Orange: nodes, hubs and links specific of endothelin_on_gp network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of endothelin_off network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.


Index Hub Owner endothelin_on_gp Avg Int. Strength endothelin_off Avg Int. Strength endothelin_on_gp Num Of Links endothelin_off Num Of Links ConSurf
1G.S1.02 endothelin_on_gp500405
2G.S1.07 endothelin_on_gp1000409
3G.H1.01 endothelin_on_gp500409
4G.H1.04 endothelin_on_gp00407
5G.S2.03 endothelin_on_gp250409
6G.S2.08 endothelin_on_gp500405
7G.S3.03 endothelin_on_gp1000407
8G.S3.04 endothelin_on_gp250406
9G.S3.06 endothelin_on_gp1000505
10G.s3h2.03 endothelin_on_gp500409
11G.H2.04 endothelin_on_gp500509
12G.H2.06 endothelin_on_gp1000809
13G.H2.07 endothelin_on_gp1000609
14G.h2s4.01 endothelin_on_gp1000609
15G.S4.02 endothelin_on_gp500408
16G.S4.03 endothelin_on_gp750407
17G.S4.04 endothelin_on_gp1000609
18G.H3.01 endothelin_on_gp500409
19G.H3.09 endothelin_on_gp500609
20G.H3.13 endothelin_on_gp500505
21G.H3.17 endothelin_on_gp750505
22G.H3.18 endothelin_on_gp750409
23G.S5.04 endothelin_on_gp1000509
24G.S5.05 endothelin_on_gp1000809
25G.S5.07 endothelin_on_gp00409
26G.s5hg.01 endothelin_on_gp00409
27G.HG.07 endothelin_on_gp500409
28G.hgh4.02 endothelin_on_gp500407
29G.hgh4.05 endothelin_on_gp00407
30G.H4.08 endothelin_on_gp500503
31G.H4.10 endothelin_on_gp250506
32G.H4.14 endothelin_on_gp500505
33G.H4.15 endothelin_on_gp750408
34G.h4s6.02 endothelin_on_gp00408
35G.h4s6.12 endothelin_on_gp500404
36G.S6.02 endothelin_on_gp1000607
37G.S6.05 endothelin_on_gp00404
38G.s6h5.01 endothelin_on_gp00409
39G.H5.05 endothelin_on_gp00405
40G.H5.08 endothelin_on_gp1000508
41G.H5.13 endothelin_on_gp00508
42G.H5.21 endothelin_on_gp00405
43b.h2x5 endothelin_on_gp00405
44b.lhb1x6 endothelin_on_gp00403
45b.b1x4 endothelin_on_gp00407
46b.l1x3 endothelin_on_gp1000509
47b.l1x6 endothelin_on_gp1000509
48b.b2x1 endothelin_on_gp1000408
49b.b2x5 endothelin_on_gp1000507
50b.l3x1 endothelin_on_gp500509
51b.l3x2 endothelin_on_gp750409
52b.b4x5 endothelin_on_gp1000407
53b.b4x6 endothelin_on_gp1000709
54b.l4x2 endothelin_on_gp500404
55b.b5x2 endothelin_on_gp250507
56b.b5x3 endothelin_on_gp1000609
57b.b5x5 endothelin_on_gp500405
58b.b5x7 endothelin_on_gp1000407
59b.l5x1 endothelin_on_gp1000508
60b.l5x5 endothelin_on_gp1000709
61b.b6x3 endothelin_on_gp00408
62b.b6x5 endothelin_on_gp1000606
63b.b7x1 endothelin_on_gp750504
64b.b7x4 endothelin_on_gp1000608
65b.b8x4 endothelin_on_gp1000606
66b.l8x1 endothelin_on_gp500405
67b.l8x3 endothelin_on_gp00403
68b.l8x5 endothelin_on_gp00403
69b.l8x8 endothelin_on_gp500404
70b.b9x3 endothelin_on_gp00406
71b.l9x6 endothelin_on_gp1000708
72b.b10x5 endothelin_on_gp1000509
73b.l10x1 endothelin_on_gp1000403
74b.b11x4 endothelin_on_gp500409
