psnGPCR

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Orange: nodes, hubs and links specific of hca2_on_allo network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of hca2_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	hca2_on_allo Int. Strength	hca2_on Int. Strength	hca2_on_allo Hub1?	hca2_on Hub1?	hca2_on_allo Hub2?	hca2_on Hub2?	ConSurf1	ConSurf2
1	7x25	NT.D8	hca2_on_allo	100	0	Yes	No	No	No	2	6
2	7x25	NT.H9	hca2_on_allo	100	0	Yes	No	No	No	2	6
3	7x28	NT.H9	hca2_on_allo	100	0	No	No	No	No	1	6
4	NT.E12	NT.F10	hca2_on_allo	100	0	No	No	No	No	5	7
5	NT.D14	NT.K16	hca2_on_allo	100	0	No	No	Yes	No	5	4
6	5x34	NT.K16	hca2_on_allo	100	0	No	No	Yes	No	1	4
7	5x38	NT.K16	hca2_on_allo	100	0	No	No	Yes	No	2	4
8	1x27	E1.W91	hca2_on_allo	100	0	Yes	No	Yes	Yes	3	4
9	1x27	E1x49	hca2_on_allo	100	0	Yes	No	No	No	3	4
10	1x28	1x30	hca2_on_allo	100	0	No	No	No	No	4	6
11	1x31	E1.W91	hca2_on_allo	100	0	Yes	No	Yes	Yes	5	4
12	1x42	7x47	hca2_on_allo	100	0	Yes	No	Yes	No	7	8
13	1x56	8x50	hca2_on_allo	100	0	No	No	Yes	No	7	9
14	1x57	I1.L56	hca2_on_allo	100	0	Yes	No	No	No	7	5
15	1x57	2x40	hca2_on_allo	100	0	Yes	No	Yes	No	7	7
16	1x57	8x50	hca2_on_allo	100	0	Yes	No	Yes	No	7	9
17	2x40	8x47	hca2_on_allo	100	0	Yes	No	No	No	7	8
18	2x40	8x50	hca2_on_allo	100	0	Yes	No	Yes	No	7	9
19	2x43	3x46	hca2_on_allo	100	0	No	No	No	No	8	9
20	2x43	7x53	hca2_on_allo	100	0	No	No	Yes	Yes	8	9
21	2x46	2x50	hca2_on_allo	100	0	Yes	No	Yes	Yes	9	9
22	2x46	3x43	hca2_on_allo	100	0	Yes	No	No	No	9	9
23	2x46	7x53	hca2_on_allo	100	0	Yes	No	Yes	Yes	9	9
24	2x52	3x31	hca2_on_allo	100	0	No	No	No	No	6	5
25	2x60	3x28	hca2_on_allo	100	0	Yes	No	No	No	6	5
26	2x60	7x42	hca2_on_allo	100	0	Yes	No	Yes	Yes	6	7
27	E1.W91	E2.L176	hca2_on_allo	100	0	Yes	Yes	Yes	Yes	4	4
28	3x25	E2.M167	hca2_on_allo	100	0	No	No	No	No	9	3
29	3x28	3x32	hca2_on_allo	100	0	No	No	Yes	No	5	6
30	3x29	E2x50	hca2_on_allo	100	0	No	No	No	No	5	9
31	3x30	4x58	hca2_on_allo	100	0	Yes	No	No	No	6	4
32	3x32	7x42	hca2_on_allo	100	0	Yes	No	Yes	Yes	6	7
33	3x36	E2.F180	hca2_on_allo	100	0	Yes	No	Yes	Yes	8	3
34	3x36	7x42	hca2_on_allo	100	0	Yes	No	Yes	Yes	8	7
35	3x40	6x44	hca2_on_allo	100	0	No	No	Yes	Yes	8	9
36	3x42	4x46	hca2_on_allo	100	0	Yes	No	No	Yes	8	8
37	3x43	7x49	hca2_on_allo	100	0	No	No	Yes	Yes	9	9
38	4x56	5x39	hca2_on_allo	100	0	No	No	No	No	5	5
39	4x59	4x63	hca2_on_allo	100	0	Yes	No	No	No	7	4
40	4x59	5x40	hca2_on_allo	100	0	Yes	No	Yes	No	7	5
41	4x60	5x40	hca2_on_allo	100	0	No	No	Yes	No	4	5
42	E2.N175	E2.P168	hca2_on_allo	100	0	No	No	No	No	4	4
43	E2.F180	E2x52	hca2_on_allo	100	0	Yes	Yes	Yes	No	3	4
44	5x41	E2.F180	hca2_on_allo	100	0	Yes	No	Yes	Yes	4	3
45	5x33	6x62	hca2_on_allo	100	0	Yes	No	No	No	3	3
46	5x35	Alloh56	hca2_on_allo	100	0	No	No	Yes	No	3	0
47	5x37	Alloh56	hca2_on_allo	100	0	No	No	Yes	No	4	0
48	5x41	Alloh56	hca2_on_allo	100	0	Yes	No	Yes	No	4	0
49	5x44	7x34	hca2_on_allo	100	0	No	No	Yes	Yes	6	4
50	5x45	6x59	hca2_on_allo	100	0	No	No	Yes	No	4	5
51	5x45	Alloh56	hca2_on_allo	100	0	No	No	Yes	No	4	0
52	5x48	6x52	hca2_on_allo	100	0	No	No	No	No	5	8
53	5x49	5x53	hca2_on_allo	100	0	No	No	No	No	4	7
54	6x59	Alloh56	hca2_on_allo	100	0	Yes	No	Yes	No	5	0
55	6x61	7x30	hca2_on_allo	100	0	No	No	No	No	3	4
56	6x62	Alloh56	hca2_on_allo	100	0	No	No	Yes	No	3	0
57	7x37	7x40	hca2_on_allo	100	0	No	No	No	No	7	7
58	7x41	7x42	hca2_on_allo	100	0	No	No	Yes	Yes	8	7
59	7x54	8x50	hca2_on_allo	100	0	Yes	Yes	Yes	No	7	9
60	3x44	5x54	hca2_on_allo	50	0	No	No	No	No	7	8
61	1x39	7x39	hca2_on_allo	50	0	No	No	No	No	8	6
62	2x59	E1x52	hca2_on_allo	50	0	No	No	Yes	No	6	7
63	7x40	7x43	hca2_on_allo	50	0	No	No	No	No	7	5
64	5x62	6x37	hca2_on_allo	50	0	No	No	No	No	5	7
65	6x30	I3.M220	hca2_on_allo	50	0	No	No	No	No	6	3
66	3x52	I2x55	hca2_on_allo	0	0	Yes	Yes	No	No	5	4
67	1x46	7x47	hca2_on_allo	0	0	No	No	Yes	No	8	8
68	1x39	2x60	hca2_on_allo	50	0	No	No	Yes	No	8	6
69	3x48	5x57	hca2_on_allo	0	0	No	No	No	No	6	8
70	1x25	5x32	hca2_on_allo	0	0	No	No	No	No	2	4
71	5x46	Alloh56	hca2_on_allo	0	0	No	No	Yes	No	4	0
72	1x60	8x51	hca2_on_allo	0	0	No	Yes	No	No	5	8
73	2x42	4x45	hca2_on_allo	50	0	No	No	No	No	7	5
74	2x48	4x50	hca2_on_allo	50	0	No	No	Yes	No	6	9
75	3x45	4x49	hca2_on_allo	0	0	No	No	No	No	7	7
76	3x24	E1x52	hca2_on_allo	0	0	No	No	Yes	No	5	7
77	7x32	7x36	hca2_on_allo	50	0	Yes	No	No	No	1	6
78	1x31	7x32	hca2_on_allo	0	0	Yes	No	Yes	No	5	1
79	7x47	7x48	hca2_on_allo	0	0	Yes	No	No	No	8	7
80	1x36	2x64	hca2_on_allo	0	0	No	No	Yes	Yes	6	6
81	7x24	7x27	hca2_on_allo	0	0	No	No	Yes	Yes	7	2
