psnGPCR

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Orange: nodes, hubs and links specific of leuko_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of leuko_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	leuko_off Int. Strength	leuko_on Int. Strength	leuko_off Hub1?	leuko_on Hub1?	leuko_off Hub2?	leuko_on Hub2?	ConSurf1	ConSurf2
1	1x27	1x30	leuko_off	3.84833	0	No	No	No	No	3	3
2	1x39	2x60	leuko_off	5.24	0	Yes	No	Yes	No	7	6
3	1x43	1x47	leuko_off	3.96667	0	Yes	No	No	No	6	5
4	1x43	2x58	leuko_off	8.00167	0	Yes	No	No	No	6	9
5	1x53	7x53	leuko_off	5.71	0	No	No	Yes	Yes	8	9
6	I1x48	I4	leuko_off	3.8	0	No	No	Yes	No	6	5
7	I1x50	I4	leuko_off	5.31	0	No	No	Yes	No	6	5
8	2x37	2x39	leuko_off	3.71	0	Yes	No	Yes	No	7	7
9	2x37	2x40	leuko_off	3.78	0	Yes	No	No	No	7	7
10	2x37	I4	leuko_off	5.165	0	Yes	No	Yes	No	7	5
11	2x39	I4	leuko_off	6.065	0	Yes	No	Yes	No	7	5
12	2x41	4x43	leuko_off	11.6167	0	No	No	No	No	6	4
13	2x42	3x45	leuko_off	4.08167	0	Yes	No	No	No	7	6
14	2x42	4x46	leuko_off	3.51	0	Yes	No	No	No	7	7
15	2x43	7x53	leuko_off	6.315	0	No	Yes	Yes	Yes	7	9
16	2x44	2x48	leuko_off	4.69167	0	Yes	No	No	No	6	5
17	2x45	3x42	leuko_off	4.59667	0	No	No	Yes	No	9	7
18	2x49	3x35	leuko_off	3.835	0	No	No	No	No	8	8
19	2x53	3x32	leuko_off	4.34833	0	No	No	Yes	No	6	6
20	2x54	7x46	leuko_off	4.63	0	No	No	No	No	5	9
21	2x60	3x28	leuko_off	3.54167	0	Yes	No	Yes	No	6	5
22	2x60	3x32	leuko_off	3.62	0	Yes	No	Yes	No	6	6
23	3x28	E1x50	leuko_off	4.86833	0	Yes	No	Yes	Yes	5	8
24	E1x50	E2	leuko_off	4.84	0	Yes	Yes	Yes	Yes	8	3
25	3x29	Lig	leuko_off	12.1267	0	No	Yes	Yes	Yes	6	0
26	3x30	4x54	leuko_off	6.205	0	Yes	No	No	No	5	3
27	3x30	4x59	leuko_off	3.705	0	Yes	No	No	No	5	4
28	3x32	Lig	leuko_off	3.74	0	Yes	No	Yes	Yes	6	0
29	3x36	6x51	leuko_off	4.19	0	No	No	Yes	Yes	7	6
30	3x37	5x461	leuko_off	3.625	0	Yes	Yes	No	No	7	5
31	3x44	5x54	leuko_off	4.345	0	Yes	No	No	No	7	8
32	3x50	6x37	leuko_off	4.77167	0	Yes	No	No	No	9	7
33	3x51	3x55	leuko_off	6.74	0	No	No	No	No	8	7
34	3x51	5x60	leuko_off	10.6667	0	No	No	Yes	No	8	3
35	4x65	Lig	leuko_off	6.085	0	No	No	Yes	Yes	5	0
36	E2x52	Lig	leuko_off	4.20833	0	Yes	No	Yes	Yes	4	0
37	5x36	6x58	leuko_off	4.65	0	Yes	No	Yes	Yes	4	3
38	5x58	6x38	leuko_off	7.35833	0	Yes	Yes	No	No	8	5
39	6x36	I4	leuko_off	4.345	0	No	No	Yes	No	7	5
40	6x40	7x49	leuko_off	3.54	0	No	No	Yes	No	7	9
41	6x47	6x48	leuko_off	3.52667	0	Yes	No	Yes	Yes	7	9
42	6x47	7x43	leuko_off	3.655	0	Yes	No	No	No	7	5
43	6x52	6x55	leuko_off	4.77833	0	Yes	Yes	Yes	No	8	6
44	6x55	7x34	leuko_off	6.83333	0	Yes	No	No	No	6	4
45	6x61	7x30	leuko_off	3.77	0	No	No	No	No	2	5
46	7x27	E3	leuko_off	5.325	0	No	No	Yes	Yes	3	4
47	7x61	I4	leuko_off	4.975	0	No	No	Yes	No	7	5
48	7x62	I4	leuko_off	13.68	0	No	Yes	Yes	No	6	5
49	I4	I4	leuko_off	34.035	0	Yes	No	Yes	No	5	5
50	1x25	E3	leuko_off	3.64	0	No	No	Yes	Yes	0	4
51	1x27	7x31	leuko_off	8.61667	0	No	No	No	No	3	3
52	1x28	1x31	leuko_off	6.525	0	No	No	No	No	3	2
53	1x30	1x34	leuko_off	6.43	0	No	No	No	No	3	5
54	1x30	7x32	leuko_off	7.03167	0	No	No	No	No	3	2
55	1x31	1x35	leuko_off	4.13667	0	No	No	Yes	No	2	5
56	1x32	E1	leuko_off	5.27	0	No	No	No	No	4	0
57	1x34	1x38	leuko_off	4.59	0	No	No	No	No	5	5
58	1x35	1x39	leuko_off	7.735	0	Yes	No	Yes	No	5	7
59	1x35	7x35	leuko_off	4.15333	0	Yes	No	No	No	5	4
60	1x36	2x65	leuko_off	3.83167	0	No	No	No	No	5	4
61	1x43	1x44	leuko_off	4.825	0	Yes	No	No	No	6	5
62	1x56	8x50	leuko_off	4.15167	0	No	No	No	No	7	0
63	1x57	7x53	leuko_off	4.98667	0	Yes	Yes	Yes	Yes	7	9
64	8x49	I1	leuko_off	8.85	0	No	No	No	No	0	0
65	8x52	I1	leuko_off	4.98	0	No	No	No	No	0	0
66	8x53	I1	leuko_off	4.23167	0	No	No	No	No	0	0
67	2x39	3x50	leuko_off	3.48833	0	Yes	No	Yes	No	7	9
68	2x46	2x50	leuko_off	4.34833	0	Yes	Yes	Yes	Yes	9	9
69	2x60	E2x51	leuko_off	7.89667	0	Yes	No	No	No	6	3
70	2x63	2x64	leuko_off	4.8	0	No	No	No	Yes	5	3
71	2x63	E1	leuko_off	4.45	0	No	No	No	No	5	0
72	2x66	E1x51	leuko_off	6.265	0	No	No	No	No	3	4
73	3x37	6x52	leuko_off	3.62833	0	Yes	Yes	Yes	Yes	7	8
74	3x40	6x48	leuko_off	6.90833	0	No	No	Yes	Yes	8	9
75	3x42	4x50	leuko_off	3.84333	0	Yes	No	Yes	No	7	9
76	3x50	6x33	leuko_off	3.50667	0	Yes	No	Yes	No	9	7
77	3x55	3x56	leuko_off	3.69	0	No	No	No	No	7	7
78	6x62	E2	leuko_off	3.79667	0	No	No	Yes	Yes	3	3
79	E2	Lig	leuko_off	4.50333	0	Yes	Yes	Yes	Yes	3	0
80	5x36	Lig	leuko_off	5.66167	0	Yes	No	Yes	Yes	4	0
81	5x40	6x56	leuko_off	3.655	0	No	No	No	No	4	5
82	5x51	6x49	leuko_off	5.48	0	Yes	Yes	No	No	6	6
83	5x58	5x62	leuko_off	4.23167	0	Yes	Yes	No	No	8	5
84	5x65	6x31	leuko_off	4.5	0	No	No	Yes	No	8	5
85	6x55	Lig	leuko_off	8.91167	0	Yes	No	Yes	Yes	6	0
86	7x28	E3	leuko_off	3.63	0	No	No	Yes	Yes	4	4
