psnGPCR

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Orange: nodes, hubs and links specific of ghrelin_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of ghrelin_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	ghrelin_off Int. Strength	ghrelin_on Int. Strength	ghrelin_off Hub1?	ghrelin_on Hub1?	ghrelin_off Hub2?	ghrelin_on Hub2?	ConSurf1	ConSurf2
1	1x31	7x32	ghrelin_off	100	0	No	Yes	No	No	3	1
2	1x35	7x35	ghrelin_off	100	0	No	No	No	No	4	4
3	1x36	2x61	ghrelin_off	100	0	No	No	No	No	6	7
4	1x51	2x51	ghrelin_off	100	0	No	No	No	No	3	7
5	1x52	8x58	ghrelin_off	100	0	No	No	No	No	6	7
6	1x53	7x53	ghrelin_off	100	0	No	No	Yes	Yes	9	9
7	1x54	2x44	ghrelin_off	100	0	No	No	No	No	7	6
8	1x54	2x48	ghrelin_off	100	0	No	No	No	No	7	6
9	1x56	8x53	ghrelin_off	100	0	No	No	No	No	8	6
10	1x57	2x44	ghrelin_off	100	0	No	No	No	No	7	6
11	1x60	I1x50	ghrelin_off	100	0	Yes	Yes	No	No	5	8
12	1x60	8x57	ghrelin_off	100	0	Yes	Yes	No	No	5	5
13	2x39	3x50	ghrelin_off	100	0	No	No	Yes	No	8	9
14	2x42	3x42	ghrelin_off	100	0	Yes	Yes	No	No	8	8
15	2x42	4x46	ghrelin_off	100	0	Yes	Yes	No	No	8	7
16	2x49	3x39	ghrelin_off	100	0	No	No	Yes	No	8	9
17	2x59	E1x50	ghrelin_off	100	0	No	No	Yes	No	5	7
18	2x60	2x63	ghrelin_off	100	0	Yes	Yes	Yes	No	6	5
19	2x61	7x38	ghrelin_off	100	0	No	No	Yes	Yes	7	5
20	2x63	3x28	ghrelin_off	100	0	Yes	No	Yes	Yes	5	4
21	2x63	3x29	ghrelin_off	100	0	Yes	No	Yes	Yes	5	4
22	3x30	3x34	ghrelin_off	100	0	Yes	Yes	No	No	6	5
23	3x33	4x61	ghrelin_off	100	0	No	No	No	Yes	4	4
24	3x36	6x48	ghrelin_off	100	0	No	No	Yes	Yes	7	8
25	3x39	6x44	ghrelin_off	100	0	Yes	No	Yes	No	9	9
26	3x40	5x50	ghrelin_off	100	0	No	No	No	No	8	9
27	3x40	6x44	ghrelin_off	100	0	No	No	Yes	No	8	9
28	3x41	5x46	ghrelin_off	100	0	No	No	No	No	6	6
29	3x46	6x37	ghrelin_off	100	0	No	Yes	No	No	8	8
30	3x49	I2x56	ghrelin_off	100	0	No	No	No	No	9	4
31	3x50	6x33	ghrelin_off	100	0	Yes	No	No	No	9	8
32	3x52	3x56	ghrelin_off	100	0	Yes	No	No	Yes	5	6
33	3x52	I2x52	ghrelin_off	100	0	Yes	No	No	No	5	5
34	3x52	I2x55	ghrelin_off	100	0	Yes	No	No	No	5	4
35	3x54	5x65	ghrelin_off	100	0	No	No	No	No	9	8
36	3x54	6x30	ghrelin_off	100	0	No	No	No	No	9	6
37	E2.H186	E2.P192	ghrelin_off	100	0	No	No	No	No	2	1
38	E2.E187	E2.T190	ghrelin_off	100	0	No	No	No	No	3	3
39	E2.E202	E2.R206	ghrelin_off	100	0	No	No	No	No	6	1
40	5x47	6x48	ghrelin_off	100	0	Yes	Yes	Yes	Yes	8	8
41	5x52	5x56	ghrelin_off	100	0	No	No	No	No	3	4
42	5x54	6x41	ghrelin_off	100	0	Yes	No	No	No	8	8
43	5x61	6x34	ghrelin_off	100	0	No	Yes	No	No	8	7
44	5x66	6x35	ghrelin_off	100	0	Yes	No	No	No	4	7
45	5x67	5x69	ghrelin_off	100	0	No	No	No	No	5	3
46	5x70	5x72	ghrelin_off	100	0	No	No	No	No	4	4
47	6x39	7x52	ghrelin_off	100	0	No	No	No	No	6	8
48	6x39	7x56	ghrelin_off	100	0	No	No	No	No	6	7
49	6x40	7x49	ghrelin_off	100	0	No	No	No	No	8	9
50	6x48	6x52	ghrelin_off	100	0	Yes	Yes	No	No	8	7
51	6x48	7x45	ghrelin_off	100	0	Yes	Yes	No	No	8	9
52	6x51	7x41	ghrelin_off	100	0	Yes	Yes	Yes	Yes	6	7
53	7x31	7x32	ghrelin_off	100	0	No	No	No	No	3	1
54	7x41	Lig	ghrelin_off	100	0	Yes	Yes	Yes	Yes	7	0
55	7x49	7x53	ghrelin_off	100	0	No	No	Yes	Yes	9	9
56	7x53	8x50	ghrelin_off	100	0	Yes	Yes	Yes	Yes	9	8
57	7x54	8x51	ghrelin_off	100	0	No	No	No	No	7	8
58	8x47	8x49	ghrelin_off	100	0	No	No	No	No	8	6
59	8x51	8x55	ghrelin_off	100	0	No	No	No	No	8	3
60	NT.F38	NT.Q36	ghrelin_off	100	0	No	No	No	No	0	0
61	2x66	NT.Q36	ghrelin_off	100	0	Yes	No	No	No	4	0
62	7x31	NT.L37	ghrelin_off	100	0	No	No	No	No	3	0
63	7x31	NT.F38	ghrelin_off	100	0	No	No	No	No	3	0
64	7x35	NT.F38	ghrelin_off	100	0	No	No	No	No	4	0
65	2x66	E2.N196	ghrelin_off	100	0	Yes	No	No	No	4	4
66	2x67	E1x49	ghrelin_off	100	0	No	No	Yes	No	3	4
67	E1x49	E1x50	ghrelin_off	100	0	Yes	No	Yes	No	4	7
68	3x50	6x27	ghrelin_off	100	0	Yes	No	No	No	9	1
69	3x50	6x30	ghrelin_off	100	0	Yes	No	No	No	9	6
70	5x40	6x55	ghrelin_off	100	0	No	No	Yes	Yes	5	6
71	5x64	5x67	ghrelin_off	100	0	No	No	No	No	5	5
72	6x27	6x30	ghrelin_off	100	0	No	No	No	No	1	6
73	6x48	Lig	ghrelin_off	100	0	Yes	Yes	Yes	Yes	8	0
74	6x58	7x30	ghrelin_off	100	0	Yes	No	No	No	4	4
75	7x54	8x54	ghrelin_off	100	0	No	No	No	No	7	6
76	8x58	8x60	ghrelin_off	100	0	No	No	No	No	7	0
77	1x53	7x50	ghrelin_off	50	0	No	No	No	No	9	9
78	4x40	4x43	ghrelin_off	50	0	No	No	No	No	4	3
79	3x53	I2x52	ghrelin_off	50	0	No	No	No	No	8	5
80	3x47	5x53	ghrelin_off	50	0	No	No	No	No	9	6
81	2x56	3x31	ghrelin_off	0	0	No	No	No	No	6	5
82	3x34	4x57	ghrelin_off	0	0	No	No	No	No	5	7
83	5x65	5x66	ghrelin_off	0	0	No	No	Yes	No	8	4
84	1x39	2x57	ghrelin_off	0	0	No	No	Yes	Yes	6	7
85	4x38	I2x57	ghrelin_off	50	0	No	No	No	No	7	7
86	4x64	E2.A204	ghrelin_off	50	0	No	No	No	No	4	4
87	2x37	2x39	ghrelin_off	50	0	No	No	No	No	7	8