82	2x38	2x42	hca2_on_allo	50	0	No	No	No	No	6	7
83	5x42	Alloh56	hca2_on_allo	0	0	No	No	Yes	No	3	0
84	3x54	5x64	hca2_on_allo	0	0	No	No	No	No	8	5
85	5x35	E3.G262	hca2_on_allo	0	0	No	No	No	No	3	4
86	6x34	6x38	hca2_on_allo	0	0	No	No	No	No	6	4
87	4x44	4x48	hca2_on_allo	0	0	No	No	No	No	3	4
88	5x58	6x41	hca2_on_allo	0	0	No	No	No	No	8	7
89	6x43	6x47	hca2_on_allo	0	0	No	No	No	No	7	8
90	3x33	4x57	hca2_on_allo	0	0	No	No	No	No	4	7
91	5x53	5x57	hca2_on_allo	0	0	No	No	No	No	7	8
92	E3.G262	E3.Q264	hca2_on_allo	0	0	No	No	No	No	4	3
93	6x35	6x39	hca2_on_allo	0	0	No	No	No	No	6	5
94	6x60	6x63	hca2_on_allo	0	0	No	No	No	No	4	1
95	E1x50	E2.P168	hca2_on_allo	0	0	Yes	Yes	No	No	9	4
96	I1.K57	I1.S58	hca2_on_allo	0	0	No	No	No	No	5	6
97	1x26	NT.H9	Shared	100	100	No	Yes	No	No	2	6
98	NT.F10	NT.N17	Shared	100	100	No	No	No	No	7	5
99	E2.N171	NT.L11	Shared	100	100	No	No	No	No	1	8
100	E2.I169	NT.I13	Shared	100	100	No	No	No	No	1	3
101	5x36	NT.K16	Shared	100	100	No	No	Yes	No	2	4
102	5x34	NT.C18	Shared	100	100	No	No	No	No	1	9
103	7x24	NT.C19	Shared	100	100	No	No	No	No	7	4
104	1x25	E2.L176	Shared	100	100	No	No	Yes	Yes	2	4
105	1x26	7x28	Shared	100	100	No	Yes	No	No	2	1
106	1x26	7x31	Shared	100	100	No	Yes	No	No	2	4
107	1x27	2x67	Shared	100	100	Yes	No	No	No	3	4
108	1x27	E2.A174	Shared	100	100	Yes	No	No	No	3	2
109	1x28	7x32	Shared	100	100	No	No	Yes	No	4	1
110	1x29	2x67	Shared	100	100	No	No	No	No	4	4
111	1x30	7x32	Shared	100	100	No	No	Yes	No	6	1
112	1x31	1x35	Shared	100	100	Yes	No	No	No	5	5
113	1x31	2x64	Shared	100	100	Yes	No	Yes	Yes	5	6
114	1x34	7x36	Shared	100	10	No	No	No	No	5	6
115	1x35	2x64	Shared	100	100	No	No	Yes	Yes	5	6
116	1x36	1x37	Shared	100	100	No	No	No	No	6	5
117	1x36	2x65	Shared	100	70	No	No	No	No	6	3
118	1x39	2x61	Shared	100	40	No	No	No	No	8	7
119	1x42	7x42	Shared	100	100	Yes	No	Yes	Yes	7	7
120	1x42	7x43	Shared	100	100	Yes	No	No	No	7	5
121	1x43	1x47	Shared	100	100	No	No	No	No	7	7
122	1x43	2x57	Shared	100	50	No	No	No	No	7	8
123	1x43	2x58	Shared	100	100	No	No	No	No	7	8
124	1x45	7x47	Shared	100	100	No	No	Yes	No	6	8
125	1x46	2x54	Shared	100	100	No	No	No	No	8	6
126	1x49	7x50	Shared	100	40	No	No	No	Yes	7	9
127	1x50	2x50	Shared	100	100	No	No	Yes	Yes	9	9
128	1x50	7x50	Shared	100	100	No	No	No	Yes	9	9
129	1x52	7x55	Shared	100	100	No	No	No	No	6	8
130	1x53	7x54	Shared	100	40	No	No	Yes	Yes	9	7
131	1x54	2x51	Shared	100	100	No	No	No	No	7	7
132	1x55	1x59	Shared	100	100	No	No	No	No	4	4
133	1x55	1x60	Shared	100	100	No	No	No	Yes	4	5
134	1x56	1x60	Shared	100	40	No	No	No	Yes	7	5
135	1x57	2x44	Shared	100	100	Yes	No	Yes	Yes	7	6
136	1x57	7x54	Shared	100	100	Yes	No	Yes	Yes	7	7
137	1x58	1x59	Shared	100	100	No	No	No	No	4	4
138	2x41	I1.W59	Shared	100	100	No	No	No	No	7	6
139	2x44	I1.W59	Shared	100	100	Yes	Yes	No	No	6	6
140	2x38	I2x57	Shared	100	100	No	No	No	No	6	7
141	2x39	3x49	Shared	100	100	No	No	No	No	8	8
142	2x40	8x49	Shared	100	10	Yes	No	No	No	7	5
143	2x41	4x39	Shared	100	100	No	No	No	No	7	2
144	2x41	4x42	Shared	100	100	No	No	No	No	7	7
145	2x42	3x45	Shared	100	100	No	No	No	No	7	7
146	2x43	7x54	Shared	100	100	No	No	Yes	Yes	8	7
147	2x44	2x48	Shared	100	100	Yes	Yes	No	No	6	6
148	2x45	3x42	Shared	100	100	No	No	Yes	No	9	8
149	2x45	4x46	Shared	100	100	No	No	No	Yes	9	8
150	2x45	4x50	Shared	100	100	No	No	Yes	No	9	9
151	2x46	7x54	Shared	100	100	Yes	No	Yes	Yes	9	7
152	2x47	7x54	Shared	100	100	No	No	Yes	Yes	8	7
153	2x50	3x39	Shared	100	60	Yes	Yes	No	No	9	9
154	2x50	7x46	Shared	100	100	Yes	Yes	No	No	9	8
155	2x50	7x49	Shared	100	100	Yes	Yes	Yes	Yes	9	9
156	2x51	2x55	Shared	100	100	No	No	No	No	7	6
157	2x52	3x35	Shared	100	100	No	No	No	Yes	6	9
158	2x53	7x42	Shared	100	100	No	No	Yes	Yes	7	7
159	2x53	7x46	Shared	100	100	No	No	No	No	7	8
160	2x57	7x42	Shared	100	100	No	No	Yes	Yes	8	7
161	2x60	2x64	Shared	100	100	Yes	No	Yes	Yes	6	6
162	2x60	3x32	Shared	100	100	Yes	No	Yes	No	6	6
163	2x62	2x66	Shared	100	100	No	No	No	Yes	4	4
164	2x62	E1x52	Shared	100	100	No	No	Yes	No	4	7
165	2x63	E1.W91	Shared	100	100	No	No	Yes	Yes	5	4
166	2x63	E1x50	Shared	100	100	No	No	Yes	Yes	5	9
167	2x64	E1.W91	Shared	100	100	Yes	Yes	Yes	Yes	6	4
168	2x66	E1x49	Shared	100	100	No	Yes	No	No	4	4
169	2x66	E1x51	Shared	100	100	No	Yes	No	No	4	3
170	E1.W91	E2x51	Shared	100	100	Yes	Yes	No	Yes	4	4
171	7x35	E1.W91	Shared	100	100	No	No	Yes	Yes	5	4
172	E1x50	E1x52	Shared	100	100	Yes	Yes	Yes	No	9	7
173	3x25	E1x50	Shared	100	100	No	No	Yes	Yes	9	9
174	3x28	E1x50	Shared	100	100	No	No	Yes	Yes	5	9
