psnGPCR

Press and hold down the left mouse button and move the mouse to rotate.
Press and hold down the central mouse button and move the mouse to translate.
Use the mouse wheel to zoom in or out.
Click on any atom on your molecule and the corresponding residue label will be placed beneath the viewer.

Orange: nodes, hubs and links specific of kop_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of kop_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	kop_off Int. Strength	kop_on Int. Strength	kop_off Hub1?	kop_on Hub1?	kop_off Hub2?	kop_on Hub2?	ConSurf1	ConSurf2
1	NT.P56	NT.S55	kop_off	5.34	0	No	No	No	No	2	1
2	1x43	2x54	kop_off	3.89	0	Yes	Yes	No	No	7	6
3	1x52	8x54	kop_off	6.09	0	No	No	No	No	6	6
4	1x52	8x57	kop_off	4.87	0	No	No	No	No	6	4
5	1x53	7x53	kop_off	3.79	0	No	No	Yes	Yes	9	9
6	1x54	2x48	kop_off	4.24	0	Yes	No	No	No	7	6
7	1x55	1x59	kop_off	4.28	0	No	No	No	No	4	5
8	1x55	8x57	kop_off	7.5	0	No	No	No	No	4	4
9	1x56	8x53	kop_off	5.12	0	No	No	No	No	8	6
10	1x57	8x50	kop_off	3.77	0	No	No	Yes	Yes	7	8
11	1x58	2x44	kop_off	7.54	0	No	No	No	No	3	5
12	1x60	8x53	kop_off	4.03	0	No	Yes	No	No	5	6
13	2x40	I1x50	kop_off	5.61	0	No	No	No	No	7	7
14	8x50	I1x50	kop_off	7.46	0	Yes	Yes	No	No	8	7
15	2x38	3x49	kop_off	4.63	0	No	No	No	No	6	8
16	2x39	3x50	kop_off	6.47	0	No	No	Yes	No	8	9
17	2x39	6x33	kop_off	4.56	0	No	No	No	No	8	7
18	2x40	8x50	kop_off	7.25	0	No	No	Yes	Yes	7	8
19	2x41	4x42	kop_off	4.87	0	Yes	No	No	No	5	7
20	2x42	4x45	kop_off	7.25	0	Yes	Yes	No	No	7	6
21	2x43	7x53	kop_off	12.09	0	No	No	Yes	Yes	8	9
22	2x43	8x50	kop_off	3.77	0	No	No	Yes	Yes	8	8
23	2x45	3x38	kop_off	4.39	0	Yes	No	Yes	No	9	7
24	2x45	3x42	kop_off	8.77	0	Yes	No	No	No	9	7
25	2x45	4x49	kop_off	4.25	0	Yes	No	No	No	9	7
26	2x48	4x50	kop_off	4.56	0	No	No	Yes	No	6	9
27	2x53	3x35	kop_off	16.26	0	No	No	No	No	7	8
28	2x54	2x57	kop_off	6.02	0	No	No	Yes	Yes	6	7
29	2x56	3x31	kop_off	4.56	0	Yes	No	No	No	7	5
30	2x56	Lig	kop_off	5.74	0	Yes	No	Yes	Yes	7	0
31	2x58	2x59	kop_off	5.78	0	No	No	No	No	8	5
32	2x66	E1x51	kop_off	6.71	0	No	No	No	No	4	1
33	3x28	E1x50	kop_off	7.36	0	No	No	Yes	Yes	6	8
34	3x22	E2.G198	kop_off	5.03	0	No	No	No	No	2	4
35	3x33	4x56	kop_off	5.05	0	No	No	Yes	No	5	5
36	3x35	6x48	kop_off	4.52	0	No	No	Yes	Yes	8	8
37	3x36	6x52	kop_off	5.25	0	No	No	No	Yes	7	8
38	3x39	6x44	kop_off	3.96	0	No	No	Yes	No	9	9
39	3x40	3x41	kop_off	3.77	0	No	No	Yes	No	7	6
40	3x40	6x44	kop_off	7.54	0	No	No	Yes	No	7	9
41	3x42	4x49	kop_off	4.56	0	No	No	No	No	7	7
42	3x43	6x44	kop_off	6.09	0	No	No	Yes	No	8	9
43	3x44	5x54	kop_off	7.6	0	No	No	No	No	7	8
44	3x46	6x37	kop_off	6.09	0	No	No	No	No	8	8
45	3x50	3x53	kop_off	5.53	0	Yes	No	No	No	9	8
46	3x50	6x33	kop_off	8.77	0	Yes	No	No	No	9	7
47	3x50	6x34	kop_off	10.35	0	Yes	No	No	No	9	6
48	3x50	6x37	kop_off	6.54	0	Yes	No	No	No	9	8
49	3x51	5x64	kop_off	18.52	0	Yes	Yes	No	No	7	5
50	3x54	5x64	kop_off	6.54	0	No	No	No	No	8	5
51	I2x52	I2x55	kop_off	5.53	0	No	No	No	No	4	4
52	I2x52	I2x57	kop_off	11.14	0	No	No	No	No	4	6
53	I2x55	I2x57	kop_off	7.15	0	No	No	No	No	4	6
54	4x38	I2x55	kop_off	4.34	0	No	No	No	No	7	4
55	4x40	4x43	kop_off	4.23	0	No	No	No	No	4	4
56	E2.I208	E2.T199	kop_off	4.56	0	No	No	No	No	4	4
57	E2.R202	E2.V205	kop_off	3.92	0	No	Yes	No	No	2	1
58	E2.V205	E2.V207	kop_off	6.41	0	No	No	No	Yes	1	3
59	E2x50	Lig	kop_off	4.12	0	No	No	Yes	Yes	9	0
60	5x32	E2x51	kop_off	3.82	0	No	No	No	No	1	4
61	5x32	E2.F214	kop_off	12.38	0	No	No	Yes	Yes	1	6
62	5x39	E2.F214	kop_off	6.22	0	No	No	Yes	Yes	5	6
63	5x35	E2.P215	kop_off	5.4	0	Yes	No	No	No	7	5
64	E2.D216	E2.D217	kop_off	6.65	0	No	No	No	No	2	1
65	5x32	5x36	kop_off	12.64	0	No	No	No	No	1	4
66	5x35	5x38	kop_off	4.01	0	Yes	No	No	No	7	4
67	5x37	5x41	kop_off	4.28	0	No	No	No	No	3	5
68	5x40	6x58	kop_off	4.05	0	Yes	No	No	No	4	5
69	5x47	5x51	kop_off	5.24	0	Yes	No	No	No	8	6
70	5x58	6x38	kop_off	17.58	0	Yes	Yes	No	No	8	4
71	I3.L258	I3.R257	kop_off	6.07	0	No	No	No	No	5	4
72	6x24	I3.S260	kop_off	3.95	0	No	No	No	No	3	4
73	6x26	6x27	kop_off	9.68	0	No	No	No	No	4	3
74	6x27	6x30	kop_off	5.43	0	No	No	No	Yes	3	6
75	6x29	8x48	kop_off	5.26	0	No	No	Yes	No	5	4
76	6x36	8x47	kop_off	4.07	0	No	No	No	No	8	8
77	6x39	7x56	kop_off	4.47	0	No	No	No	No	5	7
78	6x44	7x45	kop_off	7.25	0	Yes	No	Yes	No	9	9
79	6x48	7x41	kop_off	4.22	0	Yes	Yes	No	No	8	7
80	6x48	Lig	kop_off	5.91	0	Yes	Yes	Yes	Yes	8	0
81	6x50	7x37	kop_off	3.77	0	No	No	No	No	9	7
82	6x51	7x38	kop_off	4.42	0	No	Yes	Yes	Yes	6	5
83	6x54	7x37	kop_off	4.19	0	No	No	No	No	5	7
84	6x56	6x60	kop_off	4.15	0	No	No	No	No	5	4
85	8x48	8x49	kop_off	6.57	0	Yes	No	No	No	4	6
86	8x50	8x54	kop_off	9.65	0	Yes	Yes	No	No	8	6
87	2x63	E1x50	kop_off	3.68	0	No	No	Yes	Yes	5	8