75b.l11x2 endothelin_on_gp500409
76b.b12x3 endothelin_on_gp500408
77b.b12x5 endothelin_on_gp250406
78b.b12x6 endothelin_on_gp1000508
79b.b13x7 endothelin_on_gp1000507
80b.l13x3 endothelin_on_gp1000609
81b.l13x6 endothelin_on_gp1000509
82b.l13x7 endothelin_on_gp1000509
83b.b14x1 endothelin_on_gp750508
84b.b14x3 endothelin_on_gp750405
85b.b15x1 endothelin_on_gp1000509
86b.b15x2 endothelin_on_gp1000406
87b.b15x3 endothelin_on_gp250409
88b.l15x1 endothelin_on_gp1000407
89b.l15x2 endothelin_on_gp1000509
90b.b16x4 endothelin_on_gp1000506
91b.b16x6 endothelin_on_gp1000508
92b.b17x7 endothelin_on_gp750408
93b.l17x3 endothelin_on_gp1000509
94b.l17x6 endothelin_on_gp1000609
95b.b18x3 endothelin_on_gp1000408
96b.b18x5 endothelin_on_gp500505
97b.l18x1 endothelin_on_gp1000606
98b.l18x2 endothelin_on_gp500407
99b.l18x3 endothelin_on_gp500405
100b.b19x2 endothelin_on_gp1000606
101b.b19x4 endothelin_on_gp1000508
102b.l19x2 endothelin_on_gp500409
103b.b20x2 endothelin_on_gp750406
104b.b20x4 endothelin_on_gp1000508
105b.b20x6 endothelin_on_gp500406
106b.b21x1 endothelin_on_gp750407
107b.b21x2 endothelin_on_gp750506
108b.b21x7 endothelin_on_gp1000605
109b.l21x2 endothelin_on_gp00404
110b.b22x5 endothelin_on_gp1000807
111b.l22x5 endothelin_on_gp1000609
112b.b23x6 endothelin_on_gp500507
113b.b24x2 endothelin_on_gp00405
114b.b24x4 endothelin_on_gp500506
115b.b24x6 endothelin_on_gp500408
116b.l24x3 endothelin_on_gp500505
117b.l25x3 endothelin_on_gp1000409
118b.l25x6 endothelin_on_gp500408
119b.b26x3 endothelin_on_gp1000506
120b.l26x5 endothelin_on_gp1000505
121b.b27x3 endothelin_on_gp500408
122b.l27x1 endothelin_on_gp1000809
123b.l27x2 endothelin_on_gp750509
124b.b28x3 endothelin_on_gp500507
125b.b28x4 endothelin_on_gp1000406
126b.b28x6 endothelin_on_gp1000609
127g.h1x11 endothelin_on_gp00409
128g.h2x11 endothelin_on_gp500406
129g.ctx3 endothelin_on_gp1000609
130g.ctx6 endothelin_on_gp00506
131g.ctx14 endothelin_on_gp1000509
132g.ctx16 endothelin_on_gp1000608
133NT endothelin_on_gp7533.3333826
1341x24 endothelin_on_gp00424
1352x39 endothelin_on_gp250438
1362x50 endothelin_on_gp10033.3333439
1372x56 endothelin_on_gp7533.3333426
1382x60 endothelin_on_gp250427
1393x36 endothelin_on_gp00437
1403x51 endothelin_on_gp750528
141I2x50 endothelin_on_gp500538
142I2x52 endothelin_on_gp00425
1435x32 endothelin_on_gp033.3333434
1445x36 endothelin_on_gp00414
1455x39 endothelin_on_gp5033.3333437
1465x40 endothelin_on_gp00415
1475x43 endothelin_on_gp5033.3333436
1486x29 endothelin_on_gp250415
1496x30 endothelin_on_gp500437
1506x55 endothelin_on_gp500436
1517x23 endothelin_on_gp5033.3333635
152Lig Shared10010028150
1531x31 Shared033.3333544
1541x32 Shared00446
1551x50 Shared500549
1562x46 Shared10033.3333449
1572x53 Shared25100468
1582x57 Shared5033.3333447
159E1x50 Shared100100579
