psnGPCR

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Orange: nodes, hubs and links specific of ep4_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of ep4_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	ep4_off Int. Strength	ep4_on Int. Strength	ep4_off Hub1?	ep4_on Hub1?	ep4_off Hub2?	ep4_on Hub2?	ConSurf1	ConSurf2
1	1x33	1x34	ep4_off	100	0	No	No	No	No	4	1
2	1x38	1x39	ep4_off	100	0	No	No	Yes	No	6	7
3	1x38	Lig	ep4_off	100	0	No	No	Yes	Yes	6	0
4	1x39	2x60	ep4_off	100	0	Yes	No	No	No	7	8
5	1x39	2x61	ep4_off	100	0	Yes	No	No	No	7	6
6	1x42	7x47	ep4_off	100	0	No	No	No	No	8	8
7	1x43	2x55	ep4_off	100	0	No	No	No	No	6	5
8	1x50	2x47	ep4_off	100	0	No	No	No	No	9	8
9	1x54	2x44	ep4_off	100	0	Yes	No	No	No	8	6
10	1x59	I1.K47	ep4_off	100	0	No	No	No	No	6	6
11	2x37	I1.K47	ep4_off	100	0	No	No	No	No	7	6
12	I1.E51	I1.Q49	ep4_off	100	0	Yes	No	No	No	7	6
13	I1.K50	I2x53	ep4_off	100	0	No	No	Yes	Yes	7	8
14	6x29	I1.E51	ep4_off	100	0	No	No	Yes	No	7	7
15	6x30	I1.E51	ep4_off	100	0	No	Yes	Yes	No	8	7
16	6x33	I1.E51	ep4_off	100	0	No	No	Yes	No	9	7
17	2x38	2x41	ep4_off	100	0	No	No	No	No	6	6
18	2x38	4x38	ep4_off	100	0	No	No	Yes	No	6	8
19	2x39	3x46	ep4_off	100	0	Yes	No	No	No	8	9
20	2x39	3x50	ep4_off	100	0	Yes	No	Yes	No	8	9
21	2x39	6x33	ep4_off	100	0	Yes	No	No	No	8	9
22	2x39	6x37	ep4_off	100	0	Yes	No	No	Yes	8	8
23	2x40	6x36	ep4_off	100	0	No	No	No	No	8	8
24	2x42	4x46	ep4_off	100	0	No	No	No	No	8	8
25	2x43	7x53	ep4_off	100	0	No	No	No	Yes	8	9
26	2x45	2x48	ep4_off	100	0	No	No	No	No	8	5
27	2x50	3x39	ep4_off	100	0	No	Yes	Yes	No	9	9
28	2x52	2x551	ep4_off	100	0	No	No	No	No	7	6
29	2x54	2x57	ep4_off	100	0	No	No	No	No	8	8
30	2x54	7x46	ep4_off	100	0	No	No	No	No	8	9
31	2x551	3x27	ep4_off	100	0	No	No	No	No	6	5
32	3x30	4x61	ep4_off	100	0	No	No	No	No	7	5
33	3x32	E2x51	ep4_off	100	0	No	No	Yes	Yes	8	6
34	3x33	4x57	ep4_off	100	0	Yes	Yes	No	No	7	8
35	3x34	3x38	ep4_off	100	0	Yes	No	No	No	7	8
36	3x34	4x50	ep4_off	100	0	Yes	No	No	Yes	7	8
37	3x37	4x56	ep4_off	100	0	Yes	No	No	No	8	7
38	3x38	4x53	ep4_off	100	0	No	No	No	No	8	8
39	3x39	7x45	ep4_off	100	0	Yes	No	No	No	9	9
40	3x39	7x46	ep4_off	100	0	Yes	No	No	No	9	9
41	3x39	7x49	ep4_off	100	0	Yes	No	No	No	9	9
42	3x40	5x51	ep4_off	100	0	No	No	Yes	No	8	7
43	3x41	4x53	ep4_off	100	0	No	No	No	No	7	8
44	3x42	4x46	ep4_off	100	0	No	No	No	No	8	8
45	3x42	4x49	ep4_off	100	0	No	No	No	No	8	7
46	3x43	3x46	ep4_off	100	0	No	No	No	No	8	9
47	3x43	6x41	ep4_off	100	0	No	No	No	No	8	8
48	3x49	3x50	ep4_off	100	0	No	No	Yes	No	9	9
49	3x49	4x38	ep4_off	100	0	No	No	Yes	No	9	8
50	3x50	I2x53	ep4_off	100	0	Yes	No	Yes	Yes	9	8
51	3x50	4x38	ep4_off	100	0	Yes	No	Yes	No	9	8
52	3x51	3x52	ep4_off	100	0	Yes	Yes	No	No	8	6
53	3x55	3x56	ep4_off	100	0	No	No	No	No	7	7
54	3x56	I2x52	ep4_off	100	0	No	No	No	No	7	5
55	I2x51	I2x54	ep4_off	100	0	No	No	No	No	7	6
56	4x38	I2x53	ep4_off	100	0	Yes	No	Yes	Yes	8	8
57	4x40	I2x56	ep4_off	100	0	No	No	No	No	5	5
58	4x41	I2x56	ep4_off	100	0	No	No	No	No	5	5
59	4x38	I2x57	ep4_off	100	0	Yes	No	No	No	8	7
60	4x43	4x46	ep4_off	100	0	No	No	No	No	5	8
61	4x56	5x46	ep4_off	100	0	No	No	No	No	7	6
62	4x59	4x60	ep4_off	100	0	Yes	No	No	No	8	9
63	4x59	5x39	ep4_off	100	0	Yes	No	Yes	Yes	8	8
64	4x60	E2.G159	ep4_off	100	0	No	No	No	No	9	7
65	E2.S161	E2x50	ep4_off	100	0	Yes	No	Yes	No	5	9
66	E2.Q164	E2.R162	ep4_off	100	0	Yes	No	Yes	No	7	4
67	E2.R162	E2.W174	ep4_off	100	0	Yes	No	Yes	Yes	4	5
68	E2.L163	E2x50	ep4_off	100	0	No	No	Yes	No	4	9
69	E2.Q164	E2x51	ep4_off	100	0	Yes	No	Yes	Yes	7	6
70	7x35	E2.W169	ep4_off	100	0	Yes	Yes	Yes	Yes	6	5
71	6x51	E2x51	ep4_off	100	0	No	No	Yes	Yes	7	6
72	5x40	E2x52	ep4_off	100	0	No	No	Yes	No	7	7
73	6x55	E2.W174	ep4_off	100	0	No	No	Yes	Yes	7	5
74	5x33	E2.T176	ep4_off	100	0	No	No	No	No	3	4
75	5x39	5x42	ep4_off	100	0	Yes	Yes	No	No	8	5
76	5x51	6x45	ep4_off	100	0	Yes	No	No	No	7	6
77	5x54	6x41	ep4_off	100	0	No	No	No	No	8	8
78	5x54	6x45	ep4_off	100	0	No	No	No	No	8	6
79	5x58	6x38	ep4_off	100	0	No	Yes	Yes	No	9	7
80	5x61	6x34	ep4_off	100	0	No	No	No	No	9	7
81	6x29	6x32	ep4_off	100	0	No	No	No	No	7	8
82	6x31	8x55	ep4_off	100	0	No	No	No	No	6	4
83	6x32	8x48	ep4_off	100	0	No	No	No	No	8	6
84	6x35	8x51	ep4_off	100	0	No	No	No	No	7	7
85	6x36	7x53	ep4_off	100	0	No	No	No	Yes	8	9
86	6x36	7x56	ep4_off	100	0	No	No	No	No	8	8