175	E1x50	E2x50	Shared	100	100	Yes	Yes	No	No	9	9
176	3x21	3x24	Shared	100	20	No	No	No	No	7	5
177	3x22	3x26	Shared	100	100	No	No	No	No	3	6
178	3x23	3x26	Shared	100	100	No	No	No	No	2	6
179	3x25	E2x50	Shared	100	100	No	No	No	No	9	9
180	3x29	E2x52	Shared	100	100	No	No	Yes	No	5	4
181	3x30	3x34	Shared	100	100	Yes	No	Yes	Yes	6	5
182	3x30	4x57	Shared	100	100	Yes	No	No	No	6	7
183	3x30	4x61	Shared	100	100	Yes	No	No	No	6	5
184	3x31	3x35	Shared	100	100	No	No	No	Yes	5	9
185	3x32	Lig	Shared	100	100	Yes	No	Yes	Yes	6	0
186	3x34	3x35	Shared	100	100	Yes	Yes	No	Yes	5	9
187	3x34	4x53	Shared	100	100	Yes	Yes	No	Yes	5	7
188	3x34	4x54	Shared	100	100	Yes	Yes	No	No	5	4
189	3x34	4x57	Shared	100	100	Yes	Yes	No	No	5	7
190	3x36	5x461	Shared	100	100	Yes	No	No	Yes	8	5
191	3x36	7x41	Shared	100	100	Yes	No	No	No	8	8
192	3x36	Lig	Shared	100	100	Yes	No	Yes	Yes	8	0
193	3x37	4x53	Shared	100	100	Yes	Yes	No	Yes	7	7
194	3x37	4x56	Shared	100	100	Yes	Yes	No	No	7	5
195	3x37	5x43	Shared	100	100	Yes	Yes	No	No	7	5
196	3x37	5x461	Shared	100	100	Yes	Yes	No	Yes	7	5
197	3x40	5x461	Shared	100	100	No	No	No	Yes	8	5
198	3x40	6x48	Shared	100	100	No	No	Yes	Yes	8	8
199	3x41	4x49	Shared	100	100	No	No	No	No	5	7
200	3x42	4x49	Shared	100	100	Yes	No	No	No	8	7
201	3x42	4x50	Shared	100	100	Yes	No	Yes	No	8	9
202	3x43	7x53	Shared	100	100	No	No	Yes	Yes	9	9
203	3x44	5x50	Shared	100	100	No	No	No	No	7	9
204	3x44	5x53	Shared	100	100	No	No	No	No	7	7
205	3x46	3x50	Shared	100	100	No	No	No	No	9	9
206	3x49	3x53	Shared	100	100	No	No	No	No	8	8
207	3x50	7x53	Shared	100	100	No	No	Yes	Yes	9	9
208	3x51	3x52	Shared	100	100	Yes	Yes	Yes	Yes	7	5
209	3x51	3x55	Shared	100	100	Yes	Yes	Yes	Yes	7	8
210	3x51	3x56	Shared	100	100	Yes	Yes	Yes	Yes	7	7
211	3x51	5x56	Shared	100	100	Yes	Yes	No	No	7	4
212	3x51	5x57	Shared	100	100	Yes	Yes	No	No	7	8
213	3x51	5x60	Shared	100	100	Yes	Yes	Yes	Yes	7	4
214	3x52	3x56	Shared	100	100	Yes	Yes	Yes	Yes	5	7
215	3x52	I2x52	Shared	100	100	Yes	Yes	No	No	5	4
216	3x52	I2x54	Shared	100	100	Yes	Yes	No	No	5	4
217	3x54	5x61	Shared	100	100	No	No	No	No	8	8
218	3x55	3x56	Shared	100	100	Yes	Yes	Yes	Yes	8	7
219	3x55	5x60	Shared	100	100	Yes	Yes	Yes	Yes	8	4
220	3x55	5x64	Shared	100	100	Yes	Yes	No	No	8	5
221	I2x50	I2x51	Shared	100	100	No	No	No	No	8	6
222	4x41	I2x57	Shared	100	100	No	No	No	No	3	7
223	4x38	4x41	Shared	100	100	No	No	No	No	6	3
224	4x40	4x44	Shared	100	30	No	No	No	No	4	3
225	4x59	4x60	Shared	100	100	Yes	No	No	No	7	4
226	4x59	5x39	Shared	100	100	Yes	No	No	No	7	5
227	E2.I169	E2.L176	Shared	100	100	No	No	Yes	Yes	1	4
228	E2.L176	E2.N171	Shared	100	100	Yes	Yes	No	No	4	1
229	E2.L176	E2x51	Shared	100	100	Yes	Yes	No	Yes	4	4
230	5x40	E2x52	Shared	100	100	Yes	No	Yes	No	5	4
231	E2x52	Lig	Shared	100	100	Yes	No	Yes	Yes	4	0
232	5x40	E2.F180	Shared	100	100	Yes	No	Yes	Yes	5	3
233	5x44	E2.F180	Shared	100	100	No	No	Yes	Yes	6	3
234	7x34	E2.F180	Shared	100	100	Yes	Yes	Yes	Yes	4	3
235	E2.F180	Lig	Shared	100	100	Yes	Yes	Yes	Yes	3	0
236	5x33	6x58	Shared	100	100	Yes	No	No	No	3	4
237	5x33	7x27	Shared	100	100	Yes	No	Yes	Yes	3	2
238	5x33	7x31	Shared	100	100	Yes	No	No	No	3	4
239	5x35	E3.T263	Shared	100	100	No	No	No	No	3	3
240	5x38	5x41	Shared	100	100	No	No	Yes	No	2	4
241	5x39	5x43	Shared	100	100	No	No	No	No	5	5
242	5x41	6x55	Shared	100	100	Yes	No	Yes	Yes	4	5
243	5x41	6x59	Shared	100	100	Yes	No	Yes	No	4	5
244	5x44	6x51	Shared	100	100	No	No	No	No	6	6
245	5x47	5x48	Shared	100	100	Yes	Yes	No	No	8	5
246	5x47	5x51	Shared	100	100	Yes	Yes	No	Yes	8	7
247	5x47	6x44	Shared	100	100	Yes	Yes	Yes	Yes	8	9
248	5x47	6x49	Shared	100	100	Yes	Yes	No	No	8	6
249	5x47	6x52	Shared	100	100	Yes	Yes	No	No	8	8
250	5x51	5x55	Shared	100	100	No	Yes	No	No	7	4
251	5x54	6x44	Shared	100	50	No	No	Yes	Yes	8	9
252	5x56	5x60	Shared	100	100	No	No	Yes	Yes	4	4
253	5x62	5x66	Shared	100	100	No	No	No	No	5	4
254	5x62	6x34	Shared	100	100	No	No	No	No	5	6
255	5x63	5x67	Shared	100	100	No	No	No	No	3	5
256	5x65	6x30	Shared	100	30	No	Yes	No	No	8	6
257	5x65	6x34	Shared	100	100	No	Yes	No	No	8	6
258	5x66	I3.D221	Shared	100	100	No	No	No	No	4	3
259	I3.M220	I3.R218	Shared	100	100	No	No	No	No	3	5
260	6x27	6x29	Shared	100	100	No	No	No	No	4	5
261	6x27	6x30	Shared	100	100	No	No	No	No	4	6
262	6x32	6x36	Shared	100	100	No	No	No	Yes	7	7
263	6x36	7x56	Shared	100	100	No	Yes	No	No	7	6
264	6x40	7x53	Shared	100	100	No	No	Yes	Yes	8	9
265	6x44	6x48	Shared	100	100	Yes	Yes	Yes	Yes	9	8
266	6x47	7x45	Shared	100	100	No	No	No	No	8	9
267	6x48	7x41	Shared	100	100	Yes	Yes	No	No	8	8