88	E2.F214	E2x52	kop_off	3.65	0	Yes	Yes	No	No	6	4
89	1x46	2x54	kop_off	3.64	0	No	No	No	No	8	6
90	3x51	5x61	kop_off	3.59	0	Yes	Yes	No	No	7	8
91	7x32	7x33	kop_off	3.26	0	No	No	No	No	2	4
92	1x44	1x48	kop_off	3.21	0	No	No	No	No	5	4
93	7x43	7x47	kop_off	3.2	0	No	No	No	Yes	5	7
94	1x45	7x51	kop_off	3.07	0	No	No	No	No	5	7
95	2x66	E1x49	kop_off	3.07	0	No	No	No	No	4	4
96	5x51	5x55	kop_off	3.07	0	No	No	No	No	6	5
97	5x54	6x41	kop_off	3.07	0	No	No	No	No	8	8
98	3x23	3x24	kop_off	2.98	0	No	No	No	No	1	5
99	6x40	7x49	kop_off	2.96	0	No	No	Yes	Yes	8	9
100	7x43	7x48	kop_off	2.95	0	No	No	No	No	5	6
101	1x31	1x35	kop_off	2.94	0	No	No	No	No	4	5
102	5x45	5x49	kop_off	2.94	0	No	No	No	No	5	5
103	4x41	I2x52	kop_off	2.87	0	No	No	No	No	5	4
104	3x21	E1x50	kop_off	2.81	0	No	No	Yes	Yes	7	8
105	8x57	8x58	kop_off	2.79	0	No	No	No	No	4	5
106	8x58	8x59	kop_off	2.79	0	No	No	No	No	5	4
107	7x54	8x54	kop_off	2.77	0	No	No	No	No	7	6
108	3x30	3x34	kop_off	2.54	0	No	No	Yes	Yes	5	5
109	5x66	I3.R257	kop_off	2.48	0	No	No	No	No	4	4
110	3x50	6x30	kop_off	2.43	0	Yes	No	No	Yes	9	6
111	2x64	2x65	kop_off	2.34	0	No	Yes	No	No	4	4
112	E2.E203	E2.R202	kop_off	2.33	0	No	No	No	Yes	1	2
113	4x57	4x60	kop_off	1.95	0	No	No	No	No	6	5
114	1x48	1x49	kop_off	1.84	0	No	No	No	No	4	7
115	1x30	NT.S55	kop_off	1.71	0	No	No	No	No	4	1
116	7x40	7x41	kop_off	1.71	0	No	No	No	No	8	7
117	2x41	4x39	kop_off	1.69	0	Yes	No	No	No	5	2
118	1x30	1x34	kop_off	1.62	0	No	No	No	No	4	5
119	4x56	4x59	kop_off	1.62	0	Yes	No	No	No	5	7
120	1x54	2x51	kop_off	1.61	0	Yes	No	No	No	7	8
121	6x27	I2x50	kop_off	1.61	0	No	No	No	No	3	8
122	1x38	1x42	kop_off	1.6	0	No	No	No	No	5	7
123	5x51	6x45	kop_off	1.6	0	No	No	No	No	6	6
124	5x37	6x59	kop_off	1.58	0	No	No	No	No	3	4
125	2x55	2x56	kop_off	1.57	0	No	No	Yes	No	4	7
126	1x31	NT.S55	kop_off	1.55	0	No	No	No	No	4	1
127	1x34	1x38	kop_off	1.54	0	No	No	No	No	5	5
128	4x58	4x62	kop_off	1.54	0	No	No	No	No	4	4
129	1x51	1x54	kop_off	1.53	0	No	No	Yes	No	4	7
130	I1x48	I1x51	kop_off	1.5	0	No	No	No	No	6	7
131	5x67	I3.L259	kop_off	1.5	0	No	No	No	No	4	3
132	1x57	I1x51	kop_off	1.45	0	No	No	No	No	7	7
133	2x41	I1x51	kop_off	1.45	0	Yes	No	No	No	5	7
134	8x59	CT.P347	kop_off	1.44	0	No	No	No	No	4	4
135	2x52	3x31	kop_off	1.43	0	No	No	No	No	6	5
136	5x62	5x63	kop_off	1.43	0	No	No	No	No	5	4
137	5x60	5x63	kop_off	1.38	0	No	No	No	No	4	4
138	I3.L258	I3.L259	kop_off	1.38	0	No	No	No	No	5	3
139	E2.D204	E2.E203	kop_off	1.3	0	No	No	No	No	2	1
140	1x39	1x40	kop_off	1.27	0	No	Yes	No	No	6	4
141	6x26	6x28	kop_off	1.24	0	No	No	No	No	4	4
142	7x55	8x51	kop_off	1.24	0	No	No	No	No	6	8
143	3x51	3x52	kop_off	1.21	0	Yes	Yes	No	No	7	5
144	8x52	8x56	kop_off	1.19	0	No	No	No	No	5	3
145	8x55	8x56	kop_off	1.19	0	No	No	No	No	5	3
146	6x25	6x28	kop_off	1.16	0	No	No	No	No	3	4
147	5x31	5x34	kop_off	1.12	0	No	No	No	No	4	1
148	1x31	1x32	Shared	6.77	2.25667	No	No	No	No	4	4
149	1x39	2x57	Shared	5.99	3.19333	No	Yes	Yes	Yes	6	7
150	1x39	2x61	Shared	8.9	1.69667	No	Yes	No	No	6	6
151	1x42	2x57	Shared	4.56	2.53667	No	No	Yes	Yes	7	7
152	1x42	7x47	Shared	8.08	4.84667	No	No	No	Yes	7	7
153	1x43	2x57	Shared	4.98	9.12333	Yes	Yes	Yes	Yes	7	7
154	1x43	2x58	Shared	4.33	3.37	Yes	Yes	No	No	7	8
155	1x49	7x50	Shared	4.06	2.03	No	No	No	No	7	9
156	1x50	2x47	Shared	4.69	2.08333	No	Yes	No	No	9	8
157	1x50	2x50	Shared	5.39	6.73	No	Yes	No	Yes	9	9
158	1x50	7x50	Shared	11.4	8.14667	No	Yes	No	No	9	9
159	1x54	2x44	Shared	4.98	4.56333	Yes	No	No	No	7	5
160	1x59	1x60	Shared	4.12	3.77333	No	No	No	Yes	5	5
161	2x37	2x40	Shared	5.85	6.82333	No	No	No	No	7	7
162	2x41	4x46	Shared	4.25	2.83333	Yes	No	No	No	5	7
163	2x42	3x46	Shared	5.99	5.59	Yes	Yes	No	No	7	8
164	2x42	3x49	Shared	8.05	6.13333	Yes	Yes	No	No	7	8
165	2x42	4x42	Shared	6.67	3.11	Yes	Yes	No	No	7	7
166	2x42	4x46	Shared	4.65	7.36333	Yes	Yes	No	No	7	7
167	2x45	4x46	Shared	20.43	12.7133	Yes	No	No	No	9	7
168	2x45	4x50	Shared	10.17	5.65	Yes	No	Yes	No	9	9
169	2x46	3x43	Shared	6.92	4.15333	No	Yes	No	No	9	8
170	2x46	7x53	Shared	4.69	3.91	No	Yes	Yes	Yes	9	9
171	2x50	7x46	Shared	8.83	4.90667	No	Yes	No	No	9	8
172	2x50	7x49	Shared	6.73	9.87333	No	Yes	Yes	Yes	9	9
173	2x56	7x42	Shared	4.99	3.74667	Yes	No	Yes	Yes	7	6
174	2x57	7x42	Shared	17.96	11.5733	Yes	Yes	Yes	Yes	7	6
175	2x59	E1x52	Shared	16.08	3.21333	No	No	Yes	Yes	5	7
176	2x60	7x38	Shared	5.49	4.57	No	No	Yes	Yes	7	5
177	2x60	7x42	Shared	5.64	11.2733	No	No	Yes	Yes	7	6
178	2x60	Lig	Shared	9.5	14.5433	No	No	Yes	Yes	7	0
179	2x62	E1x52	Shared	3.89	3.03	No	No	Yes	Yes	4	7
180	2x64	7x35	Shared	10.92	14.5633	No	Yes	No	Yes	4	4
181	2x67	E2.V207	Shared	4.43	1.47667	No	No	No	Yes	5	3
182	E1x50	E1x52	Shared	15.03	16.37	Yes	Yes	Yes	Yes	8	7
183	3x25	E1x50	Shared	5.22	6.09333	No	No	Yes	Yes	9	8
