Orange: nodes, hubs and links specific of glp1_on_allo network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of glp1_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.


   
Orange: nodes, hubs and links specific of glp1_on_allo network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of glp1_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Midway



Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Node1Node2OwnerNet1LinkStrengthNet2LinkStrengthComm1Comm2Node1ShellNode2Shell
NT.E34NT.S31Shared6.342.870021
LigNT.S31glp1_on3.8535301101
LigNT.L32Shared5.644129.581101
NT.P90NT.T35glp1_on4.7305901011
LigNT.V36Shared4.006473.931101
NT.R43NT.W39Shared9.2329490021
NT.W39NT.Y88Shared13.787115.431111
LigNT.W39Shared13.316510.111101
NT.Y42NT.Y88Shared9.928245.961121
NT.F66NT.R43glp1_on4.0870600122
NT.E68NT.F66Shared3.909415.831112
NT.D67NT.R121Shared4.203538.340021
LigNT.E68Shared6.8211812.111101
NT.P86NT.Y69Shared5.45.561121
NT.L89NT.Y69glp1_on4.2058801111
NT.L123NT.Y69Shared4.689414.690111
LigNT.Y69glp1_on6.9611801101
NT.P86NT.Y88Shared7.607655.561121
NT.L89NT.P86glp1_on3.6701112
LigNT.Y88glp1_on5.0205901101
NT.L89NT.W91Shared7.6376523.921111
NT.P90NT.W91Shared5.801768.111011
LigNT.P90glp1_on4.3535301101
NT.E128NT.W91glp1_on10.262400011
LigNT.W91glp1_on7.2564701101
NT.L123NT.R121Shared6.215889.720111
1x33LigShared6.1952910.11010
1x357x35Shared9.2358812.880022
1x36LigShared8.2147113.040110
1x397x35glp1_on3.4547101112
1x397x39glp1_on4.2264701112
1x401x43Shared5.138828.941111
1x401x44Shared6.5364713.731112
1x402x68Shared10.208214.941112
1x40Ligglp1_on4.2901110
1x431x47Shared4.496473.971111
1x432x64Shared3.859415.051112
1x432x68Shared5.073538.051112
1x437x42Shared5.310599.381111
1x43LigShared8.911187.221110
1x472x60Shared7.564717.21111
1x472x61Shared3.5329441112
1x472x64Shared9.424127.571112
1x477x46Shared8.303537.631112
1x47LigShared4.038826.731110
2x603x40Shared11.075911.771111
2x603x43Shared10.138813.261112
2x603x44Shared8.1717613.381111
2x607x45Shared4.489415.171112
2x60LigShared4.4470611.631110
2x633x36glp1_on3.7900021
2x672x68Shared6.587659.681112
2x673x33Shared3.428244.961112
2x673x36Shared7.792947.21111
2x67LigShared8.7488215.991110
2x71Ligglp1_on4.6405900010
2x742x75Shared5.774718.380021
2x75LigShared14.934721.311110
E1.Q211E1.W214glp1_on4.3811800021
E1.W214LigShared20.966536.781110
3x33E2x52Shared7.2464712.970021
3x374x60Shared9.277658.761112
3x375x39Shared5.408244.121112
3x37LigShared5.7058810.291110
3x40LigShared8.6623513.841110
3x445x43Shared10.52419.671112
3x445x47glp1_on3.9835301112
3x446x53Shared10.4310.11112
4x605x39Shared12.15765.871122
E2x52LigShared6.5435314.31110
E2.R299LigShared14.710619.541010
5x37E2.N300Shared15.687112.431111
E2.N300LigShared4.295888.941110
5x375x39Shared3.937067.051112
5x375x40Shared14.406591112
5x37LigShared8.6923517.231110
5x40E3.E373Shared5.883539.30022
5x476x53Shared4.260596.831022
6x537x41Shared3.731778.881121
6x537x45Shared3.733537.061122
6x567x37Shared3.430592.481022
6x567x41Shared6.037658.161021
7x34E3.D372Shared3.7841210.721111
E3.D372LigShared4.6158813.011110
7x34LigShared8.3882416.981110
7x377x41glp1_on6.8294101021
7x38LigShared7.528827.960110
7x41Ligglp1_on5.0317601010
7x42LigShared7.7417614.41110
NT.P86NT.Y42Shared6.871186.951122
NT.Y69NT.Y88Shared5.255884.961111
NT.L89NT.Y88glp1_on4.2058801111
2x72Ligglp1_on3.4394100010
NT.E127NT.W91glp1_on3.3347100021
1x39LigShared3.080597.311110
E1.Q210E1.W214glp1_on2.7064700021
E1.Q211E1.Q213Shared2.5610.240022
NT.A70NT.Y69glp1_on2.5094100021
NT.A92NT.L89glp1_on2.3194100021
E2.G295E2.R299glp1_on2.2941200021
LigNT.V30glp1_on2.1029401101
E1.H212E1.Q213glp1_on2.0364700112
1x472x65glp1_on1.9388201112
1x371x41glp1_on1.8458800022
1x331x34glp1_on1.7917601012
1x33NT.S136glp1_on1.5223501012
7x34E3.R376glp1_on1.5047101112
1x401x41Shared1.494712.421112
2x76E1.A209glp1_on1.3076501011
7x34E3.A375Shared1.139412.771112
NT.P137NT.S136Shared1.047061.780112
2x76Ligglp1_on0.9301010
NT.P137NT.T29glp1_on0.82294100112
7x31E3.R376glp1_on0.61764701022
7x317x34glp1_on0.61764701021
NT.E128NT.S129glp1_on0.33823500012
E1.L218NT.V36glp1_on_allo04.470021
NT.E68NT.W39glp1_on_allo04.361111
NT.R121NT.Y69glp1_on_allo05.140111
LigNT.L89glp1_on_allo08.561101
NT.S94NT.W91glp1_on_allo04.940021
LigNT.R121glp1_on_allo05.231101
LigNT.L123glp1_on_allo04.471101
LigNT.E128glp1_on_allo010.81101
1x36NT.P137glp1_on_allo04.930111
LigNT.P137glp1_on_allo011.131101
1x37Alloh12glp1_on_allo021.420021
1x397x38glp1_on_allo04.151111
1x40Alloh12glp1_on_allo032.831111
1x432x67glp1_on_allo04.781111
2x72Alloh12glp1_on_allo018.710011
2x76Alloh12glp1_on_allo08.851011
E1.A209Ligglp1_on_allo04.530010
E1.Q210E1.Q211glp1_on_allo07.680022
E1.H212E1.W214glp1_on_allo09.520111
E1.H212Ligglp1_on_allo08.640110
3x36Ligglp1_on_allo09.030110
3x375x37glp1_on_allo07.671111
3x403x44glp1_on_allo03.791111
3x44Ligglp1_on_allo06.561110
E3.D372E3.E373glp1_on_allo05.21112
Alloh12Ligglp1_on_allo017.730110
2x713x33glp1_on_allo03.650012
NT.P90NT.V30glp1_on_allo03.531011
1x35NT.P137glp1_on_allo03.160021
LigNT.T35glp1_on_allo02.591101
1x442x65glp1_on_allo02.590022
E3.E373E3.R376glp1_on_allo02.330022
7x357x39glp1_on_allo02.140022