87	6x37	6x41	ep4_off	100	0	No	Yes	No	No	8	8
88	6x40	7x52	ep4_off	100	0	No	No	No	No	8	8
89	6x47	7x40	ep4_off	100	0	No	No	No	No	9	8
90	6x51	7x37	ep4_off	100	0	No	No	No	No	7	7
91	E3.E303	E3.K308	ep4_off	100	0	No	No	No	No	3	4
92	E3.E305	E3.S307	ep4_off	100	0	No	No	No	No	1	4
93	7x33	7x34	ep4_off	100	0	No	No	Yes	Yes	4	6
94	7x43	Lig	ep4_off	100	0	No	No	Yes	Yes	5	0
95	7x56	8x51	ep4_off	100	0	No	No	No	No	8	7
96	8x51	8x55	ep4_off	100	0	No	No	No	No	7	4
97	1x36	2x65	ep4_off	50	0	No	No	No	No	6	4
98	2x43	3x46	ep4_off	50	0	No	No	No	No	8	9
99	3x29	E2x52	ep4_off	50	0	No	No	Yes	No	7	7
100	1x56	1x57	ep4_off	50	0	No	No	No	No	7	8
101	2x43	2x47	ep4_off	50	0	No	No	No	No	8	8
102	8x58	8x59	ep4_off	0	0	No	No	No	No	5	4
103	6x32	8x52	ep4_off	0	0	No	No	No	No	8	5
104	1x51	1x54	ep4_off	0	0	No	No	Yes	No	5	8
105	3x54	5x65	ep4_off	0	0	No	No	No	Yes	9	9
106	6x38	6x42	ep4_off	0	0	Yes	No	No	No	7	6
107	1x35	2x64	ep4_off	0	0	No	No	No	No	5	6
108	7x50	7x51	ep4_off	0	0	No	No	No	No	9	7
109	5x48	6x56	ep4_off	0	0	No	No	No	No	6	6
110	5x68	5x69	ep4_off	0	0	No	No	No	No	7	5
111	3x22	3x26	ep4_off	0	0	No	No	No	No	2	6
112	3x36	5x43	ep4_off	0	0	No	No	No	No	7	7
113	E2.Y165	E3.V306	ep4_off	0	0	Yes	Yes	No	No	3	3
114	3x28	E1x50	ep4_off	0	0	No	No	Yes	Yes	6	6
115	5x62	5x63	ep4_off	0	0	No	No	No	No	7	3
116	1x42	Lig	ep4_off	0	0	No	No	Yes	Yes	8	0
117	2x62	E1x51	ep4_off	0	0	No	No	Yes	No	6	4
118	5x45	5x48	ep4_off	0	0	No	No	No	No	5	6
119	2x63	E1x51	ep4_off	0	0	No	No	Yes	No	7	4
120	4x59	4x63	ep4_off	0	0	Yes	No	No	No	8	8
121	5x62	6x38	ep4_off	0	0	No	No	Yes	No	7	7
122	1x40	2x61	ep4_off	0	0	No	No	No	No	5	6
123	3x54	5x64	ep4_off	0	0	No	No	No	No	9	7
124	1x37	1x41	ep4_off	0	0	No	No	No	No	5	5
125	1x52	7x54	ep4_off	0	0	No	No	No	Yes	6	8
126	5x51	5x55	ep4_off	0	0	Yes	No	No	No	7	6
127	4x41	I2x57	ep4_off	0	0	No	No	No	No	5	7
128	4x54	4x55	ep4_off	0	0	No	No	No	No	4	4
129	E3.E305	E3.V306	ep4_off	0	0	No	No	No	No	1	3
130	7x54	8x47	ep4_off	0	0	No	Yes	No	No	8	9
131	8x52	8x56	ep4_off	0	0	No	No	No	No	5	4
132	1x36	2x64	Shared	100	100	No	No	No	No	6	6
133	1x39	Lig	Shared	100	100	Yes	No	Yes	Yes	7	0
134	1x41	1x45	Shared	100	100	No	No	No	No	5	5
135	1x43	1x47	Shared	100	100	No	No	No	No	6	7
136	1x43	2x57	Shared	100	100	No	No	No	No	6	8
137	1x45	7x47	Shared	100	25	No	No	No	No	5	8
138	1x48	1x49	Shared	100	50	No	No	No	No	5	9
139	1x50	2x51	Shared	100	100	No	No	No	Yes	9	8
140	1x50	7x50	Shared	100	100	No	No	No	No	9	9
141	1x51	2x51	Shared	100	0	No	No	No	Yes	5	8
142	1x53	7x54	Shared	100	50	No	No	No	Yes	9	8
143	1x54	2x48	Shared	100	0	Yes	No	No	No	8	5
144	1x57	2x40	Shared	100	100	No	No	No	No	8	8
145	2x42	3x49	Shared	100	25	No	No	No	No	8	9
146	2x46	3x42	Shared	100	100	No	No	No	No	9	8
147	2x49	4x50	Shared	100	100	No	No	No	Yes	9	8
148	2x50	7x49	Shared	100	100	No	Yes	No	No	9	9
149	2x52	3x35	Shared	100	25	No	No	Yes	Yes	7	7
150	2x53	3x35	Shared	100	100	No	No	Yes	Yes	8	7
151	2x551	3x31	Shared	100	100	No	No	No	Yes	6	5
152	2x57	2x58	Shared	100	100	No	No	No	No	8	9
153	2x59	3x28	Shared	100	25	No	No	No	No	7	6
154	2x60	Lig	Shared	100	100	No	No	Yes	Yes	8	0
155	2x64	Lig	Shared	100	100	No	No	Yes	Yes	6	0
156	E1x50	E1x51	Shared	100	25	Yes	Yes	Yes	No	6	4
157	3x24	E1x50	Shared	100	100	No	No	Yes	Yes	6	6
158	E1x50	E2.L163	Shared	100	100	Yes	Yes	No	No	6	4
159	E1x50	E2x50	Shared	100	50	Yes	Yes	Yes	No	6	9
160	3x24	E1x52	Shared	100	100	No	No	No	No	6	5
161	3x22	3x23	Shared	100	100	No	No	No	No	2	2
162	3x25	E2.S161	Shared	100	50	No	No	Yes	No	9	5
163	3x25	E2x50	Shared	100	100	No	No	Yes	No	9	9
164	3x26	E2.S161	Shared	100	100	No	No	Yes	No	6	5
165	3x27	3x31	Shared	100	100	No	No	No	Yes	5	5
166	3x29	E2.S161	Shared	100	100	No	No	Yes	No	7	5
167	3x31	3x35	Shared	100	100	No	Yes	Yes	Yes	5	7
168	3x32	Lig	Shared	100	100	No	No	Yes	Yes	8	0
169	3x33	E2x51	Shared	100	100	Yes	Yes	Yes	Yes	7	6
170	3x33	E2x52	Shared	100	100	Yes	Yes	Yes	No	7	7
171	3x33	5x43	Shared	100	100	Yes	Yes	No	No	7	7
172	3x34	3x35	Shared	100	100	Yes	No	Yes	Yes	7	7
173	3x34	4x54	Shared	100	100	Yes	No	No	No	7	4
174	3x37	4x53	Shared	100	100	Yes	No	No	No	8	8
175	3x37	5x43	Shared	100	25	Yes	No	No	No	8	7
176	3x37	5x46	Shared	100	25	Yes	No	No	No	8	6
177	3x40	5x50	Shared	100	25	No	No	No	Yes	8	8
178	3x40	6x48	Shared	100	100	No	No	No	No	8	8
179	3x43	6x44	Shared	100	50	No	No	No	No	8	8
180	3x44	5x50	Shared	100	100	No	No	No	Yes	7	8
