psnGPCR

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Orange: nodes, hubs and links specific of leukotriene_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of leukotriene_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	leukotriene_off Int. Strength	leukotriene_on Int. Strength	leukotriene_off Hub1?	leukotriene_on Hub1?	leukotriene_off Hub2?	leukotriene_on Hub2?	ConSurf1	ConSurf2
1	1x30	1x34	leukotriene_off	4.80208	0	Yes	No	No	No	4	5
2	1x39	2x60	leukotriene_off	5.755	0	Yes	No	Yes	No	7	6
3	1x43	1x47	leukotriene_off	3.86	0	Yes	No	No	No	5	5
4	1x43	2x58	leukotriene_off	6.80917	0	Yes	No	No	No	5	9
5	1x49	7x50	leukotriene_off	3.72167	0	No	No	No	No	7	9
6	1x53	7x53	leukotriene_off	5.95833	0	No	No	Yes	Yes	8	9
7	1x59	1x60	leukotriene_off	4.88667	0	No	No	No	No	4	5
8	2x41	4x43	leukotriene_off	8.52917	0	No	No	No	No	7	4
9	2x43	7x53	leukotriene_off	5.49875	0	No	Yes	Yes	Yes	8	9
10	2x45	3x42	leukotriene_off	5.96333	0	No	No	Yes	No	9	7
11	2x53	Lig	leukotriene_off	4.3	0	No	No	Yes	Yes	6	0
12	2x54	7x46	leukotriene_off	5.4225	0	No	No	No	No	5	9
13	2x60	3x32	leukotriene_off	4.88625	0	Yes	No	No	No	6	6
14	2x66	E1x51	leukotriene_off	5.79667	0	No	No	No	No	3	3
15	3x28	E1x50	leukotriene_off	4.535	0	No	No	Yes	Yes	4	8
16	3x29	Lig	leukotriene_off	8.07708	0	No	Yes	Yes	Yes	5	0
17	3x30	4x54	leukotriene_off	4.8825	0	No	No	No	No	4	3
18	3x32	Lig	leukotriene_off	4.24	0	No	No	Yes	Yes	6	0
19	3x37	5x461	leukotriene_off	3.625	0	Yes	Yes	No	No	7	6
20	3x41	4x49	leukotriene_off	4.84	0	No	No	No	No	6	7
21	3x43	6x41	leukotriene_off	4.5575	0	No	No	No	No	8	7
22	3x44	5x54	leukotriene_off	4.22833	0	No	No	No	No	7	8
23	3x51	5x60	leukotriene_off	6.96833	0	Yes	No	No	No	8	4
24	3x54	5x61	leukotriene_off	4.17208	0	No	No	No	No	8	8
25	5x58	6x38	leukotriene_off	11.5304	0	Yes	Yes	No	No	9	4
26	6x31	I3	leukotriene_off	5.595	0	Yes	No	Yes	Yes	4	4
27	6x55	7x34	leukotriene_off	4.60667	0	Yes	No	No	No	5	4
28	3x51	3x55	leukotriene_off	4.1125	0	Yes	No	No	No	8	7
29	5x58	6x41	leukotriene_off	3.78	0	Yes	Yes	No	No	9	7
30	6x52	6x55	leukotriene_off	3.89333	0	Yes	Yes	Yes	No	8	5
31	6x61	7x30	leukotriene_off	5.15	0	No	No	No	No	2	4
32	CT	CT	leukotriene_off	17.0175	0	Yes	No	Yes	No	0	0
33	E2	Lig	leukotriene_off	4.8325	0	Yes	Yes	Yes	Yes	3	0
34	5x39	Lig	leukotriene_off	3.78542	0	No	Yes	Yes	Yes	4	0
35	6x55	Lig	leukotriene_off	9.0625	0	Yes	No	Yes	Yes	5	0
36	1x27	7x31	leukotriene_off	5.74125	0	No	No	No	No	0	4
37	1x30	7x32	leukotriene_off	5.79042	0	Yes	No	No	No	4	3
38	1x35	1x39	leukotriene_off	7.0175	0	No	No	Yes	No	5	7
39	1x35	7x35	leukotriene_off	6.5525	0	No	No	No	No	5	3
40	2x42	3x49	leukotriene_off	4.335	0	No	No	No	No	7	8
41	2x60	E2x51	leukotriene_off	9.62208	0	Yes	No	No	No	6	3
42	2x63	2x64	leukotriene_off	5.62625	0	No	No	No	Yes	5	5
43	2x63	E1	leukotriene_off	4.26125	0	No	No	No	No	5	0
44	3x33	4x61	leukotriene_off	5.04125	0	No	No	No	No	4	4
45	3x37	6x52	leukotriene_off	3.94625	0	Yes	Yes	Yes	Yes	7	8
46	3x40	6x48	leukotriene_off	7.27458	0	No	No	Yes	Yes	7	9
47	3x42	4x50	leukotriene_off	4.76	0	Yes	No	Yes	No	7	9
48	E2x50	E2x51	leukotriene_off	4.85625	0	No	No	No	No	9	3
49	5x40	6x56	leukotriene_off	4.05125	0	Yes	No	No	No	5	5
50	5x65	6x31	leukotriene_off	3.64167	0	No	No	Yes	No	8	4
51	6x45	6x48	leukotriene_off	4.24292	0	No	No	Yes	Yes	5	9
52	3x55	3x56	leukotriene_off	3.84292	0	No	No	No	No	7	5
53	4x39	I1	leukotriene_off	4.15708	0	No	No	Yes	No	4	0
54	6x47	7x43	leukotriene_off	3.555	0	Yes	No	No	No	7	5
55	1x34	1x38	leukotriene_off	3.54625	0	No	No	No	No	5	5
56	2x40	I1	leukotriene_off	3.51917	0	No	No	Yes	No	7	0
57	3x50	6x37	leukotriene_off	3.5175	0	Yes	No	No	No	9	7
58	7x49	7x53	leukotriene_off	3.48917	0	No	No	Yes	Yes	9	9
59	2x42	3x45	leukotriene_off	3.485	0	No	No	No	No	7	6
60	8x53	I1	leukotriene_off	3.44	0	No	No	Yes	No	0	0
61	6x43	7x48	leukotriene_off	3.38	0	No	No	No	No	6	7
62	3x46	6x37	leukotriene_off	3.35083	0	No	No	No	No	8	7
63	3x50	6x34	leukotriene_off	3.28708	0	Yes	No	No	No	9	5
64	7x62	CT	leukotriene_off	3.27	0	No	Yes	Yes	No	0	0
65	5x68	6x30	leukotriene_off	3.1975	0	No	No	No	No	5	6
66	1x39	2x57	leukotriene_off	3.1325	0	Yes	No	No	No	7	7
67	1x36	2x65	leukotriene_off	3.12833	0	No	No	No	No	6	5
68	8x49	I1	leukotriene_off	3.10417	0	No	No	Yes	No	0	0
69	2x39	CT	leukotriene_off	3.0325	0	No	No	Yes	No	7	0
70	2x56	3x28	leukotriene_off	2.9975	0	No	No	No	No	6	4
71	2x39	3x50	leukotriene_off	2.95667	0	No	No	Yes	No	7	9
72	5x45	5x48	leukotriene_off	2.93875	0	No	No	No	No	4	4
73	1x54	2x44	leukotriene_off	2.93208	0	No	No	No	No	7	6
74	7x54	7x55	leukotriene_off	2.88542	0	No	No	No	Yes	7	7
75	5x65	6x30	leukotriene_off	2.805	0	No	No	No	No	8	6
76	1x31	E2x52	leukotriene_off	2.77125	0	No	No	No	No	3	5
77	1x40	2x61	leukotriene_off	2.77	0	No	No	No	No	4	7
78	2x41	4x42	leukotriene_off	2.7275	0	No	No	No	No	7	7
79	6x54	7x33	leukotriene_off	2.70542	0	No	No	No	No	4	5
80	3x24	E1x50	leukotriene_off	2.69917	0	No	No	Yes	Yes	5	8
81	2x44	2x48	leukotriene_off	2.6575	0	No	No	No	No	6	5
