Orange: nodes, hubs and links specific of histamine_on_gp network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of histamine_off network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.


Index Hub Owner histamine_on_gp Avg Int. Strength histamine_off Avg Int. Strength histamine_on_gp Num Of Links histamine_off Num Of Links ConSurf
1b.lh12x2 histamine_on_gp00408
2b.h2x1 histamine_on_gp500405
3b.lhb1x6 histamine_on_gp600503
4b.l1x3 histamine_on_gp1000609
5b.l1x6 histamine_on_gp00409
6b.b2x1 histamine_on_gp400408
7b.b2x5 histamine_on_gp950407
8b.l3x2 histamine_on_gp850409
9b.b4x6 histamine_on_gp1000709
10b.b5x2 histamine_on_gp00407
11b.b5x3 histamine_on_gp950709
12b.b5x5 histamine_on_gp650405
13b.l5x1 histamine_on_gp750508
14b.l5x5 histamine_on_gp1000709
15b.b6x5 histamine_on_gp900506
16b.b7x1 histamine_on_gp500404
17b.b8x3 histamine_on_gp700406
18b.b8x4 histamine_on_gp1000606
19b.l8x5 histamine_on_gp00403
20b.l8x8 histamine_on_gp500404
21b.l9x3 histamine_on_gp950509
22b.l9x6 histamine_on_gp1000808
23b.b10x5 histamine_on_gp700609
24b.l10x1 histamine_on_gp350403
25b.b11x4 histamine_on_gp650409
26b.b11x5 histamine_on_gp350406
27b.l11x2 histamine_on_gp1000409
28b.b12x6 histamine_on_gp1000608
29b.l12x1 histamine_on_gp00406
30b.b13x7 histamine_on_gp1000507
31b.l13x3 histamine_on_gp1000609
32b.l13x6 histamine_on_gp750609
33b.l13x7 histamine_on_gp850409
34b.b14x3 histamine_on_gp950405
35b.b15x1 histamine_on_gp1000409
36b.l15x1 histamine_on_gp750507
37b.l15x2 histamine_on_gp700509
38b.b16x4 histamine_on_gp750406
39b.b16x5 histamine_on_gp150405
40b.b16x6 histamine_on_gp1000508
41b.b16x7 histamine_on_gp350409
42b.b17x5 histamine_on_gp850507
43b.b17x7 histamine_on_gp850408
44b.l17x3 histamine_on_gp1000709
45b.l17x6 histamine_on_gp650509
46b.b18x3 histamine_on_gp650408
47b.b18x5 histamine_on_gp750405
48b.l18x1 histamine_on_gp950706
49b.b19x2 histamine_on_gp750606
50b.b19x4 histamine_on_gp1000408
51b.l19x2 histamine_on_gp950509
52b.b20x2 histamine_on_gp500406
53b.b20x4 histamine_on_gp1000608
54b.b20x6 histamine_on_gp750506
55b.b20x7 histamine_on_gp250409
56b.l20x2 histamine_on_gp250409
57b.b21x1 histamine_on_gp650607
58b.b21x2 histamine_on_gp00406
59b.b21x7 histamine_on_gp900605
60b.l21x7 histamine_on_gp00405
61b.b22x5 histamine_on_gp650507
62b.l22x5 histamine_on_gp1000509
63b.b23x1 histamine_on_gp250405
64b.b23x3 histamine_on_gp250407
65b.b23x6 histamine_on_gp1000707
66b.l23x1 histamine_on_gp700406
67b.b24x4 histamine_on_gp450406
68b.b24x6 histamine_on_gp650508
69b.l24x2 histamine_on_gp250406
70b.b25x3 histamine_on_gp00405
71b.l25x3 histamine_on_gp1000509
72b.b26x3 histamine_on_gp650506
73b.l26x1 histamine_on_gp250407
74b.l27x1 histamine_on_gp1000609
75b.l27x2 histamine_on_gp500409
76b.b28x3 histamine_on_gp750507
77b.b28x4 histamine_on_gp700406