184	E1x50	E2x50	Shared	23.51	12.6233	Yes	Yes	No	No	8	9
185	E1x51	E1x52	Shared	13	6.26	No	No	Yes	Yes	1	7
186	3x24	E1x52	Shared	7.31	4.05667	No	No	Yes	Yes	5	7
187	3x22	E2.T199	Shared	5.78	8.67	No	No	No	No	2	4
188	3x25	E2x50	Shared	7.28	7.28	No	No	No	No	9	9
189	3x28	Lig	Shared	3.87	4.68	No	No	Yes	Yes	6	0
190	3x30	4x61	Shared	6.19	6.19	No	No	No	No	5	4
191	3x32	Lig	Shared	33.47	17.1433	No	No	Yes	Yes	6	0
192	3x33	Lig	Shared	6.09	8.37	No	No	Yes	Yes	5	0
193	3x34	4x50	Shared	8.68	9.64667	Yes	Yes	Yes	No	5	9
194	3x34	4x54	Shared	7.63	1.69333	Yes	Yes	No	No	5	4
195	3x34	4x57	Shared	10.14	1.45	Yes	Yes	No	No	5	6
196	3x36	6x48	Shared	6.98	5.04333	No	No	Yes	Yes	7	8
197	3x36	Lig	Shared	11.01	8.09333	No	No	Yes	Yes	7	0
198	3x37	3x41	Shared	4.29	3.57	No	Yes	Yes	No	6	6
199	3x37	4x56	Shared	9.18	9.61667	No	Yes	Yes	No	6	5
200	3x37	5x461	Shared	8.32	3.69667	No	Yes	No	No	6	6
201	3x38	4x50	Shared	15.77	12.9333	Yes	No	Yes	No	7	9
202	3x38	4x53	Shared	4.8	4.26667	Yes	No	No	No	7	8
203	3x40	5x50	Shared	6.77	3.39	No	No	No	No	7	9
204	3x41	4x49	Shared	7.54	5.86333	Yes	No	No	No	6	7
205	3x45	4x45	Shared	5.83	3.40333	No	Yes	No	No	6	6
206	3x47	5x54	Shared	7.74	5.67333	No	No	No	No	9	8
207	3x47	5x58	Shared	10.17	8.05667	No	No	Yes	Yes	9	8
208	3x51	5x57	Shared	4.03	7.61667	Yes	Yes	No	No	7	7
209	3x51	5x60	Shared	7.03	7.03	Yes	Yes	No	No	7	4
210	3x54	5x65	Shared	4.47	4.47	No	No	No	No	8	8
211	3x55	5x64	Shared	8.36	2.79	No	No	No	No	7	5
212	4x38	4x39	Shared	5.25	4.08333	No	No	No	No	7	2
213	4x47	4x51	Shared	4.28	1.90333	No	No	No	No	4	4
214	4x63	E2.F214	Shared	4.87	5.27667	No	No	Yes	Yes	4	6
215	E2.G198	E2.Q213	Shared	6.58	2.19	No	No	No	No	4	4
216	E2.E209	E2.K200	Shared	12.15	2.7	No	No	No	No	3	2
217	E2.E209	E2.R202	Shared	16.28	5.04	No	No	No	Yes	3	2
218	5x35	E2.F214	Shared	7.02	1.66667	Yes	No	Yes	Yes	7	6
219	5x34	5x35	Shared	17.81	9.99667	No	No	Yes	No	1	7
220	5x34	5x38	Shared	15.03	3.34333	No	No	No	No	1	4
221	5x36	5x40	Shared	16.59	6.45	No	No	Yes	No	4	4
222	5x38	5x42	Shared	4.19	6.52	No	No	No	No	4	3
223	5x40	6x55	Shared	7.27	6.78333	Yes	No	No	No	4	5
224	5x43	Lig	Shared	8.7	4.28333	No	No	Yes	Yes	5	0
225	5x44	5x48	Shared	5.24	3.49333	No	Yes	No	No	5	4
226	5x44	6x56	Shared	15.83	6.49333	No	Yes	No	No	5	5
227	5x45	5x46	Shared	6.28	3.76667	No	No	No	No	5	4
228	5x47	6x49	Shared	6.49	5.62333	Yes	No	No	Yes	8	5
229	5x47	6x52	Shared	15.84	6.03333	Yes	No	No	Yes	8	8
230	5x49	5x50	Shared	5.08	3.39	No	No	No	No	5	9
231	5x58	6x37	Shared	3.79	7.99	Yes	Yes	No	No	8	8
232	6x32	6x35	Shared	18.13	1.42	No	Yes	No	No	7	6
233	6x36	7x56	Shared	4.15	2.76667	No	No	No	No	8	7
234	6x44	6x48	Shared	22.05	6.34667	Yes	No	Yes	Yes	9	8
235	6x47	7x45	Shared	7.87	6.29667	No	No	Yes	No	8	9
236	6x48	6x51	Shared	4.7	3.91667	Yes	Yes	No	Yes	8	6
237	6x48	6x52	Shared	4.23	4.93667	Yes	Yes	No	Yes	8	8
238	6x48	7x45	Shared	6.78	9.04	Yes	Yes	Yes	No	8	9
239	6x51	6x55	Shared	4.42	3.92667	No	Yes	No	No	6	5
240	6x54	7x34	Shared	7.22	8.59667	No	No	No	Yes	5	4
241	6x55	Lig	Shared	10.19	6.10333	No	No	Yes	Yes	5	0
242	7x31	7x35	Shared	8.21	3.12667	No	No	No	Yes	4	4
243	7x34	7x35	Shared	6.95	4.63333	No	Yes	No	Yes	4	4
244	7x34	7x38	Shared	13.3	7.65333	No	Yes	Yes	Yes	4	5
245	7x36	7x40	Shared	6.09	3.65333	No	No	No	No	5	8
246	7x38	Lig	Shared	4.63	4.68333	Yes	Yes	Yes	Yes	5	0
247	7x42	Lig	Shared	13.7	6.50667	Yes	Yes	Yes	Yes	6	0
248	7x45	7x49	Shared	9.54	4.99333	Yes	No	Yes	Yes	9	9
249	7x49	7x53	Shared	8.14	3.87333	Yes	Yes	Yes	Yes	9	9
250	8x47	8x49	Shared	8.08	2.69333	No	No	No	No	8	6
251	8x47	8x50	Shared	11.94	3.18333	No	No	Yes	Yes	8	8
252	8x48	8x52	Shared	8.14	1.94	Yes	No	No	No	4	5
253	1x43	1x47	Shared	3.65	4.46667	Yes	Yes	No	No	7	6
254	5x58	5x61	Shared	3.59	2.79333	Yes	Yes	No	No	8	8
255	6x32	8x48	Shared	3.49	9.69	No	Yes	Yes	No	7	4
256	2x49	3x38	Shared	3.36	2.8	No	No	Yes	No	8	7
257	1x45	7x47	Shared	3.23	1.61667	No	No	No	Yes	5	7
258	E1x49	E2.I208	Shared	3.1	2.58	No	No	No	No	4	4
259	4x54	4x58	Shared	3.1	1.03333	No	No	No	No	4	4
260	3x44	5x53	Shared	3.04	4.05333	No	No	No	No	7	6
261	3x45	3x48	Shared	3.04	2.53333	No	Yes	No	No	6	6
262	6x40	7x52	Shared	2.98	2.98	No	No	No	No	8	8
263	6x43	7x52	Shared	2.98	3.97333	No	No	No	No	7	8
264	3x55	3x56	Shared	2.95	3.44	No	No	No	Yes	7	6
265	3x27	3x31	Shared	2.94	1.47	No	No	No	No	5	5
266	2x41	4x43	Shared	2.91	2.42333	Yes	No	No	No	5	4
267	3x22	3x26	Shared	2.77	6.45333	No	No	No	No	2	6
268	3x29	Lig	Shared	2.7	7.17667	No	No	Yes	Yes	4	0
269	6x54	7x33	Shared	2.64	5.28333	No	No	No	No	5	4
270	7x51	7x55	Shared	2.51	2.09333	No	No	No	No	7	6
271	5x44	5x47	Shared	2.14	7.86	No	Yes	Yes	No	5	8
272	4x64	E2.G198	Shared	2.11	2.11	No	No	No	No	4	4
273	4x44	4x48	Shared	1.64	0.546667	No	No	No	No	3	4
