Orange: nodes, hubs and links specific of ghrelin_on_gp network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of ghrelin_off network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.


Index Hub Owner ghrelin_on_gp Avg Int. Strength ghrelin_off Avg Int. Strength ghrelin_on_gp Num Of Links ghrelin_off Num Of Links ConSurf
1G.S1.01 ghrelin_on_gp00406
2G.S1.02 ghrelin_on_gp66.66670405
3G.s1h1.04 ghrelin_on_gp00409
4G.H1.01 ghrelin_on_gp66.66670509
5G.S2.05 ghrelin_on_gp00403
6G.S2.06 ghrelin_on_gp00409
7G.S2.08 ghrelin_on_gp66.66670405
8G.S3.03 ghrelin_on_gp1000507
9G.S3.04 ghrelin_on_gp66.66670406
10G.S3.06 ghrelin_on_gp1000605
11G.S3.07 ghrelin_on_gp00509
12G.s3h2.03 ghrelin_on_gp66.66670609
13G.H2.04 ghrelin_on_gp66.66670509
14G.H2.06 ghrelin_on_gp1000709
15G.H2.07 ghrelin_on_gp1000609
16G.h2s4.01 ghrelin_on_gp1000509
17G.S4.02 ghrelin_on_gp00408
18G.S4.07 ghrelin_on_gp00408
19G.s4h3.04 ghrelin_on_gp66.66670508
20G.H3.09 ghrelin_on_gp1000709
21G.H3.13 ghrelin_on_gp1000605
22G.H3.17 ghrelin_on_gp1000605
23G.H3.18 ghrelin_on_gp66.66670409
24G.S5.02 ghrelin_on_gp00406
25G.S5.04 ghrelin_on_gp33.33330509
26G.S5.05 ghrelin_on_gp1000409
27G.S5.07 ghrelin_on_gp33.33330409
28G.s5hg.01 ghrelin_on_gp33.33330409
29G.HG.03 ghrelin_on_gp00406
30G.HG.04 ghrelin_on_gp66.66670409
31G.hgh4.01 ghrelin_on_gp00406
32G.hgh4.02 ghrelin_on_gp1000507
33G.hgh4.05 ghrelin_on_gp66.66670407
34G.hgh4.08 ghrelin_on_gp00403
35G.H4.03 ghrelin_on_gp66.66670504
36G.H4.10 ghrelin_on_gp66.66670406
37G.H4.12 ghrelin_on_gp00405
38G.H4.15 ghrelin_on_gp1000408
39G.S6.01 ghrelin_on_gp33.33330405
40G.S6.02 ghrelin_on_gp1000607
41G.S6.05 ghrelin_on_gp66.66670404
42G.H5.02 ghrelin_on_gp00504
43G.H5.03 ghrelin_on_gp1000408
44G.H5.05 ghrelin_on_gp33.33330405
45G.H5.08 ghrelin_on_gp1000508
46G.H5.23 ghrelin_on_gp33.33330404
47b.h2x5 ghrelin_on_gp33.33330405
48b.lhb1x3 ghrelin_on_gp66.66670502
49b.b1x4 ghrelin_on_gp66.66670407
50b.l1x3 ghrelin_on_gp1000609
51b.l1x6 ghrelin_on_gp33.33330409
52b.b2x1 ghrelin_on_gp66.66670608
53b.b2x5 ghrelin_on_gp1000607
54b.b3x3 ghrelin_on_gp33.33330408
55b.l3x1 ghrelin_on_gp33.33330409
56b.l3x2 ghrelin_on_gp1000509
57b.b4x3 ghrelin_on_gp00407
58b.b4x4 ghrelin_on_gp00408
59b.b4x6 ghrelin_on_gp1000609
60b.l4x2 ghrelin_on_gp66.66670404
61b.b5x2 ghrelin_on_gp00407
62b.b5x3 ghrelin_on_gp1000609
63b.b5x5 ghrelin_on_gp1000405
64b.b5x7 ghrelin_on_gp66.66670407
65b.l5x1 ghrelin_on_gp66.66670408
66b.l5x5 ghrelin_on_gp1000709
67b.b6x5 ghrelin_on_gp1000606
