psnGPCR

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Orange: nodes, hubs and links specific of ep_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of ep_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	ep_off Int. Strength	ep_on Int. Strength	ep_off Hub1?	ep_on Hub1?	ep_off Hub2?	ep_on Hub2?	ConSurf1	ConSurf2
1	1x33	1x34	ep_off	100	0	No	No	No	No	4	1
2	1x38	1x39	ep_off	100	0	No	No	Yes	No	6	7
3	1x38	Lig	ep_off	100	0	No	No	Yes	Yes	6	0
4	1x39	2x60	ep_off	100	0	Yes	No	No	No	7	8
5	1x42	7x47	ep_off	100	0	No	No	No	No	8	8
6	1x43	2x55	ep_off	100	0	No	No	No	No	6	5
7	1x45	7x47	ep_off	100	0	No	No	No	No	5	8
8	1x50	2x47	ep_off	100	0	No	No	No	No	9	8
9	1x54	2x44	ep_off	100	0	Yes	No	No	No	8	6
10	1x54	2x48	ep_off	100	0	Yes	No	No	No	8	5
11	1x57	2x40	ep_off	100	0	No	No	No	No	8	8
12	1x59	I1	ep_off	100	0	No	No	Yes	Yes	6	6
13	2x37	I1	ep_off	100	0	No	No	Yes	Yes	7	6
14	I1	I2x53	ep_off	100	0	Yes	Yes	Yes	Yes	6	8
15	6x29	I1	ep_off	100	0	No	Yes	Yes	Yes	7	6
16	6x30	I1	ep_off	100	0	No	Yes	Yes	Yes	8	6
17	6x33	I1	ep_off	100	0	No	No	Yes	Yes	9	6
18	2x38	2x41	ep_off	100	0	No	No	No	No	6	6
19	2x38	4x38	ep_off	100	0	No	No	Yes	No	6	8
20	2x39	3x50	ep_off	100	0	Yes	No	Yes	No	8	9
21	2x39	6x33	ep_off	100	0	Yes	No	No	No	8	9
22	2x39	6x37	ep_off	100	0	Yes	No	No	Yes	8	8
23	2x40	6x36	ep_off	100	0	No	No	No	No	8	8
24	2x42	4x46	ep_off	100	0	No	No	No	No	8	8
25	2x43	7x53	ep_off	100	0	No	No	No	Yes	8	9
26	2x45	2x48	ep_off	100	0	No	No	No	No	8	5
27	2x50	3x39	ep_off	100	0	No	Yes	Yes	No	9	9
28	2x50	7x49	ep_off	100	0	No	Yes	No	Yes	9	9
29	2x52	2x551	ep_off	100	0	No	No	No	No	7	6
30	2x54	2x57	ep_off	100	0	No	No	No	No	8	8
31	2x54	7x46	ep_off	100	0	No	No	No	No	8	9
32	2x551	3x31	ep_off	100	0	No	No	No	No	6	5
33	E1x50	E1x51	ep_off	100	0	Yes	No	Yes	No	6	4
34	E1x50	E2x50	ep_off	100	0	Yes	No	No	No	6	9
35	3x24	E1x52	ep_off	100	0	No	No	No	No	6	5
36	3x22	3x23	ep_off	100	0	No	No	No	No	2	2
37	3x25	E2	ep_off	100	0	No	No	Yes	Yes	9	5
38	3x30	4x61	ep_off	100	0	No	No	No	No	7	5
39	3x33	4x57	ep_off	100	0	Yes	No	No	No	7	8
40	3x33	E2x52	ep_off	100	0	Yes	No	No	No	7	7
41	3x33	5x43	ep_off	100	0	Yes	No	No	No	7	7
42	3x34	3x38	ep_off	100	0	Yes	Yes	No	No	7	8
43	3x37	4x56	ep_off	100	0	Yes	No	No	No	8	7
44	3x37	5x46	ep_off	100	0	Yes	No	No	No	8	6
45	3x38	4x53	ep_off	100	0	No	No	No	No	8	8
46	3x39	7x45	ep_off	100	0	Yes	No	No	Yes	9	9
47	3x39	7x49	ep_off	100	0	Yes	No	No	Yes	9	9
48	3x40	5x51	ep_off	100	0	No	No	Yes	No	8	7
49	3x41	4x53	ep_off	100	0	No	No	No	No	7	8
50	3x42	4x46	ep_off	100	0	No	No	No	No	8	8
51	3x43	3x46	ep_off	100	0	No	No	No	Yes	8	9
52	3x43	6x41	ep_off	100	0	No	No	No	No	8	8
53	3x43	6x44	ep_off	100	0	No	No	No	No	8	8
54	3x44	5x50	ep_off	100	0	No	No	No	No	7	8
55	3x47	5x54	ep_off	100	0	No	No	No	No	9	8
56	3x49	3x50	ep_off	100	0	No	No	Yes	No	9	9
57	3x49	4x38	ep_off	100	0	No	No	Yes	No	9	8
58	3x50	I2x53	ep_off	100	0	Yes	No	Yes	Yes	9	8
59	3x50	4x38	ep_off	100	0	Yes	No	Yes	No	9	8
60	3x50	6x33	ep_off	100	0	Yes	No	No	No	9	9
61	3x51	3x52	ep_off	100	0	Yes	Yes	No	No	8	6
62	3x51	5x60	ep_off	100	0	Yes	Yes	No	No	8	5
63	3x55	3x56	ep_off	100	0	No	No	No	No	7	7
64	3x56	I2x52	ep_off	100	0	No	No	No	No	7	5
65	I2x51	I2x54	ep_off	100	0	No	No	No	No	7	6
66	4x38	I2x53	ep_off	100	0	Yes	No	Yes	Yes	8	8
67	4x40	I2x56	ep_off	100	0	No	Yes	No	No	5	5
68	4x41	I2x56	ep_off	100	0	No	No	No	No	5	5
69	4x38	I2x57	ep_off	100	0	Yes	No	No	No	8	7
70	4x43	4x46	ep_off	100	0	No	No	No	No	5	8
71	4x56	5x46	ep_off	100	0	No	No	No	No	7	6
72	4x59	4x60	ep_off	100	0	Yes	No	No	No	8	9
73	4x59	5x39	ep_off	100	0	Yes	No	Yes	Yes	8	8
74	6x51	E2x51	ep_off	100	0	No	No	Yes	Yes	7	6
75	5x40	E2x52	ep_off	100	0	No	No	No	No	7	7
76	6x55	E2	ep_off	100	0	No	No	Yes	Yes	7	5
77	6x59	E2	ep_off	100	0	Yes	No	Yes	Yes	6	5
78	5x33	E2	ep_off	100	0	No	No	Yes	Yes	3	5
79	5x39	5x42	ep_off	100	0	Yes	Yes	No	No	8	5
80	5x44	6x55	ep_off	100	0	No	No	No	No	7	7
81	5x51	6x45	ep_off	100	0	Yes	No	No	No	7	6