78b.b28x6 histamine_on_gp1000509
79g.h1x11 histamine_on_gp00609
80g.h1x14 histamine_on_gp250409
81g.l1x4 histamine_on_gp500408
82g.h2x9 histamine_on_gp00404
83g.ctx3 histamine_on_gp1000509
84g.ctx6 histamine_on_gp500506
85g.ctx14 histamine_on_gp250409
86g.ctx15 histamine_on_gp600409
87g.ctx16 histamine_on_gp1000608
881x46 histamine_on_gp00429
892x40 histamine_on_gp500439
902x43 histamine_on_gp450429
912x46 histamine_on_gp5533.3333439
922x53 histamine_on_gp500439
932x60 histamine_on_gp750528
942x61 histamine_on_gp00428
952x65 histamine_on_gp00436
963x28 histamine_on_gp7533.3333439
973x32 histamine_on_gp5033.3333439
983x33 histamine_on_gp7533.3333539
993x43 histamine_on_gp00429
1003x46 histamine_on_gp00419
1013x50 histamine_on_gp066.6667439
1024x50 histamine_on_gp650439
1035x51 histamine_on_gp250539
1045x57 histamine_on_gp700537
1055x68 histamine_on_gp250438
1066x29 histamine_on_gp300518
1076x30 histamine_on_gp250538
1086x41 histamine_on_gp033.3333439
1096x52 histamine_on_gp500439
1106x58 histamine_on_gp250416
111E3 histamine_on_gp450634
1127x49 histamine_on_gp150439
1137x53 histamine_on_gp9566.6667439
1148x47 histamine_on_gp450529
1158x50 histamine_on_gp7033.3333539
116G.HN.11 histamine_on_gp00402
117G.S1.02 histamine_on_gp750405
118G.S1.06 histamine_on_gp250408
119G.H1.01 histamine_on_gp250409
120G.H1.04 histamine_on_gp500407
121G.S2.03 histamine_on_gp300409
122G.S2.06 histamine_on_gp250408
123G.S3.01 histamine_on_gp500404
124G.S3.03 histamine_on_gp700407
125G.S3.05 histamine_on_gp250407
126G.S3.06 histamine_on_gp750506
127G.S3.07 histamine_on_gp00409
128G.s3h2.03 histamine_on_gp100409
129G.H2.03 histamine_on_gp400409
130G.H2.06 histamine_on_gp1000509
131G.H2.07 histamine_on_gp1000509
132G.H2.09 histamine_on_gp00508
133G.h2s4.01 histamine_on_gp1000509
134G.S4.04 histamine_on_gp450509
135G.S4.06 histamine_on_gp50407
136G.s4h3.01 histamine_on_gp200407
137G.s4h3.04 histamine_on_gp750608
138G.H3.01 histamine_on_gp00409
139G.H3.09 histamine_on_gp950609
140G.H3.13 histamine_on_gp450505
141G.H3.17 histamine_on_gp750605
142G.H3.18 histamine_on_gp400409
143G.S5.04 histamine_on_gp350408
144G.S5.05 histamine_on_gp950609
145G.S5.06 histamine_on_gp650408
146G.S5.07 histamine_on_gp250409
147G.HG.04 histamine_on_gp450408
148G.HG.14 histamine_on_gp00505
149G.hgh4.02 histamine_on_gp700408
150G.hgh4.05 histamine_on_gp600406
151G.H4.03 histamine_on_gp400605
152G.H4.15 histamine_on_gp700409
153G.S6.02 histamine_on_gp750608
154G.S6.04 histamine_on_gp250509
155G.S6.05 histamine_on_gp400405
156G.s6h5.01 histamine_on_gp500609
157G.s6h5.02 histamine_on_gp00407
158G.s6h5.05 histamine_on_gp500609
159G.H5.03 histamine_on_gp400508
160G.H5.08 histamine_on_gp500508
161G.H5.20 histamine_on_gp500408
162G.h4s6.02 histamine_on_gp250400
163I3 histamine_on_gp500500
164NT Shared00445