181	3x47	5x54	Shared	100	100	No	No	No	No	9	8
182	3x47	5x57	Shared	100	100	No	No	No	No	9	7
183	3x48	5x57	Shared	100	25	No	No	No	No	7	7
184	3x50	6x33	Shared	100	25	Yes	No	No	No	9	9
185	3x51	3x55	Shared	100	100	Yes	Yes	No	No	8	7
186	3x51	5x60	Shared	100	100	Yes	Yes	No	No	8	5
187	3x54	5x61	Shared	100	100	No	No	No	No	9	9
188	I2x53	I2x57	Shared	100	100	Yes	Yes	No	No	8	7
189	I2x55	I2x56	Shared	100	100	No	No	No	No	5	5
190	4x56	5x42	Shared	100	25	No	No	No	No	7	5
191	4x59	E2.L158	Shared	100	100	Yes	No	No	No	8	5
192	4x60	5x39	Shared	100	100	No	No	Yes	Yes	9	8
193	5x39	E2.L158	Shared	100	50	Yes	Yes	No	No	8	5
194	5x36	E2.G159	Shared	100	100	Yes	Yes	No	No	5	7
195	5x36	E2.S160	Shared	100	100	Yes	Yes	No	No	5	3
196	E2.D173	E2.R162	Shared	100	100	No	Yes	Yes	No	5	4
197	E2.R162	E2.T175	Shared	100	100	Yes	No	No	Yes	4	4
198	E2.D167	E2.L163	Shared	100	100	No	No	No	No	5	4
199	E2.Q164	E2.W169	Shared	100	100	Yes	No	Yes	Yes	7	5
200	E2.Q164	E2.W174	Shared	100	100	Yes	No	Yes	Yes	7	5
201	E2.P166	E2.Y165	Shared	100	100	No	Yes	Yes	Yes	6	3
202	E2.Y165	E3.L302	Shared	100	100	Yes	Yes	No	No	3	1
203	E2.P166	E2.T168	Shared	100	100	No	Yes	No	Yes	6	6
204	E2.T168	E2.W169	Shared	100	100	No	Yes	Yes	Yes	6	5
205	E2.W169	E2x51	Shared	100	100	Yes	Yes	Yes	Yes	5	6
206	7x38	E2.W169	Shared	100	100	No	No	Yes	Yes	6	5
207	E2.W169	Lig	Shared	100	100	Yes	Yes	Yes	Yes	5	0
208	E2x51	E2x52	Shared	100	100	Yes	Yes	Yes	No	6	7
209	E2.W174	E2x51	Shared	100	100	Yes	Yes	Yes	Yes	5	6
210	E2.D173	E2.T175	Shared	100	100	No	Yes	No	Yes	5	4
211	E2.D173	E2.T176	Shared	100	100	No	Yes	No	No	5	4
212	6x58	E2.W174	Shared	100	100	Yes	Yes	Yes	Yes	6	5
213	7x34	E2.W174	Shared	100	100	Yes	Yes	Yes	Yes	6	5
214	5x36	E2.T176	Shared	100	100	Yes	Yes	No	No	5	4
215	5x33	5x36	Shared	100	100	No	No	Yes	Yes	3	5
216	5x37	6x59	Shared	100	100	No	No	No	No	5	6
217	5x40	6x59	Shared	100	100	No	No	No	No	7	6
218	5x41	6x59	Shared	100	100	No	No	No	No	5	6
219	5x41	6x60	Shared	100	25	No	No	No	No	5	4
220	5x44	6x55	Shared	100	0	No	No	No	No	7	7
221	5x44	6x56	Shared	100	100	No	No	No	No	7	6
222	5x46	5x50	Shared	100	100	No	No	No	Yes	6	8
223	5x47	6x52	Shared	100	100	No	No	No	No	7	7
224	5x51	6x49	Shared	100	0	Yes	No	No	No	7	7
225	5x56	5x60	Shared	100	25	No	No	No	No	4	5
226	5x58	6x37	Shared	100	100	No	Yes	No	Yes	9	8
227	6x34	6x38	Shared	100	0	No	No	Yes	No	7	7
228	6x40	7x53	Shared	100	100	No	No	No	Yes	8	9
229	6x43	7x52	Shared	100	50	No	No	No	No	6	8
230	6x47	7x45	Shared	100	100	No	No	No	No	9	9
231	6x49	6x50	Shared	100	75	No	No	No	No	7	9
232	6x50	7x40	Shared	100	50	No	No	No	No	9	8
233	6x54	6x57	Shared	100	100	Yes	Yes	No	No	6	5
234	6x54	6x58	Shared	100	100	Yes	Yes	Yes	Yes	6	6
235	6x54	7x33	Shared	100	100	Yes	Yes	No	No	6	4
236	6x54	7x34	Shared	100	100	Yes	Yes	Yes	Yes	6	6
237	6x58	E3.P300	Shared	100	100	Yes	Yes	No	No	6	1
238	6x58	7x34	Shared	100	100	Yes	Yes	Yes	Yes	6	6
239	6x60	6x61	Shared	100	100	No	No	No	No	4	4
240	E3.K308	E3.S307	Shared	100	100	No	No	No	No	4	4
241	7x32	7x33	Shared	100	100	No	No	No	No	2	4
242	7x32	7x35	Shared	100	100	No	No	Yes	Yes	2	6
243	7x35	7x39	Shared	100	100	Yes	Yes	No	Yes	6	7
244	7x35	Lig	Shared	100	100	Yes	Yes	Yes	Yes	6	0
245	7x38	Lig	Shared	100	100	No	No	Yes	Yes	6	0
246	7x39	Lig	Shared	100	100	No	Yes	Yes	Yes	7	0
247	7x42	Lig	Shared	100	100	No	No	Yes	Yes	8	0
248	7x45	7x49	Shared	100	100	No	No	No	No	9	9
249	8x47	8x50	Shared	100	25	No	No	No	No	9	7
250	8x49	8x53	Shared	100	25	No	No	No	No	7	7
251	5x48	5x52	Shared	50	25	No	No	No	No	6	4
252	2x56	3x32	Shared	50	100	No	No	No	No	7	8
253	6x43	7x48	Shared	50	25	No	No	No	No	6	7
254	1x54	2x47	Shared	0	0	Yes	No	No	No	8	8
255	3x30	4x57	Shared	0	100	No	No	No	No	7	8
256	3x51	5x57	Shared	0	100	Yes	Yes	No	No	8	7
257	1x34	1x35	Shared	50	100	No	No	No	No	1	5
258	3x53	I2x53	Shared	0	100	No	No	Yes	Yes	9	8
259	6x52	6x56	Shared	0	0	No	No	No	No	7	6
260	I2x51	I2x55	Shared	0	0	No	No	No	No	7	5
261	3x21	E1x52	Shared	0	0	No	No	No	No	5	5
262	3x30	4x58	Shared	0	0	No	No	No	No	7	6
263	4x42	4x43	Shared	0	0	No	No	No	No	8	5
264	1x53	7x50	Shared	0	25	No	No	No	No	9	9
265	3x44	5x53	Shared	0	0	No	No	No	No	7	6
266	1x46	7x47	Shared	0	50	No	No	No	No	8	8
267	5x33	5x35	Shared	0	0	No	No	No	No	3	3
268	3x45	4x45	Shared	0	0	No	No	No	No	8	7
269	2x66	E1x51	Shared	0	100	No	No	Yes	No	5	4