82	5x51	6x49	ep_off	100	0	Yes	No	No	No	7	7
83	5x54	6x41	ep_off	100	0	No	No	No	No	8	8
84	5x54	6x45	ep_off	100	0	No	No	No	No	8	6
85	5x56	5x60	ep_off	100	0	No	No	No	No	4	5
86	5x58	6x38	ep_off	100	0	No	Yes	Yes	No	9	7
87	5x61	6x34	ep_off	100	0	No	No	No	No	9	7
88	6x29	6x32	ep_off	100	0	No	Yes	No	No	7	8
89	6x31	8x55	ep_off	100	0	No	No	No	No	6	4
90	6x32	8x48	ep_off	100	0	No	No	No	No	8	6
91	6x36	7x53	ep_off	100	0	No	No	No	Yes	8	9
92	6x36	7x56	ep_off	100	0	No	No	No	No	8	8
93	6x37	6x41	ep_off	100	0	No	Yes	No	No	8	8
94	6x40	7x52	ep_off	100	0	No	No	No	No	8	8
95	6x43	7x52	ep_off	100	0	No	No	No	No	6	8
96	6x47	7x40	ep_off	100	0	No	No	No	No	9	8
97	6x51	7x37	ep_off	100	0	No	No	No	No	7	7
98	6x58	E3	ep_off	100	0	Yes	No	Yes	Yes	6	2
99	6x58	7x34	ep_off	100	0	Yes	No	Yes	No	6	6
100	7x32	7x33	ep_off	100	0	No	No	No	No	2	4
101	7x32	7x35	ep_off	100	0	No	No	Yes	No	2	6
102	7x33	7x34	ep_off	100	0	No	No	Yes	No	4	6
103	7x38	Lig	ep_off	100	0	No	No	Yes	Yes	6	0
104	7x56	8x51	ep_off	100	0	No	No	No	No	8	7
105	8x47	8x50	ep_off	100	0	No	No	No	No	9	7
106	8x51	8x55	ep_off	100	0	No	No	No	No	7	4
107	3x42	4x49	ep_off	50	0	No	No	No	No	8	7
108	6x34	6x38	ep_off	50	0	No	No	Yes	No	7	7
109	7x43	Lig	ep_off	50	0	No	No	Yes	Yes	5	0
110	1x36	2x65	ep_off	50	0	No	No	No	No	6	4
111	2x43	3x46	ep_off	50	0	No	No	No	Yes	8	9
112	5x48	5x52	ep_off	50	0	No	No	No	No	6	4
113	1x56	1x57	ep_off	50	0	No	No	No	No	7	8
114	2x43	2x47	ep_off	50	0	No	No	No	No	8	8
115	2x56	3x32	ep_off	50	0	No	No	No	No	7	8
116	8x58	8x59	ep_off	0	0	No	No	No	No	5	4
117	1x51	1x54	ep_off	0	0	No	No	Yes	No	5	8
118	3x54	5x65	ep_off	0	0	No	No	No	No	9	9
119	6x38	6x42	ep_off	0	0	Yes	No	No	No	7	6
120	1x35	2x64	ep_off	0	0	No	No	No	No	5	6
121	7x50	7x51	ep_off	0	0	No	Yes	No	No	9	7
122	3x51	5x57	ep_off	0	0	Yes	Yes	No	No	8	7
123	5x48	6x56	ep_off	0	0	No	No	No	No	6	6
124	5x68	5x69	ep_off	0	0	No	No	No	Yes	7	5
125	6x52	6x56	ep_off	0	0	No	No	No	No	7	6
126	3x22	3x26	ep_off	0	0	No	No	No	No	2	6
127	3x36	5x43	ep_off	0	0	No	No	No	No	7	7
128	3x28	E1x50	ep_off	0	0	No	No	Yes	No	6	6
129	3x30	4x58	ep_off	0	0	No	No	No	No	7	6
130	5x62	5x63	ep_off	0	0	No	No	No	No	7	3
131	4x42	4x43	ep_off	0	0	No	No	No	No	8	5
132	1x53	7x50	ep_off	0	0	No	No	No	Yes	9	9
133	2x62	E1x51	ep_off	0	0	No	No	Yes	No	6	4
134	5x45	5x48	ep_off	0	0	No	No	No	No	5	6
135	2x63	E1x51	ep_off	0	0	No	No	Yes	No	7	4
136	4x59	4x63	ep_off	0	0	Yes	No	No	No	8	8
137	5x33	5x35	ep_off	0	0	No	No	No	No	3	3
138	5x62	6x38	ep_off	0	0	No	No	Yes	No	7	7
139	1x40	2x61	ep_off	0	0	No	No	No	No	5	6
140	3x54	5x64	ep_off	0	0	No	No	No	No	9	7
141	6x39	7x52	ep_off	0	0	No	No	No	No	6	8
142	5x55	5x59	ep_off	0	0	No	No	No	No	6	4
143	6x53	6x57	ep_off	0	0	No	No	No	No	7	5
144	1x37	1x41	ep_off	0	0	No	No	No	No	5	5
145	1x44	1x48	ep_off	0	0	No	No	No	No	5	5
146	1x52	7x54	ep_off	0	0	No	No	No	No	6	8
147	5x51	5x55	ep_off	0	0	Yes	No	No	No	7	6
148	4x41	I2x57	ep_off	0	0	No	No	No	No	5	7
149	4x54	4x55	ep_off	0	0	No	No	No	No	4	4
150	7x54	8x47	ep_off	0	0	No	No	No	No	8	9
151	8x52	8x56	ep_off	0	0	No	No	No	No	5	4
152	1x36	2x64	Shared	100	100	No	No	No	No	6	6
153	1x39	2x61	Shared	100	33.3333	Yes	No	No	No	7	6
154	1x39	Lig	Shared	100	100	Yes	No	Yes	Yes	7	0
155	1x41	1x45	Shared	100	33.3333	No	No	No	No	5	5
156	1x43	1x47	Shared	100	55.5556	No	No	No	No	6	7
157	1x43	2x57	Shared	100	100	No	No	No	No	6	8
158	1x48	1x49	Shared	100	16.6667	No	No	No	No	5	9
159	1x50	2x51	Shared	100	100	No	No	No	No	9	8
160	1x50	7x50	Shared	100	100	No	No	No	Yes	9	9
161	1x51	2x51	Shared	100	33.3333	No	No	No	No	5	8
162	1x53	7x54	Shared	100	16.6667	No	No	No	No	9	8
163	I1	I1	Shared	100	100	Yes	Yes	Yes	Yes	6	6
164	2x39	3x46	Shared	100	19.4444	Yes	No	No	Yes	8	9
165	2x42	3x49	Shared	100	41.6667	No	No	No	No	8	9
166	2x46	3x42	Shared	100	100	No	Yes	No	No	9	8
167	2x49	4x50	Shared	100	100	No	No	No	Yes	9	8
168	2x52	3x35	Shared	100	100	No	No	Yes	Yes	7	7
169	2x53	3x35	Shared	100	100	No	No	Yes	Yes	8	7
170	2x551	3x27	Shared	100	61.1111	No	No	No	No	6	5