268	6x48	7x45	Shared	100	100	Yes	Yes	No	No	8	9
269	6x54	7x37	Shared	100	100	No	No	No	No	5	7
270	6x55	6x58	Shared	100	100	Yes	Yes	No	No	5	4
271	6x55	6x59	Shared	100	100	Yes	Yes	Yes	No	5	5
272	6x55	7x34	Shared	100	100	Yes	Yes	Yes	Yes	5	4
273	6x57	6x61	Shared	100	100	No	No	No	No	5	3
274	6x58	7x30	Shared	100	100	No	No	No	No	4	4
275	6x60	6x64	Shared	100	100	No	No	No	No	4	1
276	6x61	7x27	Shared	100	100	No	No	Yes	Yes	3	2
277	6x62	7x27	Shared	100	100	No	No	Yes	Yes	3	2
278	7x25	7x28	Shared	100	100	Yes	No	No	No	2	1
279	7x31	7x35	Shared	100	100	No	No	No	No	4	5
280	7x34	7x35	Shared	100	100	Yes	Yes	No	No	4	5
281	7x38	Lig	Shared	100	100	No	No	Yes	Yes	5	0
282	7x42	Lig	Shared	100	100	Yes	Yes	Yes	Yes	7	0
283	7x45	7x49	Shared	100	100	No	No	Yes	Yes	9	9
284	7x49	7x53	Shared	100	100	Yes	Yes	Yes	Yes	9	9
285	7x50	7x55	Shared	100	50	No	Yes	No	No	9	8
286	7x53	7x54	Shared	100	100	Yes	Yes	Yes	Yes	9	7
287	7x26	7x27	Shared	50	100	No	No	Yes	Yes	1	2
288	7x52	7x53	Shared	50	40	No	No	Yes	Yes	8	9
289	1x44	1x45	Shared	50	40	No	No	No	No	5	6
290	1x41	1x45	Shared	50	30	No	No	No	No	4	6
291	1x54	2x44	Shared	50	60	No	No	Yes	Yes	7	6
292	3x38	4x53	Shared	0	50	No	No	No	Yes	7	7
293	3x53	I2x55	Shared	50	100	No	No	No	No	8	4
294	6x50	7x40	Shared	50	20	No	No	No	No	9	7
295	5x45	6x56	Shared	50	10	No	No	No	No	4	6
296	8x47	8x48	Shared	0	50	No	No	No	No	8	5
297	3x23	3x24	Shared	0	100	No	No	No	No	2	5
298	6x54	7x33	Shared	0	0	No	No	No	No	5	5
299	E2.N175	E2.Q170	Shared	0	100	No	No	No	No	4	1
300	1x32	2x67	Shared	50	100	No	No	No	No	3	4
301	2x56	3x31	Shared	50	100	No	No	No	No	6	5
302	6x39	7x52	Shared	0	20	No	No	No	No	5	8
303	1x30	1x33	Shared	50	40	No	No	No	No	6	3
304	5x58	6x37	Shared	0	30	No	No	No	No	8	7
305	4x58	4x62	Shared	0	10	No	No	No	No	4	4
306	3x54	5x65	Shared	0	100	No	No	No	Yes	8	8
307	6x45	6x49	Shared	0	10	No	No	No	No	5	6
308	6x49	6x53	Shared	0	0	No	No	No	No	6	6
309	6x32	8x48	Shared	50	100	No	No	No	No	7	5
310	1x38	1x42	Shared	0	100	No	No	Yes	No	5	7
311	3x23	3x27	Shared	0	0	No	No	No	No	2	5
312	4x52	4x56	Shared	0	10	No	No	No	No	5	5
313	4x51	4x54	Shared	0	20	No	No	No	No	4	4
314	7x23	7x25	Shared	0	100	No	No	Yes	No	5	2
315	1x40	2x61	Shared	0	60	No	No	No	No	5	7
316	2x49	4x50	Shared	0	20	No	No	Yes	No	8	9
317	6x26	I3.Q219	Shared	0	40	No	No	No	No	3	3
318	E2.G172	E2.G173	Shared	0	0	No	No	No	No	3	4
319	3x22	4x64	Shared	50	100	No	No	No	No	3	4
320	E3.G262	E3.S261	Shared	0	50	No	No	No	No	4	3
321	4x55	4x58	Shared	0	50	No	No	No	No	5	4
322	1x48	1x49	Shared	0	10	No	No	No	No	4	7
323	5x51	5x52	Shared	0	10	No	Yes	No	No	7	3
324	6x46	6x47	Shared	0	0	No	No	No	No	5	8
325	3x47	5x54	Shared	0	0	No	No	No	No	9	8
326	6x64	E3.S261	Shared	0	40	No	No	No	No	1	3
327	3x56	I2x50	Shared	0	0	Yes	Yes	No	No	7	8
328	5x60	5x63	Shared	0	100	Yes	Yes	No	No	4	3
329	6x42	6x46	Shared	0	10	No	No	No	No	5	5
330	E3.T263	NT.N17	Shared	0	100	No	No	No	No	3	5
331	4x38	4x40	Shared	0	20	No	No	No	No	6	4
332	7x51	7x55	Shared	0	20	No	No	No	No	6	8
333	1x51	1x54	Shared	0	0	No	No	No	No	4	7
334	7x29	7x30	Shared	0	10	No	No	No	No	3	4
335	1x28	7x28	hca2_on	0	100	No	No	No	No	4	1
336	I1.L56	I1.W59	hca2_on	0	100	No	No	No	No	5	6
337	2x37	I1.S58	hca2_on	0	100	No	No	No	No	7	6
338	2x39	3x53	hca2_on	0	100	No	No	No	No	8	8
339	2x46	7x49	hca2_on	0	100	Yes	No	Yes	Yes	9	9
340	2x53	3x35	hca2_on	0	100	No	No	No	Yes	7	9
341	2x56	3x32	hca2_on	0	100	No	No	Yes	No	6	6
342	2x60	Lig	hca2_on	0	100	Yes	No	Yes	Yes	6	0
343	2x64	Lig	hca2_on	0	100	Yes	Yes	Yes	Yes	6	0
344	E1x49	E1x51	hca2_on	0	100	No	No	No	No	4	3
345	E1x49	E2.A174	hca2_on	0	100	No	No	No	No	4	2
346	3x22	E2.P168	hca2_on	0	100	No	No	No	No	3	4
347	3x25	E2.P168	hca2_on	0	100	No	No	No	No	9	4
348	3x26	E2.M167	hca2_on	0	100	No	No	No	No	6	3
349	3x40	5x50	hca2_on	0	100	No	No	No	No	8	9
350	I2x52	I2x55	hca2_on	0	100	No	No	No	No	4	4
351	E2x51	Lig	hca2_on	0	100	No	Yes	Yes	Yes	4	0
352	5x44	5x461	hca2_on	0	100	No	No	No	Yes	6	5
353	5x49	5x50	hca2_on	0	100	No	No	No	No	4	9
354	5x51	6x44	hca2_on	0	100	No	Yes	Yes	Yes	7	9
355	6x35	6x36	hca2_on	0	100	No	No	No	Yes	6	7
356	6x43	7x48	hca2_on	0	100	No	No	No	No	7	7
357	6x50	7x37	hca2_on	0	100	No	No	No	No	9	7
358	6x51	7x37	hca2_on	0	100	No	No	No	No	6	7
359	6x54	7x34	hca2_on	0	100	No	No	Yes	Yes	5	4
360	7x27	7x30	hca2_on	0	100	Yes	Yes	No	No	2	4
361	7x50	7x54	hca2_on	0	100	No	Yes	Yes	Yes	9	7
362	NT.I13	NT.L11	hca2_on	0	100	No	No	No	No	3	8
363	1x27	E2.N171	hca2_on	0	100	Yes	No	No	No	3	1
364	3x29	Lig	hca2_on	0	100	No	No	Yes	Yes	5	0
365	5x35	6x62	hca2_on	0	100	No	No	No	No	3	3
