8	9
25	2x40	8x50	endothelin_off	100	0	Yes	No	Yes	Yes	8	9
26	2x45	4x50	endothelin_off	100	0	No	No	No	No	9	9
27	2x46	3x39	endothelin_off	100	0	Yes	Yes	No	No	9	9
28	2x53	2x57	endothelin_off	100	0	Yes	Yes	Yes	No	8	7
29	2x53	3x32	endothelin_off	100	0	Yes	Yes	No	No	8	6
30	2x53	7x46	endothelin_off	100	0	Yes	Yes	No	No	8	9
31	2x57	2x58	endothelin_off	100	0	Yes	No	No	No	7	9
32	2x59	E1x52	endothelin_off	100	0	No	No	Yes	No	6	7
33	2x59	3x28	endothelin_off	100	0	No	No	No	No	6	5
34	2x62	E1x52	endothelin_off	100	0	No	No	Yes	No	4	7
35	E1x50	E1x52	endothelin_off	100	0	Yes	Yes	Yes	No	9	7
36	E1x50	E2	endothelin_off	100	0	Yes	Yes	Yes	Yes	9	3
37	E1x51	E1x52	endothelin_off	100	0	No	No	Yes	No	2	7
38	3x26	E2	endothelin_off	100	0	No	No	Yes	Yes	7	3
39	3x33	5x43	endothelin_off	100	0	Yes	No	No	Yes	4	6
40	3x40	6x44	endothelin_off	100	0	No	No	Yes	Yes	8	9
41	3x41	4x53	endothelin_off	100	0	No	No	No	No	6	8
42	3x46	6x37	endothelin_off	100	0	No	No	No	No	9	8
43	3x48	3x52	endothelin_off	100	0	No	No	No	No	6	5
44	3x49	4x45	endothelin_off	100	0	No	No	No	No	8	6
45	3x50	6x33	endothelin_off	100	0	Yes	No	No	No	9	8
46	3x50	6x37	endothelin_off	100	0	Yes	No	No	No	9	8
47	3x54	5x65	endothelin_off	100	0	No	No	Yes	Yes	9	8
48	5x68	I2x50	endothelin_off	100	0	No	No	No	No	5	8
49	6x26	I2x50	endothelin_off	100	0	Yes	No	No	No	4	8
50	4x64	E2	endothelin_off	100	0	No	No	Yes	Yes	5	3
51	E2	E2x50	endothelin_off	100	0	Yes	Yes	No	No	3	9
52	5x29	E2	endothelin_off	100	0	No	No	Yes	Yes	3	3
53	5x41	6x59	endothelin_off	100	0	No	No	No	No	5	5
54	5x42	5x461	endothelin_off	100	0	Yes	Yes	No	No	4	6
55	5x44	6x56	endothelin_off	100	0	Yes	No	No	No	6	6
56	5x47	5x51	endothelin_off	100	0	Yes	No	No	No	8	7
57	5x58	5x62	endothelin_off	100	0	Yes	Yes	No	No	9	5
58	5x64	5x68	endothelin_off	100	0	Yes	No	No	No	5	5
59	6x24	6x26	endothelin_off	100	0	No	No	Yes	No	2	4
60	6x24	6x27	endothelin_off	100	0	No	No	No	No	2	4
61	6x26	6x30	endothelin_off	100	0	Yes	No	No	No	4	7
62	6x32	8x47	endothelin_off	100	0	No	No	No	No	7	8
63	6x35	7x56	endothelin_off	100	0	No	No	No	No	5	7
64	6x36	8x47	endothelin_off	100	0	No	No	No	No	8	8
65	6x39	7x56	endothelin_off	100	0	No	No	No	No	5	7
66	6x40	7x53	endothelin_off	100	0	No	No	No	No	8	9
67	6x51	6x55	endothelin_off	100	0	No	No	No	Yes	6	6
68	6x51	7x37	endothelin_off	100	0	No	No	No	No	6	7
69	6x53	6x57	endothelin_off	100	0	No	No	No	No	6	5
70	7x25	E3	endothelin_off	100	0	No	No	Yes	Yes	4	1
71	7x31	7x35	endothelin_off	100	0	No	No	Yes	Yes	3	3
72	8x51	8x55	endothelin_off	100	0	No	No	No	No	8	4
73	3x52	4x41	endothelin_off	100	0	No	No	Yes	No	5	5
74	6x32	8x48	endothelin_off	100	0	No	No	No	No	7	5
75	5x64	I2x54	endothelin_off	100	0	Yes	No	Yes	No	5	4
76	6x28	8x48	endothelin_off	66.6667	0	No	No	No	No	4	5
77	6x29	6x33	endothelin_off	66.6667	0	No	No	No	No	5	8
78	6x31	6x35	endothelin_off	33.3333	0	No	No	No	No	5	5
79	3x24	3x27	endothelin_off	33.3333	0	No	No	No	No	6	5
80	1x22	1x23	endothelin_off	33.3333	0	No	No	No	No	4	4
81	6x49	6x50	endothelin_off	33.3333	0	No	No	No	No	5	9
82	2x56	3x31	endothelin_off	33.3333	0	No	Yes	No	No	6	5
83	7x23	7x24	endothelin_off	33.3333	0	No	Yes	No	No	5	8
84	6x58	6x62	endothelin_off	33.3333	0	No	No	Yes	Yes	4	2
85	7x45	7x49	endothelin_off	33.3333	0	Yes	No	Yes	No	9	9
86	6x62	7x26	endothelin_off	33.3333	0	Yes	Yes	No	No	2	2
87	1x27	7x28	endothelin_off	33.3333	0	No	No	No	No	5	3
88	3x47	5x57	endothelin_off	33.3333	0	No	No	Yes	Yes	9	7
89	3x45	4x45	endothelin_off	33.3333	0	No	No	No	No	7	6
90	2x49	3x38	endothelin_off	66.6667	0	No	No	No	No	8	7
91	7x36	7x40	endothelin_off	0	0	No	No	No	No	5	7
92	7x29	7x30	endothelin_off	33.3333	0	No	No	No	No	3	3
93	1x41	1x45	endothelin_off	33.3333	0	No	No	No	No	4	5
94	2x60	2x64	endothelin_off	33.3333	0	No	No	No	No	7	4
95	2x39	3x49	endothelin_off	33.3333	0	No	No	No	No	8	8
96	3x55	I2x50	endothelin_off	33.3333	0	No	No	No	No	7	8
97	1x39	2x57	endothelin_off	33.3333	0	No	No	Yes	No	7	7
98	2x41	4x42	endothelin_off	33.3333	0	No	No	No	No	6	7
99	1x51	2x51	endothelin_off	33.3333	0	No	No	No	No	4	7
100	5x31	5x32	endothelin_off	33.3333	0	No	No	No	Yes	3	4
101	1x42	7x43	endothelin_off	0	0	No	No	No	No	8	6
102	I1x48	I1x51	endothelin_off	33.3333	0	No	No	No	No	6	7
103	3x56	5x64	endothelin_off	33.3333	0	No	No	Yes	No	7	5
104	1x26	1x30	endothelin_off	33.3333	0	No	No	No	No	5	5
105	6x27	I3	endothelin_off	33.3333	0	No	No	No	No	4	4
106	5x65	6x34	endothelin_off	0	0	Yes	Yes	No	No	8	7
107	7x42	Lig	endothelin_off	33.3333	0	No	No	Yes	Yes	7	0
108	I1x51	I1x52	endothelin_off	33.3333	0	No	No	No	No	7	8
109	6x43	7x49	endothelin_off	0	0	No	No	Yes	No	6	9
110	1x46	7x47	endothelin_off	0	0	No	No	No	No	8	8
111	2x41	4x46	endothelin_off	0	0	No	No	No	No	6	7
112	1x54	1x58	endothelin_off	33.3333	0	No	No	No	No	7	2
113	7x51	7x55	endothelin_off	0	0	No	No	No	No	7	6
114	3x53	I2x52	endothelin_off	33.3333	0	No	No	No	Yes	8	5
115	6x39	7x52	endothelin_off	0	0	No	No	No	No	5	7
116	3x34	4x57	endothelin_off	0	0	No	No	No	No	6	7