171	2x57	2x58	Shared	100	100	No	No	No	No	8	9
172	2x59	3x28	Shared	100	41.6667	No	No	No	No	7	6
173	2x60	Lig	Shared	100	100	No	No	Yes	Yes	8	0
174	2x64	Lig	Shared	100	100	No	No	Yes	Yes	6	0
175	3x24	E1x50	Shared	100	100	No	No	Yes	No	6	6
176	E1x50	E2	Shared	100	100	Yes	No	Yes	Yes	6	5
177	3x25	E2x50	Shared	100	100	No	No	No	No	9	9
178	3x26	E2	Shared	100	100	No	No	Yes	Yes	6	5
179	3x27	3x31	Shared	100	100	No	No	No	No	5	5
180	3x29	E2	Shared	100	100	No	No	Yes	Yes	7	5
181	3x31	3x35	Shared	100	100	No	No	Yes	Yes	5	7
182	3x32	E2x51	Shared	100	100	No	No	Yes	Yes	8	6
183	3x32	Lig	Shared	100	100	No	No	Yes	Yes	8	0
184	3x33	E2x51	Shared	100	66.6667	Yes	No	Yes	Yes	7	6
185	3x34	3x35	Shared	100	100	Yes	Yes	Yes	Yes	7	7
186	3x34	4x50	Shared	100	100	Yes	Yes	No	Yes	7	8
187	3x34	4x54	Shared	100	100	Yes	Yes	No	No	7	4
188	3x37	4x53	Shared	100	100	Yes	No	No	No	8	8
189	3x37	5x43	Shared	100	100	Yes	No	No	No	8	7
190	3x39	7x46	Shared	100	100	Yes	No	No	No	9	9
191	3x40	5x50	Shared	100	41.6667	No	No	No	No	8	8
192	3x40	6x48	Shared	100	100	No	No	No	Yes	8	8
193	3x47	5x57	Shared	100	33.3333	No	No	No	No	9	7
194	3x48	5x57	Shared	100	41.6667	No	No	No	No	7	7
195	3x51	3x55	Shared	100	100	Yes	Yes	No	No	8	7
196	I2x53	I2x57	Shared	100	100	Yes	Yes	No	No	8	7
197	I2x55	I2x56	Shared	100	100	No	No	No	No	5	5
198	4x56	5x42	Shared	100	41.6667	No	No	No	No	7	5
199	4x59	E2	Shared	100	100	Yes	No	Yes	Yes	8	5
200	4x60	E2	Shared	100	100	No	No	Yes	Yes	9	5
201	4x60	5x39	Shared	100	100	No	No	Yes	Yes	9	8
202	5x39	E2	Shared	100	100	Yes	Yes	Yes	Yes	8	5
203	5x36	E2	Shared	100	100	No	No	Yes	Yes	5	5
204	E2	E2x50	Shared	100	66.6667	Yes	Yes	No	No	5	9
205	E2	E2	Shared	100	100	Yes	Yes	Yes	Yes	5	5
206	E2	E2x51	Shared	100	100	Yes	Yes	Yes	Yes	5	6
207	E2	E3	Shared	100	100	Yes	Yes	Yes	Yes	5	2
208	E2	Lig	Shared	100	100	Yes	Yes	Yes	Yes	5	0
209	7x34	E2	Shared	100	100	Yes	No	Yes	Yes	6	5
210	7x35	E2	Shared	100	100	Yes	No	Yes	Yes	6	5
211	7x38	E2	Shared	100	100	No	No	Yes	Yes	6	5
212	E2x51	E2x52	Shared	100	100	Yes	Yes	No	No	6	7
213	6x58	E2	Shared	100	100	Yes	No	Yes	Yes	6	5
214	5x33	5x36	Shared	100	100	No	No	No	No	3	5
215	5x37	6x59	Shared	100	100	No	No	Yes	No	5	6
216	5x40	6x59	Shared	100	100	No	No	Yes	No	7	6
217	5x41	6x59	Shared	100	100	No	No	Yes	No	5	6
218	5x41	6x60	Shared	100	8.33333	No	No	No	No	5	4
219	5x44	6x56	Shared	100	100	No	No	No	No	7	6
220	5x46	5x50	Shared	100	33.3333	No	No	No	No	6	8
221	5x47	6x52	Shared	100	33.3333	No	No	No	No	7	7
222	5x58	6x37	Shared	100	100	No	Yes	No	Yes	9	8
223	6x35	8x51	Shared	100	33.3333	No	No	No	No	7	7
224	6x40	7x53	Shared	100	100	No	No	No	Yes	8	9
225	6x47	7x45	Shared	100	100	No	No	No	Yes	9	9
226	6x49	6x50	Shared	100	58.3333	No	No	No	No	7	9
227	6x50	7x40	Shared	100	100	No	No	No	No	9	8
228	6x54	6x57	Shared	100	100	Yes	Yes	No	No	6	5
229	6x54	6x58	Shared	100	100	Yes	Yes	Yes	No	6	6
230	6x54	7x33	Shared	100	100	Yes	Yes	No	No	6	4
231	6x54	7x34	Shared	100	100	Yes	Yes	Yes	No	6	6
232	6x60	6x61	Shared	100	33.3333	No	No	No	No	4	4
233	E3	E3	Shared	100	100	Yes	Yes	Yes	Yes	2	2
234	7x35	7x39	Shared	100	100	Yes	No	No	Yes	6	7
235	7x35	Lig	Shared	100	100	Yes	No	Yes	Yes	6	0
236	7x39	Lig	Shared	100	100	No	Yes	Yes	Yes	7	0
237	7x42	Lig	Shared	100	100	No	No	Yes	Yes	8	0
238	7x45	7x49	Shared	100	100	No	Yes	No	Yes	9	9
239	8x49	8x53	Shared	100	8.33333	No	No	No	No	7	7
240	3x54	5x61	Shared	50	33.3333	No	No	No	No	9	9
241	6x43	7x48	Shared	50	19.4444	No	No	No	No	6	7
242	6x32	8x52	Shared	0	33.3333	No	No	No	No	8	5
243	1x54	2x47	Shared	0	11.1111	Yes	No	No	No	8	8
244	3x30	4x57	Shared	0	100	No	No	No	No	7	8
245	1x34	1x35	Shared	50	33.3333	No	No	No	No	1	5
246	3x53	I2x53	Shared	0	100	No	No	Yes	Yes	9	8
247	I2x51	I2x55	Shared	0	0	No	No	No	No	7	5
248	3x21	E1x52	Shared	0	0	No	No	No	No	5	5
249	1x42	Lig	Shared	0	100	No	No	Yes	Yes	8	0
250	3x44	5x53	Shared	0	33.3333	No	No	No	No	7	6
251	1x46	7x47	Shared	0	100	No	No	No	No	8	8
252	3x45	4x45	Shared	0	0	No	No	No	No	8	7