88	5x52	5x57	ghrelin_off	50	0	No	No	No	No	3	7
89	3x30	4x59	ghrelin_off	0	0	Yes	Yes	No	No	6	4
90	5x35	E2.S207	ghrelin_off	50	0	No	No	No	No	4	3
91	6x36	7x53	ghrelin_off	50	0	No	No	Yes	Yes	8	9
92	4x64	4x65	ghrelin_off	50	0	No	No	No	No	4	4
93	6x26	6x27	ghrelin_off	50	0	No	No	No	No	5	1
94	3x44	5x49	ghrelin_off	50	0	No	No	No	No	7	5
95	6x29	6x33	ghrelin_off	50	0	No	No	No	No	5	8
96	6x63	E3.S294	ghrelin_off	50	0	No	No	No	No	1	0
97	E2.E197	E2.T195	ghrelin_off	50	0	No	No	No	Yes	4	3
98	5x62	5x66	ghrelin_off	0	0	No	No	Yes	No	5	4
99	2x54	7x47	ghrelin_off	0	0	Yes	Yes	No	No	6	7
100	5x69	I3.A247	ghrelin_off	50	0	No	No	No	No	3	2
101	6x53	6x54	ghrelin_off	50	0	No	No	No	No	7	4
102	5x34	5x37	ghrelin_off	50	0	No	No	No	No	2	4
103	6x31	6x32	ghrelin_off	50	0	No	Yes	No	No	5	7
104	2x66	NT.L35	ghrelin_off	50	0	Yes	No	No	No	4	0
105	7x30	7x33	ghrelin_off	50	0	No	No	No	No	4	5
106	6x58	7x29	ghrelin_off	50	0	Yes	No	No	No	4	0
107	E1x49	E1x51	ghrelin_off	50	0	Yes	No	No	No	4	3
108	3x27	4x62	ghrelin_off	0	0	No	No	No	No	5	5
109	7x27	E2.D194	ghrelin_off	50	0	No	No	No	No	0	5
110	1x45	7x51	ghrelin_off	0	0	No	No	No	No	6	6
111	7x37	Lig	ghrelin_off	50	0	No	No	Yes	Yes	7	0
112	3x48	5x57	ghrelin_off	0	0	No	No	No	No	7	7
113	6x58	E2x52	ghrelin_off	50	0	Yes	No	Yes	No	4	4
114	6x62	E2x52	ghrelin_off	50	0	No	No	Yes	No	1	4
115	E1.R107	E1x49	ghrelin_off	0	0	No	No	Yes	No	4	4
116	7x24	NT.L37	ghrelin_off	50	0	No	No	No	No	0	0
117	6x25	6x28	ghrelin_off	50	0	No	No	No	No	2	4
118	5x69	I3.V249	ghrelin_off	50	0	No	No	No	No	3	3
119	2x62	2x67	ghrelin_off	50	0	No	No	No	No	4	3
120	2x41	I1x51	ghrelin_off	50	0	No	No	No	No	5	7
121	6x56	6x57	ghrelin_off	0	0	No	No	No	No	5	4
122	5x40	5x44	ghrelin_off	0	0	No	No	No	No	5	4
123	6x43	7x48	ghrelin_off	0	0	No	No	No	No	6	7
124	5x51	5x55	ghrelin_off	0	0	No	No	No	No	6	5
125	6x59	6x60	ghrelin_off	0	0	No	No	No	No	4	4
126	4x63	5x35	ghrelin_off	0	0	No	No	No	No	4	4
127	1x38	1x42	ghrelin_off	0	0	No	No	No	No	5	7
128	I2x51	I2x54	ghrelin_off	0	0	No	No	No	No	7	4
129	6x24	6x26	ghrelin_off	0	0	No	No	No	No	2	5
130	1x33	2x65	ghrelin_off	0	0	No	No	Yes	No	4	4
131	5x54	6x42	ghrelin_off	0	0	Yes	No	No	No	8	5
132	1x28	1x30	ghrelin_off	0	0	No	No	No	No	4	2
133	E2.V205	E2x52	ghrelin_off	0	0	No	No	Yes	No	4	4
134	1x40	1x44	ghrelin_off	0	0	No	No	No	No	4	5
135	I3.V248	I3.V249	ghrelin_off	0	0	No	No	No	No	3	3
136	5x37	5x38	ghrelin_off	0	0	No	No	No	No	4	6
137	5x54	6x38	ghrelin_off	0	0	Yes	No	No	No	8	5
138	6x61	7x26	ghrelin_off	0	0	No	No	No	No	2	0
139	6x28	I3.A251	ghrelin_off	0	0	No	No	No	No	4	3
140	1x40	2x57	ghrelin_off	0	0	No	No	Yes	Yes	4	7
141	5x70	5x71	ghrelin_off	0	0	No	No	No	No	4	1
142	4x47	4x48	ghrelin_off	0	0	No	No	No	No	4	4
143	3x23	E1x52	ghrelin_off	0	0	No	No	No	Yes	4	6
144	1x32	2x65	Shared	100	100	No	No	Yes	No	5	4
145	1x43	1x47	Shared	100	100	No	Yes	No	Yes	7	6
146	1x43	2x54	Shared	100	100	No	Yes	Yes	Yes	7	6
147	1x43	2x57	Shared	100	100	No	Yes	Yes	Yes	7	7
148	1x46	2x54	Shared	100	100	No	No	Yes	Yes	8	6
149	1x47	2x51	Shared	100	0	No	Yes	No	No	6	7
150	1x47	2x54	Shared	100	100	No	Yes	Yes	Yes	6	6
151	1x49	7x50	Shared	100	100	No	No	No	No	8	9
152	1x50	2x47	Shared	100	100	No	No	No	No	9	9
153	1x50	2x50	Shared	100	100	No	No	No	Yes	9	9
154	1x50	7x50	Shared	100	100	No	No	No	No	9	9
155	1x53	8x50	Shared	100	33.3333	No	No	Yes	Yes	9	8
156	1x60	I1x49	Shared	100	100	Yes	Yes	No	No	5	6
157	1x60	8x53	Shared	100	100	Yes	Yes	No	No	5	6
158	1x60	8x56	Shared	100	66.6667	Yes	Yes	No	No	5	3
159	8x49	I1x50	Shared	100	100	No	No	No	No	6	8
160	2x37	2x40	Shared	100	100	No	No	No	No	7	8
161	2x38	3x49	Shared	100	100	No	No	No	No	7	9
162	2x38	4x42	Shared	100	100	No	No	No	No	7	7
163	2x39	3x46	Shared	100	0	No	No	No	Yes	8	8
164	2x41	4x42	Shared	100	0	No	No	No	No	5	7
165	2x42	3x45	Shared	100	100	Yes	Yes	No	No	8	7
166	2x42	3x46	Shared	100	100	Yes	Yes	No	Yes	8	8
167	2x42	3x49	Shared	100	100	Yes	Yes	No	No	8	9
168	2x42	4x42	Shared	100	100	Yes	Yes	No	No	8	7
169	2x42	4x45	Shared	100	100	Yes	Yes	No	No	8	6
170	2x43	7x53	Shared	100	100	No	No	Yes	Yes	8	9
171	2x45	4x46	Shared	100	100	No	No	No	No	9	7
172	2x46	3x42	Shared	100	100	No	No	No	No	9	8
173	2x46	3x43	Shared	100	100	No	No	No	Yes	9	8
174	2x48	2x52	Shared	100	100	No	No	No	Yes	6	7
175	2x50	3x39	Shared	100	100	No	Yes	Yes	No	9	9
176	2x50	7x46	Shared	100	100	No	Yes	No	No	9	9
177	2x52	3x35	Shared	100	100	No	Yes	No	No	7	8
178	2x53	3x35	Shared	100	100	No	No	No	No	7	8
179	2x53	7x41	Shared	100	100	No	No	Yes	Yes	7	7
180	2x54	7x42	Shared	100	100	Yes	Yes	Yes	Yes	6	7
181	2x54	7x46	Shared	100	100	Yes	Yes	No	No	6	9
182	2x57	7x42	Shared	100	100	Yes	Yes	Yes	Yes	7	7
183	2x59	3x28	Shared	100	100	No	No	Yes	Yes	5	4
184	2x60	7x38	Shared	100	100	Yes	Yes	Yes	Yes	6	5
