Orange: nodes, hubs and links specific of gip_on_allo network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of gip_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.


Index Hub Owner gip_on_allo Avg Int. Strength gip_on Avg Int. Strength gip_on_allo Num Of Links gip_on Num Of Links ConSurf
1NT.W39 gip_on_allo9.359.36583436
2NT.Y42 gip_on_allo7.7855.99167437
3NT.R43 gip_on_allo5.6854.34417434
4NT.Y68 gip_on_allo12.655.3475515
5NT.Y87 gip_on_allo8.1427.10583534
6NT.P89 gip_on_allo9.55254.50625423
7NT.W109 gip_on_allo9.635712.955739
8NT.R113 gip_on_allo8.56756.38426
9NT.P121 gip_on_allo8.4543.0175522
101x54 gip_on_allo5.5353.9375439
112x46 gip_on_allo8.95.79833439
122x54 gip_on_allo5.993.35125429
132x71 gip_on_allo3.8055.53375427
143x34 gip_on_allo4.06256.05125425
153x44 gip_on_allo6.0947.28167538
16E2x52 gip_on_allo9.27258.70417436
17E2.V292 gip_on_allo4.844.5425436
185x37 gip_on_allo8.9113.27436
195x62 gip_on_allo4.741.845435
206x34 gip_on_allo4.8755.46875425
216x42 gip_on_allo3.293.1325429
22Alloh67 gip_on_allo12.41570700
23Lig Shared15.051311.562839390
24NT.W71 Shared7.20754.70833869
25NT.W90 Shared11.45756.489454
261x43 Shared9.36255.7875447
271x47 Shared6.00755.29143477
282x57 Shared8.0947.084558
292x60 Shared7.8486.83375548
302x67 Shared12.1927.49625546
313x46 Shared13.03839.0025659
323x50 Shared8.418.05449
333x53 Shared7.7886.09875548
344x53 Shared4.75255.13449
354x60 Shared9.8186.968558
364x64 Shared10.4959.52458
37E2x51 Shared14.1358.05958469
387x34 Shared6.2853.21125445
398x56 Shared6.68753.6985458
40NT.T31 gip_on8.533333.61812345
41NT.Y73 gip_on01.2845054
42NT.P85 gip_on5.265.14063348
43NT.W86 gip_on11.3254.23875241
44NT.L100 gip_on2.952.43144
451x58 gip_on7.122.89125246
463x37 gip_on11.875.73687346
473x48 gip_on3.903335.53125348
484x46 gip_on5.584.094358
494x68 gip_on5.725.63345
505x40 gip_on9.666677.17188347
515x54 gip_on7.77.015359
525x57 gip_on5.043.49938249
535x65 gip_on5.112.235247
546x52 gip_on13.67676.80625348
556x53 gip_on4.2956.63812247
566x56 gip_on12.175.4855257
577x37 gip_on5.2054.63063247
587x41 gip_on9.4857.25438247
597x51 gip_on9.243335.6345
607x57 gip_on10.348.09562248
   
Orange: nodes, hubs and links specific of gip_on_allo network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of gip_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Owner gip_on_allo Recurrence gip_on Recurrence gip_on_allo Hub1? gip_on Hub1? gip_on_allo Hub2? gip_on Hub2? ConSurf1 ConSurf2
1Lig NT.L35 gip_on_allo17.8650.637264YesYesNoNo05
2NT.L35 NT.P89 gip_on_allo16.57270NoNoYesNo53
3NT.R43 NT.W39 gip_on_allo19.50670YesNoYesNo46
4Lig NT.Y87 gip_on_allo27.63090YesYesYesNo04
5NT.P85 NT.Y87 gip_on_allo27.33631.48828NoYesYesNo84
6NT.R113 NT.W71 gip_on_allo30.5270YesNoYesYes69
7NT.W109 NT.W71 gip_on_allo28.26230YesNoYesYes99
