psnGPCR

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Orange: nodes, hubs and links specific of etb_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of etb_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	etb_off Int. Strength	etb_on Int. Strength	etb_off Hub1?	etb_on Hub1?	etb_off Hub2?	etb_on Hub2?	ConSurf1	ConSurf2
1	2x53	Lig	etb_off	100	0	Yes	No	Yes	Yes	8	0
2	3x29	Lig	etb_off	100	0	Yes	No	Yes	Yes	5	0
3	3x36	Lig	etb_off	100	0	No	No	Yes	Yes	7	0
4	4x65	Lig	etb_off	100	0	Yes	No	Yes	Yes	5	0
5	7x38	Lig	etb_off	100	0	No	No	Yes	Yes	6	0
6	1x24	7x27	etb_off	100	0	No	No	No	No	4	3
7	1x27	7x32	etb_off	100	0	No	No	No	No	5	1
8	1x28	7x35	etb_off	100	0	No	No	Yes	Yes	3	3
9	1x31	1x34	etb_off	100	0	Yes	No	No	No	4	5
10	1x31	1x35	etb_off	100	0	Yes	No	Yes	No	4	5
11	1x31	7x35	etb_off	100	0	Yes	No	Yes	Yes	4	3
12	1x32	E1.E165	etb_off	100	0	Yes	No	No	No	6	4
13	1x36	2x65	etb_off	100	0	Yes	No	No	No	6	4
14	1x42	7x47	etb_off	100	0	No	No	No	No	8	8
15	1x50	2x47	etb_off	100	0	Yes	Yes	No	No	9	9
16	1x53	2x43	etb_off	100	0	Yes	No	No	No	9	8
17	1x53	7x50	etb_off	100	0	Yes	No	No	No	9	9
18	1x54	2x48	etb_off	100	0	No	No	No	No	7	6
19	1x55	1x59	etb_off	100	0	No	No	No	No	3	4
20	1x58	1x59	etb_off	100	0	No	No	No	No	2	4
21	8x49	I1x50	etb_off	100	0	No	No	Yes	Yes	6	7
22	8x50	I1x50	etb_off	100	0	Yes	Yes	Yes	Yes	9	7
23	2x39	3x50	etb_off	100	0	No	No	Yes	No	8	9
24	2x40	3x50	etb_off	100	0	Yes	No	Yes	No	8	9
25	2x40	8x50	etb_off	100	0	Yes	No	Yes	Yes	8	9
26	2x45	4x50	etb_off	100	0	No	No	No	No	9	9
27	2x46	3x39	etb_off	100	0	Yes	Yes	No	No	9	9
28	2x53	2x57	etb_off	100	0	Yes	No	Yes	No	8	7
29	2x53	3x32	etb_off	100	0	Yes	No	No	No	8	6
30	2x53	7x46	etb_off	100	0	Yes	No	No	No	8	9
31	2x54	7x46	etb_off	100	0	No	No	No	No	6	9
32	2x59	E1x52	etb_off	100	0	No	No	Yes	No	6	7
33	2x59	3x28	etb_off	100	0	No	No	No	No	6	5
34	E1x50	E1x51	etb_off	100	0	Yes	Yes	No	No	9	2
35	E1x50	E1x52	etb_off	100	0	Yes	Yes	Yes	No	9	7
36	E1x50	E2.I242	etb_off	100	0	Yes	Yes	No	No	9	5
37	E1x51	E1x52	etb_off	100	0	No	No	Yes	No	2	7
38	3x33	5x43	etb_off	100	0	Yes	Yes	No	Yes	4	6
39	3x40	6x44	etb_off	100	0	No	No	Yes	No	8	9
40	3x41	4x53	etb_off	100	0	No	No	No	No	6	8
41	3x42	4x49	etb_off	100	0	No	No	No	No	8	7
42	3x46	6x37	etb_off	100	0	No	No	No	No	9	8
43	3x48	3x52	etb_off	100	0	No	No	No	No	6	5
44	3x49	3x52	etb_off	100	0	No	No	No	No	8	5
45	3x49	4x45	etb_off	100	0	No	No	No	No	8	6
46	3x50	6x33	etb_off	100	0	Yes	No	No	No	9	8
47	3x50	6x37	etb_off	100	0	Yes	No	No	No	9	8
48	5x68	I2x50	etb_off	100	0	No	No	No	No	5	8
49	6x26	I2x50	etb_off	100	0	Yes	No	No	No	4	8
50	4x38	4x39	etb_off	100	0	No	No	No	No	6	1
51	4x64	E2.Q261	etb_off	100	0	No	No	No	Yes	5	2
52	E2.I242	E2x50	etb_off	100	0	No	No	No	No	5	9
53	E2.I243	E2x51	etb_off	100	0	No	No	No	No	1	4
54	E2.D246	E2.Y251	etb_off	100	0	No	No	No	No	1	5
55	5x41	6x56	etb_off	100	0	No	No	No	No	5	6
56	5x41	6x59	etb_off	100	0	No	No	No	No	5	5
57	5x42	5x461	etb_off	100	0	Yes	Yes	No	Yes	4	6
58	5x44	6x56	etb_off	100	0	Yes	Yes	No	No	6	6
59	5x58	5x62	etb_off	100	0	Yes	Yes	No	No	9	5
60	5x64	5x68	etb_off	100	0	Yes	No	No	No	5	5
61	6x24	6x26	etb_off	100	0	No	No	Yes	No	2	4
62	6x24	6x27	etb_off	100	0	No	No	No	No	2	4
63	6x26	6x30	etb_off	100	0	Yes	No	No	No	4	7
64	6x32	8x47	etb_off	100	0	No	No	No	No	7	8
65	6x35	7x56	etb_off	100	0	No	No	No	No	5	7
66	6x36	8x47	etb_off	100	0	No	No	No	No	8	8
67	6x39	7x56	etb_off	100	0	No	No	No	No	5	7
68	6x40	7x53	etb_off	100	0	No	No	No	No	8	9
69	6x51	6x55	etb_off	100	0	No	No	No	No	6	6
70	6x51	7x37	etb_off	100	0	No	No	No	No	6	7
71	6x55	7x34	etb_off	100	0	No	No	No	No	6	4
72	6x62	E3.Q352	etb_off	100	0	Yes	No	No	No	2	1
73	8x51	8x55	etb_off	100	0	No	No	No	No	8	4
74	3x52	4x41	etb_off	100	0	No	No	Yes	Yes	5	5
75	6x32	8x48	etb_off	100	0	No	No	No	No	7	5
76	8x51	8x52	etb_off	100	0	No	No	No	No	8	4
77	5x64	I2x54	etb_off	100	0	Yes	No	Yes	No	5	4
78	6x28	8x48	etb_off	66.6667	0	No	No	No	No	4	5
79	6x29	6x33	etb_off	66.6667	0	No	No	No	No	5	8
80	1x53	1x57	etb_off	33.3333	0	Yes	No	No	No	9	7
81	6x31	6x35	etb_off	33.3333	0	No	No	No	No	5	5
82	I2x52	I2x54	etb_off	33.3333	0	No	No	Yes	No	5	4
83	3x24	3x27	etb_off	33.3333	0	No	No	No	No	6	5
84	1x22	1x23	etb_off	33.3333	0	No	No	No	No	4	4
85	6x49	6x50	etb_off	33.3333	0	No	No	No	No	5	9
86	2x56	3x31	etb_off	33.3333	0	No	Yes	No	Yes	6	5
87	7x23	7x24	etb_off	33.3333	0	Yes	Yes	No	No	5	8
88	3x43	6x44	etb_off	66.6667	0	No	No	Yes	No	8	9
89	5x32	5x35	etb_off	33.3333	0	Yes	Yes	Yes	Yes	4	3
90	6x58	6x62	etb_off	33.3333	0	No	No	Yes	No	4	2
91	7x45	7x49	etb_off	33.3333	0	Yes	No	Yes	Yes	9	9
92	1x60	I1x49	etb_off	66.6667	0	No	No	No	No	6	5
93	6x62	7x26	etb_off	33.3333	0	Yes	No	No	No	2	2
94	1x27	7x28	etb_off	33.3333	0	No	No	No	No	5	3
95	3x45	4x45	etb_off	33.3333	0	No	No	No	No	7	6
96	7x36	7x40	etb_off	0	0	No	No	No	No	5	7
97	E2.I254	E2.M245	etb_off	33.3333	0	No	No	No	No	4	1
98	7x29	7x30	etb_off	66.6667	0	No	No	No	No	3	3
99	E2.M245	NT.P88	etb_off	33.3333	0	No	No	Yes	No	1	7
100	1x41	1x45	etb_off	33.3333	0	No	No	No	No	4	5