185	2x60	7x42	Shared	100	100	Yes	Yes	Yes	Yes	6	7
186	2x60	Lig	Shared	100	100	Yes	Yes	Yes	Yes	6	0
187	2x63	Lig	Shared	100	100	Yes	No	Yes	Yes	5	0
188	2x64	7x38	Shared	100	100	No	No	Yes	Yes	4	5
189	2x65	2x66	Shared	100	33.3333	Yes	No	Yes	No	4	4
190	2x66	E1x49	Shared	100	100	Yes	No	Yes	No	4	4
191	E1x50	E1x52	Shared	100	100	Yes	No	No	Yes	7	6
192	E1x50	E2x50	Shared	100	100	Yes	No	No	No	7	9
193	E1x51	E2.W193	Shared	100	33.3333	No	No	No	No	3	4
194	3x24	E1x52	Shared	100	100	No	No	No	Yes	5	6
195	3x22	3x26	Shared	100	100	No	No	No	No	4	7
196	3x22	E2.V184	Shared	100	100	No	No	No	No	4	5
197	3x25	E2x50	Shared	100	100	No	No	No	No	9	9
198	3x26	4x62	Shared	100	100	No	No	No	No	7	5
199	3x28	3x29	Shared	100	100	Yes	Yes	Yes	Yes	4	4
200	3x29	4x65	Shared	100	100	Yes	Yes	No	No	4	4
201	3x29	Lig	Shared	100	100	Yes	Yes	Yes	Yes	4	0
202	3x30	4x54	Shared	100	100	Yes	Yes	No	No	6	4
203	3x30	4x62	Shared	100	100	Yes	Yes	No	No	6	5
204	3x32	Lig	Shared	100	33.3333	No	No	Yes	Yes	6	0
205	3x33	3x37	Shared	100	100	No	No	No	No	4	6
206	3x33	6x55	Shared	100	100	No	No	Yes	Yes	4	6
207	3x34	4x54	Shared	100	100	No	No	No	No	5	4
208	3x37	5x46	Shared	100	100	No	No	No	No	6	6
209	3x38	4x50	Shared	100	100	No	No	No	Yes	6	9
210	3x41	4x49	Shared	100	100	No	No	No	No	6	7
211	3x43	6x44	Shared	100	100	No	Yes	Yes	No	8	9
212	3x47	5x58	Shared	100	100	No	No	Yes	Yes	9	9
213	3x51	3x55	Shared	100	100	Yes	Yes	No	No	8	7
214	3x51	5x57	Shared	100	100	Yes	Yes	No	No	8	7
215	3x51	5x60	Shared	100	100	Yes	Yes	No	No	8	5
216	3x51	5x61	Shared	100	33.3333	Yes	Yes	No	Yes	8	8
217	4x50	4x54	Shared	100	100	No	Yes	No	No	9	4
218	4x56	5x46	Shared	100	100	No	No	No	No	5	6
219	4x59	4x60	Shared	100	100	No	No	No	No	4	7
220	4x60	5x39	Shared	100	100	No	No	No	Yes	7	5
221	E2.E185	E2x51	Shared	100	100	No	No	No	Yes	1	3
222	E2.E185	E2.T201	Shared	100	66.6667	No	No	No	No	1	3
223	E2.T190	E2.T195	Shared	100	100	No	No	No	Yes	3	3
224	E2.D191	E2.D194	Shared	100	100	No	No	No	No	6	5
225	E2.E197	E2x51	Shared	100	100	No	No	No	Yes	4	3
226	5x36	E2x52	Shared	100	100	No	No	Yes	No	3	4
227	E2.F203	E2.S207	Shared	100	100	No	No	No	No	6	3
228	5x39	5x42	Shared	100	33.3333	No	Yes	No	No	5	5
229	5x40	6x59	Shared	100	100	No	No	No	No	5	4
230	5x47	5x48	Shared	100	100	Yes	Yes	No	No	8	4
231	5x47	5x51	Shared	100	33.3333	Yes	Yes	No	No	8	6
232	5x47	6x52	Shared	100	100	Yes	Yes	No	No	8	7
233	5x51	6x45	Shared	100	33.3333	No	No	No	No	6	6
234	5x54	5x58	Shared	100	100	Yes	No	Yes	Yes	8	9
235	5x58	6x37	Shared	100	100	Yes	Yes	No	No	9	8
236	5x58	6x41	Shared	100	100	Yes	Yes	No	No	9	8
237	5x66	6x31	Shared	100	100	Yes	No	No	Yes	4	5
238	6x36	7x56	Shared	100	100	No	No	No	No	8	7
239	6x42	6x46	Shared	100	0	No	No	No	No	5	5
240	6x44	6x48	Shared	100	100	Yes	No	Yes	Yes	9	8
241	6x47	7x45	Shared	100	100	No	No	No	No	9	9
242	6x48	7x41	Shared	100	100	Yes	Yes	Yes	Yes	8	7
243	6x50	7x40	Shared	100	100	No	No	No	No	9	7
244	6x51	6x52	Shared	100	100	Yes	Yes	No	No	6	7
245	6x51	6x55	Shared	100	100	Yes	Yes	Yes	Yes	6	6
246	6x51	Lig	Shared	100	100	Yes	Yes	Yes	Yes	6	0
247	6x55	Lig	Shared	100	100	Yes	Yes	Yes	Yes	6	0
248	6x58	6x62	Shared	100	100	Yes	No	No	No	4	1
249	6x60	6x63	Shared	100	33.3333	No	No	No	No	4	1
250	7x38	7x42	Shared	100	100	Yes	Yes	Yes	Yes	5	7
251	7x38	Lig	Shared	100	100	Yes	Yes	Yes	Yes	5	0
252	7x41	7x42	Shared	100	100	Yes	Yes	Yes	Yes	7	7
253	7x48	7x52	Shared	100	66.6667	No	No	No	No	7	8
254	7x54	8x50	Shared	100	100	No	No	Yes	Yes	7	8
255	8x48	8x51	Shared	100	100	No	No	No	No	5	8
256	8x50	8x54	Shared	100	100	Yes	Yes	No	No	8	6
257	1x36	2x65	Shared	100	100	No	No	Yes	No	6	4
258	6x56	6x60	Shared	100	100	No	No	No	No	5	4
259	8x55	8x60	Shared	100	100	No	No	No	No	3	0
260	3x39	7x49	Shared	50	100	Yes	No	No	No	9	9
261	3x44	5x50	Shared	50	100	No	No	No	No	7	9
262	1x42	7x43	Shared	50	100	No	No	No	No	7	5
263	2x40	I1x50	Shared	50	100	No	No	No	No	8	8
264	7x28	7x32	Shared	50	100	No	No	No	No	0	1
265	2x57	2x58	Shared	0	66.6667	Yes	Yes	No	No	7	7
266	3x22	E2.G183	Shared	0	100	No	No	No	No	4	4
267	5x43	6x55	Shared	50	100	No	No	Yes	Yes	6	6
268	6x49	6x50	Shared	0	100	No	No	No	No	6	9
269	4x41	I2x56	Shared	50	100	No	No	No	No	5	4
270	3x55	5x64	Shared	0	100	No	No	No	No	7	5
271	E2.D191	E2.P192	Shared	50	33.3333	No	No	No	No	6	1
272	2x49	4x50	Shared	50	100	No	No	No	Yes	8	9
273	1x59	8x57	Shared	50	100	No	No	No	No	5	5
274	3x41	4x52	Shared	0	33.3333	No	No	No	No	6	4
275	6x49	6x53	Shared	0	33.3333	No	No	No	No	6	7
276	3x54	5x61	Shared	50	100	No	No	No	Yes	9	8
277	E2x51	E2x52	Shared	0	0	No	Yes	Yes	No	3	4
278	2x67	E2.E197	Shared	50	100	No	No	No	No	3	4
279	2x56	3x28	Shared	50	33.3333	No	No	Yes	Yes	6	4
280	E2.H186	E2.T195	Shared	50	33.3333	No	No	No	Yes	2	3
