Orange: nodes, hubs and links specific of leukotriene_on_gp network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of leukotriene_off network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.


Index Hub Owner leukotriene_on_gp Avg Int. Strength leukotriene_off Avg Int. Strength leukotriene_on_gp Num Of Links leukotriene_off Num Of Links ConSurf
11x57 leukotriene_on_gp4.934.73264437
2I1x49 leukotriene_on_gp8.6150406
32x46 leukotriene_on_gp4.6185.98542529
42x64 leukotriene_on_gp4.676.99722433
53x29 leukotriene_on_gp7.50759.68104426
6I2x51 leukotriene_on_gp4.92250.31415
7I2x57 leukotriene_on_gp7.04255.02444437
85x39 leukotriene_on_gp6.6953.98111435
95x46 leukotriene_on_gp4.41255.015425
105x47 leukotriene_on_gp5.1729.10806538
115x64 leukotriene_on_gp5.8953.5725415
126x44 leukotriene_on_gp4.292511.3592419
136x51 leukotriene_on_gp7.89259.1243436
146x58 leukotriene_on_gp2.8825.47431533
157x42 leukotriene_on_gp3.25755.5925426
167x55 leukotriene_on_gp3.71752.66062427
177x58 leukotriene_on_gp2.60750.5275424
187x62 leukotriene_on_gp5.233.27516
19G.HN.43 leukotriene_on_gp3.56250409
20G.S1.02 leukotriene_on_gp5.03250405
21G.H1.01 leukotriene_on_gp2.983330609
22G.H1.10 leukotriene_on_gp4.2550408
23G.S3.02 leukotriene_on_gp5.73750404
24G.S3.04 leukotriene_on_gp9.9350406
25G.S3.05 leukotriene_on_gp3.610507
26G.S3.06 leukotriene_on_gp8.15250405
27G.S3.08 leukotriene_on_gp5.51750409
28G.h2s4.01 leukotriene_on_gp4.3260509
29G.S4.04 leukotriene_on_gp5.73250409
30G.S4.05 leukotriene_on_gp3.520407
31G.s4h3.03 leukotriene_on_gp6.1850408
32G.s4h3.04 leukotriene_on_gp6.88750408
33G.s4h3.05 leukotriene_on_gp5.9860509
34G.H3.09 leukotriene_on_gp5.4320509
35G.H3.13 leukotriene_on_gp4.0260505
36G.H3.17 leukotriene_on_gp8.620405
37G.H3.18 leukotriene_on_gp5.330409
38G.S5.04 leukotriene_on_gp3.62250409
39G.S5.05 leukotriene_on_gp3.546670609
40G.HG.04 leukotriene_on_gp4.121670609
41G.HG.15 leukotriene_on_gp4.730407
42G.hgh4.01 leukotriene_on_gp4.210406
43G.hgh4.02 leukotriene_on_gp4.286670607
44G.H4.03 leukotriene_on_gp5.22750404
45G.H4.11 leukotriene_on_gp3.03750407
46G.H4.15 leukotriene_on_gp3.1650408
47G.h4s6.02 leukotriene_on_gp4.3450408
48G.S6.02 leukotriene_on_gp6.690507
49G.S6.04 leukotriene_on_gp6.990409
50G.H5.08 leukotriene_on_gp4.0950408
51G.H5.23 leukotriene_on_gp4.09750404
52b.lhb1x6 leukotriene_on_gp3.9180503
53b.b1x6 leukotriene_on_gp6.10409
54b.l1x3 leukotriene_on_gp8.0940509
55b.b2x5 leukotriene_on_gp7.2280507
56b.b3x6 leukotriene_on_gp6.54750409
57b.l3x2 leukotriene_on_gp4.790509
58b.b4x6 leukotriene_on_gp9.640409
59b.l4x2 leukotriene_on_gp9.92750404
60b.b5x3 leukotriene_on_gp6.8180509
61b.b5x5 leukotriene_on_gp3.90250405
62b.l5x1 leukotriene_on_gp4.17250408
63b.l5x5 leukotriene_on_gp6.312860709
64b.b6x5 leukotriene_on_gp3.53250406
65b.l6x5 leukotriene_on_gp5.5050404
66b.b7x1 leukotriene_on_gp5.85250404
67b.l7x2 leukotriene_on_gp4.68750409
68b.b8x4 leukotriene_on_gp4.7820506
69b.b9x4 leukotriene_on_gp5.54750409
70b.l9x3 leukotriene_on_gp5.305710709
71b.l9x6 leukotriene_on_gp4.5840508
72b.b10x5 leukotriene_on_gp4.0050609
73b.l10x1 leukotriene_on_gp3.9450403
74b.l11x2 leukotriene_on_gp6.9180509
75b.b12x6 leukotriene_on_gp8.026670608
76b.l12x1 leukotriene_on_gp3.40750406
77b.b13x3 leukotriene_on_gp6.08750404
78b.b13x7 leukotriene_on_gp5.6940507
79b.l13x3 leukotriene_on_gp6.474290709