101	2x60	2x64	etb_off	33.3333	0	No	Yes	No	Yes	7	4
102	E3.N351	E3.N356	etb_off	33.3333	0	No	No	No	No	1	3
103	E1x49	E2.L252	etb_off	33.3333	0	No	No	No	No	5	3
104	3x55	I2x50	etb_off	33.3333	0	No	No	No	No	7	8
105	2x41	4x42	etb_off	33.3333	0	No	No	No	No	6	7
106	5x53	5x57	etb_off	0	0	No	No	Yes	Yes	7	7
107	1x51	2x51	etb_off	33.3333	0	No	No	No	No	4	7
108	5x31	5x32	etb_off	66.6667	0	No	No	Yes	Yes	3	4
109	3x56	5x64	etb_off	33.3333	0	No	No	Yes	No	7	5
110	1x26	1x30	etb_off	33.3333	0	No	No	No	No	5	5
111	6x27	I3.L311	etb_off	33.3333	0	No	No	No	No	4	4
112	5x65	6x34	etb_off	33.3333	0	Yes	Yes	No	No	8	7
113	7x42	Lig	etb_off	33.3333	0	No	No	Yes	Yes	7	0
114	I1x51	I1x52	etb_off	33.3333	0	No	No	No	No	7	8
115	6x43	7x49	etb_off	0	0	No	No	Yes	Yes	6	9
116	2x41	4x46	etb_off	0	0	No	No	No	No	6	7
117	1x54	1x58	etb_off	33.3333	0	No	No	No	No	7	2
118	E2.I254	E2.L252	etb_off	33.3333	0	No	No	No	No	4	3
119	3x53	I2x52	etb_off	33.3333	0	No	No	No	No	8	5
120	6x39	7x52	etb_off	0	0	No	No	No	No	5	7
121	5x58	6x34	etb_off	0	0	Yes	Yes	No	No	9	7
122	1x36	1x40	etb_off	0	0	Yes	No	No	No	6	4
123	6x38	6x42	etb_off	0	0	No	No	No	No	5	5
124	1x56	8x57	etb_off	0	0	No	No	No	No	7	6
125	5x41	6x60	etb_off	0	0	No	No	No	No	5	4
126	4x51	4x55	etb_off	0	0	No	No	No	No	4	4
127	7x23	E3.D354	etb_off	33.3333	0	Yes	Yes	No	Yes	5	1
128	5x36	E2x52	etb_off	0	0	No	No	No	No	4	5
129	7x54	7x55	etb_off	0	0	Yes	No	No	No	7	6
130	3x22	E2.D241	etb_off	0	0	No	No	No	No	3	4
131	1x47	2x55	etb_off	0	0	No	No	No	No	7	5
132	2x55	2x551	etb_off	0	0	No	No	No	No	5	5
133	8x52	8x56	etb_off	33.3333	0	No	No	No	No	4	5
134	1x36	2x64	etb_off	33.3333	0	Yes	No	No	Yes	6	4
135	1x32	2x65	etb_off	33.3333	0	Yes	No	No	No	6	4
136	3x21	E1x50	etb_off	0	0	No	No	Yes	Yes	8	9
137	E2.Y247	NT.P88	etb_off	33.3333	0	No	No	Yes	No	2	7
138	7x27	7x31	etb_off	0	0	No	No	No	No	3	3
139	1x22	1x25	etb_off	0	0	No	No	No	No	4	4
140	1x25	1x26	etb_off	33.3333	0	No	No	No	No	4	5
141	I2x53	I2x57	etb_off	33.3333	0	No	No	No	No	6	6
142	I2x54	I2x55	etb_off	0	0	Yes	No	No	No	4	3
143	3x53	I2x51	etb_off	0	0	No	No	No	No	8	5
144	3x21	3x23	etb_off	0	0	No	No	No	No	8	1
145	8x55	8x59	etb_off	0	0	No	No	No	No	4	5
146	4x44	4x48	etb_off	0	0	No	No	No	No	3	3
147	5x33	5x37	etb_off	0	0	No	No	No	No	1	4
148	5x58	5x59	etb_off	0	0	Yes	Yes	No	No	9	4
149	4x41	I2x53	etb_off	0	0	Yes	Yes	No	No	5	6
150	NT.P87	NT.P88	etb_off	0	0	No	No	Yes	No	7	7
151	NT.P87	NT.S86	etb_off	0	0	No	No	No	No	7	5
152	I2x55	I2x56	etb_off	0	0	No	No	No	No	3	3
153	4x38	4x43	etb_off	0	0	No	No	No	No	6	3
154	5x62	5x63	etb_off	0	0	No	No	No	No	5	4
155	E3.N353	E3.P355	etb_off	0	0	No	No	No	No	1	1
156	E3.N356	E3.P355	etb_off	0	0	No	No	No	No	3	1
157	E2.Y251	NT.I85	etb_off	0	0	No	No	No	No	5	4
158	5x64	5x67	etb_off	0	0	Yes	No	No	No	5	4
159	2x60	Lig	Shared	100	100	No	Yes	Yes	Yes	7	0
160	2x63	Lig	Shared	100	100	No	No	Yes	Yes	5	0
161	3x32	Lig	Shared	100	100	No	No	Yes	Yes	6	0
162	3x33	Lig	Shared	100	100	Yes	Yes	Yes	Yes	4	0
163	5x43	Lig	Shared	100	100	No	Yes	Yes	Yes	6	0
164	6x48	Lig	Shared	100	100	Yes	Yes	Yes	Yes	8	0
165	6x51	Lig	Shared	100	100	No	No	Yes	Yes	6	0
166	6x52	Lig	Shared	100	100	Yes	Yes	Yes	Yes	8	0
167	6x55	Lig	Shared	100	100	No	No	Yes	Yes	6	0
168	7x24	NT.C90	Shared	100	100	No	No	No	Yes	8	7
169	1x23	1x24	Shared	100	100	No	No	No	No	4	4
170	1x27	7x31	Shared	100	100	No	No	No	No	5	3
171	1x29	1x32	Shared	100	100	No	No	Yes	No	3	6
172	1x31	7x32	Shared	100	100	Yes	No	No	No	4	1
173	1x35	2x64	Shared	100	100	Yes	No	No	Yes	5	4
174	1x35	7x35	Shared	100	100	Yes	No	Yes	Yes	5	3
175	1x35	7x39	Shared	100	100	Yes	No	No	No	5	5
176	1x38	7x39	Shared	100	0	No	No	No	No	5	5
177	1x39	2x61	Shared	100	50	No	No	No	No	7	7
178	1x42	7x42	Shared	100	100	No	No	No	No	8	7
179	1x43	2x57	Shared	100	100	No	Yes	Yes	No	7	7
180	1x43	2x58	Shared	100	100	No	Yes	No	No	7	9
181	1x49	7x50	Shared	100	50	No	No	No	No	8	9
182	1x50	2x50	Shared	100	100	Yes	Yes	No	Yes	9	9
183	1x50	7x50	Shared	100	50	Yes	Yes	No	No	9	9
184	1x52	8x54	Shared	100	100	No	No	Yes	Yes	6	7
185	1x52	8x58	Shared	100	0	No	No	No	No	6	6
186	1x53	2x47	Shared	100	0	Yes	No	No	No	9	9
187	1x53	7x53	Shared	100	100	Yes	No	No	No	9	9
188	1x53	8x50	Shared	100	100	Yes	No	Yes	Yes	9	9
189	1x56	8x53	Shared	100	100	No	No	No	No	7	4
190	1x56	8x54	Shared	100	100	No	No	Yes	Yes	7	7
191	1x57	2x44	Shared	100	100	No	No	No	No	7	7
192	1x60	I1x50	Shared	100	100	No	No	Yes	Yes	6	7
193	2x40	I1x50	Shared	100	100	Yes	No	Yes	Yes	8	7
194	I1x52	I2x54	Shared	100	0	No	No	Yes	No	8	4
195	2x38	2x39	Shared	100	100	No	No	No	No	7	8
196	2x45	4x46	Shared	100	100	No	No	No	No	9	7
197	2x46	3x42	Shared	100	100	Yes	Yes	No	No	9	8
198	2x46	7x49	Shared	100	100	Yes	Yes	Yes	Yes	9	9
199	2x48	4x50	Shared	100	0	No	No	No	No	6	9
200	2x50	3x39	Shared	100	100	No	Yes	No	No	9	9
201	2x53	2x56	Shared	100	100	Yes	No	No	Yes	8	6
202	2x53	3x35	Shared	100	100	Yes	No	No	No	8	8
203	2x551	3x31	Shared	100	100	No	No	No	Yes	5	5
204	2x57	2x58	Shared	100	100	Yes	No	No	No	7	9
205	2x62	E1x52	Shared	100	100	No	No	Yes	No	4	7