68b.b7x1 ghrelin_on_gp66.66670404
69b.b7x2 ghrelin_on_gp66.66670408
70b.b8x3 ghrelin_on_gp1000406
71b.b8x4 ghrelin_on_gp1000606
72b.l8x5 ghrelin_on_gp00403
73b.l9x3 ghrelin_on_gp1000509
74b.l9x6 ghrelin_on_gp1000808
75b.b10x5 ghrelin_on_gp33.33330509
76b.b11x3 ghrelin_on_gp00405
77b.b11x4 ghrelin_on_gp66.66670609
78b.l11x2 ghrelin_on_gp1000509
79b.b12x5 ghrelin_on_gp66.66670406
80b.b12x6 ghrelin_on_gp1000608
81b.b13x7 ghrelin_on_gp1000507
82b.l13x3 ghrelin_on_gp1000509
83b.l13x7 ghrelin_on_gp66.66670409
84b.b14x3 ghrelin_on_gp33.33330405
85b.b15x1 ghrelin_on_gp33.33330509
86b.b15x2 ghrelin_on_gp33.33330406
87b.l15x2 ghrelin_on_gp66.66670409
88b.b16x4 ghrelin_on_gp1000406
89b.b16x5 ghrelin_on_gp33.33330505
90b.b16x6 ghrelin_on_gp1000608
91b.b17x3 ghrelin_on_gp33.33330405
92b.b17x5 ghrelin_on_gp1000507
93b.b17x7 ghrelin_on_gp1000408
94b.l17x3 ghrelin_on_gp1000609
95b.l17x6 ghrelin_on_gp33.33330409
96b.b18x3 ghrelin_on_gp1000408
97b.l18x1 ghrelin_on_gp1000606
98b.l18x2 ghrelin_on_gp66.66670407
99b.l18x3 ghrelin_on_gp00405
100b.b19x2 ghrelin_on_gp1000506
101b.b19x4 ghrelin_on_gp1000408
102b.l19x1 ghrelin_on_gp33.33330409
103b.l19x2 ghrelin_on_gp1000509
104b.b20x4 ghrelin_on_gp1000508
105b.b20x6 ghrelin_on_gp1000606
106b.b20x7 ghrelin_on_gp33.33330509
107b.l20x2 ghrelin_on_gp66.66670409
108b.b21x1 ghrelin_on_gp1000607
109b.b21x2 ghrelin_on_gp00506
110b.b21x5 ghrelin_on_gp33.33330404
111b.b21x7 ghrelin_on_gp1000505
112b.l21x2 ghrelin_on_gp00404
113b.l21x5 ghrelin_on_gp66.66670404
114b.b22x5 ghrelin_on_gp33.33330507
115b.l22x5 ghrelin_on_gp1000609
116b.b23x1 ghrelin_on_gp66.66670405
117b.b23x6 ghrelin_on_gp1000707
118b.l24x2 ghrelin_on_gp66.66670406
119b.l24x3 ghrelin_on_gp66.66670405
120b.l25x3 ghrelin_on_gp1000509
121b.l25x4 ghrelin_on_gp33.33330405
122b.l25x6 ghrelin_on_gp1000408
123b.b26x3 ghrelin_on_gp00406
124b.l27x1 ghrelin_on_gp1000709
125b.l27x2 ghrelin_on_gp66.66670409
126b.b28x2 ghrelin_on_gp66.66670404
127b.b28x4 ghrelin_on_gp66.66670506
128b.b28x6 ghrelin_on_gp1000509
129g.h1x8 ghrelin_on_gp00407
130g.h1x11 ghrelin_on_gp00409
131g.h2x9 ghrelin_on_gp33.33330404
132g.h2x11 ghrelin_on_gp1000406
133g.ctx3 ghrelin_on_gp1000509
134g.ctx6 ghrelin_on_gp00506
135g.ctx14 ghrelin_on_gp33.33330409
136g.ctx15 ghrelin_on_gp66.66670409
137g.ctx16 ghrelin_on_gp1000808
1381x31 ghrelin_on_gp00423
1391x43 ghrelin_on_gp00437
1401x47 ghrelin_on_gp00436
141I1x48 ghrelin_on_gp00416
1422x50 ghrelin_on_gp66.66670439
1432x52 ghrelin_on_gp00437