366	5x36	5x38	hca2_on	0	100	No	No	No	No	2	2
367	7x34	7x38	hca2_on	0	100	Yes	Yes	No	No	4	5
368	7x43	7x47	hca2_on	0	100	No	No	Yes	No	5	8
369	1x39	7x42	hca2_on	0	30	No	No	Yes	Yes	8	7
370	1x50	2x54	hca2_on	0	50	No	No	No	No	9	6
371	NT.C18	NT.I13	hca2_on	0	50	No	No	No	No	9	3
372	2x59	3x28	hca2_on	0	40	No	No	No	No	6	5
373	5x65	I3.M220	hca2_on	0	40	No	Yes	No	No	8	3
374	5x61	6x37	hca2_on	0	50	No	No	No	No	8	7
375	1x38	7x39	hca2_on	0	30	No	No	No	No	5	6
376	4x63	NT.D14	hca2_on	0	40	No	No	No	No	4	5
377	4x45	4x49	hca2_on	0	30	No	No	No	No	5	7
378	1x26	NT.C19	hca2_on	0	40	No	Yes	No	No	2	4
379	3x41	4x53	hca2_on	0	30	No	No	No	Yes	5	7
380	7x43	7x48	hca2_on	0	40	No	No	No	No	5	7
381	E2.I169	NT.D14	hca2_on	0	20	No	No	No	No	1	5
382	5x62	6x38	hca2_on	0	40	No	No	No	No	5	4
383	6x57	6x60	hca2_on	0	10	No	No	No	No	5	4
384	2x65	2x66	hca2_on	0	40	No	No	No	Yes	3	4
385	E2	Lig	hca2_on	0	20	No	No	Yes	Yes	0	0
386	2x40	I1.L56	hca2_on	0	40	Yes	No	No	No	7	5
387	2x38	4x42	hca2_on	0	30	No	No	No	No	6	7
388	5x45	6x52	hca2_on	0	20	No	No	No	No	4	8
389	5x32	E2x51	hca2_on	0	30	No	No	No	Yes	4	4
390	2x42	4x46	hca2_on	0	10	No	No	No	Yes	7	8
391	3x48	3x52	hca2_on	0	10	No	No	Yes	Yes	6	5
392	3x33	Lig	hca2_on	0	30	No	No	Yes	Yes	4	0
393	3x51	5x61	hca2_on	0	20	Yes	Yes	No	No	7	8
394	E1x50	E2.N175	hca2_on	0	20	Yes	Yes	No	No	9	4
395	1x35	7x36	hca2_on	0	10	No	No	No	No	5	6
396	4x54	4x55	hca2_on	0	40	No	No	No	No	4	5
397	7x23	E3.Q264	hca2_on	0	20	No	No	No	No	5	3
398	NT.D14	NT.E12	hca2_on	0	20	No	No	No	No	5	5
399	1x60	8x53	hca2_on	0	10	No	Yes	No	No	5	0
400	6x31	I3.D221	hca2_on	0	20	No	No	No	No	4	3
401	4x48	4x52	hca2_on	0	20	No	No	No	No	4	5
402	1x52	1x56	hca2_on	0	20	No	No	No	No	6	7
403	3x50	6x37	hca2_on	0	20	No	No	No	No	9	7
404	6x36	6x39	hca2_on	0	30	No	Yes	No	No	7	5
405	5x37	5x42	hca2_on	0	10	No	No	No	No	4	3
406	6x63	6x64	hca2_on	0	20	No	No	No	No	1	1
407	5x54	6x41	hca2_on	0	0	No	No	No	No	8	7
408	4x63	NT.K15	hca2_on	0	20	No	No	No	No	4	3
409	8x49	8x50	hca2_on	0	20	No	No	Yes	No	5	9
410	6x26	I3.D221	hca2_on	0	10	No	No	No	No	3	3
411	5x37	6x59	hca2_on	0	20	No	No	Yes	No	4	5
412	E2.G172	E2.Q170	hca2_on	0	10	No	No	No	No	3	1
413	NT.D8	NT.F10	hca2_on	0	10	No	No	No	No	6	7
414	5x46	5x49	hca2_on	0	10	No	No	No	No	4	4
415	NT.Q7	NT.R3	hca2_on	0	10	No	No	No	No	0	0
416	1x60	I1.K57	hca2_on	0	10	No	Yes	No	No	5	5
417	NT.D8	NT.H5	hca2_on	0	10	No	No	No	No	6	0
418	3x52	I2x56	hca2_on	0	10	Yes	Yes	No	No	5	4
419	NT.L6	NT.R3	hca2_on	0	10	No	No	No	No	0	0
420	2x40	I1.S58	hca2_on	0	10	Yes	No	No	No	7	6
421	6x27	6x28	hca2_on	0	0	No	No	No	No	4	3
422	I2x52	I2x53	hca2_on	0	0	No	No	No	No	4	5
423	7x25	NT.L6	hca2_on	0	10	Yes	No	No	No	2	0
424	NT.H5	NT.M1	hca2_on	0	10	No	No	No	No	0	0
425	4x43	4x46	hca2_on	0	0	No	No	No	Yes	3	8
426	4x46	4x47	hca2_on	0	0	No	Yes	No	No	8	4
427	5x58	5x59	hca2_on	0	0	No	No	No	No	8	3
428	6x30	6x33	hca2_on	0	0	No	No	No	No	6	7
429	8x56	8x57	hca2_on	0	0	No	No	No	No	0	0
430	8x50	8x51	hca2_on	0	0	Yes	No	No	No	9	8
431	1x56	8x57	hca2_on	0	0	No	No	No	No	7	0
432	8x54	8x55	hca2_on	0	0	No	No	No	No	0	0
433	NT.H4	NT.L6	hca2_on	0	0	No	No	No	No	0	0

Orange: nodes, hubs and links specific of hca2_on_allo network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of hca2_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	hca2_on_allo Avg Int. Strength	hca2_on Avg Int. Strength	hca2_on_allo Num Of Links	hca2_on Num Of Links	ConSurf
1	NT.K16	hca2_on_allo	100	0	4	1	4
2	1x27	hca2_on_allo	50	20	4	3	3
3	1x31	hca2_on_allo	0	10	4	2	5
4	1x42	hca2_on_allo	0	50	4	3	7
5	1x57	hca2_on_allo	100	40	5	2	7
6	2x40	hca2_on_allo	50	0	4	3	7
7	2x46	hca2_on_allo	50	50	4	2	9
8	2x60	hca2_on_allo	50	30	5	3	6
9	E1x52	hca2_on_allo	0	0	4	2	7
10	3x30	hca2_on_allo	100	50	4	3	6
11	3x32	hca2_on_allo	50	30	4	3	6
12	3x36	hca2_on_allo	100	40	5	3	8
13	3x42	hca2_on_allo	50	50	4	3	8
14	4x50	hca2_on_allo	0	10	4	3	9
15	4x59	hca2_on_allo	50	0	4	2	7
16	E2x52	hca2_on_allo	50	30	4	3	4
17	5x33	hca2_on_allo	100	20	4	3	3
18	5x40	hca2_on_allo	100	60	4	2	5
19	5x41	hca2_on_allo	100	40	5	3	4
20	6x59	hca2_on_allo	100	0	4	3	5
21	7x25	hca2_on_allo	0	0	4	3	2
22	7x32	hca2_on_allo	0	0	4	2	1
23	7x47	hca2_on_allo	0	0	4	2	8
24	8x50	hca2_on_allo	100	20	4	2	9
25	Alloh56	hca2_on_allo	100	0	8	0	0
26	2x44	Shared	50	30	4	4	6
27	2x50	Shared	100	60	5	4	9
28	2x64	Shared	100	90	5	5	6
29	E1.W91	Shared	100	80	7	4	4
30	E1x50	Shared	100	90	6	6	9
31	3x34	Shared	100	60	5	5	5
32	3x37	Shared	100	30	4	4	7
33	3x51	Shared	100	100	6	7	7
34	3x52	Shared	50	30	5	6	5
35	3x55	Shared	50	60	4	4	8