206	2x63	E1x50	Shared	100	100	No	No	Yes	Yes	5	9
207	E1x49	E2.R253	Shared	100	100	No	No	No	No	5	5
208	3x25	E1x50	Shared	100	100	No	No	Yes	Yes	9	9
209	E1x50	E2x50	Shared	100	100	Yes	Yes	No	No	9	9
210	3x24	E1x52	Shared	100	100	No	No	Yes	No	6	7
211	3x25	E2x50	Shared	100	100	No	No	No	No	9	9
212	3x26	E2.D241	Shared	100	100	No	No	No	No	7	4
213	3x28	3x29	Shared	100	100	No	No	Yes	No	5	5
214	3x29	4x61	Shared	100	100	Yes	No	Yes	Yes	5	5
215	3x29	4x65	Shared	100	100	Yes	No	Yes	No	5	5
216	3x30	4x54	Shared	100	0	Yes	Yes	No	No	6	3
217	3x30	4x57	Shared	100	100	Yes	Yes	No	No	6	7
218	3x32	3x33	Shared	100	100	No	No	Yes	Yes	6	4
219	3x33	4x61	Shared	100	100	Yes	Yes	Yes	Yes	4	5
220	3x36	5x461	Shared	100	100	No	No	No	Yes	7	6
221	3x36	6x48	Shared	100	100	No	No	Yes	Yes	7	8
222	3x37	4x53	Shared	100	100	No	No	No	No	6	8
223	3x38	4x50	Shared	100	100	No	No	No	No	7	9
224	3x38	4x53	Shared	100	100	No	No	No	No	7	8
225	3x40	5x50	Shared	100	100	No	No	No	No	8	9
226	3x41	4x49	Shared	100	100	No	No	No	No	6	7
227	3x44	5x53	Shared	100	100	No	No	No	No	8	7
228	3x47	5x54	Shared	100	100	No	No	No	No	9	8
229	3x48	5x57	Shared	100	100	No	No	Yes	Yes	6	7
230	3x51	5x57	Shared	100	100	No	Yes	Yes	Yes	8	7
231	3x51	5x60	Shared	100	100	No	Yes	No	No	8	3
232	3x54	5x61	Shared	100	100	No	No	No	No	9	8
233	3x54	5x65	Shared	100	100	No	No	Yes	Yes	9	8
234	4x39	4x42	Shared	100	100	No	No	No	No	1	7
235	4x41	4x44	Shared	100	50	Yes	Yes	No	No	5	3
236	4x52	4x56	Shared	100	0	No	No	No	Yes	4	5
237	4x56	5x42	Shared	100	100	No	Yes	Yes	Yes	5	4
238	4x56	5x46	Shared	100	100	No	Yes	Yes	Yes	5	5
239	4x59	4x60	Shared	100	100	No	No	No	No	4	8
240	4x60	5x35	Shared	100	100	No	No	Yes	Yes	8	3
241	4x61	4x65	Shared	100	100	Yes	Yes	Yes	No	5	5
242	4x61	5x35	Shared	100	100	Yes	Yes	Yes	Yes	5	3
243	4x61	5x39	Shared	100	100	Yes	Yes	No	No	5	7
244	4x63	5x32	Shared	100	0	No	No	Yes	Yes	5	4
245	4x65	E2x52	Shared	100	100	Yes	No	No	No	5	5
246	E2.D241	E2.H258	Shared	100	100	No	No	Yes	Yes	4	4
247	E2.K248	E2.Y247	Shared	100	100	No	No	No	No	1	2
248	E2.H258	E2.P259	Shared	100	100	Yes	Yes	No	No	4	6
249	E2.H258	E2.V260	Shared	100	100	Yes	Yes	No	No	4	3
250	5x32	E2.Q261	Shared	100	100	Yes	Yes	No	Yes	4	2
251	5x33	E2.Q261	Shared	100	0	No	No	No	Yes	1	2
252	5x29	E2.K262	Shared	100	0	No	No	No	No	3	1
253	5x35	5x39	Shared	100	100	Yes	Yes	No	No	3	7
254	5x35	5x42	Shared	100	100	Yes	Yes	Yes	Yes	3	4
255	5x39	5x43	Shared	100	100	No	No	No	Yes	7	6
256	5x40	6x59	Shared	100	100	No	Yes	No	No	5	5
257	5x42	5x46	Shared	100	100	Yes	Yes	Yes	Yes	4	5
258	5x44	5x47	Shared	100	100	Yes	Yes	Yes	Yes	6	8
259	5x44	5x48	Shared	100	100	Yes	Yes	No	No	6	5
260	5x44	6x52	Shared	100	100	Yes	Yes	Yes	Yes	6	8
261	5x46	5x461	Shared	100	100	Yes	Yes	No	Yes	5	6
262	5x46	5x49	Shared	100	100	Yes	Yes	No	No	5	6
263	5x47	5x51	Shared	100	50	Yes	Yes	No	No	8	7
264	5x47	6x49	Shared	100	100	Yes	Yes	No	No	8	5
265	5x47	6x52	Shared	100	100	Yes	Yes	Yes	Yes	8	8
266	5x54	6x41	Shared	100	50	No	No	No	No	8	8
267	5x56	5x57	Shared	100	100	No	No	Yes	Yes	4	7
268	5x56	5x60	Shared	100	100	No	No	No	No	4	3
269	5x58	6x38	Shared	100	0	Yes	Yes	No	No	9	5
270	5x61	5x65	Shared	100	100	No	No	Yes	Yes	8	8
271	5x65	6x30	Shared	100	100	Yes	Yes	No	No	8	7
272	5x68	6x30	Shared	100	50	No	No	No	No	5	7
273	6x40	7x49	Shared	100	0	No	No	Yes	Yes	8	9
274	6x42	6x46	Shared	100	100	No	No	No	No	5	5
275	6x44	6x48	Shared	100	100	Yes	No	Yes	Yes	9	8
276	6x44	7x45	Shared	100	100	Yes	No	Yes	No	9	9
277	6x47	7x45	Shared	100	100	No	No	Yes	No	8	9
278	6x48	6x52	Shared	100	100	Yes	Yes	Yes	Yes	8	8
279	6x48	7x41	Shared	100	100	Yes	Yes	No	No	8	8
280	6x48	7x45	Shared	100	100	Yes	Yes	Yes	No	8	9
281	6x50	7x40	Shared	100	100	No	No	No	No	9	7
282	6x53	6x57	Shared	100	50	No	No	No	No	6	5
283	6x54	7x34	Shared	100	100	No	No	No	No	5	4
284	6x60	6x61	Shared	100	0	No	No	No	No	4	3
285	6x62	7x23	Shared	100	100	Yes	No	Yes	Yes	2	5
286	6x62	7x27	Shared	100	100	Yes	No	No	No	2	3
287	7x23	E3.Q352	Shared	100	100	Yes	Yes	No	No	5	1
288	E3.D354	E3.P355	Shared	100	100	No	Yes	No	No	1	1
289	7x25	E3.N356	Shared	100	50	No	No	No	No	4	3
290	7x26	7x30	Shared	100	50	No	No	No	No	2	3
291	7x31	7x35	Shared	100	100	No	No	Yes	Yes	3	3
292	7x53	8x50	Shared	100	100	No	No	Yes	Yes	9	9
293	7x54	8x51	Shared	100	100	Yes	No	No	No	7	8
294	7x54	8x54	Shared	100	100	Yes	No	Yes	Yes	7	7
295	7x54	8x55	Shared	100	50	Yes	No	No	No	7	4
296	8x47	8x50	Shared	100	100	No	No	Yes	Yes	8	9
297	1x43	1x47	Shared	100	100	No	Yes	No	No	7	7
298	2x40	I1x52	Shared	100	100	Yes	No	No	No	8	8
299	2x46	2x50	Shared	100	100	Yes	Yes	No	Yes	9	9
300	2x62	2x66	Shared	100	50	No	No	No	No	4	5
301	2x62	E1x51	Shared	100	100	No	No	No	No	4	2
302	4x41	4x45	Shared	100	100	Yes	Yes	No	No	5	6
303	E3.N351	E3.N353	Shared	100	100	No	No	No	No	1	1
304	5x34	5x38	Shared	66.6667	100	No	No	No	No	1	4
305	3x30	4x62	Shared	66.6667	50	Yes	Yes	No	No	6	4
306	2x42	3x46	Shared	33.3333	100	No	No	No	No	7	9
307	1x50	2x51	Shared	33.3333	100	Yes	Yes	No	No	9	7
308	1x45	7x47	Shared	33.3333	100	No	No	No	No	5	8