1603x30 Shared5033.3333446
1613x50 Shared10066.6667449
1624x61 Shared50100555
163E2 Shared10010010133
1645x35 Shared2566.6667443
1655x42 Shared250444
1665x46 Shared100100745
1675x57 Shared5033.3333457
1685x58 Shared500549
1696x26 Shared1000644
1706x44 Shared0100449
1716x48 Shared100100868
1726x52 Shared2533.3333448
1736x62 Shared033.3333452
174E3 Shared75100851
1757x35 Shared75100443
1767x54 Shared00547
1778x50 Shared10066.6667569
1781x35 endothelin_off066.6667345
1791x36 endothelin_off00246
1801x53 endothelin_off033.3333369
181I1x50 endothelin_off033.3333247
1822x40 endothelin_off00248
183E1x52 endothelin_off50100357
1843x29 endothelin_off033.3333345
1853x33 endothelin_off5066.6667344
186I2x54 endothelin_off00144
1874x41 endothelin_off00245
1884x65 endothelin_off066.6667345
1895x44 endothelin_off5066.6667356
1905x47 endothelin_off2566.6667348
1915x64 endothelin_off00245
1925x65 endothelin_off250348
1937x45 endothelin_off033.3333349
1947x49 endothelin_off00249
1958x54 endothelin_off250147
   
Orange: nodes, hubs and links specific of endothelin_on_gp network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of endothelin_off network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Owner endothelin_on_gp Recurrence endothelin_off Recurrence endothelin_on_gp Hub1? endothelin_off Hub1? endothelin_on_gp Hub2? endothelin_off Hub2? ConSurf1 ConSurf2
1b.b3x6 b.l1x3 endothelin_on_gp11.75970NoNoYesNo99
2b.b3x6 b.l3x2 endothelin_on_gp11.85020NoNoYesNo99
3b.l1x5 b.l3x2 endothelin_on_gp12.84790NoNoYesNo79
4b.l1x5 b.l3x1 endothelin_on_gp12.93970NoNoYesNo79
5b.l3x1 b.l5x5 endothelin_on_gp29.2840YesNoYesNo99
6G.h2s4.01 b.l5x5 endothelin_on_gp36.66780YesNoYesNo99
7G.S1.05 G.h2s4.01 endothelin_on_gp36.58120NoNoYesNo99
8G.S1.05 G.S1.07 endothelin_on_gp36.49640NoNoYesNo99
9G.S1.07 G.S4.04 endothelin_on_gp70.36650YesNoYesNo99
10G.H3.09 G.S4.04 endothelin_on_gp52.11110YesNoYesNo99
11G.H3.09 G.H4.15 endothelin_on_gp51.56740YesNoYesNo98
12G.H4.15 G.S5.06 endothelin_on_gp1000YesNoNoNo88
13G.S5.06 G.s4h3.01 endothelin_on_gp99.43950NoNoNoNo87
14G.HG.04 G.s4h3.01 endothelin_on_gp99.18110NoNoNoNo97
15G.HG.04 G.s4h3.04 endothelin_on_gp98.22110NoNoNoNo98
16G.HG.07 G.s4h3.04 endothelin_on_gp98.12650YesNoNoNo98
17G.HG.07 G.s4h3.02 endothelin_on_gp97.46450YesNoNoNo99
18G.s4h3.02 G.s5hg.01 endothelin_on_gp97.13450NoNoYesNo99
19G.S5.07 G.s5hg.01 endothelin_on_gp96.22590YesNoYesNo99
20G.S5.07 G.s6h5.01 endothelin_on_gp94.27970YesNoYesNo99
21G.S5.05 G.s6h5.01 endothelin_on_gp86.04110YesNoYesNo99
22G.S4.03 G.S5.05 endothelin_on_gp72.71280YesNoYesNo79
23G.S1.04 G.S4.03 endothelin_on_gp72.3160NoNoYesNo77
24G.S1.04 G.S3.03 endothelin_on_gp36.22540NoNoYesNo77
25G.S1.02 G.S3.03 endothelin_on_gp35.88510YesNoYesNo57
26G.H5.15 G.S1.02 endothelin_on_gp71.28160NoNoYesNo75