36	3x56	Shared	0	0	4	4	7
37	E2.L176	Shared	100	30	5	4	4
38	E2.F180	Shared	100	60	7	4	3
39	5x47	Shared	100	90	5	5	8
40	5x60	Shared	0	20	4	4	4
41	6x44	Shared	100	50	4	4	9
42	6x48	Shared	100	90	4	4	8
43	6x55	Shared	100	90	4	4	5
44	7x27	Shared	50	80	5	5	2
45	7x34	Shared	100	100	4	5	4
46	7x42	Shared	100	90	8	5	7
47	7x49	Shared	100	80	4	4	9
48	7x53	Shared	100	100	8	6	9
49	7x54	Shared	100	90	7	7	7
50	Lig	Shared	100	90	6	12	0
51	1x26	hca2_on	0	50	3	4	2
52	1x60	hca2_on	0	0	3	4	5
53	2x66	hca2_on	0	0	3	4	4
54	3x35	hca2_on	0	30	3	4	9
55	4x46	hca2_on	0	0	2	4	8
56	4x53	hca2_on	0	0	3	4	7
57	E2x51	hca2_on	0	0	2	4	4
58	5x461	hca2_on	0	20	3	4	5
59	5x51	hca2_on	0	10	3	4	7
60	5x65	hca2_on	0	0	3	4	8
61	6x36	hca2_on	0	30	2	4	7
62	7x50	hca2_on	0	30	3	4	9

Orange: nodes, hubs and links specific of hca2_on_allo network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of hca2_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	hca2_on_allo Recurrence	hca2_on Recurrence	hca2_on_allo Hub1?	hca2_on Hub1?	hca2_on_allo Hub2?	hca2_on Hub2?	ConSurf1	ConSurf2
1	1x26	NT.H9	hca2_on_allo	11.6977	2.35061	No	Yes	No	No	2	6
2	6x62	Alloh56	hca2_on_allo	20.2477	0	No	No	Yes	No	3	0
3	5x35	Alloh56	hca2_on_allo	33.4797	0	No	No	Yes	No	3	0
4	E1.W91	E2.L176	hca2_on_allo	13.3406	0	Yes	Yes	Yes	Yes	4	4
5	5x41	6x55	hca2_on_allo	18.3877	5.54606	Yes	No	Yes	Yes	4	5
6	5x38	5x41	hca2_on_allo	17.0901	4.18828	No	No	Yes	No	2	4
7	5x38	NT.K16	hca2_on_allo	14.2089	0	No	No	Yes	No	2	4
8	5x41	Alloh56	hca2_on_allo	58.4341	0	Yes	No	Yes	No	4	0
9	5x41	E2.F180	hca2_on_allo	90.7494	0	Yes	No	Yes	Yes	4	3
10	1x27	E1.W91	hca2_on_allo	15.541	0	Yes	No	Yes	Yes	3	4
11	1x31	7x32	hca2_on_allo	10.9774	0	Yes	No	Yes	No	5	1
12	2x60	2x64	hca2_on_allo	39.8145	0.373569	Yes	No	Yes	Yes	6	6
13	1x42	7x42	hca2_on_allo	31.7431	8.40386	Yes	No	Yes	Yes	7	7
14	2x60	7x42	hca2_on_allo	64.2163	0	Yes	No	Yes	Yes	6	7
15	3x36	7x42	hca2_on_allo	43.4851	0	Yes	No	Yes	Yes	8	7
16	3x36	E2.F180	hca2_on_allo	100	0	Yes	No	Yes	Yes	8	3
17	1x42	7x43	hca2_on_allo	12.9607	5.91244	Yes	No	No	No	7	5
18	1x42	7x47	hca2_on_allo	15.0871	0	Yes	No	Yes	No	7	8
19	2x46	2x50	hca2_on_allo	78.588	0	Yes	No	Yes	Yes	9	9
20	1x56	1x60	hca2_on_allo	11.7125	5.27306	No	No	No	Yes	7	5
21	1x56	8x50	hca2_on_allo	14.0115	0	No	No	Yes	No	7	9
22	7x54	8x50	hca2_on_allo	29.4884	0	Yes	Yes	Yes	No	7	9
23	1x57	2x40	hca2_on_allo	15.388	0	Yes	No	Yes	No	7	7
24	2x40	8x50	hca2_on_allo	14.6529	0	Yes	No	Yes	No	7	9
25	2x38	2x42	hca2_on_allo	15.9653	0	No	No	No	No	6	7
26	2x42	3x45	hca2_on_allo	20.524	0.77731	No	No	No	No	7	7
27	3x45	4x49	hca2_on_allo	22.7934	0	No	No	No	No	7	7
28	3x42	4x49	hca2_on_allo	27.3077	6.90383	Yes	No	No	No	8	7
29	3x42	4x50	hca2_on_allo	31.7085	1.53594	Yes	No	Yes	No	8	9
30	2x48	4x50	hca2_on_allo	40.3671	0	No	No	Yes	No	6	9
31	2x44	2x48	hca2_on_allo	42.5675	3.18108	Yes	Yes	No	No	6	6
32	3x51	5x57	hca2_on_allo	62.6178	1.39226	Yes	Yes	No	No	7	8
33	5x53	5x57	hca2_on_allo	66.1404	0	No	No	No	No	7	8
34	3x44	5x53	hca2_on_allo	69.6236	0.617825	No	No	No	No	7	7
35	3x44	5x54	hca2_on_allo	73.0672	0	No	No	No	No	7	8
36	5x54	6x44	hca2_on_allo	76.2939	2.73855	No	No	Yes	Yes	8	9
37	3x40	6x44	hca2_on_allo	26.2322	0	No	No	Yes	Yes	8	9
38	3x36	5x461	hca2_on_allo	44.0772	4.27305	Yes	No	No	Yes	8	5
39	2x40	8x47	hca2_on_allo	21.7919	0	Yes	No	No	No	7	8
40	3x34	4x53	hca2_on_allo	26.173	6.0044	Yes	Yes	No	Yes	5	7
41	3x37	4x53	hca2_on_allo	29.7548	8.80041	Yes	Yes	No	Yes	7	7
42	2x60	3x28	hca2_on_allo	21.8166	0	Yes	No	No	No	6	5
43	3x28	E1x50	hca2_on_allo	44.8813	2.24429	No	No	Yes	Yes	5	9
44	E1x50	E1x52	hca2_on_allo	33.011	7.59494	Yes	Yes	Yes	No	9	7
45	3x24	E1x52	hca2_on_allo	20.3365	0	No	No	Yes	No	5	7
46	3x23	3x24	hca2_on_allo	14.574	2.47561	No	No	No	No	2	5
47	5x40	E2.F180	hca2_on_allo	10.6172	0.987083	Yes	No	Yes	Yes	5	3
48	3x51	3x55	hca2_on_allo	34.5947	2.76153	Yes	Yes	Yes	Yes	7	8
49	3x54	5x64	hca2_on_allo	32.1328	0	No	No	No	No	8	5
50	3x55	5x64	hca2_on_allo	33.8399	1.39945	Yes	Yes	No	No	8	5
51	5x47	6x44	hca2_on_allo	18.4666	7.69982	Yes	Yes	Yes	Yes	8	9
52	5x62	6x34	hca2_on_allo	12.6055	9.68548	No	No	No	No	5	6
53	5x65	6x30	hca2_on_allo	10.2768	6.65958	No	Yes	No	No	8	6
54	6x32	8x48	hca2_on_allo	12.862	2.50435	No	No	No	No	7	5
55	8x47	8x48	hca2_on_allo	17.3516	1.39226	No	No	No	No	8	5
56	7x40	7x43	hca2_on_allo	10.8244	0	No	No	No	No	7	5
57	E3.G262	E3.S261	hca2_on_allo	12.4278	4.80323	No	No	No	No	4	3
58	5x35	E3.G262	hca2_on_allo	18.585	0	No	No	No	No	3	4
59	3x28	3x32	hca2_on_allo	25.4971	0	No	No	Yes	No	5	6