1652x42 Shared7533.3333478
1662x50 Shared9033.3333549
1672x57 Shared6566.6667659
168E1x50 Shared7566.6667859
1693x37 Shared6566.6667449
170I2x53 Shared500449
1714x57 Shared6566.6667558
172E2 Shared10010018115
1735x47 Shared7533.3333649
1745x58 Shared500449
1756x44 Shared8066.6667649
1766x48 Shared100100669
1776x51 Shared100100769
1787x38 Shared7533.3333448
1797x39 Shared60100579
1807x42 Shared75100869
1818x54 Shared2533.3333459
182Lig Shared1001009110
1832x56 histamine_off033.3333349
1843x51 histamine_off450349
185I2x52 histamine_off033.3333345
186I2x57 histamine_off033.3333159
1875x39 histamine_off300349
1885x54 histamine_off5033.3333349
1896x31 histamine_off033.3333247
1907x34 histamine_off150347
1917x45 histamine_off066.6667359
   
Orange: nodes, hubs and links specific of histamine_on_gp network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of histamine_off network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Owner histamine_on_gp Recurrence histamine_off Recurrence histamine_on_gp Hub1? histamine_off Hub1? histamine_on_gp Hub2? histamine_off Hub2? ConSurf1 ConSurf2
1b.1x15 b.1x19 histamine_on_gp10.15070NoNoNoNo76
2b.1x19 b.b21x1 histamine_on_gp15.81530NoNoYesNo67
3b.b16x5 b.b17x5 histamine_on_gp13.27150YesNoYesNo57
4b.b16x5 b.b17x4 histamine_on_gp23.63290YesNoNoNo55
5b.b17x2 b.b17x4 histamine_on_gp17.57070NoNoNoNo35
6b.b17x2 g.h1x13 histamine_on_gp15.5510NoNoNoNo31
7g.h1x13 g.h1x9 histamine_on_gp14.54040NoNoNoNo16
8g.h1x12 g.h1x9 histamine_on_gp13.52980NoNoNoNo66
9g.h1x12 g.h1x8 histamine_on_gp12.51910NoNoNoNo67
10b.1x4 g.h1x8 histamine_on_gp10.49760NoNoNoNo87
11b.b17x7 b.b21x1 histamine_on_gp31.08940YesNoYesNo87
12b.b17x7 b.b20x6 histamine_on_gp58.34630YesNoYesNo86
13b.b19x4 b.b20x6 histamine_on_gp24.3920YesNoYesNo86
14b.b19x4 b.l17x3 histamine_on_gp30.50310YesNoYesNo89
15b.l17x3 b.l19x2 histamine_on_gp56.21940YesNoYesNo99
16b.l17x5 b.l19x2 histamine_on_gp82.07540NoNoYesNo69
17b.l17x5 b.l17x6 histamine_on_gp82.18360NoNoYesNo69
18b.l15x1 b.l17x6 histamine_on_gp55.39670YesNoYesNo79
19b.l13x6 b.l15x1 histamine_on_gp28.38950YesNoYesNo97
20b.l23x1 b.l25x6 histamine_on_gp12.1170YesNoNoNo68
21b.l21x7 b.l23x1 histamine_on_gp11.66480YesNoYesNo56
22b.b23x6 b.l21x7 histamine_on_gp10.75170YesNoYesNo75
23b.b20x4 b.b20x6 histamine_on_gp48.77110YesNoYesNo86
24b.b20x4 b.l17x3 histamine_on_gp25.13820YesNoYesNo89
25b.b20x2 b.b20x4 histamine_on_gp25.13340YesNoYesNo68
26b.b20x2 b.l19x2 histamine_on_gp25.42820YesNoYesNo69
27b.l13x6 b.l9x6 histamine_on_gp27.27670YesNoYesNo98
28b.b14x1 b.l15x1 histamine_on_gp27.08370NoNoYesNo87
29b.b14x1 b.l9x6 histamine_on_gp54.35280NoNoYesNo88
30G.H2.06 b.l17x6 histamine_on_gp27.04280YesNoYesNo99
31G.H2.06 b.b14x1 histamine_on_gp27.2370YesNoNoNo98
32G.H2.09 b.l27x1 histamine_on_gp16.9560YesNoYesNo89