270	6x46	6x47	Shared	0	0	No	No	No	No	7	9
271	1x58	1x59	Shared	0	25	No	No	No	No	4	6
272	6x39	7x52	Shared	0	25	No	No	No	No	6	8
273	5x55	5x59	Shared	0	0	No	No	No	No	6	4
274	6x53	6x57	Shared	0	25	No	No	No	No	7	5
275	4x45	4x49	Shared	0	0	No	No	No	No	7	7
276	E3.P300	E3.Q299	Shared	0	100	No	No	No	No	1	2
277	1x44	1x48	Shared	0	0	No	No	No	No	5	5
278	1x49	7x51	Shared	0	0	No	No	No	No	9	7
279	E2.Y165	E3.R304	Shared	0	100	Yes	Yes	No	No	3	1
280	1x38	7x39	ep4_on	0	100	No	No	No	Yes	6	7
281	1x42	7x39	ep4_on	0	100	No	No	No	Yes	8	7
282	1x50	2x50	ep4_on	0	100	No	No	No	Yes	9	9
283	1x55	1x59	ep4_on	0	100	No	No	No	No	5	6
284	1x57	2x44	ep4_on	0	100	No	No	No	No	8	6
285	I1.K47	I1.K50	ep4_on	0	100	No	No	No	No	6	7
286	2x40	I1.K50	ep4_on	0	100	No	No	No	No	8	7
287	2x38	3x49	ep4_on	0	100	No	No	No	No	6	9
288	2x38	I2x53	ep4_on	0	100	No	No	Yes	Yes	6	8
289	2x39	2x43	ep4_on	0	100	Yes	No	No	No	8	8
290	2x40	2x44	ep4_on	0	100	No	No	No	No	8	6
291	2x41	4x42	ep4_on	0	100	No	No	No	No	6	8
292	2x42	3x46	ep4_on	0	100	No	No	No	No	8	9
293	2x46	7x49	ep4_on	0	100	No	No	No	No	9	9
294	2x49	3x38	ep4_on	0	100	No	No	No	No	9	8
295	2x50	7x46	ep4_on	0	100	No	Yes	No	No	9	9
296	2x54	Lig	ep4_on	0	100	No	No	Yes	Yes	8	0
297	2x56	3x31	ep4_on	0	100	No	No	No	Yes	7	5
298	2x56	Lig	ep4_on	0	100	No	No	Yes	Yes	7	0
299	2x57	Lig	ep4_on	0	100	No	No	Yes	Yes	8	0
300	2x63	E1x50	ep4_on	0	100	No	No	Yes	Yes	7	6
301	2x63	E2.T168	ep4_on	0	100	No	No	No	Yes	7	6
302	2x64	E2.T168	ep4_on	0	100	No	No	No	Yes	6	6
303	3x26	4x61	ep4_on	0	100	No	No	No	No	6	5
304	3x33	5x39	ep4_on	0	100	Yes	Yes	Yes	Yes	7	8
305	3x34	4x57	ep4_on	0	100	Yes	No	No	No	7	8
306	3x36	Lig	ep4_on	0	100	No	No	Yes	Yes	7	0
307	3x38	4x50	ep4_on	0	100	No	No	No	Yes	8	8
308	3x41	4x49	ep4_on	0	100	No	No	No	No	7	7
309	3x41	5x50	ep4_on	0	100	No	No	No	Yes	7	8
310	3x42	4x50	ep4_on	0	100	No	No	No	Yes	8	8
311	3x43	5x54	ep4_on	0	100	No	No	No	No	8	8
312	3x44	5x54	ep4_on	0	100	No	No	No	No	7	8
313	3x46	7x53	ep4_on	0	100	No	No	No	Yes	9	9
314	3x47	5x58	ep4_on	0	100	No	No	No	Yes	9	9
315	3x49	I2x53	ep4_on	0	100	No	No	Yes	Yes	9	8
316	3x50	5x58	ep4_on	0	100	Yes	No	No	Yes	9	9
317	3x50	6x37	ep4_on	0	100	Yes	No	No	Yes	9	8
318	3x51	3x56	ep4_on	0	100	Yes	Yes	No	No	8	7
319	3x52	3x56	ep4_on	0	100	No	No	No	No	6	7
320	3x55	5x64	ep4_on	0	100	No	No	No	No	7	7
321	I2x52	I2x56	ep4_on	0	100	No	No	No	No	5	5
322	I2x54	I2x55	ep4_on	0	100	No	No	No	No	6	5
323	4x38	4x40	ep4_on	0	100	Yes	No	No	No	8	5
324	4x46	4x50	ep4_on	0	100	No	No	No	Yes	8	8
325	4x56	5x39	ep4_on	0	100	No	No	Yes	Yes	7	8
326	E2.D173	E2.S160	ep4_on	0	100	No	Yes	No	No	5	3
327	7x34	E2.Q164	ep4_on	0	100	Yes	Yes	Yes	No	6	7
328	E2.P166	E2.W169	ep4_on	0	100	No	Yes	Yes	Yes	6	5
329	E2.T168	Lig	ep4_on	0	100	No	Yes	Yes	Yes	6	0
330	5x39	E2x52	ep4_on	0	100	Yes	Yes	Yes	No	8	7
331	E2.T175	E2.W174	ep4_on	0	100	No	Yes	Yes	Yes	4	5
332	5x51	6x48	ep4_on	0	100	Yes	No	No	No	7	8
333	5x55	6x41	ep4_on	0	100	No	No	No	No	6	8
334	5x55	6x45	ep4_on	0	100	No	No	No	No	6	6
335	5x58	6x41	ep4_on	0	100	No	Yes	No	No	9	8
336	5x62	6x37	ep4_on	0	100	No	No	No	Yes	7	8
337	5x65	6x30	ep4_on	0	100	No	Yes	No	Yes	9	8
338	5x65	6x34	ep4_on	0	100	No	Yes	No	No	9	7
339	6x42	6x46	ep4_on	0	100	No	No	No	No	6	7
340	6x51	7x41	ep4_on	0	100	No	No	No	No	7	8
341	6x54	7x37	ep4_on	0	100	Yes	Yes	No	No	6	7
342	E3.E303	E3.E305	ep4_on	0	100	No	No	No	No	3	1
343	7x32	E3.E303	ep4_on	0	100	No	No	No	No	2	3
344	7x33	E3.E303	ep4_on	0	100	No	No	No	No	4	3
345	7x45	7x46	ep4_on	0	100	No	No	No	No	9	9
346	7x46	Lig	ep4_on	0	100	No	No	Yes	Yes	9	0
347	7x51	7x55	ep4_on	0	100	No	No	No	No	7	6
348	7x52	7x53	ep4_on	0	100	No	No	No	Yes	8	9
349	8x53	8x56	ep4_on	0	100	No	No	No	No	7	4
350	8x53	8x57	ep4_on	0	100	No	No	No	No	7	4
351	1x57	7x54	ep4_on	0	100	No	No	No	Yes	8	8
352	1x60	I1.K50	ep4_on	0	100	No	No	No	No	6	7
353	2x43	7x54	ep4_on	0	100	No	No	No	Yes	8	8
354	2x46	2x50	ep4_on	0	100	No	No	No	Yes	9	9
355	3x43	7x53	ep4_on	0	100	No	No	No	Yes	8	9
356	4x38	4x39	ep4_on	0	100	Yes	No	No	No	8	5
357	7x34	E2.Y165	ep4_on	0	100	Yes	Yes	Yes	Yes	6	3
358	7x35	E2.P166	ep4_on	0	100	Yes	Yes	No	Yes	6	6
359	E2.T175	E3.Q299	ep4_on	0	100	No	Yes	No	No	4	2
360	5x69	5x73	ep4_on	0	100	No	No	No	No	5	0
361	5x69	6x30	ep4_on	0	100	No	No	No	Yes	5	8
362	5x69	6x31	ep4_on	0	100	No	No	No	No	5	6
363	5x70	5x74	ep4_on	0	100	No	No	No	No	0	0