309	5x51	6x45	Shared	33.3333	0	No	No	No	No	7	6
310	E2.H258	E2.I243	Shared	66.6667	100	Yes	Yes	No	No	4	1
311	3x47	5x57	Shared	33.3333	100	No	No	Yes	Yes	9	7
312	2x49	3x38	Shared	66.6667	0	No	No	No	No	8	7
313	3x30	3x31	Shared	66.6667	100	Yes	Yes	No	Yes	6	5
314	E2.I254	E2x51	Shared	33.3333	100	No	No	No	No	4	4
315	2x39	3x49	Shared	66.6667	100	No	No	No	No	8	8
316	6x54	7x33	Shared	33.3333	100	No	No	No	No	5	5
317	E2.R253	E2.T244	Shared	66.6667	50	No	No	No	No	5	1
318	1x39	2x57	Shared	33.3333	100	No	No	Yes	No	7	7
319	5x29	5x32	Shared	0	100	No	No	Yes	Yes	3	4
320	2x52	3x35	Shared	33.3333	100	No	No	No	No	7	8
321	1x42	7x43	Shared	0	50	No	No	No	No	8	6
322	I1x48	I1x51	Shared	33.3333	0	No	No	No	No	6	7
323	1x32	1x33	Shared	33.3333	100	Yes	No	No	No	6	3
324	6x57	7x30	Shared	33.3333	100	No	No	No	No	5	3
325	6x36	7x56	Shared	33.3333	100	No	No	No	No	8	7
326	1x46	7x47	Shared	0	50	No	No	No	No	8	8
327	7x51	7x55	Shared	0	0	No	No	No	No	7	6
328	3x34	4x57	Shared	0	0	No	No	No	No	6	7
329	8x50	8x54	Shared	0	100	Yes	Yes	Yes	Yes	9	7
330	1x48	1x49	Shared	0	50	No	No	No	No	5	8
331	6x43	7x48	Shared	0	100	No	No	No	No	6	6
332	E2.I242	E2.R253	Shared	0	100	No	No	No	No	5	5
333	1x44	1x48	Shared	0	0	No	No	No	No	5	5
334	6x49	6x53	Shared	33.3333	100	No	No	No	No	5	6
335	E2.T244	E2.Y251	Shared	33.3333	100	No	No	No	No	1	5
336	E2.D246	E2.G249	Shared	33.3333	0	No	No	No	No	1	3
337	4x47	4x51	Shared	0	0	No	No	No	No	3	4
338	4x48	4x52	Shared	0	0	No	No	No	No	3	4
339	NT.P88	NT.P89	Shared	0	50	Yes	No	No	No	7	3
340	I2x56	I2x57	Shared	0	0	No	No	No	No	3	6
341	5x59	5x63	Shared	0	0	No	No	No	No	4	4
342	1x36	1x37	Shared	0	0	Yes	No	No	No	6	6
343	E2.L252	E2.S250	Shared	0	100	No	No	No	No	3	1
344	5x44	5x45	Shared	0	0	Yes	Yes	No	No	6	4
345	6x25	6x26	Shared	0	100	No	No	Yes	No	3	4
346	Lig	Lig	etb_on	0	100	Yes	Yes	Yes	Yes	0	0
347	6x58	Lig	etb_on	0	100	No	No	Yes	Yes	4	0
348	E2.M245	Lig	etb_on	0	100	No	No	Yes	Yes	1	0
349	E3.Q352	Lig	etb_on	0	100	No	No	Yes	Yes	1	0
350	6x62	Lig	etb_on	0	100	Yes	No	Yes	Yes	2	0
351	7x23	Lig	etb_on	0	100	Yes	Yes	Yes	Yes	5	0
352	E2.Y247	Lig	etb_on	0	100	No	No	Yes	Yes	2	0
353	7x27	Lig	etb_on	0	100	No	No	Yes	Yes	3	0
354	E2.I254	Lig	etb_on	0	100	No	No	Yes	Yes	4	0
355	1x25	Lig	etb_on	0	100	No	No	Yes	Yes	4	0
356	E2.L252	Lig	etb_on	0	100	No	No	Yes	Yes	3	0
357	7x31	Lig	etb_on	0	100	No	No	Yes	Yes	3	0
358	7x34	Lig	etb_on	0	100	No	No	Yes	Yes	4	0
359	E2x51	Lig	etb_on	0	100	No	No	Yes	Yes	4	0
360	E1.E165	Lig	etb_on	0	100	No	No	Yes	Yes	4	0
361	7x35	Lig	etb_on	0	100	Yes	Yes	Yes	Yes	3	0
362	2x59	Lig	etb_on	0	100	No	No	Yes	Yes	6	0
363	E1x50	Lig	etb_on	0	100	Yes	Yes	Yes	Yes	9	0
364	7x23	NT.C90	etb_on	0	100	Yes	Yes	No	Yes	5	7
365	1x25	7x24	etb_on	0	100	No	No	No	No	4	8
366	1x27	2x64	etb_on	0	100	No	No	No	Yes	5	4
367	1x29	1x33	etb_on	0	100	No	No	No	No	3	3
368	1x32	2x64	etb_on	0	100	Yes	No	No	Yes	6	4
369	1x39	7x39	etb_on	0	100	No	No	No	No	7	5
370	8x53	I1x50	etb_on	0	100	No	No	Yes	Yes	4	7
371	4x39	I1x51	etb_on	0	100	No	No	No	No	1	7
372	2x39	I1x52	etb_on	0	100	No	No	No	No	8	8
373	2x42	3x45	etb_on	0	100	No	No	No	No	7	7
374	2x42	3x49	etb_on	0	100	No	No	No	No	7	8
375	2x43	3x46	etb_on	0	100	No	No	No	No	8	9
376	2x45	3x42	etb_on	0	100	No	No	No	No	9	8
377	2x46	3x43	etb_on	0	100	Yes	Yes	No	No	9	8
378	2x50	7x46	etb_on	0	100	No	Yes	No	No	9	9
379	2x53	3x36	etb_on	0	100	Yes	No	No	No	8	7
380	2x54	7x42	etb_on	0	100	No	No	No	No	6	7
381	2x56	2x60	etb_on	0	100	No	Yes	No	Yes	6	7
382	2x56	3x32	etb_on	0	100	No	Yes	No	No	6	6
383	2x59	2x60	etb_on	0	100	No	No	No	Yes	6	7
384	2x60	7x38	etb_on	0	100	No	Yes	No	No	7	6
385	2x64	7x35	etb_on	0	100	No	Yes	Yes	Yes	4	3
386	E1x49	E1x51	etb_on	0	100	No	No	No	No	5	2
387	3x33	5x461	etb_on	0	100	Yes	Yes	No	Yes	4	6
388	3x37	5x461	etb_on	0	100	No	No	No	Yes	6	6
389	3x46	3x50	etb_on	0	100	No	No	Yes	No	9	9
390	3x47	5x58	etb_on	0	100	No	No	Yes	Yes	9	9
391	3x50	5x58	etb_on	0	100	Yes	No	Yes	Yes	9	9
392	3x51	3x55	etb_on	0	100	No	Yes	No	No	8	7
393	I2x50	I2x51	etb_on	0	100	No	No	No	No	8	5
394	4x45	4x49	etb_on	0	100	No	No	No	No	6	7
395	4x46	4x50	etb_on	0	100	No	No	No	No	7	9
396	5x36	E2.Q261	etb_on	0	100	No	No	No	Yes	4	2
397	5x34	5x37	etb_on	0	100	No	No	No	No	1	4
398	5x40	6x55	etb_on	0	100	No	Yes	No	No	5	6
399	5x42	5x43	etb_on	0	100	Yes	Yes	No	Yes	4	6
400	5x43	5x461	etb_on	0	100	No	Yes	No	Yes	6	6
401	5x49	5x50	etb_on	0	100	No	No	No	No	6	9
402	5x49	5x53	etb_on	0	100	No	No	No	No	6	7
403	5x50	6x44	etb_on	0	100	No	No	Yes	No	9	9
404	5x58	6x37	etb_on	0	100	Yes	Yes	No	No	9	8
405	5x59	6x38	etb_on	0	100	No	No	No	No	4	5
406	5x62	6x34	etb_on	0	100	No	No	No	No	5	7
407	5x62	6x38	etb_on	0	100	No	No	No	No	5	5
408	5x65	5x66	etb_on	0	100	Yes	Yes	No	No	8	5
409	5x65	6x33	etb_on	0	100	Yes	Yes	No	No	8	8
410	5x68	6x27	etb_on	0	100	No	No	No	No	5	4
411	5x70	I3.Q308	etb_on	0	100	No	No	No	No	0	0
412	6x26	I3.L311	etb_on	0	100	Yes	No	No	No	4	4
413	6x24	6x25	etb_on	0	100	No	No	No	No	2	3
414	6x29	6x32	etb_on	0	100	No	No	No	No	5	7