117	8x50	8x54	endothelin_off	0	0	Yes	Yes	Yes	No	9	7
118	5x58	6x34	endothelin_off	0	0	Yes	Yes	No	No	9	7
119	1x36	1x40	endothelin_off	0	0	Yes	No	No	No	6	4
120	6x38	6x42	endothelin_off	0	0	No	No	No	No	5	5
121	1x56	8x57	endothelin_off	0	0	No	Yes	No	No	7	6
122	5x41	6x60	endothelin_off	0	0	No	No	No	No	5	4
123	5x36	E2x52	endothelin_off	0	0	No	No	No	No	4	5
124	1x44	1x48	endothelin_off	0	0	No	No	No	No	5	5
125	1x47	2x55	endothelin_off	0	0	No	No	No	No	7	5
126	8x52	8x56	endothelin_off	33.3333	0	No	No	No	No	4	5
127	1x36	2x64	endothelin_off	33.3333	0	Yes	No	No	No	6	4
128	1x32	2x65	endothelin_off	33.3333	0	Yes	Yes	No	No	6	4
129	3x21	E1x50	endothelin_off	0	0	No	No	Yes	Yes	8	9
130	1x22	1x25	endothelin_off	0	0	No	No	No	No	4	4
131	1x25	1x26	endothelin_off	33.3333	0	No	No	No	No	4	5
132	I2x53	I2x57	endothelin_off	33.3333	0	No	No	No	No	6	6
133	I2x54	I2x55	endothelin_off	0	0	Yes	No	No	No	4	3
134	3x53	I2x51	endothelin_off	0	0	No	No	No	No	8	5
135	3x21	3x23	endothelin_off	0	0	No	No	No	No	8	1
136	8x55	8x59	endothelin_off	0	0	No	No	No	No	4	5
137	4x47	4x51	endothelin_off	0	0	No	No	No	No	3	4
138	4x44	4x48	endothelin_off	0	0	No	No	No	No	3	3
139	5x33	5x37	endothelin_off	0	0	No	No	No	No	1	4
140	5x58	5x59	endothelin_off	0	0	Yes	Yes	No	No	9	4
141	4x41	I2x53	endothelin_off	0	0	Yes	No	No	No	5	6
142	I2x55	I2x56	endothelin_off	0	0	No	No	No	No	3	3
143	5x59	5x63	endothelin_off	0	0	No	No	No	No	4	4
144	5x62	5x63	endothelin_off	0	0	No	No	No	No	5	4
145	1x36	1x37	endothelin_off	0	0	Yes	No	No	No	6	6
146	5x44	5x45	endothelin_off	0	0	Yes	No	No	No	6	4
147	5x64	5x67	endothelin_off	0	0	Yes	No	No	No	5	4
148	2x60	Lig	Shared	100	100	No	No	Yes	Yes	7	0
149	3x32	Lig	Shared	100	100	No	No	Yes	Yes	6	0
150	3x33	Lig	Shared	100	100	Yes	No	Yes	Yes	4	0
151	5x43	Lig	Shared	100	100	No	Yes	Yes	Yes	6	0
152	6x48	Lig	Shared	100	100	Yes	Yes	Yes	Yes	8	0
153	6x51	Lig	Shared	100	100	No	No	Yes	Yes	6	0
154	6x55	Lig	Shared	100	100	No	Yes	Yes	Yes	6	0
155	7x38	Lig	Shared	100	100	No	No	Yes	Yes	6	0
156	E2	NT	Shared	100	100	Yes	Yes	No	Yes	3	6
157	7x24	NT	Shared	100	100	No	No	No	Yes	8	6
158	1x23	1x24	Shared	100	50	No	No	No	No	4	4
159	1x27	7x31	Shared	100	100	No	No	No	No	5	3
160	1x29	1x32	Shared	100	100	No	No	Yes	Yes	3	6
161	1x31	7x32	Shared	100	100	Yes	Yes	No	No	4	1
162	1x31	7x35	Shared	100	50	Yes	Yes	Yes	Yes	4	3
163	1x35	7x35	Shared	100	100	Yes	No	Yes	Yes	5	3
164	1x35	7x39	Shared	100	100	Yes	No	No	No	5	5
165	1x38	7x39	Shared	100	0	No	No	No	No	5	5
166	1x39	2x61	Shared	100	75	No	No	No	No	7	7
167	1x42	7x42	Shared	100	100	No	No	No	No	8	7
168	1x43	2x57	Shared	100	100	No	No	Yes	No	7	7
169	1x43	2x58	Shared	100	100	No	No	No	No	7	9
170	1x49	7x50	Shared	100	25	No	No	No	No	8	9
171	1x50	2x47	Shared	100	75	Yes	Yes	No	No	9	9
172	1x50	2x50	Shared	100	100	Yes	Yes	No	Yes	9	9
173	1x50	7x50	Shared	100	100	Yes	Yes	No	No	9	9
174	1x52	8x58	Shared	100	0	No	No	No	No	6	6
175	1x53	2x47	Shared	100	50	Yes	No	No	No	9	9
176	1x53	8x50	Shared	100	100	Yes	No	Yes	Yes	9	9
177	1x55	1x59	Shared	100	100	No	No	No	No	3	4
178	1x56	8x53	Shared	100	100	No	Yes	No	No	7	4
179	1x56	8x54	Shared	100	50	No	Yes	Yes	No	7	7
180	1x57	2x44	Shared	100	100	No	No	No	No	7	7
181	1x60	I1x50	Shared	100	100	No	No	Yes	No	6	7
182	2x40	I1x50	Shared	100	100	Yes	No	Yes	No	8	7
183	8x50	I1x50	Shared	100	50	Yes	Yes	Yes	No	9	7
184	2x38	2x39	Shared	100	100	No	No	No	No	7	8
185	2x45	4x46	Shared	100	100	No	No	No	No	9	7
186	2x46	3x42	Shared	100	100	Yes	Yes	No	No	9	8
187	2x46	7x49	Shared	100	100	Yes	Yes	Yes	No	9	9
188	2x48	4x50	Shared	100	0	No	No	No	No	6	9
189	2x50	3x39	Shared	100	100	No	Yes	No	No	9	9
190	2x53	2x56	Shared	100	100	Yes	Yes	No	Yes	8	6
191	2x53	3x35	Shared	100	50	Yes	Yes	No	No	8	8
192	2x54	7x46	Shared	100	25	No	No	No	No	6	9
193	2x551	3x31	Shared	100	100	No	No	No	No	5	5
194	2x63	E1x50	Shared	100	100	No	No	Yes	Yes	5	9
195	E1x49	E2	Shared	100	100	No	No	Yes	Yes	5	3
196	E1x50	E1x51	Shared	100	100	Yes	Yes	No	No	9	2
197	3x25	E1x50	Shared	100	100	No	No	Yes	Yes	9	9
198	E1x50	E2x50	Shared	100	100	Yes	Yes	No	No	9	9
199	3x24	E1x52	Shared	100	100	No	No	Yes	No	6	7
200	3x25	E2x50	Shared	100	100	No	No	No	No	9	9
201	3x28	3x29	Shared	100	50	No	No	Yes	No	5	5
202	3x29	4x61	Shared	100	100	Yes	No	Yes	Yes	5	5
203	3x29	4x65	Shared	100	100	Yes	No	Yes	No	5	5
204	3x30	4x54	Shared	100	100	Yes	Yes	No	No	6	3
205	3x30	4x57	Shared	100	100	Yes	Yes	No	No	6	7
206	3x32	3x33	Shared	100	100	No	No	Yes	No	6	4
207	3x33	4x61	Shared	100	100	Yes	No	Yes	Yes	4	5
208	3x36	5x461	Shared	100	100	No	Yes	No	No	7	6
209	3x36	6x48	Shared	100	100	No	Yes	Yes	Yes	7	8
210	3x37	4x53	Shared	100	100	No	No	No	No	6	8
211	3x38	4x50	Shared	100	100	No	No	No	No	7	9
212	3x38	4x53	Shared	100	100	No	No	No	No	7	8
213	3x40	5x50	Shared	100	100	No	No	No	No	8	9
214	3x41	4x49	Shared	100	100	No	No	No	No	6	7
215	3x42	4x49	Shared	100	50	No	No	No	No	8	7
216	3x44	5x53	Shared	100	100	No	No	No	No	8	7
217	3x47	5x54	Shared	100	100	No	No	No	No	9	8
