psnGPCR

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Orange: nodes, hubs and links specific of etb_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of etb_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	etb_off Int. Strength	etb_on Int. Strength	etb_off Hub1?	etb_on Hub1?	etb_off Hub2?	etb_on Hub2?	ConSurf1	ConSurf2
1	1x24	7x27	etb_off	100	0	No	No	No	No	4	3
2	1x27	7x31	etb_off	100	0	No	No	No	No	5	3
3	1x27	7x32	etb_off	100	0	No	No	No	No	5	1
4	1x28	7x35	etb_off	100	0	No	No	Yes	Yes	3	3
5	1x31	7x35	etb_off	100	0	Yes	Yes	Yes	Yes	4	3
6	1x32	E1.E165	etb_off	100	0	Yes	No	No	No	6	4
7	1x35	2x64	etb_off	100	0	Yes	No	No	No	5	4
8	1x50	2x47	etb_off	100	0	Yes	No	No	No	9	9
9	1x50	7x50	etb_off	100	0	Yes	No	No	No	9	9
10	1x53	2x43	etb_off	100	0	Yes	No	No	No	9	8
11	1x53	7x50	etb_off	100	0	Yes	No	No	No	9	9
12	1x53	7x53	etb_off	100	0	Yes	No	No	No	9	9
13	1x54	2x48	etb_off	100	0	No	No	No	No	7	6
14	1x55	1x59	etb_off	100	0	No	No	No	No	3	4
15	1x56	8x54	etb_off	100	0	No	No	Yes	No	7	7
16	8x50	I1x50	etb_off	100	0	Yes	Yes	Yes	No	9	7
17	2x39	3x50	etb_off	100	0	No	No	Yes	No	8	9
18	2x40	3x50	etb_off	100	0	Yes	No	Yes	No	8	9
19	2x40	8x50	etb_off	100	0	Yes	No	Yes	Yes	8	9
20	2x46	3x39	etb_off	100	0	Yes	Yes	No	No	9	9
21	2x48	4x50	etb_off	100	0	No	No	No	No	6	9
22	2x53	3x32	etb_off	100	0	Yes	Yes	No	No	8	6
23	2x53	Lig	etb_off	100	0	Yes	Yes	Yes	Yes	8	0
24	2x54	7x46	etb_off	100	0	No	No	No	No	6	9
25	2x59	E1x52	etb_off	100	0	No	No	Yes	No	6	7
26	2x59	3x28	etb_off	100	0	No	No	No	No	6	5
27	2x62	2x66	etb_off	100	0	No	No	No	No	4	5
28	2x62	E1x52	etb_off	100	0	No	No	Yes	No	4	7
29	E1x50	E1x51	etb_off	100	0	Yes	Yes	No	No	9	2
30	E1x50	E1x52	etb_off	100	0	Yes	Yes	Yes	No	9	7
31	3x29	4x61	etb_off	100	0	Yes	No	Yes	Yes	5	5
32	3x29	Lig	etb_off	100	0	Yes	No	Yes	Yes	5	0
33	3x33	5x43	etb_off	100	0	Yes	No	No	No	4	6
34	3x36	Lig	etb_off	100	0	No	No	Yes	Yes	7	0
35	3x38	4x53	etb_off	100	0	No	No	No	No	7	8
36	3x40	6x44	etb_off	100	0	No	No	Yes	No	8	9
37	3x41	4x49	etb_off	100	0	No	No	No	No	6	7
38	3x41	4x53	etb_off	100	0	No	No	No	No	6	8
39	3x42	4x49	etb_off	100	0	No	No	No	No	8	7
40	3x46	6x37	etb_off	100	0	No	No	No	No	9	8
41	3x48	3x52	etb_off	100	0	No	No	No	Yes	6	5
42	3x49	4x45	etb_off	100	0	No	Yes	No	No	8	6
43	3x50	6x33	etb_off	100	0	Yes	No	No	No	9	8
44	3x50	6x37	etb_off	100	0	Yes	No	No	No	9	8
45	6x26	I2x50	etb_off	100	0	Yes	No	No	No	4	8
46	5x64	I2x54	etb_off	100	0	Yes	No	Yes	No	5	4
47	4x41	4x44	etb_off	100	0	Yes	Yes	No	No	5	3
48	4x63	5x32	etb_off	100	0	No	No	Yes	No	5	4
49	4x64	E2.Q261	etb_off	100	0	No	No	No	Yes	5	2
50	4x65	Lig	etb_off	100	0	Yes	No	Yes	Yes	5	0
51	E2.I242	E2x50	etb_off	100	0	No	No	No	No	5	9
52	E2.I243	E2x51	etb_off	100	0	No	No	No	No	1	4
53	E2.D246	E2.Y251	etb_off	100	0	No	No	No	No	1	5
54	E2.L252	E2.Y247	etb_off	100	0	No	No	No	No	3	2
55	5x29	E2.K262	etb_off	100	0	No	No	No	No	3	1
56	5x41	6x56	etb_off	100	0	No	No	No	No	5	6
57	5x41	6x59	etb_off	100	0	No	No	No	No	5	5
58	5x42	5x461	etb_off	100	0	Yes	Yes	No	Yes	4	6
59	5x46	5x49	etb_off	100	0	Yes	Yes	No	No	5	6
60	5x58	5x62	etb_off	100	0	Yes	Yes	No	No	9	5
61	5x61	5x65	etb_off	100	0	No	No	Yes	No	8	8
62	5x64	5x68	etb_off	100	0	Yes	No	No	No	5	5
63	5x68	6x30	etb_off	100	0	No	No	No	No	5	7
64	6x24	6x26	etb_off	100	0	No	No	Yes	No	2	4
65	6x24	6x27	etb_off	100	0	No	No	No	No	2	4
66	6x26	6x30	etb_off	100	0	Yes	No	No	No	4	7
67	6x32	8x47	etb_off	100	0	No	No	No	No	7	8
68	6x32	8x48	etb_off	100	0	No	No	No	No	7	5
69	6x32	8x49	etb_off	100	0	No	No	No	No	7	6
70	6x35	7x56	etb_off	100	0	No	No	No	No	5	7
71	6x36	8x47	etb_off	100	0	No	No	No	No	8	8
72	6x39	7x56	etb_off	100	0	No	No	No	No	5	7
73	6x40	7x53	etb_off	100	0	No	No	No	No	8	9
74	6x44	6x48	etb_off	100	0	Yes	No	Yes	Yes	9	8
75	6x51	7x37	etb_off	100	0	No	No	No	No	6	7
76	7x26	7x30	etb_off	100	0	No	No	No	No	2	3
77	7x38	Lig	etb_off	100	0	No	No	Yes	Yes	6	0
78	7x54	8x55	etb_off	100	0	Yes	No	No	No	7	4
79	8x51	8x52	etb_off	100	0	No	No	No	No	8	4
80	8x51	8x55	etb_off	100	0	No	No	No	No	8	4
81	1x36	2x65	etb_off	100	0	Yes	No	No	No	6	4
82	1x43	2x58	etb_off	100	0	No	No	No	No	7	9
83	1x52	8x58	etb_off	100	0	No	No	No	No	6	6
84	2x53	2x57	etb_off	100	0	Yes	Yes	Yes	Yes	8	7
85	E1x50	E2.I242	etb_off	100	0	Yes	Yes	No	No	9	5
86	6x51	6x55	etb_off	100	0	No	No	No	No	6	6
87	6x55	7x34	etb_off	100	0	No	No	No	No	6	4
88	7x23	E3.D354	etb_off	100	0	Yes	No	No	Yes	5	1
89	1x58	1x59	etb_off	100	0	No	No	No	No	2	4
90	I1x52	I2x54	etb_off	100	0	No	No	Yes	No	8	4
91	5x68	I2x50	etb_off	100	0	No	No	No	No	5	8
92	6x28	8x48	etb_off	66.6667	0	No	No	No	No	4	5
93	6x29	6x33	etb_off	66.6667	0	No	No	No	No	5	8
94	1x53	1x57	etb_off	33.3333	0	Yes	No	No	No	9	7
95	6x31	6x35	etb_off	33.3333	0	No	No	No	No	5	5
96	I2x52	I2x54	etb_off	33.3333	0	No	No	Yes	No	5	4
97	1x22	1x23	etb_off	33.3333	0	No	No	No	No	4	4
98	6x49	6x50	etb_off	33.3333	0	No	No	No	No	5	9
99	2x56	3x31	etb_off	33.3333	0	No	Yes	No	No	6	5
100	7x23	7x24	etb_off	33.3333	0	Yes	No	No	No	5	8
101	3x43	6x44	etb_off	66.6667	0	No	No	Yes	No	8	9
102	5x32	5x35	etb_off	33.3333	0	Yes	No	Yes	Yes	4	3
103	6x58	6x62	etb_off	33.3333	0	No	No	Yes	Yes	4	2
104	7x45	7x49	etb_off	33.3333	0	Yes	No	Yes	Yes	9	9