364	6x47	7x43	ep4_on	0	100	No	No	No	No	9	5
365	7x43	7x47	ep4_on	0	100	No	No	No	No	5	8
366	3x35	Lig	ep4_on	0	100	Yes	Yes	Yes	Yes	7	0
367	5x72	5x76	ep4_on	0	100	No	Yes	No	No	0	0
368	5x61	6x37	ep4_on	0	75	No	No	No	Yes	9	8
369	5x72	5x75	ep4_on	0	50	No	Yes	No	No	0	0
370	2x38	4x42	ep4_on	0	50	No	No	No	No	6	8
371	7x54	7x55	ep4_on	0	50	No	Yes	No	No	8	6
372	1x56	8x50	ep4_on	0	50	No	No	No	No	7	7
373	2x51	2x55	ep4_on	0	25	No	Yes	No	No	8	5
374	2x59	E1x50	ep4_on	0	25	No	No	Yes	Yes	7	6
375	3x52	I2x52	ep4_on	0	25	No	No	No	No	6	5
376	3x40	5x47	ep4_on	0	50	No	No	No	No	8	7
377	1x60	I1.Q49	ep4_on	0	50	No	No	No	No	6	6
378	2x65	2x66	ep4_on	0	25	No	No	No	No	4	5
379	1x43	2x61	ep4_on	0	50	No	No	No	No	6	6
380	5x72	5x73	ep4_on	0	50	No	Yes	No	No	0	0
381	5x64	5x67	ep4_on	0	50	No	No	No	No	7	4
382	4x38	4x41	ep4_on	0	50	Yes	No	No	No	8	5
383	7x36	E3.K308	ep4_on	0	25	No	No	No	No	3	4
384	E3.E305	E3.K308	ep4_on	0	25	No	No	No	No	1	4
385	5x71	5x74	ep4_on	0	25	No	No	No	No	0	0
386	1x52	7x55	ep4_on	0	25	No	No	No	No	6	6
387	1x35	1x37	ep4_on	0	25	No	No	No	No	5	5
388	5x72	6x24	ep4_on	0	25	No	Yes	No	No	0	0
389	2x39	8x47	ep4_on	0	25	Yes	No	No	No	8	9
390	5x43	6x51	ep4_on	0	25	No	No	No	No	7	7
391	I1.Q49	I1.R46	ep4_on	0	25	No	No	No	No	6	5
392	7x51	7x56	ep4_on	0	25	No	No	No	No	7	8
393	1x56	8x49	ep4_on	0	25	No	No	No	No	7	7
394	7x43	7x48	ep4_on	0	50	No	No	No	No	5	7
395	3x38	3x39	ep4_on	0	50	No	No	Yes	No	8	9
396	6x36	6x40	ep4_on	0	0	No	No	No	No	8	8
397	5x41	6x56	ep4_on	0	50	No	No	No	No	5	6
398	5x65	6x33	ep4_on	0	0	No	Yes	No	No	9	9
399	5x67	5x71	ep4_on	0	25	No	No	No	No	4	0
400	I1.E48	I1.R46	ep4_on	0	25	No	No	No	No	7	5
401	2x45	4x46	ep4_on	0	0	No	No	No	No	8	8
402	E1x49	E2.D167	ep4_on	0	25	No	No	No	No	4	5
403	2x62	2x66	ep4_on	0	50	No	No	No	No	6	5
404	1x37	1x38	ep4_on	0	25	No	No	No	No	5	6
405	6x35	6x38	ep4_on	0	25	No	No	Yes	No	7	7
406	5x44	5x45	ep4_on	0	0	No	No	No	No	7	5
407	3x22	E2.R162	ep4_on	0	25	No	No	Yes	No	2	4
408	4x39	I1.E51	ep4_on	0	0	No	No	Yes	No	5	7
409	2x37	2x39	ep4_on	0	0	No	No	Yes	No	7	8
410	5x63	5x66	ep4_on	0	25	No	No	No	No	3	6
411	5x49	5x50	ep4_on	0	0	No	No	No	Yes	4	8
412	5x48	6x52	ep4_on	0	0	No	No	No	No	6	7
413	4x40	4x44	ep4_on	0	25	No	No	No	No	5	4
414	E3.S307	E3.V306	ep4_on	0	25	No	No	No	No	4	3
415	4x52	4x53	ep4_on	0	0	No	No	No	No	5	8
416	1x54	2x51	ep4_on	0	0	Yes	No	No	Yes	8	8
417	5x65	5x68	ep4_on	0	0	No	Yes	No	No	9	7
418	2x37	I1.E51	ep4_on	0	25	No	No	Yes	No	7	7
419	6x28	6x31	ep4_on	0	25	No	No	No	No	5	6
420	4x63	E2.L158	ep4_on	0	0	No	No	No	No	8	5
421	E1.G83	E1x49	ep4_on	0	0	No	No	No	No	4	4
422	8x49	8x52	ep4_on	0	0	No	No	No	No	7	5
423	6x29	6x30	ep4_on	0	0	No	No	No	Yes	7	8
424	1x51	1x55	ep4_on	0	0	No	No	No	No	5	5
425	5x66	6x34	ep4_on	0	0	No	No	No	No	6	7
426	8x55	8x59	ep4_on	0	0	No	No	No	No	4	4
427	4x59	4x62	ep4_on	0	0	Yes	No	No	No	8	5
428	8x56	8x59	ep4_on	0	0	No	No	No	No	4	4
429	I2x50	I2x51	ep4_on	0	0	No	No	No	No	9	7
430	6x32	7x56	ep4_on	0	0	No	No	No	No	8	8
431	4x46	4x47	ep4_on	0	0	No	No	No	No	8	4
432	1x36	1x40	ep4_on	0	0	No	No	No	No	6	5
433	6x27	6x30	ep4_on	0	0	No	No	No	Yes	6	8
434	E2.Q177	E2.T175	ep4_on	0	0	No	No	No	Yes	4	4
435	8x48	8x51	ep4_on	0	0	No	No	No	No	6	7
436	4x55	4x59	ep4_on	0	0	No	No	Yes	No	4	8

Orange: nodes, hubs and links specific of ep4_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of ep4_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	ep4_off Avg Int. Strength	ep4_on Avg Int. Strength	ep4_off Num Of Links	ep4_on Num Of Links	ConSurf
1	1x39	ep4_off	100	0	4	1	7
2	1x54	ep4_off	0	0	4	3	8
3	I1.E51	ep4_off	100	0	4	2	7
4	2x39	ep4_off	100	0	4	3	8
5	E1x51	ep4_off	0	0	4	2	4
6	3x34	ep4_off	100	0	4	3	7
7	3x37	ep4_off	50	0	4	3	8
8	3x39	ep4_off	100	0	4	1	9
9	3x50	ep4_off	100	25	5	3	9
10	4x38	ep4_off	100	0	5	3	8
11	4x59	ep4_off	0	0	4	3	8
12	E2.S161	ep4_off	100	25	4	3	5
13	E2.R162	ep4_off	100	0	4	3	4
14	E2.Q164	ep4_off	100	25	4	3	7
15	E2x50	ep4_off	100	0	4	2	9
16	E2x52	ep4_off	50	0	4	3	7
17	5x51	ep4_off	0	0	4	2	7
18	6x38	ep4_off	0	0	4	2	7
19	E1x50	Shared	100	100	5	6	6
20	3x33	Shared	100	50	4	4	7
21	3x35	Shared	100	50	4	5	7
22	3x51	Shared	0	50	4	4	8
23	I2x53	Shared	100	50	5	4	8
24	E2.Y165	Shared	0	75	4	4	3
25	E2.W169	Shared	100	75	6	6	5
26	E2x51	Shared	100	75	7	4	6
27	E2.W174	Shared	100	100	6	5	5
28	5x36	Shared	100	50	4	4	5