253	2x66	E1x51	Shared	0	33.3333	No	No	Yes	No	5	4
254	6x46	6x47	Shared	0	33.3333	No	No	No	No	7	9
255	1x58	1x59	Shared	0	8.33333	No	No	No	No	4	6
256	4x45	4x49	Shared	0	0	No	No	No	No	7	7
257	1x49	7x51	Shared	0	33.3333	No	No	No	No	9	7
258	1x38	7x39	ep_on	0	100	No	No	No	Yes	6	7
259	1x42	7x39	ep_on	0	100	No	No	No	Yes	8	7
260	1x50	2x50	ep_on	0	100	No	No	No	Yes	9	9
261	1x57	2x44	ep_on	0	100	No	No	No	No	8	6
262	2x40	I1	ep_on	0	100	No	No	Yes	Yes	8	6
263	2x38	3x49	ep_on	0	100	No	No	No	No	6	9
264	2x38	I2x53	ep_on	0	100	No	No	Yes	Yes	6	8
265	2x39	2x43	ep_on	0	100	Yes	No	No	No	8	8
266	2x42	3x46	ep_on	0	100	No	No	No	Yes	8	9
267	2x45	4x46	ep_on	0	100	No	No	No	No	8	8
268	2x46	3x46	ep_on	0	100	No	Yes	No	Yes	9	9
269	2x46	7x49	ep_on	0	100	No	Yes	No	Yes	9	9
270	2x49	3x38	ep_on	0	100	No	No	No	No	9	8
271	2x50	7x46	ep_on	0	100	No	Yes	No	No	9	9
272	2x50	7x50	ep_on	0	100	No	Yes	No	Yes	9	9
273	2x54	Lig	ep_on	0	100	No	No	Yes	Yes	8	0
274	2x56	3x31	ep_on	0	100	No	No	No	No	7	5
275	2x56	Lig	ep_on	0	100	No	No	Yes	Yes	7	0
276	2x57	Lig	ep_on	0	100	No	No	Yes	Yes	8	0
277	2x64	E2	ep_on	0	100	No	No	Yes	Yes	6	5
278	3x34	4x53	ep_on	0	100	Yes	Yes	No	No	7	8
279	3x34	4x57	ep_on	0	100	Yes	Yes	No	No	7	8
280	3x36	Lig	ep_on	0	100	No	No	Yes	Yes	7	0
281	3x41	4x49	ep_on	0	100	No	No	No	No	7	7
282	3x43	7x49	ep_on	0	100	No	No	No	Yes	8	9
283	3x46	7x53	ep_on	0	100	No	Yes	No	Yes	9	9
284	3x49	I2x53	ep_on	0	100	No	No	Yes	Yes	9	8
285	3x50	6x37	ep_on	0	100	Yes	No	No	Yes	9	8
286	3x51	3x56	ep_on	0	100	Yes	Yes	No	No	8	7
287	3x55	5x64	ep_on	0	100	No	No	No	No	7	7
288	I2x52	I2x56	ep_on	0	100	No	No	No	No	5	5
289	4x46	4x50	ep_on	0	100	No	No	No	Yes	8	8
290	4x56	5x39	ep_on	0	100	No	No	Yes	Yes	7	8
291	5x39	E2x52	ep_on	0	100	Yes	Yes	No	No	8	7
292	5x55	6x45	ep_on	0	100	No	No	No	No	6	6
293	5x58	6x41	ep_on	0	100	No	Yes	No	No	9	8
294	5x65	6x30	ep_on	0	100	No	No	No	Yes	9	8
295	6x51	7x41	ep_on	0	100	No	No	No	No	7	8
296	6x54	7x37	ep_on	0	100	Yes	Yes	No	No	6	7
297	7x32	E3	ep_on	0	100	No	No	Yes	Yes	2	2
298	7x33	E3	ep_on	0	100	No	No	Yes	Yes	4	2
299	7x46	Lig	ep_on	0	100	No	No	Yes	Yes	9	0
300	7x49	7x50	ep_on	0	100	No	Yes	No	Yes	9	9
301	7x49	7x53	ep_on	0	100	No	Yes	No	Yes	9	9
302	7x51	7x55	ep_on	0	100	No	No	No	Yes	7	6
303	2x46	2x50	ep_on	0	100	No	Yes	No	Yes	9	9
304	3x43	7x53	ep_on	0	100	No	No	No	Yes	8	9
305	4x58	4x61	ep_on	0	100	No	No	No	No	6	5
306	5x69	6x30	ep_on	0	100	No	Yes	No	Yes	5	8
307	6x36	8x47	ep_on	0	100	No	No	No	No	8	9
308	6x48	7x45	ep_on	0	100	No	Yes	No	Yes	8	9
309	2x56	3x28	ep_on	0	100	No	No	No	No	7	6
310	4x40	4x43	ep_on	0	100	No	Yes	No	No	5	5
311	2x60	E2	ep_on	0	100	No	No	Yes	Yes	8	5
312	E1	E1	ep_on	0	100	No	Yes	No	Yes	4	4
313	3x24	E1	ep_on	0	100	No	No	No	Yes	6	4
314	3x23	3x26	ep_on	0	100	No	No	No	No	2	6
315	4x60	5x37	ep_on	0	100	No	No	No	No	9	5
316	5x41	5x45	ep_on	0	100	No	No	No	No	5	5
317	5x52	6x44	ep_on	0	100	No	No	No	No	4	8
318	5x67	6x30	ep_on	0	100	No	No	No	Yes	4	8
319	6x33	8x48	ep_on	0	100	No	No	No	No	9	6
320	7x34	E3	ep_on	0	100	Yes	No	Yes	Yes	6	2
321	8x52	8x55	ep_on	0	100	No	No	No	No	5	4
322	4x47	4x50	ep_on	0	100	No	No	No	Yes	4	8
323	4x50	4x51	ep_on	0	100	No	Yes	No	No	8	4
324	6x26	6x29	ep_on	0	100	No	No	No	Yes	0	7
325	2x40	2x44	ep_on	0	33.3333	No	No	No	No	8	6
326	2x63	E1x50	ep_on	0	33.3333	No	No	Yes	No	7	6
327	E1x49	E1x51	ep_on	0	33.3333	No	No	Yes	No	4	4
328	3x26	4x61	ep_on	0	33.3333	No	No	No	No	6	5
329	2x43	7x54	ep_on	0	66.6667	No	No	No	No	8	8
330	5x56	6x41	ep_on	0	33.3333	No	No	No	No	4	8
331	6x47	7x43	ep_on	0	55.5556	No	No	No	No	9	5
332	3x50	6x40	ep_on	0	66.6667	Yes	No	No	No	9	8
333	6x48	7x41	ep_on	0	33.3333	No	Yes	No	No	8	8
334	6x44	7x45	ep_on	0	66.6667	No	No	No	Yes	8	9
335	5x51	6x48	ep_on	0	33.3333	Yes	No	No	Yes	7	8
336	7x43	7x47	ep_on	0	66.6667	No	No	No	No	5	8
337	7x51	7x56	ep_on	0	41.6667	No	No	No	No	7	8
338	7x52	7x53	ep_on	0	44.4444	No	No	No	Yes	8	9
339	3x52	I2x52	ep_on	0	41.6667	No	No	No	No	6	5