105	1x27	7x28	etb_off	33.3333	0	No	No	No	No	5	3
106	E2.H258	E2.I243	etb_off	66.6667	0	Yes	Yes	No	No	4	1
107	3x47	5x57	etb_off	33.3333	0	No	No	Yes	No	9	7
108	3x45	4x45	etb_off	33.3333	0	No	No	No	No	7	6
109	7x36	7x40	etb_off	0	0	No	No	No	No	5	7
110	E2.I254	E2x51	etb_off	33.3333	0	No	No	No	No	4	4
111	7x29	7x30	etb_off	66.6667	0	No	No	No	No	3	3
112	E2.M245	NT.P88	etb_off	33.3333	0	No	Yes	No	No	1	0
113	1x41	1x45	etb_off	33.3333	0	No	No	No	No	4	5
114	2x60	2x64	etb_off	33.3333	0	No	Yes	No	No	7	4
115	E3.N351	E3.N356	etb_off	33.3333	0	No	No	No	No	1	3
116	2x39	3x49	etb_off	66.6667	0	No	No	No	Yes	8	8
117	3x55	I2x50	etb_off	33.3333	0	No	No	No	No	7	8
118	E2.R253	E2.T244	etb_off	66.6667	0	No	No	No	No	5	1
119	2x41	4x42	etb_off	33.3333	0	No	No	No	No	6	7
120	5x53	5x57	etb_off	0	0	No	No	Yes	No	7	7
121	1x51	2x51	etb_off	33.3333	0	No	No	No	No	4	7
122	5x31	5x32	etb_off	66.6667	0	No	No	Yes	No	3	4
123	1x42	7x43	etb_off	0	0	No	No	No	No	8	6
124	1x58	I1x51	etb_off	0	0	No	No	No	No	2	7
125	3x56	5x64	etb_off	33.3333	0	No	No	Yes	No	7	5
126	1x26	1x30	etb_off	33.3333	0	No	No	No	No	5	5
127	6x27	I3.L311	etb_off	33.3333	0	No	No	No	No	4	4
128	E1x49	E2.L252	etb_off	33.3333	0	No	No	No	No	5	3
129	5x65	6x34	etb_off	33.3333	0	Yes	No	No	No	8	7
130	7x42	Lig	etb_off	33.3333	0	No	No	Yes	Yes	7	0
131	6x43	7x49	etb_off	0	0	No	No	Yes	Yes	6	9
132	2x41	4x46	etb_off	0	0	No	No	No	No	6	7
133	1x54	1x58	etb_off	33.3333	0	No	No	No	No	7	2
134	7x51	7x55	etb_off	0	0	No	No	No	No	7	6
135	6x39	7x52	etb_off	0	0	No	No	No	No	5	7
136	3x34	4x57	etb_off	0	0	No	No	No	No	6	7
137	5x58	6x34	etb_off	0	0	Yes	Yes	No	No	9	7
138	1x36	1x40	etb_off	0	0	Yes	No	No	No	6	4
139	6x38	6x42	etb_off	0	0	No	No	No	No	5	5
140	1x56	8x57	etb_off	0	0	No	No	No	No	7	6
141	5x41	6x60	etb_off	0	0	No	No	No	No	5	4
142	5x36	E2x52	etb_off	0	0	No	No	No	No	4	5
143	7x54	7x55	etb_off	0	0	Yes	No	No	No	7	6
144	3x22	E2.D241	etb_off	0	0	No	No	No	No	3	4
145	1x44	1x48	etb_off	0	0	No	No	No	No	5	5
146	1x47	2x55	etb_off	0	0	No	No	No	No	7	5
147	2x55	2x551	etb_off	0	0	No	No	No	No	5	5
148	1x36	2x64	etb_off	33.3333	0	Yes	No	No	No	6	4
149	1x32	2x65	etb_off	33.3333	0	Yes	No	No	No	6	4
150	3x21	E1x50	etb_off	0	0	No	No	Yes	Yes	8	9
151	7x27	7x31	etb_off	0	0	No	No	No	No	3	3
152	1x22	1x25	etb_off	0	0	No	No	No	No	4	4
153	1x25	1x26	etb_off	33.3333	0	No	No	No	No	4	5
154	I2x53	I2x57	etb_off	33.3333	0	No	No	No	No	6	6
155	I2x54	I2x55	etb_off	0	0	Yes	No	No	No	4	3
156	3x53	I2x51	etb_off	0	0	No	No	No	No	8	5
157	E2.K248	NT.P87	etb_off	33.3333	0	No	No	No	No	1	0
158	8x55	8x59	etb_off	0	0	No	No	No	No	4	5
159	4x47	4x51	etb_off	0	0	No	No	No	No	3	4
160	4x44	4x48	etb_off	0	0	No	No	No	No	3	3
161	5x58	5x59	etb_off	0	0	Yes	Yes	No	No	9	4
162	4x41	I2x53	etb_off	0	0	Yes	Yes	No	No	5	6
163	NT.P88	NT.P89	etb_off	0	0	No	No	No	No	0	0
164	NT.P87	NT.S86	etb_off	0	0	No	No	No	No	0	0
165	I2x55	I2x56	etb_off	0	0	No	No	No	No	3	3
166	5x62	5x63	etb_off	0	0	No	No	No	No	5	4
167	5x59	5x63	etb_off	0	0	No	No	No	No	4	4
168	5x44	5x45	etb_off	0	0	Yes	Yes	No	No	6	4
169	E2.Y251	NT.I85	etb_off	0	0	No	No	No	No	5	0
170	5x64	5x67	etb_off	0	0	Yes	No	No	No	5	4
171	1x55	CT.W404	etb_off	0	0	No	No	No	No	3	0
172	7x24	NT.C90	Shared	100	100	No	No	No	No	8	7
173	1x23	1x24	Shared	100	100	No	No	No	No	4	4
174	1x29	1x32	Shared	100	100	No	No	Yes	No	3	6
175	1x31	1x34	Shared	100	0	Yes	Yes	No	No	4	5
176	1x31	1x35	Shared	100	100	Yes	Yes	Yes	No	4	5
177	1x31	7x32	Shared	100	100	Yes	Yes	No	No	4	1
178	1x35	7x35	Shared	100	50	Yes	No	Yes	Yes	5	3
179	1x35	7x39	Shared	100	100	Yes	No	No	No	5	5
180	1x38	7x39	Shared	100	0	No	No	No	No	5	5
181	1x39	2x61	Shared	100	100	No	No	No	No	7	7
182	1x42	7x42	Shared	100	100	No	No	No	No	8	7
183	1x42	7x47	Shared	100	0	No	No	No	No	8	8
184	1x43	1x47	Shared	100	100	No	No	No	No	7	7
185	1x43	2x57	Shared	100	100	No	No	Yes	Yes	7	7
186	1x49	7x50	Shared	100	0	No	No	No	No	8	9
187	1x50	2x50	Shared	100	50	Yes	No	No	Yes	9	9
188	1x52	8x54	Shared	100	0	No	No	Yes	No	6	7
189	1x53	2x47	Shared	100	100	Yes	No	No	No	9	9
190	1x53	8x50	Shared	100	50	Yes	No	Yes	Yes	9	9
191	1x56	8x53	Shared	100	50	No	No	No	No	7	4
192	1x57	2x44	Shared	100	100	No	No	No	No	7	7
193	1x60	I1x50	Shared	100	100	No	No	Yes	No	6	7
194	I1x48	I1x51	Shared	100	100	No	No	No	No	6	7
195	2x40	I1x50	Shared	100	100	Yes	No	Yes	No	8	7
196	8x49	I1x50	Shared	100	50	No	No	Yes	No	6	7
197	2x38	2x39	Shared	100	100	No	No	No	No	7	8
198	2x45	4x46	Shared	100	0	No	No	No	No	9	7
199	2x45	4x50	Shared	100	0	No	No	No	No	9	9
200	2x46	2x50	Shared	100	100	Yes	Yes	No	Yes	9	9
201	2x46	3x42	Shared	100	100	Yes	Yes	No	No	9	8
202	2x46	7x49	Shared	100	100	Yes	Yes	Yes	Yes	9	9
203	2x50	3x39	Shared	100	100	No	Yes	No	No	9	9
204	2x53	2x56	Shared	100	100	Yes	Yes	No	Yes	8	6
205	2x53	3x35	Shared	100	100	Yes	Yes	No	No	8	8
206	2x53	7x46	Shared	100	50	Yes	Yes	No	No	8	9
207	2x551	3x31	Shared	100	100	No	No	No	No	5	5
208	2x57	2x58	Shared	100	100	Yes	Yes	No	No	7	9
209	2x60	Lig	Shared	100	100	No	Yes	Yes	Yes	7	0
210	2x62	E1x51	Shared	100	100	No	No	No	No	4	2
211	2x63	E1x50	Shared	100	100	No	No	Yes	Yes	5	9
212	E1x49	E2.R253	Shared	100	100	No	No	No	No	5	5
213	3x25	E1x50	Shared	100	100	No	No	Yes	Yes	9	9