218	3x48	5x57	Shared	100	100	No	No	Yes	Yes	6	7
219	3x49	3x52	Shared	100	100	No	No	No	No	8	5
220	3x51	5x57	Shared	100	100	No	Yes	Yes	Yes	8	7
221	3x51	5x60	Shared	100	100	No	Yes	No	No	8	3
222	3x54	5x61	Shared	100	100	No	No	No	Yes	9	8
223	4x38	4x39	Shared	100	75	No	No	No	No	6	1
224	4x41	4x44	Shared	100	25	Yes	No	No	No	5	3
225	4x56	5x42	Shared	100	100	No	No	Yes	Yes	5	4
226	4x56	5x46	Shared	100	100	No	No	Yes	Yes	5	5
227	4x59	4x60	Shared	100	100	No	No	No	No	4	8
228	4x60	5x35	Shared	100	100	No	No	Yes	Yes	8	3
229	4x61	4x65	Shared	100	100	Yes	Yes	Yes	No	5	5
230	4x61	5x35	Shared	100	100	Yes	Yes	Yes	Yes	5	3
231	4x61	5x39	Shared	100	100	Yes	Yes	No	Yes	5	7
232	4x63	5x32	Shared	100	0	No	No	No	Yes	5	4
233	4x65	E2x52	Shared	100	100	Yes	No	No	No	5	5
234	E2	E2	Shared	100	100	Yes	Yes	Yes	Yes	3	3
235	E2	E2x51	Shared	100	100	Yes	Yes	No	No	3	4
236	5x32	E2	Shared	100	100	No	Yes	Yes	Yes	4	3
237	5x33	E2	Shared	100	0	No	No	Yes	Yes	1	3
238	5x35	5x39	Shared	100	100	Yes	Yes	No	Yes	3	7
239	5x35	5x42	Shared	100	100	Yes	Yes	Yes	Yes	3	4
240	5x39	5x43	Shared	100	100	No	Yes	No	Yes	7	6
241	5x40	6x59	Shared	100	100	No	Yes	No	No	5	5
242	5x41	6x56	Shared	100	100	No	No	No	No	5	6
243	5x42	5x46	Shared	100	100	Yes	Yes	Yes	Yes	4	5
244	5x44	5x47	Shared	100	100	Yes	No	Yes	No	6	8
245	5x44	5x48	Shared	100	100	Yes	No	No	No	6	5
246	5x44	6x52	Shared	100	100	Yes	No	Yes	Yes	6	8
247	5x46	5x461	Shared	100	100	Yes	Yes	No	No	5	6
248	5x46	5x49	Shared	100	50	Yes	Yes	No	No	5	6
249	5x47	6x49	Shared	100	100	Yes	No	No	No	8	5
250	5x47	6x52	Shared	100	100	Yes	No	Yes	Yes	8	8
251	5x54	6x41	Shared	100	100	No	No	No	No	8	8
252	5x56	5x57	Shared	100	100	No	No	Yes	Yes	4	7
253	5x56	5x60	Shared	100	100	No	No	No	No	4	3
254	5x58	6x38	Shared	100	50	Yes	Yes	No	No	9	5
255	5x61	5x65	Shared	100	100	No	Yes	Yes	Yes	8	8
256	5x65	6x30	Shared	100	100	Yes	Yes	No	No	8	7
257	5x68	6x30	Shared	100	25	No	No	No	No	5	7
258	6x40	7x49	Shared	100	0	No	No	Yes	No	8	9
259	6x42	6x46	Shared	100	100	No	No	No	No	5	5
260	6x44	6x48	Shared	100	100	Yes	Yes	Yes	Yes	9	8
261	6x44	7x45	Shared	100	100	Yes	Yes	Yes	No	9	9
262	6x47	7x45	Shared	100	100	No	No	Yes	No	8	9
263	6x48	6x52	Shared	100	100	Yes	Yes	Yes	Yes	8	8
264	6x48	7x41	Shared	100	100	Yes	Yes	No	No	8	8
265	6x48	7x45	Shared	100	100	Yes	Yes	Yes	No	8	9
266	6x50	7x40	Shared	100	100	No	No	No	No	9	7
267	6x54	7x34	Shared	100	100	No	No	No	No	5	4
268	6x55	7x34	Shared	100	100	No	Yes	No	No	6	4
269	6x60	6x61	Shared	100	100	No	No	No	No	4	3
270	6x62	E3	Shared	100	100	Yes	Yes	Yes	Yes	2	1
271	6x62	7x23	Shared	100	100	Yes	Yes	No	Yes	2	5
272	6x62	7x27	Shared	100	100	Yes	Yes	No	No	2	3
273	E3	E3	Shared	100	100	Yes	Yes	Yes	Yes	1	1
274	7x23	E3	Shared	100	100	No	Yes	Yes	Yes	5	1
275	7x26	7x30	Shared	100	100	No	No	No	No	2	3
276	7x53	8x50	Shared	100	100	No	No	Yes	Yes	9	9
277	7x54	8x51	Shared	100	50	Yes	Yes	No	No	7	8
278	7x54	8x54	Shared	100	50	Yes	Yes	Yes	No	7	7
279	7x54	8x55	Shared	100	25	Yes	Yes	No	No	7	4
280	8x47	8x50	Shared	100	100	No	No	Yes	Yes	8	9
281	1x43	1x47	Shared	100	100	No	No	No	No	7	7
282	2x40	I1x52	Shared	100	100	Yes	No	No	No	8	8
283	2x46	2x50	Shared	100	100	Yes	Yes	No	Yes	9	9
284	2x62	2x66	Shared	100	25	No	No	No	No	4	5
285	2x62	E1x51	Shared	100	100	No	No	No	No	4	2
286	4x41	4x45	Shared	100	100	Yes	No	No	No	5	6
287	8x51	8x52	Shared	100	0	No	No	No	No	8	4
288	4x39	4x42	Shared	33.3333	100	No	No	No	No	1	7
289	4x52	4x56	Shared	33.3333	100	No	No	No	No	4	5
290	1x36	2x65	Shared	66.6667	50	Yes	No	No	No	6	4
291	1x53	1x57	Shared	33.3333	50	Yes	No	No	No	9	7
292	I2x52	I2x54	Shared	33.3333	0	No	Yes	Yes	No	5	4
293	3x43	6x44	Shared	66.6667	75	No	No	Yes	Yes	8	9
294	5x34	5x38	Shared	66.6667	50	No	No	No	No	1	4
295	3x30	4x62	Shared	66.6667	100	Yes	Yes	No	No	6	4
296	2x42	3x46	Shared	33.3333	100	No	No	No	No	7	9
297	1x50	2x51	Shared	33.3333	100	Yes	Yes	No	No	9	7
298	1x45	7x47	Shared	33.3333	100	No	No	No	No	5	8
299	5x51	6x45	Shared	33.3333	100	No	No	No	No	7	6
300	1x60	I1x49	Shared	33.3333	50	No	No	No	No	6	5
301	3x30	3x31	Shared	66.6667	100	Yes	Yes	No	No	6	5
302	6x54	7x33	Shared	33.3333	100	No	No	No	No	5	5
303	3x22	E2	Shared	33.3333	0	No	No	Yes	Yes	3	3
304	5x53	5x57	Shared	0	0	No	No	Yes	Yes	7	7
305	2x52	3x35	Shared	33.3333	100	No	No	No	No	7	8
306	1x32	1x33	Shared	33.3333	100	Yes	Yes	No	No	6	3
307	6x57	7x30	Shared	33.3333	100	No	No	No	No	5	3
308	6x36	7x56	Shared	33.3333	100	No	No	No	No	8	7
309	1x48	1x49	Shared	0	25	No	No	No	No	5	8
310	6x43	7x48	Shared	0	100	No	No	No	No	6	6
311	4x51	4x55	Shared	0	0	No	No	No	No	4	4
312	7x54	7x55	Shared	0	50	Yes	Yes	No	No	7	6
313	2x55	2x551	Shared	0	0	No	No	No	No	5	5
314	4x48	4x52	Shared	0	0	No	No	No	No	3	4
315	I2x56	I2x57	Shared	0	50	No	No	No	No	3	6
316	4x38	4x43	Shared	0	0	No	No	No	No	6	3
317	6x25	6x26	Shared	0	100	No	No	Yes	No	3	4
318	Lig	Lig	endothelin_on	0	100	Yes	Yes	Yes	Yes	0	0
319	6x58	Lig	endothelin_on	0	100	No	No	Yes	Yes	4	0
320	5x36	Lig	endothelin_on	0	100	No	No	Yes	Yes	4	0