33b.b21x1 g.h1x14 histamine_on_gp13.10330YesNoYesNo79
34b.b17x6 g.h1x14 histamine_on_gp22.77530NoNoYesNo79
35b.b16x4 b.b17x6 histamine_on_gp21.93270YesNoNoNo67
36b.b16x4 b.b16x6 histamine_on_gp10.35590YesNoYesNo68
37b.b26x1 b.l27x1 histamine_on_gp11.21650NoNoYesNo99
38b.b26x1 b.b26x2 histamine_on_gp11.15070NoNoNoNo97
39b.b26x2 b.b2x3 histamine_on_gp11.08770NoNoNoNo76
40b.b2x3 b.b3x2 histamine_on_gp11.0250NoNoNoNo65
41b.l7x2 b.l9x6 histamine_on_gp79.88670NoNoYesNo98
42b.l5x5 b.l7x2 histamine_on_gp79.9040YesNoNoNo99
43G.h2s4.01 b.l5x5 histamine_on_gp80.28050YesNoYesNo99
44b.b16x5 b.l20x1 histamine_on_gp17.48750YesNoNoNo56
45b.b19x2 b.l20x1 histamine_on_gp18.0430YesNoNoNo66
463x43 7x53 histamine_on_gp40.95770YesNoYesNo99
473x50 7x53 histamine_on_gp41.01380YesNoYesNo99
483x50 G.H5.25 histamine_on_gp43.89360YesNoNoNo98
49G.H5.20 G.H5.25 histamine_on_gp75.24150YesNoNoNo88
50G.H5.20 G.H5.26 histamine_on_gp75.47720YesNoNoNo88
516x29 G.H5.26 histamine_on_gp75.59070YesNoNoNo88
526x29 6x30 histamine_on_gp76.00010YesNoYesNo88
535x68 6x30 histamine_on_gp76.70276.20421YesNoYesNo88
545x68 G.H5.13 histamine_on_gp76.77290YesNoNoNo87
55G.H5.13 G.S6.02 histamine_on_gp76.83180NoNoYesNo78
56G.H5.06 G.S6.02 histamine_on_gp77.27790NoNoYesNo48
57G.H5.06 G.S6.04 histamine_on_gp77.33570NoNoYesNo49
58G.S6.04 G.s6h5.05 histamine_on_gp80.65320YesNoYesNo99
59G.s6h5.02 G.s6h5.05 histamine_on_gp92.65490YesNoYesNo79
60G.HG.01 G.s6h5.02 histamine_on_gp92.74280NoNoYesNo57
61G.H4.03 G.HG.01 histamine_on_gp92.87020YesNoNoNo55
62G.H4.03 G.HG.04 histamine_on_gp93.92810YesNoYesNo58
63G.HG.04 G.s4h3.01 histamine_on_gp94.98140YesNoYesNo87
64G.S5.06 G.s4h3.01 histamine_on_gp95.53950YesNoYesNo87
65G.S4.06 G.S5.06 histamine_on_gp47.83680YesNoYesNo78
66G.S4.04 G.S4.06 histamine_on_gp48.74430YesNoYesNo97
67G.S1.07 G.S4.04 histamine_on_gp99.8750NoNoYesNo99
68G.S1.05 G.S1.07 histamine_on_gp1000NoNoNoNo99
69G.S1.05 G.h2s4.01 histamine_on_gp99.99210NoNoYesNo99
703x36 6x48 histamine_on_gp20.5590.789816NoNoYesYes99
717x42 Lig histamine_on_gp17.93170YesYesYesYes90
723x36 Lig histamine_on_gp14.15820.763835NoNoYesYes90
737x41 Lig histamine_on_gp14.15810NoNoYesYes90
746x48 7x41 histamine_on_gp18.39221.57963YesYesNoNo99
755x47 6x44 histamine_on_gp19.89060YesYesYesYes99
765x54 6x44 histamine_on_gp29.77460NoYesYesYes99
775x54 5x58 histamine_on_gp29.67280NoYesYesYes99
786x37 G.H5.25 histamine_on_gp31.31610NoNoNoNo98
79G.S5.04 G.S5.06 histamine_on_gp48.2110YesNoYesNo88
80G.S4.04 G.S5.04 histamine_on_gp48.70770YesNoYesNo98
81G.S2.06 G.S3.05 histamine_on_gp11.93040YesNoYesNo87
82G.S5.03 G.S5.05 histamine_on_gp10.22780NoNoYesNo89
832x60 3x28 histamine_on_gp12.11630YesNoYesNo89
843x33 E2 histamine_on_gp15.6280YesNoYesYes95
85G.H2.09 G.H2.10 histamine_on_gp19.0670YesNoNoNo87
86b.b17x5 b.b17x7 histamine_on_gp26.87620YesNoYesNo78