214	E1x50	E2x50	Shared	100	100	Yes	Yes	No	No	9	9
215	E1x51	E1x52	Shared	100	50	No	No	Yes	No	2	7
216	3x24	E1x52	Shared	100	100	No	No	Yes	No	6	7
217	3x25	E2x50	Shared	100	100	No	No	No	No	9	9
218	3x26	E2.D241	Shared	100	50	No	No	No	No	7	4
219	3x28	3x29	Shared	100	100	No	No	Yes	No	5	5
220	3x29	4x65	Shared	100	100	Yes	No	Yes	No	5	5
221	3x30	4x54	Shared	100	100	Yes	Yes	No	No	6	3
222	3x30	4x57	Shared	100	100	Yes	Yes	No	No	6	7
223	3x32	3x33	Shared	100	100	No	No	Yes	No	6	4
224	3x32	Lig	Shared	100	100	No	No	Yes	Yes	6	0
225	3x33	4x61	Shared	100	100	Yes	No	Yes	Yes	4	5
226	3x33	Lig	Shared	100	100	Yes	No	Yes	Yes	4	0
227	3x36	5x461	Shared	100	100	No	No	No	Yes	7	6
228	3x36	6x48	Shared	100	100	No	No	Yes	Yes	7	8
229	3x37	4x53	Shared	100	100	No	No	No	No	6	8
230	3x38	4x50	Shared	100	100	No	No	No	No	7	9
231	3x40	5x50	Shared	100	50	No	No	No	No	8	9
232	3x44	5x53	Shared	100	100	No	No	No	No	8	7
233	3x47	5x54	Shared	100	100	No	No	No	No	9	8
234	3x48	5x57	Shared	100	100	No	No	Yes	No	6	7
235	3x49	3x52	Shared	100	100	No	Yes	No	Yes	8	5
236	3x51	5x57	Shared	100	100	No	No	Yes	No	8	7
237	3x51	5x60	Shared	100	100	No	No	No	No	8	3
238	3x52	4x41	Shared	100	100	No	Yes	Yes	Yes	5	5
239	3x54	5x61	Shared	100	100	No	No	No	No	9	8
240	4x38	4x39	Shared	100	50	No	Yes	No	No	6	1
241	4x41	4x45	Shared	100	100	Yes	Yes	No	No	5	6
242	4x52	4x56	Shared	100	0	No	No	No	No	4	5
243	4x56	5x42	Shared	100	100	No	No	Yes	Yes	5	4
244	4x56	5x46	Shared	100	100	No	No	Yes	Yes	5	5
245	4x59	4x60	Shared	100	100	No	No	No	No	4	8
246	4x60	5x35	Shared	100	100	No	No	Yes	Yes	8	3
247	4x61	4x65	Shared	100	100	Yes	Yes	Yes	No	5	5
248	4x61	5x35	Shared	100	100	Yes	Yes	Yes	Yes	5	3
249	4x61	5x39	Shared	100	100	Yes	Yes	No	Yes	5	7
250	4x65	E2x52	Shared	100	100	Yes	No	No	No	5	5
251	E2.D241	E2.H258	Shared	100	100	No	No	Yes	Yes	4	4
252	E2.M245	E2.Y247	Shared	100	100	No	Yes	No	No	1	2
253	E2.H258	E2.P259	Shared	100	100	Yes	Yes	No	No	4	6
254	5x32	E2.Q261	Shared	100	100	Yes	No	No	Yes	4	2
255	5x33	E2.Q261	Shared	100	100	No	No	No	Yes	1	2
256	5x35	5x39	Shared	100	100	Yes	Yes	No	Yes	3	7
257	5x35	5x42	Shared	100	100	Yes	Yes	Yes	Yes	3	4
258	5x39	5x43	Shared	100	100	No	Yes	No	No	7	6
259	5x40	6x59	Shared	100	100	No	No	No	No	5	5
260	5x42	5x46	Shared	100	100	Yes	Yes	Yes	Yes	4	5
261	5x43	Lig	Shared	100	100	No	No	Yes	Yes	6	0
262	5x44	5x47	Shared	100	100	Yes	Yes	Yes	Yes	6	8
263	5x44	5x48	Shared	100	50	Yes	Yes	No	No	6	5
264	5x44	6x52	Shared	100	100	Yes	Yes	Yes	Yes	6	8
265	5x44	6x56	Shared	100	100	Yes	Yes	No	No	6	6
266	5x46	5x461	Shared	100	100	Yes	Yes	No	Yes	5	6
267	5x47	5x51	Shared	100	100	Yes	Yes	No	No	8	7
268	5x47	6x49	Shared	100	100	Yes	Yes	No	No	8	5
269	5x47	6x52	Shared	100	100	Yes	Yes	Yes	Yes	8	8
270	5x54	6x41	Shared	100	50	No	No	No	No	8	8
271	5x56	5x60	Shared	100	100	No	No	No	No	4	3
272	5x58	6x38	Shared	100	0	Yes	Yes	No	No	9	5
273	5x65	6x30	Shared	100	100	Yes	No	No	No	8	7
274	6x40	7x49	Shared	100	0	No	No	Yes	Yes	8	9
275	6x42	6x46	Shared	100	0	No	No	No	No	5	5
276	6x44	7x45	Shared	100	100	Yes	No	Yes	No	9	9
277	6x47	7x45	Shared	100	100	No	No	Yes	No	8	9
278	6x48	6x52	Shared	100	100	Yes	Yes	Yes	Yes	8	8
279	6x48	7x41	Shared	100	100	Yes	Yes	No	No	8	8
280	6x48	7x45	Shared	100	100	Yes	Yes	Yes	No	8	9
281	6x48	Lig	Shared	100	100	Yes	Yes	Yes	Yes	8	0
282	6x50	7x40	Shared	100	100	No	No	No	No	9	7
283	6x51	Lig	Shared	100	100	No	No	Yes	Yes	6	0
284	6x52	Lig	Shared	100	100	Yes	Yes	Yes	Yes	8	0
285	6x53	6x57	Shared	100	100	No	No	No	No	6	5
286	6x54	7x34	Shared	100	100	No	No	No	No	5	4
287	6x55	Lig	Shared	100	100	No	No	Yes	Yes	6	0
288	6x60	6x61	Shared	100	100	No	No	No	No	4	3
289	6x62	E3.Q352	Shared	100	100	Yes	Yes	No	No	2	1
290	6x62	7x27	Shared	100	100	Yes	Yes	No	No	2	3
291	E3.N351	E3.N353	Shared	100	100	No	No	No	No	1	1
292	7x23	E3.Q352	Shared	100	100	Yes	No	No	No	5	1
293	E3.D354	E3.P355	Shared	100	50	No	Yes	No	No	1	1
294	7x25	E3.N356	Shared	100	50	No	No	No	No	4	3
295	7x31	7x35	Shared	100	100	No	No	Yes	Yes	3	3
296	7x53	8x50	Shared	100	100	No	No	Yes	Yes	9	9
297	7x54	8x51	Shared	100	50	Yes	No	No	No	7	8
298	7x54	8x54	Shared	100	50	Yes	No	Yes	No	7	7
299	8x47	8x50	Shared	100	100	No	No	Yes	Yes	8	9
300	2x40	I1x52	Shared	100	100	Yes	No	No	No	8	8
301	2x63	Lig	Shared	100	100	No	No	Yes	Yes	5	0
302	3x54	5x65	Shared	100	100	No	No	Yes	No	9	8
303	E2.K248	E2.Y247	Shared	100	100	No	No	No	No	1	2
304	E2.H258	E2.V260	Shared	100	100	Yes	Yes	No	No	4	3
305	5x56	5x57	Shared	100	100	No	No	Yes	No	4	7
306	6x62	7x23	Shared	100	100	Yes	Yes	Yes	No	2	5
307	4x39	4x42	Shared	100	100	No	No	No	No	1	7
308	3x24	3x27	Shared	33.3333	100	No	No	No	No	6	5
309	5x34	5x38	Shared	66.6667	50	No	No	No	No	1	4
310	3x30	4x62	Shared	66.6667	50	Yes	Yes	No	No	6	4
311	2x42	3x46	Shared	33.3333	100	No	No	No	No	7	9
312	1x50	2x51	Shared	33.3333	100	Yes	No	No	No	9	7
313	1x45	7x47	Shared	33.3333	100	No	No	No	No	5	8
314	5x51	6x45	Shared	33.3333	0	No	No	No	No	7	6
315	1x60	I1x49	Shared	66.6667	100	No	No	No	No	6	5
316	6x62	7x26	Shared	33.3333	50	Yes	Yes	No	No	2	2
317	2x49	3x38	Shared	66.6667	0	No	No	No	No	8	7
318	3x30	3x31	Shared	66.6667	50	Yes	Yes	No	No	6	5
319	E2.I254	E2.M245	Shared	33.3333	100	No	No	No	Yes	4	1