87	7x45	7x49	leuko_off	6.13	0	No	No	Yes	No	9	9
88	7x54	7x55	leuko_off	5.16	0	No	No	No	Yes	6	7
89	7x54	8x51	leuko_off	4.57833	0	No	No	No	No	6	0
90	6x33	8x49	leuko_off	4.19667	0	Yes	No	No	No	7	0
91	8x50	8x51	leuko_off	3.515	0	No	No	No	No	0	0
92	5x32	5x35	leuko_off	3.485	0	No	No	No	No	4	2
93	5x58	6x41	leuko_off	3.46	0	Yes	Yes	No	No	8	8
94	3x54	5x61	leuko_off	3.44167	0	No	No	No	No	8	8
95	1x54	2x44	leuko_off	3.42333	0	No	No	Yes	No	7	6
96	6x36	6x40	leuko_off	3.40667	0	No	No	No	No	7	7
97	1x49	7x50	leuko_off	3.38333	0	No	No	No	No	7	9
98	1x26	7x28	leuko_off	3.37167	0	No	No	No	No	0	4
99	2x41	4x42	leuko_off	3.335	0	No	No	No	No	6	7
100	1x39	2x57	leuko_off	3.33333	0	Yes	No	No	No	7	7
101	6x35	6x38	leuko_off	3.33	0	No	No	No	No	6	5
102	6x51	7x37	leuko_off	3.25167	0	Yes	Yes	No	No	6	7
103	4x43	I1x51	leuko_off	3.2	0	No	No	No	No	4	6
104	6x43	7x48	leuko_off	3.175	0	No	No	No	No	6	6
105	2x56	3x28	leuko_off	3.105	0	No	No	Yes	No	6	5
106	5x44	5x48	leuko_off	3.09667	0	No	No	No	No	5	4
107	8x56	8x59	leuko_off	3.075	0	No	No	No	No	0	0
108	2x37	8x48	leuko_off	3.05833	0	Yes	No	No	No	7	0
109	5x51	6x46	leuko_off	3.03667	0	Yes	Yes	No	No	6	5
110	1x51	2x51	leuko_off	3.005	0	No	No	No	No	3	7
111	3x52	I2x52	leuko_off	2.98	0	No	No	No	No	5	5
112	3x43	6x41	leuko_off	2.94667	0	No	No	No	No	8	8
113	6x58	6x61	leuko_off	2.91	0	Yes	Yes	No	No	3	2
114	1x60	I4	leuko_off	2.855	0	No	No	Yes	No	5	5
115	1x43	2x54	leuko_off	2.78333	0	Yes	No	No	No	6	5
116	3x33	4x61	leuko_off	2.735	0	No	No	No	No	4	4
117	5x38	5x42	leuko_off	2.68	0	No	No	No	No	3	3
118	3x48	5x57	leuko_off	2.64	0	No	No	No	No	6	6
119	5x68	6x31	leuko_off	2.53667	0	No	No	Yes	No	5	5
120	5x33	5x37	leuko_off	2.515	0	No	No	No	No	3	3
121	5x52	5x56	leuko_off	2.51333	0	No	No	No	No	3	4
122	6x34	I4	leuko_off	2.465	0	No	No	Yes	No	6	5
123	6x47	7x40	leuko_off	2.435	0	Yes	No	No	No	7	8
124	2x42	4x45	leuko_off	2.435	0	Yes	No	No	No	7	5
125	3x24	E1x50	leuko_off	2.43333	0	No	No	Yes	Yes	5	8
126	6x54	7x33	leuko_off	2.425	0	No	No	No	No	4	5
127	3x23	3x27	leuko_off	2.37833	0	No	No	No	No	1	4
128	1x40	2x61	leuko_off	2.365	0	No	No	No	No	5	7
129	3x30	4x61	leuko_off	2.285	0	Yes	No	No	No	5	4
130	3x41	4x52	leuko_off	2.28	0	No	No	No	No	5	4
131	6x29	6x33	leuko_off	2.275	0	No	No	Yes	No	0	7
132	5x61	6x38	leuko_off	2.20833	0	No	No	No	No	8	5
133	3x54	6x31	leuko_off	2.19	0	No	No	Yes	No	8	5
134	5x58	6x42	leuko_off	2.15	0	Yes	Yes	No	No	8	5
135	1x57	8x50	leuko_off	2.14333	0	Yes	Yes	No	No	7	0
136	1x58	1x59	leuko_off	2.115	0	No	No	Yes	No	3	4
137	6x30	6x31	leuko_off	2.09167	0	No	No	Yes	No	6	5
138	1x52	1x55	leuko_off	2.005	0	No	No	No	No	6	3
139	1x32	2x67	leuko_off	1.75	0	No	No	No	No	4	4
140	1x28	NT	leuko_off	1.745	0	No	No	No	No	3	0
141	4x40	I2x56	leuko_off	1.74333	0	No	No	No	No	5	4
142	3x53	I2x53	leuko_off	1.71	0	No	No	No	No	7	5
143	6x60	6x63	leuko_off	1.71	0	No	No	No	No	3	2
144	8x55	8x59	leuko_off	1.65167	0	No	No	No	No	0	0
145	6x32	6x33	leuko_off	1.65	0	No	No	Yes	No	7	7
146	4x40	4x44	leuko_off	1.59333	0	No	No	No	No	5	3
147	1x59	8x57	leuko_off	1.51667	0	Yes	No	No	No	4	0
148	7x58	7x62	leuko_off	1.5	0	No	Yes	No	Yes	4	6
149	7x26	7x30	leuko_off	1.49	0	No	No	No	No	2	5
150	1x56	8x54	leuko_off	1.49	0	No	No	No	No	7	0
151	5x41	6x56	leuko_off	1.425	0	No	No	No	No	4	5
152	2x48	2x52	leuko_off	1.425	0	No	No	No	No	5	6
153	5x56	5x60	leuko_off	1.425	0	No	No	Yes	No	4	3
154	5x62	5x66	leuko_off	1.425	0	No	No	No	No	5	5
155	1x47	2x55	leuko_off	1.385	0	No	No	No	No	5	5
156	4x55	4x56	leuko_off	1.385	0	No	No	No	No	4	4
157	5x67	I3	leuko_off	1.385	0	No	No	Yes	Yes	4	4
158	6x461	7x40	leuko_off	1.38333	0	No	No	No	No	0	8
159	2x38	4x38	leuko_off	1.35833	0	No	No	No	No	6	6
160	5x41	5x45	leuko_off	1.26167	0	No	No	No	No	4	5
161	4x47	4x50	leuko_off	1.17167	0	No	No	Yes	No	4	9
162	2x43	8x47	leuko_off	1.16333	0	No	Yes	No	No	7	0
163	8x52	8x55	leuko_off	1.15333	0	No	No	No	No	0	0
164	7x51	7x55	leuko_off	1.015	0	No	No	No	Yes	6	7
165	1x29	1x32	leuko_off	1.005	0	No	No	No	No	4	4
166	4x44	4x48	leuko_off	0.98	0	No	No	No	No	3	3
167	5x34	5x37	leuko_off	0.975	0	No	No	No	No	3	3
168	6x64	E3	leuko_off	0.975	0	No	No	Yes	Yes	4	4
169	1x59	8x60	leuko_off	0.903333	0	Yes	No	No	No	4	0
170	6x53	6x54	leuko_off	0.8	0	No	No	No	No	6	4
171	3x27	3x31	leuko_off	0.745	0	No	No	No	No	4	5
172	4x51	4x55	leuko_off	0.745	0	No	No	No	No	4	4
173	1x33	1x36	leuko_off	0.715	0	No	No	No	No	5	5
174	4x60	4x63	leuko_off	0.693333	0	No	No	No	No	8	4
175	5x59	5x60	leuko_off	0.691667	0	No	No	Yes	No	3	3
176	I2x51	I2x55	leuko_off	0.62	0	No	No	No	No	5	4
177	8x54	8x58	leuko_off	0.23	0	No	No	No	No	0	0
178	1x35	2x64	Shared	11.62	3.15	Yes	No	No	Yes	5	3