27G.H5.15 G.H5.19 endothelin_on_gp71.04480NoNoNoNo78
283x53 G.H5.19 endothelin_on_gp70.5710NoNoNoNo88
293x53 G.H5.23 endothelin_on_gp70.3340NoNoNoNo84
303x50 G.H5.23 endothelin_on_gp65.35780YesYesNoNo94
313x46 3x50 endothelin_on_gp62.01880NoNoYesYes99
32G.S4.04 G.S5.04 endothelin_on_gp51.8830YesNoYesNo99
33G.H4.15 G.S5.04 endothelin_on_gp51.33410YesNoYesNo89
34G.H5.11 G.S1.04 endothelin_on_gp35.98430NoNoNoNo87
35G.H5.11 G.S1.02 endothelin_on_gp35.86990NoNoYesNo85
36G.H5.06 G.H5.10 endothelin_on_gp16.11090NoNoNoNo36
37G.H5.10 G.S6.02 endothelin_on_gp24.31240NoNoYesNo67
38G.H5.13 G.S6.02 endothelin_on_gp13.14330YesNoYesNo87
396x30 G.H5.13 endothelin_on_gp10.87250YesNoYesNo78
40b.b2x1 b.l27x1 endothelin_on_gp16.94980YesNoYesNo89
41b.b26x1 b.l27x1 endothelin_on_gp17.88190NoNoYesNo99
42b.b26x1 b.b26x2 endothelin_on_gp17.72660NoNoNoNo97
43b.b26x2 b.b2x3 endothelin_on_gp17.57360NoNoNoNo76
44G.H2.04 b.l17x6 endothelin_on_gp64.81730YesNoYesNo99
452x43 7x53 endothelin_on_gp58.42970NoNoNoNo89
462x43 3x46 endothelin_on_gp58.66930NoNoNoNo89
47b.b19x5 b.l21x9 endothelin_on_gp12.29850NoNoNoNo56
48b.b19x4 b.b19x5 endothelin_on_gp12.39550YesNoNoNo85
49b.b2x5 b.l4x1 endothelin_on_gp12.24550YesNoNoNo75
50b.b18x3 b.b19x4 endothelin_on_gp17.34220YesNoYesNo88
51b.b15x2 b.b18x3 endothelin_on_gp17.10410YesNoYesNo68
52b.b15x2 b.b16x5 endothelin_on_gp31.73990YesNoNoNo65
53b.b16x5 b.l14x6 endothelin_on_gp46.72630NoNoNoNo53
54b.l14x5 b.l14x6 endothelin_on_gp45.15050NoNoNoNo53
55b.l14x5 b.l16x2 endothelin_on_gp44.5260NoNoNoNo59
56b.l16x1 b.l16x2 endothelin_on_gp44.22870NoNoNoNo49
57b.l10x1 b.l16x1 endothelin_on_gp14.83160YesNoNoNo34
58b.b14x5 b.l10x1 endothelin_on_gp13.57360NoNoYesNo53
59b.b12x5 b.l16x1 endothelin_on_gp29.09440YesNoNoNo64
60b.b14x5 b.b15x1 endothelin_on_gp12.34480NoNoYesNo59
61b.b12x5 b.b13x5 endothelin_on_gp18.97650YesNoNoNo64
62b.b13x5 b.b13x7 endothelin_on_gp18.7140NoNoYesNo47
63b.b15x1 b.b16x6 endothelin_on_gp10.76180YesNoYesNo98
64b.b13x7 b.b16x6 endothelin_on_gp10.78330YesNoYesNo78
65b.b19x2 b.b20x6 endothelin_on_gp31.60930YesNoYesNo66
66b.b19x2 b.l20x1 endothelin_on_gp15.90680YesNoNoNo66
67b.l17x5 b.l17x6 endothelin_on_gp64.12090NoNoYesNo69
68b.l17x5 b.l19x2 endothelin_on_gp64.02540NoNoYesNo69
69b.b19x6 b.l19x2 endothelin_on_gp26.92840NoNoYesNo99
70b.b19x6 b.l17x3 endothelin_on_gp26.82850NoNoYesNo99
71b.b19x4 b.l17x3 endothelin_on_gp26.46270YesNoYesNo89
72b.b20x2 b.l19x2 endothelin_on_gp36.9070YesNoYesNo69
73b.b20x2 b.b20x4 endothelin_on_gp36.60760YesNoYesNo68
741x53 8x50 endothelin_on_gp55.30379.9388NoYesYesYes99
751x53 2x47 endothelin_on_gp54.58254.66077NoYesNoNo99
761x50 2x47 endothelin_on_gp54.10154.2266YesYesNoNo99
772x46 2x50 endothelin_on_gp49.03799.89695YesYesYesNo99
782x46 3x43 endothelin_on_gp44.4360YesYesNoNo98