60	7x41	7x42	hca2_on_allo	35.7245	0	No	No	Yes	Yes	8	7
61	3x32	7x42	hca2_on_allo	21.6094	0	Yes	No	Yes	Yes	6	7
62	1x26	7x28	Shared	11.6977	26.292	No	Yes	No	No	2	1
63	1x26	7x31	Shared	26.094	35.1126	No	Yes	No	No	2	4
64	5x35	E3.T263	Shared	12.4278	26.2403	No	No	No	No	3	3
65	7x31	7x35	Shared	33.9435	76.1548	No	No	No	No	4	5
66	7x35	E1.W91	Shared	27.8652	37.3353	No	No	Yes	Yes	5	4
67	6x55	6x58	Shared	25.428	46.1745	Yes	Yes	No	No	5	4
68	7x34	7x35	Shared	38.1124	43.8383	Yes	Yes	No	No	4	5
69	6x55	7x34	Shared	21.9991	56.4591	Yes	Yes	Yes	Yes	5	4
70	7x34	E2.F180	Shared	44.6544	60.9362	Yes	Yes	Yes	Yes	4	3
71	2x64	E1.W91	Shared	27.8997	31.1369	Yes	Yes	Yes	Yes	6	4
72	7x42	Lig	Shared	37.2391	90.4266	Yes	Yes	Yes	Yes	7	0
73	E2.F180	Lig	Shared	35.8182	41.7089	Yes	Yes	Yes	Yes	3	0
74	1x50	7x50	Shared	13.3159	24.4213	No	No	No	Yes	9	9
75	1x50	2x50	Shared	15.5015	26.1627	No	No	Yes	Yes	9	9
76	2x50	7x46	Shared	93.7491	85.5515	Yes	Yes	No	No	9	8
77	2x53	7x46	Shared	94.7111	85.8604	No	No	No	No	7	8
78	2x53	7x42	Shared	95.9495	85.5515	No	No	Yes	Yes	7	7
79	2x46	7x54	Shared	71.8042	34.3554	Yes	No	Yes	Yes	9	7
80	7x53	7x54	Shared	41.6794	37.4833	Yes	Yes	Yes	Yes	9	7
81	7x49	7x53	Shared	56.1744	100	Yes	Yes	Yes	Yes	9	9
82	7x45	7x49	Shared	58.3601	77.9336	No	No	Yes	Yes	9	9
83	6x48	7x45	Shared	62.8003	79.7095	Yes	Yes	No	No	8	9
84	6x48	7x41	Shared	79.1652	62.5181	Yes	Yes	No	No	8	8
85	3x36	7x41	Shared	43.8403	62.8156	Yes	No	No	No	8	8
86	1x57	2x44	Shared	61.6015	69.5671	Yes	No	Yes	Yes	7	6
87	1x57	7x54	Shared	77.8775	72.0643	Yes	No	Yes	Yes	7	7
88	2x38	I2x57	Shared	13.6662	15.8824	No	No	No	No	6	7
89	3x51	3x52	Shared	14.0658	13.21	Yes	Yes	Yes	Yes	7	5
90	3x40	5x461	Shared	36.5435	25.0248	No	No	No	Yes	8	5
91	6x44	6x48	Shared	66.4858	14.1697	Yes	Yes	Yes	Yes	9	8
92	3x37	5x461	Shared	38.2111	12.6812	Yes	Yes	No	Yes	7	5
93	4x41	I2x57	Shared	11.6878	12.7114	No	No	No	No	3	7
94	5x65	6x34	Shared	16.2366	11.0519	No	Yes	No	No	8	6
95	3x54	5x65	Shared	28.1415	21.6612	No	No	No	Yes	8	8
96	6x58	7x30	Shared	17.4306	23.4184	No	No	No	No	4	4
97	6x62	7x27	Shared	12.3588	35.8123	No	No	Yes	Yes	3	2
98	2x50	7x49	Shared	10.336	61.4994	Yes	Yes	Yes	Yes	9	9
99	3x40	6x48	Shared	10.2472	24.542	No	No	Yes	Yes	8	8
100	E2.L176	E2x51	hca2_on	0.0296019	15.0117	Yes	Yes	No	Yes	4	4
101	E1.W91	E2x51	hca2_on	1.67744	32.239	Yes	Yes	No	Yes	4	4
102	5x33	7x31	hca2_on	9.67981	40.3655	Yes	No	No	No	3	4
103	5x33	7x27	hca2_on	2.156	58.2508	Yes	No	Yes	Yes	3	2
104	5x35	6x62	hca2_on	0	31.0277	No	No	No	No	3	3
105	E3.T263	NT.N17	hca2_on	9.33445	21.45	No	No	No	No	3	5
106	NT.F10	NT.N17	hca2_on	6.23119	16.6568	No	No	No	No	7	5
107	5x33	6x58	hca2_on	5.57995	21.9328	Yes	No	No	No	3	4
108	7x27	7x30	hca2_on	0	20.6828	Yes	Yes	No	No	2	4
109	2x63	E1x50	hca2_on	7.38566	28.5708	No	No	Yes	Yes	5	9
110	2x63	E1.W91	hca2_on	6.94164	29.7289	No	No	Yes	Yes	5	4
111	2x64	Lig	hca2_on	0	32.9818	Yes	Yes	Yes	Yes	6	0
112	E2x51	Lig	hca2_on	0	43.8282	No	Yes	Yes	Yes	4	0
113	7x38	Lig	hca2_on	2.47175	40.9072	No	No	Yes	Yes	5	0
114	7x34	7x38	hca2_on	0	40.4287	Yes	Yes	No	No	4	5
115	7x50	7x55	hca2_on	6.69989	10.3091	No	Yes	No	No	9	8
116	1x54	2x44	hca2_on	9.31965	12.6726	No	No	Yes	Yes	7	6
117	2x46	7x49	hca2_on	0	35.5594	Yes	No	Yes	Yes	9	9
118	7x50	7x54	hca2_on	0	18.6195	No	Yes	Yes	Yes	9	7
119	3x36	Lig	hca2_on	5.86117	67.1389	Yes	No	Yes	Yes	8	0
120	5x44	5x461	hca2_on	0	22.7848	No	No	No	Yes	6	5
121	5x44	E2.F180	hca2_on	4.52415	21.69	No	No	Yes	Yes	6	3
122	I1.L56	I1.W59	hca2_on	0	20.3293	No	No	No	No	5	6
123	2x44	I1.W59	hca2_on	9.38872	51.1976	Yes	Yes	No	No	6	6
124	2x40	I1.L56	hca2_on	0	17.164	Yes	No	No	No	7	5
125	2x41	I1.W59	hca2_on	7.05511	28.5378	No	No	No	No	7	6
126	2x38	4x42	hca2_on	0	19.0506	No	No	No	No	6	7
127	2x41	4x42	hca2_on	2.35828	22.2158	No	No	No	No	7	7
128	3x51	5x61	hca2_on	0	27.838	Yes	Yes	No	No	7	8
129	5x61	6x37	hca2_on	0	50.9217	No	No	No	No	8	7
130	3x50	6x37	hca2_on	0	54.4936	No	No	No	No	9	7
131	3x50	7x53	hca2_on	4.69683	56.5037	No	No	Yes	Yes	9	9
132	2x53	3x35	hca2_on	0	12.7243	No	No	No	Yes	7	9
133	3x25	E1x50	hca2_on	4.97805	12.2545	No	No	Yes	Yes	9	9
134	3x25	E2.P168	hca2_on	0	11.0548	No	No	No	No	9	4
135	3x34	3x35	hca2_on	7.67181	10.9183	Yes	Yes	No	Yes	5	9
136	3x54	5x61	hca2_on	2.1264	23.0104	No	No	No	No	8	8
137	7x52	7x53	hca2_on	7.88889	10.5188	No	No	Yes	Yes	8	9
138	6x57	6x61	hca2_on	6.25586	28.7835	No	No	No	No	5	3
139	6x61	7x27	hca2_on	4.95831	33.5709	No	No	Yes	Yes	3	2
140	6x57	6x60	hca2_on	0	23.9932	No	No	No	No	5	4