8NT.G63 NT.W109 gip_on_allo22.24280NoNoYesNo49
9NT.D72 NT.G63 gip_on_allo15.92860NoNoNoNo64
10NT.R101 NT.R113 gip_on_allo26.36390NoNoYesNo86
11NT.R101 NT.W109 gip_on_allo24.97476.94751NoNoYesNo89
12NT.D72 NT.P56 gip_on_allo12.75890NoNoNoNo61
13NT.C84 NT.P85 gip_on_allo25.80820NoNoNoYes98
14NT.C84 NT.G97 gip_on_allo22.22189.20581NoNoNoNo96
15NT.F98 NT.G97 gip_on_allo18.60160NoNoNoNo36
16NT.F98 NT.R81 gip_on_allo16.77896.12836NoNoNoNo34
17NT.R81 NT.T79 gip_on_allo14.94780NoNoNoNo45
18NT.P89 NT.W90 gip_on_allo12.1191.42721YesNoYesYes34
19NT.Q102 NT.T79 gip_on_allo13.10830NoNoNoNo45
20NT.Q108 NT.W109 gip_on_allo15.92860NoNoYesNo59
21NT.D106 NT.Q108 gip_on_allo12.75890.657179NoNoNoNo55
227x34 Lig gip_on_allo19.30884.35464YesYesYesYes50
231x47 Lig gip_on_allo14.71212.54375YesYesYesYes70
241x53 7x54 gip_on_allo10.72153.87403NoNoNoNo78
251x54 7x54 gip_on_allo11.47926.99397YesNoNoNo98
261x54 2x54 gip_on_allo21.85134.87109YesNoYesNo99
271x58 2x54 gip_on_allo19.95710NoYesYesNo69
281x58 2x51 gip_on_allo18.73213.32838NoYesNoNo67
292x46 3x53 gip_on_allo12.69150YesNoYesYes98
301x63 1x64 gip_on_allo10.86880.776666NoNoNoNo37
311x62 1x63 gip_on_allo12.38840NoNoNoNo33
321x62 2x51 gip_on_allo13.89960NoNoNoNo37
332x56 3x46 gip_on_allo28.14870.832426NoNoYesYes99
342x56 3x43 gip_on_allo29.54620NoNoNoNo99
352x63 3x36 gip_on_allo12.25373.94838NoNoNoNo66
362x67 Lig gip_on_allo11.68138.08794YesYesYesYes60
37E2x52 Lig gip_on_allo23.4933.68684YesNoYesYes60
382x71 3x29 gip_on_allo15.25510YesNoNoNo79
39E1.P195 E2x52 gip_on_allo10.63730NoNoYesNo36
40E2x50 E2x52 gip_on_allo10.63731.52014NoNoYesNo96
41E1.P197 Lig gip_on_allo10.49420.625315NoNoYesYes40
423x37 5x37 gip_on_allo52.94240NoYesYesNo66
435x37 Lig gip_on_allo56.03224.348YesNoYesYes60
443x34 4x60 gip_on_allo11.71070YesNoYesYes58
453x37 5x39 gip_on_allo12.57370.740819NoYesNoNo67
463x45 4x491 gip_on_allo10.72156.49611NoNoNoNo69
473x46 4x491 gip_on_allo19.58667.298YesYesNoNo99
484x56 5x39 gip_on_allo12.15270NoNoNoNo57
495x54 6x51 gip_on_allo27.82887.26083NoYesNoNo96
506x46 6x51 gip_on_allo37.40530.0185869NoNoNoNo86
516x46 Alloh67 gip_on_allo38.29770NoNoYesNo80
526x55 Alloh67 gip_on_allo55.32080NoNoYesNo60
536x55 6x56 gip_on_allo56.53311.27187NoNoNoYes67
546x56 7x41 gip_on_allo57.7375.52694NoYesNoYes77
557x41 Lig gip_on_allo58.75999.70765NoYesYesYes70
563x53 3x57 gip_on_allo13.71021.66352YesYesNoNo88
575x36 E2.V292 gip_on_allo10.60361.552NoNoYesNo36
584x68 E2.V292 gip_on_allo15.02361.53873NoYesYesNo56
594x64 4x68 gip_on_allo16.43373.04161YesYesNoYes85
605x54 6x42 gip_on_allo20.86210NoYesYesNo99
617x52 Alloh67 gip_on_allo10.10690NoNoYesNo60
625x62 6x38 gip_on_allo12.22015.82964YesNoNoNo59
635x58 6x38 gip_on_allo13.71020NoNoNoNo79
647x33 7x34 gip_on_allo10.66260NoNoYesYes45
65Lig NT.W39 Shared19.384613.8286YesYesYesNo06