415	6x47	7x40	etb_on	0	100	No	No	No	No	8	7
416	6x48	6x51	etb_on	0	100	Yes	Yes	No	No	8	6
417	E3.D354	E3.N353	etb_on	0	100	No	Yes	No	No	1	1
418	7x29	7x33	etb_on	0	100	No	No	No	No	3	5
419	7x43	7x48	etb_on	0	100	No	No	No	No	6	6
420	7x49	7x53	etb_on	0	100	Yes	Yes	No	No	9	9
421	1x27	7x35	etb_on	0	100	No	No	Yes	Yes	5	3
422	1x55	1x58	etb_on	0	100	No	No	No	No	3	2
423	1x59	1x60	etb_on	0	100	No	No	No	No	4	6
424	2x56	7x38	etb_on	0	100	No	Yes	No	No	6	6
425	3x51	5x64	etb_on	0	100	No	Yes	Yes	No	8	5
426	3x52	3x56	etb_on	0	100	No	No	No	No	5	7
427	E2.H258	E2.Q261	etb_on	0	100	Yes	Yes	No	Yes	4	2
428	5x40	5x41	etb_on	0	100	No	Yes	No	No	5	5
429	6x28	6x31	etb_on	0	100	No	No	No	No	4	5
430	6x28	6x32	etb_on	0	100	No	No	No	No	4	7
431	E3.D354	E3.N351	etb_on	0	100	No	Yes	No	No	1	1
432	3x52	I2x52	etb_on	0	50	No	No	No	No	5	5
433	6x40	7x52	etb_on	0	50	No	No	No	No	8	7
434	1x43	2x54	etb_on	0	50	No	Yes	No	No	7	6
435	2x41	I1x51	etb_on	0	50	No	No	No	No	6	7
436	3x50	5x61	etb_on	0	50	Yes	No	No	No	9	8
437	1x25	7x28	etb_on	0	50	No	No	No	No	4	3
438	6x50	7x37	etb_on	0	50	No	No	No	No	9	7
439	4x40	4x44	etb_on	0	50	No	No	No	No	3	3
440	2x52	3x31	etb_on	0	50	No	No	No	Yes	7	5
441	I3.I309	I3.L311	etb_on	0	50	No	No	No	No	0	4
442	3x49	4x41	etb_on	0	50	No	No	Yes	Yes	8	5
443	2x38	4x42	etb_on	0	50	No	No	No	No	7	7
444	E3.D354	E3.N356	etb_on	0	50	No	Yes	No	No	1	3
445	E2.Q261	E2x52	etb_on	0	50	No	Yes	No	No	2	5
446	1x30	1x31	etb_on	0	50	No	No	Yes	No	5	4
447	E1x49	Lig	etb_on	0	50	No	No	Yes	Yes	5	0
448	7x49	7x50	etb_on	0	50	Yes	Yes	No	No	9	9
449	3x22	E2.I242	etb_on	0	50	No	No	No	No	3	5
450	I1x49	I1x50	etb_on	0	0	No	No	Yes	Yes	5	7
451	1x54	2x47	etb_on	0	0	No	No	No	No	7	9
452	I2x52	I2x55	etb_on	0	50	No	No	No	No	5	3
453	5x36	5x37	etb_on	0	0	No	No	No	No	4	4
454	2x61	2x65	etb_on	0	0	No	No	No	No	7	4
455	3x27	3x31	etb_on	0	50	No	No	No	Yes	5	5
456	5x40	6x56	etb_on	0	50	No	Yes	No	No	5	6
457	8x52	8x55	etb_on	0	50	No	No	No	No	4	4
458	1x55	8x57	etb_on	0	50	No	No	No	No	3	6
459	6x57	6x61	etb_on	0	50	No	No	No	No	5	3
460	8x47	8x49	etb_on	0	0	No	No	No	No	8	6
461	6x25	6x29	etb_on	0	50	No	No	No	No	3	5
462	1x28	1x31	etb_on	0	0	No	No	Yes	No	3	4
463	4x38	4x41	etb_on	0	50	No	No	Yes	Yes	6	5
464	5x66	6x31	etb_on	0	50	No	No	No	No	5	5
465	4x64	5x32	etb_on	0	0	No	No	Yes	Yes	5	4
466	1x40	1x44	etb_on	0	0	No	No	No	No	4	5
467	1x46	1x50	etb_on	0	0	No	No	Yes	Yes	8	9
468	5x55	6x41	etb_on	0	0	No	No	No	No	5	8
469	1x52	8x57	etb_on	0	50	No	No	No	No	6	6
470	4x40	4x43	etb_on	0	50	No	No	No	No	3	3
471	1x36	2x61	etb_on	0	50	Yes	No	No	No	6	7
472	1x54	2x44	etb_on	0	0	No	No	No	No	7	7
473	1x47	1x51	etb_on	0	0	No	No	No	No	7	4
474	3x56	I2x53	etb_on	0	0	No	No	No	No	7	6
475	4x46	4x47	etb_on	0	0	No	No	No	No	7	3
476	7x32	7x36	etb_on	0	0	No	No	No	No	1	5
477	3x21	E1x52	etb_on	0	0	No	No	Yes	No	8	7
478	1x37	1x41	etb_on	0	0	No	No	No	No	6	4
479	4x55	4x56	etb_on	0	0	No	No	No	Yes	4	5
480	7x55	7x56	etb_on	0	0	No	No	No	No	6	7
481	6x36	6x40	etb_on	0	0	No	No	No	No	8	8
482	4x60	5x31	etb_on	0	0	No	No	No	No	8	3
483	8x48	8x52	etb_on	0	0	No	No	No	No	5	4
484	E2.D246	Lig	etb_on	0	0	No	No	Yes	Yes	1	0
485	I3.I309	I3.Q308	etb_on	0	0	No	No	No	No	0	0
486	5x67	5x69	etb_on	0	0	No	No	No	No	4	0
487	5x64	I2x50	etb_on	0	0	Yes	No	No	No	5	8
488	4x39	I2x57	etb_on	0	0	No	No	No	No	1	6
489	1x23	NT.C90	etb_on	0	0	No	No	No	Yes	4	7
490	1x23	7x24	etb_on	0	0	No	No	No	No	4	8
491	E3.P355	NT.C90	etb_on	0	0	No	No	No	Yes	1	7
492	5x70	5x71	etb_on	0	0	No	No	No	No	0	0
493	7x36	7x37	etb_on	0	0	No	No	No	No	5	7
494	5x71	5x72	etb_on	0	0	No	No	No	No	0	0
495	8x56	8x57	etb_on	0	0	No	No	No	No	5	6
496	6x39	6x43	etb_on	0	0	No	No	No	No	5	6
497	3x53	3x54	etb_on	0	0	No	No	No	No	8	9
498	3x53	I2x53	etb_on	0	0	No	No	No	No	8	6
499	6x35	6x39	etb_on	0	0	No	No	No	No	5	5
500	4x51	4x52	etb_on	0	0	No	No	No	No	4	4
501	1x22	E3.P355	etb_on	0	0	No	No	No	No	4	1
502	1x34	1x38	etb_on	0	0	No	No	No	No	5	5
503	5x30	5x33	etb_on	0	0	No	No	No	No	4	1
504	2x52	2x55	etb_on	0	0	No	No	No	No	7	5

Orange: nodes, hubs and links specific of etb_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of etb_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	etb_off Avg Int. Strength	etb_on Avg Int. Strength	etb_off Num Of Links	etb_on Num Of Links	ConSurf
1	NT.P88	etb_off	0	0	4	1	7
2	1x31	etb_off	33.3333	0	4	3	4
3	1x32	etb_off	0	0	4	3	6
4	1x35	etb_off	66.6667	50	4	3	5
5	1x36	etb_off	0	0	4	2	6
6	1x53	etb_off	66.6667	0	6	3	9
7	2x40	etb_off	0	0	4	2	8
8	2x53	etb_off	100	50	6	3	8
9	2x57	etb_off	33.3333	50	4	3	7
10	E1x52	etb_off	100	0	5	3	7
11	3x29	etb_off	33.3333	50	4	3	5
12	3x50	etb_off	66.6667	0	4	3	9
13	I2x54	etb_off	0	0	4	1	4
14	4x65	etb_off	66.6667	0	4	3	5
15	5x64	etb_off	0	0	4	2	5
16	6x26	etb_off	0	0	4	2	4
17	6x44	etb_off	100	0	4	3	9
18	6x62	etb_off	33.3333	0	5	3	2
19	7x45	etb_off	33.3333	0	4	3	9
20	7x54	etb_off	0	0	4	3	7
21	Lig	Shared	100	100	15	30	0
22	1x50	Shared	0	0	4	4	9
23	I1x50	Shared	33.3333	0	4	4	7
24	2x46	Shared	33.3333	50	4	4	9
25	E1x50	Shared	100	100	7	4	9