87b.b19x2 b.b20x6 histamine_on_gp14.39960YesNoYesNo66
88b.b17x5 g.h1x14 histamine_on_gp13.0830YesNoYesNo79
89G.H2.10 G.h2s4.01 histamine_on_gp19.07620NoNoYesNo79
906x44 6x48 Shared39.079428.5061YesYesYesYes99
913x43 6x44 Shared30.152369.4414YesNoYesYes99
926x52 Lig Shared14.182428.7088YesNoYesYes90
935x47 6x52 Shared18.718425.6846YesYesYesNo99
945x58 6x37 Shared31.246923.4191YesYesNoNo99
952x57 7x42 Shared11.82329.6337YesYesYesYes99
963x33 Lig Shared18.805422.7851YesNoYesYes90
977x39 7x42 histamine_off9.7361931.125YesYesYesYes99
982x56 7x42 histamine_off0.0022668213.6607NoYesYesYes99
992x56 3x28 histamine_off023.8815NoYesYesNo99
1003x28 E1x50 histamine_off9.0865119.9013YesNoYesYes99
101E1x50 E1x52 histamine_off1.968812.9488YesYesNoNo99
1022x62 E1x52 histamine_off011.4731NoNoNoNo69
1032x62 2x66 histamine_off010.2001NoNoNoNo65
1041x50 7x50 histamine_off0.3132110.6365NoNoNoNo99
1051x50 2x50 histamine_off1.4085215.708NoNoYesYes99
1062x50 7x46 histamine_off7.2465323.788YesYesNoNo99
1072x53 7x46 histamine_off7.0946623.6477YesNoNoNo99
1082x53 2x56 histamine_off0.15529325.2065YesNoNoYes99
1098x50 8x54 histamine_off0.58005836.1548YesNoYesYes99
1108x50 I1x50 histamine_off0.67965946.9265YesNoNoNo99
1112x40 I1x50 histamine_off0.0008539449.3115YesNoNoNo99
1122x40 2x43 histamine_off051.9096YesNoYesNo99
1132x43 7x53 histamine_off053.1826YesNoYesNo99
1142x46 7x53 histamine_off055.5001YesNoYesNo99
1152x46 7x49 histamine_off0.00349339100YesNoYesNo99
1162x50 7x49 histamine_off4.4566536.0249YesYesYesNo99
1171x53 8x54 histamine_off011.3588NoNoYesYes99
1181x56 8x54 histamine_off0.085083511.1042NoNoYesYes99
1192x42 4x46 histamine_off049.5453YesYesNoNo89
1202x45 4x46 histamine_off0.080534353.4269NoNoNoNo99
1212x45 3x42 histamine_off0.78449159.6882NoNoNoNo98
1222x46 3x42 histamine_off1.6204460.9093YesNoNoNo98
1232x54 2x57 histamine_off0.75944811.3432NoNoYesYes99
1242x56 3x32 histamine_off0.15574317.511NoYesYesNo99
125E2 E2x52 histamine_off0.0029344520.6807YesYesNoNo59
1263x33 E2x52 histamine_off0.90992721.9174YesNoNoNo99
1273x32 Lig histamine_off0.002965539.5999YesNoYesYes90
1286x48 Lig histamine_off069.9402YesYesYesYes90
1293x37 4x57 histamine_off0.26934810.1897YesYesYesYes98
1304x57 Lig histamine_off017.4331YesYesYesYes80
1315x461 Lig histamine_off010.6261NoNoYesYes90
1323x37 3x41 histamine_off0.46375112.8813YesYesNoNo98
1333x40 Lig histamine_off025.4819NoNoYesYes90
1343x40 6x44 histamine_off0.14569825.352NoNoYesYes99
1353x44 5x54 histamine_off029.3011NoNoNoYes89
1363x43 5x54 histamine_off067.5812YesNoNoYes99
1373x44 3x48 histamine_off025.2169NoNoNoNo86
1383x48 5x57 histamine_off0.16951523.1904NoNoYesNo67
1393x51 5x57 histamine_off0.25399316.9966NoYesYesNo97
1403x51 5x61 histamine_off010.9119NoYesNoNo99
1413x52 I2x53 histamine_off015.4222NoNoYesYes89