144E1x52 ghrelin_on_gp00436
1453x43 ghrelin_on_gp33.33330428
1464x38 ghrelin_on_gp00427
1474x50 ghrelin_on_gp66.666750539
1484x61 ghrelin_on_gp66.66670414
149E2.T195 ghrelin_on_gp00433
150E2x51 ghrelin_on_gp00433
1515x39 ghrelin_on_gp33.33330425
1527x34 ghrelin_on_gp33.33330414
1531x60 Shared66.666750455
1542x42 Shared100100578
1552x54 Shared100100566
1562x57 Shared66.66670457
1572x60 Shared66.6667100446
1583x28 Shared66.6667100444
1593x29 Shared66.666750444
1603x30 Shared00446
1613x50 Shared66.666750449
1623x51 Shared100100558
1635x47 Shared66.6667100458
1645x58 Shared10050649
1656x48 Shared100100678
1666x51 Shared66.6667100446
1676x55 Shared66.66670456
1687x38 Shared33.3333100555
1697x41 Shared10050457
1707x42 Shared100100557
1717x53 Shared66.6667100559
1728x50 Shared0100648
173Lig Shared10010020100
1742x63 ghrelin_off33.333350345
1752x65 ghrelin_off00344
1762x66 ghrelin_off00254
177E1x49 ghrelin_off00154
178E1x50 ghrelin_off66.666750347
1793x39 ghrelin_off66.666750349
1803x52 ghrelin_off00345
181E2x52 ghrelin_off050254
1825x54 ghrelin_off33.333350348
1835x66 ghrelin_off00144
1846x44 ghrelin_off100100349
1856x58 ghrelin_off33.33330244
   
Orange: nodes, hubs and links specific of ghrelin_on_gp network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of ghrelin_off network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Owner ghrelin_on_gp Recurrence ghrelin_off Recurrence ghrelin_on_gp Hub1? ghrelin_off Hub1? ghrelin_on_gp Hub2? ghrelin_off Hub2? ConSurf1 ConSurf2
1g.ctx3 g.ctx6 ghrelin_on_gp68.69150YesNoYesNo96
2b.l22x5 g.ctx6 ghrelin_on_gp1000YesNoYesNo96
3b.l22x5 b.lhb1x3 ghrelin_on_gp50.06330YesNoYesNo92
4b.h2x5 b.lhb1x3 ghrelin_on_gp50.02790YesNoYesNo52
5b.h2x1 b.h2x5 ghrelin_on_gp98.96890NoNoYesNo55
6b.b21x5 b.h2x1 ghrelin_on_gp98.89610YesNoNoNo45
7b.b21x5 b.b21x7 ghrelin_on_gp98.67720YesNoYesNo45
8b.b21x7 b.b24x6 ghrelin_on_gp95.31720YesNoNoNo58
9b.b23x6 b.b24x6 ghrelin_on_gp94.68680YesNoNoNo78
10b.b23x6 b.l21x7 ghrelin_on_gp94.1040YesNoNoNo75
11b.l21x7 b.l23x1 ghrelin_on_gp94.18710NoNoNoNo56
12b.l23x1 b.l25x6 ghrelin_on_gp94.02850NoNoYesNo68
13b.l25x6 b.l27x1 ghrelin_on_gp46.11480YesNoYesNo89
14b.b2x1 b.l27x1 ghrelin_on_gp42.910YesNoYesNo89
15b.b2x1 b.b6x1 ghrelin_on_gp40.29340YesNoNoNo89
16b.b6x1 b.l9x6 ghrelin_on_gp40.15490NoNoYesNo98
17G.s3h2.03 b.l9x6 ghrelin_on_gp17.94250YesNoYesNo98
18G.s3h2.03 b.l7x4 ghrelin_on_gp22.50740YesNoNoNo99
19b.l7x4 b.l9x5 ghrelin_on_gp22.35310NoNoNoNo98
20b.l11x2 b.l9x5 ghrelin_on_gp22.19180YesNoNoNo98