26	3x30	Shared	33.3333	0	4	4	6
27	3x33	Shared	66.6667	100	4	4	4
28	4x41	Shared	0	0	4	4	5
29	4x61	Shared	100	100	5	5	5
30	E2.H258	Shared	0	0	4	5	4
31	5x32	Shared	33.3333	0	5	4	4
32	5x35	Shared	66.6667	50	5	4	3
33	5x42	Shared	0	50	4	4	4
34	5x44	Shared	66.6667	0	5	4	6
35	5x46	Shared	100	100	4	4	5
36	5x47	Shared	66.6667	50	4	4	8
37	5x57	Shared	33.3333	0	5	4	7
38	5x58	Shared	0	0	4	4	9
39	5x65	Shared	33.3333	50	4	5	8
40	6x48	Shared	100	100	6	7	8
41	6x52	Shared	66.6667	50	4	4	8
42	7x23	Shared	33.3333	0	4	4	5
43	7x35	Shared	100	50	4	5	3
44	7x49	Shared	0	0	4	4	9
45	8x50	Shared	100	50	6	4	9
46	8x54	Shared	0	50	4	4	7
47	NT.C90	etb_on	0	0	1	4	7
48	1x43	etb_on	33.3333	0	3	4	7
49	2x50	etb_on	33.3333	50	3	4	9
50	2x56	etb_on	33.3333	50	2	4	6
51	2x60	etb_on	0	50	2	4	7
52	2x64	etb_on	0	0	3	4	4
53	3x31	etb_on	33.3333	0	3	4	5
54	3x51	etb_on	0	0	2	4	8
55	4x56	etb_on	33.3333	0	3	4	5
56	E2.Q261	etb_on	0	0	3	5	2
57	5x40	etb_on	0	0	1	4	5
58	5x43	etb_on	33.3333	100	3	4	6
59	5x461	etb_on	0	100	3	5	6
60	E3.D354	etb_on	0	50	2	4	1

Orange: nodes, hubs and links specific of etb_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of etb_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	etb_off Recurrence	etb_on Recurrence	etb_off Hub1?	etb_on Hub1?	etb_off Hub2?	etb_on Hub2?	ConSurf1	ConSurf2
1	2x53	Lig	etb_off	28.6789	0	Yes	No	Yes	Yes	8	0
2	2x60	Lig	etb_off	52.8201	4.16356	No	Yes	Yes	Yes	7	0
3	2x63	Lig	etb_off	49.1816	0.985369	No	No	Yes	Yes	5	0
4	3x29	Lig	etb_off	13.6998	0	Yes	No	Yes	Yes	5	0
5	3x36	Lig	etb_off	27.4034	0	No	No	Yes	Yes	7	0
6	4x65	Lig	etb_off	13.9256	0	Yes	No	Yes	Yes	5	0
7	6x48	Lig	etb_off	78.8915	6.3993	Yes	Yes	Yes	Yes	8	0
8	2x60	2x64	etb_off	51.823	0	No	Yes	No	Yes	7	4
9	1x35	2x64	etb_off	41.5096	0.21275	Yes	No	No	Yes	5	4
10	7x31	7x35	etb_off	29.4729	0.0503882	No	No	Yes	Yes	3	3
11	7x27	7x31	etb_off	25.9585	0	No	No	No	No	3	3
12	6x62	7x27	etb_off	17.5942	0.0205285	Yes	No	No	No	2	3
13	6x62	7x23	etb_off	18.6439	0.0429233	Yes	No	Yes	Yes	2	5
14	1x36	2x64	etb_off	11.3369	0	Yes	No	No	Yes	6	4
15	2x53	2x57	etb_off	10.2307	0	Yes	No	Yes	No	8	7
16	1x50	2x50	etb_off	10.3322	4.18782	Yes	Yes	No	Yes	9	9
17	7x45	7x49	etb_off	100	0	Yes	No	Yes	Yes	9	9
18	6x48	7x45	etb_off	98.7583	5.76478	Yes	Yes	Yes	No	8	9
19	6x40	7x53	etb_off	77.4316	0	No	No	No	No	8	9
20	6x40	7x49	etb_off	78.1202	6.11003	No	No	Yes	Yes	8	9
21	3x41	4x53	etb_off	24.0471	0	No	No	No	No	6	8
22	3x41	4x49	etb_off	25.3941	1.04882	No	No	No	No	6	7
23	3x42	4x49	etb_off	26.7336	0	No	No	No	No	8	7
24	2x40	8x50	etb_off	50.8711	0	Yes	No	Yes	Yes	8	9
25	I1x52	I2x54	etb_off	36.1628	0.905121	No	No	Yes	No	8	4
26	2x39	3x50	etb_off	12.8871	0	No	No	Yes	No	8	9
27	2x40	3x50	etb_off	17.6769	0	Yes	No	Yes	No	8	9
28	2x45	4x50	etb_off	10.1629	0	No	No	No	No	9	9
29	2x53	2x56	etb_off	13.1128	5.19185	Yes	No	No	Yes	8	6
30	2x56	3x31	etb_off	11.683	0	No	Yes	No	Yes	6	5
31	2x63	E1x50	etb_off	48.1619	0.00373246	No	No	Yes	Yes	5	9
32	E1x50	E2.I242	etb_off	33.9918	0	Yes	Yes	No	No	9	5
33	E2.I242	E2.R253	etb_off	32.927	2.27493	No	No	No	No	5	5
34	E1x49	E2.R253	etb_off	25.4844	5.66214	No	No	No	No	5	5
35	E1x49	E2.L252	etb_off	24.1713	0	No	No	No	No	5	3
36	E2.I254	E2.L252	etb_off	21.5224	0	No	No	No	No	4	3
37	E2.I254	E2x51	etb_off	11.3745	0	No	No	No	No	4	4
38	3x29	4x61	etb_off	12.1383	1.61802	Yes	No	Yes	Yes	5	5
39	5x42	5x461	etb_off	20.3108	0	Yes	Yes	No	Yes	4	6
40	4x48	4x52	etb_off	33.5629	0.62332	No	No	No	No	3	4
41	4x44	4x48	etb_off	32.5507	0	No	No	No	No	3	3
42	4x41	4x44	etb_off	31.5837	3.139	Yes	Yes	No	No	5	3
43	3x52	4x41	etb_off	21.5675	0	No	No	Yes	Yes	5	5
44	3x48	3x52	etb_off	22.7189	0	No	No	No	No	6	5
45	3x48	5x57	etb_off	20.6908	1.04882	No	No	Yes	Yes	6	7
46	5x46	5x461	etb_off	17.3571	2.50075	Yes	Yes	No	Yes	5	6
47	4x56	5x46	etb_off	15.9574	2.19468	No	Yes	Yes	Yes	5	5
48	5x64	I2x54	etb_off	34.3342	0	Yes	No	Yes	No	5	4
49	5x64	5x68	etb_off	31.2639	0	Yes	No	No	No	5	5
50	5x68	6x30	etb_off	21.9475	1.93715	No	No	No	No	5	7
51	5x65	6x30	etb_off	15.1033	2.83294	Yes	Yes	No	No	8	7
52	4x61	5x35	etb_off	32.799	7.28389	Yes	Yes	Yes	Yes	5	3
53	5x39	5x43	etb_off	11.0998	1.85317	No	No	No	Yes	7	6
54	5x35	5x39	etb_off	10.2457	1.30263	Yes	Yes	No	No	3	7
55	5x32	5x35	etb_off	36.7724	0	Yes	Yes	Yes	Yes	4	3
56	5x32	E2.Q261	etb_off	16.4165	4.20648	Yes	Yes	No	Yes	4	2
57	5x44	6x52	etb_off	13.2709	3.92281	Yes	Yes	Yes	Yes	6	8
58	5x47	6x49	etb_off	20.1189	9.2341	Yes	Yes	No	No	8	5
59	5x65	6x34	etb_off	11.4309	0	Yes	Yes	No	No	8	7
60	5x58	6x34	etb_off	10.1893	0	Yes	Yes	No	No	9	7
61	8x47	8x50	etb_off	14.1701	2.09577	No	No	Yes	Yes	8	9
62	6x49	6x53	etb_off	14.6405	7.92587	No	No	No	No	5	6
63	6x53	6x57	etb_off	13.2822	6.61391	No	No	No	No	6	5
64	7x23	E3.D354	etb_off	13.3236	0	Yes	Yes	No	Yes	5	1
65	E3.D354	E3.P355	etb_off	11.4422	5.65281	No	Yes	No	No	1	1
66	6x57	7x30	etb_off	11.9427	2.65564	No	No	No	No	5	3
67	7x54	8x54	etb_off	11.525	5.21424	Yes	No	Yes	Yes	7	7
68	6x48	6x52	etb_off	20.8413	4.33525	Yes	Yes	Yes	Yes	8	8