281	I1x48	I1x51	Shared	50	100	No	No	No	No	6	7
282	3x51	3x52	Shared	50	100	Yes	Yes	Yes	No	8	5
283	3x21	3x24	Shared	50	33.3333	No	No	No	No	8	5
284	5x47	6x49	Shared	50	100	Yes	Yes	No	No	8	6
285	1x35	7x39	Shared	0	0	No	No	No	No	4	5
286	1x42	7x47	Shared	50	0	No	No	No	No	7	7
287	6x63	E3.P292	Shared	0	100	No	No	No	No	1	2
288	7x26	E3.S294	Shared	50	100	No	No	No	No	0	0
289	8x48	8x52	Shared	0	33.3333	No	No	No	No	5	4
290	7x30	7x34	Shared	50	100	No	No	No	Yes	4	4
291	7x51	7x55	Shared	0	33.3333	No	No	No	No	6	6
292	5x45	5x49	Shared	50	0	No	No	No	No	5	5
293	2x41	4x39	Shared	0	33.3333	No	No	No	No	5	3
294	4x64	5x35	Shared	0	33.3333	No	No	No	No	4	4
295	1x48	1x49	Shared	0	0	No	No	No	No	3	8
296	1x29	1x30	Shared	0	0	No	No	No	No	2	2
297	3x38	4x53	Shared	0	0	No	No	No	No	6	8
298	1x28	1x31	Shared	0	33.3333	No	No	No	Yes	4	3
299	I2x50	I2x51	Shared	0	33.3333	No	No	No	No	8	7
300	4x48	4x52	Shared	0	0	No	No	No	No	4	4
301	7x36	7x40	Shared	0	33.3333	No	No	No	No	5	7
302	7x55	7x56	Shared	0	100	No	No	No	No	6	7
303	3x56	I2x50	Shared	0	0	No	Yes	No	No	6	8
304	4x39	4x43	Shared	0	0	No	No	No	No	3	3
305	2x52	2x55	Shared	0	0	No	Yes	No	No	7	5
306	1x55	8x57	Shared	0	33.3333	No	No	No	No	3	5
307	E2.E185	E2.E202	Shared	0	100	No	No	No	No	1	6
308	5x60	5x63	Shared	0	100	No	No	No	No	5	4
309	1x33	1x34	Shared	0	0	No	No	No	No	4	6
310	8x58	8x59	Shared	0	33.3333	No	No	No	No	7	5
311	5x38	5x42	Shared	0	100	No	No	No	No	6	5
312	5x59	5x60	Shared	0	0	No	No	No	No	4	5
313	4x44	4x48	Shared	0	33.3333	No	No	No	No	3	4
314	7x25	E3.S294	Shared	0	33.3333	No	No	No	No	0	0
315	4x38	4x41	Shared	0	66.6667	No	No	No	No	7	5
316	1x32	2x64	ghrelin_on	0	100	No	No	No	No	5	4
317	1x56	8x50	ghrelin_on	0	100	No	No	Yes	Yes	8	8
318	1x57	2x40	ghrelin_on	0	100	No	No	No	No	7	8
319	1x59	1x60	ghrelin_on	0	100	No	No	Yes	Yes	5	5
320	I1x49	I1x50	ghrelin_on	0	100	No	No	No	No	6	8
321	2x43	3x46	ghrelin_on	0	100	No	No	No	Yes	8	8
322	2x43	7x54	ghrelin_on	0	100	No	No	No	No	8	7
323	2x45	4x50	ghrelin_on	0	100	No	No	No	Yes	9	9
324	2x46	7x49	ghrelin_on	0	100	No	No	No	No	9	9
325	2x48	4x50	ghrelin_on	0	100	No	No	No	Yes	6	9
326	2x50	7x49	ghrelin_on	0	100	No	Yes	No	No	9	9
327	2x52	3x31	ghrelin_on	0	100	No	Yes	No	No	7	5
328	2x59	E1x52	ghrelin_on	0	100	No	No	No	Yes	5	6
329	2x60	3x28	ghrelin_on	0	100	Yes	Yes	Yes	Yes	6	4
330	2x63	2x67	ghrelin_on	0	100	Yes	No	No	No	5	3
331	2x63	E1x50	ghrelin_on	0	100	Yes	No	Yes	No	5	7
332	2x64	Lig	ghrelin_on	0	100	No	No	Yes	Yes	4	0
333	2x67	Lig	ghrelin_on	0	100	No	No	Yes	Yes	3	0
334	E1.R107	Lig	ghrelin_on	0	100	No	No	Yes	Yes	4	0
335	3x29	4x61	ghrelin_on	0	100	Yes	Yes	No	Yes	4	4
336	3x30	4x61	ghrelin_on	0	100	Yes	Yes	No	Yes	6	4
337	3x33	Lig	ghrelin_on	0	100	No	No	Yes	Yes	4	0
338	3x36	7x41	ghrelin_on	0	100	No	No	Yes	Yes	7	7
339	3x37	5x43	ghrelin_on	0	100	No	No	No	No	6	6
340	3x39	6x48	ghrelin_on	0	100	Yes	No	Yes	Yes	9	8
341	3x40	6x48	ghrelin_on	0	100	No	No	Yes	Yes	8	8
342	3x43	5x54	ghrelin_on	0	100	No	Yes	Yes	No	8	8
343	3x43	7x53	ghrelin_on	0	100	No	Yes	Yes	Yes	8	9
344	3x44	5x53	ghrelin_on	0	100	No	No	No	No	7	6
345	3x46	7x53	ghrelin_on	0	100	No	Yes	Yes	Yes	8	9
346	3x47	5x54	ghrelin_on	0	100	No	No	Yes	No	9	8
347	3x48	3x52	ghrelin_on	0	100	No	No	Yes	No	7	5
348	3x49	I2x57	ghrelin_on	0	100	No	No	No	No	9	7
349	3x50	5x58	ghrelin_on	0	100	Yes	No	Yes	Yes	9	9
350	3x50	7x53	ghrelin_on	0	100	Yes	No	Yes	Yes	9	9
351	3x51	3x56	ghrelin_on	0	100	Yes	Yes	No	Yes	8	6
352	3x55	3x56	ghrelin_on	0	100	No	No	No	Yes	7	6
353	3x56	I2x52	ghrelin_on	0	100	No	Yes	No	No	6	5
354	4x61	4x65	ghrelin_on	0	100	No	Yes	No	No	4	4
355	4x61	Lig	ghrelin_on	0	100	No	Yes	Yes	Yes	4	0
356	4x64	5x39	ghrelin_on	0	100	No	No	No	Yes	4	5
357	4x64	Lig	ghrelin_on	0	100	No	No	Yes	Yes	4	0
358	E2.N196	E2.V184	ghrelin_on	0	100	No	No	No	No	4	5
359	E2.H186	E2.N196	ghrelin_on	0	100	No	No	No	No	2	4
360	E2.E187	E2.T195	ghrelin_on	0	100	No	No	No	Yes	3	3
361	E2.D191	E2.W193	ghrelin_on	0	100	No	No	No	No	6	4
362	E2.D194	E2.W193	ghrelin_on	0	100	No	No	No	No	5	4
363	E2.E202	E2x51	ghrelin_on	0	100	No	No	No	Yes	6	3
364	5x35	E2.A204	ghrelin_on	0	100	No	No	No	No	4	4
365	6x62	E2.V205	ghrelin_on	0	100	No	No	No	No	1	4
366	5x39	Lig	ghrelin_on	0	100	No	Yes	Yes	Yes	5	0
367	5x44	5x48	ghrelin_on	0	100	No	No	No	No	4	4
368	5x49	5x50	ghrelin_on	0	100	No	No	No	No	5	9
369	5x50	6x44	ghrelin_on	0	100	No	No	Yes	No	9	9
370	5x58	6x40	ghrelin_on	0	100	Yes	Yes	No	No	9	8
371	5x63	5x67	ghrelin_on	0	100	No	No	No	No	4	5
372	5x64	5x68	ghrelin_on	0	100	No	No	No	No	5	5
373	5x65	6x30	ghrelin_on	0	100	No	No	No	No	8	6
374	5x69	6x30	ghrelin_on	0	100	No	No	No	No	3	6
375	6x27	6x29	ghrelin_on	0	100	No	No	No	No	1	5
376	6x32	6x35	ghrelin_on	0	100	No	No	No	No	7	7