21b.l11x2 b.l9x3 ghrelin_on_gp21.37730YesNoYesNo99
22b.l22x5 b.l24x2 ghrelin_on_gp49.77520YesNoYesNo96
23b.h2x5 b.l24x2 ghrelin_on_gp49.80620YesNoYesNo56
24b.b11x4 b.l9x3 ghrelin_on_gp16.1690YesNoYesNo99
25b.b10x3 b.b11x4 ghrelin_on_gp14.6770NoNoYesNo89
26b.b10x3 b.b6x2 ghrelin_on_gp14.50990NoNoNoNo88
27b.b10x2 b.b6x2 ghrelin_on_gp14.34290NoNoNoNo68
285x68 G.H5.16 ghrelin_on_gp11.92990NoNoNoNo56
29G.H5.16 I2x50 ghrelin_on_gp12.25120NoNoNoNo68
30G.H5.12 I2x50 ghrelin_on_gp12.57220NoNoNoNo68
31G.H5.12 I2x51 ghrelin_on_gp12.89320NoNoNoNo67
32G.H5.08 I2x51 ghrelin_on_gp13.2140YesNoNoNo87
33G.H5.08 G.S3.01 ghrelin_on_gp15.13690YesNoNoNo84
34G.S3.01 G.S3.03 ghrelin_on_gp15.44970NoNoYesNo47
35G.S1.04 G.S3.03 ghrelin_on_gp18.96860NoNoYesNo77
36G.S1.04 G.S4.03 ghrelin_on_gp19.28750NoNoNoNo77
37G.H5.07 G.S4.03 ghrelin_on_gp19.60620NoNoNoNo87
38G.H5.07 G.S5.05 ghrelin_on_gp19.92070NoNoYesNo89
39G.S5.05 G.s6h5.01 ghrelin_on_gp20.82930YesNoNoNo99
40G.S5.07 G.s6h5.01 ghrelin_on_gp24.67610YesNoNoNo99
41G.S5.07 G.s5hg.01 ghrelin_on_gp25.94290YesNoYesNo99
42G.HG.03 G.s5hg.01 ghrelin_on_gp31.59340YesNoYesNo69
43G.HG.03 G.HG.07 ghrelin_on_gp37.94990YesNoNoNo69
44G.HG.07 G.s4h3.04 ghrelin_on_gp38.2630NoNoYesNo98
45G.HG.15 G.s4h3.04 ghrelin_on_gp36.72130NoNoYesNo78
46G.HG.15 G.hgh4.05 ghrelin_on_gp37.30640NoNoYesNo77
47G.H4.10 G.hgh4.05 ghrelin_on_gp40.48840YesNoYesNo67
48G.H4.10 G.hgh4.02 ghrelin_on_gp41.35840YesNoYesNo67
49G.H3.06 G.hgh4.02 ghrelin_on_gp45.80590NoNoYesNo67
50G.H3.06 G.H4.15 ghrelin_on_gp24.40830NoNoYesNo68
51G.H3.09 G.H4.15 ghrelin_on_gp22.22010YesNoYesNo98
52G.H3.09 G.S5.02 ghrelin_on_gp41.65370YesNoYesNo96
53G.S4.02 G.S5.02 ghrelin_on_gp46.83660YesNoYesNo86
54G.H3.18 G.S4.02 ghrelin_on_gp46.54280YesNoYesNo98
55G.H3.15 G.H3.18 ghrelin_on_gp47.46460NoNoYesNo89
56G.H3.15 G.H3.17 ghrelin_on_gp47.54710NoNoYesNo85
57G.H3.17 b.l25x6 ghrelin_on_gp47.75270YesNoYesNo58
58G.H3.06 G.h4s6.01 ghrelin_on_gp21.69020NoNoNoNo64
59G.H3.09 G.h4s6.01 ghrelin_on_gp21.94050YesNoNoNo94
60G.H2.06 b.l9x6 ghrelin_on_gp29.92440YesNoYesNo98
61G.H2.04 G.H3.08 ghrelin_on_gp11.26590YesNoNoNo99
62G.H2.06 b.l19x1 ghrelin_on_gp29.17820YesNoYesNo99
63G.H3.08 G.S4.04 ghrelin_on_gp11.15920NoNoNoNo99
64G.H5.22 G.H5.23 ghrelin_on_gp86.77660NoNoYesNo44
652x37 G.H5.22 ghrelin_on_gp88.34940NoNoNoNo74
66I1x49 I1x50 ghrelin_on_gp89.66830NoNoNoNo68
67I1x49 b.l25x4 ghrelin_on_gp89.83380NoNoYesNo65
68b.l25x4 b.l27x2 ghrelin_on_gp91.67680YesNoYesNo59