1423x49 I2x53 histamine_off0.93175718.119NoNoYesYes99
1432x42 3x49 histamine_off0.50801738.701YesYesNoNo89
1443x52 I2x57 histamine_off015.4586NoNoNoYes89
1453x49 I2x57 histamine_off019.4024NoNoNoYes99
1465x47 5x48 histamine_off0.30901811.5614YesYesNoNo98
1475x54 6x41 histamine_off035.6664NoYesYesNo99
1485x58 6x41 histamine_off0.60693431.6082YesYesYesNo99
1498x47 8x50 histamine_off0.0012265711.1354YesNoYesNo99
1506x48 7x45 histamine_off0.01929964.7129YesYesNoYes99
1516x51 7x38 histamine_off3.3418213.3229YesYesYesYes98
1527x38 7x42 histamine_off0.011489436.3575YesYesYesYes89
1536x54 7x34 histamine_off012.9696NoNoNoYes77
1547x54 8x54 histamine_off012.7046NoNoYesYes99
155I2x52 I2x56 histamine_off1.2371715.5781NoYesNoNo58
1563x52 I2x52 histamine_off0.37323427.8618NoNoNoYes85
1575x65 6x31 histamine_off014.2738NoNoNoYes97
1585x65 6x34 histamine_off015.9314NoNoNoNo99
1593x50 6x34 histamine_off017.9683YesNoNoNo99
1603x50 6x37 histamine_off021.3614YesNoNoNo99
1617x54 8x51 histamine_off011.1198NoNoNoNo98
1621x39 7x39 histamine_off8.2262410.7976NoNoYesYes89
1633x32 7x42 histamine_off5.9593721.1691YesNoYesYes99
1647x45 7x49 histamine_off0.16251386.2562NoYesYesNo99
1657x38 Lig histamine_off4.9924725.4456YesYesYesYes80
1666x48 6x51 histamine_off022.7747YesYesYesYes99
1676x44 7x45 histamine_off022.8787YesYesNoYes99
1686x51 7x34 histamine_off3.3492910.5586YesYesNoYes97

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Midway



Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Node1Node2OwnerNet1LinkStrengthNet2LinkStrengthComm1Comm2Node1ShellNode2Shell
2x532x56Shared3.743332.5640122
2x563x32Shared7.38.90051121
2x567x42Shared6.732.8421121
2x577x39Shared5.042.62151122
2x577x42Shared6.783334.3621121
2x607x39Shared8.663334.28351122
2x607x42Shared3.876675.7041121
3x327x42Shared5.366679.41111
3x32LigShared11.57339.58051110
3x334x57Shared8.3611.7191111
3x33E2x52Shared4.576673.21951112
3x33LigShared15.912.0611110
3x366x48Shared4.123.84551111
3x36LigShared9.956.1321110
3x374x57Shared7.283.92751121
3x375x461Shared7.314.67751121
3x405x50histamine_off6.2066700112
3x406x44Shared7.953333.80750112
3x40Lighistamine_off4.5900110
4x575x43Shared7.683333.73951112
4x575x461Shared9.042.8051111
4x57Lighistamine_off4.6566701110
E2E2Shared52.2846.95351122
E2E2x52Shared17.44678.42751122
5x461Lighistamine_off8.9033301110
5x476x52Shared27.86679.8810121
6x446x48Shared6.013333.7581121
6x447x45histamine_off7.2466701122
6x486x51histamine_off7.3966701111
6x487x41Shared11.269.4061111
6x487x45Shared3.766678.1361112
6x48Lighistamine_off12.013301110
6x516x55Shared10.664.4931111
6x517x34Shared4.716673.07751112
6x517x37Shared6.243334.65451112
6x517x38Shared5.244.21951111
6x51LigShared11.2315.68551110
6x52LigShared16.84673.15250110
6x55Lighistamine_off6.3066701010
7x347x38histamine_off4.8601121