377	6x40	7x52	ghrelin_on	0	100	No	No	No	No	8	8
378	6x40	7x53	ghrelin_on	0	100	No	No	Yes	Yes	8	9
379	6x48	6x51	ghrelin_on	0	100	Yes	Yes	Yes	Yes	8	6
380	6x54	7x33	ghrelin_on	0	100	No	No	No	No	4	5
381	6x54	7x34	ghrelin_on	0	100	No	No	No	Yes	4	4
382	6x58	Lig	ghrelin_on	0	100	Yes	No	Yes	Yes	4	0
383	6x61	6x62	ghrelin_on	0	100	No	No	No	No	2	1
384	6x61	Lig	ghrelin_on	0	100	No	No	Yes	Yes	2	0
385	7x25	7x29	ghrelin_on	0	100	No	No	No	No	0	0
386	7x31	Lig	ghrelin_on	0	100	No	No	Yes	Yes	3	0
387	7x34	Lig	ghrelin_on	0	100	No	Yes	Yes	Yes	4	0
388	7x43	7x48	ghrelin_on	0	100	No	No	No	No	5	7
389	Lig	Lig	ghrelin_on	0	100	Yes	Yes	Yes	Yes	0	0
390	2x57	2x61	ghrelin_on	0	100	Yes	Yes	No	No	7	7
391	E2.E202	E2.V205	ghrelin_on	0	100	No	No	No	No	6	4
392	5x40	5x41	ghrelin_on	0	100	No	No	No	No	5	4
393	5x43	6x52	ghrelin_on	0	100	No	No	No	No	6	7
394	6x31	6x35	ghrelin_on	0	100	No	Yes	No	No	5	7
395	4x45	4x49	ghrelin_on	0	66.6667	No	No	No	No	6	7
396	3x47	5x57	ghrelin_on	0	33.3333	No	No	No	No	9	7
397	5x36	6x59	ghrelin_on	0	66.6667	No	No	No	No	3	4
398	5x56	5x57	ghrelin_on	0	33.3333	No	No	No	No	4	7
399	7x34	7x37	ghrelin_on	0	33.3333	No	Yes	No	No	4	7
400	5x61	5x62	ghrelin_on	0	66.6667	No	Yes	No	No	8	5
401	5x69	6x31	ghrelin_on	0	33.3333	No	No	No	Yes	3	5
402	1x54	2x51	ghrelin_on	0	0	No	No	No	No	7	7
403	1x39	7x38	ghrelin_on	0	0	No	No	Yes	Yes	6	5
404	3x30	4x57	ghrelin_on	0	0	Yes	Yes	No	No	6	7
405	1x56	1x60	ghrelin_on	0	33.3333	No	No	Yes	Yes	8	5
406	8x47	8x50	ghrelin_on	0	0	No	No	Yes	Yes	8	8
407	6x57	7x30	ghrelin_on	0	33.3333	No	No	No	No	4	4
408	5x34	E2.S207	ghrelin_on	0	66.6667	No	No	No	No	2	3
409	5x65	6x33	ghrelin_on	0	0	No	No	No	No	8	8
410	5x37	5x41	ghrelin_on	0	33.3333	No	No	No	No	4	4
411	E2.D194	E2.T195	ghrelin_on	0	33.3333	No	No	No	Yes	5	3
412	5x61	5x65	ghrelin_on	0	0	No	Yes	No	No	8	8
413	6x57	7x29	ghrelin_on	0	0	No	No	No	No	4	0
414	3x23	3x26	ghrelin_on	0	33.3333	No	No	No	No	4	7
415	1x52	8x50	ghrelin_on	0	33.3333	No	No	Yes	Yes	6	8
416	7x24	7x28	ghrelin_on	0	33.3333	No	No	No	No	0	0
417	2x62	E1x52	ghrelin_on	0	33.3333	No	No	No	Yes	4	6
418	5x51	5x52	ghrelin_on	0	33.3333	No	No	No	No	6	3
419	6x47	6x48	ghrelin_on	0	33.3333	No	No	Yes	Yes	9	8
420	6x28	6x32	ghrelin_on	0	33.3333	No	No	No	No	4	7
421	7x56	8x51	ghrelin_on	0	33.3333	No	No	No	No	7	8
422	2x41	2x44	ghrelin_on	0	33.3333	No	No	No	No	5	6
423	1x47	1x51	ghrelin_on	0	0	No	Yes	No	No	6	3
424	6x46	7x40	ghrelin_on	0	0	No	No	No	No	5	7
425	1x31	7x35	ghrelin_on	0	0	No	Yes	No	No	3	4
426	5x62	6x34	ghrelin_on	0	0	No	No	No	No	5	7
427	7x28	7x29	ghrelin_on	0	33.3333	No	No	No	No	0	0
428	1x57	I1x51	ghrelin_on	0	0	No	No	No	No	7	7
429	8x54	8x55	ghrelin_on	0	33.3333	No	No	No	No	6	3
430	5x40	6x56	ghrelin_on	0	33.3333	No	No	No	No	5	5
431	4x43	4x47	ghrelin_on	0	0	No	No	No	No	3	4
432	5x35	E2.F203	ghrelin_on	0	0	No	No	No	No	4	6
433	5x55	6x41	ghrelin_on	0	0	No	No	No	No	5	8
434	1x35	1x38	ghrelin_on	0	0	No	No	No	No	4	5
435	1x28	7x31	ghrelin_on	0	33.3333	No	No	No	No	4	3
436	6x35	6x39	ghrelin_on	0	33.3333	No	No	No	No	7	6
437	1x31	1x35	ghrelin_on	0	33.3333	No	Yes	No	No	3	4
438	E2.F203	E2.R206	ghrelin_on	0	33.3333	No	No	No	No	6	1
439	6x29	6x31	ghrelin_on	0	33.3333	No	No	No	Yes	5	5
440	3x52	I2x53	ghrelin_on	0	0	Yes	No	No	No	5	6
441	1x45	1x46	ghrelin_on	0	0	No	No	No	No	6	8
442	4x38	4x40	ghrelin_on	0	0	No	No	No	No	7	4
443	6x43	7x52	ghrelin_on	0	0	No	No	No	No	6	8
444	3x27	3x31	ghrelin_on	0	0	No	No	No	No	5	5
445	7x48	7x51	ghrelin_on	0	0	No	No	No	No	7	6
446	I2x52	I2x56	ghrelin_on	0	0	No	No	No	No	5	4
447	E2.E187	E2.Q188	ghrelin_on	0	0	No	No	No	No	3	3
448	E3.G293	E3.P292	ghrelin_on	0	0	No	No	No	No	0	2
449	3x53	I2x53	ghrelin_on	0	0	No	No	No	No	8	6
450	4x60	4x63	ghrelin_on	0	0	No	No	No	No	7	4
451	E2.G189	E2.Q188	ghrelin_on	0	0	No	No	No	No	4	3
452	I2x55	I2x56	ghrelin_on	0	0	No	No	No	No	4	4
453	1x29	1x31	ghrelin_on	0	0	No	No	No	Yes	2	3
454	1x55	1x58	ghrelin_on	0	0	No	No	No	No	3	3
455	1x40	2x61	ghrelin_on	0	0	No	No	No	No	4	7
456	8x54	8x58	ghrelin_on	0	0	No	No	No	No	6	7
457	6x38	6x42	ghrelin_on	0	0	No	No	No	No	5	5
458	1x43	1x44	ghrelin_on	0	0	No	Yes	No	No	7	5

Orange: nodes, hubs and links specific of ghrelin_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of ghrelin_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	ghrelin_off Avg Int. Strength	ghrelin_on Avg Int. Strength	ghrelin_off Num Of Links	ghrelin_on Num Of Links	ConSurf
1	2x63	ghrelin_off	50	33.3333	4	3	5
2	2x65	ghrelin_off	0	0	4	3	4
3	2x66	ghrelin_off	0	0	5	2	4
4	E1x49	ghrelin_off	0	0	5	1	4
5	E1x50	ghrelin_off	50	66.6667	4	3	7
6	3x39	ghrelin_off	50	33.3333	4	3	9
7	3x50	ghrelin_off	50	0	4	2	9
8	3x52	ghrelin_off	0	0	4	3	5
9	E2x52	ghrelin_off	50	0	5	2	4