179	1x39	7x42	Shared	6.145	4.87	Yes	No	No	No	7	6
180	1x42	7x47	Shared	4.43833	1.71	No	No	No	No	7	7
181	1x45	7x47	Shared	4.745	6.46	No	No	No	No	5	7
182	1x50	2x50	Shared	5.41	12.12	No	Yes	Yes	Yes	9	9
183	1x50	7x50	Shared	8.96	8.15	No	Yes	No	No	9	9
184	1x55	1x59	Shared	10.2583	4.64	No	No	Yes	No	3	4
185	1x57	2x43	Shared	4.43833	3.07	Yes	Yes	No	Yes	7	7
186	1x57	2x44	Shared	6.91833	7.14	Yes	Yes	Yes	No	7	6
187	2x38	I2x57	Shared	6.54	11.77	No	No	No	No	6	7
188	2x41	4x46	Shared	3.625	1.38	No	No	No	No	6	7
189	2x45	4x46	Shared	11.2633	8.24	No	No	No	No	9	7
190	2x45	4x50	Shared	7.15667	4.52	No	No	Yes	No	9	9
191	2x46	3x42	Shared	6.09833	2.77	Yes	Yes	Yes	No	9	7
192	2x46	7x53	Shared	5.07667	3.52	Yes	Yes	Yes	Yes	9	9
193	2x49	4x50	Shared	4.17833	2.59	No	No	Yes	No	8	9
194	2x50	7x46	Shared	6.76	5.89	Yes	Yes	No	No	9	9
195	2x50	7x49	Shared	6.77	6.73	Yes	Yes	Yes	No	9	9
196	2x53	3x35	Shared	10.48	4.85	No	No	No	No	6	8
197	2x56	3x31	Shared	3.995	3.17	No	No	No	No	6	5
198	2x59	E1x52	Shared	10.5367	7.5	No	No	Yes	Yes	6	7
199	2x59	3x28	Shared	3.83167	5.59	No	No	Yes	No	6	5
200	2x60	3x29	Shared	4.525	6.79	Yes	No	No	Yes	6	6
201	2x60	Lig	Shared	7.895	18.93	Yes	No	Yes	Yes	6	0
202	2x62	2x66	Shared	20.085	14.84	No	No	No	No	3	3
203	2x62	E1x51	Shared	3.49	5.58	No	No	No	No	3	4
204	2x62	E1x52	Shared	8.53833	6.79	No	No	Yes	Yes	3	7
205	2x63	E1x50	Shared	6.54333	5.01	No	No	Yes	Yes	5	8
206	E1x49	E2	Shared	6.5	4.61	No	No	Yes	Yes	4	3
207	E1x50	E1x52	Shared	16.7033	5.01	Yes	Yes	Yes	Yes	8	7
208	3x25	E1x50	Shared	5.875	9.14	No	No	Yes	Yes	9	8
209	E1x50	E2x50	Shared	6.96667	15.67	Yes	Yes	No	No	8	9
210	E1x51	E1x52	Shared	8.15333	2.64	No	No	Yes	Yes	4	7
211	3x22	3x26	Shared	15.04	17.01	No	No	No	No	2	7
212	3x22	E2	Shared	5.30667	5.96	No	No	Yes	Yes	2	3
213	3x25	E2x50	Shared	7.28	7.28	No	No	No	No	9	9
214	3x29	4x65	Shared	14.67	14.67	No	Yes	No	No	6	5
215	3x30	3x34	Shared	6.94	3.79	Yes	No	No	Yes	5	5
216	3x30	4x62	Shared	15.4333	10.55	Yes	No	No	No	5	4
217	3x32	3x33	Shared	4.49667	1.96	Yes	No	No	No	6	4
218	3x36	6x48	Shared	6.64333	3.49	No	No	Yes	Yes	7	9
219	3x37	4x56	Shared	4.69	10.55	Yes	Yes	No	No	7	4
220	3x38	4x53	Shared	5.06333	3.42	No	No	No	No	6	8
221	3x40	5x50	Shared	6.115	3.53	No	No	Yes	Yes	8	9
222	3x41	3x44	Shared	3.64	3.64	No	No	Yes	No	5	7
223	3x41	5x50	Shared	12.4517	6.76	No	No	Yes	Yes	5	9
224	3x42	4x49	Shared	7.75833	4.28	Yes	No	No	No	7	6
225	3x44	5x50	Shared	3.49833	5.25	Yes	No	Yes	Yes	7	9
226	3x44	5x53	Shared	3.85	4.56	Yes	No	No	No	7	6
227	3x47	5x54	Shared	6.6	8.08	No	No	No	No	9	8
228	3x49	I2x57	Shared	8.935	8.34	No	No	No	No	8	7
229	3x50	5x58	Shared	3.6	7.2	Yes	No	Yes	Yes	9	8
230	3x51	5x61	Shared	3.63	3.1	No	No	No	No	8	8
231	4x39	4x43	Shared	4.27	3.71	No	No	No	No	4	4
232	4x60	5x39	Shared	4.41333	3.05	No	No	No	Yes	8	5
233	4x64	E2	Shared	11.625	18.27	No	No	Yes	Yes	4	3
234	4x64	5x35	Shared	4.065	6.53	No	No	No	No	4	2
235	4x64	5x39	Shared	3.81	4.36	No	No	No	Yes	4	5
236	4x65	E2x52	Shared	9.37	15.85	No	No	Yes	No	5	4
237	E2	E2	Shared	51.9417	35.95	Yes	Yes	Yes	Yes	3	3
238	E2x51	E2x52	Shared	6.5	4.33	No	No	Yes	No	3	4
239	E2	E2x52	Shared	4.89	8.34	Yes	Yes	Yes	No	3	4
240	5x35	E2	Shared	8.60333	5.67	No	No	Yes	Yes	2	3
241	5x36	E2	Shared	10.9067	13.38	Yes	No	Yes	Yes	4	3
242	5x33	5x36	Shared	5.815	5.82	No	No	Yes	No	3	4
243	5x33	6x62	Shared	7.18667	1.51	No	No	No	No	3	3
244	5x40	6x55	Shared	6.96333	2.75	No	No	Yes	No	4	6
245	5x40	6x59	Shared	3.53667	3.15	No	No	No	No	4	4
246	5x42	5x46	Shared	8.55	7.78	No	No	No	Yes	3	5
247	5x43	6x55	Shared	3.975	2.63	No	No	Yes	No	5	6
248	5x44	6x56	Shared	5.31333	3.15	No	No	No	No	5	5
249	5x47	5x51	Shared	9.11	6.43	No	Yes	Yes	Yes	8	6
250	5x47	6x49	Shared	4.795	3.65	No	Yes	No	No	8	6
251	5x47	6x52	Shared	13.8367	9.05	No	Yes	Yes	Yes	8	8
252	5x49	5x50	Shared	3.555	1.64	No	No	Yes	Yes	5	9
253	5x51	6x45	Shared	4.77833	2.77	Yes	Yes	No	No	6	5
254	5x65	I3	Shared	4.91333	2.43	No	No	Yes	Yes	8	4
255	I3	I3	Shared	11.225	4.28	Yes	Yes	Yes	Yes	4	4
256	6x43	7x52	Shared	3.685	2.95	No	No	No	Yes	6	8
257	6x44	6x48	Shared	11.1533	5.01	No	No	Yes	Yes	9	9
258	6x47	7x45	Shared	5.80167	5.28	Yes	No	No	No	7	9
259	6x48	7x45	Shared	8.13667	7.41	Yes	Yes	No	No	9	9
260	6x48	Lig	Shared	4.025	3.54	Yes	Yes	Yes	Yes	9	0
261	6x50	7x37	Shared	4.215	3.28	No	No	No	No	9	7
262	6x51	6x52	Shared	7.62	5.44	Yes	Yes	Yes	Yes	6	8
263	6x51	6x55	Shared	13.36	15.12	Yes	Yes	Yes	No	6	6
264	6x51	7x38	Shared	5.315	4.84	Yes	Yes	No	No	6	5
265	6x54	7x37	Shared	5.43	2.98	No	No	No	No	4	7
266	6x57	7x30	Shared	3.855	3.15	No	No	No	No	4	5
267	6x58	7x31	Shared	7.33	1.44	Yes	Yes	No	No	3	3
268	6x58	7x34	Shared	9.61	3.49	Yes	Yes	No	No	3	4