141	6x60	6x64	hca2_on	6.23119	19.2	No	No	No	No	4	1
142	7x25	7x28	hca2_on	8.78682	14.6554	Yes	No	No	No	2	1
143	NT.D8	NT.F10	hca2_on	0	11.8579	No	No	No	No	6	7

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
1x31	1x35	Shared	4.709	8.565	1	1	2	2
1x35	2x64	Shared	10.08	17.58	1	1	2	1
1x42	7x42	Shared	5.499	4.49	0	0	2	1
2x53	7x42	Shared	3.281	5.86	0	0	2	1
2x56	3x32	hca2_on	3.808	0	0	0	2	1
2x57	7x42	Shared	4.922	7.03	0	0	2	1
2x60	2x64	Shared	6.916	5.86	1	1	1	1
2x60	3x32	Shared	4.153	7.61	1	1	1	1
2x60	Lig	hca2_on	5.63	0	1	1	1	0
2x64	E1.W91	Shared	6.366	13.02	1	1	1	2
2x64	Lig	hca2_on	4.486	0	1	1	1	0
E1.W91	E2x51	Shared	3.336	4.325	0	1	2	1
3x29	E2x52	Shared	3.302	9.01	1	0	1	1
3x32	Lig	Shared	9.181	10.1	1	1	1	0
3x36	5x461	Shared	5.349	6.975	0	1	1	2
3x36	7x41	Shared	5.045	5.82	0	1	1	2
3x36	Lig	Shared	8.802	9.48	0	1	1	0
E2.L176	E2x51	Shared	3.453	7.51	0	1	2	1
E2x51	Lig	hca2_on	3.487	0	0	1	1	0
5x40	E2x52	Shared	6.137	6.975	0	1	2	1
E2x52	Lig	Shared	6.869	9.115	1	1	1	0
5x40	E2.F180	Shared	5.882	11.315	0	1	2	1
5x44	E2.F180	Shared	6.002	12.325	0	1	2	1
7x34	E2.F180	Shared	6.323	12.86	0	1	2	1
E2.F180	Lig	Shared	7.701	11.59	0	1	1	0
5x44	5x461	hca2_on	3.615	0	0	1	2	2
7x38	Lig	Shared	6.366	6.005	0	0	1	0
7x42	Lig	Shared	7.991	7.59	0	1	1	0
1x31	2x64	Shared	3.75	4.235	1	1	2	1
3x29	Lig	hca2_on	5.05	0	1	0	1	0
7x34	7x38	hca2_on	6.335	0	0	1	2	1
1x39	7x42	hca2_on	3.163	0	0	0	2	1
E2	Lig	hca2_on	2.485	0	0	0	1	0
5x32	E2x51	hca2_on	2.282	0	0	0	2	1
3x33	Lig	hca2_on	2.202	0	0	0	1	0
1x31	E1.W91	hca2_on_allo	0	7.05	1	1	2	2
2x60	3x28	hca2_on_allo	0	5.65	1	1	1	2
2x60	7x42	hca2_on_allo	0	4.105	1	1	1	1
E1.W91	E2.L176	hca2_on_allo	0	4.56	0	1	2	2
3x28	3x32	hca2_on_allo	0	4.24	0	1	2	1
3x29	E2x50	hca2_on_allo	0	4.76	1	0	1	2
3x32	7x42	hca2_on_allo	0	6.445	1	1	1	1
3x36	E2.F180	hca2_on_allo	0	4.275	0	1	1	1
3x36	7x42	hca2_on_allo	0	4.115	0	1	1	1
E2.F180	E2x52	hca2_on_allo	0	3.96	0	1	1	1
5x41	E2.F180	hca2_on_allo	0	4.66	8	1	2	1
5x44	7x34	hca2_on_allo	0	5.36	0	1	2	2
7x41	7x42	hca2_on_allo	0	5.62	0	1	2	1
1x39	2x60	hca2_on_allo	0	3.46	0	0	2	1
1x36	2x64	hca2_on_allo	0	2.78	0	0	2	1
3x33	4x57	hca2_on_allo	0	1.68	0	0	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	hca2_on_allo	8J6P-HCA₂-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA₂-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
	hca2_on	8H2G-HCA₂-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA₂-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA₂-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA₂-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA₂-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA₂-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA₂-MMF-Gi1/&β;1/&γ;2 8IJB-HCA₂-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA₂-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA₂-GSK256073-Gi1/&β;1/&γ;2

Network Difference
Value	hca2_on_allo	hca2_on
I_min	3.825	3.177
Number of Linked Nodes	287	308
Number of Specific Nodes	1 (0.35%)	22 (7.14%)
Number of Shared Nodes	286 (99.65%)	286 (92.86%)
Number of Links	334	337
Number of Specific Links	96 (28.74%)	99 (29.38%)
Number of Shared Links	238 (71.26%)	238 (70.62%)
Number of Hubs	50	37
Number of Specific Hubs	25 (50.00%)	12 (32.43%)
Number of Shared Hubs	25 (50.00%)	25 (67.57%)
Average % Shared Neighbours (Jaccard)	57.36
Average % Shared Neighbours (Otsuka)	66.54
Average % Shared Neighbours (Overlap Coefficient)	76.37
Average % Shared Cliques (k3-6)	80.23
Graphlets Similarity	0.582135

Paths Difference
Value	hca2_on_allo	hca2_on
Number Of Nodes in MetaPath	91	74
Specific Nodes in MetaPath	43 (47.25%)	26 (35.14%)
Shared Nodes in MetaPath	286 (99.65%)	286 (99.65%)
Number Of Links MetaPath	99	82
Specific Links in MetaPath	61 (61.62%)	44 (53.66%)
Shared Links in MetaPath	238 (71.26%)	238 (71.26%)
Number of Shortest Paths	72773	159413
Length Of Smallest Path	3	3
Average Path Length	12.9437	16.9535
Length of Longest Path	35	33
Minimum Path Strength	1.555	0.257
Average Path Strength	6.81628	5.39593
Maximum Path Strength	20.285	13.3435
Minimum Path Correlation	0.7	0.701
Average Path Correlation	0.916931	0.911432
Maximum Path Correlation	0.99	0.99
Minimum % Of Corr. Nodes	3.84615	3.44828
Average % Of Corr. Nodes	46.5235	34.0273
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	51.6901	42.0133
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

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