10	5x54	ghrelin_off	50	33.3333	4	3	8
11	5x66	ghrelin_off	0	0	4	1	4
12	6x44	ghrelin_off	100	100	4	3	9
13	6x58	ghrelin_off	0	33.3333	4	2	4
14	1x60	Shared	50	66.6667	5	5	5
15	2x42	Shared	100	100	7	5	8
16	2x54	Shared	100	100	6	5	6
17	2x57	Shared	0	66.6667	5	4	7
18	2x60	Shared	100	66.6667	4	4	6
19	3x28	Shared	100	66.6667	4	4	4
20	3x29	Shared	50	66.6667	4	4	4
21	3x30	Shared	0	0	4	4	6
22	3x51	Shared	100	100	5	6	8
23	5x47	Shared	100	33.3333	5	4	8
24	5x58	Shared	50	100	4	6	9
25	6x48	Shared	100	100	7	6	8
26	6x51	Shared	100	66.6667	4	4	6
27	6x55	Shared	0	66.6667	5	4	6
28	7x38	Shared	100	33.3333	5	5	5
29	7x41	Shared	50	100	5	4	7
30	7x42	Shared	100	100	5	5	7
31	7x53	Shared	100	66.6667	5	5	9
32	8x50	Shared	100	0	4	6	8
33	Lig	Shared	100	100	10	20	0
34	1x31	ghrelin_on	0	0	2	4	3
35	1x43	ghrelin_on	0	0	3	4	7
36	1x47	ghrelin_on	0	0	3	4	6
37	2x50	ghrelin_on	0	66.6667	3	4	9
38	2x52	ghrelin_on	0	0	3	4	7
39	E1x52	ghrelin_on	0	0	3	4	6
40	3x43	ghrelin_on	0	33.3333	2	4	8
41	3x46	ghrelin_on	0	0	3	4	8
42	3x56	ghrelin_on	0	0	2	4	6
43	4x50	ghrelin_on	50	66.6667	3	5	9
44	4x61	ghrelin_on	0	66.6667	1	4	4
45	E2.T195	ghrelin_on	0	0	3	4	3
46	E2x51	ghrelin_on	0	0	3	4	3
47	5x39	ghrelin_on	0	33.3333	2	4	5
48	5x61	ghrelin_on	50	0	3	4	8
49	6x31	ghrelin_on	0	0	2	4	5
50	7x34	ghrelin_on	0	33.3333	1	4	4

Orange: nodes, hubs and links specific of ghrelin_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of ghrelin_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	ghrelin_off Recurrence	ghrelin_on Recurrence	ghrelin_off Hub1?	ghrelin_on Hub1?	ghrelin_off Hub2?	ghrelin_on Hub2?	ConSurf1	ConSurf2
1	NT.F38	NT.Q36	ghrelin_off	13.8321	0	No	No	No	No	0	0
2	2x66	NT.Q36	ghrelin_off	14.7745	0	Yes	No	No	No	4	0
3	2x65	2x66	ghrelin_off	18.7478	2.5648	Yes	No	Yes	No	4	4
4	1x36	2x65	ghrelin_off	21.6417	1.38699	No	No	Yes	No	6	4
5	1x36	2x61	ghrelin_off	22.4747	0	No	No	No	No	6	7
6	2x61	7x38	ghrelin_off	23.1239	0	No	No	Yes	Yes	7	5
7	2x54	7x46	ghrelin_off	12.5142	6.84402	Yes	Yes	No	No	6	9
8	2x50	7x46	ghrelin_off	12.0684	6.33015	No	Yes	No	No	9	9
9	6x48	Lig	ghrelin_off	86.3283	0	Yes	Yes	Yes	Yes	8	0
10	3x39	6x44	ghrelin_off	58.5116	0	Yes	No	Yes	No	9	9
11	3x39	7x49	ghrelin_off	30.2648	3.00136	Yes	No	No	No	9	9
12	7x49	7x53	ghrelin_off	28.0044	0	No	No	Yes	Yes	9	9
13	7x53	8x50	ghrelin_off	13.7812	0	Yes	Yes	Yes	Yes	9	8
14	7x54	8x51	ghrelin_off	10.9577	0	No	No	No	No	7	8
15	2x46	3x42	ghrelin_off	81.6315	2.31924	No	No	No	No	9	8
16	2x42	3x42	ghrelin_off	80.9354	0	Yes	Yes	No	No	8	8
17	2x39	3x46	ghrelin_off	58.1088	1.60528	No	No	No	Yes	8	8
18	2x37	2x39	ghrelin_off	16.7729	0	No	No	No	No	7	8
19	2x37	2x40	ghrelin_off	15.5293	1.86448	No	No	No	No	7	8
20	2x40	I1x50	ghrelin_off	14.2779	9.24966	No	No	No	No	8	8
21	1x60	I1x50	ghrelin_off	10.4767	0	Yes	Yes	No	No	5	8
22	2x39	3x50	ghrelin_off	44.3276	0	No	No	Yes	No	8	9
23	2x49	3x39	ghrelin_off	26.4401	0	No	No	Yes	No	8	9
24	E1x49	E1x50	ghrelin_off	49.6969	0	Yes	No	Yes	No	4	7
25	2x59	E1x50	ghrelin_off	59.9703	0	No	No	Yes	No	5	7
26	2x59	3x28	ghrelin_off	61.5619	4.1246	No	No	Yes	Yes	5	4
27	2x63	3x28	ghrelin_off	34.1754	0	Yes	No	Yes	Yes	5	4
28	3x28	3x29	ghrelin_off	31.8016	4.15189	Yes	Yes	Yes	Yes	4	4
29	2x49	4x50	ghrelin_off	25.2591	2.09186	No	No	No	Yes	8	9
30	6x55	Lig	ghrelin_off	31.876	1.24602	Yes	Yes	Yes	Yes	6	0
31	3x33	6x55	ghrelin_off	16.6986	2.70123	No	No	Yes	Yes	4	6
32	3x33	3x37	ghrelin_off	13.9338	6.27558	No	No	No	No	4	6
33	3x37	5x46	ghrelin_off	12.4164	6.84402	No	No	No	No	6	6
34	3x46	6x37	ghrelin_off	11.7516	0	No	Yes	No	No	8	8
35	5x58	6x37	ghrelin_off	10.4767	1.70077	Yes	Yes	No	No	9	8
36	3x50	6x30	ghrelin_off	38.1917	0	Yes	No	No	No	9	6
37	3x54	6x30	ghrelin_off	37.4643	0	No	No	No	No	9	6
38	3x54	5x61	ghrelin_off	29.8189	1.90086	No	No	No	Yes	9	8
39	3x51	3x52	ghrelin_off	10.0231	7.63529	Yes	Yes	Yes	No	8	5
40	2x67	E1x49	ghrelin_off	46.3963	0	No	No	Yes	No	3	4
41	E2.E197	E2.T195	ghrelin_off	14.7785	0	No	No	No	Yes	4	3
42	5x40	6x55	ghrelin_off	17.5629	0	No	No	Yes	Yes	5	6
43	5x47	6x48	ghrelin_off	13.7187	0	Yes	Yes	Yes	Yes	8	8
44	6x36	7x53	ghrelin_off	11.7516	0	No	No	Yes	Yes	8	9
45	6x36	7x56	ghrelin_off	10.4767	1.25512	No	No	No	No	8	7
46	6x59	6x60	ghrelin_off	13.2768	0	No	No	No	No	4	4
47	2x63	Lig	ghrelin_off	30.6949	9.36335	Yes	No	Yes	Yes	5	0
48	3x29	Lig	ghrelin_off	38.0626	5.02501	Yes	Yes	Yes	Yes	4	0
49	2x50	3x39	ghrelin_off	14.0941	4.75671	No	Yes	Yes	No	9	9
50	2x54	7x42	Shared	19.1819	18.4038	Yes	Yes	Yes	Yes	6	7
51	2x57	7x42	Shared	10.637	11.5553	Yes	Yes	Yes	Yes	7	7
52	7x38	Lig	Shared	20.9808	14.2883	Yes	Yes	Yes	Yes	5	0
53	6x44	6x48	Shared	100	100	Yes	No	Yes	Yes	9	8
54	7x54	8x50	Shared	12.2874	42.0964	No	No	Yes	Yes	7	8