269	6x61	7x27	Shared	4.25333	3	No	No	No	No	2	3
270	E3	E3	Shared	8.13667	7.14	Yes	Yes	Yes	Yes	4	4
271	7x35	Lig	Shared	3.70833	6.83	No	No	Yes	Yes	4	0
272	7x38	Lig	Shared	7.92333	6.21	No	No	Yes	Yes	5	0
273	7x42	Lig	Shared	4.665	3.03	No	No	Yes	Yes	6	0
274	2x46	7x49	Shared	4.34833	6.87	Yes	Yes	Yes	No	9	9
275	3x33	Lig	Shared	11.565	2.13	No	No	Yes	Yes	4	0
276	3x37	Lig	Shared	3.595	4.37	Yes	Yes	Yes	Yes	7	0
277	2x50	3x39	Shared	3.46667	2.94	Yes	Yes	No	No	9	9
278	6x39	7x52	Shared	3.46	1.38	No	No	No	Yes	5	8
279	3x56	I2x52	Shared	3.45833	2.62	No	No	No	No	7	5
280	1x58	2x44	Shared	3.22667	4.15	No	No	Yes	No	3	6
281	3x37	5x46	Shared	3.12	3.75	Yes	Yes	No	Yes	7	5
282	6x40	7x52	Shared	3.09333	5.71	No	No	No	Yes	7	8
283	6x48	7x41	Shared	3.05833	5.19	Yes	Yes	No	No	9	8
284	1x39	2x61	Shared	2.99167	5.54	Yes	No	No	No	7	7
285	1x38	7x39	Shared	2.98833	3.15	No	No	No	No	5	4
286	3x48	5x53	Shared	2.935	4.28	No	No	No	No	6	6
287	5x51	5x55	Shared	2.86167	3.93	Yes	Yes	No	No	6	5
288	3x30	4x57	Shared	2.81833	2.67	Yes	No	No	No	5	7
289	2x42	3x46	Shared	2.77333	5.78	Yes	No	No	No	7	8
290	3x38	4x50	Shared	2.76833	5.19	No	No	Yes	No	6	9
291	1x50	2x51	Shared	2.75	5.49	No	Yes	No	No	9	7
292	2x39	I2x57	Shared	2.585	3.88	Yes	No	No	No	7	7
293	1x54	2x47	Shared	2.475	1.7	No	No	No	No	7	8
294	1x42	7x43	Shared	2.415	3.15	No	No	No	No	7	5
295	5x60	5x64	Shared	2.38	13.1	Yes	No	No	Yes	3	5
296	3x21	E1x50	Shared	2.34333	2.81	No	No	Yes	Yes	8	8
297	1x36	2x64	Shared	2.105	2.85	No	No	No	Yes	5	3
298	1x46	7x47	Shared	1.91	3.71	No	No	No	No	8	7
299	1x48	1x49	Shared	1.87	2.03	No	No	No	No	5	7
300	6x36	7x56	Shared	1.63	3.15	No	No	No	No	7	5
301	5x37	6x63	Shared	1.575	4.73	No	No	No	No	3	2
302	1x31	7x36	Shared	1.535	4.61	No	No	No	No	2	6
303	4x38	4x41	Shared	1.505	1.51	No	No	No	No	6	3
304	3x52	I2x53	Shared	1.5	3	No	No	No	No	5	5
305	I2x52	I2x56	Shared	1.49	1.49	No	No	No	No	5	4
306	1x37	1x41	Shared	1.47	1.54	No	No	No	No	6	5
307	I2x55	I2x56	Shared	1.41	1.41	No	No	No	No	4	4
308	3x56	I2x50	Shared	1.23	1.44	No	No	No	No	7	8
309	7x57	7x58	Shared	1.055	2.11	No	No	No	Yes	7	4
310	7x58	7x59	Shared	1.055	2.11	No	Yes	No	No	4	6
311	1x41	1x45	Shared	0.77	1.6	No	No	No	No	5	5
312	5x60	5x63	Shared	0.201667	4.76	Yes	No	No	No	3	5
313	1x29	1x30	leuko_on	0	8.16	No	No	No	No	4	3
314	1x31	7x32	leuko_on	0	2.85	No	No	No	No	2	2
315	1x33	1x37	leuko_on	0	2.85	No	No	No	No	5	6
316	1x34	7x36	leuko_on	0	4.47	No	No	No	No	5	6
317	1x39	7x39	leuko_on	0	3.15	Yes	No	No	No	7	4
318	1x43	2x57	leuko_on	0	4.73	Yes	No	No	No	6	7
319	1x47	1x48	leuko_on	0	3.28	No	No	No	No	5	5
320	1x52	1x56	leuko_on	0	7.93	No	No	No	No	6	7
321	1x52	7x55	leuko_on	0	4.29	No	No	No	Yes	6	7
322	1x52	7x62	leuko_on	0	3.21	No	No	No	Yes	6	6
323	1x53	2x47	leuko_on	0	3.39	No	No	No	No	8	8
324	1x53	7x55	leuko_on	0	2.62	No	No	No	Yes	8	7
325	1x55	1x60	leuko_on	0	6	No	No	No	No	3	5
326	1x56	1x60	leuko_on	0	2.64	No	No	No	No	7	5
327	1x56	7x62	leuko_on	0	5.27	No	No	No	Yes	7	6
328	1x57	2x40	leuko_on	0	3.25	Yes	Yes	No	No	7	7
329	1x57	7x62	leuko_on	0	6.26	Yes	Yes	No	Yes	7	6
330	I1x49	I1x50	leuko_on	0	4.07	No	No	No	No	6	6
331	2x43	7x61	leuko_on	0	4.47	No	Yes	No	No	7	7
332	2x46	3x43	leuko_on	0	4.28	Yes	Yes	No	No	9	8
333	2x46	3x46	leuko_on	0	5.65	Yes	Yes	No	No	9	8
334	2x50	7x50	leuko_on	0	3.22	Yes	Yes	No	No	9	9
335	2x52	3x35	leuko_on	0	3.42	No	No	No	No	6	8
336	2x53	7x42	leuko_on	0	2.62	No	No	No	No	6	6
337	2x53	7x46	leuko_on	0	6.46	No	No	No	No	6	9
338	2x56	3x32	leuko_on	0	6.76	No	No	Yes	No	6	6
339	2x64	Lig	leuko_on	0	11.18	No	Yes	Yes	Yes	3	0
340	3x25	3x29	leuko_on	0	4.42	No	No	No	Yes	9	6
341	3x29	4x61	leuko_on	0	4.15	No	Yes	No	No	6	4
342	3x34	4x53	leuko_on	0	4.85	No	Yes	No	No	5	8
343	3x34	4x54	leuko_on	0	6.55	No	Yes	No	No	5	3
344	3x34	4x57	leuko_on	0	3.39	No	Yes	No	No	5	7
345	3x36	Lig	leuko_on	0	5.27	No	No	Yes	Yes	7	0
346	3x37	4x53	leuko_on	0	2.54	Yes	Yes	No	No	7	8
347	3x43	7x53	leuko_on	0	6.04	No	No	Yes	Yes	8	9
348	3x46	7x53	leuko_on	0	3.59	No	No	Yes	Yes	8	9
349	3x47	5x57	leuko_on	0	3.26	No	No	No	No	9	6
350	3x47	5x58	leuko_on	0	3.82	No	No	Yes	Yes	9	8
351	3x50	7x53	leuko_on	0	8.23	Yes	No	Yes	Yes	9	9
352	3x51	5x57	leuko_on	0	6.52	No	No	No	No	8	6
353	3x55	5x64	leuko_on	0	2.77	No	No	No	Yes	7	5
354	I2x51	I2x54	leuko_on	0	3.51	No	No	No	No	5	5
355	4x52	4x56	leuko_on	0	6.92	No	No	No	No	4	4
356	4x56	5x46	leuko_on	0	2.95	No	No	No	Yes	4	5
357	4x59	4x60	leuko_on	0	3.5	No	No	No	No	4	8
358	4x61	Lig	leuko_on	0	2.78	No	No	Yes	Yes	4	0
359	4x65	E2x51	leuko_on	0	4.28	No	No	No	No	5	3
360	E2	E2x50	leuko_on	0	3.42	Yes	Yes	No	No	3	9
361	E2	E2x51	leuko_on	0	8.99	Yes	Yes	No	No	3	3