321	E2	Lig	endothelin_on	0	100	Yes	Yes	Yes	Yes	3	0
322	E3	Lig	endothelin_on	0	100	Yes	Yes	Yes	Yes	1	0
323	6x62	Lig	endothelin_on	0	100	Yes	Yes	Yes	Yes	2	0
324	7x23	Lig	endothelin_on	0	100	No	Yes	Yes	Yes	5	0
325	Lig	NT	endothelin_on	0	100	Yes	Yes	No	Yes	0	6
326	7x27	Lig	endothelin_on	0	100	No	No	Yes	Yes	3	0
327	1x25	Lig	endothelin_on	0	100	No	No	Yes	Yes	4	0
328	7x31	Lig	endothelin_on	0	100	No	No	Yes	Yes	3	0
329	7x34	Lig	endothelin_on	0	100	No	No	Yes	Yes	4	0
330	E2x51	Lig	endothelin_on	0	100	No	No	Yes	Yes	4	0
331	E1	Lig	endothelin_on	0	100	No	No	Yes	Yes	4	0
332	7x35	Lig	endothelin_on	0	100	Yes	Yes	Yes	Yes	3	0
333	2x59	Lig	endothelin_on	0	100	No	No	Yes	Yes	6	0
334	E1x50	Lig	endothelin_on	0	100	Yes	Yes	Yes	Yes	9	0
335	NT	NT	endothelin_on	0	100	No	Yes	No	Yes	6	6
336	7x23	NT	endothelin_on	0	100	No	Yes	No	Yes	5	6
337	1x29	1x33	endothelin_on	0	100	No	No	No	No	3	3
338	1x35	1x39	endothelin_on	0	100	Yes	No	No	No	5	7
339	1x39	7x39	endothelin_on	0	100	No	No	No	No	7	5
340	2x39	I1x52	endothelin_on	0	100	No	No	No	No	8	8
341	2x38	4x42	endothelin_on	0	100	No	No	No	No	7	7
342	2x42	3x45	endothelin_on	0	100	No	No	No	No	7	7
343	2x43	3x46	endothelin_on	0	100	No	No	No	No	8	9
344	2x45	3x42	endothelin_on	0	100	No	No	No	No	9	8
345	2x46	3x43	endothelin_on	0	100	Yes	Yes	No	No	9	8
346	2x50	7x46	endothelin_on	0	100	No	Yes	No	No	9	9
347	2x53	3x36	endothelin_on	0	100	Yes	Yes	No	Yes	8	7
348	2x53	6x48	endothelin_on	0	100	Yes	Yes	Yes	Yes	8	8
349	2x54	2x57	endothelin_on	0	100	No	No	Yes	No	6	7
350	2x56	2x60	endothelin_on	0	100	No	Yes	No	No	6	7
351	2x56	3x32	endothelin_on	0	100	No	Yes	No	No	6	6
352	2x57	7x42	endothelin_on	0	100	Yes	No	No	No	7	7
353	2x60	7x38	endothelin_on	0	100	No	No	No	No	7	6
354	2x64	7x35	endothelin_on	0	100	No	No	Yes	Yes	4	3
355	E1x49	E1x51	endothelin_on	0	100	No	No	No	No	5	2
356	3x46	3x50	endothelin_on	0	100	No	No	Yes	No	9	9
357	3x47	5x58	endothelin_on	0	100	No	No	Yes	Yes	9	9
358	3x50	5x58	endothelin_on	0	100	Yes	No	Yes	Yes	9	9
359	3x51	3x55	endothelin_on	0	100	No	Yes	No	No	8	7
360	I2x50	I2x51	endothelin_on	0	100	No	No	No	No	8	5
361	4x46	4x50	endothelin_on	0	100	No	No	No	No	7	9
362	5x36	E2	endothelin_on	0	100	No	No	Yes	Yes	4	3
363	5x29	5x32	endothelin_on	0	100	No	No	No	Yes	3	4
364	5x39	5x40	endothelin_on	0	100	No	Yes	No	Yes	7	5
365	5x40	6x55	endothelin_on	0	100	No	Yes	No	Yes	5	6
366	5x42	5x43	endothelin_on	0	100	Yes	Yes	No	Yes	4	6
367	5x49	5x50	endothelin_on	0	100	No	No	No	No	6	9
368	5x54	5x58	endothelin_on	0	100	No	No	Yes	Yes	8	9
369	5x58	6x37	endothelin_on	0	100	Yes	Yes	No	No	9	8
370	5x59	6x38	endothelin_on	0	100	No	No	No	No	4	5
371	5x62	6x34	endothelin_on	0	100	No	No	No	No	5	7
372	5x66	6x31	endothelin_on	0	100	No	No	No	No	5	5
373	6x29	6x32	endothelin_on	0	100	No	No	No	No	5	7
374	6x48	6x51	endothelin_on	0	100	Yes	Yes	No	No	8	6
375	6x49	6x53	endothelin_on	0	100	No	No	No	No	5	6
376	6x50	7x37	endothelin_on	0	100	No	No	No	No	9	7
377	6x55	6x58	endothelin_on	0	100	No	Yes	No	No	6	4
378	7x29	7x33	endothelin_on	0	100	No	No	No	No	3	5
379	7x43	7x48	endothelin_on	0	100	No	No	No	No	6	6
380	1x24	NT	endothelin_on	0	100	No	No	No	Yes	4	6
381	4x38	I1x51	endothelin_on	0	100	No	No	No	No	6	7
382	2x56	7x38	endothelin_on	0	100	No	Yes	No	No	6	6
383	3x26	4x63	endothelin_on	0	100	No	No	No	No	7	5
384	3x34	4x54	endothelin_on	0	100	No	No	No	No	6	3
385	3x51	5x64	endothelin_on	0	100	No	Yes	Yes	No	8	5
386	5x30	5x33	endothelin_on	0	100	No	No	No	No	4	1
387	5x40	5x41	endothelin_on	0	100	No	Yes	No	No	5	5
388	6x28	6x31	endothelin_on	0	100	No	No	No	No	4	5
389	6x28	6x32	endothelin_on	0	100	No	No	No	No	4	7
390	6x57	6x61	endothelin_on	0	100	No	No	No	No	5	3
391	7x26	E3	endothelin_on	0	100	No	No	Yes	Yes	2	1
392	1x22	7x23	endothelin_on	0	100	No	No	No	Yes	4	5
393	1x24	1x25	endothelin_on	0	100	No	No	No	No	4	4
394	3x16	E1x49	endothelin_on	0	100	No	No	No	No	0	5
395	3x17	3x18	endothelin_on	0	100	No	No	No	No	0	0
396	3x24	3x28	endothelin_on	0	100	No	No	No	No	6	5
397	3x36	5x46	endothelin_on	0	100	No	Yes	Yes	Yes	7	5
398	5x43	5x46	endothelin_on	0	100	No	Yes	Yes	Yes	6	5
399	5x46	6x52	endothelin_on	0	100	Yes	Yes	Yes	Yes	5	8
400	7x54	8x48	endothelin_on	0	100	Yes	Yes	No	No	7	5
401	1x26	7x28	endothelin_on	0	50	No	No	No	No	5	3
402	2x42	3x49	endothelin_on	0	50	No	No	No	No	7	8
403	3x21	E1x52	endothelin_on	0	50	No	No	Yes	No	8	7
404	3x52	3x56	endothelin_on	0	50	No	No	No	No	5	7
405	3x56	I2x52	endothelin_on	0	50	No	No	No	Yes	7	5
406	2x551	3x28	endothelin_on	0	50	No	No	No	No	5	5
407	5x70	I3	endothelin_on	0	50	No	No	No	No	0	4
408	2x43	7x53	endothelin_on	0	50	No	No	No	No	8	9
409	5x68	6x27	endothelin_on	0	50	No	No	No	No	5	4
410	1x26	7x27	endothelin_on	0	50	No	No	No	No	5	3
411	6x47	7x43	endothelin_on	0	50	No	No	No	No	8	6
412	1x59	1x60	endothelin_on	0	50	No	No	No	No	4	6
413	6x24	6x25	endothelin_on	0	50	No	No	No	No	2	3
414	5x62	6x38	endothelin_on	0	50	No	No	No	No	5	5