793x43 6x44 endothelin_on_gp44.19331.77329NoNoYesYes89
806x44 6x48 endothelin_on_gp40.74074.13768YesYesYesYes98
81G.H2.04 G.H3.08 endothelin_on_gp33.6730YesNoNoNo99
82b.b2x5 b.b3x2 endothelin_on_gp11.0330YesNoNoNo75
83b.l4x1 g.ctx16 endothelin_on_gp10.76780NoNoYesNo58
84b.b20x4 b.b20x6 endothelin_on_gp36.33050YesNoYesNo86
85b.b15x2 b.b19x2 endothelin_on_gp15.88990YesNoYesNo66
86b.b16x5 b.l20x1 endothelin_on_gp15.29830NoNoNoNo56
87G.H2.04 G.S1.07 endothelin_on_gp33.74160YesNoYesNo99
88G.H3.08 G.S4.04 endothelin_on_gp33.66360NoNoYesNo99
897x53 8x50 Shared57.205674.1016NoNoYesYes99
901x50 2x50 Shared52.175311.1001YesYesYesNo99
916x48 Lig Shared30.181483.4807YesYesYesYes80
922x53 Lig endothelin_off033.7187YesYesYesYes80
932x60 Lig endothelin_off0.24657336.2348YesNoYesYes70
942x63 Lig endothelin_off0.2443264.3825NoNoYesYes50
953x36 Lig endothelin_off032.8451YesNoYesYes70
966x52 Lig endothelin_off015.6458YesYesYesYes80
972x63 E1x50 endothelin_off0.00024144963.3049NoNoYesYes59
98E1x50 E2 endothelin_off046.7594YesYesYesYes93
99E2 NT endothelin_off0.0056606429.989YesYesYesNo36
1007x24 NT endothelin_off0.25231428.6708NoNoYesNo86
1016x62 7x27 endothelin_off0.00085848611.5656YesYesNoNo23
1026x62 7x23 endothelin_off0.0003487622.5088YesYesYesNo25
1037x23 7x24 endothelin_off027.3578YesNoNoNo58
1041x35 2x64 endothelin_off021.0598NoYesNoNo54
1052x60 2x64 endothelin_off034.9166YesNoNoNo74
1061x36 2x64 endothelin_off013.4174NoYesNoNo64
1072x53 2x57 endothelin_off011.8429YesYesYesYes87
1081x42 7x42 endothelin_off0.25231410.1323NoNoNoNo87
1097x42 Lig endothelin_off011.7853NoNoYesYes70
1102x46 7x49 endothelin_off0.75683639.7709YesYesNoYes99
1117x45 7x49 endothelin_off0100NoYesNoYes99
1126x48 7x45 endothelin_off0.048665497.4578YesYesNoYes89
1136x40 7x53 endothelin_off082.9053NoNoNoNo89
1146x40 7x49 endothelin_off0.50460283.4545NoNoNoYes89
1158x50 8x54 endothelin_off021.8915YesYesNoYes97
1163x38 4x50 endothelin_off0.75683620.5315NoNoNoNo79
1173x38 4x53 endothelin_off0.50460223.534NoNoNoNo78
1183x41 4x53 endothelin_off026.4947NoNoNoNo68
1193x41 4x49 endothelin_off0.25231427.9594NoNoNoNo67
1203x42 4x49 endothelin_off1.5132229.4136NoNoNoNo87
1212x46 3x42 endothelin_off3.7794630.8574YesYesNoNo98
1222x40 8x50 endothelin_off061.8089NoYesYesYes89
1232x40 I1x52 endothelin_off2.255448.0986NoYesNoNo88
124I1x52 I2x54 endothelin_off044.4421NoNoNoYes84
1252x39 3x50 endothelin_off016.8332YesNoYesYes89
1262x40 3x50 endothelin_off023.1051NoYesYesYes89
1272x45 4x50 endothelin_off011.2727NoNoNoNo99
1282x53 2x56 endothelin_off0.25118815.1697YesYesYesNo86
1292x56 3x31 endothelin_off013.522YesNoNoNo65
1303x36 5x461 endothelin_off0.24300543.1239YesNoNoNo76
1315x42 5x461 endothelin_off021.065YesYesNoNo46
1324x56 5x42 endothelin_off0.0095506521.9909NoNoYesYes54
1334x52 4x56 endothelin_off1.0041939.3158NoNoNoNo45