55	7x41	7x42	Shared	14.4695	20.7594	Yes	Yes	Yes	Yes	7	7
56	2x53	7x41	Shared	11.9158	16.4075	No	No	Yes	Yes	7	7
57	2x53	3x35	Shared	10.4532	14.3702	No	No	No	No	7	8
58	3x43	6x44	Shared	83.0003	97.5716	No	Yes	Yes	No	8	9
59	2x46	3x43	Shared	82.3198	11.5416	No	No	No	Yes	9	8
60	2x42	3x46	Shared	66.986	31.096	Yes	Yes	No	Yes	8	8
61	2x42	4x42	Shared	10.1873	12.5284	Yes	Yes	No	No	8	7
62	4x50	4x54	Shared	21.6691	10.7367	No	Yes	No	No	9	4
63	3x30	4x54	Shared	17.8992	13.3561	Yes	Yes	No	No	6	4
64	3x51	5x61	Shared	27.5116	28.3311	Yes	Yes	No	Yes	8	8
65	2x67	E2.E197	Shared	42.6968	22.0782	No	No	No	No	3	4
66	E2.E197	E2x51	Shared	26.7725	20.9459	No	No	No	Yes	4	3
67	E2x51	E2x52	Shared	17.0349	15.8754	No	Yes	Yes	No	3	4
68	5x40	6x59	Shared	14.7824	11.819	No	No	No	No	5	4
69	6x48	7x41	Shared	14.4617	26.0846	Yes	Yes	Yes	Yes	8	7
70	6x51	Lig	ghrelin_on	1.40393	83.8108	Yes	Yes	Yes	Yes	6	0
71	6x48	6x51	ghrelin_on	0	92.5284	Yes	Yes	Yes	Yes	8	6
72	3x43	7x53	ghrelin_on	0	69.6135	No	Yes	Yes	Yes	8	9
73	6x40	7x53	ghrelin_on	0	25.9845	No	No	Yes	Yes	8	9
74	6x40	7x52	ghrelin_on	0	18.3993	No	No	No	No	8	8
75	7x48	7x52	ghrelin_on	2.66317	15.6708	No	No	No	No	7	8
76	7x38	7x42	ghrelin_on	8.57612	14.4156	Yes	Yes	Yes	Yes	5	7
77	2x43	7x53	ghrelin_on	1.32963	43.0196	No	No	Yes	Yes	8	9
78	2x43	7x54	ghrelin_on	0	43.7108	No	No	No	No	8	7
79	1x56	8x50	ghrelin_on	0	27.9445	No	No	Yes	Yes	8	8
80	1x56	1x60	ghrelin_on	0	26.5075	No	No	Yes	Yes	8	5
81	1x60	I1x49	ghrelin_on	1.33354	14.6794	Yes	Yes	No	No	5	6
82	I1x49	I1x50	ghrelin_on	0	12.874	No	No	No	No	6	8
83	3x46	7x53	ghrelin_on	0	31.9372	No	Yes	Yes	Yes	8	9
84	2x42	4x45	ghrelin_on	1.33354	10.764	Yes	Yes	No	No	8	6
85	4x61	Lig	ghrelin_on	0	38.1583	No	Yes	Yes	Yes	4	0
86	3x30	4x61	ghrelin_on	0	37.2397	Yes	Yes	No	Yes	6	4
87	2x46	7x49	ghrelin_on	0	10.7958	No	No	No	No	9	9
88	2x52	3x35	ghrelin_on	8.98283	12.6057	No	Yes	No	No	7	8
89	2x60	Lig	ghrelin_on	3.20676	15.7117	Yes	Yes	Yes	Yes	6	0
90	2x67	Lig	ghrelin_on	0	22.5421	No	No	Yes	Yes	3	0
91	3x30	4x62	ghrelin_on	7.90348	24.0337	Yes	Yes	No	No	6	5
92	3x26	4x62	ghrelin_on	5.29897	22.7331	No	No	No	No	7	5
93	3x22	3x26	ghrelin_on	3.98498	20.1046	No	No	No	No	4	7
94	3x22	E2.V184	ghrelin_on	1.33354	17.4397	No	No	No	No	4	5
95	3x43	5x54	ghrelin_on	0	52.6648	No	Yes	Yes	No	8	8
96	3x47	5x54	ghrelin_on	0	47.6262	No	No	Yes	No	9	8
97	3x47	5x57	ghrelin_on	0	66.1255	No	No	No	No	9	7
98	3x51	5x57	ghrelin_on	5.29897	62.9604	Yes	Yes	No	No	8	7
99	3x50	7x53	ghrelin_on	0	10.1592	Yes	No	Yes	Yes	9	9
100	3x51	3x56	ghrelin_on	0	16.5211	Yes	Yes	No	Yes	8	6
101	3x56	I2x52	ghrelin_on	0	11.055	No	Yes	No	No	6	5
102	E2.N196	E2.V184	ghrelin_on	0	16.0937	No	No	No	No	4	5
103	E2.H186	E2.N196	ghrelin_on	0	14.7385	No	No	No	No	2	4
104	E2.H186	E2.T195	ghrelin_on	9.29178	13.3743	No	No	No	Yes	2	3
105	5x36	E2x52	ghrelin_on	2.02964	14.4566	No	No	Yes	No	3	4
106	5x36	6x59	ghrelin_on	0	13.256	No	No	No	No	3	4
107	6x51	6x52	ghrelin_on	2.36205	23.829	Yes	Yes	No	No	6	7
108	5x47	6x52	ghrelin_on	1.15756	20.3683	Yes	Yes	No	No	8	7
109	5x47	6x49	ghrelin_on	8.23198	11.8554	Yes	Yes	No	No	8	6
110	5x61	5x65	ghrelin_on	0	21.1096	No	Yes	No	No	8	8
111	5x65	6x30	ghrelin_on	0	17.799	No	No	No	No	8	6
112	5x69	6x30	ghrelin_on	0	15.9527	No	No	No	No	3	6
113	5x69	6x31	ghrelin_on	0	14.4293	No	No	No	Yes	3	5
114	7x48	7x51	ghrelin_on	0	10.0136	No	No	No	No	7	6
115	7x34	Lig	ghrelin_on	0	18.8358	No	Yes	Yes	Yes	4	0
116	7x30	7x34	ghrelin_on	2.02964	13.297	No	No	No	Yes	4	4
117	6x57	7x30	ghrelin_on	0	11.8554	No	No	No	No	4	4
118	6x57	7x29	ghrelin_on	0	10.4047	No	No	No	No	4	0
119	7x31	Lig	ghrelin_on	0	12.7058	No	No	Yes	Yes	3	0
120	1x28	1x31	ghrelin_on	3.50397	10.2774	No	No	No	Yes	4	3
121	1x28	7x31	ghrelin_on	0	11.4961	No	No	No	No	4	3
122	2x60	7x42	ghrelin_on	7.01185	15.4252	Yes	Yes	Yes	Yes	6	7
123	5x58	6x40	ghrelin_on	0	11.9827	Yes	Yes	No	No	9	8
124	3x47	5x58	ghrelin_on	2.66317	20.0637	No	No	Yes	Yes	9	9

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
2x53	7x41	Shared	6.28	5.44333	0	0	2	1
2x60	2x63	ghrelin_off	8.34	0	1	1	1	1
2x60	7x38	Shared	12.54	7.96	1	1	1	1
2x60	7x42	Shared	7.475	3.45	1	1	1	2
2x60	Lig	Shared	20.975	4.68667	1	1	1	0
2x61	7x38	ghrelin_off	4.26	0	0	0	2	1
2x63	3x28	ghrelin_off	4.275	0	1	1	1	2
2x63	3x29	ghrelin_off	5.255	0	1	1	1	1
2x63	Lig	Shared	16.375	5.88333	1	1	1	0
2x64	7x38	Shared	13.395	4.87	0	1	1	1
3x28	3x29	Shared	5.855	9.36667	1	0	2	1
3x29	4x65	Shared	4.3	9.07333	1	1	1	2
3x29	Lig	Shared	10.85	17.3333	1	1	1	0
3x32	Lig	Shared	6.525	1.78333	0	0	1	0
3x33	3x37	Shared	7.86	10.1033	0	1	1	2
3x33	4x61	ghrelin_off	6.835	0	0	1	1	1
3x33	6x55	Shared	5.815	10.47	0	1	1	1
3x36	6x48	ghrelin_off	7.88	0	0	0	2	1