415	1x56	8x50	endothelin_on	0	0	No	Yes	Yes	Yes	7	9
416	1x31	7x36	endothelin_on	0	50	Yes	Yes	No	No	4	5
417	5x65	5x66	endothelin_on	0	50	Yes	Yes	No	No	8	5
418	3x27	3x31	endothelin_on	0	25	No	No	No	No	5	5
419	6x47	7x40	endothelin_on	0	50	No	No	No	No	8	7
420	5x36	5x37	endothelin_on	0	0	No	No	No	No	4	4
421	3x51	5x61	endothelin_on	0	50	No	Yes	No	Yes	8	8
422	4x45	4x49	endothelin_on	0	50	No	No	No	No	6	7
423	5x45	5x48	endothelin_on	0	50	No	No	No	No	4	5
424	6x40	7x52	endothelin_on	0	25	No	No	No	No	8	7
425	1x55	1x58	endothelin_on	0	50	No	No	No	No	3	2
426	1x28	1x31	endothelin_on	0	0	No	No	Yes	Yes	3	4
427	7x48	7x51	endothelin_on	0	50	No	No	No	No	6	7
428	2x49	2x52	endothelin_on	0	50	No	No	No	No	8	7
429	3x50	5x61	endothelin_on	0	25	Yes	No	No	Yes	9	8
430	3x20	E1x52	endothelin_on	0	50	No	No	Yes	No	0	7
431	5x51	6x44	endothelin_on	0	0	No	No	Yes	Yes	7	9
432	1x32	2x64	endothelin_on	0	50	Yes	Yes	No	No	6	4
433	7x56	8x47	endothelin_on	0	50	No	No	No	No	7	8
434	1x54	2x47	endothelin_on	0	0	No	No	No	No	7	9
435	5x34	5x37	endothelin_on	0	50	No	No	No	No	1	4
436	1x52	1x56	endothelin_on	0	50	No	No	No	Yes	6	7
437	5x65	6x33	endothelin_on	0	50	Yes	Yes	No	No	8	8
438	3x16	3x17	endothelin_on	0	50	No	No	No	No	0	0
439	3x23	3x27	endothelin_on	0	50	No	No	No	No	1	5
440	1x45	1x46	endothelin_on	0	0	No	No	No	No	5	8
441	8x47	8x49	endothelin_on	0	0	No	No	No	No	8	6
442	4x64	5x32	endothelin_on	0	0	No	No	No	Yes	5	4
443	7x23	7x25	endothelin_on	0	50	No	Yes	No	No	5	4
444	6x26	I3	endothelin_on	0	25	Yes	No	No	No	4	4
445	2x41	I1x51	endothelin_on	0	25	No	No	No	No	6	7
446	4x46	4x47	endothelin_on	0	0	No	No	No	No	7	3
447	5x63	5x64	endothelin_on	0	50	No	No	Yes	No	4	5
448	4x40	4x44	endothelin_on	0	25	No	No	No	No	3	3
449	4x55	4x59	endothelin_on	0	0	No	No	No	No	4	4
450	1x44	1x47	endothelin_on	0	0	No	No	No	No	5	7
451	1x59	I1x48	endothelin_on	0	0	No	No	No	No	4	6
452	5x29	5x31	endothelin_on	0	0	No	No	No	No	3	3
453	1x30	1x31	endothelin_on	0	25	No	No	Yes	Yes	5	4
454	6x39	6x43	endothelin_on	0	0	No	No	No	No	5	6
455	I2x52	I2x55	endothelin_on	0	25	No	Yes	No	No	5	3
456	1x32	1x36	endothelin_on	0	0	Yes	Yes	Yes	No	6	6
457	8x52	8x55	endothelin_on	0	25	No	No	No	No	4	4
458	1x55	8x57	endothelin_on	0	25	No	No	No	No	3	6
459	6x25	6x29	endothelin_on	0	25	No	No	No	No	3	5
460	1x40	1x44	endothelin_on	0	0	No	No	No	No	4	5
461	1x46	1x50	endothelin_on	0	0	No	No	Yes	Yes	8	9
462	5x55	6x41	endothelin_on	0	0	No	No	No	No	5	8
463	1x47	1x51	endothelin_on	0	0	No	No	No	No	7	4
464	3x56	I2x53	endothelin_on	0	0	No	No	No	No	7	6
465	1x37	1x38	endothelin_on	0	0	No	No	No	No	6	5
466	3x53	I2x54	endothelin_on	0	0	No	No	Yes	No	8	4
467	1x37	1x41	endothelin_on	0	0	No	No	No	No	6	4
468	I1x52	I2x56	endothelin_on	0	0	No	No	No	No	8	3
469	I2x51	I2x52	endothelin_on	0	0	No	No	No	Yes	5	5
470	5x67	5x69	endothelin_on	0	0	No	No	No	No	4	0
471	5x70	5x71	endothelin_on	0	0	No	No	No	No	0	0
472	5x71	5x72	endothelin_on	0	0	No	No	No	No	0	0
473	8x56	8x57	endothelin_on	0	0	No	No	No	No	5	6
474	6x35	6x39	endothelin_on	0	0	No	No	No	No	5	5
475	1x34	1x38	endothelin_on	0	0	No	No	No	No	5	5

Orange: nodes, hubs and links specific of endothelin_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of endothelin_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	endothelin_off Avg Int. Strength	endothelin_on Avg Int. Strength	endothelin_off Num Of Links	endothelin_on Num Of Links	ConSurf
1	1x35	endothelin_off	66.6667	0	4	3	5
2	1x36	endothelin_off	0	0	4	2	6
3	1x53	endothelin_off	33.3333	0	6	3	9
4	I1x50	endothelin_off	33.3333	0	4	3	7
5	2x40	endothelin_off	0	0	4	2	8
6	2x57	endothelin_off	33.3333	0	4	3	7
7	E1x52	endothelin_off	100	50	5	3	7
8	3x29	endothelin_off	33.3333	0	4	3	5
9	3x33	endothelin_off	66.6667	50	4	3	4
10	3x50	endothelin_off	66.6667	0	4	3	9
11	I2x54	endothelin_off	0	0	4	2	4
12	4x41	endothelin_off	0	0	4	2	5
13	4x65	endothelin_off	66.6667	0	4	3	5
14	5x44	endothelin_off	66.6667	0	5	3	6
15	5x47	endothelin_off	66.6667	0	4	3	8
16	5x64	endothelin_off	0	0	4	2	5
17	6x26	endothelin_off	0	0	4	2	4
18	7x45	endothelin_off	33.3333	0	4	3	9
19	7x49	endothelin_off	0	0	4	2	9
20	8x54	endothelin_off	0	25	4	2	7
21	Lig	Shared	100	100	15	26	0
22	1x31	Shared	33.3333	0	4	5	4
23	1x32	Shared	0	0	4	4	6
24	1x50	Shared	0	50	4	5	9
25	2x46	Shared	33.3333	25	4	4	9
26	2x53	Shared	100	0	6	4	8
27	E1x50	Shared	100	100	7	5	9
28	3x30	Shared	33.3333	0	4	4	6
29	4x61	Shared	100	50	5	5	5
30	E2	Shared	100	100	13	10	3
31	5x35	Shared	66.6667	25	4	4	3
32	5x42	Shared	0	25	4	4	4
33	5x46	Shared	100	100	4	7	5
34	5x57	Shared	33.3333	0	5	4	7
35	5x58	Shared	0	50	4	5	9
36	5x65	Shared	0	25	4	4	8
37	6x44	Shared	100	0	4	4	9
38	6x48	Shared	100	100	6	8	8
39	6x52	Shared	33.3333	25	4	4	8
40	6x62	Shared	33.3333	0	5	4	2
41	E3	Shared	100	75	5	6	1
42	7x35	Shared	100	75	4	4	3
43	7x54	Shared	0	0	4	5	7
44	8x50	Shared	66.6667	25	6	5	9
45	NT	endothelin_on	33.3333	50	2	7	6
46	1x56	endothelin_on	0	0	3	4	7
47	2x50	endothelin_on	33.3333	75	3	4	9