362	5x39	E2	leuko_on	0	11.98	No	Yes	Yes	Yes	5	3
363	5x36	E3	leuko_on	0	4.15	Yes	No	Yes	Yes	4	4
364	5x39	5x43	leuko_on	0	7.39	No	Yes	No	No	5	5
365	5x40	6x58	leuko_on	0	2.65	No	No	Yes	Yes	4	3
366	5x43	Lig	leuko_on	0	8.24	No	No	Yes	Yes	5	0
367	5x45	5x46	leuko_on	0	3.17	No	No	No	Yes	5	5
368	5x47	6x44	leuko_on	0	4.29	No	Yes	No	No	8	9
369	5x51	6x44	leuko_on	0	5.36	Yes	Yes	No	No	6	9
370	5x55	6x41	leuko_on	0	3.07	No	No	No	No	5	8
371	5x58	6x37	leuko_on	0	8.83	Yes	Yes	No	No	8	7
372	5x58	6x40	leuko_on	0	3.63	Yes	Yes	No	No	8	7
373	5x61	5x62	leuko_on	0	3.53	No	No	No	No	8	5
374	5x61	5x65	leuko_on	0	2.85	No	No	No	No	8	8
375	5x63	5x64	leuko_on	0	6.4	No	No	No	Yes	5	5
376	5x66	I3	leuko_on	0	3.5	No	No	Yes	Yes	5	4
377	5x68	I3	leuko_on	0	6.41	No	No	Yes	Yes	5	4
378	6x31	6x32	leuko_on	0	21.32	Yes	No	No	No	5	7
379	6x31	6x33	leuko_on	0	2.59	Yes	No	Yes	No	5	7
380	6x32	7x58	leuko_on	0	4.5	No	No	No	Yes	7	4
381	6x38	6x42	leuko_on	0	2.98	No	No	No	No	5	5
382	6x40	7x53	leuko_on	0	4.84	No	No	Yes	Yes	7	9
383	6x43	6x47	leuko_on	0	2.59	No	No	Yes	No	6	7
384	6x47	7x48	leuko_on	0	2.62	Yes	No	No	No	7	6
385	6x48	6x52	leuko_on	0	3.17	Yes	Yes	Yes	Yes	9	8
386	6x49	6x50	leuko_on	0	3.28	No	No	No	No	6	9
387	6x49	6x53	leuko_on	0	2.98	No	No	No	No	6	6
388	6x51	7x34	leuko_on	0	6.17	Yes	Yes	No	No	6	4
389	6x54	6x58	leuko_on	0	2.85	No	No	Yes	Yes	4	3
390	6x54	7x34	leuko_on	0	2.62	No	No	No	No	4	4
391	6x58	7x30	leuko_on	0	3.98	Yes	Yes	No	No	3	5
392	6x61	E3	leuko_on	0	14.02	No	No	Yes	Yes	2	4
393	6x61	7x26	leuko_on	0	7.85	No	No	No	No	2	2
394	7x55	7x62	leuko_on	0	5.34	No	Yes	No	Yes	7	6
395	7x55	I4	leuko_on	0	2.62	No	Yes	Yes	No	7	5
396	7x60	7x63	leuko_on	0	6.01	No	No	No	No	6	3
397	7x61	7x62	leuko_on	0	6.07	No	No	No	Yes	7	6
398	5x47	5x48	leuko_on	0	2.44	No	Yes	No	No	8	4
399	2x41	I1x51	leuko_on	0	2.43	No	No	No	No	6	6
400	6x32	6x35	leuko_on	0	2.13	No	No	No	No	7	6
401	3x23	3x24	leuko_on	0	1.95	No	No	No	No	1	5
402	4x47	4x48	leuko_on	0	1.95	No	No	No	No	4	3
403	7x64	I4	leuko_on	0	1.95	No	No	Yes	No	5	5
404	3x37	3x41	leuko_on	0	1.93	Yes	Yes	No	No	7	5
405	2x57	2x58	leuko_on	0	1.87	No	No	No	No	7	9
406	5x32	5x34	leuko_on	0	1.86	No	No	No	No	4	3
407	7x57	7x63	leuko_on	0	1.86	No	No	No	No	7	3
408	4x48	4x51	leuko_on	0	1.84	No	No	No	No	3	4
409	1x53	7x50	leuko_on	0	1.77	No	No	No	No	8	9
410	1x46	2x54	leuko_on	0	1.71	No	No	No	No	8	5
411	6x36	7x58	leuko_on	0	1.71	No	No	No	Yes	7	4
412	1x46	1x50	leuko_on	0	1.7	No	No	No	Yes	8	9
413	2x43	7x54	leuko_on	0	1.7	No	Yes	No	No	7	6
414	3x45	4x49	leuko_on	0	1.62	No	No	No	No	6	6
415	5x41	6x59	leuko_on	0	1.62	No	No	No	No	4	4
416	2x40	I1x48	leuko_on	0	1.61	No	No	No	No	7	6
417	2x39	2x43	leuko_on	0	1.59	Yes	No	No	Yes	7	7
418	5x461	6x52	leuko_on	0	1.59	No	No	Yes	Yes	5	8
419	2x57	2x61	leuko_on	0	1.58	No	No	No	No	7	7
420	1x36	1x40	leuko_on	0	1.55	No	No	No	No	5	5
421	4x45	4x49	leuko_on	0	1.54	No	No	No	No	5	6
422	1x32	2x64	leuko_on	0	1.5	No	No	No	Yes	4	3
423	4x38	4x39	leuko_on	0	1.5	No	No	No	No	6	4
424	1x38	7x36	leuko_on	0	1.49	No	No	No	No	5	6
425	1x54	2x48	leuko_on	0	1.49	No	No	No	No	7	5
426	5x44	6x52	leuko_on	0	1.46	No	No	Yes	Yes	5	8
427	I2x50	I2x51	leuko_on	0	1.44	No	No	No	No	8	5
428	5x32	5x33	leuko_on	0	1.44	No	No	No	No	4	3
429	2x41	4x39	leuko_on	0	1.41	No	No	No	No	6	4
430	4x41	I2x56	leuko_on	0	1.41	No	No	No	No	3	4
431	1x38	7x40	leuko_on	0	1.38	No	No	No	No	5	8
432	1x47	2x51	leuko_on	0	1.38	No	No	No	No	5	7
433	2x40	I1x51	leuko_on	0	1.38	No	No	No	No	7	6
434	6x36	7x52	leuko_on	0	1.38	No	No	No	Yes	7	8
435	7x40	7x43	leuko_on	0	1.38	No	No	No	No	8	5
436	3x54	5x64	leuko_on	0	1.31	No	No	No	Yes	8	5
437	7x29	E3	leuko_on	0	1.21	No	No	Yes	Yes	3	4

Orange: nodes, hubs and links specific of leuko_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of leuko_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	leuko_off Avg Int. Strength	leuko_on Avg Int. Strength	leuko_off Num Of Links	leuko_on Num Of Links	ConSurf
1	1x35	leuko_off	6.91125	3.15	4	1	5
2	1x39	leuko_off	5.089	4.52	5	3	7
3	1x43	leuko_off	4.89417	4.73	4	1	6
4	1x59	leuko_off	3.69833	4.64	4	1	4
5	2x37	leuko_off	3.92833	0	4	0	7
6	2x39	leuko_off	3.96208	2.735	4	2	7
7	2x42	leuko_off	3.2	5.78	4	1	7
8	2x44	leuko_off	4.565	5.645	4	2	6
9	2x60	leuko_off	5.45306	12.86	6	2	6
10	3x28	leuko_off	3.83667	5.59	4	1	5
11	3x30	leuko_off	6.23111	5.67	6	3	5
12	3x32	leuko_off	4.05125	4.36	4	2	6
13	3x42	leuko_off	5.57417	3.525	4	2	7
14	3x44	leuko_off	3.83333	4.48333	4	3	7
15	3x50	leuko_off	3.84167	7.715	4	2	9
16	4x50	leuko_off	3.82367	4.1	5	3	9
17	E2x52	leuko_off	6.24208	9.50667	4	3	4
18	5x36	leuko_off	6.75833	7.78333	4	3	4
19	5x60	leuko_off	3.073	8.93	5	2	3