82	7x25	7x26	leukotriene_off	2.59	0	No	No	No	No	0	1
83	2x37	CT	leukotriene_off	2.5825	0	No	No	Yes	No	7	0
84	1x30	7x35	leukotriene_off	2.56667	0	Yes	No	No	No	4	3
85	1x28	1x31	leukotriene_off	2.545	0	No	No	No	No	0	3
86	3x23	3x27	leukotriene_off	2.52583	0	No	No	No	No	3	4
87	1x52	1x55	leukotriene_off	2.505	0	No	No	No	No	6	4
88	7x61	CT	leukotriene_off	2.4875	0	No	No	Yes	No	0	0
89	1x26	7x28	leukotriene_off	2.48708	0	No	No	No	No	0	3
90	3x50	6x33	leukotriene_off	2.47583	0	Yes	No	No	No	9	7
91	1x50	2x47	leukotriene_off	2.47458	0	Yes	Yes	No	No	9	8
92	1x51	2x51	leukotriene_off	2.44	0	No	No	No	No	3	7
93	5x32	5x35	leukotriene_off	2.44	0	No	No	No	No	4	2
94	7x51	7x55	leukotriene_off	2.43583	0	No	No	No	Yes	6	7
95	5x44	5x48	leukotriene_off	2.3875	0	No	No	No	No	6	4
96	7x45	Na1	leukotriene_off	2.37625	0	No	No	No	No	9	0
97	7x29	7x33	leukotriene_off	2.33875	0	No	No	No	No	1	5
98	2x65	2x66	leukotriene_off	2.315	0	No	No	No	No	5	3
99	1x43	1x44	leukotriene_off	2.23333	0	Yes	No	No	No	5	5
100	5x58	5x62	leukotriene_off	2.21667	0	Yes	Yes	No	No	9	5
101	5x37	6x59	leukotriene_off	2.19542	0	No	No	No	No	3	4
102	7x54	8x51	leukotriene_off	2.18917	0	No	No	No	No	7	0
103	6x36	CT	leukotriene_off	2.1725	0	No	No	Yes	No	7	0
104	3x48	5x57	leukotriene_off	2.16125	0	No	No	No	No	6	6
105	3x48	3x52	leukotriene_off	2.1575	0	No	No	No	No	6	6
106	6x47	7x40	leukotriene_off	2.13	0	Yes	No	No	No	7	7
107	1x58	I1x51	leukotriene_off	2.125	0	No	No	No	No	2	6
108	7x28	7x32	leukotriene_off	2.115	0	No	No	No	No	3	3
109	6x31	6x35	leukotriene_off	2.02833	0	Yes	No	No	No	4	6
110	7x28	E3	leukotriene_off	2.005	0	No	No	Yes	Yes	3	2
111	4x40	4x44	leukotriene_off	1.99583	0	No	No	No	No	4	3
112	3x27	3x31	leukotriene_off	1.92917	0	No	No	No	No	4	5
113	6x28	6x31	leukotriene_off	1.92875	0	No	No	Yes	No	0	4
114	1x25	1x28	leukotriene_off	1.91708	0	No	No	No	No	0	0
115	5x40	5x41	leukotriene_off	1.905	0	Yes	No	No	No	5	4
116	CT	I1x48	leukotriene_off	1.9	0	Yes	No	No	No	0	5
117	4x38	4x40	leukotriene_off	1.895	0	No	No	No	No	5	4
118	3x46	7x52	leukotriene_off	1.87417	0	No	No	No	Yes	8	7
119	3x53	I2x53	leukotriene_off	1.86875	0	No	No	No	No	7	6
120	1x56	8x50	leukotriene_off	1.8575	0	Yes	No	No	No	6	0
121	6x35	6x38	leukotriene_off	1.84875	0	No	No	No	No	6	4
122	7x53	7x54	leukotriene_off	1.805	0	Yes	Yes	No	No	9	7
123	7x23	7x26	leukotriene_off	1.78125	0	No	No	No	No	0	1
124	2x37	8x48	leukotriene_off	1.76417	0	No	No	No	No	7	0
125	1x56	7x53	leukotriene_off	1.735	0	Yes	No	Yes	Yes	6	9
126	5x29	E2	leukotriene_off	1.71875	0	No	No	Yes	Yes	0	3
127	5x58	6x42	leukotriene_off	1.7	0	Yes	Yes	No	No	9	4
128	5x51	6x46	leukotriene_off	1.67083	0	Yes	Yes	No	No	6	5
129	6x37	7x56	leukotriene_off	1.65875	0	No	No	No	No	7	6
130	5x52	5x56	leukotriene_off	1.65667	0	No	No	No	No	4	4
131	1x23	7x24	leukotriene_off	1.5925	0	No	No	No	No	0	0
132	I2x54	I2x57	leukotriene_off	1.53625	0	No	No	No	No	4	7
133	6x60	6x61	leukotriene_off	1.51083	0	No	No	No	No	4	2
134	8x49	8x52	leukotriene_off	1.34583	0	No	No	No	No	0	0
135	5x38	5x42	leukotriene_off	1.34	0	No	No	No	No	3	3
136	2x39	8x47	leukotriene_off	1.3175	0	No	No	No	No	7	0
137	1x32	2x67	leukotriene_off	1.3	0	No	No	No	No	4	4
138	5x48	5x52	leukotriene_off	1.23167	0	No	No	No	No	4	4
139	6x64	E3	leukotriene_off	1.23125	0	No	No	Yes	Yes	2	2
140	6x461	7x40	leukotriene_off	1.18	0	No	No	No	No	0	7
141	I2x52	I2x55	leukotriene_off	1.1775	0	No	No	No	No	5	4
142	1x30	1x33	leukotriene_off	1.09583	0	Yes	No	No	No	4	4
143	2x48	2x52	leukotriene_off	1.085	0	No	No	No	No	5	7
144	5x62	5x66	leukotriene_off	1.07	0	No	No	No	No	5	4
145	4x55	4x56	leukotriene_off	1.0375	0	No	No	No	No	4	4
146	1x30	NT	leukotriene_off	0.99	0	Yes	No	No	No	4	5
147	5x34	6x63	leukotriene_off	0.91	0	No	No	No	No	1	3
148	7x24	E3	leukotriene_off	0.855	0	No	No	Yes	Yes	0	2
149	7x23	E3	leukotriene_off	0.855	0	No	No	Yes	Yes	0	2
150	2x38	4x38	leukotriene_off	0.8275	0	No	No	No	No	5	5
151	4x59	4x63	leukotriene_off	0.7675	0	No	No	No	No	4	4
152	6x29	6x33	leukotriene_off	0.761667	0	No	No	No	No	0	7
153	4x51	4x55	leukotriene_off	0.73	0	No	No	No	No	4	4
154	4x39	I1x50	leukotriene_off	0.7175	0	No	No	No	No	4	6
155	4x47	4x50	leukotriene_off	0.7025	0	No	No	Yes	No	3	9
156	2x51	2x55	leukotriene_off	0.6925	0	No	No	No	No	7	5
157	1x47	2x55	leukotriene_off	0.6925	0	No	No	No	No	5	5
158	5x67	I3	leukotriene_off	0.6925	0	No	No	Yes	Yes	5	4
159	1x24	1x26	leukotriene_off	0.685	0	No	No	No	No	0	0
160	5x31	E2	leukotriene_off	0.65	0	No	No	Yes	Yes	0	3
161	1x56	8x54	leukotriene_off	0.620833	0	Yes	No	No	No	6	0
162	4x44	4x48	leukotriene_off	0.6125	0	No	No	No	No	3	3
163	6x32	CT	leukotriene_off	0.585	0	No	No	Yes	No	7	0
164	1x59	8x57	leukotriene_off	0.505833	0	No	No	No	No	4	0
165	6x64	6x65	leukotriene_off	0.4875	0	No	No	No	No	2	0
166	7x56	7x57	leukotriene_off	0.4875	0	No	No	No	No	6	0
167	1x40	1x41	leukotriene_off	0.405	0	No	No	No	No	4	5
168	1x29	1x32	leukotriene_off	0.4025	0	No	No	No	No	4	4