48	2x56	endothelin_on	33.3333	25	2	4	6
49	3x36	endothelin_on	0	0	3	4	7
50	3x51	endothelin_on	0	50	2	5	8
51	I2x52	endothelin_on	0	0	2	4	5
52	5x32	endothelin_on	33.3333	0	3	4	4
53	5x39	endothelin_on	33.3333	0	3	4	7
54	5x40	endothelin_on	0	0	1	4	5
55	5x43	endothelin_on	33.3333	50	3	4	6
56	5x61	endothelin_on	0	0	2	4	8
57	6x55	endothelin_on	0	50	3	4	6
58	7x23	endothelin_on	33.3333	50	3	6	5

Orange: nodes, hubs and links specific of endothelin_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of endothelin_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	endothelin_off Recurrence	endothelin_on Recurrence	endothelin_off Hub1?	endothelin_on Hub1?	endothelin_off Hub2?	endothelin_on Hub2?	ConSurf1	ConSurf2
1	2x53	Lig	endothelin_off	33.7187	0	Yes	Yes	Yes	Yes	8	0
2	2x60	Lig	endothelin_off	36.2348	1.36975	No	No	Yes	Yes	7	0
3	2x63	Lig	endothelin_off	64.3825	0	No	No	Yes	Yes	5	0
4	3x36	Lig	endothelin_off	32.8451	0	No	Yes	Yes	Yes	7	0
5	6x52	Lig	endothelin_off	15.6458	0	Yes	Yes	Yes	Yes	8	0
6	2x63	E1x50	endothelin_off	63.3049	1.23562	No	No	Yes	Yes	5	9
7	E1x50	E2	endothelin_off	46.7594	0	Yes	Yes	Yes	Yes	9	3
8	E2	NT	endothelin_off	29.989	0.499939	Yes	Yes	No	Yes	3	6
9	7x24	NT	endothelin_off	28.6708	1.29253	No	No	No	Yes	8	6
10	6x62	7x27	endothelin_off	11.5656	0.117872	Yes	Yes	No	No	2	3
11	6x62	7x23	endothelin_off	22.5088	0.0609682	Yes	Yes	No	Yes	2	5
12	7x23	7x24	endothelin_off	27.3578	0	No	Yes	No	No	5	8
13	1x35	2x64	endothelin_off	21.0598	0	Yes	No	No	No	5	4
14	2x60	2x64	endothelin_off	34.9166	0	No	No	No	No	7	4
15	1x36	2x64	endothelin_off	13.4174	0	Yes	No	No	No	6	4
16	2x53	2x57	endothelin_off	11.8429	0	Yes	Yes	Yes	No	8	7
17	1x42	7x42	endothelin_off	10.1323	1.28846	No	No	No	No	8	7
18	7x42	Lig	endothelin_off	11.7853	0	No	No	Yes	Yes	7	0
19	2x46	7x49	endothelin_off	39.7709	3.84912	Yes	Yes	Yes	No	9	9
20	7x45	7x49	endothelin_off	100	0	Yes	No	Yes	No	9	9
21	6x48	7x45	endothelin_off	97.4578	7.37309	Yes	Yes	Yes	No	8	9
22	6x40	7x53	endothelin_off	82.9053	0	No	No	No	No	8	9
23	6x40	7x49	endothelin_off	83.4545	2.57286	No	No	Yes	No	8	9
24	8x50	8x54	endothelin_off	21.8915	0	Yes	Yes	Yes	No	9	7
25	3x38	4x50	endothelin_off	20.5315	3.84912	No	No	No	No	7	9
26	3x38	4x53	endothelin_off	23.534	2.57286	No	No	No	No	7	8
27	3x41	4x53	endothelin_off	26.4947	0	No	No	No	No	6	8
28	3x41	4x49	endothelin_off	27.9594	1.28846	No	No	No	No	6	7
29	3x42	4x49	endothelin_off	29.4136	7.62915	No	No	No	No	8	7
30	2x40	8x50	endothelin_off	61.8089	0	Yes	No	Yes	Yes	8	9
31	I1x52	I2x54	endothelin_off	44.4421	0	No	No	Yes	No	8	4
32	2x39	3x50	endothelin_off	16.8332	0	No	No	Yes	No	8	9
33	2x40	3x50	endothelin_off	23.1051	0	Yes	No	Yes	No	8	9
34	2x45	4x50	endothelin_off	11.2727	0	No	No	No	No	9	9
35	2x53	2x56	endothelin_off	15.1697	1.11775	Yes	Yes	No	Yes	8	6
36	2x56	3x31	endothelin_off	13.522	0	No	Yes	No	No	6	5
37	3x36	5x461	endothelin_off	43.1239	0.829167	No	Yes	No	No	7	6
38	5x42	5x461	endothelin_off	21.065	0	Yes	Yes	No	No	4	6
39	4x56	5x42	endothelin_off	21.9909	1.43885	No	No	Yes	Yes	5	4
40	4x52	4x56	endothelin_off	39.3158	4.38564	No	No	No	No	4	5
41	4x48	4x52	endothelin_off	37.9976	2.19485	No	No	No	No	3	4
42	4x44	4x48	endothelin_off	36.8991	0	No	No	No	No	3	3
43	4x41	4x44	endothelin_off	35.8634	2.57286	Yes	No	No	No	5	3
44	3x52	4x41	endothelin_off	25.7415	0	No	No	Yes	No	5	5
45	3x48	3x52	endothelin_off	28.1896	0	No	No	No	No	6	5
46	3x48	5x57	endothelin_off	25.6787	1.28846	No	No	Yes	Yes	6	7
47	5x46	5x461	endothelin_off	20.9709	0.459294	Yes	Yes	No	No	5	6
48	4x56	5x46	endothelin_off	19.2865	5.03191	No	No	Yes	Yes	5	5
49	2x39	3x49	endothelin_off	14.631	0	No	No	No	No	8	8
50	5x64	I2x54	endothelin_off	41.4657	0	Yes	No	Yes	No	5	4
51	5x64	5x68	endothelin_off	37.8145	0	Yes	No	No	No	5	5
52	5x68	6x30	endothelin_off	26.5784	2.39402	No	No	No	No	5	7
53	5x65	6x30	endothelin_off	18.3606	3.6459	Yes	Yes	No	No	8	7
54	5x68	I2x50	endothelin_off	10.1271	0	No	No	No	No	5	8
55	4x61	5x35	endothelin_off	11.8899	6.53985	Yes	Yes	Yes	Yes	5	3
56	5x44	6x52	endothelin_off	16.6606	3.98325	Yes	No	Yes	Yes	6	8
57	5x44	6x56	endothelin_off	11.4139	0	Yes	No	No	No	6	6
58	5x47	6x52	endothelin_off	12.9571	3.98325	Yes	No	Yes	Yes	8	8
59	5x65	6x34	endothelin_off	13.9143	0	Yes	Yes	No	No	8	7
60	5x58	6x34	endothelin_off	12.4078	0	Yes	Yes	No	No	9	7
61	8x47	8x50	endothelin_off	15.6405	4.94655	No	No	Yes	Yes	8	9
62	7x54	8x54	endothelin_off	12.7583	8.68187	Yes	Yes	Yes	No	7	7
63	6x48	Lig	Shared	83.4807	80.9454	Yes	Yes	Yes	Yes	8	0
64	1x50	2x50	Shared	11.1001	90.3426	Yes	Yes	No	Yes	9	9
65	7x53	8x50	Shared	74.1016	58.4075	No	No	Yes	Yes	9	9
66	2x46	3x42	Shared	30.8574	18.5303	Yes	Yes	No	No	9	8
67	2x40	I1x52	Shared	48.0986	13.7666	Yes	No	No	No	8	8
68	3x49	3x52	Shared	11.4348	11.1531	No	No	No	No	8	5
69	4x60	5x35	Shared	10.4985	17.4572	No	No	Yes	Yes	8	3
70	3x36	6x48	Shared	11.4453	10.1532	No	Yes	Yes	Yes	7	8
71	6x48	6x52	Shared	15.7347	15.7867	Yes	Yes	Yes	Yes	8	8