29	5x39	Shared	100	75	4	5	8
30	6x54	Shared	100	50	4	5	6
31	6x58	Shared	100	100	4	4	6
32	7x34	Shared	100	75	4	5	6
33	7x35	Shared	100	50	4	4	6
34	Lig	Shared	100	100	12	16	0
35	2x50	ep4_on	0	25	2	4	9
36	2x51	ep4_on	0	0	2	4	8
37	3x31	ep4_on	0	50	3	4	5
38	4x50	ep4_on	0	50	2	4	8
39	E2.P166	ep4_on	0	25	2	4	6
40	E2.T168	ep4_on	0	100	2	5	6
41	E2.D173	ep4_on	0	50	3	4	5
42	E2.T175	ep4_on	0	25	2	5	4
43	5x50	ep4_on	50	0	3	5	8
44	5x58	ep4_on	0	50	2	4	9
45	5x65	ep4_on	0	0	1	4	9
46	5x72	ep4_on	0	0	0	4	0
47	6x30	ep4_on	0	0	1	4	8
48	6x37	ep4_on	0	75	3	4	8
49	7x39	ep4_on	0	75	2	4	7
50	7x53	ep4_on	0	75	3	4	9
51	7x54	ep4_on	0	0	3	4	8

Orange: nodes, hubs and links specific of ep4_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of ep4_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	ep4_off Recurrence	ep4_on Recurrence	ep4_off Hub1?	ep4_on Hub1?	ep4_off Hub2?	ep4_on Hub2?	ConSurf1	ConSurf2
1	2x64	Lig	ep4_off	14.2233	5.00468	No	No	Yes	Yes	6	0
2	1x42	Lig	ep4_off	14.2233	0	No	No	Yes	Yes	8	0
3	1x42	7x47	ep4_off	12.1238	0	No	No	No	No	8	8
4	3x32	Lig	ep4_off	21.7428	1.87091	No	No	Yes	Yes	8	0
5	3x32	E2x51	ep4_off	23.7897	0	No	No	Yes	Yes	8	6
6	3x40	5x51	ep4_off	99.2107	0	No	No	Yes	No	8	7
7	5x51	6x49	ep4_off	23.4319	5.51918	Yes	No	No	No	7	7
8	6x49	6x50	ep4_off	22.1374	3.6892	No	No	No	No	7	9
9	6x50	7x40	ep4_off	20.8325	1.84752	No	No	No	No	9	8
10	6x47	7x40	ep4_off	19.5169	0	No	No	No	No	9	8
11	3x39	7x45	ep4_off	12.6868	0	Yes	No	No	No	9	9
12	5x51	6x45	ep4_off	93.4224	0	Yes	No	No	No	7	6
13	5x54	6x45	ep4_off	93.0225	0	No	No	No	No	8	6
14	5x54	6x41	ep4_off	87.9289	0	No	No	No	No	8	8
15	3x43	6x41	ep4_off	36.5765	0	No	No	No	No	8	8
16	3x43	3x46	ep4_off	35.261	0	No	No	No	No	8	9
17	2x43	3x46	ep4_off	43.1172	0	No	No	No	No	8	9
18	2x43	2x47	ep4_off	24.7158	0	No	No	No	No	8	8
19	1x50	2x47	ep4_off	16.7702	0	No	No	No	No	9	8
20	2x43	7x53	ep4_off	20.2326	0	No	No	No	Yes	8	9
21	6x36	7x53	ep4_off	12.3553	0	No	No	No	Yes	8	9
22	6x37	6x41	ep4_off	51.0524	0	No	Yes	No	No	8	8
23	2x39	6x37	ep4_off	44.2223	0	Yes	No	No	Yes	8	8
24	2x39	6x33	ep4_off	10.8188	0	Yes	No	No	No	8	9
25	6x33	I1.E51	ep4_off	10.9766	0	No	No	Yes	No	9	7
26	2x39	3x50	ep4_off	38.2919	0	Yes	No	Yes	No	8	9
27	3x50	I2x53	ep4_off	13.0288	0	Yes	No	Yes	Yes	9	8
28	3x50	4x38	ep4_off	12.8815	0	Yes	No	Yes	No	9	8
29	3x49	3x50	ep4_off	13.0394	0	No	No	Yes	No	9	9
30	2x42	4x46	ep4_off	11.0345	0	No	No	No	No	8	8
31	3x37	4x53	ep4_off	20.8061	3.6892	Yes	No	No	No	8	8
32	3x38	4x53	ep4_off	18.1435	0	No	No	No	No	8	8
33	3x34	3x38	ep4_off	16.7965	0	Yes	No	No	No	7	8
34	3x29	E2x52	ep4_off	26.3102	0	No	No	Yes	No	7	7
35	3x29	E2.S161	ep4_off	25.2	1.95276	No	No	Yes	No	7	5
36	E2.S161	E2x50	ep4_off	18.4435	0	Yes	No	Yes	No	5	9
37	5x58	6x37	ep4_off	14.0812	7.84612	No	Yes	No	Yes	9	8
38	5x58	6x38	ep4_off	12.7657	0	No	Yes	Yes	No	9	7
39	4x41	I2x57	ep4_off	16.2545	0	No	No	No	No	5	7
40	4x41	I2x56	ep4_off	13.5708	0	No	No	No	No	5	5
41	4x56	5x42	ep4_off	12.2553	3.04022	No	No	No	No	7	5
42	5x39	5x42	ep4_off	10.9451	0	Yes	Yes	No	No	8	5
43	E2.P166	E2.T168	ep4_off	12.8762	5.44902	No	Yes	No	Yes	6	6
44	6x55	E2.W174	ep4_off	12.8762	0	No	No	Yes	Yes	7	5
45	5x44	6x55	ep4_off	11.3029	1.84752	No	No	No	No	7	7
46	3x33	E2x52	ep4_off	21.3744	0.508653	Yes	Yes	Yes	No	7	7
47	3x33	E2x51	Shared	72.1743	92.7385	Yes	Yes	Yes	Yes	7	6
48	3x33	5x43	Shared	94.3643	87.4474	Yes	Yes	No	No	7	7
49	3x37	5x43	Shared	94.7537	85.6759	Yes	No	No	No	8	7
50	3x37	5x46	Shared	91.4334	83.6003	Yes	No	No	No	8	6
51	5x46	5x50	Shared	100	82.9397	No	No	No	Yes	6	8
52	3x40	5x50	Shared	99.558	34.8398	No	No	No	Yes	8	8
53	6x47	7x45	Shared	16.8543	67.9373	No	No	No	No	9	9
54	E2.W169	Lig	Shared	25.3526	83.2086	Yes	Yes	Yes	Yes	5	0
55	E2.W169	E2x51	Shared	37.0817	89.9965	Yes	Yes	Yes	Yes	5	6
56	1x50	7x50	Shared	14.1497	81.4079	No	No	No	No	9	9
57	2x42	3x49	Shared	12.3448	16.0138	No	No	No	No	8	9
58	E2x51	E2x52	Shared	13.5919	11.7458	Yes	Yes	Yes	No	6	7
59	E1x50	E2x50	Shared	14.3549	11.5704	Yes	Yes	Yes	No	6	9
60	3x47	5x54	Shared	14.1497	89.3768	No	No	No	No	9	8
61	3x47	5x57	Shared	12.7815	38.2717	No	No	No	No	9	7
62	3x51	5x57	Shared	10.0137	34.4013	Yes	Yes	No	No	8	7
63	E2.W174	E2x51	Shared	27.4732	47.4567	Yes	Yes	Yes	Yes	5	6
64	E2.T168	E2.W169	Shared	14.2549	23.0355	No	Yes	Yes	Yes	6	5
65	E2.P166	E2.Y165	Shared	11.4871	10.0678	No	Yes	Yes	Yes	6	3