1344x48 4x52 endothelin_off0.50210737.9976NoNoNoNo34
1354x44 4x48 endothelin_off036.8991NoNoNoNo33
1364x41 4x44 endothelin_off0.50460235.8634NoYesNoNo53
1373x52 4x41 endothelin_off025.7415NoNoNoYes55
1383x48 3x52 endothelin_off028.1896NoNoNoNo65
1393x48 5x57 endothelin_off0.38940425.6787NoNoYesYes67
1405x46 5x461 endothelin_off0.0032193220.9709YesYesNoNo56
1414x56 5x46 endothelin_off1.4966419.2865NoNoYesYes55
1423x49 3x52 endothelin_off2.5217711.4348NoNoNoNo85
1432x39 3x49 endothelin_off014.631YesNoNoNo88
1445x64 I2x54 endothelin_off041.4657NoYesNoYes54
1455x64 5x68 endothelin_off037.8145NoYesNoNo55
1465x68 6x30 endothelin_off0.76751326.5784NoNoYesNo57
1475x65 6x30 endothelin_off5.4471218.3606NoYesYesNo87
1485x68 I2x50 endothelin_off010.1271NoNoYesNo58
1494x61 5x35 endothelin_off1.262311.8899YesYesYesYes53
1504x60 5x35 endothelin_off4.9915310.4985NoNoYesYes83
1515x44 6x52 endothelin_off0.7575616.6606NoYesYesYes68
1525x44 6x56 endothelin_off011.4139NoYesNoNo66
1535x47 6x52 endothelin_off0.7575612.9571NoYesYesYes88
1545x65 6x34 endothelin_off013.9143NoYesNoNo87
1555x58 6x34 endothelin_off012.4078YesYesNoNo97
1568x47 8x50 endothelin_off0.75675515.6405NoNoYesYes89
1577x54 8x54 endothelin_off0.37872612.7583YesYesNoYes77
1583x36 6x48 endothelin_off3.7104811.4453YesNoYesYes78
1596x48 6x52 endothelin_off4.9809115.7347YesYesYesYes88

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Midway



Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Node1Node2OwnerNet1LinkStrengthNet2LinkStrengthComm1Comm2Node1ShellNode2Shell
2x53Ligendothelin_off11.4301110
2x60LigShared5.928.14250110
2x63LigShared5.053332.9050110
3x29Ligendothelin_off4.9466701110
3x32LigShared20.86336.98751110
3x33LigShared14.279.281110
3x36Ligendothelin_off4.6833301110
4x65Ligendothelin_off4.3101110
5x43LigShared9.396675.411110
6x48LigShared13.24.21751110
6x51LigShared5.7833310.681110
6x52Ligendothelin_off4.9366701110
6x55LigShared9.9233318.8351110
7x38LigShared8.034.41750110
E2NTShared4.5912.7452111
7x24NTShared4.853333.640021
1x231x24Shared4.062.030021
1x247x27endothelin_off4.3766700111
1x277x31Shared3.806673.21250021
1x287x35endothelin_off5.5733300021
1x311x35endothelin_off5.6404022
1x317x35Shared18.22672.584021
1x32E1endothelin_off3.6002421
1x352x64endothelin_off3.6604122
1x357x35Shared5.0366711.3354121
1x427x42Shared5.383335.86750021
2x532x56Shared8.673339.38251112
2x532x57endothelin_off3.5333301112
2x533x32endothelin_off5.7701111
2x533x35Shared5.113.01251112
2x537x46endothelin_off5.1133301112
2x547x46Shared5.162.357501622
2x59E1x52endothelin_off12.1400112
2x593x28endothelin_off5.6333300112
2x63E1x50Shared6.966.090111
E1x49E2Shared17.40333.31750121
E1x50E1x51Shared3.65.4052112
E1x50E1x52endothelin_off13.363302112
3x25E1x50Shared8.273335.87752121
E1x50E2endothelin_off4.3066702111