169	5x55	5x59	leukotriene_off	0.38	0	No	No	No	No	4	3
170	1x20	1x24	leukotriene_off	0.34875	0	No	No	No	No	0	0
171	8x54	8x58	leukotriene_off	0.345833	0	No	No	No	No	0	0
172	I2x51	I2x55	leukotriene_off	0.31	0	No	No	No	No	5	4
173	8x55	8x58	leukotriene_off	0.235	0	No	No	No	No	0	0
174	1x35	2x64	Shared	11.8279	3.15	No	No	No	Yes	5	5
175	1x39	2x61	Shared	3.88583	5.54	Yes	No	No	No	7	7
176	1x39	7x42	Shared	5.705	4.87	Yes	No	No	No	7	6
177	1x42	7x47	Shared	3.78458	1.71	No	No	No	No	7	7
178	1x43	2x57	Shared	3.62833	4.73	Yes	No	No	No	5	7
179	1x45	7x47	Shared	4.46	6.46	No	No	No	No	6	7
180	1x50	2x50	Shared	7.19333	12.12	Yes	Yes	Yes	Yes	9	9
181	1x50	7x50	Shared	8.41667	8.15	Yes	Yes	No	No	9	9
182	1x55	1x59	Shared	8.21833	4.64	No	No	No	No	4	4
183	1x57	2x40	Shared	3.7525	3.25	No	Yes	No	No	6	7
184	1x57	2x43	Shared	4.005	3.07	No	Yes	No	Yes	6	8
185	1x57	2x44	Shared	6.44042	7.14	No	Yes	No	No	6	6
186	2x38	I2x57	Shared	6.43583	11.77	No	No	No	No	5	7
187	2x42	3x46	Shared	5.08958	5.78	No	No	No	No	7	8
188	2x45	4x46	Shared	10.3821	8.24	No	No	No	No	9	7
189	2x45	4x50	Shared	6.59167	4.52	No	No	Yes	No	9	9
190	2x46	3x42	Shared	5.37417	2.77	No	Yes	Yes	No	9	7
191	2x46	7x49	Shared	6.59667	6.87	No	Yes	No	No	9	9
192	2x49	4x50	Shared	3.81167	2.59	No	No	Yes	No	8	9
193	2x50	7x46	Shared	6.5375	5.89	Yes	Yes	No	No	9	9
194	2x50	7x49	Shared	7.00333	6.73	Yes	Yes	No	No	9	9
195	2x53	3x35	Shared	9.61	4.85	No	No	No	No	6	8
196	2x56	3x31	Shared	3.74833	3.17	No	No	No	No	6	5
197	2x59	E1x52	Shared	9.00625	7.5	No	No	Yes	Yes	6	7
198	2x60	Lig	Shared	8.53875	18.93	Yes	No	Yes	Yes	6	0
199	2x62	2x66	Shared	15.1221	14.84	No	No	No	No	4	3
200	2x62	E1x51	Shared	4.48792	5.58	No	No	No	No	4	3
201	2x62	E1x52	Shared	7.90625	6.79	No	No	Yes	Yes	4	7
202	2x63	E1x50	Shared	8.43917	5.01	No	No	Yes	Yes	5	8
203	E1x49	E2	Shared	8.14125	4.61	No	No	Yes	Yes	4	3
204	E1x50	E1x52	Shared	18.4154	5.01	Yes	Yes	Yes	Yes	8	7
205	3x25	E1x50	Shared	8.65125	9.14	No	No	Yes	Yes	9	8
206	E1x50	E2x50	Shared	7.34667	15.67	Yes	Yes	No	No	8	9
207	E1x51	E1x52	Shared	5.55458	2.64	No	No	Yes	Yes	3	7
208	3x22	3x26	Shared	8.77333	17.01	No	No	No	No	3	7
209	3x22	E2	Shared	6.28042	5.96	No	No	Yes	Yes	3	3
210	3x25	E2x50	Shared	7.28	7.28	No	No	No	No	9	9
211	3x29	4x65	Shared	11.285	14.67	No	Yes	No	No	5	4
212	3x30	3x34	Shared	6.94	3.79	No	No	Yes	Yes	4	5
213	3x30	4x62	Shared	14.8004	10.55	No	No	No	No	4	4
214	3x34	4x54	Shared	3.6575	6.55	Yes	Yes	No	No	5	3
215	3x36	6x48	Shared	7.09458	3.49	No	No	Yes	Yes	7	9
216	3x37	4x56	Shared	4.69	10.55	Yes	Yes	No	No	7	4
217	3x37	5x46	Shared	4.0575	3.75	Yes	Yes	No	Yes	7	4
218	3x38	4x50	Shared	4.31417	5.19	No	No	Yes	No	7	9
219	3x38	4x53	Shared	4.5375	3.42	No	No	No	No	7	7
220	3x40	5x50	Shared	5.23	3.53	No	No	Yes	Yes	7	9
221	3x42	4x49	Shared	8.02708	4.28	Yes	No	No	No	7	7
222	3x44	5x50	Shared	5.24583	5.25	No	No	Yes	Yes	7	9
223	3x44	5x53	Shared	4.205	4.56	No	No	No	No	7	6
224	3x47	5x54	Shared	6.075	8.08	No	No	No	No	9	8
225	3x47	5x58	Shared	5.8275	3.82	No	No	Yes	Yes	9	9
226	3x49	I2x57	Shared	7.10125	8.34	No	No	No	No	8	7
227	3x50	5x58	Shared	4.3725	7.2	Yes	No	Yes	Yes	9	9
228	3x51	5x57	Shared	4.01333	6.52	Yes	No	No	No	8	6
229	3x51	5x61	Shared	4.59	3.1	Yes	No	No	No	8	8
230	4x60	5x39	Shared	4.34792	3.05	No	No	No	Yes	8	4
231	4x64	E2	Shared	7.6025	18.27	No	No	Yes	Yes	4	3
232	4x65	E2x52	Shared	6.4125	15.85	No	No	No	No	4	5
233	E2	E2	Shared	43.1754	35.95	Yes	Yes	Yes	Yes	3	3
234	E2	E2x52	Shared	7.99667	8.34	Yes	Yes	No	No	3	5
235	5x36	E2	Shared	9.88083	13.38	No	No	Yes	Yes	3	3
236	5x39	E2	Shared	3.81	11.98	No	Yes	Yes	Yes	4	3
237	5x35	E2	Shared	5.9925	5.67	No	No	Yes	Yes	2	3
238	5x33	6x62	Shared	4.5	1.51	No	No	No	No	1	3
239	5x40	6x55	Shared	8.93125	2.75	Yes	No	Yes	No	5	5
240	5x42	5x46	Shared	5.9725	7.78	No	No	No	Yes	3	4
241	5x43	6x55	Shared	6.3925	2.63	No	No	Yes	No	5	5
242	5x44	6x56	Shared	3.97292	3.15	No	No	No	No	6	5
243	5x47	5x51	Shared	7.905	6.43	No	Yes	Yes	Yes	8	6
244	5x47	6x49	Shared	5.16375	3.65	No	Yes	No	No	8	5
245	5x47	6x52	Shared	14.2554	9.05	No	Yes	Yes	Yes	8	8
246	5x49	5x50	Shared	3.95	1.64	No	No	Yes	Yes	5	9
247	5x51	5x55	Shared	4.92583	3.93	Yes	Yes	No	No	6	4
248	I3	I3	Shared	5.88	4.28	Yes	Yes	Yes	Yes	4	4
249	6x40	7x52	Shared	3.68208	5.71	No	No	No	Yes	7	7
250	6x44	6x48	Shared	11.3592	5.01	No	No	Yes	Yes	9	9
251	6x47	7x45	Shared	4.95292	5.28	Yes	No	No	No	7	9
252	6x48	7x45	Shared	7.02667	7.41	Yes	Yes	No	No	9	9
253	6x48	Lig	Shared	5.61	3.54	Yes	Yes	Yes	Yes	9	0
254	6x50	7x37	Shared	3.925	3.28	No	No	No	No	9	7
255	6x51	6x52	Shared	8.48292	5.44	No	Yes	Yes	Yes	6	8
256	6x51	6x55	Shared	13.5325	15.12	No	Yes	Yes	No	6	5
257	6x51	7x38	Shared	5.3575	4.84	No	Yes	No	No	6	5
258	6x58	7x34	Shared	8.44792	3.49	No	Yes	No	No	4	4
259	6x61	7x27	Shared	4.49292	3	No	No	No	No	2	2
260	E3	E3	Shared	4.03417	7.14	Yes	Yes	Yes	Yes	2	2
261	7x35	Lig	Shared	4.48667	6.83	No	No	Yes	Yes	3	0
262	7x38	Lig	Shared	7.84542	6.21	No	No	Yes	Yes	5	0
263	7x42	Lig	Shared	5.48	3.03	No	No	Yes	Yes	6	0