66	7x39	Lig	ep4_on	2.38897	10.3075	No	Yes	Yes	Yes	7	0
67	7x46	Lig	ep4_on	0	86.7926	No	No	Yes	Yes	9	0
68	7x45	7x46	ep4_on	0	43.3934	No	No	No	No	9	9
69	6x47	7x43	ep4_on	0	64.938	No	No	No	No	9	5
70	2x50	7x46	ep4_on	0	87.7222	No	Yes	No	No	9	9
71	1x50	2x50	ep4_on	0	100	No	No	No	Yes	9	9
72	1x50	2x51	ep4_on	1.48916	20.884	No	No	No	Yes	9	8
73	1x53	7x50	ep4_on	7.20375	79.4843	No	No	No	No	9	9
74	1x53	7x54	ep4_on	5.78299	77.5491	No	No	No	Yes	9	8
75	1x57	7x54	ep4_on	0	20.311	No	No	No	Yes	8	8
76	1x57	2x40	ep4_on	2.90991	15.7098	No	No	No	No	8	8
77	2x40	I1.K50	ep4_on	0	13.7161	No	No	No	No	8	7
78	7x43	7x48	ep4_on	0	59.7638	No	No	No	No	5	7
79	6x43	7x48	ep4_on	1.45759	58.729	No	No	No	No	6	7
80	6x43	7x52	ep4_on	2.90991	57.6883	No	No	No	No	6	8
81	7x52	7x53	ep4_on	0	55.905	No	No	No	Yes	8	9
82	3x46	7x53	ep4_on	0	19.8667	No	No	No	Yes	9	9
83	2x42	3x46	ep4_on	0	18.0075	No	No	No	No	8	9
84	2x43	7x54	ep4_on	0	41.3704	No	No	No	Yes	8	8
85	2x39	2x43	ep4_on	0	39.2131	Yes	No	No	No	8	8
86	2x46	2x50	ep4_on	0	12.6228	No	No	No	Yes	9	9
87	2x46	3x42	ep4_on	1.43654	15.055	No	No	No	No	9	8
88	2x50	7x49	ep4_on	1.41023	23.6319	No	Yes	No	No	9	9
89	7x45	7x49	ep4_on	2.8152	28.0168	No	No	No	No	9	9
90	3x42	4x50	ep4_on	0	13.2133	No	No	No	Yes	8	8
91	3x35	Lig	ep4_on	0	19.9719	Yes	Yes	Yes	Yes	7	0
92	E2.T168	Lig	ep4_on	0	19.6913	No	Yes	Yes	Yes	6	0
93	2x63	E2.T168	ep4_on	0	38.6693	No	No	No	Yes	7	6
94	2x63	E1x50	ep4_on	0	36.9446	No	No	Yes	Yes	7	6
95	E2.Q164	E2.W169	ep4_on	5.00947	23.439	Yes	No	Yes	Yes	7	5
96	E2.Q164	E2.W174	ep4_on	2.74679	17.0019	Yes	No	Yes	Yes	7	5
97	E2.T175	E2.W174	ep4_on	0	42.8321	No	Yes	Yes	Yes	4	5
98	3x33	5x39	ep4_on	0	16.0723	Yes	Yes	Yes	Yes	7	8
99	5x39	E2x52	ep4_on	0	10.5823	Yes	Yes	Yes	No	8	7
100	3x43	7x53	ep4_on	0	49.3803	No	No	No	Yes	8	9
101	3x44	5x50	ep4_on	2.90991	62.5702	No	No	No	Yes	7	8
102	3x44	5x54	ep4_on	0	60.8396	No	No	No	No	7	8
103	3x47	5x58	ep4_on	0	55.905	No	No	No	Yes	9	9
104	3x50	5x58	ep4_on	0	38.833	Yes	No	No	Yes	9	9
105	3x51	3x55	ep4_on	4.35172	12.2778	Yes	Yes	No	No	8	7
106	3x51	3x56	ep4_on	0	16.7855	Yes	Yes	No	No	8	7
107	3x52	3x56	ep4_on	0	14.7275	No	No	No	No	6	7
108	3x55	5x64	ep4_on	0	10.1906	No	No	No	No	7	7
109	3x52	I2x52	ep4_on	0	12.6579	No	No	No	No	6	5
110	I2x52	I2x56	ep4_on	0	10.5765	No	No	No	No	5	5
111	2x37	2x39	ep4_on	0	16.3237	No	No	Yes	No	7	8
112	2x37	I1.E51	ep4_on	0	14.026	No	No	Yes	No	7	7
113	4x39	I1.E51	ep4_on	0	11.7166	No	No	Yes	No	5	7
114	E2.D173	E2.T175	ep4_on	0.0684066	28.2916	No	Yes	No	Yes	5	4
115	E2.D173	E2.S160	ep4_on	0	12.9794	No	Yes	No	No	5	3
116	5x36	E2.S160	ep4_on	1.5523	10.4069	Yes	Yes	No	No	5	3
117	E2.D173	E2.T176	ep4_on	5.88297	12.9794	No	Yes	No	No	5	4
118	5x36	E2.T176	ep4_on	4.3675	10.4069	Yes	Yes	No	No	5	4
119	7x32	7x35	ep4_on	2.09956	19.8784	No	No	Yes	Yes	2	6
120	6x54	7x33	ep4_on	0.584088	13.6109	Yes	Yes	No	No	6	4
121	6x58	E2.W174	ep4_on	8.4719	13.0203	Yes	Yes	Yes	Yes	6	5
122	5x33	5x36	ep4_on	1.62597	10.4245	No	No	Yes	Yes	3	5
123	3x40	5x47	ep4_on	0	24.8772	No	No	No	No	8	7
124	5x47	6x52	ep4_on	1.64176	23.1759	No	No	No	No	7	7
125	6x52	6x56	ep4_on	3.27826	18.0016	No	No	No	No	7	6
126	5x41	6x56	ep4_on	0	10.939	No	No	No	No	5	6
127	3x50	6x33	ep4_on	1.34182	37.3363	Yes	No	No	No	9	9
128	5x65	6x33	ep4_on	0	35.5999	No	Yes	No	No	9	9
129	5x65	6x30	ep4_on	0	21.9305	No	Yes	No	Yes	9	8
130	5x65	6x34	ep4_on	0	10.5589	No	Yes	No	No	9	7
131	7x32	E3.E303	ep4_on	0	13.7102	No	No	No	No	2	3
132	E3.E303	E3.E305	ep4_on	0	19.0248	No	No	No	No	3	1
133	E3.E305	E3.K308	ep4_on	0	15.242	No	No	No	No	1	4
134	7x54	7x55	ep4_on	0	18.3641	No	Yes	No	No	8	6
135	7x51	7x55	ep4_on	0	13.7804	No	No	No	No	7	6
136	2x39	8x47	ep4_on	0	21.492	Yes	No	No	No	8	9
137	8x47	8x50	ep4_on	1.45759	19.2236	No	No	No	No	9	7
138	1x56	8x50	ep4_on	0	17.2182	No	No	No	No	7	7
139	1x56	8x49	ep4_on	0	14.9146	No	No	No	No	7	7
140	8x49	8x53	ep4_on	0	10.29	No	No	No	No	7	7
141	5x39	E2.L158	ep4_on	1.54178	15.1368	Yes	Yes	No	No	8	5
142	5x69	6x30	ep4_on	0	15.9846	No	No	No	Yes	5	8
143	6x54	7x34	ep4_on	3.58346	12.4708	Yes	Yes	Yes	Yes	6	6
144	7x35	Lig	ep4_on	0.705115	17.8613	Yes	Yes	Yes	Yes	6	0
145	E2.P166	E2.W169	ep4_on	0	10.7051	No	Yes	Yes	Yes	6	5
146	3x43	5x54	ep4_on	0	48.8891	No	No	No	No	8	8
147	7x34	E2.W174	ep4_on	6.10924	11.3482	Yes	Yes	Yes	Yes	6	5