E1x50E2x50Shared8.7066714.3652112
E1x51E1x52endothelin_off9.6302022
3x25E2x50Shared7.286.372122
3x26E2endothelin_off5.9933300021
3x283x29Shared3.532.92750021
3x294x61Shared5.763335.50251112
3x294x65Shared15.418.3051111
3x323x33Shared8.136673.731111
3x334x61Shared11.712.151112
3x335x43endothelin_off4.701111
3x365x461Shared4.206673.1551112
3x366x48Shared6.955.211111
4x614x65Shared7.773336.70251121
4x615x39Shared8.555.41122
4x64E2endothelin_off4.3833300021
4x65E2x52Shared7.7133310.051112
E2E2Shared59.3969.012111
E2E2x50endothelin_off5.4566702112
E2E2x51Shared9.046.57752111
5x32E2Shared10.87676.372121
5x33E2Shared6.931.3952121
5x29E2endothelin_off4.0033300021
5x395x43Shared5.645.28751121
5x425x46Shared14.039.521122
5x425x461endothelin_off4.1801122
5x445x47Shared6.078.57251122
5x446x52Shared8.296678.20251121
5x465x461Shared13.06333.611122
5x476x52Shared17.346711.02751121
6x446x48Shared14.69675.511121
6x447x45Shared6.048.461122
6x486x52Shared6.346673.17751111
6x487x41Shared8.646679.07751112
6x487x45Shared6.784.23751112
6x516x55endothelin_off4.0501111
6x517x37endothelin_off3.9901112
6x547x34Shared4.116679.570021
6x557x34Shared9.135.06251111
6x62E3Shared10.90675.28257111
6x627x23Shared4.84.1157111
6x627x27Shared9.766673.51757111
E3E3Shared15.813318.87257111
7x23E3Shared7.036677.80257111
7x25E3endothelin_off7.8866700021
7x317x35endothelin_off7.4233300111
1x221x23endothelin_off3.2866700122
7x237x24endothelin_off3.2507112
6x586x62endothelin_off3.1833300111
6x627x26endothelin_off3.1266707112
2x602x64endothelin_off2.7466700112
3x22E2Shared2.623331.56250021
7x42Ligendothelin_off2.14001610
5x36E2x52Shared1.576672.70112
3x21E1x50endothelin_off1.4066700021
1x221x25endothelin_off1.3700121
1x251x26endothelin_off1.3666700112
5x335x37endothelin_off0.94666702122
6x58Ligendothelin_on_gp07.48750110
5x36Ligendothelin_on_gp06.92250110
E2Ligendothelin_on_gp055.40752110
E3Ligendothelin_on_gp08.99757110
6x62Ligendothelin_on_gp04.2557110
7x23Ligendothelin_on_gp04.36757110
LigNTendothelin_on_gp04.051101
7x27Ligendothelin_on_gp09.26750110
1x25Ligendothelin_on_gp04.45750110
7x31Ligendothelin_on_gp010.3550110
7x34Ligendothelin_on_gp015.320110
E2x51Ligendothelin_on_gp05.95250110
E1Ligendothelin_on_gp04.25250010
7x35Ligendothelin_on_gp04.2054110
2x59Ligendothelin_on_gp03.67750110
E1x50Ligendothelin_on_gp03.52252110
NTNTendothelin_on_gp05.2852111
E3NTendothelin_on_gp02.8957111
7x23NTendothelin_on_gp05.927111
1x22E3endothelin_on_gp02.9050121
2x533x36endothelin_on_gp03.33751111
2x536x48endothelin_on_gp04.96251111
2x542x57endothelin_on_gp04.452501622
2x547x42endothelin_on_gp02.7101621
2x562x60endothelin_on_gp06.73250121
2x563x32endothelin_on_gp016.64250121
2x577x42endothelin_on_gp04.497511621
2x592x60endothelin_on_gp02.8350111
2x607x38endothelin_on_gp06.370111