264	3x41	5x50	Shared	7.29667	6.76	No	No	Yes	Yes	6	9
265	4x39	4x43	Shared	4.47125	3.71	No	No	No	No	4	4
266	5x51	6x45	Shared	5.20292	2.77	Yes	Yes	No	No	6	5
267	6x54	7x37	Shared	5.0725	2.98	No	No	No	No	4	7
268	6x58	7x31	Shared	4.68083	1.44	No	Yes	No	No	4	4
269	3x33	Lig	Shared	9.28167	2.13	No	No	Yes	Yes	4	0
270	3x37	Lig	Shared	4.5625	4.37	Yes	Yes	Yes	Yes	7	0
271	4x61	Lig	Shared	3.67	2.78	No	No	Yes	Yes	4	0
272	5x60	5x64	Shared	3.5725	13.1	No	No	No	Yes	4	5
273	1x32	2x64	Shared	3.5375	1.5	No	No	No	Yes	4	5
274	6x57	7x30	Shared	3.52667	3.15	No	No	No	No	5	4
275	4x59	4x60	Shared	3.5225	3.5	No	No	No	No	4	8
276	6x39	7x52	Shared	3.515	1.38	No	No	No	Yes	5	7
277	5x40	6x59	Shared	3.48875	3.15	Yes	No	No	No	5	4
278	1x42	7x43	Shared	3.485	3.15	No	No	No	No	7	5
279	6x54	7x34	Shared	3.31833	2.62	No	No	No	No	4	4
280	6x58	7x30	Shared	3.29417	3.98	No	Yes	No	No	4	4
281	2x50	3x39	Shared	3.20583	2.94	Yes	Yes	No	No	9	9
282	5x33	5x36	Shared	3.0975	5.82	No	No	No	No	1	3
283	1x38	7x39	Shared	3.04333	3.15	No	No	No	No	5	4
284	4x38	4x41	Shared	2.93875	1.51	No	No	No	No	5	4
285	3x34	4x57	Shared	2.8875	3.39	Yes	Yes	No	No	5	6
286	4x52	4x56	Shared	2.80125	6.92	No	No	No	No	4	4
287	3x56	I2x52	Shared	2.76	2.62	No	No	No	No	5	5
288	1x50	2x51	Shared	2.7475	5.49	Yes	Yes	No	No	9	7
289	3x34	4x53	Shared	2.65083	4.85	Yes	Yes	No	No	5	7
290	6x49	6x53	Shared	2.575	2.98	No	No	No	No	5	6
291	1x47	1x48	Shared	2.5625	3.28	No	No	No	No	5	5
292	5x37	6x63	Shared	2.55625	4.73	No	No	No	No	3	3
293	6x48	7x41	Shared	2.38583	5.19	Yes	Yes	No	No	9	7
294	4x45	4x49	Shared	2.36042	1.54	No	No	No	No	5	7
295	6x47	7x48	Shared	2.18125	2.62	Yes	No	No	No	7	7
296	2x41	I1x51	Shared	2.125	2.43	No	No	No	No	7	6
297	3x48	5x53	Shared	1.9825	4.28	No	No	No	No	6	6
298	1x46	7x47	Shared	1.8825	3.71	No	No	No	No	8	7
299	3x52	I2x53	Shared	1.875	3	No	No	No	No	6	6
300	I2x52	I2x56	Shared	1.7825	1.49	No	No	No	No	5	4
301	3x21	E1x50	Shared	1.69917	2.81	No	No	Yes	Yes	8	8
302	1x52	1x56	Shared	1.60042	7.93	No	No	Yes	No	6	6
303	1x31	7x36	Shared	1.535	4.61	No	No	No	No	3	5
304	5x60	5x63	Shared	1.29083	4.76	No	No	No	No	4	3
305	3x56	I2x50	Shared	1.1125	1.44	No	No	No	No	5	8
306	1x37	1x41	Shared	0.99	1.54	No	No	No	No	4	5
307	7x57	7x58	Shared	0.5275	2.11	No	No	No	Yes	0	0
308	7x58	7x59	Shared	0.5275	2.11	No	Yes	No	No	0	0
309	1x29	1x30	leukotriene_on	0	8.16	No	No	Yes	No	4	4
310	1x31	7x32	leukotriene_on	0	2.85	No	No	No	No	3	3
311	1x33	1x37	leukotriene_on	0	2.85	No	No	No	No	4	4
312	1x34	7x36	leukotriene_on	0	4.47	No	No	No	No	5	5
313	1x36	2x64	leukotriene_on	0	2.85	No	No	No	Yes	6	5
314	1x39	7x39	leukotriene_on	0	3.15	Yes	No	No	No	7	4
315	1x52	7x55	leukotriene_on	0	4.29	No	No	No	Yes	6	7
316	1x52	7x62	leukotriene_on	0	3.21	No	No	No	Yes	6	0
317	1x53	2x47	leukotriene_on	0	3.39	No	No	No	No	8	8
318	1x53	7x55	leukotriene_on	0	2.62	No	No	No	Yes	8	7
319	1x55	1x60	leukotriene_on	0	6	No	No	No	No	4	5
320	1x56	1x60	leukotriene_on	0	2.64	Yes	No	No	No	6	5
321	1x56	7x62	leukotriene_on	0	5.27	Yes	No	No	Yes	6	0
322	1x57	7x62	leukotriene_on	0	6.26	No	Yes	No	Yes	6	0
323	1x58	2x44	leukotriene_on	0	4.15	No	No	No	No	2	6
324	I1x49	I1x50	leukotriene_on	0	4.07	No	No	No	No	6	6
325	2x39	I2x57	leukotriene_on	0	3.88	No	No	No	No	7	7
326	2x43	7x61	leukotriene_on	0	4.47	No	Yes	No	No	8	0
327	2x46	3x43	leukotriene_on	0	4.28	No	Yes	No	No	9	8
328	2x46	3x46	leukotriene_on	0	5.65	No	Yes	No	No	9	8
329	2x46	7x53	leukotriene_on	0	3.52	No	Yes	Yes	Yes	9	9
330	2x50	7x50	leukotriene_on	0	3.22	Yes	Yes	No	No	9	9
331	2x52	3x35	leukotriene_on	0	3.42	No	No	No	No	7	8
332	2x53	7x42	leukotriene_on	0	2.62	No	No	No	No	6	6
333	2x53	7x46	leukotriene_on	0	6.46	No	No	No	No	6	9
334	2x56	3x32	leukotriene_on	0	6.76	No	No	No	No	6	6
335	2x59	3x28	leukotriene_on	0	5.59	No	No	No	No	6	4
336	2x60	3x29	leukotriene_on	0	6.79	Yes	No	No	Yes	6	5
337	2x64	Lig	leukotriene_on	0	11.18	No	Yes	Yes	Yes	5	0
338	3x25	3x29	leukotriene_on	0	4.42	No	No	No	Yes	9	5
339	3x29	4x61	leukotriene_on	0	4.15	No	Yes	No	No	5	4
340	3x30	4x57	leukotriene_on	0	2.67	No	No	No	No	4	6
341	3x36	Lig	leukotriene_on	0	5.27	No	No	Yes	Yes	7	0
342	3x37	4x53	leukotriene_on	0	2.54	Yes	Yes	No	No	7	7
343	3x41	3x44	leukotriene_on	0	3.64	No	No	No	No	6	7
344	3x43	7x53	leukotriene_on	0	6.04	No	No	Yes	Yes	8	9
345	3x46	7x53	leukotriene_on	0	3.59	No	No	Yes	Yes	8	9
346	3x47	5x57	leukotriene_on	0	3.26	No	No	No	No	9	6
347	3x50	7x53	leukotriene_on	0	8.23	Yes	No	Yes	Yes	9	9
348	3x55	5x64	leukotriene_on	0	2.77	No	No	No	Yes	7	5
349	I2x51	I2x54	leukotriene_on	0	3.51	No	No	No	No	5	4
350	4x56	5x46	leukotriene_on	0	2.95	No	No	No	Yes	4	4
351	4x64	5x35	leukotriene_on	0	6.53	No	No	No	No	4	2
352	4x64	5x39	leukotriene_on	0	4.36	No	No	No	Yes	4	4
353	4x65	E2x51	leukotriene_on	0	4.28	No	No	No	No	4	3
354	E2	E2x50	leukotriene_on	0	3.42	Yes	Yes	No	No	3	9
355	E2	E2x51	leukotriene_on	0	8.99	Yes	Yes	No	No	3	3
356	E2x51	E2x52	leukotriene_on	0	4.33	No	No	No	No	3	5
357	5x36	E3	leukotriene_on	0	4.15	No	No	Yes	Yes	3	2