72	7x35	Lig	endothelin_on	0	22.9647	Yes	Yes	Yes	Yes	3	0
73	2x54	2x57	endothelin_on	0	11.336	No	No	Yes	No	6	7
74	2x54	7x46	endothelin_on	1.73667	12.5554	No	No	No	No	6	9
75	2x50	7x46	endothelin_on	0	13.7666	No	Yes	No	No	9	9
76	2x46	2x50	endothelin_on	9.89695	95.2038	Yes	Yes	No	Yes	9	9
77	2x46	3x43	endothelin_on	0	99.8374	Yes	Yes	No	No	9	8
78	3x43	6x44	endothelin_on	1.77329	100	No	No	Yes	Yes	8	9
79	6x44	6x48	endothelin_on	4.13768	94.0454	Yes	Yes	Yes	Yes	9	8
80	1x53	2x47	endothelin_on	4.66077	85.6684	Yes	No	No	No	9	9
81	1x50	2x47	endothelin_on	4.2266	86.6683	Yes	Yes	No	No	9	9
82	1x53	8x50	endothelin_on	9.9388	84.0467	Yes	No	Yes	Yes	9	9
83	8x50	I1x50	endothelin_on	4.8177	24.9319	Yes	Yes	Yes	No	9	7
84	1x56	8x50	endothelin_on	0	14.2584	No	Yes	Yes	Yes	7	9
85	2x40	I1x50	endothelin_on	1.47513	14.9697	Yes	No	Yes	No	8	7
86	2x39	I1x52	endothelin_on	0	10.1085	No	No	No	No	8	8
87	2x42	3x46	endothelin_on	1.41759	14.738	No	No	No	No	7	9
88	2x43	3x46	endothelin_on	0	56.676	No	No	No	No	8	9
89	2x43	7x53	endothelin_on	0	57.5174	No	No	No	No	8	9
90	2x45	3x42	endothelin_on	0	10.1085	No	No	No	No	9	8
91	2x551	3x28	endothelin_on	0	12.2668	No	No	No	No	5	5
92	3x28	3x29	endothelin_on	3.46812	18.0141	No	No	Yes	No	5	5
93	3x29	4x61	endothelin_on	5.67558	19.0465	Yes	No	Yes	Yes	5	5
94	3x33	4x61	endothelin_on	5.1891	24.2735	Yes	No	Yes	Yes	4	5
95	3x33	Lig	endothelin_on	5.74358	24.7084	Yes	No	Yes	Yes	4	0
96	5x43	Lig	endothelin_on	5.79066	16.0753	No	Yes	Yes	Yes	6	0
97	3x51	5x61	endothelin_on	0	13.7666	No	Yes	No	Yes	8	8
98	3x50	5x61	endothelin_on	0	34.2682	Yes	No	No	Yes	9	8
99	3x46	3x50	endothelin_on	0	44.9173	No	No	Yes	No	9	9
100	3x50	5x58	endothelin_on	0	12.2058	Yes	No	Yes	Yes	9	9
101	2x42	3x49	endothelin_on	0	12.3643	No	No	No	No	7	8
102	4x59	4x60	endothelin_on	5.25187	13.1041	No	No	No	No	4	8
103	5x35	5x42	endothelin_on	4.6817	12.9578	Yes	Yes	Yes	Yes	3	4
104	E2	Lig	endothelin_on	0	14.9413	Yes	Yes	Yes	Yes	3	0
105	5x61	5x65	endothelin_on	1.57975	19.8959	No	Yes	Yes	Yes	8	8
106	5x65	5x66	endothelin_on	0	14.3235	Yes	Yes	No	No	8	5
107	5x66	6x31	endothelin_on	0	13.1082	No	No	No	No	5	5
108	6x28	6x32	endothelin_on	0	10.8483	No	No	No	No	4	7
109	6x28	6x31	endothelin_on	0	12.0676	No	No	No	No	4	5
110	6x47	7x45	endothelin_on	1.61636	12.5554	No	No	Yes	No	8	9

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
2x53	Lig	endothelin_off	11.43	0	1	1	1	0
2x60	Lig	Shared	5.92	8.1425	0	1	1	0
2x63	Lig	endothelin_off	5.05333	0	0	0	1	0
3x29	Lig	endothelin_off	4.94667	0	1	1	1	0
3x32	Lig	Shared	20.8633	6.9875	1	1	1	0
3x33	Lig	Shared	14.27	9.28	1	1	1	0
3x36	Lig	endothelin_off	4.68333	0	1	1	1	0
4x65	Lig	endothelin_off	4.31	0	1	1	1	0
5x43	Lig	Shared	9.39667	5.41	1	1	1	0
6x48	Lig	Shared	13.2	4.2175	1	1	1	0
6x51	Lig	Shared	5.78333	10.68	1	1	1	0
6x52	Lig	endothelin_off	4.93667	0	1	1	1	0
6x55	Lig	Shared	9.92333	18.835	1	1	1	0
7x38	Lig	Shared	8.03	4.4175	0	1	1	0
E2	NT	Shared	4.59	12.745	2	1	1	1
7x24	NT	Shared	4.85333	3.64	0	0	2	1
1x24	7x27	endothelin_off	4.37667	0	0	1	2	1
1x27	7x31	Shared	3.80667	3.2125	0	0	2	1
1x28	7x35	endothelin_off	5.57333	0	0	0	2	1
1x31	1x35	endothelin_off	5.64	0	4	0	2	2
1x31	7x35	Shared	18.2267	2.58	4	0	2	1
1x32	E1	endothelin_off	3.6	0	0	2	2	1
1x35	2x64	endothelin_off	3.66	0	4	1	2	2
1x35	7x35	Shared	5.03667	11.335	4	1	2	1
1x42	7x42	Shared	5.38333	5.8675	0	0	2	1
2x53	2x56	Shared	8.67333	9.3825	1	1	1	2
2x53	2x57	endothelin_off	3.53333	0	1	1	1	2
2x53	3x32	endothelin_off	5.77	0	1	1	1	1
2x53	3x35	Shared	5.11	3.0125	1	1	1	2
2x53	7x46	endothelin_off	5.11333	0	1	1	1	2
2x59	E1x52	endothelin_off	12.14	0	0	0	1	2
2x59	3x28	endothelin_off	5.63333	0	0	0	1	2
2x63	E1x50	Shared	6.96	6.09	0	0	1	1
E1x49	E2	Shared	17.4033	3.3175	0	1	2	1
E1x50	E1x51	Shared	3.6	5.405	2	1	1	2
E1x50	E1x52	endothelin_off	13.3633	0	2	1	1	2
3x25	E1x50	Shared	8.27333	5.8775	2	1	2	1
E1x50	E2	endothelin_off	4.30667	0	2	1	1	1
E1x50	E2x50	Shared	8.70667	14.365	2	1	1	2
E1x51	E1x52	endothelin_off	9.63	0	2	0	2	2
3x25	E2x50	Shared	7.28	6.37	2	1	2	2
3x26	E2	endothelin_off	5.99333	0	0	0	2	1
3x28	3x29	Shared	3.53	2.9275	0	0	2	1
3x29	4x61	Shared	5.76333	5.5025	1	1	1	2
3x29	4x65	Shared	15.41	8.305	1	1	1	1
3x32	3x33	Shared	8.13667	3.73	1	1	1	1
3x33	4x61	Shared	11.7	12.15	1	1	1	2
3x33	5x43	endothelin_off	4.7	0	1	1	1	1
3x36	5x461	Shared	4.20667	3.155	1	1	1	2
3x36	6x48	Shared	6.95	5.21	1	1	1	1
4x61	4x65	Shared	7.77333	6.7025	1	1	2	1
4x61	5x39	Shared	8.55	5.4	1	1	2	2
4x64	E2	endothelin_off	4.38333	0	0	0	2	1
4x65	E2x52	Shared	7.71333	10.05	1	1	1	2
E2	E2	Shared	59.39	69.01	2	1	1	1
E2	E2x50	endothelin_off	5.45667	0	2	1	1	2
E2	E2x51	Shared	9.04	6.5775	2	1	1	1
5x32	E2	Shared	10.8767	6.37	2	1	2	1
5x33	E2	Shared	6.93	1.395	2	1	2	1
5x29	E2	endothelin_off	4.00333	0	0	0	2	1
5x39	5x43	Shared	5.64	5.2875	1	1	2	1
5x42	5x46	Shared	14.03	9.52	1	1	2	2
5x42	5x461	endothelin_off	4.18	0	1	1	2	2
5x44	5x47	Shared	6.07	8.5725	1	1	2	2