320	6x54	7x33	Shared	33.3333	100	No	No	No	No	5	5
321	1x39	2x57	Shared	33.3333	0	No	No	Yes	Yes	7	7
322	5x29	5x32	Shared	0	100	No	No	Yes	No	3	4
323	2x52	3x35	Shared	33.3333	50	No	No	No	No	7	8
324	1x32	1x33	Shared	33.3333	100	Yes	No	No	No	6	3
325	6x57	7x30	Shared	33.3333	100	No	No	No	No	5	3
326	6x36	7x56	Shared	33.3333	100	No	No	No	No	8	7
327	1x46	7x47	Shared	0	0	No	No	No	No	8	8
328	3x53	I2x52	Shared	33.3333	0	No	No	No	No	8	5
329	8x50	8x54	Shared	0	50	Yes	Yes	Yes	No	9	7
330	1x48	1x49	Shared	0	0	No	No	No	No	5	8
331	6x43	7x48	Shared	0	100	No	No	No	No	6	6
332	E2.I242	E2.R253	Shared	0	100	No	No	No	No	5	5
333	4x51	4x55	Shared	0	0	No	No	No	No	4	4
334	6x49	6x53	Shared	33.3333	0	No	No	No	No	5	6
335	E3.D354	E3.N351	Shared	33.3333	100	No	Yes	No	No	1	1
336	E2.T244	E2.Y251	Shared	33.3333	100	No	No	No	No	1	5
337	E2.D246	E2.G249	Shared	33.3333	0	No	No	No	No	1	3
338	3x21	3x23	Shared	0	0	No	No	No	No	8	1
339	4x48	4x52	Shared	0	0	No	No	No	No	3	4
340	5x33	5x37	Shared	0	50	No	No	No	No	1	4
341	I2x56	I2x57	Shared	0	0	No	No	No	No	3	6
342	4x38	4x43	Shared	0	0	No	Yes	No	No	6	3
343	4x40	4x43	Shared	0	50	No	No	No	No	3	3
344	1x36	1x37	Shared	0	0	Yes	No	No	No	6	6
345	E2.L252	E2.S250	Shared	0	100	No	No	No	No	3	1
346	6x25	6x26	Shared	0	100	No	No	Yes	No	3	4
347	1x22	1x26	etb_on	0	100	No	No	No	No	4	5
348	1x24	Lig	etb_on	0	100	No	No	Yes	Yes	4	0
349	1x27	2x64	etb_on	0	100	No	No	No	No	5	4
350	1x29	1x33	etb_on	0	100	No	No	No	No	3	3
351	1x32	2x64	etb_on	0	100	Yes	No	No	No	6	4
352	1x39	7x39	etb_on	0	100	No	No	No	No	7	5
353	1x56	8x50	etb_on	0	100	No	No	Yes	Yes	7	9
354	2x39	I1x52	etb_on	0	100	No	No	No	No	8	8
355	2x38	4x39	etb_on	0	100	No	No	No	No	7	1
356	2x42	3x45	etb_on	0	100	No	No	No	No	7	7
357	2x42	3x49	etb_on	0	100	No	No	No	Yes	7	8
358	2x43	3x46	etb_on	0	100	No	No	No	No	8	9
359	2x50	7x46	etb_on	0	100	No	Yes	No	No	9	9
360	2x53	3x36	etb_on	0	100	Yes	Yes	No	No	8	7
361	2x53	6x48	etb_on	0	100	Yes	Yes	Yes	Yes	8	8
362	2x551	3x28	etb_on	0	100	No	No	No	No	5	5
363	2x56	2x60	etb_on	0	100	No	Yes	No	Yes	6	7
364	2x59	2x60	etb_on	0	100	No	No	No	Yes	6	7
365	2x60	7x38	etb_on	0	100	No	Yes	No	No	7	6
366	2x63	E1.E165	etb_on	0	100	No	No	No	No	5	4
367	2x64	7x35	etb_on	0	100	No	No	Yes	Yes	4	3
368	E1.E165	Lig	etb_on	0	100	No	No	Yes	Yes	4	0
369	E1x49	E1x51	etb_on	0	100	No	No	No	No	5	2
370	E1x50	Lig	etb_on	0	100	Yes	Yes	Yes	Yes	9	0
371	3x27	3x31	etb_on	0	100	No	No	No	No	5	5
372	3x40	5x461	etb_on	0	100	No	No	No	Yes	8	6
373	3x46	3x50	etb_on	0	100	No	No	Yes	No	9	9
374	3x47	5x58	etb_on	0	100	No	No	Yes	Yes	9	9
375	3x49	4x41	etb_on	0	100	No	Yes	Yes	Yes	8	5
376	3x50	5x58	etb_on	0	100	Yes	No	Yes	Yes	9	9
377	3x51	5x64	etb_on	0	100	No	No	Yes	No	8	5
378	3x55	5x64	etb_on	0	100	No	No	Yes	No	7	5
379	I2x50	I2x51	etb_on	0	100	No	No	No	No	8	5
380	4x40	4x44	etb_on	0	100	No	No	No	No	3	3
381	4x45	4x49	etb_on	0	100	No	No	No	No	6	7
382	4x61	E2x52	etb_on	0	100	Yes	Yes	No	No	5	5
383	E2.I243	E2.I254	etb_on	0	100	No	No	No	No	1	4
384	E2.L252	E2.M245	etb_on	0	100	No	No	No	Yes	3	1
385	E2.M245	Lig	etb_on	0	100	No	Yes	Yes	Yes	1	0
386	E2.Y247	Lig	etb_on	0	100	No	No	Yes	Yes	2	0
387	E2.R253	E2.Y251	etb_on	0	100	No	No	No	No	5	5
388	E2.I254	Lig	etb_on	0	100	No	No	Yes	Yes	4	0
389	E2x51	Lig	etb_on	0	100	No	No	Yes	Yes	4	0
390	5x39	E2x52	etb_on	0	100	No	Yes	No	No	7	5
391	E2.P259	Lig	etb_on	0	100	No	No	Yes	Yes	6	0
392	5x36	E2.Q261	etb_on	0	100	No	No	No	Yes	4	2
393	5x40	5x41	etb_on	0	100	No	No	No	No	5	5
394	5x40	6x56	etb_on	0	100	No	No	No	No	5	6
395	5x43	5x461	etb_on	0	100	No	No	No	Yes	6	6
396	5x461	6x52	etb_on	0	100	No	Yes	Yes	Yes	6	8
397	5x51	6x44	etb_on	0	100	No	No	Yes	No	7	9
398	5x58	6x37	etb_on	0	100	Yes	Yes	No	No	9	8
399	5x65	6x33	etb_on	0	100	Yes	No	No	No	8	8
400	6x28	6x31	etb_on	0	100	No	No	No	No	4	5
401	6x28	6x32	etb_on	0	100	No	No	No	No	4	7
402	6x48	6x51	etb_on	0	100	Yes	Yes	No	No	8	6
403	6x51	7x38	etb_on	0	100	No	No	No	No	6	6
404	6x58	Lig	etb_on	0	100	No	No	Yes	Yes	4	0
405	6x62	Lig	etb_on	0	100	Yes	Yes	Yes	Yes	2	0
406	E3.Q352	Lig	etb_on	0	100	No	No	Yes	Yes	1	0
407	E3.D354	E3.N353	etb_on	0	100	No	Yes	No	No	1	1
408	E3.D354	E3.N356	etb_on	0	100	No	Yes	No	No	1	3
409	7x26	E3.N356	etb_on	0	100	No	No	No	No	2	3
410	7x23	Lig	etb_on	0	100	Yes	No	Yes	Yes	5	0
411	7x27	Lig	etb_on	0	100	No	No	Yes	Yes	3	0
412	7x31	Lig	etb_on	0	100	No	No	Yes	Yes	3	0
413	7x34	Lig	etb_on	0	100	No	No	Yes	Yes	4	0
414	7x35	Lig	etb_on	0	100	Yes	Yes	Yes	Yes	3	0
415	7x43	7x48	etb_on	0	100	No	No	No	No	6	6
416	Lig	Lig	etb_on	0	100	Yes	Yes	Yes	Yes	0	0
417	1x25	Lig	etb_on	0	100	No	No	Yes	Yes	4	0
418	1x27	7x35	etb_on	0	100	No	No	Yes	Yes	5	3
419	1x55	1x58	etb_on	0	100	No	No	No	No	3	2
420	1x59	1x60	etb_on	0	100	No	No	No	No	4	6
421	2x56	3x32	etb_on	0	100	No	Yes	No	No	6	6
422	2x56	7x38	etb_on	0	100	No	Yes	No	No	6	6
423	3x52	3x56	etb_on	0	100	No	Yes	No	No	5	7
424	E2.H258	E2.Q261	etb_on	0	100	Yes	Yes	No	Yes	4	2
425	7x29	7x33	etb_on	0	100	No	No	No	No	3	5
426	1x57	2x40	etb_on	0	50	No	No	Yes	No	7	8
427	3x48	4x41	etb_on	0	50	No	No	Yes	Yes	6	5
428	2x46	3x43	etb_on	0	50	Yes	Yes	No	No	9	8
429	5x49	5x50	etb_on	0	50	No	No	No	No	6	9
430	3x52	I2x52	etb_on	0	50	No	Yes	No	No	5	5