358	5x39	5x43	leukotriene_on	0	7.39	No	Yes	No	No	4	5
359	5x40	6x58	leukotriene_on	0	2.65	Yes	No	No	Yes	5	4
360	5x43	Lig	leukotriene_on	0	8.24	No	No	Yes	Yes	5	0
361	5x45	5x46	leukotriene_on	0	3.17	No	No	No	Yes	4	4
362	5x47	6x44	leukotriene_on	0	4.29	No	Yes	No	No	8	9
363	5x51	6x44	leukotriene_on	0	5.36	Yes	Yes	No	No	6	9
364	5x55	6x41	leukotriene_on	0	3.07	No	No	No	No	4	7
365	5x58	6x37	leukotriene_on	0	8.83	Yes	Yes	No	No	9	7
366	5x58	6x40	leukotriene_on	0	3.63	Yes	Yes	No	No	9	7
367	5x61	5x62	leukotriene_on	0	3.53	No	No	No	No	8	5
368	5x61	5x65	leukotriene_on	0	2.85	No	No	No	No	8	8
369	5x63	5x64	leukotriene_on	0	6.4	No	No	No	Yes	3	5
370	5x66	I3	leukotriene_on	0	3.5	No	No	Yes	Yes	4	4
371	5x68	I3	leukotriene_on	0	6.41	No	No	Yes	Yes	5	4
372	6x31	6x32	leukotriene_on	0	21.32	Yes	No	No	No	4	7
373	6x31	6x33	leukotriene_on	0	2.59	Yes	No	No	No	4	7
374	6x32	7x58	leukotriene_on	0	4.5	No	No	No	Yes	7	0
375	6x36	7x56	leukotriene_on	0	3.15	No	No	No	No	7	6
376	6x38	6x42	leukotriene_on	0	2.98	No	No	No	No	4	4
377	6x40	7x53	leukotriene_on	0	4.84	No	No	Yes	Yes	7	9
378	6x43	6x47	leukotriene_on	0	2.59	No	No	Yes	No	6	7
379	6x43	7x52	leukotriene_on	0	2.95	No	No	No	Yes	6	7
380	6x48	6x52	leukotriene_on	0	3.17	Yes	Yes	Yes	Yes	9	8
381	6x49	6x50	leukotriene_on	0	3.28	No	No	No	No	5	9
382	6x51	7x34	leukotriene_on	0	6.17	No	Yes	No	No	6	4
383	6x54	6x58	leukotriene_on	0	2.85	No	No	No	Yes	4	4
384	6x61	E3	leukotriene_on	0	14.02	No	No	Yes	Yes	2	2
385	6x61	7x26	leukotriene_on	0	7.85	No	No	No	No	2	1
386	7x55	7x62	leukotriene_on	0	5.34	No	Yes	No	Yes	7	0
387	7x55	I4	leukotriene_on	0	2.62	No	Yes	No	No	7	0
388	7x60	7x63	leukotriene_on	0	6.01	No	No	No	No	0	0
389	7x61	7x62	leukotriene_on	0	6.07	No	No	No	Yes	0	0
390	5x47	5x48	leukotriene_on	0	2.44	No	Yes	No	No	8	4
391	5x65	I3	leukotriene_on	0	2.43	No	No	Yes	Yes	8	4
392	6x32	6x35	leukotriene_on	0	2.13	No	No	No	No	7	6
393	1x48	1x49	leukotriene_on	0	2.03	No	No	No	No	5	7
394	3x32	3x33	leukotriene_on	0	1.96	No	No	No	No	6	4
395	3x23	3x24	leukotriene_on	0	1.95	No	No	No	No	3	5
396	4x47	4x48	leukotriene_on	0	1.95	No	No	No	No	3	3
397	7x64	I4	leukotriene_on	0	1.95	No	No	No	No	0	0
398	3x37	3x41	leukotriene_on	0	1.93	Yes	Yes	No	No	7	6
399	2x57	2x58	leukotriene_on	0	1.87	No	No	No	No	7	9
400	5x32	5x34	leukotriene_on	0	1.86	No	No	No	No	4	1
401	7x57	7x63	leukotriene_on	0	1.86	No	No	No	No	0	0
402	4x48	4x51	leukotriene_on	0	1.84	No	No	No	No	3	4
403	1x53	7x50	leukotriene_on	0	1.77	No	No	No	No	8	9
404	1x46	2x54	leukotriene_on	0	1.71	No	No	No	No	8	5
405	6x36	7x58	leukotriene_on	0	1.71	No	No	No	Yes	7	0
406	1x46	1x50	leukotriene_on	0	1.7	No	No	Yes	Yes	8	9
407	1x54	2x47	leukotriene_on	0	1.7	No	No	No	No	7	8
408	2x43	7x54	leukotriene_on	0	1.7	No	Yes	No	No	8	7
409	3x45	4x49	leukotriene_on	0	1.62	No	No	No	No	6	7
410	5x41	6x59	leukotriene_on	0	1.62	No	No	No	No	4	4
411	2x40	I1x48	leukotriene_on	0	1.61	No	No	No	No	7	5
412	1x41	1x45	leukotriene_on	0	1.6	No	No	No	No	5	6
413	2x39	2x43	leukotriene_on	0	1.59	No	No	No	Yes	7	8
414	5x461	6x52	leukotriene_on	0	1.59	No	No	Yes	Yes	6	8
415	2x57	2x61	leukotriene_on	0	1.58	No	No	No	No	7	7
416	1x36	1x40	leukotriene_on	0	1.55	No	No	No	No	6	4
417	4x38	4x39	leukotriene_on	0	1.5	No	No	No	No	5	4
418	1x38	7x36	leukotriene_on	0	1.49	No	No	No	No	5	5
419	1x54	2x48	leukotriene_on	0	1.49	No	No	No	No	7	5
420	5x44	6x52	leukotriene_on	0	1.46	No	No	Yes	Yes	6	8
421	I2x50	I2x51	leukotriene_on	0	1.44	No	No	No	No	8	5
422	5x32	5x33	leukotriene_on	0	1.44	No	No	No	No	4	1
423	2x41	4x39	leukotriene_on	0	1.41	No	No	No	No	7	4
424	I2x55	I2x56	leukotriene_on	0	1.41	No	No	No	No	4	4
425	4x41	I2x56	leukotriene_on	0	1.41	No	No	No	No	4	4
426	1x38	7x40	leukotriene_on	0	1.38	No	No	No	No	5	7
427	1x47	2x51	leukotriene_on	0	1.38	No	No	No	No	5	7
428	2x40	I1x51	leukotriene_on	0	1.38	No	No	No	No	7	6
429	2x41	4x46	leukotriene_on	0	1.38	No	No	No	No	7	7
430	6x36	7x52	leukotriene_on	0	1.38	No	No	No	Yes	7	7
431	7x40	7x43	leukotriene_on	0	1.38	No	No	No	No	7	5
432	3x54	5x64	leukotriene_on	0	1.31	No	No	No	Yes	8	5
433	7x25	7x29	leukotriene_on	0	1.21	No	No	No	No	0	1

Orange: nodes, hubs and links specific of leukotriene_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of leukotriene_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	leukotriene_off Avg Int. Strength	leukotriene_on Avg Int. Strength	leukotriene_off Num Of Links	leukotriene_on Num Of Links	ConSurf
1	1x30	leukotriene_off	3.049	8.16	5	1	4
2	1x39	leukotriene_off	5.09917	4.52	5	3	7
3	1x43	leukotriene_off	4.13271	4.73	4	1	5
4	1x56	leukotriene_off	1.45344	5.28	4	3	6
5	2x60	leukotriene_off	7.20052	12.86	4	2	6
6	3x42	leukotriene_off	6.03115	3.525	4	2	7
7	3x50	leukotriene_off	3.32192	7.715	5	2	9
8	3x51	leukotriene_off	4.92104	4.81	4	2	8
9	4x50	leukotriene_off	4.036	4.1	5	3	9
10	5x40	leukotriene_off	4.59406	2.85	4	3	5
11	6x31	leukotriene_off	3.29844	11.955	4	2	4
12	6x47	leukotriene_off	3.20479	3.49667	4	3	7