66Lig NT.R113 Shared54.512517.0269YesYesYesNo06
671x54 2x57 Shared34.803812.0589YesNoYesYes98
682x57 3x43 Shared81.613151.6582YesYesNoNo89
692x60 3x43 Shared10096.3517YesYesNoNo89
702x60 Lig Shared96.139989.7865YesYesYesYes80
712x49 3x53 Shared33.031736.3148NoNoYesYes98
722x49 3x50 Shared39.787839.833NoNoYesYes99
732x53 3x50 Shared45.799100NoNoYesYes99
742x53 2x57 Shared48.31255.5468NoNoYesYes98
754x60 4x64 Shared26.149211.9368YesYesYesYes88
763x37 4x60 Shared39.12717.8102NoYesYesYes68
775x58 6x42 Shared15.19231.5432NoNoYesNo79
78Lig NT.W90 gip_on016.7893YesYesYesYes04
79NT.D66 NT.W71 gip_on1.9195215.8533NoNoYesYes99
80NT.D66 NT.R113 gip_on016.4388NoNoYesNo96
81NT.V94 NT.W90 gip_on011.0685NoNoYesYes34
82NT.C84 NT.V94 gip_on010.4551NoNoNoNo93
831x64 I1x50 gip_on013.5963NoNoNoNo79
848x50 I1x50 gip_on015.054NoNoNoNo99
858x47 8x50 gip_on1.5785515.7789NoNoNoNo99
862x46 8x47 gip_on016.3325YesNoNoNo99
872x46 2x50 gip_on018.4833YesNoNoNo99
882x50 3x50 gip_on3.1528946.284NoNoYesYes99
892x53 3x47 gip_on1.5406644.9351NoNoNoNo99
903x43 3x47 gip_on044.9935NoNoNoNo99
911x64 8x53 gip_on9.340812.1279NoNoNoNo78
922x50 7x57 gip_on1.5785530.1253NoNoNoYes98
936x48 7x57 gip_on1.4985728.5215NoNoNoYes98
943x50 6x48 gip_on3.0729129.1562YesYesNoNo99
953x46 3x49 gip_on1.5532918.5032YesYesNoNo98
963x49 4x46 gip_on020.0459NoNoNoYes88
973x53 4x46 gip_on0.60195331.2777YesYesNoYes88
983x37 Lig gip_on019.4976NoYesYesYes60
995x57 6x45 gip_on013.0586NoYesNoNo99
1005x54 6x45 gip_on6.1921214.4699NoYesNoNo99
1015x54 5x58 gip_on030.1373NoYesNoNo97
1026x38 6x42 gip_on032.9466NoNoYesNo99
1035x65 6x38 gip_on039.9233NoYesNoNo79
1045x65 6x37 gip_on1.7721848.5423NoYesNoNo79
1056x37 6x40 gip_on3.0981652.3021NoNoNoNo99
1066x40 6x44 gip_on5.9016753.6629NoNoNoNo98
1076x44 7x57 gip_on056.0394NoNoNoYes88

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Midway



Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Node1Node2OwnerNet1LinkStrengthNet2LinkStrengthComm1Comm2Node1ShellNode2Shell
NT.E34NT.T31Shared612.70021
E2.R289NT.T31gip_on4.527501011
LigNT.L35Shared10.307515.791101
LigNT.Y36Shared7.8056.191101
NT.F65NT.W39gip_on3.7600021
NT.W39NT.Y87Shared7.71511.581111
LigNT.W39Shared16.622511.841101
NT.P85NT.Y42Shared5.2155.561122
NT.Y42NT.Y87Shared7.6956.951121
NT.F65NT.R43Shared7.2156.410022
NT.D66NT.W71Shared5.8657.820122
NT.D66NT.R113gip_on5.362500121
LigNT.M67Shared6.78756.41101
LigNT.Y68Shared5.347520.181101
NT.V69NT.W71Shared4.59758.580122
NT.P85NT.V69gip_on5.742501122
NT.R101NT.W71Shared8.497560122
NT.P85NT.Y87Shared5.90758.341121
NT.L88NT.P85gip_on3.697500122
NT.L88NT.W90Shared3.75.690121
NT.P89NT.W90Shared7.432520.270121
NT.V94NT.W90gip_on3.98500021
NT.N120NT.W90Shared13.277515.820121
LigNT.W90gip_on4.0501101
LigNT.R113Shared7.39756.261101
LigNT.H115Shared8.447.951101