69	3x33	Lig	Shared	11.9577	32.1383	Yes	Yes	Yes	Yes	4	0
70	5x43	Lig	Shared	11.9916	54.3838	No	Yes	Yes	Yes	6	0
71	6x52	Lig	Shared	16.9282	13.9501	Yes	Yes	Yes	Yes	8	0
72	1x35	7x35	Shared	31.5574	25.0653	Yes	No	Yes	Yes	5	3
73	2x46	7x49	Shared	37.7055	91.6169	Yes	Yes	Yes	Yes	9	9
74	8x50	8x54	Shared	19.8555	78.893	Yes	Yes	Yes	Yes	9	7
75	7x53	8x50	Shared	68.1943	80.1209	No	No	Yes	Yes	9	9
76	3x38	4x50	Shared	18.5837	67.0835	No	No	No	No	7	9
77	3x38	4x53	Shared	21.3305	67.7516	No	No	No	No	7	8
78	2x46	3x42	Shared	28.0656	98.8205	Yes	Yes	No	No	9	8
79	2x40	I1x52	Shared	39.6734	65.1818	Yes	No	No	No	8	8
80	3x33	4x61	Shared	12.2625	13.3883	Yes	Yes	Yes	Yes	4	5
81	4x61	4x65	Shared	11.382	16.1485	Yes	Yes	Yes	No	5	5
82	3x36	5x461	Shared	38.5107	12.1939	No	No	No	Yes	7	6
83	4x56	5x42	Shared	20.4086	32.8606	No	Yes	Yes	Yes	5	4
84	4x52	4x56	Shared	34.733	34.7977	No	No	No	Yes	4	5
85	2x39	3x49	Shared	11.1901	56.5113	No	No	No	No	8	8
86	5x47	6x52	Shared	23.1554	13.0804	Yes	Yes	Yes	Yes	8	8
87	3x36	6x48	Shared	12.0066	10.0049	No	No	Yes	Yes	7	8
88	7x23	Lig	etb_on	0	12.0484	Yes	Yes	Yes	Yes	5	0
89	7x23	NT.C90	etb_on	0	11.1638	Yes	Yes	No	Yes	5	7
90	7x35	Lig	etb_on	0	31.0093	Yes	Yes	Yes	Yes	3	0
91	1x35	7x39	etb_on	2.87843	24.2218	Yes	No	No	No	5	5
92	1x39	7x39	etb_on	0	21.0249	No	No	No	No	7	5
93	1x39	2x57	etb_on	2.98378	14.5305	No	No	Yes	No	7	7
94	1x43	2x57	etb_on	4.39478	12.3152	No	Yes	Yes	No	7	7
95	2x45	3x42	etb_on	0	99.4121	No	No	No	No	9	8
96	2x45	4x46	etb_on	8.73312	100	No	No	No	No	9	7
97	4x46	4x50	etb_on	0	66.434	No	No	No	No	7	9
98	3x37	4x53	etb_on	1.4712	68.0875	No	No	No	No	6	8
99	3x37	5x461	etb_on	0	68.4234	No	No	No	Yes	6	6
100	3x33	5x461	etb_on	0	33.7004	Yes	Yes	No	Yes	4	6
101	5x43	5x461	etb_on	0	26.9092	No	Yes	No	Yes	6	6
102	4x46	4x47	etb_on	0	34.2714	No	No	No	No	7	3
103	4x47	4x51	etb_on	0.00376265	34.4039	No	No	No	No	3	4
104	4x51	4x52	etb_on	0	34.5364	No	No	No	No	4	4
105	5x42	5x43	etb_on	0	27.7527	Yes	Yes	No	Yes	4	6
106	7x49	7x53	etb_on	0	84.9974	Yes	Yes	No	No	9	9
107	1x56	8x54	etb_on	4.37596	70.4333	No	No	Yes	Yes	7	7
108	1x56	8x53	etb_on	1.46367	69.8156	No	No	No	No	7	4
109	8x53	I1x50	etb_on	0	69.0337	No	No	Yes	Yes	4	7
110	2x40	I1x50	etb_on	1.06107	65.96	Yes	No	Yes	Yes	8	7
111	2x39	I1x52	etb_on	0	63.7541	No	No	No	No	8	8
112	2x42	3x49	etb_on	0	49.1005	No	No	No	No	7	8
113	2x42	3x46	etb_on	1.19652	47.3873	No	No	No	No	7	9
114	2x53	3x35	etb_on	2.98378	10.5293	Yes	No	No	No	8	8
115	E1x49	Lig	etb_on	0	13.2969	No	No	Yes	Yes	5	0
116	3x46	3x50	etb_on	0	45.6554	No	No	Yes	No	9	9
117	3x47	5x58	etb_on	0	14.3681	No	No	Yes	Yes	9	9
118	3x50	5x58	etb_on	0	21.135	Yes	No	Yes	Yes	9	9
119	3x47	5x57	etb_on	6.28363	10.337	No	No	Yes	Yes	9	7
120	3x50	5x61	etb_on	0	25.7633	Yes	No	No	No	9	8
121	5x61	5x65	etb_on	1.29435	17.7814	No	No	Yes	Yes	8	8
122	4x65	E2x52	etb_on	2.45701	15.443	Yes	No	No	No	5	5
123	E2.Q261	E2x52	etb_on	0	14.6611	No	Yes	No	No	2	5
124	5x65	5x66	etb_on	0	13.4816	Yes	Yes	No	No	8	5
125	6x28	6x32	etb_on	0	10.6039	No	No	No	No	4	7
126	6x28	6x31	etb_on	0	11.6135	No	No	No	No	4	5
127	5x66	6x31	etb_on	0	12.4701	No	No	No	No	5	5

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
2x53	Lig	etb_off	11.43	0	1	0	1	0
2x60	Lig	Shared	5.92	6.375	0	1	1	0
2x63	Lig	Shared	5.05333	4.36	0	1	1	0
3x29	Lig	etb_off	4.94667	0	1	1	1	0
3x32	Lig	Shared	20.8633	9.855	1	1	1	0
3x33	Lig	Shared	14.27	9.28	1	1	1	0
3x36	Lig	etb_off	4.68333	0	1	0	1	0
4x65	Lig	etb_off	4.31	0	1	1	1	0
5x43	Lig	Shared	9.39667	6.26	1	1	1	0
6x48	Lig	Shared	13.2	4.685	1	1	1	0
6x51	Lig	Shared	5.78333	21.36	1	1	1	0
6x52	Lig	Shared	4.93667	5.29	1	1	1	0
6x55	Lig	Shared	9.92333	22.71	1	1	1	0
7x38	Lig	etb_off	8.03	0	0	1	1	0
7x24	NT.C90	Shared	4.85333	7.28	0	1	2	2
1x24	7x27	etb_off	4.37667	0	0	0	2	1
1x27	7x31	Shared	3.80667	4.995	0	1	2	1
1x28	7x35	etb_off	5.57333	0	0	0	2	1
1x31	1x35	etb_off	5.64	0	4	0	2	2
1x31	7x35	etb_off	18.2267	0	4	0	2	1
1x32	E1.E165	etb_off	3.6	0	0	1	2	1
1x35	2x64	Shared	3.66	3.43	4	1	2	2
1x35	7x35	Shared	5.03667	5.23	4	1	2	1
1x42	7x42	Shared	5.38333	5.655	0	0	2	1
2x53	2x56	Shared	8.67333	10.715	1	0	1	2
2x53	2x57	etb_off	3.53333	0	1	0	1	2
2x53	3x32	etb_off	5.77	0	1	0	1	1
2x53	3x35	Shared	5.11	3.485	1	0	1	2
2x53	7x46	etb_off	5.11333	0	1	0	1	2
2x54	7x46	etb_off	5.16	0	0	0	2	2
2x59	E1x52	etb_off	12.14	0	0	1	1	2
2x59	3x28	etb_off	5.63333	0	0	1	1	2
2x63	E1x50	Shared	6.96	7.54	0	1	1	1
E1x49	E2.R253	Shared	14.69	5.955	0	1	1	2
E1x50	E1x51	etb_off	3.6	0	2	1	1	2
E1x50	E1x52	etb_off	13.3633	0	2	1	1	2
3x25	E1x50	Shared	8.27333	7.835	2	1	2	1
E1x50	E2.I242	etb_off	4.30667	0	2	1	1	2
E1x50	E2x50	Shared	8.70667	10.45	2	1	1	2
E1x51	E1x52	etb_off	9.63	0	2	0	2	2
3x25	E2x50	Shared	7.28	7.28	2	1	2	2
3x28	3x29	Shared	3.53	4.415	0	0	2	1
3x29	4x61	Shared	5.76333	6.285	1	1	1	2
3x29	4x65	Shared	15.41	9.39	1	1	1	1
3x32	3x33	Shared	8.13667	7.46	1	1	1	1
3x33	4x61	Shared	11.7	12.15	1	1	1	2
3x33	5x43	etb_off	4.7	0	1	1	1	1
3x36	5x461	Shared	4.20667	6.31	1	0	1	2