2x647x35endothelin_on_gp018.46250021
E1x49E1x51endothelin_on_gp04.42750122
5x36E2endothelin_on_gp03.710111
5x295x32endothelin_on_gp04.54750022
5x395x40endothelin_on_gp03.45751122
5x406x55endothelin_on_gp08.040021
5x425x43endothelin_on_gp03.991121
6x486x51endothelin_on_gp05.12251111
6x556x58endothelin_on_gp08.04251111
1x24NTendothelin_on_gp04.4150111
2x567x38endothelin_on_gp03.50121
3x21E1x52endothelin_on_gp03.01250022
7x26E3endothelin_on_gp03.77750121
1x24Ligendothelin_on_gp02.820110
1x227x23endothelin_on_gp06.4850121
1x241x25endothelin_on_gp04.250111
1x267x27endothelin_on_gp02.820021
3x365x46endothelin_on_gp06.311112
5x435x46endothelin_on_gp05.861112
5x466x52endothelin_on_gp04.3551121
5x365x37endothelin_on_gp02.430112
1x281x31endothelin_on_gp02.2250022
1x322x64endothelin_on_gp02.11502422
4x645x32endothelin_on_gp01.750022
7x237x25endothelin_on_gp01.7457112

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
Id Description
endothelin_on_gp etb_on_gp
eta_on_gp
endothelin_off etb_off
Network Difference
Value endothelin_on_gp endothelin_off
Imin 2.6625 3.52667
Number of Linked Nodes 908 279
Number of Specific Nodes 630 (69.38%) 1  (0.36%)
Number of Shared Nodes 278 (30.62%) 278  (99.64%)
Number of Links 1110 317
Number of Specific Links 939 (84.59%) 146  (46.06%)
Number of Shared Links 171 (15.41%) 171  (53.94%)
Number of Hubs 177 44
Number of Specific Hubs 151 (85.31%) 18  (40.91%)
Number of Shared Hubs 26 (14.69%) 26  (59.09%)
Average % Shared Neighbours (Jaccard) 12.01
Average % Shared Neighbours (Otsuka) 15.24
Average % Shared Neighbours (Overlap Coefficient) 18.47
Average % Shared Cliques (k3-6) 51.61
Graphlets Similarity 0.671702
Paths Difference
Value endothelin_on_gp endothelin_off
Number Of Nodes in MetaPath 89 70
Specific Nodes in MetaPath 80 (89.89%) 61  (87.14%)
Shared Nodes in MetaPath 278 (30.62%) 278  (30.62%)
Number Of Links MetaPath 91 71
Specific Links in MetaPath 88 (96.70%) 68  (95.77%)
Shared Links in MetaPath 171 (15.41%) 171  (15.41%)
Number of Shortest Paths 4439274 49359
Length Of Smallest Path 3 3
Average Path Length 42.2304 12.6638
Length of Longest Path 72 33
Minimum Path Strength 0.51875 0.563333
Average Path Strength 5.37041 5.84197
Maximum Path Strength 37.1212 17.0317
Minimum Path Correlation 0.7025 0.7
Average Path Correlation 0.990082 0.93063
Maximum Path Correlation 1 0.99
Minimum % Of Corr. Nodes 1.66667 4.34783
Average % Of Corr. Nodes 31.5191 51.5106
Maximum % Of Corr. Nodes 100 100
Minimum Path Hubs % 0 0
Average Path Hubs % 51.2147 44.9522
Maximum Path Hubs % 100 100

Details about the values in these tables can be found in the corresponding documentation page .

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download endothelin_off_on_gp.zip<



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