7x387x42Shared5.248.20151111
7x38LigShared4.9966710.13051110
7x397x42Shared8.683337.8961121
5x406x55Shared7.033336.5390121
5x465x49histamine_off2.8533300012
5x446x52Shared2.772.98450021
5x495x50Shared2.186673.37650022
5x425x46histamine_off0.48666700021
2x537x42histamine_on_gp03.01650121
2x607x38histamine_on_gp06.5681121
3x323x36histamine_on_gp02.66151111
3x33E2histamine_on_gp04.2281112
3x406x48histamine_on_gp07.2780111
5x40E2histamine_on_gp03.51150122
5x476x44histamine_on_gp03.85950122
5x476x48histamine_on_gp04.1110121
6x516x52histamine_on_gp02.581111
7x42Lighistamine_on_gp06.92151110
3x334x62histamine_on_gp02.77951112
4x564x57histamine_on_gp02.64450021
6x517x41histamine_on_gp04.08151111
7x41Lighistamine_on_gp05.20750110
5x46Lighistamine_on_gp03.2920010

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
Id Description
histamine_on_gp h1_on_gp
h2_on_gp
h3_on_gp
h4_on_gp
histamine_off h1_off
Network Difference
Value histamine_on_gp histamine_off
Imin 2.525 3.66667
Number of Linked Nodes 930 249
Number of Specific Nodes 682 (73.33%) 1  (0.40%)
Number of Shared Nodes 248 (26.67%) 248  (99.60%)
Number of Links 1128 271
Number of Specific Links 966 (85.64%) 109  (40.22%)
Number of Shared Links 162 (14.36%) 162  (59.78%)
Number of Hubs 182 28
Number of Specific Hubs 163 (89.56%) 9  (32.14%)
Number of Shared Hubs 19 (10.44%) 19  (67.86%)
Average % Shared Neighbours (Jaccard) 11.11
Average % Shared Neighbours (Otsuka) 13.97
Average % Shared Neighbours (Overlap Coefficient) 16.88
Average % Shared Cliques (k3-6) 51.31
Graphlets Similarity 0.687268
Paths Difference
Value histamine_on_gp histamine_off
Number Of Nodes in MetaPath 91 73
Specific Nodes in MetaPath 75 (82.42%) 57  (78.08%)
Shared Nodes in MetaPath 248 (26.67%) 248  (26.67%)
Number Of Links MetaPath 96 79
Specific Links in MetaPath 89 (92.71%) 72  (91.14%)
Shared Links in MetaPath 162 (14.36%) 162  (14.36%)
Number of Shortest Paths 7332992 45209
Length Of Smallest Path 3 3
Average Path Length 42.5342 13.1962
Length of Longest Path 68 28
Minimum Path Strength 0.34475 0.413333
Average Path Strength 4.65063 6.20244
Maximum Path Strength 21.057 22.3567
Minimum Path Correlation 0.7 0.7
Average Path Correlation 0.987984 0.911136
Maximum Path Correlation 1 0.99
Minimum % Of Corr. Nodes 1.63934 4
Average % Of Corr. Nodes 23.698 46.4475
Maximum % Of Corr. Nodes 100 100
Minimum Path Hubs % 0 0
Average Path Hubs % 64.0909 36.4397
Maximum Path Hubs % 100 100

Details about the values in these tables can be found in the corresponding documentation page .

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download histamine_off_on_gp.zip<



You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.



You can also  read or  download a guide explaining the meaning of all files and numerical data.