NT.N120NT.P121Shared4.896.520122
1x261x29gip_on3.622501011
1x26Liggip_on4.701010
1x291x32gip_on4.97501112
1x29LigShared6.343.571110
1x33LigShared10.88256.190110
1x36LigShared11.95512.040010
1x37LigShared6.23256.731110
1x39LigShared3.353.651110
1x401x43Shared5.35510.151111
1x402x68gip_on6.201111
1x40LigShared12.91755.811110
1x431x47Shared5.21255.961111
1x437x42gip_on3.6301111
1x43LigShared8.952514.441110
1x472x60gip_on4.11501111
1x472x64gip_on8.4601111
1x477x46Shared9.21755.091112
1x47LigShared5.0658.981110
2x603x40Shared5.8859.151111
2x603x43Shared10.242513.261112
2x60LigShared7.09256.711110
2x673x33Shared7.0123.361112
2x673x36Shared7.4411.641112
2x67LigShared13.80510.351110
2x71E1.P195gip_on4.107500022
2x71E2x52gip_on6.9600021
E1.R196Liggip_on3.15500010
3x333x37gip_on4.800021
3x374x60Shared6.2975231112
3x375x39Shared4.80258.231112
3x37Liggip_on7.047501110
3x40LigShared12.292516.41110
3x445x43Shared9.6712.091112
3x445x47gip_on5.442501112
3x446x53Shared6.73254.491112
4x605x39Shared13.21255.871122
E2x50E2x52Shared4.566.080021
E2x52LigShared14.592511.391110
E2.R289LigShared13.820.121010
5x37E2.N290Shared21.479.041111
E2.N290LigShared7.82255.961110
5x375x40Shared10.7515.991112
5x37LigShared7.596.231110
5x40E3.E362gip_on3.7800022
5x476x53Shared5.814.11022
6x537x41gip_on5.392501021
6x567x37gip_on6.822501022
6x567x41Shared11.952515.161021
7x34E3.E362gip_on3.197501112
7x34LigShared7.25.961110
7x377x41gip_on6.412501021
7x38LigShared5.77256.360110
7x41LigShared5.263.811110
7x42LigShared8.457513.451110
7x45LigShared3.95511.50110
2x64LigShared3.387510.621110
E1.P197LigShared5.56251.640110
E1.Y200LigShared3.85756.051010
LigNT.A32Shared2.727.911101
1x30LigShared2.68258.490010
1x472x65gip_on2.637501112
1x397x39Shared2.5651.711112
E1.G198E1.P199Shared2.53754.060021
1x351x39gip_on2.49500021
E1.P199Liggip_on2.482501010
1x472x61Shared2.332541112
6x567x33gip_on2.132501022
E2.Q285NT.T31Shared2.1255.670021
7x34E3.A365gip_on2.072501112
NT.G33NT.T31gip_on1.8200021
2x673x32gip_on1.7301112
E1.D203E1.L201gip_on1.357500021
3x25E1.W209gip_on1.29500022
1x371x41gip_on1.072501112
2x682x69gip_on0.892500112
E1.L201E1.Y200gip_on0.8800111
E1.G202NT.Y36gip_on0.72500021
7x317x34gip_on0.37500021
1x341x37gip_on0.332500021
3x44Liggip_on_allo03.971110
2x68Liggip_on_allo07.230110
LigNT.T31gip_on_allo07.231101
LigNT.Y87gip_on_allo06.891101
E1.L201Liggip_on_allo011.870110
NT.L35NT.P89gip_on_allo09.850112
E1.L201NT.Y36gip_on_allo08.210111
NT.R43NT.W39gip_on_allo070021
NT.M67NT.W39gip_on_allo06.980111
NT.D66NT.Y68gip_on_allo014.940121
NT.D66NT.V69gip_on_allo07.30122
NT.V69NT.Y68gip_on_allo08.830121
NT.Y68NT.Y87gip_on_allo06.950111
NT.R113NT.Y68gip_on_allo012.351111
NT.R113NT.W71gip_on_allo051112
NT.L88NT.P89gip_on_allo04.930122
NT.P121NT.W90gip_on_allo04.050121