431	2x57	7x42	etb_on	0	50	Yes	Yes	No	No	7	7
432	2x41	4x38	etb_on	0	50	No	No	No	Yes	6	6
433	6x50	7x37	etb_on	0	0	No	No	No	No	9	7
434	E2.K262	E2.V260	etb_on	0	50	No	No	No	No	1	3
435	5x58	5x61	etb_on	0	50	Yes	Yes	No	No	9	8
436	1x47	2x54	etb_on	0	50	No	No	No	No	7	6
437	3x37	5x461	etb_on	0	50	No	No	No	Yes	6	6
438	3x49	4x42	etb_on	0	50	No	Yes	No	No	8	7
439	2x43	7x53	etb_on	0	50	No	No	No	No	8	9
440	3x44	5x50	etb_on	0	50	No	No	No	No	8	9
441	7x49	7x53	etb_on	0	50	Yes	Yes	No	No	9	9
442	6x24	6x25	etb_on	0	50	No	No	No	No	2	3
443	1x30	1x31	etb_on	0	50	No	No	Yes	Yes	5	4
444	5x59	6x38	etb_on	0	0	No	No	No	No	4	5
445	6x26	I3.L311	etb_on	0	50	Yes	No	No	No	4	4
446	1x23	1x26	etb_on	0	50	No	No	No	No	4	5
447	2x45	3x42	etb_on	0	0	No	No	No	No	9	8
448	7x49	7x50	etb_on	0	0	Yes	Yes	No	No	9	9
449	3x41	5x46	etb_on	0	50	No	No	Yes	Yes	6	5
450	5x66	6x30	etb_on	0	50	No	No	No	No	5	7
451	6x47	7x43	etb_on	0	50	No	No	No	No	8	6
452	2x62	2x65	etb_on	0	0	No	No	No	No	4	4
453	1x25	7x28	etb_on	0	50	No	No	No	No	4	3
454	7x24	7x25	etb_on	0	50	No	No	No	No	8	4
455	7x48	7x51	etb_on	0	50	No	No	No	No	6	7
456	3x26	4x63	etb_on	0	50	No	No	No	No	7	5
457	6x32	6x33	etb_on	0	50	No	No	No	No	7	8
458	7x33	7x36	etb_on	0	0	No	No	No	No	5	5
459	8x52	8x55	etb_on	0	50	No	No	No	No	4	4
460	1x54	2x51	etb_on	0	50	No	No	No	No	7	7
461	6x61	7x26	etb_on	0	0	No	No	No	No	3	2
462	2x48	2x51	etb_on	0	50	No	No	No	No	6	7
463	6x57	6x61	etb_on	0	50	No	No	No	No	5	3
464	4x45	4x48	etb_on	0	0	No	No	No	No	6	3
465	6x25	6x29	etb_on	0	50	No	No	No	No	3	5
466	5x34	5x37	etb_on	0	50	No	No	No	No	1	4
467	5x29	5x31	etb_on	0	0	No	No	No	No	3	3
468	1x28	1x31	etb_on	0	0	No	No	Yes	Yes	3	4
469	E2.G249	E2.S250	etb_on	0	0	No	No	No	No	3	1
470	5x42	5x45	etb_on	0	0	Yes	Yes	No	No	4	4
471	6x27	6x30	etb_on	0	0	No	No	No	No	4	7
472	7x36	7x37	etb_on	0	0	No	No	No	No	5	7
473	4x64	E2.K262	etb_on	0	0	No	No	No	No	5	1
474	3x34	4x54	etb_on	0	0	No	No	No	No	6	3
475	5x62	6x34	etb_on	0	0	No	No	No	No	5	7
476	3x22	E2.I242	etb_on	0	0	No	No	No	No	3	5
477	7x56	8x47	etb_on	0	0	No	No	No	No	7	8
478	1x36	2x61	etb_on	0	50	Yes	No	No	No	6	7
479	2x65	2x66	etb_on	0	0	No	No	No	No	4	5
480	6x40	7x52	etb_on	0	0	No	No	No	No	8	7
481	8x52	8x53	etb_on	0	0	No	No	No	No	4	4
482	3x21	E1x52	etb_on	0	0	No	No	Yes	No	8	7
483	1x50	1x51	etb_on	0	0	Yes	No	No	No	9	4
484	6x28	6x29	etb_on	0	0	No	No	No	No	4	5
485	4x38	I1x51	etb_on	0	0	No	Yes	No	No	6	7
486	5x62	6x38	etb_on	0	0	No	No	No	No	5	5
487	1x40	1x44	etb_on	0	0	No	No	No	No	4	5
488	6x39	6x43	etb_on	0	0	No	No	No	No	5	6
489	5x55	6x41	etb_on	0	0	No	No	No	No	5	8
490	6x35	6x39	etb_on	0	0	No	No	No	No	5	5
491	4x51	4x52	etb_on	0	0	No	No	No	No	4	4
492	4x46	4x47	etb_on	0	0	No	No	No	No	7	3
493	5x30	5x33	etb_on	0	0	No	No	No	No	4	1
494	2x52	2x55	etb_on	0	0	No	No	No	No	7	5
495	7x55	7x56	etb_on	0	0	No	No	No	No	6	7
496	8x48	8x51	etb_on	0	0	No	No	No	No	5	8
497	1x52	1x55	etb_on	0	0	No	No	No	No	6	3
498	I2x52	I2x53	etb_on	0	0	No	No	No	No	5	6

Orange: nodes, hubs and links specific of etb_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of etb_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	etb_off Avg Int. Strength	etb_on Avg Int. Strength	etb_off Num Of Links	etb_on Num Of Links	ConSurf
1	1x32	etb_off	0	0	4	3	6
2	1x35	etb_off	66.6667	0	4	3	5
3	1x36	etb_off	0	0	4	2	6
4	1x50	etb_off	0	0	4	3	9
5	1x53	etb_off	66.6667	0	6	2	9
6	I1x50	etb_off	33.3333	50	4	3	7
7	2x40	etb_off	0	0	4	3	8
8	E1x52	etb_off	100	0	5	3	7
9	3x29	etb_off	33.3333	50	4	2	5
10	3x33	etb_off	66.6667	100	4	3	4
11	3x50	etb_off	66.6667	0	4	2	9
12	I2x54	etb_off	0	0	4	0	4
13	4x65	etb_off	66.6667	0	4	3	5
14	5x32	etb_off	33.3333	0	5	2	4
15	5x57	etb_off	33.3333	0	5	3	7
16	5x64	etb_off	0	0	4	2	5
17	5x65	etb_off	33.3333	50	4	3	8
18	6x26	etb_off	0	0	4	2	4
19	6x44	etb_off	100	0	4	2	9
20	7x23	etb_off	33.3333	0	4	3	5
21	7x45	etb_off	33.3333	0	4	3	9
22	7x54	etb_off	0	0	4	2	7
23	8x54	etb_off	0	0	4	3	7
24	1x31	Shared	33.3333	0	4	5	4
25	2x46	Shared	33.3333	50	4	4	9
26	2x53	Shared	100	100	6	5	8
27	2x57	Shared	33.3333	0	4	4	7
28	E1x50	Shared	100	100	7	4	9
29	3x30	Shared	33.3333	0	4	4	6
30	4x41	Shared	0	0	4	4	5
31	4x61	Shared	100	100	5	5	5
32	E2.H258	Shared	0	50	4	4	4
33	5x35	Shared	66.6667	100	5	4	3
34	5x42	Shared	0	50	4	4	4
35	5x44	Shared	66.6667	0	5	4	6
36	5x46	Shared	100	50	4	4	5
37	5x47	Shared	66.6667	0	4	4	8
38	5x58	Shared	0	50	4	5	9
39	6x48	Shared	100	100	6	7	8
40	6x52	Shared	66.6667	100	4	5	8
41	6x62	Shared	33.3333	50	5	5	2
42	7x35	Shared	100	50	4	5	3
43	7x49	Shared	0	0	4	4	9
44	8x50	Shared	100	50	6	5	9
45	Lig	Shared	100	100	15	28	0
46	2x50	etb_on	33.3333	0	3	4	9
47	2x56	etb_on	33.3333	100	2	4	6
48	2x60	etb_on	0	100	2	4	7
49	3x49	etb_on	33.3333	0	3	4	8
50	3x52	etb_on	0	0	3	4	5
51	4x38	etb_on	0	0	2	4	6
52	E2.M245	etb_on	0	50	3	4	1
53	E2.Q261	etb_on	0	0	3	4	2
54	5x39	etb_on	33.3333	50	3	4	7
55	5x461	etb_on	0	100	3	6	6
56	E3.D354	etb_on	0	50	3	4	1

Orange: nodes, hubs and links specific of etb_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of etb_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	etb_off Recurrence	etb_on Recurrence	etb_off Hub1?	etb_on Hub1?	etb_off Hub2?	etb_on Hub2?	ConSurf1	ConSurf2