274	E1x49	E2.V207	Shared	1.62	2.15333	No	No	No	Yes	4	3
275	4x55	4x56	Shared	1.62	2.15333	No	No	Yes	No	4	5
276	5x40	6x59	Shared	1.61	2.67667	Yes	No	No	No	4	4
277	1x41	1x45	Shared	1.6	0.533333	No	No	No	No	5	5
278	E2.I208	E2.V201	Shared	1.54	2.56	No	No	No	No	4	2
279	5x55	5x59	Shared	1.52	1.01333	No	No	No	No	5	4
280	6x49	6x53	Shared	1.52	2.53333	No	Yes	No	No	5	5
281	5x48	5x52	Shared	1.49	1.49	No	No	No	No	4	3
282	5x56	5x60	Shared	1.49	1.98667	No	No	No	No	4	4
283	3x41	4x52	Shared	1.22	1.22	Yes	No	No	No	6	4
284	1x36	2x65	kop_on	0	4.42333	No	No	No	No	5	4
285	1x39	7x35	kop_on	0	6.95	No	Yes	No	Yes	6	4
286	1x39	7x39	kop_on	0	5.78333	No	Yes	No	No	6	5
287	1x42	7x43	kop_on	0	7.40333	No	No	No	No	7	5
288	1x43	1x44	kop_on	0	3.05667	Yes	Yes	No	No	7	5
289	1x50	2x51	kop_on	0	4.69	No	Yes	No	No	9	8
290	1x53	2x47	kop_on	0	4.52333	No	No	No	No	9	8
291	1x56	1x60	kop_on	0	4.62333	No	No	No	Yes	8	5
292	1x56	8x50	kop_on	0	11.7967	No	No	Yes	Yes	8	8
293	1x57	2x44	kop_on	0	5.44333	No	No	No	No	7	5
294	2x40	I1x48	kop_on	0	4.87333	No	No	No	No	7	6
295	I1x49	I1x51	kop_on	0	4.31	No	No	No	No	5	7
296	2x41	I1x50	kop_on	0	3.4	Yes	No	No	No	5	7
297	2x38	2x42	kop_on	0	3.11333	No	No	Yes	Yes	6	7
298	2x42	3x45	kop_on	0	5.19	Yes	Yes	No	Yes	7	6
299	2x44	2x45	kop_on	0	3.22	No	No	Yes	No	5	9
300	2x46	2x50	kop_on	0	5.88333	No	Yes	No	Yes	9	9
301	2x46	3x42	kop_on	0	4.91333	No	Yes	No	No	9	7
302	2x48	2x52	kop_on	0	3.23	No	No	No	No	6	6
303	2x50	3x39	kop_on	0	5.4	No	Yes	No	No	9	9
304	2x52	3x35	kop_on	0	13.2733	No	No	No	No	6	8
305	2x53	7x46	kop_on	0	4.30667	No	No	No	No	7	8
306	2x56	3x28	kop_on	0	3.17333	Yes	No	No	No	7	6
307	2x56	3x32	kop_on	0	7.22667	Yes	No	No	No	7	6
308	2x59	E1x50	kop_on	0	3.00667	No	No	Yes	Yes	5	8
309	2x59	3x28	kop_on	0	8.3	No	No	No	No	5	6
310	2x62	2x66	kop_on	0	3.01	No	No	No	No	4	4
311	2x63	7x35	kop_on	0	3.36667	No	No	No	Yes	5	4
312	3x25	E2.T199	kop_on	0	3.94333	No	No	No	No	9	4
313	3x26	E2.G198	kop_on	0	4.06667	No	No	No	No	6	4
314	3x29	3x33	kop_on	0	3.15	No	No	No	No	4	5
315	3x30	4x60	kop_on	0	3.42	No	No	No	No	5	5
316	3x31	3x35	kop_on	0	3.30333	No	No	No	No	5	8
317	3x32	7x42	kop_on	0	3.45	No	No	Yes	Yes	6	6
318	3x33	E2x52	kop_on	0	3.91	No	No	No	No	5	4
319	3x34	3x35	kop_on	0	5.42667	Yes	Yes	No	No	5	8
320	3x36	3x37	kop_on	0	3.73333	No	No	No	Yes	7	6
321	3x37	5x43	kop_on	0	5.24	No	Yes	No	No	6	5
322	3x43	7x53	kop_on	0	5.47	No	No	Yes	Yes	8	9
323	3x44	5x50	kop_on	0	3.5	No	No	No	No	7	9
324	3x45	4x49	kop_on	0	3.88667	No	Yes	No	No	6	7
325	3x46	7x53	kop_on	0	6.38667	No	No	Yes	Yes	8	9
326	3x49	I2x57	kop_on	0	13.5	No	No	No	No	8	6
327	3x50	5x58	kop_on	0	8.57333	Yes	No	Yes	Yes	9	8
328	3x50	7x53	kop_on	0	6.51667	Yes	No	Yes	Yes	9	9
329	3x51	3x55	kop_on	0	8.06333	Yes	Yes	No	No	7	7
330	3x51	3x56	kop_on	0	7.26	Yes	Yes	No	Yes	7	6
331	3x52	I2x56	kop_on	0	7.11667	No	No	No	No	5	4
332	3x53	I2x57	kop_on	0	5.07	No	No	No	No	8	6
333	3x54	5x61	kop_on	0	6.59667	No	No	No	No	8	8
334	4x38	4x41	kop_on	0	5.00333	No	No	No	No	7	5
335	E2.K200	E2.Q213	kop_on	0	14.9167	No	No	No	No	2	4
336	E2.D204	E2.R202	kop_on	0	5.16	No	No	No	Yes	2	2
337	5x36	E2.F214	kop_on	0	9.15333	No	No	Yes	Yes	4	6
338	5x31	E2.D217	kop_on	0	3.54667	No	No	No	No	4	1
339	5x32	Lig	kop_on	0	8.23	No	No	Yes	Yes	1	0
340	5x44	6x52	kop_on	0	8.67333	No	Yes	No	Yes	5	8
341	5x45	5x48	kop_on	0	3.07333	No	No	No	No	5	4
342	5x51	6x44	kop_on	0	3.49333	No	No	Yes	No	6	9
343	5x62	6x34	kop_on	0	5.57333	No	No	No	No	5	6
344	5x65	I3.L259	kop_on	0	4.61333	No	No	No	No	8	3
345	5x68	I3.L259	kop_on	0	2.98	No	No	No	No	6	3
346	6x30	I3.L259	kop_on	0	5.07333	No	Yes	No	No	6	3
347	6x29	6x32	kop_on	0	5.22667	No	No	No	Yes	5	7
348	6x40	7x53	kop_on	0	5.47	No	No	Yes	Yes	8	9
349	6x45	6x49	kop_on	0	3.17333	No	No	No	Yes	6	5
350	6x49	6x50	kop_on	0	3.5	No	Yes	No	No	5	9
351	6x51	7x37	kop_on	0	3.27333	No	Yes	No	No	6	7
352	6x54	6x58	kop_on	0	6.22	No	No	No	No	5	5
353	6x58	Lig	kop_on	0	3.49	No	No	Yes	Yes	5	0
354	7x34	Lig	kop_on	0	11.4867	No	Yes	Yes	Yes	4	0
355	7x35	7x38	kop_on	0	4.83667	No	Yes	Yes	Yes	4	5
356	7x54	8x50	kop_on	0	3.69667	No	No	Yes	Yes	7	8
357	8x48	8x51	kop_on	0	4.95	Yes	No	No	No	4	8
358	1x31	1x33	kop_on	0	3.58333	No	No	No	No	4	5
359	1x33	2x64	kop_on	0	3.78667	No	No	No	Yes	5	4
360	1x36	2x64	kop_on	0	4.16	No	No	No	Yes	5	4
361	1x47	2x54	kop_on	0	3.44	No	No	No	No	6	6
362	2x46	7x49	kop_on	0	6.41	No	Yes	Yes	Yes	9	9
363	3x43	7x49	kop_on	0	4.57667	No	No	Yes	Yes	8	9
364	E2.R202	E2.V207	kop_on	0	4.36	No	Yes	No	Yes	2	3
365	E2.E209	E2.V207	kop_on	0	3.32667	No	No	No	Yes	3	3
366	6x23	6x24	kop_on	0	4.83333	No	No	No	No	0	3
367	6x25	6x29	kop_on	0	3.50333	No	No	No	No	3	5
368	6x52	Lig	kop_on	0	3.22333	No	Yes	Yes	Yes	8	0
369	8x50	I1x48	kop_on	0	3.89	Yes	Yes	No	No	8	6