340	3x47	5x58	ep_on	0	33.3333	No	No	No	Yes	9	9
341	E1x49	E2	ep_on	0	41.6667	No	No	Yes	Yes	4	5
342	1x57	2x43	ep_on	0	41.6667	No	No	No	No	8	8
343	2x67	E1	ep_on	0	33.3333	No	No	No	Yes	0	4
344	6x38	6x41	ep_on	0	33.3333	Yes	No	No	No	7	8
345	5x60	6x37	ep_on	0	33.3333	No	No	No	Yes	5	8
346	8x53	8x57	ep_on	0	33.3333	No	No	No	No	7	4
347	4x61	4x62	ep_on	0	33.3333	No	No	No	No	5	5
348	2x38	4x42	ep_on	0	16.6667	No	No	No	No	6	8
349	3x51	5x58	ep_on	0	33.3333	Yes	Yes	No	Yes	8	9
350	6x32	8x51	ep_on	0	33.3333	No	No	No	No	8	7
351	6x53	6x54	ep_on	0	33.3333	No	No	Yes	Yes	7	6
352	1x60	I1	ep_on	0	33.3333	No	No	Yes	Yes	6	6
353	5x49	6x44	ep_on	0	33.3333	No	No	No	No	4	8
354	5x65	6x33	ep_on	0	33.3333	No	No	No	No	9	9
355	5x38	E2x52	ep_on	0	33.3333	No	No	No	No	5	7
356	I2x52	I2x57	ep_on	0	33.3333	No	No	No	No	5	7
357	5x61	5x65	ep_on	0	50	No	No	No	No	9	9
358	2x51	2x55	ep_on	0	8.33333	No	No	No	No	8	5
359	6x45	6x49	ep_on	0	50	No	No	No	No	6	7
360	5x67	5x71	ep_on	0	41.6667	No	No	No	No	4	0
361	8x48	8x49	ep_on	0	33.3333	No	No	No	No	6	7
362	3x51	5x55	ep_on	0	33.3333	Yes	Yes	No	No	8	6
363	6x29	8x52	ep_on	0	33.3333	No	Yes	No	No	7	5
364	5x64	6x34	ep_on	0	33.3333	No	No	No	No	7	7
365	7x55	8x49	ep_on	0	33.3333	No	Yes	No	No	6	7
366	5x49	5x53	ep_on	0	33.3333	No	No	No	No	4	6
367	E1x49	E1x52	ep_on	0	33.3333	No	No	No	No	4	5
368	2x41	2x45	ep_on	0	11.1111	No	No	No	No	6	8
369	5x51	6x52	ep_on	0	33.3333	Yes	No	No	No	7	7
370	3x41	5x48	ep_on	0	33.3333	No	No	No	No	7	6
371	5x48	6x52	ep_on	0	33.3333	No	No	No	No	6	7
372	5x42	6x56	ep_on	0	33.3333	No	No	No	No	5	6
373	8x55	8x58	ep_on	0	33.3333	No	No	No	No	4	5
374	I2x54	I2x55	ep_on	0	33.3333	No	No	No	No	6	5
375	3x22	E1	ep_on	0	33.3333	No	No	No	Yes	2	4
376	8x53	8x56	ep_on	0	33.3333	No	No	No	No	7	4
377	3x44	5x54	ep_on	0	33.3333	No	No	No	No	7	8
378	5x69	5x73	ep_on	0	33.3333	No	Yes	No	No	5	0
379	6x29	6x33	ep_on	0	22.2222	No	Yes	No	No	7	9
380	6x43	7x45	ep_on	0	33.3333	No	No	No	Yes	6	9
381	1x35	1x36	ep_on	0	33.3333	No	No	No	No	5	6
382	2x47	7x50	ep_on	0	33.3333	No	No	No	Yes	8	9
383	1x52	7x55	ep_on	0	8.33333	No	No	No	Yes	6	6
384	3x54	5x59	ep_on	0	33.3333	No	No	No	No	9	4
385	5x62	6x37	ep_on	0	33.3333	No	No	No	Yes	7	8
386	5x35	E2	ep_on	0	30.5556	No	No	Yes	Yes	3	5
387	5x72	5x76	ep_on	0	33.3333	No	Yes	No	No	0	0
388	4x38	4x40	ep_on	0	33.3333	Yes	No	No	Yes	8	5
389	1x35	1x37	ep_on	0	19.4444	No	No	No	No	5	5
390	2x41	4x43	ep_on	0	33.3333	No	No	No	No	6	5
391	3x53	3x54	ep_on	0	0	No	No	No	No	9	9
392	7x36	7x39	ep_on	0	33.3333	No	No	No	Yes	3	7
393	2x39	8x47	ep_on	0	19.4444	Yes	No	No	No	8	9
394	2x48	4x50	ep_on	0	33.3333	No	No	No	Yes	5	8
395	2x37	2x40	ep_on	0	0	No	No	No	No	7	8
396	6x27	6x30	ep_on	0	33.3333	No	No	No	Yes	6	8
397	4x39	4x40	ep_on	0	33.3333	No	No	No	Yes	5	5
398	5x64	5x68	ep_on	0	33.3333	No	No	No	No	7	7
399	6x42	6x46	ep_on	0	33.3333	No	No	No	No	6	7
400	5x66	5x69	ep_on	0	33.3333	No	No	No	Yes	6	5
401	1x56	7x55	ep_on	0	16.6667	No	No	No	Yes	7	6
402	5x63	6x34	ep_on	0	33.3333	No	No	No	No	3	7
403	5x69	6x31	ep_on	0	33.3333	No	Yes	No	No	5	6
404	5x70	5x74	ep_on	0	33.3333	No	No	No	No	0	0
405	3x56	I2x50	ep_on	0	0	No	No	No	No	7	9
406	1x36	1x40	ep_on	0	22.2222	No	No	No	No	6	5
407	1x41	1x42	ep_on	0	33.3333	No	No	No	No	5	8
408	5x43	6x55	ep_on	0	0	No	No	No	No	7	7
409	1x55	1x59	ep_on	0	33.3333	No	No	No	No	5	6
410	6x28	6x30	ep_on	0	11.1111	No	No	No	Yes	5	8
411	5x72	5x75	ep_on	0	16.6667	No	Yes	No	No	0	0
412	5x66	5x70	ep_on	0	33.3333	No	No	No	No	6	0
413	4x48	4x50	ep_on	0	33.3333	No	No	No	Yes	2	8
414	1x56	8x50	ep_on	0	16.6667	No	No	No	No	7	7
415	2x65	2x66	ep_on	0	8.33333	No	No	No	No	4	5
416	5x72	5x73	ep_on	0	16.6667	No	Yes	No	No	0	0
417	1x44	1x45	ep_on	0	8.33333	No	No	No	No	5	5
418	4x38	4x41	ep_on	0	16.6667	Yes	No	No	No	8	5
419	5x72	6x24	ep_on	0	8.33333	No	Yes	No	No	0	0
420	2x62	2x66	ep_on	0	16.6667	No	No	No	No	6	5
421	6x39	6x42	ep_on	0	0	No	No	No	No	6	6
422	7x39	NT	ep_on	0	11.1111	No	Yes	No	No	7	0