69b.l25x3 b.l27x2 ghrelin_on_gp92.38090YesNoYesNo99
70b.b27x3 b.l25x3 ghrelin_on_gp61.66860NoNoYesNo89
71b.b27x3 b.b28x6 ghrelin_on_gp31.56060NoNoYesNo89
72b.b28x6 b.lhb1x11 ghrelin_on_gp63.93550YesNoNoNo94
73b.lhb1x11 g.ctx5 ghrelin_on_gp64.18290NoNoNoNo49
74g.ctx3 g.ctx5 ghrelin_on_gp64.24180YesNoNoNo99
75b.b28x4 b.l25x3 ghrelin_on_gp31.51990YesNoYesNo69
76b.b28x4 b.b28x6 ghrelin_on_gp32.29850YesNoYesNo69
773x50 G.H5.23 ghrelin_on_gp85.18680YesYesYesNo94
783x50 7x53 ghrelin_on_gp75.06280YesYesYesYes99
79b.l17x5 b.l19x1 ghrelin_on_gp29.09840NoNoYesNo69
80b.l17x5 b.l19x2 ghrelin_on_gp28.94280NoNoYesNo69
81b.l17x3 b.l19x2 ghrelin_on_gp20.40680YesNoYesNo99
82b.b19x4 b.l17x3 ghrelin_on_gp12.02840YesNoYesNo89
83b.b17x7 b.b20x6 ghrelin_on_gp19.76950YesNoYesNo86
84b.b17x7 b.b21x1 ghrelin_on_gp17.81420YesNoYesNo87
85b.1x19 b.b21x1 ghrelin_on_gp14.38870NoNoYesNo27
86b.1x15 b.1x19 ghrelin_on_gp13.89220NoNoNoNo42
87b.1x12 b.1x15 ghrelin_on_gp12.8990NoNoNoNo14
88b.1x12 g.h1x11 ghrelin_on_gp12.40220NoNoYesNo19
89b.1x10 g.h1x11 ghrelin_on_gp10.91130NoNoYesNo89
90b.b20x4 b.b20x6 ghrelin_on_gp14.49580YesNoYesNo86
91b.b23x1 g.ctx6 ghrelin_on_gp31.28160YesNoYesNo56
92b.b23x1 b.b24x5 ghrelin_on_gp31.0190YesNoNoNo55
93b.b23x3 b.b24x5 ghrelin_on_gp30.85920NoNoNoNo75
94b.b23x3 b.b26x3 ghrelin_on_gp30.48440NoNoYesNo76
95b.b26x3 b.b27x3 ghrelin_on_gp30.31060YesNoNoNo68
966x51 Lig ghrelin_on_gp34.88151.40393YesYesYesYes60
976x48 6x51 ghrelin_on_gp43.0670YesYesYesYes86
983x43 7x53 ghrelin_on_gp62.38740YesNoYesYes89
99G.H2.04 G.H2.07 ghrelin_on_gp10.9720YesNoYesNo99
1002x37 2x40 Shared88.613415.5293NoNoNoNo78
1012x40 I1x50 Shared89.141114.2779NoNoNoNo88
1026x44 6x48 Shared54.8617100NoYesYesYes98
1033x43 6x44 Shared56.507883.0003YesNoNoYes89
1046x48 7x41 Shared10.606314.4617YesYesYesYes87
105NT.F38 NT.Q36 ghrelin_off013.8321NoNoNoNo00
1062x66 NT.Q36 ghrelin_off014.7745NoYesNoNo40
1072x65 2x66 ghrelin_off0.58908718.7478NoYesNoYes44
1081x36 2x65 ghrelin_off0.29456921.6417NoNoNoYes64
1091x36 2x61 ghrelin_off022.4747NoNoNoNo67
1102x61 7x38 ghrelin_off023.1239NoNoYesYes75
1112x54 7x42 ghrelin_off2.7215319.1819YesYesYesYes67
1122x57 7x42 ghrelin_off1.803910.637YesYesYesYes77
1132x54 7x46 ghrelin_off2.5885712.5142YesYesNoNo69
1142x50 7x46 ghrelin_off2.8616912.0684YesNoNoNo99
1157x38 Lig ghrelin_off0.72056620.9808YesYesYesYes50
1166x48 Lig ghrelin_off086.3283YesYesYesYes80
1173x39 6x44 ghrelin_off058.5116NoYesNoYes99
1183x39 7x49 ghrelin_off0.31217230.2648NoYesNoNo99