370	E2.R202	E3.H304	kop_on	0	3.38667	No	Yes	No	No	2	0
371	4x41	I2x56	kop_on	0	2.89333	No	No	No	No	5	4
372	1x35	2x64	kop_on	0	2.82	No	No	No	Yes	5	4
373	5x66	6x30	kop_on	0	2.82	No	No	No	Yes	4	6
374	E2.D216	E2.K200	kop_on	0	2.76667	No	No	No	No	2	2
375	3x40	6x48	kop_on	0	2.74	No	No	Yes	Yes	7	8
376	5x64	5x67	kop_on	0	2.63667	No	No	No	No	5	4
377	3x56	I2x52	kop_on	0	2.62	No	Yes	No	No	6	4
378	2x37	2x39	kop_on	0	2.61667	No	No	No	No	7	8
379	3x48	3x52	kop_on	0	2.56	No	No	No	No	6	5
380	5x55	6x41	kop_on	0	2.56	No	No	No	No	5	8
381	2x39	2x43	kop_on	0	2.53333	No	No	No	No	8	8
382	5x58	6x41	kop_on	0	2.52	Yes	Yes	No	No	8	8
383	1x46	7x47	kop_on	0	2.47333	No	No	No	Yes	8	7
384	E2.D206	E2.V207	kop_on	0	2.43333	No	No	No	Yes	3	3
385	1x60	8x51	kop_on	0	2.39	No	Yes	No	No	5	8
386	7x48	7x51	kop_on	0	2.38	No	No	No	No	6	7
387	5x65	6x33	kop_on	0	2.37667	No	No	No	No	8	7
388	3x47	5x57	kop_on	0	2.29333	No	No	No	No	9	7
389	6x60	6x61	kop_on	0	2.28	No	No	No	No	4	2
390	5x34	5x37	kop_on	0	2.27667	No	No	No	No	1	3
391	1x53	7x54	kop_on	0	2.26	No	No	No	No	9	7
392	8x53	I1x48	kop_on	0	2.25333	No	No	No	No	6	6
393	6x31	6x35	kop_on	0	2.13333	No	No	No	No	5	6
394	1x55	1x60	kop_on	0	2.06333	No	No	No	Yes	4	5
395	5x39	5x43	kop_on	0	2.02667	No	No	No	No	5	5
396	6x32	6x36	kop_on	0	2.02333	No	Yes	No	No	7	8
397	7x47	7x48	kop_on	0	2.00333	No	Yes	No	No	7	6
398	4x62	4x63	kop_on	0	1.98667	No	No	No	No	4	4
399	6x30	6x34	kop_on	0	1.96333	No	Yes	No	No	6	6
400	6x34	6x38	kop_on	0	1.96333	No	No	No	No	6	4
401	E2.Q213	E2x51	kop_on	0	1.92333	No	No	No	No	4	4
402	4x40	4x44	kop_on	0	1.90333	No	No	No	No	4	3
403	6x26	I3.L258	kop_on	0	1.88	No	No	No	No	4	5
404	3x30	4x57	kop_on	0	1.86	No	No	No	No	5	6
405	I2x53	I2x57	kop_on	0	1.84667	No	No	No	No	5	6
406	6x26	I3.G261	kop_on	0	1.74333	No	No	No	No	4	3
407	1x52	7x55	kop_on	0	1.62333	No	No	No	No	6	6
408	1x52	1x55	kop_on	0	1.62333	No	No	No	No	6	4
409	6x57	E3.S301	kop_on	0	1.61667	No	No	No	No	4	2
410	1x31	7x32	kop_on	0	1.54667	No	No	No	No	4	2
411	3x56	I2x50	kop_on	0	1.53	No	Yes	No	No	6	8
412	1x51	1x52	kop_on	0	1.5	No	No	No	No	4	6
413	6x30	I3.S260	kop_on	0	1.5	No	Yes	No	No	6	4
414	6x39	7x52	kop_on	0	1.49	No	No	No	No	5	8
415	7x40	7x43	kop_on	0	1.47333	No	No	No	No	8	5
416	5x33	E2.D216	kop_on	0	1.47333	No	No	No	No	2	2
417	5x41	5x45	kop_on	0	1.47	No	No	No	No	5	5
418	6x27	I3.S260	kop_on	0	1.47	No	No	No	No	3	4
419	E2.D204	E2.V205	kop_on	0	1.46	No	No	No	No	2	1
420	1x57	I1x49	kop_on	0	1.45333	No	No	No	No	7	5
421	1x58	I1x49	kop_on	0	1.45333	No	No	No	No	3	5
422	5x37	6x60	kop_on	0	1.38333	No	No	No	No	3	4
423	6x23	I3.G261	kop_on	0	1.23667	No	No	No	No	0	3
424	6x51	7x41	kop_on	0	1.17667	No	Yes	No	No	6	7
425	1x38	7x39	kop_on	0	1.13333	No	No	No	No	5	5
426	7x28	7x29	kop_on	0	1.12	No	No	No	No	0	4
427	1x48	1x51	kop_on	0	1.07667	No	No	No	No	4	4
428	E2.D217	E2.P215	kop_on	0	1.07333	No	No	No	No	1	5
429	8x52	8x55	kop_on	0	1.06667	No	No	No	No	5	5
430	6x28	6x35	kop_on	0	1.06667	No	No	No	No	4	6
431	6x53	6x57	kop_on	0	1.02667	No	No	No	No	5	4
432	3x21	E1x52	kop_on	0	1.00667	No	No	Yes	Yes	7	7
433	4x51	4x54	kop_on	0	1	No	No	No	No	4	4
434	5x68	I3.L258	kop_on	0	0.993333	No	No	No	No	6	5
435	2x52	2x55	kop_on	0	0.983333	No	No	No	No	6	4
436	4x38	4x40	kop_on	0	0.98	No	No	No	No	7	4
437	5x59	5x63	kop_on	0	0.98	No	No	No	No	4	4
438	E2.F214	E2.P215	kop_on	0	0.96	Yes	Yes	No	No	6	5
439	I2x54	I2x55	kop_on	0	0.906667	No	No	No	No	5	4
440	I2x50	I2x51	kop_on	0	0.59	No	No	No	No	8	5
441	7x27	7x30	kop_on	0	0.57	No	No	No	No	0	3
442	7x30	7x33	kop_on	0	0.57	No	No	No	No	3	4
443	6x46	6x47	kop_on	0	0.57	No	No	No	No	6	8
444	7x27	7x29	kop_on	0	0.57	No	No	No	No	0	4
445	7x29	7x32	kop_on	0	0.57	No	No	No	No	4	2
446	7x30	E3.T302	kop_on	0	0.56	No	No	No	No	3	0
447	7x27	E3.S303	kop_on	0	0.543333	No	No	No	No	0	0
448	1x36	1x40	kop_on	0	0.533333	No	No	No	No	5	4
449	3x23	3x27	kop_on	0	0.513333	No	No	No	No	1	5
450	4x59	5x39	kop_on	0	0.51	No	No	No	No	7	5

Orange: nodes, hubs and links specific of kop_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of kop_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	kop_off Avg Int. Strength	kop_on Avg Int. Strength	kop_off Num Of Links	kop_on Num Of Links	ConSurf
1	1x54	kop_off	3.09	4.56333	4	1	7
2	2x41	kop_off	3.034	2.88556	5	3	5
3	2x45	kop_off	9.602	7.19444	5	3	9
4	2x56	kop_off	4.215	4.71556	4	3	7
5	3x38	kop_off	7.08	6.66667	4	3	7
6	3x41	kop_off	4.205	3.55111	4	3	6
7	3x50	kop_off	6.68167	7.545	6	2	9
8	4x50	kop_off	9.795	9.41	4	3	9
9	4x56	kop_off	4.3675	5.885	4	2	5
10	5x35	kop_off	8.56	5.83167	4	2	7
11	5x40	kop_off	7.38	5.30333	4	3	4
12	5x47	kop_off	7.4275	6.50556	4	3	8
13	6x44	kop_off	9.378	4.92	5	2	9
14	7x45	kop_off	7.86	6.77667	4	3	9