20	6x31	leuko_off	2.82958	11.955	4	2	5
21	6x33	leuko_off	2.90708	2.59	4	1	7
22	6x47	leuko_off	3.85458	3.49667	4	3	7
23	6x55	leuko_off	7.47028	6.83333	6	3	6
24	7x49	leuko_off	5.19708	6.8	4	2	9
25	I4	leuko_off	10.6118	2.285	11	2	5
26	1x57	Shared	4.62167	4.93	4	4	7
27	2x46	Shared	4.96792	4.618	4	5	9
28	2x50	Shared	5.351	6.18	5	5	9
29	E1x50	Shared	6.32167	7.528	8	5	8
30	E1x52	Shared	10.9829	5.485	4	4	7
31	3x37	Shared	3.73167	4.628	5	5	7
32	E2	Shared	14.9868	13.8655	11	11	3
33	5x50	Shared	6.405	4.295	4	4	9
34	5x51	Shared	5.05333	4.6225	5	4	6
35	5x58	Shared	4.16	5.87	5	4	8
36	I3	Shared	7.18708	4.18	4	5	4
37	6x48	Shared	6.20738	4.635	7	6	9
38	6x51	Shared	6.74733	7.8925	5	4	6
39	6x52	Shared	7.46583	4.142	4	5	8
40	6x58	Shared	6.125	2.882	4	5	3
41	E3	Shared	4.97389	6.732	6	5	4
42	7x53	Shared	5.52208	5.244	4	5	9
43	Lig	Shared	6.32952	6.59182	14	11	0
44	1x50	leuko_on	5.70667	6.865	3	4	9
45	2x43	leuko_on	3.97222	2.7075	3	4	7
46	2x64	leuko_on	6.175	4.67	3	4	3
47	3x29	leuko_on	10.4406	7.5075	3	4	6
48	3x34	leuko_on	6.94	4.645	1	4	5
49	5x39	leuko_on	4.11167	6.695	2	4	5
50	5x46	leuko_on	5.835	4.4125	2	4	5
51	5x47	leuko_on	9.24722	5.172	3	5	8
52	5x64	leuko_on	2.38	5.895	1	4	5
53	7x52	leuko_on	3.41278	2.855	3	4	8
54	7x55	leuko_on	3.0875	3.7175	2	4	7
55	7x58	leuko_on	1.20333	2.6075	3	4	4
56	7x62	leuko_on	7.59	5.23	2	5	6

Orange: nodes, hubs and links specific of leuko_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of leuko_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	leuko_off Recurrence	leuko_on Recurrence	leuko_off Hub1?	leuko_on Hub1?	leuko_off Hub2?	leuko_on Hub2?	ConSurf1	ConSurf2
1	6x58	7x31	leuko_off	10.4454	3.39067	Yes	Yes	No	No	3	3
2	5x36	6x58	leuko_off	22.6479	0	Yes	No	Yes	Yes	4	3
3	E1x50	E2	leuko_off	22.2086	0	Yes	Yes	Yes	Yes	8	3
4	5x36	Lig	leuko_off	25.7738	0	Yes	No	Yes	Yes	4	0
5	7x35	Lig	leuko_off	12.3251	2.16489	No	No	Yes	Yes	4	0
6	1x35	7x35	leuko_off	11.3188	0	Yes	No	No	No	5	4
7	6x47	7x43	leuko_off	10.4352	0	Yes	No	No	No	7	5
8	7x45	7x49	leuko_off	100	0	No	No	Yes	No	9	9
9	1x57	7x53	leuko_off	25.9117	0	Yes	Yes	Yes	Yes	7	9
10	1x57	2x44	leuko_off	15.3744	5.10083	Yes	Yes	Yes	No	7	6
11	6x40	7x49	leuko_off	78.3737	0	No	No	Yes	No	7	9
12	6x36	6x40	leuko_off	74.4152	0	No	No	No	No	7	7
13	6x36	I4	leuko_off	72.6019	0	No	No	Yes	No	7	5
14	2x39	I4	leuko_off	61.1145	0	Yes	No	Yes	No	7	5
15	3x32	Lig	leuko_off	11.0175	0	Yes	No	Yes	Yes	6	0
16	2x53	3x32	leuko_off	14.6695	0	No	No	Yes	No	6	6
17	2x53	3x35	leuko_off	13.556	5.44682	No	No	No	No	6	8
18	2x49	3x35	leuko_off	13.2751	0	No	No	No	No	8	8
19	2x49	4x50	leuko_off	13.0453	2.42191	No	No	Yes	No	8	9
20	2x45	3x42	leuko_off	13.9391	0	No	No	Yes	No	9	7
21	2x60	3x28	leuko_off	10.3943	0	Yes	No	Yes	No	6	5
22	3x33	Lig	leuko_off	10.5169	9.95453	No	No	Yes	Yes	4	0
23	3x33	4x61	leuko_off	10.4863	0	No	No	No	No	4	4
24	3x36	6x48	leuko_off	11.5998	0.652432	No	No	Yes	Yes	7	9
25	3x36	6x51	leuko_off	10.5322	0	No	No	Yes	Yes	7	6
26	3x40	6x48	leuko_off	16.1201	0	No	No	Yes	Yes	8	9
27	3x40	5x50	leuko_off	14.7053	2.45156	No	No	Yes	Yes	8	9
28	2x39	3x50	leuko_off	56.3949	0	Yes	No	Yes	No	7	9
29	5x58	6x38	leuko_off	39.0796	0	Yes	Yes	No	No	8	5
30	5x61	6x38	leuko_off	36.73	0	No	No	No	No	8	5
31	3x51	3x55	leuko_off	17.6065	0	No	No	No	No	8	7
32	6x52	6x55	leuko_off	10.1287	0	Yes	Yes	Yes	No	8	6
33	5x47	5x51	leuko_off	14.0311	0.899565	No	Yes	Yes	Yes	8	6
34	6x58	6x61	leuko_off	13.8421	0	Yes	Yes	No	No	3	2
35	1x57	8x50	leuko_off	10.3994	0	Yes	Yes	No	No	7	0
36	3x55	3x56	leuko_off	16.2121	0	No	No	No	No	7	7
37	3x56	I2x52	leuko_off	13.3926	9.95453	No	No	No	No	7	5
38	3x50	6x33	leuko_off	11.7632	0	Yes	No	Yes	No	9	7
39	E2	Lig	leuko_off	28.721	0	Yes	Yes	Yes	Yes	3	0
40	6x55	Lig	leuko_off	23.5724	0	Yes	No	Yes	Yes	6	0
41	2x60	Lig	Shared	13.0861	29.6066	Yes	No	Yes	Yes	6	0
42	6x48	Lig	Shared	90.4127	75.2669	Yes	Yes	Yes	Yes	9	0
43	6x48	7x45	Shared	93.5233	51.5915	Yes	Yes	No	No	9	9
44	2x50	7x49	Shared	18.3063	49.9802	Yes	Yes	Yes	No	9	9
45	2x50	7x46	Shared	10.4352	82.7798	Yes	Yes	No	No	9	9
46	2x46	7x49	Shared	44.9842	48.3887	Yes	Yes	Yes	No	9	9
47	2x46	7x53	Shared	31.0399	35.5971	Yes	Yes	Yes	Yes	9	9
48	2x45	4x46	Shared	20.14	27.7086	No	No	No	No	9	7
49	2x41	4x46	Shared	10.1083	26.5322	No	No	No	No	6	7
50	2x46	3x42	Shared	21.0951	11.1408	Yes	Yes	Yes	No	9	7
51	3x37	Lig	Shared	19.7467	65.3223	Yes	Yes	Yes	Yes	7	0
52	3x50	5x58	Shared	45.6124	11.9612	Yes	No	Yes	Yes	9	8
53	3x51	5x61	Shared	27.0814	20.5121	No	No	No	No	8	8
54	5x40	6x55	Shared	10.614	15.1246	No	No	Yes	No	4	6
55	5x47	6x52	Shared	21.0185	14.0075	No	Yes	Yes	Yes	8	8
56	1x38	7x36	leuko_on	0	11.8723	No	No	No	No	5	6