3x36	6x48	Shared	6.95	5.52	1	0	1	1
4x61	4x65	Shared	7.77333	8.745	1	1	2	1
4x61	5x39	Shared	8.55	10.8	1	1	2	2
4x65	E2x52	Shared	7.71333	6.7	1	1	1	2
E2.I242	E2x50	etb_off	5.45667	0	2	0	2	2
E2.I243	E2x51	etb_off	3.80667	0	0	0	2	1
E2.D246	E2.Y251	etb_off	6.13	0	0	1	1	2
E2.K248	E2.Y247	Shared	10.7467	11.94	0	0	2	1
5x39	5x43	Shared	5.64	9.165	1	1	2	1
5x42	5x461	etb_off	4.18	0	1	1	2	2
5x44	5x47	Shared	6.07	8.575	1	1	2	2
5x44	6x52	Shared	8.29667	8.485	1	1	2	1
5x47	6x52	Shared	17.3467	9.615	1	1	2	1
6x44	6x48	Shared	14.6967	5.01	1	1	2	1
6x44	7x45	Shared	6.04	9.67	1	1	2	2
6x48	6x52	Shared	6.34667	4.235	1	1	1	1
6x48	7x41	Shared	8.64667	9.075	1	1	1	2
6x48	7x45	Shared	6.78	6.215	1	1	1	2
6x51	6x55	etb_off	4.05	0	1	1	1	1
6x51	7x37	etb_off	3.99	0	1	1	1	2
6x54	7x34	Shared	4.11667	10.31	0	0	2	1
6x55	7x34	etb_off	9.13	0	1	1	1	1
6x62	E3.Q352	etb_off	10.52	0	7	1	1	1
6x62	7x23	Shared	4.8	8.23	7	1	1	1
6x62	7x27	Shared	9.76667	3.515	7	1	1	1
7x23	E3.Q352	Shared	5.45	8.175	7	1	1	1
7x31	7x35	Shared	7.42333	5.275	0	1	1	1
7x23	7x24	etb_off	3.25	0	7	1	1	2
6x58	6x62	etb_off	3.18333	0	0	0	1	1
6x62	7x26	etb_off	3.12667	0	7	1	1	2
1x27	7x28	etb_off	3.09667	0	0	1	2	2
E2.I254	E2.M245	etb_off	2.91667	0	0	1	1	1
E2.I254	E2x51	Shared	2.85333	4.995	0	1	1	1
E2.M245	NT.P88	etb_off	2.79667	0	0	0	1	2
2x60	2x64	etb_off	2.74667	0	0	1	1	2
E1x49	E2.L252	etb_off	2.71333	0	0	1	1	1
7x42	Lig	etb_off	2.14	0	0	0	1	0
E2.I254	E2.L252	etb_off	1.90333	0	0	1	1	1
E2.I242	E2.R253	Shared	1.67333	4.385	2	0	2	2
7x23	E3.D354	etb_off	1.58667	0	7	1	1	2
3x21	E1x50	etb_off	1.40667	0	0	0	2	1
E2.Y247	NT.P88	etb_off	1.39	0	0	1	1	2
7x27	7x31	etb_off	1.38333	0	0	1	1	1
1x22	1x25	etb_off	1.37	0	0	0	2	1
1x25	1x26	etb_off	1.36667	0	0	1	1	2
E2.D246	E2.G249	Shared	1.11667	0.84	0	1	1	2
E2.L252	E2.S250	Shared	0.5	4.505	0	1	1	2
6x58	Lig	etb_on	0	11.255	0	0	1	0
E2.M245	Lig	etb_on	0	13.99	0	0	1	0
E3.Q352	Lig	etb_on	0	11.125	7	1	1	0
6x62	Lig	etb_on	0	6.02	7	1	1	0
7x23	Lig	etb_on	0	8.735	7	1	1	0
E2.Y247	Lig	etb_on	0	26.47	0	1	1	0
7x27	Lig	etb_on	0	12.235	0	1	1	0
E2.I254	Lig	etb_on	0	11.335	0	1	1	0
1x25	Lig	etb_on	0	8.915	0	1	1	0
E2.L252	Lig	etb_on	0	4.385	0	1	1	0
7x31	Lig	etb_on	0	6.73	0	1	1	0
7x34	Lig	etb_on	0	14.67	0	1	1	0
E2x51	Lig	etb_on	0	3.905	0	1	1	0
E1.E165	Lig	etb_on	0	5.205	0	0	1	0
7x35	Lig	etb_on	0	7.2	4	1	1	0
2x59	Lig	etb_on	0	4.415	0	1	1	0
E1x50	Lig	etb_on	0	4.695	2	1	1	0
7x23	NT.C90	etb_on	0	3.48	7	1	1	2
1x25	7x24	etb_on	0	4.91	0	1	1	2
1x27	2x64	etb_on	0	3.57	0	1	2	2
1x32	2x64	etb_on	0	4.23	0	1	2	2
2x53	3x36	etb_on	0	4.155	1	0	1	1
2x54	7x42	etb_on	0	5.42	0	0	2	1
2x56	2x60	etb_on	0	5.385	0	1	2	1
2x56	3x32	etb_on	0	13.705	0	1	2	1
2x59	2x60	etb_on	0	4.25	0	1	1	1
2x60	7x38	etb_on	0	7.08	0	1	1	1
2x64	7x35	etb_on	0	14.655	0	1	2	1
E1x49	E1x51	etb_on	0	8.855	0	1	1	2
3x33	5x461	etb_on	0	3.585	1	1	1	2
5x40	6x55	etb_on	0	7.74	0	0	2	1
5x42	5x43	etb_on	0	3.42	1	1	2	1
5x43	5x461	etb_on	0	3.515	1	1	1	2
6x48	6x51	etb_on	0	4.555	1	1	1	1
1x27	7x35	etb_on	0	4.23	0	1	2	1
2x56	7x38	etb_on	0	4.2	0	1	2	1
1x25	7x28	etb_on	0	3.095	0	1	1	2
E1x49	Lig	etb_on	0	2.52	0	1	1	0
1x28	1x31	etb_on	0	1.86	0	0	2	2
3x21	E1x52	etb_on	0	1.505	0	0	2	2
E2.D246	Lig	etb_on	0	1.385	0	1	1	0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	etb_off	5X93-ET_B-K-8794 5XPR-ET_B-Bosentan 6K1Q-ET_B-IRL2500
	etb_on	8IY5-ET_B-Endothelin-1-Gi1/β1/γ2 8HBD-ET_B-IRL1620-Gi1/β1/γ2

Network Difference
Value	etb_off	etb_on
I_min	3.42333	3.21
Number of Linked Nodes	307	311
Number of Specific Nodes	6 (1.95%)	10 (3.22%)
Number of Shared Nodes	301 (98.05%)	301 (96.78%)
Number of Links	345	346
Number of Specific Links	158 (45.80%)	159 (45.95%)
Number of Shared Links	187 (54.20%)	187 (54.05%)
Number of Hubs	46	40
Number of Specific Hubs	20 (43.48%)	14 (35.00%)
Number of Shared Hubs	26 (56.52%)	26 (65.00%)
Average % Shared Neighbours (Jaccard)	40.51
Average % Shared Neighbours (Otsuka)	50.14
Average % Shared Neighbours (Overlap Coefficient)	58.71
Average % Shared Cliques (k3-6)	81.88
Graphlets Similarity	0.608805

Paths Difference
Value	etb_off	etb_on
Number Of Nodes in MetaPath	83	59
Specific Nodes in MetaPath	45 (54.22%)	21 (35.59%)
Shared Nodes in MetaPath	301 (98.05%)	301 (98.05%)
Number Of Links MetaPath	87	59
Specific Links in MetaPath	68 (78.16%)	40 (67.80%)
Shared Links in MetaPath	187 (54.20%)	187 (54.20%)
Number of Shortest Paths	67693	83722
Length Of Smallest Path	3	3
Average Path Length	13.4476	20.4691
Length of Longest Path	31	54
Minimum Path Strength	0.543333	0.8
Average Path Strength	5.75945	5.32813
Maximum Path Strength	17.0317	23.915
Minimum Path Correlation	0.7	0.7
Average Path Correlation	0.931708	0.93467
Maximum Path Correlation	0.99	0.99
Minimum % Of Corr. Nodes	4	2.17391
Average % Of Corr. Nodes	50.1086	43.2515
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	44.3061	35.3565
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

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