15	8x48	kop_off	5.865	5.52667	4	3	4
16	1x43	Shared	4.2125	5.00417	4	4	7
17	2x42	Shared	6.522	5.08333	5	6	7
18	2x57	Shared	7.902	6.60667	5	4	7
19	E1x50	Shared	9.60167	9.52333	6	4	8
20	E1x52	Shared	11.062	5.65611	5	6	7
21	3x34	Shared	7.2475	4.55417	4	4	5
22	3x51	Shared	6.876	7.4925	5	4	7
23	E2.F214	Shared	6.828	4.26417	5	4	6
24	5x58	Shared	8.7825	5.98667	4	5	8
25	6x48	Shared	7.42375	5.33722	8	6	8
26	7x38	Shared	6.96	5.43583	4	4	5
27	7x42	Shared	10.5725	7.31	4	5	6
28	7x49	Shared	6.8425	5.94533	4	5	9
29	7x53	Shared	7.1775	5.27111	4	6	9
30	8x50	Shared	7.30667	5.64167	6	4	8
31	Lig	Shared	9.20231	7.71524	13	14	0
32	1x39	kop_on	5.38667	4.40583	3	4	6
33	1x50	kop_on	7.16	5.4125	3	4	9
34	1x60	kop_on	4.075	3.2125	2	4	5
35	2x46	kop_on	5.805	5.054	2	5	9
36	2x50	kop_on	6.98333	6.55867	3	5	9
37	2x64	kop_on	6.63	6.3325	2	4	4
38	3x37	kop_on	7.26333	5.17133	3	5	6
39	3x45	kop_on	4.435	3.75333	2	4	6
40	3x56	kop_on	2.95	3.7125	1	4	6
41	E2.R202	kop_on	7.51	4.48667	3	4	2
42	E2.V207	kop_on	4.15333	2.75	3	5	3
43	5x44	kop_on	7.73667	6.63	3	4	5
44	6x30	kop_on	3.93	2.83917	2	4	6
45	6x32	kop_on	10.81	4.59	2	4	7
46	6x49	kop_on	4.005	3.7075	2	4	5
47	6x51	kop_on	4.51333	3.07333	3	4	6
48	6x52	kop_on	8.44	5.71667	3	4	8
49	7x34	kop_on	9.15667	8.0925	3	4	4
50	7x35	kop_on	8.69333	6.24611	3	6	4
51	7x47	kop_on	4.83667	2.735	3	4	7

Orange: nodes, hubs and links specific of kop_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of kop_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	kop_off Recurrence	kop_on Recurrence	kop_off Hub1?	kop_on Hub1?	kop_off Hub2?	kop_on Hub2?	ConSurf1	ConSurf2
1	1x38	1x42	kop_off	11.8219	0	No	No	No	No	5	7
2	1x34	1x38	kop_off	10.3731	0	No	No	No	No	5	5
3	6x48	Lig	kop_off	79.6917	0	Yes	Yes	Yes	Yes	8	0
4	1x52	8x54	kop_off	14.9469	0	No	No	No	No	6	6
5	8x50	8x54	kop_off	17.8361	0	Yes	Yes	No	No	8	6
6	2x43	8x50	kop_off	34.7161	0	No	No	Yes	Yes	8	8
7	2x43	7x53	kop_off	35.0699	0	No	No	Yes	Yes	8	9
8	1x52	8x57	kop_off	13.4897	0	No	No	No	No	6	4
9	2x48	4x50	kop_off	10.9628	0	No	No	Yes	No	6	9
10	2x45	4x49	kop_off	97.6078	0	Yes	No	No	No	9	7
11	3x37	4x56	kop_off	41.2315	4.17909	No	Yes	Yes	No	6	5
12	3x33	4x56	kop_off	42.7729	0	No	No	Yes	No	5	5
13	3x33	Lig	kop_off	43.2488	3.8483	No	No	Yes	Yes	5	0
14	3x40	3x41	kop_off	62.8327	0	No	No	Yes	No	7	6
15	3x40	6x44	kop_off	66.5179	0	No	No	Yes	No	7	9
16	6x44	6x48	kop_off	61.1734	4.02069	Yes	No	Yes	Yes	9	8
17	1x57	8x50	kop_off	22.6541	0	No	No	Yes	Yes	7	8
18	3x50	6x37	kop_off	22.5615	0	Yes	No	No	No	9	8
19	3x46	6x37	kop_off	63.2202	0	No	No	No	No	8	8
20	2x41	4x46	kop_off	27.2785	6.88595	Yes	No	No	No	5	7
21	2x41	4x42	kop_off	10.8406	0	Yes	No	No	No	5	7
22	2x42	4x42	kop_off	10.7564	2.30153	Yes	Yes	No	No	7	7
23	7x34	7x38	kop_off	23.2311	0.0605665	No	Yes	Yes	Yes	4	5
24	2x66	E1x51	kop_off	46.5423	0	No	No	No	No	4	1
25	E1x51	E1x52	kop_off	49.0482	2.25028	No	No	Yes	Yes	1	7
26	E1x49	E2.V207	kop_off	21.02	6.7322	No	No	No	Yes	4	3
27	2x66	E1x49	kop_off	44.028	0	No	No	No	No	4	4
28	3x28	E1x50	kop_off	32.9009	0	No	No	Yes	Yes	6	8
29	E1x50	E2x50	kop_off	32.9894	2.14778	Yes	Yes	No	No	8	9
30	E2x50	Lig	kop_off	35.4195	0	No	No	Yes	Yes	9	0
31	E2.I208	E2.T199	kop_off	15.8145	0	No	No	No	No	4	4
32	E1x49	E2.I208	kop_off	21.02	4.4959	No	No	No	No	4	4
33	5x58	6x37	kop_off	40.625	1.70518	Yes	Yes	No	No	8	8
34	3x51	5x61	kop_off	24.861	0	Yes	Yes	No	No	7	8
35	3x51	5x64	kop_off	10.5037	0	Yes	Yes	No	No	7	5
36	2x41	4x39	kop_off	11.8977	0	Yes	No	No	No	5	2
37	5x32	E2.F214	kop_off	21.8918	0	No	No	Yes	Yes	1	6
38	5x32	5x36	kop_off	26.0487	0	No	No	No	No	1	4
39	E2.R202	E2.V205	kop_off	13.1991	0	No	Yes	No	No	2	1
40	E2.V205	E2.V207	kop_off	15.8145	0	No	No	No	Yes	1	3
41	6x27	6x30	kop_off	10.3689	0	No	No	No	Yes	3	6
42	3x50	6x30	kop_off	12.2978	0	Yes	No	No	Yes	9	6
43	8x48	8x49	kop_off	10.3479	0	Yes	No	No	No	4	6
44	8x47	8x49	kop_off	11.8219	2.32482	No	No	No	No	8	6
45	8x47	8x50	kop_off	17.6255	4.64499	No	No	Yes	Yes	8	8
46	1x57	I1x51	kop_off	22.1782	0	No	No	No	No	7	7
47	E1x50	E1x52	kop_off	58.5622	0.642937	Yes	Yes	Yes	Yes	8	7
48	2x41	I1x51	kop_off	21.3191	0	Yes	No	No	No	5	7
49	1x42	2x57	Shared	24.482	36.68	No	No	Yes	Yes	7	7
50	1x42	7x47	Shared	11.8219	29.7288	No	No	No	Yes	7	7
51	2x50	7x49	Shared	12.9001	44.6049	No	Yes	Yes	Yes	9	9
52	7x45	7x49	Shared	40.3344	97.7637	Yes	No	Yes	Yes	9	9
53	6x48	7x45	Shared	36.0091	100	Yes	Yes	Yes	No	8	9
54	7x42	Lig	Shared	33.0231	45.2525	Yes	Yes	Yes	Yes	6	0
55	2x57	7x42	Shared	33.7727	48.9051	Yes	Yes	Yes	Yes	7	6
56	7x49	7x53	Shared	33.8149	82.4031	Yes	Yes	Yes	Yes	9	9
57	2x45	4x50	Shared	26.6552	44.3487	Yes	No	Yes	No	9	9
58	3x41	4x49	Shared	100	67.3733	Yes	No	No	No	6	7