423	3x41	4x52	ep_on	0	0	No	No	No	No	7	5
424	1x54	1x58	ep_on	0	0	Yes	No	No	No	8	4
425	6x25	6x29	ep_on	0	0	No	No	No	Yes	0	7
426	4x40	4x44	ep_on	0	8.33333	No	Yes	No	No	5	4
427	8x50	8x54	ep_on	0	0	No	No	No	No	7	5
428	4x63	E2	ep_on	0	0	No	No	Yes	Yes	8	5
429	8x55	8x59	ep_on	0	0	No	No	No	No	4	4
430	4x55	4x59	ep_on	0	0	No	No	Yes	No	4	8

Orange: nodes, hubs and links specific of ep_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of ep_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	ep_off Avg Int. Strength	ep_on Avg Int. Strength	ep_off Num Of Links	ep_on Num Of Links	ConSurf
1	1x39	ep_off	100	33.3333	4	2	7
2	1x54	ep_off	0	0	4	2	8
3	2x39	ep_off	100	0	4	3	8
4	E1x50	ep_off	100	0	5	3	6
5	E1x51	ep_off	0	0	4	2	4
6	3x33	ep_off	100	25	4	1	7
7	3x37	ep_off	50	0	4	2	8
8	3x39	ep_off	100	0	4	1	9
9	3x50	ep_off	100	22.2222	5	2	9
10	4x38	ep_off	100	0	5	2	8
11	4x59	ep_off	0	0	4	2	8
12	5x51	ep_off	0	0	4	2	7
13	6x38	ep_off	0	0	4	1	7
14	6x58	ep_off	100	33.3333	4	2	6
15	6x59	ep_off	50	0	4	3	6
16	7x34	ep_off	100	0	4	3	6
17	7x35	ep_off	100	16.6667	4	3	6
18	I1	Shared	100	16.6667	8	4	6
19	3x34	Shared	100	33.3333	4	5	7
20	3x35	Shared	100	50	4	4	7
21	3x51	Shared	0	27.7778	4	4	8
22	I2x53	Shared	100	16.6667	5	4	8
23	E2	Shared	100	100	21	22	5
24	E2x51	Shared	100	33.3333	5	4	6
25	5x39	Shared	100	58.3333	4	4	8
26	6x54	Shared	100	16.6667	4	6	6
27	E3	Shared	100	66.6667	4	6	2
28	Lig	Shared	100	100	12	14	0
29	2x46	ep_on	0	33.3333	1	4	9
30	2x50	ep_on	0	30.5556	2	4	9
31	E1	ep_on	0	33.3333	0	5	4
32	3x46	ep_on	0	0	3	4	9
33	4x40	ep_on	0	0	1	4	5
34	4x50	ep_on	0	38.8889	2	7	8
35	5x58	ep_on	0	16.6667	2	4	9
36	5x69	ep_on	0	0	1	4	5
37	5x72	ep_on	0	0	0	4	0
38	6x29	ep_on	0	0	2	4	7
39	6x30	ep_on	0	0	1	5	8
40	6x37	ep_on	0	0	3	4	8
41	6x48	ep_on	0	33.3333	1	4	8
42	7x39	ep_on	0	58.3333	2	6	7
43	7x45	ep_on	50	33.3333	3	5	9
44	7x49	ep_on	0	33.3333	3	5	9
45	7x50	ep_on	0	0	3	4	9
46	7x53	ep_on	0	80.5555	3	5	9
47	7x55	ep_on	0	0	0	4	6

Orange: nodes, hubs and links specific of ep_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of ep_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	ep_off Recurrence	ep_on Recurrence	ep_off Hub1?	ep_on Hub1?	ep_off Hub2?	ep_on Hub2?	ConSurf1	ConSurf2
1	2x64	Lig	ep_off	11.8645	5.702	No	No	Yes	Yes	6	0
2	1x42	Lig	ep_off	11.8645	5.17184	No	No	Yes	Yes	8	0
3	1x42	7x47	ep_off	10.2127	0	No	No	No	No	8	8
4	5x39	E2	ep_off	74.3702	8.13035	Yes	Yes	Yes	Yes	8	5
5	5x39	5x42	ep_off	78.1868	0	Yes	Yes	No	No	8	5
6	4x56	5x42	ep_off	78.6921	3.9521	No	No	No	No	7	5
7	4x56	5x46	ep_off	70.3349	0	No	No	No	No	7	6
8	5x46	5x50	ep_off	99.3212	1.72765	No	No	No	No	6	8
9	3x40	5x50	ep_off	99.7737	3.4516	No	No	No	No	8	8
10	3x40	5x51	ep_off	100	0	No	No	Yes	No	8	7
11	5x51	6x49	ep_off	27.6889	0	Yes	No	No	No	7	7
12	6x49	6x50	ep_off	26.1804	3.89649	No	No	No	No	7	9
13	6x50	7x40	ep_off	24.6568	1.9501	No	No	No	No	9	8
14	6x47	7x40	ep_off	23.1181	0	No	No	No	No	9	8
15	3x39	7x45	ep_off	15.0626	0	Yes	No	No	Yes	9	9
16	3x39	7x46	ep_off	11.8721	1.31613	Yes	No	No	No	9	9
17	2x54	7x46	ep_off	10.2202	0	No	No	No	No	8	9
18	5x51	6x45	ep_off	98.944	0	Yes	No	No	No	7	6
19	5x54	6x45	ep_off	98.7328	0	No	No	No	No	8	6
20	5x54	6x41	ep_off	95.4141	0	No	No	No	No	8	8
21	3x43	6x41	ep_off	39.4328	0	No	No	No	No	8	8
22	3x43	3x46	ep_off	38.2712	0	No	No	No	Yes	8	9
23	2x43	3x46	ep_off	50.1056	0	No	No	No	Yes	8	9
24	2x43	2x47	ep_off	29.1824	0	No	No	No	No	8	8
25	1x50	2x47	ep_off	19.8748	0	No	No	No	No	9	8
26	1x50	7x50	ep_off	16.8125	0.975049	No	No	No	Yes	9	9
27	2x43	7x53	ep_off	23.8648	0	No	No	No	Yes	8	9
28	6x36	7x53	ep_off	14.6327	0	No	No	No	Yes	8	9
29	6x37	6x41	ep_off	55.9134	0	No	Yes	No	No	8	8
30	2x39	6x37	ep_off	50.0905	0	Yes	No	No	Yes	8	8
31	2x39	6x33	ep_off	15.1003	0	Yes	No	No	No	8	9
32	6x33	I1	ep_off	14.7156	0	No	No	Yes	Yes	9	6
33	2x39	3x50	ep_off	42.5856	0	Yes	No	Yes	No	8	9
34	3x50	I2x53	ep_off	13.7804	0	Yes	No	Yes	Yes	9	8
35	3x50	4x38	ep_off	14.3762	0	Yes	No	Yes	No	9	8