1	6x62	7x27	etb_off	16.3187	0.117019	Yes	Yes	No	No	2	3
2	6x62	7x23	etb_off	16.8115	0.109705	Yes	Yes	Yes	No	2	5
3	7x27	7x31	etb_off	24.7339	0	No	No	No	No	3	3
4	7x31	7x35	etb_off	28.2737	0.182842	No	No	Yes	Yes	3	3
5	1x36	2x64	etb_off	11.3343	0	Yes	No	No	No	6	4
6	1x35	2x64	etb_off	40.3641	0	Yes	No	No	No	5	4
7	2x53	2x57	etb_off	10.2283	0	Yes	Yes	Yes	Yes	8	7
8	2x53	Lig	etb_off	28.6725	0	Yes	Yes	Yes	Yes	8	0
9	2x60	Lig	etb_off	51.7436	6.37753	No	Yes	Yes	Yes	7	0
10	2x60	2x64	etb_off	50.743	0	No	Yes	No	No	7	4
11	7x45	7x49	etb_off	100	0	Yes	No	Yes	Yes	9	9
12	5x47	6x49	etb_off	19.6479	6.88949	Yes	Yes	No	No	8	5
13	6x49	6x53	etb_off	14.1406	4.79046	No	No	No	No	5	6
14	6x53	6x57	etb_off	12.7751	2.71338	No	No	No	No	6	5
15	6x57	7x30	etb_off	11.4284	2.8304	No	No	No	No	5	3
16	6x40	7x53	etb_off	75.1984	0	No	No	No	No	8	9
17	6x40	7x49	etb_off	75.9057	4.93674	No	No	Yes	Yes	8	9
18	1x54	2x48	etb_off	10.0026	0	No	No	No	No	7	6
19	2x48	4x50	etb_off	11.4208	0	No	No	No	No	6	9
20	3x38	4x50	etb_off	23.8461	4.90748	No	No	No	No	7	9
21	3x38	4x53	etb_off	26.5245	0	No	No	No	No	7	8
22	3x41	4x53	etb_off	29.1728	0	No	No	No	No	6	8
23	3x41	4x49	etb_off	30.4856	0	No	No	No	No	6	7
24	3x42	4x49	etb_off	31.791	0	No	No	No	No	8	7
25	2x40	8x50	etb_off	48.8395	0	Yes	No	Yes	Yes	8	9
26	2x39	3x50	etb_off	13.1513	0	No	No	Yes	No	8	9
27	2x40	3x50	etb_off	17.9588	0	Yes	No	Yes	No	8	9
28	2x45	4x50	etb_off	11.5525	7.34294	No	No	No	No	9	9
29	2x45	4x46	etb_off	10.1343	4.90748	No	No	No	No	9	7
30	2x56	3x31	etb_off	11.6804	0	No	Yes	No	No	6	5
31	3x29	Lig	etb_off	13.6967	0	Yes	No	Yes	Yes	5	0
32	2x63	Lig	etb_off	49.1404	2.18679	No	No	Yes	Yes	5	0
33	2x63	E1x50	etb_off	48.1247	0.0219411	No	No	Yes	Yes	5	9
34	E1x50	E2.I242	etb_off	33.9578	0	Yes	Yes	No	No	9	5
35	E2.I242	E2.R253	etb_off	32.8932	5.08301	No	No	No	No	5	5
36	E2.I254	E2x51	etb_off	11.3719	0	No	No	No	No	4	4
37	E2.I254	E2.M245	etb_off	12.7412	0.0950779	No	No	No	Yes	4	1
38	E2.M245	E2.Y247	etb_off	16.5369	0.0950779	No	Yes	No	No	1	2
39	E2.L252	E2.Y247	etb_off	21.4761	0	No	No	No	No	3	2
40	E1x49	E2.L252	etb_off	24.1432	0	No	No	No	No	5	3
41	3x29	4x61	etb_off	12.1356	0	Yes	No	Yes	Yes	5	5
42	4x65	Lig	etb_off	13.9187	0	Yes	No	Yes	Yes	5	0
43	3x36	Lig	etb_off	27.1978	0	No	No	Yes	Yes	7	0
44	3x48	3x52	etb_off	22.7965	0	No	No	No	Yes	6	5
45	4x41	4x44	etb_off	31.381	0	Yes	Yes	No	No	5	3
46	4x44	4x48	etb_off	32.3778	0	No	No	No	No	3	3
47	5x42	5x461	etb_off	20.3137	0	Yes	Yes	No	Yes	4	6
48	2x39	3x49	etb_off	11.4396	0	No	No	No	Yes	8	8
49	5x65	6x30	etb_off	15.1902	6.48724	Yes	No	No	No	8	7
50	5x68	6x30	etb_off	22.0743	0	No	No	No	No	5	7
51	5x64	5x68	etb_off	31.4374	0	Yes	No	No	No	5	5
52	5x64	I2x54	etb_off	34.5145	0	Yes	No	Yes	No	5	4
53	I1x52	I2x54	etb_off	36.3277	0	No	No	Yes	No	8	4
54	5x35	5x39	etb_off	10.2434	7.694	Yes	Yes	No	Yes	3	7
55	5x32	5x35	etb_off	36.798	0	Yes	No	Yes	Yes	4	3
56	5x32	E2.Q261	etb_off	16.4278	7.75982	Yes	No	No	Yes	4	2
57	5x58	6x34	etb_off	10.2472	0	Yes	Yes	No	No	9	7
58	5x65	6x34	etb_off	11.4961	0	Yes	No	No	No	8	7
59	8x47	8x50	etb_off	14.0579	9.43465	No	No	Yes	Yes	8	9
60	7x23	E3.D354	etb_off	11.4622	0	Yes	No	No	Yes	5	1
61	7x54	8x54	etb_off	10.0816	7.34294	Yes	No	Yes	No	7	7
62	3x36	6x48	etb_off	12.177	6.26051	No	No	Yes	Yes	7	8
63	1x35	7x35	Shared	30.3766	53.8945	Yes	No	Yes	Yes	5	3
64	1x50	2x50	Shared	10.4653	12.2065	Yes	No	No	Yes	9	9
65	2x46	7x49	Shared	42.3353	82.9591	Yes	Yes	Yes	Yes	9	9
66	6x48	7x45	Shared	98.721	23.316	Yes	Yes	Yes	No	8	9
67	6x48	6x52	Shared	20.468	13.9838	Yes	Yes	Yes	Yes	8	8
68	5x47	6x52	Shared	22.7401	12.9087	Yes	Yes	Yes	Yes	8	8
69	6x48	Lig	Shared	79.0016	75.8941	Yes	Yes	Yes	Yes	8	0
70	8x50	8x54	Shared	18.4328	16.5947	Yes	Yes	Yes	No	9	7
71	7x53	8x50	Shared	65.9557	40.5324	No	No	Yes	Yes	9	9
72	2x46	3x42	Shared	33.0888	16.9385	Yes	Yes	No	No	9	8
73	2x53	2x56	Shared	13.1099	14.7444	Yes	Yes	No	Yes	8	6
74	E1x49	E2.R253	Shared	25.4561	12.6088	No	No	No	No	5	5
75	3x33	4x61	Shared	12.2597	50.3035	Yes	No	Yes	Yes	4	5
76	3x33	Lig	Shared	11.955	40.2106	Yes	No	Yes	Yes	4	0
77	4x61	4x65	Shared	11.3795	56.5713	Yes	Yes	Yes	No	5	5
78	5x43	Lig	Shared	11.9889	48.7676	No	No	Yes	Yes	6	0
79	3x36	5x461	Shared	38.4757	18.1087	No	No	No	Yes	7	6
80	3x48	5x57	Shared	20.7614	20.6246	No	No	Yes	No	6	7
81	3x52	4x41	Shared	21.4799	10.2465	No	Yes	Yes	Yes	5	5
82	4x48	4x52	Shared	33.4199	94.5879	No	No	No	No	3	4
83	4x52	4x56	Shared	34.6199	99.5466	No	No	No	No	4	5
84	4x56	5x42	Shared	20.3702	17.7211	No	No	Yes	Yes	5	4
85	4x56	5x46	Shared	15.9199	83.6173	No	No	Yes	Yes	5	5
86	5x46	5x461	Shared	17.3193	92.9423	Yes	Yes	No	Yes	5	6
87	2x40	I1x52	Shared	37.5428	23.338	Yes	No	No	No	8	8
88	4x61	5x35	Shared	32.7916	22.0215	Yes	Yes	Yes	Yes	5	3
89	5x39	5x43	Shared	11.0973	13.7205	No	Yes	No	No	7	6
90	6x52	Lig	Shared	16.9244	51.7809	Yes	Yes	Yes	Yes	8	0
91	5x44	6x52	Shared	13.3017	12.894	Yes	Yes	Yes	Yes	6	8
92	6x62	Lig	etb_on	0	32.2899	Yes	Yes	Yes	Yes	2	0
93	6x62	7x26	etb_on	7.71546	30.6078	Yes	Yes	No	No	2	2
94	7x26	E3.N356	etb_on	0	20.4125	No	No	No	No	2	3
95	7x35	Lig	etb_on	0	66.1157	Yes	Yes	Yes	Yes	3	0