1197x49 7x53 ghrelin_off028.0044NoNoYesYes99
1207x53 8x50 ghrelin_off013.7812YesYesYesYes98
1217x54 8x50 ghrelin_off3.2046512.2874NoNoYesYes78
1227x54 8x51 ghrelin_off010.9577NoNoNoNo78
1237x41 7x42 ghrelin_off6.3730714.4695YesYesYesYes77
1242x53 7x41 ghrelin_off3.8101111.9158NoNoYesYes77
1252x53 3x35 ghrelin_off3.5091710.4532NoNoNoNo78
1262x46 3x43 ghrelin_off5.7096782.3198NoNoYesNo98
1272x46 3x42 ghrelin_off0.3050981.6315NoNoNoNo98
1282x42 3x42 ghrelin_off080.9354YesYesNoNo88
1292x42 3x46 ghrelin_off5.3123666.986YesYesNoNo88
1302x39 3x46 ghrelin_off058.1088NoNoNoNo88
1312x37 2x39 ghrelin_off016.7729NoNoNoNo78
1321x60 I1x50 ghrelin_off010.4767YesYesNoNo58
1332x42 4x42 ghrelin_off2.0693810.1873YesYesNoNo87
1342x39 3x50 ghrelin_off044.3276NoNoYesYes89
1352x49 3x39 ghrelin_off026.4401NoNoNoYes89
136E1x49 E1x50 ghrelin_off049.6969NoYesNoYes47
1372x59 E1x50 ghrelin_off059.9703NoNoNoYes57
1382x59 3x28 ghrelin_off0.88350361.5619NoNoYesYes54
1392x63 3x28 ghrelin_off034.1754NoYesYesYes54
1403x28 3x29 ghrelin_off0.88381131.8016YesYesYesYes44
1412x49 4x50 ghrelin_off0.58144125.2591NoNoYesNo89
1424x50 4x54 ghrelin_off1.794121.6691YesNoNoNo94
1433x30 4x54 ghrelin_off2.381517.8992YesYesNoNo64
1446x55 Lig ghrelin_off0.015652231.876YesYesYesYes60
1453x33 6x55 ghrelin_off1.1455416.6986NoNoYesYes46
1463x33 3x37 ghrelin_off1.7443213.9338NoNoNoNo46
1473x37 5x46 ghrelin_off2.3085712.4164NoNoNoNo66
1483x46 6x37 ghrelin_off011.7516NoNoNoNo88
1495x58 6x37 ghrelin_off0.29734110.4767YesYesNoNo98
1503x50 6x30 ghrelin_off038.1917YesYesNoNo96
1513x54 6x30 ghrelin_off037.4643NoNoNoNo96
1523x54 5x61 ghrelin_off0.88889129.8189NoNoNoNo98
1533x51 5x61 ghrelin_off027.5116YesYesNoNo88
1543x51 3x52 ghrelin_off0.97449110.0231YesYesNoYes85
1552x67 E1x49 ghrelin_off046.3963NoNoNoYes34
1562x67 E2.E197 ghrelin_off4.7193742.6968NoNoNoNo34
157E2.E197 E2x51 ghrelin_off4.4252626.7725NoNoYesNo43
158E2.E197 E2.T195 ghrelin_off014.7785NoNoYesNo43
159E2x51 E2x52 ghrelin_off3.2498117.0349YesNoNoYes34
1605x40 6x55 ghrelin_off017.5629NoNoYesYes56
1615x40 6x59 ghrelin_off2.3647114.7824NoNoNoNo54
1625x47 6x48 ghrelin_off013.7187YesYesYesYes88
1636x36 7x53 ghrelin_off011.7516NoNoYesYes89
1646x36 7x56 ghrelin_off0.57738710.4767NoNoNoNo87
1656x59 6x60 ghrelin_off013.2768NoNoNoNo44
1662x63 Lig ghrelin_off2.3415230.6949NoYesYesYes50
1673x29 Lig ghrelin_off1.4561238.0626YesYesYesYes40
1682x50 3x39 ghrelin_off0.053679414.0941YesNoNoYes99

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Midway



Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Node1Node2OwnerNet1LinkStrengthNet2LinkStrengthComm1Comm2Node1ShellNode2Shell
2x537x41Shared6.285.443330021
2x602x63ghrelin_off8.3401411
2x607x38Shared12.547.961411
2x607x42Shared7.4753.451412
2x60LigShared20.9754.686671410
2x617x38ghrelin_off4.2600021
2x633x28ghrelin_off4.27501412
2x633x29ghrelin_off5.25501411
2x63LigShared16.3755.883331410
2x647x38Shared13.3954.870411
3x283x29Shared5.8559.366671021
3x294x65Shared4.39.073331412
3x29LigShared10.8517.33331410
3x32LigShared6.5251.783330010
3x333x37Shared7.8610.10330412
3x334x61ghrelin_off6.83500411
3x336x55Shared5.81510.470411
3x366x48ghrelin_off7.8800021
3x396x44ghrelin_off6.825002022
3x406x44ghrelin_off5.24500022
4x605x39Shared8.3855.033330021
5x395x42Shared4.5652.030412
5x476x48ghrelin_off5.01501021
5x476x52Shared22.0613.95331022
6x446x48Shared7.51515.36670021
6x477x45Shared4.35.740022
6x486x52ghrelin_off11.10501012
6x487x41Shared7.5154.676671011
6x487x45ghrelin_off4.9401012
6x516x52Shared10.185.661412
6x516x55Shared9.08511.761411
6x517x41ghrelin_off6.4301411
6x51LigShared5.054.673331410
6x55LigShared16.6821.23671410
6x586x62Shared4.2857.503336412
7x317x32ghrelin_off7.32500412
7x387x42Shared9.28512.72331412
7x38LigShared4.63510.821410
7x417x42Shared8.7658.943331012
7x41Ligghrelin_off18.1901010
7x31NT.L37ghrelin_off5.32500412
7x31NT.F38ghrelin_off3.51500412
2x67E1x49ghrelin_off13.2100412
E1x49E1x50ghrelin_off12.1600022
5x406x55ghrelin_off5.88500021
6x48Ligghrelin_off9.7301010
6x587x30ghrelin_off3.96506412
5x436x55Shared3.2954.833330021
4x64E2.A204ghrelin_off3.15500412
4x644x65ghrelin_off2.9800412
2x67E2.E197Shared2.8054.490412
6x587x29ghrelin_off2.5106412
7x37Ligghrelin_off2.26500010
7x307x34Shared2.2353.973330021
6x58E2x52ghrelin_off2.16506412
6x62E2x52ghrelin_off2.16506022
E1.R107E1x49ghrelin_off2.1600012
4x645x35Shared2.0752.766670412
2x622x67ghrelin_off1.89500021
6x617x26ghrelin_off0.77500412
2x603x28ghrelin_on_gp06.371412
2x632x67ghrelin_on_gp03.773331411
2x63E1x50ghrelin_on_gp071412
2x64Ligghrelin_on_gp08.726670410
2x67Ligghrelin_on_gp05.243330410
E1.R107Ligghrelin_on_gp05.613330010
3x294x61ghrelin_on_gp03.661411
3x304x61ghrelin_on_gp03.354021
3x33Ligghrelin_on_gp014.38670410
3x367x41ghrelin_on_gp06.920021
3x375x43ghrelin_on_gp05.936670022
3x396x48ghrelin_on_gp04.2533302021
3x406x48ghrelin_on_gp04.903330021
4x614x65ghrelin_on_gp04.096670412
4x61Ligghrelin_on_gp04.390410
4x645x39ghrelin_on_gp04.710411
4x64Ligghrelin_on_gp05.203330410