59	3x37	3x41	Shared	41.6189	70.2525	No	Yes	Yes	No	6	6
60	2x42	4x46	Shared	67.9372	67.1543	Yes	Yes	No	No	7	7
61	2x45	4x46	Shared	77.9523	58.9918	Yes	No	No	No	9	7
62	2x42	3x46	Shared	65.0691	37.5699	Yes	Yes	No	No	7	8
63	7x38	Lig	Shared	16.7242	26.435	Yes	Yes	Yes	Yes	5	0
64	3x28	Lig	Shared	34.017	60.3569	No	No	Yes	Yes	6	0
65	3x22	E2.T199	Shared	13.1991	42.0239	No	No	No	No	2	4
66	3x34	4x50	Shared	14.551	35.7762	Yes	Yes	Yes	No	5	9
67	6x48	6x52	Shared	16.421	51.8776	Yes	Yes	No	Yes	8	8
68	3x47	5x58	Shared	10.5037	27.227	No	No	Yes	Yes	9	8
69	5x58	5x61	Shared	26.8784	36.9922	Yes	Yes	No	No	8	8
70	5x36	5x40	Shared	28.1755	24.3431	No	No	Yes	No	4	4
71	5x40	6x55	Shared	38.6877	27.8327	Yes	No	No	No	4	5
72	6x55	Lig	Shared	28.1418	21.6316	No	No	Yes	Yes	5	0
73	5x35	E2.F214	Shared	13.237	12.8354	Yes	No	Yes	Yes	7	6
74	5x47	6x52	Shared	21.8287	11.2467	Yes	No	No	Yes	8	8
75	6x48	6x51	Shared	19.9587	11.5123	Yes	Yes	No	Yes	8	6
76	6x51	6x55	Shared	13.3465	11.1349	No	Yes	No	No	6	5
77	6x54	7x34	Shared	11.6745	14.7363	No	No	No	Yes	5	4
78	1x36	2x64	kop_on	0	10.4454	No	No	No	Yes	5	4
79	2x64	7x35	kop_on	4.69592	30.9215	No	Yes	No	Yes	4	4
80	1x39	7x35	kop_on	0	16.4648	No	Yes	No	Yes	6	4
81	1x39	2x57	kop_on	4.49377	11.8291	No	Yes	Yes	Yes	6	7
82	1x39	7x39	kop_on	0	10.1985	No	Yes	No	No	6	5
83	1x43	2x57	kop_on	6.22894	10.4081	Yes	Yes	Yes	Yes	7	7
84	7x34	7x35	kop_on	9.40448	26.1694	No	Yes	No	Yes	4	4
85	7x34	Lig	kop_on	0	39.6618	No	Yes	Yes	Yes	4	0
86	3x36	Lig	kop_on	7.59771	77.828	No	No	Yes	Yes	7	0
87	3x36	6x48	kop_on	0.576988	46.7667	No	No	Yes	Yes	7	8
88	1x50	2x50	kop_on	9.72456	53.7831	No	Yes	No	Yes	9	9
89	7x35	7x38	kop_on	0	25.1537	No	Yes	Yes	Yes	4	5
90	6x52	Lig	kop_on	0	54.2443	No	Yes	Yes	Yes	8	0
91	1x50	2x47	kop_on	1.63831	45.3783	No	Yes	No	No	9	8
92	1x53	2x47	kop_on	0	43.2818	No	No	No	No	9	8
93	3x36	3x37	kop_on	0	41.3949	No	No	No	Yes	7	6
94	3x45	4x49	kop_on	0	66.4974	No	Yes	No	No	6	7
95	2x42	3x45	kop_on	0	57.7525	Yes	Yes	No	Yes	7	6
96	2x44	2x45	kop_on	0	13.6927	No	No	Yes	No	5	9
97	5x43	Lig	kop_on	1.46563	40.0298	No	No	Yes	Yes	5	0
98	3x37	5x43	kop_on	0	37.7889	No	Yes	No	No	6	5
99	7x47	7x48	kop_on	0	22.6845	No	Yes	No	No	7	6
100	7x48	7x51	kop_on	0	20.9281	No	No	No	No	6	7
101	7x51	7x55	kop_on	3.00286	19.2182	No	No	No	No	7	6
102	1x52	7x55	kop_on	0	17.9883	No	No	No	No	6	6
103	1x52	1x55	kop_on	0	17.6947	No	No	No	No	6	4
104	1x55	1x60	kop_on	0	17.8485	No	No	No	Yes	4	5
105	1x56	1x60	kop_on	0	22.5261	No	No	No	Yes	8	5
106	1x56	8x50	kop_on	0	23.579	No	No	Yes	Yes	8	8
107	1x53	7x54	kop_on	0	41.2318	No	No	No	No	9	7
108	7x54	8x50	kop_on	0	39.2564	No	No	Yes	Yes	7	8
109	8x50	I1x48	kop_on	0	13.3433	Yes	Yes	No	No	8	6
110	3x34	3x35	kop_on	0	15.943	Yes	Yes	No	No	5	8
111	2x59	3x28	kop_on	0	63.539	No	No	No	No	5	6
112	2x59	E1x52	kop_on	4.96547	12.4394	No	No	Yes	Yes	5	7
113	2x59	E1x50	kop_on	0	49.3245	No	No	Yes	Yes	5	8
114	3x25	E1x50	kop_on	0.126348	46.0399	No	No	Yes	Yes	9	8
115	3x25	E2.T199	kop_on	0	44.0924	No	No	No	No	9	4
116	3x22	3x26	kop_on	2.6533	39.946	No	No	No	No	2	6
117	3x26	E2.G198	kop_on	0	37.8587	No	No	No	No	6	4
118	3x50	7x53	kop_on	0	73.7933	Yes	No	Yes	Yes	9	9
119	3x50	5x58	kop_on	0	72.377	Yes	No	Yes	Yes	9	8
120	3x47	5x57	kop_on	0	23.0712	No	No	No	No	9	7
121	3x51	5x57	kop_on	2.11422	20.9793	Yes	Yes	No	No	7	7
122	3x45	3x48	kop_on	2.11422	20.4715	No	Yes	No	No	6	6
123	3x48	3x52	kop_on	0	18.1793	No	No	No	No	6	5
124	3x52	I2x56	kop_on	0	15.8777	No	No	No	No	5	4
125	3x54	5x61	kop_on	0	34.9609	No	No	No	No	8	8
126	3x54	5x65	kop_on	2.11422	32.9296	No	No	No	No	8	8
127	4x41	I2x56	kop_on	0	13.5669	No	No	No	No	5	4
128	4x38	4x41	kop_on	0	11.7359	No	No	No	No	7	5
129	5x36	E2.F214	kop_on	0	22.5773	No	No	Yes	Yes	4	6
130	E2.G198	E2.Q213	kop_on	2.6533	33.6564	No	No	No	No	4	4
131	E2.K200	E2.Q213	kop_on	0	29.4167	No	No	No	No	2	4
132	E2.E209	E2.K200	kop_on	2.6533	23.4765	No	No	No	No	3	2
133	5x34	5x35	kop_on	4.42638	11.0417	No	No	Yes	No	1	7
134	5x44	6x52	kop_on	0	11.2467	No	Yes	No	Yes	5	8
135	5x65	I3.L259	kop_on	0	29.2956	No	No	No	No	8	3
136	6x30	I3.L259	kop_on	0	14.6524	No	Yes	No	No	6	3
137	5x68	I3.L259	kop_on	0	12.9659	No	No	No	No	6	3
138	1x60	8x51	kop_on	0	23.402	No	Yes	No	No	5	8
139	8x48	8x51	kop_on	0	21.4219	Yes	No	No	No	4	8
140	6x32	8x48	kop_on	2.94811	16.0641	No	Yes	Yes	No	7	4
141	6x54	6x58	kop_on	0	13.4551	No	No	No	No	5	5
142	6x54	7x33	kop_on	4.72962	24.3897	No	No	No	No	5	4
143	1x31	1x33	kop_on	0	11.2747	No	No	No	No	4	5
144	1x33	2x64	kop_on	0	14.3915	No	No	No	Yes	5	4
145	E2.E209	E2.V207	kop_on	0	13.2734	No	No	No	Yes	3	3
146	5x68	I3.L258	kop_on	0	10.8274	No	No	No	No	6	5
147	7x30	7x33	kop_on	0	20.7603	No	No	No	No	3	4
148	3x46	7x53	kop_on	0	38.7766	No	No	Yes	Yes	8	9