96	1x31	1x35	etb_on	6.4214	12.8648	Yes	Yes	Yes	No	4	5
97	1x35	7x39	etb_on	2.87778	39.8961	Yes	No	No	No	5	5
98	1x39	7x39	etb_on	0	35.113	No	No	No	No	7	5
99	1x42	7x42	etb_on	8.55058	10.3196	No	No	No	No	8	7
100	2x57	7x42	etb_on	0	12.8648	Yes	Yes	No	No	7	7
101	1x39	2x57	etb_on	2.98311	25.3712	No	No	Yes	Yes	7	7
102	2x50	7x46	etb_on	0	99.0273	No	Yes	No	No	9	9
103	2x53	7x46	etb_on	2.98311	100	Yes	Yes	No	No	8	9
104	2x53	6x48	etb_on	0	79.5583	Yes	Yes	Yes	Yes	8	8
105	7x49	7x53	etb_on	0	76.0477	Yes	Yes	No	No	9	9
106	2x46	2x50	etb_on	9.94621	92.3718	Yes	Yes	No	Yes	9	9
107	2x39	I1x52	etb_on	0	26.2488	No	No	No	No	8	8
108	2x38	2x39	etb_on	1.36553	29.145	No	No	No	No	7	8
109	2x38	4x39	etb_on	0	32.0266	No	No	No	No	7	1
110	4x39	4x42	etb_on	5.83456	54.0481	No	No	No	No	1	7
111	3x49	4x42	etb_on	0	56.7688	No	Yes	No	No	8	7
112	3x49	4x41	etb_on	0	66.5106	No	Yes	Yes	Yes	8	5
113	4x41	4x45	etb_on	5.9587	90.0607	Yes	Yes	No	No	5	6
114	4x45	4x48	etb_on	0	93.0154	No	No	No	No	6	3
115	5x43	5x461	etb_on	0	46.8441	No	No	No	Yes	6	6
116	5x461	6x52	etb_on	0	51.9491	No	Yes	Yes	Yes	6	8
117	2x40	I1x50	etb_on	1.76429	14.5177	Yes	No	Yes	No	8	7
118	4x38	4x39	etb_on	4.38626	20.3759	No	Yes	No	No	6	1
119	2x42	3x46	etb_on	1.20001	32.4362	No	No	No	No	7	9
120	2x43	3x46	etb_on	0	51.13	No	No	No	No	8	9
121	2x43	7x53	etb_on	0	52.3733	No	No	No	No	8	9
122	2x42	3x49	etb_on	0	33.9867	No	No	No	Yes	7	8
123	2x56	3x32	etb_on	0	12.5357	No	Yes	No	No	6	6
124	2x551	3x28	etb_on	0	52.1027	No	No	No	No	5	5
125	3x28	3x29	etb_on	2.95302	54.3334	No	No	Yes	No	5	5
126	3x29	4x65	etb_on	0.0827597	56.5421	Yes	No	Yes	No	5	5
127	2x551	3x31	etb_on	2.99063	49.8574	No	No	No	No	5	5
128	E1x51	E1x52	etb_on	0.0677124	24.5228	No	No	Yes	No	2	7
129	3x24	E1x52	etb_on	2.79502	31.3684	No	No	Yes	No	6	7
130	3x24	3x27	etb_on	1.39939	33.7307	No	No	No	No	6	5
131	3x27	3x31	etb_on	0	36.0784	No	No	No	No	5	5
132	E1x49	E1x51	etb_on	0	15.0881	No	No	No	No	5	2
133	3x30	3x31	etb_on	7.40699	12.6088	Yes	Yes	No	No	6	5
134	2x45	3x42	etb_on	0	14.5615	No	No	No	No	9	8
135	3x40	5x461	etb_on	0	16.741	No	No	No	Yes	8	6
136	3x40	5x50	etb_on	1.56491	13.4206	No	No	No	No	8	9
137	3x46	3x50	etb_on	0	50.5083	No	No	Yes	No	9	9
138	3x50	5x58	etb_on	0	48.8335	Yes	No	Yes	Yes	9	9
139	3x48	4x41	etb_on	0	23.1332	No	No	Yes	Yes	6	5
140	3x51	5x57	etb_on	4.19817	11.8335	No	No	Yes	No	8	7
141	3x54	5x61	etb_on	0	28.2381	No	No	No	No	9	8
142	5x58	5x61	etb_on	0	30.2567	Yes	Yes	No	No	9	8
143	3x54	5x65	etb_on	1.30158	26.2269	No	No	Yes	No	9	8
144	5x35	5x42	etb_on	8.99447	22.1751	Yes	Yes	Yes	Yes	3	4
145	E2.P259	Lig	etb_on	0	44.2258	No	No	Yes	Yes	6	0
146	E2.H258	E2.P259	etb_on	1.44453	42.2658	Yes	Yes	No	No	4	6
147	E2.M245	Lig	etb_on	0	12.3236	No	Yes	Yes	Yes	1	0
148	E2.L252	E2.M245	etb_on	0	10.3196	No	No	No	Yes	3	1
149	E2.H258	E2.Q261	etb_on	0	25.3712	Yes	Yes	No	Yes	4	2
150	5x33	E2.Q261	etb_on	8.22706	12.8648	No	No	No	Yes	1	2
151	5x65	6x33	etb_on	0	18.0282	Yes	No	No	No	8	8
152	6x28	6x32	etb_on	0	14.1081	No	No	No	No	4	7
153	6x32	6x33	etb_on	0	16.2291	No	No	No	No	7	8
154	7x43	7x48	etb_on	0	12.7551	No	No	No	No	6	6
155	6x47	7x43	etb_on	0	15.2637	No	No	No	No	8	6
156	6x47	7x45	etb_on	1.45206	17.7576	No	No	Yes	No	8	9
157	7x33	7x36	etb_on	0	10.3196	No	No	No	No	5	5
158	6x54	7x33	etb_on	1.44077	15.3953	No	No	No	No	5	5
159	6x54	7x34	etb_on	2.87778	17.9112	No	No	No	No	5	4
160	7x34	Lig	etb_on	0	20.4125	No	No	Yes	Yes	4	0
161	E3.D354	E3.N356	etb_on	0	10.3196	No	Yes	No	No	1	3
162	2x53	3x36	etb_on	0	12.6161	Yes	Yes	No	No	8	7
163	3x32	3x33	etb_on	1.2602	11.6946	No	No	Yes	No	6	4

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
1x23	1x24	Shared	4.06	4.06	0	0	2	1
1x24	7x27	etb_off	4.37667	0	0	1	1	1
1x27	7x31	etb_off	3.80667	0	0	1	2	1
1x28	7x35	etb_off	5.57333	0	0	0	2	1
1x31	1x35	Shared	5.64	3.625	4	0	2	2
1x31	7x35	etb_off	18.2267	0	4	0	2	1
1x32	E1.E165	etb_off	3.6	0	0	1	2	1
1x35	2x64	etb_off	3.66	0	4	0	2	2
1x35	7x35	Shared	5.03667	3.49	4	0	2	1
1x42	7x42	Shared	5.38333	4.04	0	0	2	1
2x53	2x56	Shared	8.67333	8.82	1	1	1	2
2x53	3x32	etb_off	5.77	0	1	1	1	1
2x53	3x35	Shared	5.11	9.065	1	1	1	2
2x53	7x46	Shared	5.11333	3.485	1	1	1	2
2x53	Lig	etb_off	11.43	0	1	1	1	0
2x59	E1x52	etb_off	12.14	0	0	0	2	2
2x59	3x28	etb_off	5.63333	0	0	0	2	2
2x60	Lig	Shared	5.92	7.085	0	1	1	0
2x63	E1x50	Shared	6.96	4.64	0	1	1	1
E1x50	E1x51	etb_off	3.6	0	2	1	1	2
E1x50	E1x52	etb_off	13.3633	0	2	1	1	2
3x25	E1x50	Shared	8.27333	4.57	2	1	2	1
E1x50	E2x50	Shared	8.70667	7.835	2	1	1	2
E1x51	E1x52	Shared	9.63	3.61	2	0	2	2
3x25	E2x50	Shared	7.28	5.46	2	1	2	2
3x28	3x29	Shared	3.53	4.415	0	0	2	1
3x29	4x61	etb_off	5.76333	0	1	0	1	2
3x29	4x65	Shared	15.41	7.945	1	0	1	1
3x29	Lig	etb_off	4.94667	0	1	0	1	0
3x32	3x33	Shared	8.13667	9.495	1	1	1	1
3x32	Lig	Shared	20.8633	6.57	1	1	1	0
3x33	4x61	Shared	11.7	8.775	1	1	1	2
3x33	5x43	etb_off	4.7	0	1	1	1	1
3x33	Lig	Shared	14.27	4.64	1	1	1	0
3x36	5x461	Shared	4.20667	6.94	1	1	1	2
3x36	6x48	Shared	6.95	8.585	1	1	1	1
3x36	Lig	etb_off	4.68333	0	1	1	1	0
4x61	4x65	Shared	7.77333	6.995	1	1	2	1
4x61	5x39	Shared	8.55	8.775	1	1	2	2
4x65	E2x52	Shared	7.71333	7.915	1	1	1	2
4x65	Lig	etb_off	4.31	0	1	1	1	0