13	6x55	leukotriene_off	7.73646	6.83333	6	3	5
14	CT	leukotriene_off	5.56278	0	9	0	0
15	I1	leukotriene_off	3.5551	0	4	0	0
16	1x50	Shared	5.20802	6.865	4	4	9
17	2x50	Shared	5.985	6.18	4	5	9
18	E1x50	Shared	7.39798	7.528	7	5	8
19	E1x52	Shared	10.2206	5.485	4	4	7
20	3x34	Shared	4.03396	4.645	4	4	5
21	3x37	Shared	4.17625	4.628	5	5	7
22	E2	Shared	11.938	13.8655	12	11	3
23	5x50	Shared	5.43062	4.295	4	4	9
24	5x51	Shared	4.92615	4.6225	4	4	6
25	5x58	Shared	4.90451	5.87	6	4	9
26	I3	Shared	4.51187	4.18	4	5	4
27	6x48	Shared	6.42768	4.635	7	6	9
28	6x52	Shared	7.64448	4.142	4	5	8
29	E3	Shared	2.1691	8.1125	6	4	2
30	7x53	Shared	3.69725	5.244	5	5	9
31	Lig	Shared	5.98375	6.59182	14	11	0
32	1x57	leukotriene_on	4.73264	4.93	3	4	6
33	2x43	leukotriene_on	4.75187	2.7075	2	4	8
34	2x46	leukotriene_on	5.98542	4.618	2	5	9
35	2x64	leukotriene_on	6.99722	4.67	3	4	5
36	3x29	leukotriene_on	9.68104	7.5075	2	4	5
37	5x39	leukotriene_on	3.98111	6.695	3	4	4
38	5x46	leukotriene_on	5.015	4.4125	2	4	4
39	5x47	leukotriene_on	9.10806	5.172	3	5	8
40	5x64	leukotriene_on	3.5725	5.895	1	4	5
41	6x51	leukotriene_on	9.1243	7.8925	3	4	6
42	6x58	leukotriene_on	5.47431	2.882	3	5	4
43	7x52	leukotriene_on	3.02375	2.855	3	4	7
44	7x55	leukotriene_on	2.66062	3.7175	2	4	7
45	7x58	leukotriene_on	0.5275	2.6075	2	4	0
46	7x62	leukotriene_on	3.27	5.23	1	5	0

Orange: nodes, hubs and links specific of leukotriene_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of leukotriene_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	leukotriene_off Recurrence	leukotriene_on Recurrence	leukotriene_off Hub1?	leukotriene_on Hub1?	leukotriene_off Hub2?	leukotriene_on Hub2?	ConSurf1	ConSurf2
1	1x30	7x35	leukotriene_off	23.4168	0	Yes	No	No	No	4	3
2	1x35	7x35	leukotriene_off	11.4659	0	No	No	No	No	5	3
3	1x35	2x64	leukotriene_off	15.8529	2.18171	No	No	No	Yes	5	5
4	1x35	1x39	leukotriene_off	10.0906	0	No	No	Yes	No	5	7
5	7x35	Lig	leukotriene_off	25.9062	2.17175	No	No	Yes	Yes	3	0
6	1x39	2x57	leukotriene_off	38.7154	0	Yes	No	No	No	7	7
7	1x43	2x57	leukotriene_off	36.6738	2.73959	Yes	No	No	No	5	7
8	1x43	1x47	leukotriene_off	30.9328	0	Yes	No	No	No	5	5
9	1x47	2x55	leukotriene_off	27.1055	0	No	No	No	No	5	5
10	2x51	2x55	leukotriene_off	25.5757	0	No	No	No	No	7	5
11	3x40	6x48	leukotriene_off	100	0	No	No	Yes	Yes	7	9
12	3x40	5x50	leukotriene_off	99.7974	2.46065	No	No	Yes	Yes	7	9
13	3x41	5x50	leukotriene_off	62.2335	7.25244	No	No	Yes	Yes	6	9
14	3x41	4x49	leukotriene_off	61.29	0	No	No	No	No	6	7
15	3x42	4x49	leukotriene_off	59.4456	8.41801	Yes	No	No	No	7	7
16	7x49	7x53	leukotriene_off	49.0672	0	No	No	Yes	Yes	9	9
17	1x56	7x53	leukotriene_off	14.8774	0	Yes	No	Yes	Yes	6	9
18	2x43	7x53	leukotriene_off	27.2815	0	No	Yes	Yes	Yes	8	9
19	3x44	5x50	leukotriene_off	80.661	0.0796971	No	No	Yes	Yes	7	9
20	3x44	5x54	leukotriene_off	61.5299	0	No	No	No	No	7	8
21	3x47	5x54	leukotriene_off	60.4371	3.54652	No	No	No	No	9	8
22	3x50	6x37	leukotriene_off	27.6812	0	Yes	No	No	No	9	7
23	3x46	6x37	leukotriene_off	21.9989	0	No	No	No	No	8	7
24	2x42	3x46	leukotriene_off	16.4606	2.61008	No	No	No	No	7	8
25	2x42	3x49	leukotriene_off	13.3955	0	No	No	No	No	7	8
26	3x49	I2x57	leukotriene_off	11.8443	4.69217	No	No	No	No	8	7
27	2x40	I1	leukotriene_off	16.194	0	No	No	Yes	No	7	0
28	4x39	I1	leukotriene_off	10.9488	0	No	No	Yes	No	4	0
29	3x42	4x50	leukotriene_off	15.3465	0	Yes	No	Yes	No	7	9
30	2x63	2x64	leukotriene_off	10.565	0	No	No	No	Yes	5	5
31	2x60	E2x51	leukotriene_off	31.2633	0	Yes	No	No	No	6	3
32	E2x50	E2x51	leukotriene_off	30.2719	0	No	No	No	No	9	3
33	E2	Lig	leukotriene_off	22.5426	0	Yes	Yes	Yes	Yes	3	0
34	3x44	5x53	leukotriene_off	27.7878	4.91134	No	No	No	No	7	6
35	3x48	5x53	leukotriene_off	26.3539	2.46065	No	No	No	No	6	6
36	3x48	5x57	leukotriene_off	20.9382	0	No	No	No	No	6	6
37	6x55	Lig	leukotriene_off	45.5757	0	Yes	No	Yes	Yes	5	0
38	5x40	6x56	leukotriene_off	10.2612	0	Yes	No	No	No	5	5
39	5x58	6x38	leukotriene_off	11.7324	0	Yes	Yes	No	No	9	4
40	6x55	7x34	leukotriene_off	22.8998	0	Yes	No	No	No	5	4
41	6x58	7x34	leukotriene_off	13.1343	7.30225	No	Yes	No	No	4	4
42	1x30	7x32	leukotriene_off	15.613	0	Yes	No	No	No	4	3
43	7x28	7x32	leukotriene_off	14.1738	0	No	No	No	No	3	3
44	3x51	3x55	leukotriene_off	10.3038	0	Yes	No	No	No	8	7
45	6x35	6x38	leukotriene_off	10.2772	0	No	No	No	No	6	4
46	2x39	3x50	leukotriene_off	12.0629	0	No	No	Yes	No	7	9
47	1x39	2x60	leukotriene_off	23.0757	0	Yes	No	Yes	No	7	6
48	E1x50	E2x50	leukotriene_off	27.1482	3.21777	Yes	Yes	No	No	8	9
49	1x39	2x61	Shared	10.6343	10.8687	Yes	No	No	No	7	7
50	6x48	Lig	Shared	99.4403	75.3138	Yes	Yes	Yes	Yes	9	0
51	6x48	7x45	Shared	18.5181	51.6637	Yes	Yes	No	No	9	9
52	6x47	7x45	Shared	15.8209	49.9402	Yes	No	No	No	7	9
53	1x50	2x51	Shared	24.0512	10.4702	Yes	Yes	No	No	9	7
54	1x50	2x50	Shared	21.3646	24.5567	Yes	Yes	Yes	Yes	9	9
55	2x46	3x42	Shared	46.903	11.1875	No	Yes	Yes	No	9	7
56	2x46	7x49	Shared	45.9009	48.6651	No	Yes	No	No	9	9