3x39	6x44	ghrelin_off	6.825	0	0	2	2	2
3x40	6x44	ghrelin_off	5.245	0	0	0	2	2
4x60	5x39	Shared	8.385	5.03333	0	0	2	1
5x39	5x42	Shared	4.565	2.03	0	1	1	2
5x47	6x48	ghrelin_off	5.015	0	1	0	2	1
5x47	6x52	Shared	22.06	13.9533	1	0	2	2
6x44	6x48	Shared	7.515	15.3667	0	0	2	1
6x47	7x45	Shared	4.3	5.74	0	0	2	2
6x48	6x52	ghrelin_off	11.105	0	1	0	1	2
6x48	7x41	Shared	7.515	4.67667	1	0	1	1
6x48	7x45	ghrelin_off	4.94	0	1	0	1	2
6x51	6x52	Shared	10.18	5.66	1	1	1	2
6x51	6x55	Shared	9.085	11.76	1	1	1	1
6x51	7x41	ghrelin_off	6.43	0	1	1	1	1
6x51	Lig	Shared	5.05	4.67333	1	1	1	0
6x55	Lig	Shared	16.68	21.2367	1	1	1	0
6x58	6x62	Shared	4.285	7.50333	6	1	1	2
7x31	7x32	ghrelin_off	7.325	0	0	1	1	2
7x38	7x42	Shared	9.285	12.7233	1	1	1	2
7x38	Lig	Shared	4.635	10.82	1	1	1	0
7x41	7x42	Shared	8.765	8.94333	1	0	1	2
7x41	Lig	ghrelin_off	18.19	0	1	0	1	0
7x31	NT.L37	ghrelin_off	5.325	0	0	1	1	2
7x31	NT.F38	ghrelin_off	3.515	0	0	1	1	2
2x67	E1x49	ghrelin_off	13.21	0	0	1	1	2
E1x49	E1x50	ghrelin_off	12.16	0	0	0	2	2
5x40	6x55	ghrelin_off	5.885	0	0	0	2	1
6x48	Lig	ghrelin_off	9.73	0	1	0	1	0
6x58	7x30	ghrelin_off	3.965	0	6	1	1	2
5x43	6x55	Shared	3.295	4.83333	0	0	2	1
4x64	E2.A204	ghrelin_off	3.155	0	0	1	1	2
4x64	4x65	ghrelin_off	2.98	0	0	1	1	2
2x67	E2.E197	Shared	2.805	4.49	0	1	1	2
6x58	7x29	ghrelin_off	2.51	0	6	1	1	2
7x37	Lig	ghrelin_off	2.265	0	0	0	1	0
7x30	7x34	Shared	2.235	3.97333	0	0	2	1
6x58	E2x52	ghrelin_off	2.165	0	6	1	1	2
6x62	E2x52	ghrelin_off	2.165	0	6	0	2	2
E1.R107	E1x49	ghrelin_off	2.16	0	0	0	1	2
4x64	5x35	Shared	2.075	2.76667	0	1	1	2
2x62	2x67	ghrelin_off	1.895	0	0	0	2	1
6x61	7x26	ghrelin_off	0.775	0	0	1	1	2
1x32	2x64	ghrelin_on	0	3.23	0	0	2	1
2x60	3x28	ghrelin_on	0	6.37	1	1	1	2
2x63	2x67	ghrelin_on	0	3.77333	1	1	1	1
2x63	E1x50	ghrelin_on	0	7	1	1	1	2
2x64	Lig	ghrelin_on	0	8.72667	0	1	1	0
2x67	Lig	ghrelin_on	0	5.24333	0	1	1	0
E1.R107	Lig	ghrelin_on	0	5.61333	0	0	1	0
3x29	4x61	ghrelin_on	0	3.66	1	1	1	1
3x30	4x61	ghrelin_on	0	3.35	4	0	2	1
3x33	Lig	ghrelin_on	0	14.3867	0	1	1	0
3x36	7x41	ghrelin_on	0	6.92	0	0	2	1
3x37	5x43	ghrelin_on	0	5.93667	0	0	2	2
3x39	6x48	ghrelin_on	0	4.25333	0	2	2	1
3x40	6x48	ghrelin_on	0	4.90333	0	0	2	1
4x61	4x65	ghrelin_on	0	4.09667	0	1	1	2
4x61	Lig	ghrelin_on	0	4.39	0	1	1	0
4x64	5x39	ghrelin_on	0	4.71	0	1	1	1
4x64	Lig	ghrelin_on	0	5.20333	0	1	1	0
5x35	E2.A204	ghrelin_on	0	3.68	0	0	2	2
5x39	Lig	ghrelin_on	0	6.80667	0	1	1	0
6x48	6x51	ghrelin_on	0	7.68333	1	0	1	1
6x54	7x34	ghrelin_on	0	4.52333	0	0	2	1
6x58	Lig	ghrelin_on	0	14.7533	6	1	1	0
6x61	6x62	ghrelin_on	0	3.52	0	1	1	2
6x61	Lig	ghrelin_on	0	3.89667	0	1	1	0
7x31	Lig	ghrelin_on	0	7.38667	0	1	1	0
7x34	Lig	ghrelin_on	0	18.9033	0	1	1	0
5x43	6x52	ghrelin_on	0	4.18333	0	0	2	2
7x34	7x37	ghrelin_on	0	2.98	0	1	1	1
1x39	7x38	ghrelin_on	0	2.79	0	0	2	1
6x47	6x48	ghrelin_on	0	2.17667	0	0	2	1
1x28	7x31	ghrelin_on	0	1.58	0	0	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	ghrelin_off	6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
	ghrelin_on	7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2

Network Difference
Value	ghrelin_off	ghrelin_on
I_min	3.515	3.09
Number of Linked Nodes	295	286
Number of Specific Nodes	16 (5.42%)	7 (2.45%)
Number of Shared Nodes	279 (94.58%)	279 (97.55%)
Number of Links	315	315
Number of Specific Links	143 (45.40%)	143 (45.40%)
Number of Shared Links	172 (54.60%)	172 (54.60%)
Number of Hubs	33	37
Number of Specific Hubs	13 (39.39%)	17 (45.95%)
Number of Shared Hubs	20 (60.61%)	20 (54.05%)
Average % Shared Neighbours (Jaccard)	39.93
Average % Shared Neighbours (Otsuka)	49.43
Average % Shared Neighbours (Overlap Coefficient)	58.68
Average % Shared Cliques (k3-6)	78.57
Graphlets Similarity	0.588066

Paths Difference
Value	ghrelin_off	ghrelin_on
Number Of Nodes in MetaPath	68	73
Specific Nodes in MetaPath	31 (45.59%)	36 (49.32%)
Shared Nodes in MetaPath	279 (94.58%)	279 (94.58%)
Number Of Links MetaPath	69	75
Specific Links in MetaPath	49 (71.01%)	55 (73.33%)
Shared Links in MetaPath	172 (54.60%)	172 (54.60%)
Number of Shortest Paths	54220	54010
Length Of Smallest Path	3	3
Average Path Length	14.099	12.0615
Length of Longest Path	33	29
Minimum Path Strength	0.7	0.703333
Average Path Strength	6.464	6.08546
Maximum Path Strength	19.5825	16.5217
Minimum Path Correlation	0.7	0.706667
Average Path Correlation	0.92025	0.919249
Maximum Path Correlation	0.99	0.99
Minimum % Of Corr. Nodes	3.33333	3.84615
Average % Of Corr. Nodes	45.8883	47.3262
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	40.7687	43.6774
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

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