E2.I242	E2x50	etb_off	5.45667	0	2	0	2	2
E2.I243	E2x51	etb_off	3.80667	0	0	0	2	1
E2.M245	E2.Y247	Shared	3.59	6.585	0	1	1	1
E2.L252	E2.Y247	etb_off	10.55	0	0	0	2	1
E2.H258	E2.P259	Shared	9.15	4.575	0	0	2	1
5x39	5x43	Shared	5.64	4.23	1	1	2	1
5x43	Lig	Shared	9.39667	6.83	1	1	1	0
5x44	5x47	Shared	6.07	5.895	1	1	2	2
5x44	6x52	Shared	8.29667	5.09	1	1	2	1
5x47	6x52	Shared	17.3467	8.485	1	1	2	1
6x44	6x48	etb_off	14.6967	0	1	0	2	1
6x44	7x45	Shared	6.04	8.46	1	0	2	2
6x48	6x52	Shared	6.34667	7.41	1	1	1	1
6x48	7x41	Shared	8.64667	11.02	1	1	1	2
6x48	7x45	Shared	6.78	7.91	1	1	1	2
6x48	Lig	Shared	13.2	7.03	1	1	1	0
6x51	7x37	etb_off	3.99	0	1	1	1	2
6x51	Lig	Shared	5.78333	20.505	1	1	1	0
6x52	Lig	Shared	4.93667	8.995	1	1	1	0
6x54	7x34	Shared	4.11667	8.835	0	0	2	1
6x55	Lig	Shared	9.92333	23.63	1	0	1	0
6x62	E3.Q352	Shared	10.52	6.2	7	1	1	1
6x62	7x27	Shared	9.76667	4.1	7	1	1	1
7x23	E3.Q352	Shared	5.45	12.265	7	1	1	1
7x31	7x35	Shared	7.42333	4.105	0	1	1	1
7x38	Lig	etb_off	8.03	0	0	1	1	0
2x53	2x57	etb_off	3.53333	0	1	1	1	2
2x63	Lig	Shared	5.05333	5.815	0	1	1	0
E1x50	E2.I242	etb_off	4.30667	0	2	1	1	2
E2.K248	E2.Y247	Shared	11.9433	14.33	0	0	2	1
6x51	6x55	etb_off	4.05	0	1	1	1	1
6x55	7x34	etb_off	9.13	0	1	0	1	1
6x62	7x23	Shared	5.48667	8.745	7	1	1	1
7x23	E3.D354	etb_off	3.97	0	7	1	1	2
1x22	1x23	etb_off	3.28667	0	0	0	2	2
7x23	7x24	etb_off	3.25	0	7	1	1	2
6x58	6x62	etb_off	3.18333	0	0	0	1	1
6x62	7x26	Shared	3.12667	2.345	7	1	1	2
1x27	7x28	etb_off	3.09667	0	0	1	2	2
E2.H258	E2.I243	etb_off	3.09333	0	0	0	2	2
E2.I254	E2.M245	Shared	2.91667	3.645	0	1	1	1
E2.I254	E2x51	etb_off	2.85333	0	0	1	1	1
E2.M245	NT.P88	etb_off	2.79667	0	0	1	1	2
2x60	2x64	etb_off	2.74667	0	0	1	1	2
7x42	Lig	etb_off	2.14	0	0	0	1	0
3x21	E1x50	etb_off	1.40667	0	0	0	2	1
7x27	7x31	etb_off	1.38333	0	0	1	1	1
1x22	1x25	etb_off	1.37	0	0	0	2	1
1x25	1x26	etb_off	1.36667	0	0	1	1	2
1x22	1x26	etb_on	0	6.37	0	0	2	2
1x24	Lig	etb_on	0	6.26	0	1	1	0
1x27	2x64	etb_on	0	4.28	0	1	2	2
1x32	2x64	etb_on	0	7.05	0	1	2	2
2x53	3x36	etb_on	0	8.995	1	1	1	1
2x53	6x48	etb_on	0	4.76	1	1	1	1
2x56	2x60	etb_on	0	7.405	0	1	2	1
2x59	2x60	etb_on	0	4.955	0	0	2	1
2x60	7x38	etb_on	0	8.5	0	1	1	1
2x63	E1.E165	etb_on	0	11.475	0	1	1	1
2x64	7x35	etb_on	0	12.895	0	1	2	1
E1.E165	Lig	etb_on	0	8.76	0	1	1	0
E1x50	Lig	etb_on	0	7.045	2	1	1	0
4x61	E2x52	etb_on	0	4.64	1	1	2	2
E2.I243	E2.I254	etb_on	0	4.415	0	0	2	1
E2.L252	E2.M245	etb_on	0	4.24	0	0	2	1
E2.M245	Lig	etb_on	0	9.48	0	1	1	0
E2.Y247	Lig	etb_on	0	25.16	0	1	1	0
E2.I254	Lig	etb_on	0	11.73	0	1	1	0
E2x51	Lig	etb_on	0	10.115	0	0	1	0
5x39	E2x52	etb_on	0	4.23	1	1	2	2
E2.P259	Lig	etb_on	0	5.345	0	1	1	0
5x43	5x461	etb_on	0	5.275	1	1	1	2
5x461	6x52	etb_on	0	4.9	1	0	2	1
6x48	6x51	etb_on	0	7.4	1	1	1	1
6x51	7x38	etb_on	0	4.28	1	1	1	1
6x58	Lig	etb_on	0	8.065	0	0	1	0
6x62	Lig	etb_on	0	3.915	7	1	1	0
E3.Q352	Lig	etb_on	0	5.175	7	1	1	0
7x23	Lig	etb_on	0	8.14	7	1	1	0
7x27	Lig	etb_on	0	12.285	0	1	1	0
7x31	Lig	etb_on	0	8.525	0	1	1	0
7x34	Lig	etb_on	0	14.57	0	1	1	0
7x35	Lig	etb_on	0	7.805	4	1	1	0
1x25	Lig	etb_on	0	4.47	0	1	1	0
1x27	7x35	etb_on	0	4.23	0	1	2	1
2x56	3x32	etb_on	0	7.18	0	1	2	1
2x56	7x38	etb_on	0	4.2	0	1	2	1
2x57	7x42	etb_on	0	3.095	1	0	2	1
1x23	1x26	etb_on	0	2.455	0	0	2	2
1x25	7x28	etb_on	0	2.32	0	1	1	2
1x28	1x31	etb_on	0	1.86	0	0	2	2
3x21	E1x52	etb_on	0	1.505	0	0	2	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	etb_off	5XPR-ET_B-Bosentan 6K1Q-ET_B-IRL2500 5X93-ET_B-K-8794
	etb_on	8HCX-ET_B-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ET_B-IRL1620-Gi1/&β;1/&γ;2

Network Difference
Value	etb_off	etb_on
I_min	3.44	3.615
Number of Linked Nodes	308	296
Number of Specific Nodes	15 (4.87%)	3 (1.01%)
Number of Shared Nodes	293 (95.13%)	293 (98.99%)
Number of Links	346	327
Number of Specific Links	171 (49.42%)	152 (46.48%)
Number of Shared Links	175 (50.58%)	175 (53.52%)
Number of Hubs	45	33
Number of Specific Hubs	23 (51.11%)	11 (33.33%)
Number of Shared Hubs	22 (48.89%)	22 (66.67%)
Average % Shared Neighbours (Jaccard)	37.41
Average % Shared Neighbours (Otsuka)	47.62
Average % Shared Neighbours (Overlap Coefficient)	56.57
Average % Shared Cliques (k3-6)	54.07
Graphlets Similarity	0.64306

Paths Difference
Value	etb_off	etb_on
Number Of Nodes in MetaPath	87	96
Specific Nodes in MetaPath	34 (39.08%)	43 (44.79%)
Shared Nodes in MetaPath	293 (95.13%)	293 (95.13%)
Number Of Links MetaPath	91	101
Specific Links in MetaPath	62 (68.13%)	72 (71.29%)
Shared Links in MetaPath	175 (50.58%)	175 (50.58%)
Number of Shortest Paths	67729	51476
Length Of Smallest Path	3	3
Average Path Length	13.5935	12.9574
Length of Longest Path	33	36
Minimum Path Strength	0.551667	0.8
Average Path Strength	5.83392	5.81014
Maximum Path Strength	17.0317	22.8325
Minimum Path Correlation	0.7	0.7
Average Path Correlation	0.931482	0.931492
Maximum Path Correlation	0.99	0.99
Minimum % Of Corr. Nodes	3.57143	3.125
Average % Of Corr. Nodes	49.5004	53.8556
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	43.6572	38.0346
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

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