57	1x45	7x47	leuko_on	4.5306	10.429	No	No	No	No	5	7
58	1x38	7x39	leuko_on	1.57319	17.2005	No	No	No	No	5	4
59	1x39	7x39	leuko_on	0	19.6422	Yes	No	No	No	7	4
60	1x39	7x42	leuko_on	4.90857	31.7517	Yes	No	No	No	7	6
61	7x42	Lig	leuko_on	6.09868	100	No	No	Yes	Yes	6	0
62	2x64	Lig	leuko_on	0	11.724	No	Yes	Yes	Yes	3	0
63	1x39	2x61	leuko_on	5.5215	10.8244	Yes	No	No	No	7	7
64	1x46	7x47	leuko_on	1.51701	17.3982	No	No	No	No	8	7
65	1x46	1x50	leuko_on	0	22.1036	No	No	No	Yes	8	9
66	1x50	2x51	leuko_on	3.02891	10.429	No	Yes	No	No	9	7
67	2x53	7x42	leuko_on	0	85.2313	No	No	No	No	6	6
68	2x53	7x46	leuko_on	0	83.1257	No	No	No	No	6	9
69	2x50	7x50	leuko_on	0	68.5943	Yes	Yes	No	No	9	9
70	1x53	7x50	leuko_on	0	76.038	No	No	No	No	8	9
71	1x53	7x55	leuko_on	0	69.1874	No	No	No	Yes	8	7
72	1x52	7x55	leuko_on	0	10.9035	No	No	No	Yes	6	7
73	7x55	7x62	leuko_on	0	53.4599	No	Yes	No	Yes	7	6
74	1x56	7x62	leuko_on	0	10.3401	No	No	No	Yes	7	6
75	1x56	1x60	leuko_on	0	14.3733	No	No	No	No	7	5
76	1x57	7x62	leuko_on	0	30.7038	Yes	Yes	No	Yes	7	6
77	1x57	2x40	leuko_on	0	15.8264	Yes	Yes	No	No	7	7
78	1x57	2x43	leuko_on	0.127694	14.9664	Yes	Yes	No	Yes	7	7
79	7x61	7x62	leuko_on	0	14.7786	No	No	No	Yes	7	6
80	2x43	7x61	leuko_on	0	12.5544	No	Yes	No	No	7	7
81	2x39	2x43	leuko_on	0	17.9221	Yes	No	No	Yes	7	7
82	2x39	I2x57	leuko_on	6.8342	13.2859	Yes	No	No	No	7	7
83	3x37	4x53	leuko_on	0	44.0589	Yes	Yes	No	No	7	8
84	3x38	4x53	leuko_on	1.66513	34.0945	No	No	No	No	6	8
85	3x38	4x50	leuko_on	3.32516	32.4338	No	No	Yes	No	6	9
86	2x45	4x50	leuko_on	8.23884	29.2112	No	No	Yes	No	9	9
87	2x60	3x29	leuko_on	0.326898	28.2127	Yes	No	No	Yes	6	6
88	3x25	3x29	leuko_on	0	41.469	No	No	No	Yes	9	6
89	3x25	E1x50	leuko_on	1.68046	33.8869	No	No	Yes	Yes	9	8
90	E1x50	E1x52	leuko_on	8.57595	24.9605	Yes	Yes	Yes	Yes	8	7
91	4x61	Lig	leuko_on	0	29.824	No	No	Yes	Yes	4	0
92	3x29	4x61	leuko_on	0	28.5389	No	Yes	No	No	6	4
93	5x43	Lig	leuko_on	0	54.1222	No	No	Yes	Yes	5	0
94	5x39	5x43	leuko_on	0	47.6473	No	Yes	No	No	5	5
95	5x39	E2	leuko_on	0	38.4045	No	Yes	Yes	Yes	5	3
96	3x29	4x65	leuko_on	0.0510777	12.0206	No	Yes	No	No	6	5
97	3x34	4x53	leuko_on	0	12.0008	No	Yes	No	No	5	8
98	3x37	3x41	leuko_on	0	16.8051	Yes	Yes	No	No	7	5
99	3x50	7x53	leuko_on	0	13.4243	Yes	No	Yes	Yes	9	9
100	3x47	5x58	leuko_on	0	34.0747	No	No	Yes	Yes	9	8
101	6x40	7x53	leuko_on	0	26.5322	No	No	Yes	Yes	7	9
102	5x58	6x40	leuko_on	0	30.7335	Yes	Yes	No	No	8	7
103	6x47	7x45	leuko_on	6.62989	49.8715	Yes	No	No	No	7	9
104	6x43	6x47	leuko_on	0	47.3408	No	No	Yes	No	6	7
105	6x43	7x52	leuko_on	3.01869	46.5599	No	No	No	Yes	6	8
106	6x40	7x52	leuko_on	6.00163	36.4472	No	No	No	Yes	7	8
107	3x47	5x57	leuko_on	0	27.3329	No	No	No	No	9	6
108	3x51	5x57	leuko_on	0	23.9324	No	No	No	No	8	6
109	2x41	4x39	leuko_on	0	25.8897	No	No	No	No	6	4
110	4x38	4x39	leuko_on	0	21.5994	No	No	No	No	6	4
111	4x38	4x41	leuko_on	1.5119	19.2369	No	No	No	No	6	3
112	4x41	I2x56	leuko_on	0	16.8545	No	No	No	No	3	4
113	I2x52	I2x56	leuko_on	7.93237	12.3962	No	No	No	No	5	4
114	5x36	E2	leuko_on	4.60721	23.8434	Yes	No	Yes	Yes	4	3
115	5x36	E3	leuko_on	0	11.981	Yes	No	Yes	Yes	4	4
116	5x43	6x55	leuko_on	1.3791	19.1677	No	No	Yes	No	5	6
117	7x38	Lig	leuko_on	3.69803	13.3155	No	No	Yes	Yes	5	0
118	6x51	7x38	leuko_on	2.56921	11.3484	Yes	Yes	No	No	6	5
119	6x51	7x34	leuko_on	0	14.1953	Yes	Yes	No	No	6	4
120	6x48	6x52	leuko_on	0	24.6738	Yes	Yes	Yes	Yes	9	8
121	6x44	6x48	leuko_on	1.5119	22.6572	No	No	Yes	Yes	9	9
122	5x47	6x44	leuko_on	0	11.6153	No	Yes	No	No	8	9
123	5x47	6x49	leuko_on	3.50393	15.3717	No	Yes	No	No	8	6
124	5x61	5x65	leuko_on	0	13.6121	No	No	No	No	8	8
125	5x65	I3	leuko_on	3.01869	10.1127	No	No	Yes	Yes	8	4
126	6x36	7x52	leuko_on	0	26.3938	No	No	No	Yes	7	8
127	6x36	7x58	leuko_on	0	21.9059	No	No	No	Yes	7	4
128	6x32	7x58	leuko_on	0	10.0633	No	No	No	Yes	7	4
129	2x41	I1x51	leuko_on	0	17.0819	No	No	No	No	6	6
130	1x50	2x50	leuko_on	8.97436	24.486	No	Yes	Yes	Yes	9	9
131	2x40	I1x51	leuko_on	0	16.4788	No	No	No	No	7	6

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
1x35	2x64	Shared	11.62	3.15	0	0	2	1
1x39	2x60	leuko_off	5.24	0	0	0	2	1
1x39	7x42	Shared	6.145	4.87	0	0	2	1
2x53	3x32	leuko_off	4.34833	0	0	0	2	1
2x60	3x28	leuko_off	3.54167	0	1	0	1	2
2x60	3x29	Shared	4.525	6.79	1	0	1	1
2x60	3x32	leuko_off	3.62	0	1	0	1	1
2x60	Lig	Shared	7.895	18.93	1	0	1	0
2x63	E1x50	Shared	6.54333	5.01	0	0	2	2
E1x49	E2	Shared	6.5	4.61	0	0	2	1
3x25	E1x50	Shared	5.875	9.14	1	1	2	2
3x28	E1x50	leuko_off	4.86833	0	0	0	2	2
E1x50	E2	leuko_off	4.84	0	1	1	2	1
E1x50	E2x50	Shared	6.96667	15.67	1	1	2	2
3x22	E2	Shared	5.30667	5.96	1	1	2	1