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
Id Description
glp1_on 6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
glp1_on_allo 6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
Network Difference
Value glp1_on_allo glp1_on
Imin 3.79 3.35471
Number of Linked Nodes 356 392
Number of Specific Nodes 1 (0.28%) 37  (9.44%)
Number of Shared Nodes 355 (99.72%) 355  (90.56%)
Number of Links 406 433
Number of Specific Links 133 (32.76%) 160  (36.95%)
Number of Shared Links 273 (67.24%) 273  (63.05%)
Number of Hubs 48 54
Number of Specific Hubs 20 (41.67%) 26  (48.15%)
Number of Shared Hubs 28 (58.33%) 28  (51.85%)
Average % Shared Neighbours (Jaccard) 48.86
Average % Shared Neighbours (Otsuka) 58.18
Average % Shared Neighbours (Overlap Coefficient) 68.03
Average % Shared Cliques (k3-6) 56.25
Graphlets Similarity 0.703144
Paths Difference
Value glp1_on_allo glp1_on
Number Of Nodes in MetaPath 64 68
Specific Nodes in MetaPath 28 (43.75%) 32  (47.06%)
Shared Nodes in MetaPath 355 (99.72%) 355  (99.72%)
Number Of Links MetaPath 64 67
Specific Links in MetaPath 39 (60.94%) 42  (62.69%)
Shared Links in MetaPath 273 (67.24%) 273  (67.24%)
Number of Shortest Paths 78328 91639
Length Of Smallest Path 3 3
Average Path Length 11.8772 14.1911
Length of Longest Path 32 40
Minimum Path Strength 1.29 0.466078
Average Path Strength 8.52555 6.29122
Maximum Path Strength 32.99 16.0188
Minimum Path Correlation 0.7 0.700588
Average Path Correlation 0.952839 0.948589
Maximum Path Correlation 1 0.996471
Minimum % Of Corr. Nodes 5 2.7027
Average % Of Corr. Nodes 60.0305 50.3233
Maximum % Of Corr. Nodes 100 100
Minimum Path Hubs % 0 0
Average Path Hubs % 44.0712 44.0534
Maximum Path Hubs % 100 100

Details about the values in these tables can be found in the corresponding documentation page .

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download glp1_on_ortoallo.zip<



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