149	6x58	Lig	kop_on	0	15.0624	No	No	Yes	Yes	5	0
150	7x27	7x30	kop_on	0	13.5063	No	No	No	No	0	3
151	2x46	2x50	kop_on	0	17.4851	No	Yes	No	Yes	9	9
152	2x46	7x53	kop_on	2.4722	17.8205	No	Yes	Yes	Yes	9	9

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
2x56	3x31	kop_off	4.56	0	1	1	1	2
2x56	7x42	Shared	4.99	3.74667	1	1	1	1
2x56	Lig	kop_off	5.74	0	1	1	1	0
2x57	7x42	Shared	17.96	11.5733	1	0	2	1
2x60	7x38	Shared	5.49	4.57	1	1	1	1
2x60	7x42	Shared	5.64	11.2733	1	1	1	1
2x60	Lig	Shared	9.5	14.5433	1	1	1	0
3x25	E1x50	Shared	5.22	6.09333	1	3	2	2
3x28	E1x50	kop_off	7.36	0	0	0	1	2
E1x50	E2x50	Shared	23.51	12.6233	1	3	2	1
3x25	E2x50	Shared	7.28	7.28	1	3	2	1
3x28	Lig	Shared	3.87	4.68	0	0	1	0
3x32	Lig	Shared	33.47	17.1433	0	1	1	0
3x33	4x56	kop_off	5.05	0	0	1	1	2
3x33	Lig	Shared	6.09	8.37	0	1	1	0
3x35	6x48	kop_off	4.52	0	0	0	2	1
3x36	6x48	Shared	6.98	5.04333	1	0	1	1
3x36	6x52	kop_off	5.25	0	1	0	1	1
3x36	Lig	Shared	11.01	8.09333	1	0	1	0
3x37	4x56	Shared	9.18	9.61667	0	0	2	2
3x40	6x44	kop_off	7.54	0	0	0	2	2
E2x50	Lig	kop_off	4.12	0	1	3	1	0
5x32	E2x51	kop_off	3.82	0	0	0	1	2
5x32	E2.F214	kop_off	12.38	0	0	0	1	2
5x39	E2.F214	kop_off	6.22	0	0	0	2	2
5x32	5x36	kop_off	12.64	0	0	0	1	2
5x36	5x40	Shared	16.59	6.45	0	0	2	2
5x40	6x55	Shared	7.27	6.78333	0	0	2	1
5x40	6x58	kop_off	4.05	0	0	0	2	1
5x43	Lig	Shared	8.7	4.28333	0	0	1	0
5x47	6x52	Shared	15.84	6.03333	0	1	2	1
6x44	6x48	Shared	22.05	6.34667	1	0	2	1
6x44	7x45	kop_off	7.25	0	1	0	2	2
6x48	6x51	Shared	4.7	3.91667	1	0	1	2
6x48	6x52	Shared	4.23	4.93667	1	0	1	1
6x48	7x41	kop_off	4.22	0	1	0	1	2
6x48	7x45	Shared	6.78	9.04	1	0	1	2
6x48	Lig	kop_off	5.91	0	1	0	1	0
6x51	6x55	Shared	4.42	3.92667	0	0	2	1
6x51	7x38	kop_off	4.42	0	0	0	2	1
6x54	7x34	Shared	7.22	8.59667	0	0	2	1
6x55	Lig	Shared	10.19	6.10333	0	0	1	0
7x34	7x35	Shared	6.95	4.63333	0	1	1	2
7x34	7x38	Shared	13.3	7.65333	0	1	1	1
7x38	Lig	Shared	4.63	4.68333	1	1	1	0
7x42	Lig	Shared	13.7	6.50667	1	1	1	0
E2.F214	E2x52	kop_off	3.65	0	0	0	2	2
3x29	Lig	Shared	2.7	7.17667	0	1	1	0
5x44	5x47	Shared	2.14	7.86	0	1	2	2
2x55	2x56	kop_off	1.57	0	0	0	2	1
2x56	3x28	kop_on	0	3.17333	1	1	1	1
2x56	3x32	kop_on	0	7.22667	1	1	1	1
2x59	E1x50	kop_on	0	3.00667	0	3	2	2
2x59	3x28	kop_on	0	8.3	0	3	2	1
3x29	3x33	kop_on	0	3.15	0	1	1	1
3x31	3x35	kop_on	0	3.30333	0	0	2	2
3x32	7x42	kop_on	0	3.45	0	1	1	1
3x33	E2x52	kop_on	0	3.91	0	1	1	2
3x36	3x37	kop_on	0	3.73333	1	0	1	2
3x37	5x43	kop_on	0	5.24	0	0	2	1
5x36	E2.F214	kop_on	0	9.15333	0	0	2	2
5x32	Lig	kop_on	0	8.23	0	0	1	0
5x44	6x52	kop_on	0	8.67333	0	1	2	1
6x54	6x58	kop_on	0	6.22	0	0	2	1
6x58	Lig	kop_on	0	3.49	0	0	1	0
7x34	Lig	kop_on	0	11.4867	0	1	1	0
7x35	7x38	kop_on	0	4.83667	0	1	2	1
6x52	Lig	kop_on	0	3.22333	1	1	1	0
3x40	6x48	kop_on	0	2.74	0	0	2	1
5x39	5x43	kop_on	0	2.02667	0	0	2	1
6x51	7x41	kop_on	0	1.17667	0	0	2	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	kop_off	4DJH-κ-JDTic
	kop_on	8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2

Network Difference
Value	kop_off	kop_on
I_min	3.77	2.89667
Number of Linked Nodes	267	280
Number of Specific Nodes	12 (4.49%)	25 (8.93%)
Number of Shared Nodes	255 (95.51%)	255 (91.07%)
Number of Links	283	303
Number of Specific Links	147 (51.94%)	167 (55.12%)
Number of Shared Links	136 (48.06%)	136 (44.88%)
Number of Hubs	31	36
Number of Specific Hubs	15 (48.39%)	20 (55.56%)
Number of Shared Hubs	16 (51.61%)	16 (44.44%)
Average % Shared Neighbours (Jaccard)	30.88
Average % Shared Neighbours (Otsuka)	39.19
Average % Shared Neighbours (Overlap Coefficient)	47.37
Average % Shared Cliques (k3-6)	52.68
Graphlets Similarity	0.547695

Paths Difference
Value	kop_off	kop_on
Number Of Nodes in MetaPath	73	96
Specific Nodes in MetaPath	28 (38.36%)	51 (53.13%)
Shared Nodes in MetaPath	255 (95.51%)	255 (95.51%)
Number Of Links MetaPath	77	104
Specific Links in MetaPath	48 (62.34%)	75 (72.12%)
Shared Links in MetaPath	136 (48.06%)	136 (48.06%)
Number of Shortest Paths	56638	67072
Length Of Smallest Path	3	3
Average Path Length	13.5668	13.9794
Length of Longest Path	28	33
Minimum Path Strength	1.19	0.561111
Average Path Strength	7.49257	5.43735
Maximum Path Strength	23.585	15.8433
Minimum Path Correlation	0.7	0.7
Average Path Correlation	0.927016	0.919438
Maximum Path Correlation	0.99	0.99
Minimum % Of Corr. Nodes	4.16667	3.57143
Average % Of Corr. Nodes	51.1576	42.4198
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	42.6738	40.5104
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download kop_off_on.zip<

You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.

You can also read or download a guide explaining the meaning of all files and numerical data.