57	1x57	2x43	Shared	25.677	15.0229	No	Yes	No	Yes	6	8
58	1x57	2x40	Shared	17.8678	15.9494	No	Yes	No	No	6	7
59	3x47	5x58	Shared	59.3337	34.2399	No	No	Yes	Yes	9	9
60	3x50	5x58	Shared	42.484	12.0442	Yes	No	Yes	Yes	9	9
61	E1x50	E1x52	Shared	20.2505	25.0946	Yes	Yes	Yes	Yes	8	7
62	2x60	Lig	Shared	41.5885	29.8267	Yes	No	Yes	Yes	6	0
63	3x38	4x50	Shared	10.9275	32.4965	No	No	Yes	No	7	9
64	3x37	Lig	Shared	17.3827	65.4413	Yes	Yes	Yes	Yes	7	0
65	3x51	5x57	Shared	19.451	24.0486	Yes	No	No	No	8	6
66	5x40	6x55	Shared	20.1439	15.1624	Yes	No	Yes	No	5	5
67	7x42	Lig	Shared	17.3348	100	No	No	Yes	Yes	6	0
68	1x39	7x42	Shared	16.6898	31.8589	Yes	No	No	No	7	6
69	2x50	7x49	Shared	21.2154	50.259	Yes	Yes	No	No	9	9
70	1x38	7x36	leukotriene_on	0	11.9247	No	No	No	No	5	5
71	1x45	7x47	leukotriene_on	1.66844	10.4702	No	No	No	No	6	7
72	1x38	7x39	leukotriene_on	1.57249	17.2544	No	No	No	No	5	4
73	1x39	7x39	leukotriene_on	0	19.7051	Yes	No	No	No	7	4
74	2x64	Lig	leukotriene_on	0	11.7653	No	Yes	Yes	Yes	5	0
75	1x46	7x47	leukotriene_on	1.66844	17.4836	No	No	No	No	8	7
76	1x46	1x50	leukotriene_on	0	22.2056	No	No	Yes	Yes	8	9
77	2x53	7x42	leukotriene_on	0	85.266	No	No	No	No	6	6
78	2x53	7x46	leukotriene_on	0	83.1739	No	No	No	No	6	9
79	2x50	7x46	leukotriene_on	4.78145	82.8352	Yes	Yes	No	No	9	9
80	2x50	7x50	leukotriene_on	0	68.7886	Yes	Yes	No	No	9	9
81	1x53	7x50	leukotriene_on	0	76.3001	No	No	No	No	8	9
82	1x53	7x55	leukotriene_on	0	69.4361	No	No	No	Yes	8	7
83	1x52	7x55	leukotriene_on	0	10.9384	No	No	No	Yes	6	7
84	7x55	7x62	leukotriene_on	0	53.6661	No	Yes	No	Yes	7	0
85	1x56	7x62	leukotriene_on	0	10.3806	Yes	No	No	Yes	6	0
86	1x56	1x60	leukotriene_on	0	14.4252	Yes	No	No	No	6	5
87	1x57	7x62	leukotriene_on	0	30.8528	No	Yes	No	Yes	6	0
88	7x61	7x62	leukotriene_on	0	14.8237	No	No	No	Yes	0	0
89	2x43	7x61	leukotriene_on	0	12.5922	No	Yes	No	No	8	0
90	2x39	2x43	leukotriene_on	0	17.9817	No	No	No	Yes	7	8
91	2x39	I2x57	leukotriene_on	0	13.3293	No	No	No	No	7	7
92	3x37	4x53	leukotriene_on	0	44.1423	Yes	Yes	No	No	7	7
93	3x38	4x53	leukotriene_on	9.39765	34.1602	No	No	No	No	7	7
94	2x45	4x50	leukotriene_on	0.101279	29.2688	No	No	Yes	No	9	9
95	2x45	4x46	leukotriene_on	1.58849	27.7645	No	No	No	No	9	7
96	2x46	7x53	leukotriene_on	0	35.8538	No	Yes	Yes	Yes	9	9
97	2x60	3x29	leukotriene_on	0	28.4021	Yes	No	No	Yes	6	5
98	3x25	3x29	leukotriene_on	0	41.7613	No	No	No	Yes	9	5
99	3x25	E1x50	leukotriene_on	0.234542	34.1502	No	No	Yes	Yes	9	8
100	4x61	Lig	leukotriene_on	1.23667	30.0458	No	No	Yes	Yes	4	0
101	3x29	4x61	leukotriene_on	0	28.7308	No	Yes	No	No	5	4
102	5x43	Lig	leukotriene_on	0	52.6898	No	No	Yes	Yes	5	0
103	5x39	5x43	leukotriene_on	0	45.9255	No	Yes	No	No	4	5
104	5x39	E2	leukotriene_on	0.250533	36.581	No	Yes	Yes	Yes	4	3
105	3x29	4x65	leukotriene_on	1.22601	12.0542	No	Yes	No	No	5	4
106	3x34	4x53	leukotriene_on	7.85714	12.0442	Yes	Yes	No	No	5	7
107	3x37	3x41	leukotriene_on	0	16.8659	Yes	Yes	No	No	7	6
108	3x50	7x53	leukotriene_on	0	13.5087	Yes	No	Yes	Yes	9	9
109	6x40	7x53	leukotriene_on	0	26.7185	No	No	Yes	Yes	7	9
110	5x58	6x40	leukotriene_on	0	30.8428	Yes	Yes	No	No	9	7
111	6x43	6x47	leukotriene_on	0	47.4098	No	No	Yes	No	6	7
112	6x43	7x52	leukotriene_on	0	46.6328	No	No	No	Yes	6	7
113	6x40	7x52	leukotriene_on	1.62047	36.571	No	No	No	Yes	7	7
114	3x47	5x57	leukotriene_on	0	27.4656	No	No	No	No	9	6
115	3x51	5x61	leukotriene_on	3.23561	20.6117	Yes	No	No	No	8	8
116	2x41	4x46	leukotriene_on	0	26.589	No	No	No	No	7	7
117	2x41	4x39	leukotriene_on	0	25.9813	No	No	No	No	7	4
118	4x38	4x39	leukotriene_on	0	21.6776	No	No	No	No	5	4
119	4x38	4x41	leukotriene_on	1.62047	19.3066	No	No	No	No	5	4
120	4x41	I2x56	leukotriene_on	0	16.9157	No	No	No	No	4	4
121	I2x52	I2x56	leukotriene_on	1.19403	12.4427	No	No	No	No	5	4
122	5x36	E2	leukotriene_on	5.09595	21.6079	No	No	Yes	Yes	3	3
123	5x43	6x55	leukotriene_on	1.73241	19.0875	No	No	Yes	No	5	5
124	7x38	Lig	leukotriene_on	2.94243	13.409	No	No	Yes	Yes	5	0
125	6x51	7x38	leukotriene_on	1.63113	11.4365	No	Yes	No	No	6	5
126	6x51	7x34	leukotriene_on	0	14.2658	No	Yes	No	No	6	4
127	6x48	6x52	leukotriene_on	0	24.7759	Yes	Yes	Yes	Yes	9	8
128	6x44	6x48	leukotriene_on	1.66844	22.7336	No	No	Yes	Yes	9	9
129	5x47	6x44	leukotriene_on	0	11.6557	No	Yes	No	No	8	9
130	5x47	6x52	leukotriene_on	5.17591	14.0167	No	Yes	Yes	Yes	8	8
131	5x47	6x49	leukotriene_on	4.4936	15.4015	No	Yes	No	No	8	5
132	5x61	5x65	leukotriene_on	0	13.678	No	No	No	No	8	8
133	5x65	I3	leukotriene_on	0	10.1614	No	No	Yes	Yes	8	4
134	6x36	7x52	leukotriene_on	0	26.4893	No	No	No	Yes	7	7
135	6x36	7x58	leukotriene_on	0	21.9865	No	No	No	Yes	7	0
136	6x32	7x58	leukotriene_on	0	10.1016	No	No	No	Yes	7	0
137	2x41	I1x51	leukotriene_on	3.08635	17.1847	No	No	No	No	7	6
138	2x40	I1x51	leukotriene_on	0	16.587	No	No	No	No	7	6

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
1x35	2x64	Shared	11.8279	3.15	0	0	2	1
1x39	2x60	leukotriene_off	5.755	0	0	0	2	1
1x39	7x42	Shared	5.705	4.87	0	0	2	1