36	3x49	3x50	ep_off	15.9225	0	No	No	Yes	No	9	9
37	2x42	4x46	ep_off	14.1424	0	No	No	No	No	8	8
38	3x33	E2x51	ep_off	20.6819	2.00942	Yes	No	Yes	Yes	7	6
39	3x33	5x43	ep_off	25.5242	0	Yes	No	No	No	7	7
40	3x37	5x43	ep_off	26.3237	2.30601	Yes	No	No	No	8	7
41	3x37	4x53	ep_off	34.9072	3.61102	Yes	No	No	No	8	8
42	3x38	4x53	ep_off	30.3967	0	No	No	No	No	8	8
43	3x34	3x38	ep_off	28.1189	0	Yes	Yes	No	No	7	8
44	E2	E2x51	ep_off	14.0066	4.47484	Yes	Yes	Yes	Yes	5	6
45	E1x50	E2	ep_off	17.4612	6.42494	Yes	No	Yes	Yes	6	5
46	3x47	5x54	ep_off	16.8125	0	No	No	No	No	9	8
47	3x47	5x57	ep_off	15.1984	3.89649	No	No	No	No	9	7
48	3x51	5x57	ep_off	11.9249	0	Yes	Yes	No	No	8	7
49	I2x53	I2x57	ep_off	10.9217	7.96352	Yes	Yes	No	No	8	7
50	4x41	I2x57	ep_off	18.7736	0	No	No	No	No	5	7
51	4x41	I2x56	ep_off	15.6811	0	No	No	No	No	5	5
52	4x38	I2x57	ep_off	10.9217	0	Yes	No	No	No	8	7
53	6x55	E2	ep_off	14.4366	0	No	No	Yes	Yes	7	5
54	5x44	6x55	ep_off	12.8752	0	No	No	No	No	7	7
55	5x44	6x56	ep_off	11.0801	1.32355	No	No	No	No	7	6
56	5x58	6x38	ep_off	15.1757	0	No	Yes	Yes	No	9	7
57	3x37	5x46	ep_off	28.7977	0	Yes	No	No	No	8	6
58	E2	Lig	Shared	34.1831	57.3499	Yes	Yes	Yes	Yes	5	0
59	6x47	7x45	Shared	19.9955	11.9601	No	No	No	Yes	9	9
60	2x42	3x49	Shared	15.7339	48.3965	No	No	No	No	8	9
61	3x34	3x35	Shared	16.5032	29.3034	Yes	Yes	Yes	Yes	7	7
62	5x58	6x37	Shared	16.7069	36.5884	No	Yes	No	Yes	9	8
63	2x39	3x46	Shared	14.2933	11.8415	Yes	No	No	Yes	8	9
64	7x46	Lig	ep_on	0	99.062	No	No	Yes	Yes	9	0
65	2x50	7x46	ep_on	0	100	No	Yes	No	No	9	9
66	2x50	7x50	ep_on	0	31.9542	No	Yes	No	Yes	9	9
67	7x49	7x50	ep_on	0	32.8884	No	Yes	No	Yes	9	9
68	7x45	7x49	ep_on	3.34138	49.6719	No	Yes	No	Yes	9	9
69	2x46	2x50	ep_on	0	70.793	No	Yes	No	Yes	9	9
70	2x46	7x49	ep_on	0	37.7377	No	Yes	No	Yes	9	9
71	2x46	3x46	ep_on	0	52.7083	No	Yes	No	Yes	9	9
72	2x42	3x46	ep_on	0	49.2455	No	No	No	Yes	8	9
73	3x49	I2x53	ep_on	0	45.7272	No	No	Yes	Yes	9	8
74	2x56	Lig	ep_on	0	38.6386	No	No	Yes	Yes	7	0
75	2x56	3x31	ep_on	0	35.6987	No	No	No	No	7	5
76	3x31	3x35	ep_on	6.90149	32.7068	No	No	Yes	Yes	5	7
77	3x34	4x50	ep_on	4.89516	20.2239	Yes	Yes	No	Yes	7	8
78	4x46	4x50	ep_on	0	11.6079	No	No	No	Yes	8	8
79	2x45	4x46	ep_on	0	10.3474	No	No	No	No	8	8
80	6x48	7x45	ep_on	0	24.6395	No	Yes	No	Yes	8	9
81	5x51	6x48	ep_on	0	14.7629	Yes	No	No	Yes	7	8
82	5x51	6x52	ep_on	0	13.0909	Yes	No	No	No	7	7
83	7x49	7x53	ep_on	0	38.1233	No	Yes	No	Yes	9	9
84	3x46	7x53	ep_on	0	28.6694	No	Yes	No	Yes	9	9
85	6x40	7x53	ep_on	8.57595	43.703	No	No	No	Yes	8	9
86	3x50	6x40	ep_on	0	42.2089	Yes	No	No	No	9	8
87	3x50	6x37	ep_on	0	40.9335	Yes	No	No	Yes	9	8
88	3x51	5x58	ep_on	0	24.2798	Yes	Yes	No	Yes	8	9
89	3x53	I2x53	ep_on	1.77251	39.8287	No	No	Yes	Yes	9	8
90	3x53	3x54	ep_on	0	38.9946	No	No	No	No	9	9
91	3x54	5x61	ep_on	5.19686	37.4263	No	No	No	No	9	9
92	5x61	5x65	ep_on	0	36.7886	No	No	No	No	9	9
93	5x65	6x30	ep_on	0	14.3254	No	No	No	Yes	9	8
94	5x65	6x33	ep_on	0	23.4753	No	No	No	No	9	9
95	6x33	8x48	ep_on	0	13.9287	No	No	No	No	9	6
96	8x48	8x49	ep_on	0	13.1279	No	No	No	No	6	7
97	6x44	7x45	ep_on	0	10.2732	No	No	No	Yes	8	9

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
1x36	2x64	Shared	3.79	5.8375	0	0	2	1
1x38	1x39	ep_off	3.39	0	1	0	1	1
1x38	Lig	ep_off	3.91	0	1	0	1	0
1x39	2x60	ep_off	3.5	0	1	0	1	1
1x39	2x61	Shared	4.235	1.86	1	0	1	2
1x39	Lig	Shared	3.375	6.88389	1	0	1	0
1x42	7x47	ep_off	4.37	0	0	1	1	2
1x43	2x57	Shared	15.85	11.8086	0	0	2	1
2x50	3x39	ep_off	20.25	0	3	2	2	2
2x54	2x57	ep_off	3.2	0	0	0	1	1
2x54	7x46	ep_off	5.25	0	0	0	1	1
2x57	2x58	Shared	5.34	2.99611	0	0	1	2
2x60	Lig	Shared	10.61	5.55694	1	1	1	0
2x64	Lig	Shared	12.855	3.41028	0	1	1	0
E1x50	E2	Shared	3.42	4.77833	1	1	2	1
E1x50	E2x50	ep_off	7.84	0	1	1	2	2
3x25	E2	ep_off	6.89	0	1	0	2	1
3x25	E2x50	Shared	7.28	7.28	1	0	2	2
3x26	E2	Shared	5.75	3.67694	1	1	2	1
3x29	E2	Shared	6.4	8.04389	0	0	2	1
3x32	E2x51	Shared	6.09	5.19972	0	0	1	2