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
1x36	2x64	Shared	3.79	10.0925	0	0	2	1
1x38	1x39	ep4_off	3.39	0	1	0	1	1
1x38	Lig	ep4_off	3.91	0	1	0	1	0
1x39	2x60	ep4_off	3.5	0	1	0	1	1
1x39	2x61	ep4_off	4.235	0	1	0	1	2
1x39	Lig	Shared	3.375	5.485	1	0	1	0
1x42	7x47	ep4_off	4.37	0	0	0	1	2
1x43	2x57	Shared	15.85	13.2125	0	0	2	1
2x50	3x39	ep4_off	20.25	0	4	2	2	2
2x52	3x35	Shared	6.7	2.7425	0	0	2	1
2x53	3x35	Shared	9.03	8.28	0	0	2	1
2x54	2x57	ep4_off	3.2	0	0	0	1	1
2x54	7x46	ep4_off	5.25	0	0	0	1	1
2x57	2x58	Shared	5.34	3.115	0	0	1	2
2x60	Lig	Shared	10.61	9.4175	1	0	1	0
2x64	Lig	Shared	12.855	4.5375	0	1	1	0
3x31	3x35	Shared	5.02	3.7675	6	0	2	1
3x32	E2x51	ep4_off	6.09	0	0	1	1	2
3x32	Lig	Shared	4.74	4.4025	0	1	1	0
3x34	3x35	Shared	12.86	6.965	0	0	2	1
3x39	7x45	ep4_off	11.45	0	4	0	2	2
3x39	7x46	ep4_off	10.09	0	4	0	2	1
E2.Q164	E2.W169	Shared	22.45	20.8075	1	1	2	1
E2.Q164	E2x51	ep4_off	4.095	0	1	1	2	2
E2.P166	E2.T168	Shared	8.74	6.9925	0	1	2	1
E2.T168	E2.W169	Shared	4.85	3.6375	0	1	1	1
E2.W169	E2x51	Shared	5.01	5.0125	1	1	1	2
7x35	E2.W169	ep4_off	5.69	0	1	1	1	1
7x38	E2.W169	Shared	13.505	10.5675	1	1	1	1
E2.W169	Lig	Shared	7.805	7.4425	1	1	1	0
6x47	7x45	Shared	7.085	5.905	0	0	2	2
7x32	7x35	Shared	13.045	3.775	0	1	2	1
7x35	7x39	Shared	4.25	9.11	1	1	1	1
7x35	Lig	Shared	4.74	6.4125	1	1	1	0
7x38	Lig	Shared	10.745	3.5375	1	1	1	0
7x39	Lig	Shared	38.685	7.0425	1	1	1	0
7x42	Lig	Shared	12.85	15	0	0	1	0
7x43	Lig	ep4_off	3.06	0	0	0	1	0
2x56	3x32	Shared	2.98	3.3525	0	1	1	1
1x35	2x64	ep4_off	2.78	0	0	0	2	1
3x36	5x43	ep4_off	2.54	0	0	0	1	2
1x42	Lig	ep4_off	1.94	0	0	0	1	0
1x38	7x39	ep4_on	0	6.575	1	0	1	1
1x42	7x39	ep4_on	0	4.03	0	0	1	1
2x50	7x46	ep4_on	0	6.8425	4	2	2	1
2x54	Lig	ep4_on	0	4.895	0	0	1	0
2x56	3x31	ep4_on	0	5.375	0	1	1	2
2x56	Lig	ep4_on	0	6.63	0	1	1	0
2x57	Lig	ep4_on	0	5.2775	0	0	1	0
2x63	E2.T168	ep4_on	0	3.5325	0	0	2	1
2x64	E2.T168	ep4_on	0	10.925	0	1	1	1
3x36	Lig	ep4_on	0	7.245	0	0	1	0
E2.P166	E2.W169	ep4_on	0	4.7275	0	1	2	1
E2.T168	Lig	ep4_on	0	5.0475	0	1	1	0
7x45	7x46	ep4_on	0	3.6675	4	0	2	1
7x46	Lig	ep4_on	0	4.8825	0	0	1	0
7x35	E2.P166	ep4_on	0	3.285	1	1	1	2
6x47	7x43	ep4_on	0	3.4175	0	0	2	1
7x43	7x47	ep4_on	0	3.0725	0	0	1	2
3x35	Lig	ep4_on	0	6.72	0	0	1	0
1x43	2x61	ep4_on	0	2.5125	0	0	2	2
1x35	1x37	ep4_on	0	2.185	0	0	2	2
7x43	7x48	ep4_on	0	1.8625	0	0	1	2
1x37	1x38	ep4_on	0	1.52	0	0	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	ep4_off	5YWY-EP₄-ONO-AE3-208 5YHL-EP₄-PubChem 135121352
	ep4_on	7D7M-EP₄-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP₄-PGE2-Gi1/&β;1/&γ;2 8GD9-EP₄-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP₄-L902688-Gs/&β;1/&γ;2

Network Difference
Value	ep4_off	ep4_on
I_min	3.06	3.01
Number of Linked Nodes	252	280
Number of Specific Nodes	2 (0.79%)	30 (10.71%)
Number of Shared Nodes	250 (99.21%)	250 (89.29%)
Number of Links	279	305
Number of Specific Links	131 (46.95%)	157 (51.48%)
Number of Shared Links	148 (53.05%)	148 (48.52%)
Number of Hubs	34	33
Number of Specific Hubs	18 (52.94%)	17 (51.52%)
Number of Shared Hubs	16 (47.06%)	16 (48.48%)
Average % Shared Neighbours (Jaccard)	37.30
Average % Shared Neighbours (Otsuka)	45.75
Average % Shared Neighbours (Overlap Coefficient)	53.40
Average % Shared Cliques (k3-6)	78.95
Graphlets Similarity	0.580809

Paths Difference
Value	ep4_off	ep4_on
Number Of Nodes in MetaPath	66	96
Specific Nodes in MetaPath	29 (43.94%)	59 (61.46%)
Shared Nodes in MetaPath	250 (99.21%)	250 (99.21%)
Number Of Links MetaPath	65	101
Specific Links in MetaPath	46 (70.77%)	82 (81.19%)
Shared Links in MetaPath	148 (53.05%)	148 (53.05%)
Number of Shortest Paths	36868	53745
Length Of Smallest Path	3	3
Average Path Length	14.6569	14.1809
Length of Longest Path	30	35
Minimum Path Strength	1.395	0.525
Average Path Strength	6.66117	4.64625
Maximum Path Strength	25.77	15.6875
Minimum Path Correlation	0.7	0.7
Average Path Correlation	0.920838	0.920763
Maximum Path Correlation	0.99	0.9925
Minimum % Of Corr. Nodes	4	3.0303
Average % Of Corr. Nodes	43.9585	47.3206
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	33.8732	35.453
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download ep4_off_on.zip<

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