2x53	3x35	Shared	9.61	4.85	0	0	1	2
2x53	Lig	leukotriene_off	4.3	0	0	0	1	0
2x60	3x32	leukotriene_off	4.88625	0	1	0	1	1
2x60	Lig	Shared	8.53875	18.93	1	0	1	0
E1x49	E2	Shared	8.14125	4.61	0	0	2	1
3x22	E2	Shared	6.28042	5.96	1	1	2	1
3x25	E2x50	Shared	7.28	7.28	2	1	2	2
3x29	4x65	Shared	11.285	14.67	0	0	1	2
3x29	Lig	leukotriene_off	8.07708	0	0	0	1	0
3x32	Lig	leukotriene_off	4.24	0	1	0	1	0
3x36	6x48	Shared	7.09458	3.49	0	2	1	1
3x37	4x56	Shared	4.69	10.55	0	2	1	2
3x37	5x46	Shared	4.0575	3.75	0	2	1	2
3x37	5x461	leukotriene_off	3.625	0	0	2	1	2
4x60	5x39	Shared	4.34792	3.05	0	0	2	1
4x64	E2	Shared	7.6025	18.27	0	1	2	1
4x65	E2x52	Shared	6.4125	15.85	0	1	2	2
E2	E2	Shared	43.1754	35.95	1	1	1	1
E2	E2x52	Shared	7.99667	8.34	1	1	1	2
5x36	E2	Shared	9.88083	13.38	1	1	2	1
5x39	E2	Shared	3.81	11.98	1	1	1	1
5x35	E2	Shared	5.9925	5.67	1	1	2	1
5x40	6x55	Shared	8.93125	2.75	0	0	2	1
5x43	6x55	Shared	6.3925	2.63	0	0	1	1
6x44	6x48	Shared	11.3592	5.01	0	2	2	1
6x48	7x45	Shared	7.02667	7.41	0	2	1	2
6x48	Lig	Shared	5.61	3.54	0	2	1	0
6x51	6x52	Shared	8.48292	5.44	1	0	2	2
6x51	6x55	Shared	13.5325	15.12	1	0	2	1
6x51	7x38	Shared	5.3575	4.84	1	0	2	1
6x55	7x34	leukotriene_off	4.60667	0	1	0	1	2
7x35	Lig	Shared	4.48667	6.83	0	0	1	0
7x38	Lig	Shared	7.84542	6.21	0	0	1	0
7x42	Lig	Shared	5.48	3.03	0	0	1	0
6x52	6x55	leukotriene_off	3.89333	0	1	0	2	1
3x33	Lig	Shared	9.28167	2.13	1	0	1	0
3x37	Lig	Shared	4.5625	4.37	0	2	1	0
4x61	Lig	Shared	3.67	2.78	1	0	1	0
E2	Lig	leukotriene_off	4.8325	0	1	1	1	0
5x39	Lig	leukotriene_off	3.78542	0	1	1	1	0
6x55	Lig	leukotriene_off	9.0625	0	1	0	1	0
1x35	1x39	leukotriene_off	7.0175	0	0	0	2	2
1x35	7x35	leukotriene_off	6.5525	0	0	0	2	1
2x60	E2x51	leukotriene_off	9.62208	0	1	0	1	2
2x63	2x64	leukotriene_off	5.62625	0	0	0	2	1
3x33	4x61	leukotriene_off	5.04125	0	1	0	1	1
3x37	6x52	leukotriene_off	3.94625	0	0	2	1	2
3x40	6x48	leukotriene_off	7.27458	0	0	0	2	1
E2x50	E2x51	leukotriene_off	4.85625	0	2	1	2	2
6x45	6x48	leukotriene_off	4.24292	0	0	0	2	1
1x32	2x64	Shared	3.5375	1.5	0	0	2	1
1x30	7x35	leukotriene_off	2.56667	0	0	0	2	1
6x48	7x41	Shared	2.38583	5.19	0	2	1	2
5x29	E2	leukotriene_off	1.71875	0	0	0	2	1
5x31	E2	leukotriene_off	0.65	0	0	0	2	1
1x36	2x64	leukotriene_on	0	2.85	0	0	2	1
2x53	7x42	leukotriene_on	0	2.62	0	0	1	1
2x53	7x46	leukotriene_on	0	6.46	0	0	1	2
2x56	3x32	leukotriene_on	0	6.76	0	0	2	1
2x60	3x29	leukotriene_on	0	6.79	1	0	1	1
2x64	Lig	leukotriene_on	0	11.18	0	0	1	0
3x25	3x29	leukotriene_on	0	4.42	2	1	2	1
3x29	4x61	leukotriene_on	0	4.15	0	0	1	1
3x36	Lig	leukotriene_on	0	5.27	0	2	1	0
3x37	4x53	leukotriene_on	0	2.54	0	2	1	2
4x56	5x46	leukotriene_on	0	2.95	0	2	2	2
4x64	5x35	leukotriene_on	0	6.53	0	1	2	2
4x64	5x39	leukotriene_on	0	4.36	0	1	2	1
4x65	E2x51	leukotriene_on	0	4.28	0	1	2	2
E2	E2x50	leukotriene_on	0	3.42	1	1	1	2
E2	E2x51	leukotriene_on	0	8.99	1	1	1	2
E2x51	E2x52	leukotriene_on	0	4.33	0	1	2	2
5x39	5x43	leukotriene_on	0	7.39	1	1	1	1
5x43	Lig	leukotriene_on	0	8.24	0	0	1	0
6x48	6x52	leukotriene_on	0	3.17	0	2	1	2
6x51	7x34	leukotriene_on	0	6.17	1	0	2	2
3x32	3x33	leukotriene_on	0	1.96	1	0	1	1
3x37	3x41	leukotriene_on	0	1.93	0	2	1	2
5x461	6x52	leukotriene_on	0	1.59	0	0	2	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	leukotriene_off	blt_off cyslt_off
	leukotriene_on	blt_on

Network Difference
Value	leukotriene_off	leukotriene_on
I_min	3.59625	2.54
Number of Linked Nodes	288	236
Number of Specific Nodes	57 (19.79%)	5 (2.12%)
Number of Shared Nodes	231 (80.21%)	231 (97.88%)
Number of Links	308	260
Number of Specific Links	173 (56.17%)	125 (48.08%)
Number of Shared Links	135 (43.83%)	135 (51.92%)
Number of Hubs	31	31
Number of Specific Hubs	15 (48.39%)	15 (48.39%)
Number of Shared Hubs	16 (51.61%)	16 (51.61%)
Average % Shared Neighbours (Jaccard)	29.99
Average % Shared Neighbours (Otsuka)	38.43
Average % Shared Neighbours (Overlap Coefficient)	46.95
Average % Shared Cliques (k3-6)	77.00
Graphlets Similarity	0.51713

Paths Difference
Value	leukotriene_off	leukotriene_on
Number Of Nodes in MetaPath	67	85
Specific Nodes in MetaPath	29 (43.28%)	47 (55.29%)
Shared Nodes in MetaPath	231 (80.21%)	231 (80.21%)
Number Of Links MetaPath	69	90
Specific Links in MetaPath	48 (69.57%)	69 (76.67%)
Shared Links in MetaPath	135 (43.83%)	135 (43.83%)
Number of Shortest Paths	44675	31498
Length Of Smallest Path	3	3
Average Path Length	12.7308	11.4841
Length of Longest Path	31	30
Minimum Path Strength	0.6925	1.38
Average Path Strength	5.11069	4.86325
Maximum Path Strength	13.8146	15.825
Minimum Path Correlation	0.700417	0.7
Average Path Correlation	0.910376	0.920745
Maximum Path Correlation	0.987917	0.99
Minimum % Of Corr. Nodes	4	4.34783
Average % Of Corr. Nodes	44.4777	53.4113
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	38.0155	36.4988
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

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