NT.P121NT.V94gip_on_allo05.30122
NT.R101NT.R113gip_on_allo010.660121
NT.E119NT.H115gip_on_allo011.080021
1x261x28gip_on_allo04.691012
1x271x29gip_on_allo08.160021
1x327x34gip_on_allo09.350021
1x331x37gip_on_allo08.140111
1x427x42gip_on_allo04.370021
1x432x68gip_on_allo06.91111
2x603x44gip_on_allo06.171111
2x607x45gip_on_allo03.951111
2x643x36gip_on_allo06.081112
2x672x68gip_on_allo014.291111
2x713x32gip_on_allo04.730022
E1.P195E2x52gip_on_allo09.430021
E1.R196E1.W209gip_on_allo050012
3x25E1.R196gip_on_allo05.530021
E1.P199E1.W209gip_on_allo04.051012
3x33E2x52gip_on_allo010.190021
3x375x37gip_on_allo04.381111
5x405x43gip_on_allo05.010022
7x337x34gip_on_allo06.070021
1x357x34gip_on_allo03.760021
3x445x46gip_on_allo03.751112
1x331x34gip_on_allo03.640112
NT.G33NT.Y36gip_on_allo02.90021
7x337x37gip_on_allo02.820022
7x387x39gip_on_allo01.710112
E1.P197E1.R196gip_on_allo01.440111
2x662x67gip_on_allo01.320021

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
Id Description
gip_on_allo 7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
gip_on 7DTY-GIP-GIP-Gs/&β;1/&γ;2
7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
Network Difference
Value gip_on_allo gip_on
Imin 3.81 3.12
Number of Linked Nodes 344 357
Number of Specific Nodes 19 (5.52%) 32  (8.96%)
Number of Shared Nodes 325 (94.48%) 325  (91.04%)
Number of Links 387 385
Number of Specific Links 166 (42.89%) 164  (42.60%)
Number of Shared Links 221 (57.11%) 221  (57.40%)
Number of Hubs 39 38
Number of Specific Hubs 22 (56.41%) 21  (55.26%)
Number of Shared Hubs 17 (43.59%) 17  (44.74%)
Average % Shared Neighbours (Jaccard) 40.22
Average % Shared Neighbours (Otsuka) 49.58
Average % Shared Neighbours (Overlap Coefficient) 58.90
Average % Shared Cliques (k3-6) 78.85
Graphlets Similarity 0.580705
Paths Difference
Value gip_on_allo gip_on
Number Of Nodes in MetaPath 79 42
Specific Nodes in MetaPath 55 (69.62%) 18  (42.86%)
Shared Nodes in MetaPath 325 (94.48%) 325  (94.48%)
Number Of Links MetaPath 77 43
Specific Links in MetaPath 64 (83.12%) 30  (69.77%)
Shared Links in MetaPath 221 (57.11%) 221  (57.11%)
Number of Shortest Paths 68158 112234
Length Of Smallest Path 3 3
Average Path Length 11.2719 15.2501
Length of Longest Path 28 34
Minimum Path Strength 1.09 0.35625
Average Path Strength 7.68402 6.06116
Maximum Path Strength 21.99 16.11
Minimum Path Correlation 0.7 0.7
Average Path Correlation 0.955719 0.934695
Maximum Path Correlation 1 0.99
Minimum % Of Corr. Nodes 5.55556 3.57143
Average % Of Corr. Nodes 62.3743 41.0895
Maximum % Of Corr. Nodes 100 100
Minimum Path Hubs % 0 0
Average Path Hubs % 40.4579 37.5776
Maximum Path Hubs % 100 100

Details about the values in these tables can be found in the corresponding documentation page .

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