3x32	Lig	Shared	4.74	8.65861	0	0	1	0
3x39	7x46	Shared	10.09	3.24222	3	0	2	1
4x59	4x60	ep_off	3.28	0	1	1	2	2
4x59	E2	Shared	11.07	3.97361	1	1	2	1
4x59	5x39	ep_off	5.86	0	1	1	2	2
4x60	E2	Shared	4.06	10.1906	1	1	2	1
4x60	5x39	Shared	10.435	5.40417	1	1	2	2
5x39	E2	Shared	6.865	3.95667	1	1	2	1
5x36	E2	Shared	18.62	7.74917	1	1	2	1
E2	E2x50	Shared	8.2	2.98556	1	1	1	2
E2	E2	Shared	121	84.9725	1	1	1	1
E2	E2x51	Shared	18.125	9.50667	1	1	1	2
E2	E3	Shared	15.565	17.2397	1	1	1	2
E2	Lig	Shared	10.835	10.1728	1	1	1	0
7x34	E2	Shared	10.05	9.73972	1	1	2	1
7x35	E2	Shared	5.69	15.3467	1	1	1	1
7x38	E2	Shared	13.505	5.7625	1	0	1	1
6x55	E2	ep_off	4.29	0	1	0	2	1
6x58	E2	Shared	25.99	4.04917	1	1	2	1
6x59	E2	ep_off	3.225	0	1	0	2	1
5x33	E2	ep_off	4.76	0	1	0	2	1
5x33	5x36	Shared	4.845	4.2675	1	0	2	2
6x58	E3	ep_off	5.705	0	1	1	2	2
6x58	7x34	ep_off	12.12	0	1	1	2	2
E3	E3	Shared	26.175	22.7583	1	1	2	2
7x32	7x35	ep_off	13.045	0	0	0	2	1
7x35	7x39	Shared	4.25	9.11111	1	1	1	1
7x35	Lig	Shared	4.74	4.17195	1	1	1	0
7x38	Lig	ep_off	10.745	0	1	0	1	0
7x39	Lig	Shared	38.685	7.89972	1	1	1	0
7x42	Lig	Shared	12.85	13.8122	0	0	1	0
7x43	Lig	ep_off	3.06	0	0	0	1	0
2x56	3x32	ep_off	2.98	0	0	0	1	1
1x35	2x64	ep_off	2.78	0	0	0	2	1
3x36	5x43	ep_off	2.54	0	0	0	1	2
3x28	E1x50	ep_off	2.47	0	0	0	2	2
1x42	Lig	Shared	1.94	6.77583	0	1	1	0
4x59	4x63	ep_off	1.71	0	1	1	2	2
5x33	5x35	ep_off	1.7	0	1	0	2	2
1x38	7x39	ep_on	0	5.39389	1	0	1	1
1x42	7x39	ep_on	0	3.68556	0	1	1	1
2x50	7x46	ep_on	0	7.6175	3	2	2	1
2x54	Lig	ep_on	0	11.2394	0	0	1	0
2x56	3x31	ep_on	0	4.445	0	0	1	2
2x56	Lig	ep_on	0	5.19889	0	0	1	0
2x57	Lig	ep_on	0	6.67694	0	0	1	0
2x64	E2	ep_on	0	8.91389	0	1	1	1
3x36	Lig	ep_on	0	3.32611	0	0	1	0
7x32	E3	ep_on	0	3.6075	0	0	2	2
7x46	Lig	ep_on	0	4.46528	0	0	1	0
2x56	3x28	ep_on	0	4.12389	0	0	1	2
2x60	E2	ep_on	0	3.17333	1	1	1	1
7x34	E3	ep_on	0	3.71556	1	1	2	2
6x47	7x43	ep_on	0	2.76028	0	0	2	1
7x43	7x47	ep_on	0	2.61417	0	0	1	2
E1x49	E2	ep_on	0	2.4875	0	1	2	1
1x35	1x36	ep_on	0	1.58222	0	0	2	2
5x35	E2	ep_on	0	1.5175	0	0	2	1
7x36	7x39	ep_on	0	1.42778	0	0	2	1
1x41	1x42	ep_on	0	1.13	0	0	2	1
5x43	6x55	ep_on	0	1.04	0	0	2	2
7x39	NT	ep_on	0	0.516667	1	1	1	2
4x63	E2	ep_on	0	0.285	0	0	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	ep_off	ep4_off
	ep_on	ep4_on ep2_on ep3_on

Network Difference
Value	ep_off	ep_on
I_min	3.075	2.99417
Number of Linked Nodes	226	260
Number of Specific Nodes	1 (0.44%)	35 (13.46%)
Number of Shared Nodes	225 (99.56%)	225 (86.54%)
Number of Links	257	279
Number of Specific Links	151 (58.75%)	173 (62.01%)
Number of Shared Links	106 (41.25%)	106 (37.99%)
Number of Hubs	28	30
Number of Specific Hubs	17 (60.71%)	19 (63.33%)
Number of Shared Hubs	11 (39.29%)	11 (36.67%)
Average % Shared Neighbours (Jaccard)	25.31
Average % Shared Neighbours (Otsuka)	33.16
Average % Shared Neighbours (Overlap Coefficient)	40.33
Average % Shared Cliques (k3-6)	52.34
Graphlets Similarity	0.509059

Paths Difference
Value	ep_off	ep_on
Number Of Nodes in MetaPath	61	39
Specific Nodes in MetaPath	40 (65.57%)	18 (46.15%)
Shared Nodes in MetaPath	225 (99.56%)	225 (99.56%)
Number Of Links MetaPath	63	40
Specific Links in MetaPath	57 (90.48%)	34 (85.00%)
Shared Links in MetaPath	106 (41.25%)	106 (41.25%)
Number of Shortest Paths	27740	46329
Length Of Smallest Path	3	3
Average Path Length	13.5544	13.1766
Length of Longest Path	27	31
Minimum Path Strength	1.395	0.597917
Average Path Strength	6.58788	4.40717
Maximum Path Strength	25.77	13.7416
Minimum Path Correlation	0.7	0.700833
Average Path Correlation	0.916982	0.90055
Maximum Path Correlation	0.99	0.984167
Minimum % Of Corr. Nodes	4.16667	3.57143
Average % Of Corr. Nodes	45.4158	39.2748
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	29.3075	45.1409
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download ep_off_on.zip<

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