3x25	E2x50	Shared	7.28	7.28	1	1	2	2
3x29	4x65	Shared	14.67	14.67	1	0	1	1
3x29	Lig	leuko_off	12.1267	0	1	0	1	0
3x32	3x33	Shared	4.49667	1.96	1	0	1	1
3x32	Lig	leuko_off	3.74	0	1	0	1	0
3x36	6x48	Shared	6.64333	3.49	0	2	1	1
3x36	6x51	leuko_off	4.19	0	0	2	1	2
3x37	4x56	Shared	4.69	10.55	0	2	1	2
3x37	5x461	leuko_off	3.625	0	0	2	1	2
4x64	E2	Shared	11.625	18.27	1	1	2	1
4x64	5x35	Shared	4.065	6.53	1	1	2	2
4x64	5x39	Shared	3.81	4.36	1	1	2	2
4x65	E2x52	Shared	9.37	15.85	1	1	1	1
4x65	Lig	leuko_off	6.085	0	1	1	1	0
E2	E2	Shared	51.9417	35.95	1	1	1	1
E2x51	E2x52	Shared	6.5	4.33	0	1	2	1
E2	E2x52	Shared	4.89	8.34	1	1	1	1
E2x52	Lig	leuko_off	4.20833	0	1	1	1	0
5x35	E2	Shared	8.60333	5.67	1	1	2	1
5x36	E2	Shared	10.9067	13.38	1	1	1	1
5x33	5x36	Shared	5.815	5.82	0	0	2	1
5x33	6x62	Shared	7.18667	1.51	0	0	2	2
5x36	6x58	leuko_off	4.65	0	1	1	1	2
5x40	6x55	Shared	6.96333	2.75	0	0	2	1
5x43	6x55	Shared	3.975	2.63	0	0	1	1
6x44	6x48	Shared	11.1533	5.01	0	2	2	1
6x47	6x48	leuko_off	3.52667	0	1	0	2	1
6x47	7x45	Shared	5.80167	5.28	1	0	2	2
6x48	7x45	Shared	8.13667	7.41	1	2	1	2
6x48	Lig	Shared	4.025	3.54	1	2	1	0
6x51	6x52	Shared	7.62	5.44	1	0	2	2
6x51	6x55	Shared	13.36	15.12	1	0	2	1
6x51	7x38	Shared	5.315	4.84	1	0	2	1
6x52	6x55	leuko_off	4.77833	0	1	0	2	1
6x55	7x34	leuko_off	6.83333	0	1	0	1	2
6x58	7x34	Shared	9.61	3.49	0	8	2	2
E3	E3	Shared	8.13667	7.14	4	1	2	2
7x35	Lig	Shared	3.70833	6.83	0	0	1	0
7x38	Lig	Shared	7.92333	6.21	0	0	1	0
7x42	Lig	Shared	4.665	3.03	0	0	1	0
1x35	1x39	leuko_off	7.735	0	0	0	2	2
1x35	7x35	leuko_off	4.15333	0	0	0	2	1
2x60	E2x51	leuko_off	7.89667	0	1	0	1	2
2x63	2x64	leuko_off	4.8	0	0	0	2	1
3x33	Lig	Shared	11.565	2.13	1	0	1	0
3x37	6x52	leuko_off	3.62833	0	0	2	1	2
3x37	Lig	Shared	3.595	4.37	0	2	1	0
3x40	6x48	leuko_off	6.90833	0	0	0	2	1
6x62	E2	leuko_off	3.79667	0	1	0	2	1
E2	Lig	leuko_off	4.50333	0	1	1	1	0
5x36	Lig	leuko_off	5.66167	0	1	1	1	0
6x55	Lig	leuko_off	8.91167	0	1	0	1	0
3x37	5x46	Shared	3.12	3.75	0	2	1	2
2x56	3x28	leuko_off	3.105	0	0	0	2	2
6x48	7x41	Shared	3.05833	5.19	1	2	1	2
3x33	4x61	leuko_off	2.735	0	1	0	1	1
3x30	4x61	leuko_off	2.285	0	0	6	2	1
1x36	2x64	Shared	2.105	2.85	0	0	2	1
2x53	7x42	leuko_on	0	2.62	0	0	2	1
2x56	3x32	leuko_on	0	6.76	0	0	2	1
2x64	Lig	leuko_on	0	11.18	0	0	1	0
3x25	3x29	leuko_on	0	4.42	1	1	2	1
3x29	4x61	leuko_on	0	4.15	1	0	1	1
3x36	Lig	leuko_on	0	5.27	0	2	1	0
3x37	4x53	leuko_on	0	2.54	0	2	1	2
4x56	5x46	leuko_on	0	2.95	0	2	2	2
4x61	Lig	leuko_on	0	2.78	0	0	1	0
4x65	E2x51	leuko_on	0	4.28	1	1	1	2
E2	E2x50	leuko_on	0	3.42	1	1	1	2
E2	E2x51	leuko_on	0	8.99	1	1	1	2
5x39	E2	leuko_on	0	11.98	0	1	2	1
5x36	E3	leuko_on	0	4.15	1	1	1	2
5x39	5x43	leuko_on	0	7.39	0	1	2	1
5x40	6x58	leuko_on	0	2.65	0	0	2	2
5x43	Lig	leuko_on	0	8.24	0	0	1	0
6x48	6x52	leuko_on	0	3.17	1	2	1	2
6x51	7x34	leuko_on	0	6.17	1	0	2	2
3x37	3x41	leuko_on	0	1.93	0	2	1	2
5x461	6x52	leuko_on	0	1.59	0	0	2	2
1x32	2x64	leuko_on	0	1.5	0	0	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	leuko_off	blt_off cyslt_off
	leuko_on	blt_on

Network Difference
Value	leuko_off	leuko_on
I_min	3.485	2.54
Number of Linked Nodes	278	235
Number of Specific Nodes	49 (17.63%)	6 (2.55%)
Number of Shared Nodes	229 (82.37%)	229 (97.45%)
Number of Links	312	260
Number of Specific Links	177 (56.73%)	125 (48.08%)
Number of Shared Links	135 (43.27%)	135 (51.92%)
Number of Hubs	43	31
Number of Specific Hubs	25 (58.14%)	13 (41.94%)
Number of Shared Hubs	18 (41.86%)	18 (58.06%)
Average % Shared Neighbours (Jaccard)	29.82
Average % Shared Neighbours (Otsuka)	38.60
Average % Shared Neighbours (Overlap Coefficient)	47.81
Average % Shared Cliques (k3-6)	78.03
Graphlets Similarity	0.516211

Paths Difference
Value	leuko_off	leuko_on
Number Of Nodes in MetaPath	57	86
Specific Nodes in MetaPath	22 (38.60%)	51 (59.30%)
Shared Nodes in MetaPath	229 (82.37%)	229 (82.37%)
Number Of Links MetaPath	55	91
Specific Links in MetaPath	40 (72.73%)	76 (83.52%)
Shared Links in MetaPath	135 (43.27%)	135 (43.27%)
Number of Shortest Paths	42602	31749
Length Of Smallest Path	3	3
Average Path Length	11.4041	11.4882
Length of Longest Path	28	30
Minimum Path Strength	0.446667	1.38
Average Path Strength	5.18411	4.87364
Maximum Path Strength	15.1089	15.825
Minimum Path Correlation	0.7	0.7
Average Path Correlation	0.912325	0.922016
Maximum Path Correlation	0.993333	0.99
Minimum % Of Corr. Nodes	4	4.34783
Average % Of Corr. Nodes	47.5015	53.2743
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	49.1057	36.5553
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

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