5x44	6x52	Shared	8.29667	8.2025	1	1	2	1
5x46	5x461	Shared	13.0633	3.61	1	1	2	2
5x47	6x52	Shared	17.3467	11.0275	1	1	2	1
6x44	6x48	Shared	14.6967	5.51	1	1	2	1
6x44	7x45	Shared	6.04	8.46	1	1	2	2
6x48	6x52	Shared	6.34667	3.1775	1	1	1	1
6x48	7x41	Shared	8.64667	9.0775	1	1	1	2
6x48	7x45	Shared	6.78	4.2375	1	1	1	2
6x51	6x55	endothelin_off	4.05	0	1	1	1	1
6x51	7x37	endothelin_off	3.99	0	1	1	1	2
6x54	7x34	Shared	4.11667	9.57	0	0	2	1
6x55	7x34	Shared	9.13	5.0625	1	1	1	1
6x62	E3	Shared	10.9067	5.2825	7	1	1	1
6x62	7x23	Shared	4.8	4.115	7	1	1	1
6x62	7x27	Shared	9.76667	3.5175	7	1	1	1
E3	E3	Shared	15.8133	18.8725	7	1	1	1
7x23	E3	Shared	7.03667	7.8025	7	1	1	1
7x25	E3	endothelin_off	7.88667	0	0	0	2	1
7x31	7x35	endothelin_off	7.42333	0	0	1	1	1
7x23	7x24	endothelin_off	3.25	0	7	1	1	2
6x58	6x62	endothelin_off	3.18333	0	0	1	1	1
6x62	7x26	endothelin_off	3.12667	0	7	1	1	2
2x60	2x64	endothelin_off	2.74667	0	0	1	1	2
3x22	E2	Shared	2.62333	1.5625	0	0	2	1
7x42	Lig	endothelin_off	2.14	0	0	0	1	0
5x36	E2x52	endothelin_off	1.57667	0	0	1	1	2
3x21	E1x50	endothelin_off	1.40667	0	0	0	2	1
1x22	1x25	endothelin_off	1.37	0	0	0	2	1
1x25	1x26	endothelin_off	1.36667	0	0	1	1	2
5x33	5x37	endothelin_off	0.946667	0	2	1	2	2
6x58	Lig	endothelin_on	0	7.4875	0	1	1	0
5x36	Lig	endothelin_on	0	6.9225	0	1	1	0
E2	Lig	endothelin_on	0	55.4075	2	1	1	0
E3	Lig	endothelin_on	0	8.9975	7	1	1	0
6x62	Lig	endothelin_on	0	4.255	7	1	1	0
7x23	Lig	endothelin_on	0	4.3675	7	1	1	0
Lig	NT	endothelin_on	0	4.05	1	1	0	1
7x27	Lig	endothelin_on	0	9.2675	0	1	1	0
1x25	Lig	endothelin_on	0	4.4575	0	1	1	0
7x31	Lig	endothelin_on	0	10.355	0	1	1	0
7x34	Lig	endothelin_on	0	15.32	0	1	1	0
E2x51	Lig	endothelin_on	0	5.9525	0	1	1	0
E1	Lig	endothelin_on	0	4.2525	0	0	1	0
7x35	Lig	endothelin_on	0	4.205	4	1	1	0
2x59	Lig	endothelin_on	0	3.6775	0	0	1	0
E1x50	Lig	endothelin_on	0	3.5225	2	1	1	0
NT	NT	endothelin_on	0	5.285	2	1	1	1
7x23	NT	endothelin_on	0	5.92	7	1	1	1
2x53	3x36	endothelin_on	0	3.3375	1	1	1	1
2x53	6x48	endothelin_on	0	4.9625	1	1	1	1
2x56	2x60	endothelin_on	0	6.7325	0	1	2	1
2x56	3x32	endothelin_on	0	16.6425	0	1	2	1
2x57	7x42	endothelin_on	0	4.4975	1	0	2	1
2x60	7x38	endothelin_on	0	6.37	0	1	1	1
2x64	7x35	endothelin_on	0	18.4625	0	0	2	1
E1x49	E1x51	endothelin_on	0	4.4275	0	1	2	2
5x36	E2	endothelin_on	0	3.71	0	1	1	1
5x29	5x32	endothelin_on	0	4.5475	0	0	2	2
5x39	5x40	endothelin_on	0	3.4575	1	1	2	2
5x40	6x55	endothelin_on	0	8.04	0	0	2	1
5x42	5x43	endothelin_on	0	3.99	1	1	2	1
6x48	6x51	endothelin_on	0	5.1225	1	1	1	1
6x55	6x58	endothelin_on	0	8.0425	1	1	1	1
1x24	NT	endothelin_on	0	4.415	0	1	2	1
2x56	7x38	endothelin_on	0	3.5	0	1	2	1
7x26	E3	endothelin_on	0	3.7775	0	1	2	1
1x22	7x23	endothelin_on	0	6.485	0	0	2	1
1x24	1x25	endothelin_on	0	4.25	0	1	2	1
3x36	5x46	endothelin_on	0	6.31	1	1	1	2
5x43	5x46	endothelin_on	0	5.86	1	1	1	2
5x46	6x52	endothelin_on	0	4.355	1	1	2	1
3x21	E1x52	endothelin_on	0	3.0125	0	0	2	2
1x26	7x27	endothelin_on	0	2.82	0	0	2	1
5x36	5x37	endothelin_on	0	2.43	0	1	1	2
1x28	1x31	endothelin_on	0	2.225	0	0	2	2
1x32	2x64	endothelin_on	0	2.115	0	2	2	2
4x64	5x32	endothelin_on	0	1.75	0	0	2	2
7x23	7x25	endothelin_on	0	1.745	7	1	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	endothelin_off	etb_off
	endothelin_on	etb_on eta_on

Network Difference
Value	endothelin_off	endothelin_on
I_min	3.52667	3.115
Number of Linked Nodes	279	290
Number of Specific Nodes	1 (0.36%)	12 (4.14%)
Number of Shared Nodes	278 (99.64%)	278 (95.86%)
Number of Links	317	328
Number of Specific Links	147 (46.37%)	158 (48.17%)
Number of Shared Links	170 (53.63%)	170 (51.83%)
Number of Hubs	44	38
Number of Specific Hubs	20 (45.45%)	14 (36.84%)
Number of Shared Hubs	24 (54.55%)	24 (63.16%)
Average % Shared Neighbours (Jaccard)	37.20
Average % Shared Neighbours (Otsuka)	47.61
Average % Shared Neighbours (Overlap Coefficient)	57.94
Average % Shared Cliques (k3-6)	54.55
Graphlets Similarity	0.623718

Paths Difference
Value	endothelin_off	endothelin_on
Number Of Nodes in MetaPath	70	51
Specific Nodes in MetaPath	44 (62.86%)	25 (49.02%)
Shared Nodes in MetaPath	278 (99.64%)	278 (99.64%)
Number Of Links MetaPath	71	48
Specific Links in MetaPath	62 (87.32%)	39 (81.25%)
Shared Links in MetaPath	170 (53.63%)	170 (53.63%)
Number of Shortest Paths	49359	47125
Length Of Smallest Path	3	3
Average Path Length	12.6638	13.2831
Length of Longest Path	33	36
Minimum Path Strength	0.563333	0.5775
Average Path Strength	5.84197	5.19875
Maximum Path Strength	17.0317	37.1212
Minimum Path Correlation	0.7	0.7025
Average Path Correlation	0.93063	0.928227
Maximum Path Correlation	0.99	0.9925
Minimum % Of Corr. Nodes	4.34783	3.125
Average % Of Corr. Nodes	51.5106	52.2145
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	44.9522	43.7114
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

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