5x35E2.A204ghrelin_on_gp03.680022
5x39Ligghrelin_on_gp06.806670410
6x486x51ghrelin_on_gp07.683331011
6x547x34ghrelin_on_gp04.523330021
6x58Ligghrelin_on_gp014.75336410
6x616x62ghrelin_on_gp03.520412
6x61Ligghrelin_on_gp03.896670410
7x31Ligghrelin_on_gp07.386670410
7x34Ligghrelin_on_gp018.90330410
5x436x52ghrelin_on_gp04.183330022
1x322x64ghrelin_on_gp03.230021
7x347x37ghrelin_on_gp02.980411
1x397x38ghrelin_on_gp02.790021
6x476x48ghrelin_on_gp02.176670021
1x287x31ghrelin_on_gp01.580021

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
Id Description
ghrelin_on_gp 7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
ghrelin_off 6KO5-Ghrelin-PubChem 57400002
7F83-Ghrelin-PF-05190457
Network Difference
Value ghrelin_on_gp ghrelin_off
Imin 3.24 3.515
Number of Linked Nodes 899 295
Number of Specific Nodes 619 (68.85%) 15  (5.08%)
Number of Shared Nodes 280 (31.15%) 280  (94.92%)
Number of Links 1078 315
Number of Specific Links 911 (84.51%) 148  (46.98%)
Number of Shared Links 167 (15.49%) 167  (53.02%)
Number of Hubs 173 33
Number of Specific Hubs 152 (87.86%) 12  (36.36%)
Number of Shared Hubs 21 (12.14%) 21  (63.64%)
Average % Shared Neighbours (Jaccard) 12.68
Average % Shared Neighbours (Otsuka) 15.78
Average % Shared Neighbours (Overlap Coefficient) 18.77
Average % Shared Cliques (k3-6) 50.76
Graphlets Similarity 0.654114
Paths Difference
Value ghrelin_on_gp ghrelin_off
Number Of Nodes in MetaPath 103 68
Specific Nodes in MetaPath 93 (90.29%) 58  (85.29%)
Shared Nodes in MetaPath 280 (31.15%) 280  (31.15%)
Number Of Links MetaPath 104 69
Specific Links in MetaPath 99 (95.19%) 64  (92.75%)
Shared Links in MetaPath 167 (15.49%) 167  (15.49%)
Number of Shortest Paths 2487568 54220
Length Of Smallest Path 3 3
Average Path Length 42.7885 14.099
Length of Longest Path 84 33
Minimum Path Strength 0.841667 0.7
Average Path Strength 6.49765 6.464
Maximum Path Strength 21.4667 19.5825
Minimum Path Correlation 0.7 0.7
Average Path Correlation 0.981046 0.92025
Maximum Path Correlation 1 0.99
Minimum % Of Corr. Nodes 1.47059 3.33333
Average % Of Corr. Nodes 31.2589 45.8883
Maximum % Of Corr. Nodes 100 100
Minimum Path Hubs % 0 0
Average Path Hubs % 56.731 40.7687
Maximum Path Hubs % 100 100

Details about the values in these tables can be found in the corresponding documentation page .

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download ghrelin_off_on_gp.zip<



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