80b.l13x6 leukotriene_on_gp4.2920509
81b.b14x3 leukotriene_on_gp3.59750405
82b.b15x1 leukotriene_on_gp5.0540509
83b.b15x3 leukotriene_on_gp3.9850409
84b.l15x2 leukotriene_on_gp5.0550409
85b.b16x4 leukotriene_on_gp9.2150406
86b.b16x5 leukotriene_on_gp3.47250405
87b.b16x6 leukotriene_on_gp7.0820508
88b.b17x7 leukotriene_on_gp6.760408
89b.l17x3 leukotriene_on_gp8.480509
90b.l17x6 leukotriene_on_gp5.4060509
91b.b18x3 leukotriene_on_gp4.0150408
92b.b18x5 leukotriene_on_gp4.28750405
93b.l18x1 leukotriene_on_gp5.551430706
94b.b19x2 leukotriene_on_gp5.410506
95b.b19x4 leukotriene_on_gp4.40408
96b.l19x2 leukotriene_on_gp7.1360509
97b.b20x3 leukotriene_on_gp2.6160508
98b.b20x4 leukotriene_on_gp8.6880508
99b.b20x6 leukotriene_on_gp5.671670606
100b.b20x7 leukotriene_on_gp2.81750409
101b.l20x2 leukotriene_on_gp5.74750409
102b.b21x7 leukotriene_on_gp4.2240505
103b.b22x5 leukotriene_on_gp3.4920507
104b.l22x5 leukotriene_on_gp6.470409
105b.b23x6 leukotriene_on_gp4.8880507
106b.b24x5 leukotriene_on_gp3.06750405
107b.b24x7 leukotriene_on_gp5.82250409
108b.b25x3 leukotriene_on_gp4.1650405
109b.b25x7 leukotriene_on_gp5.7750407
110b.l25x3 leukotriene_on_gp9.10750409
111b.l26x3 leukotriene_on_gp6.26250407
112b.b27x3 leukotriene_on_gp3.92750408
113b.l27x1 leukotriene_on_gp12.3460509
114b.l27x2 leukotriene_on_gp7.2060509
115b.b28x4 leukotriene_on_gp4.92750406
116b.b28x6 leukotriene_on_gp6.5480509
117g.h1x13 leukotriene_on_gp3.4850409
118g.l1x6 leukotriene_on_gp4.79250408
119g.h2x13 leukotriene_on_gp4.66750406
120g.ctx5 leukotriene_on_gp4.8650609
121g.ctx8 leukotriene_on_gp3.2880506
122g.ctx17 leukotriene_on_gp5.6350409
123g.ctx18 leukotriene_on_gp5.1350608
1241x50 Shared6.8655.20802449
1252x50 Shared6.185.985549
126E1x50 Shared7.5287.39798578
127E1x52 Shared5.48510.2206447
1283x34 Shared4.6454.03396445
1293x37 Shared4.6284.17625557
1303x50 Shared7.02753.32192459
131E2 Shared13.865511.93811123
1325x50 Shared4.2955.43062449
1335x51 Shared4.24.92615546
1345x58 Shared5.24.90451568
135I3 Shared5.328754.51187844
1366x48 Shared4.6356.42768679
1376x52 Shared4.1427.64448548
138E3 Shared8.11252.1691463
1397x53 Shared5.2443.69725559
140Lig Shared6.591825.9837511140
1411x30 leukotriene_off8.163.049153
1421x39 leukotriene_off4.525.09917357
1431x43 leukotriene_off4.734.13271146
1441x56 leukotriene_off5.281.45344347
1452x60 leukotriene_off12.867.20052246
1463x42 leukotriene_off3.5256.03115247
1473x51 leukotriene_off4.814.92104248
1484x50 leukotriene_off4.14.036359
1495x40 leukotriene_off2.854.59406344
1506x31 leukotriene_off13.673.29844345
1516x47 leukotriene_off3.496673.20479347
1526x55 leukotriene_off6.833337.73646366
153CT leukotriene_off05.56278090
154I1 leukotriene_off03.5551040
   
Orange: nodes, hubs and links specific of leukotriene_on_gp network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of leukotriene_off network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Owner leukotriene_on_gp Recurrence leukotriene_off Recurrence leukotriene_on_gp Hub1? leukotriene_off Hub1? leukotriene_on_gp Hub2? leukotriene_off Hub2? ConSurf1 ConSurf2
12x50 7x50 leukotriene_on_gp10.24980YesYesNoNo99
26x44 6x48 leukotriene_on_gp45.65621.66844YesNoYesYes99
33x43 6x44 leukotriene_on_gp55.42090NoNoYesNo89
43x43 7x53 leukotriene_on_gp55.72550NoNoYesYes89
53x50 7x53 leukotriene_on_gp38.36860YesYesYesYes99
63x47 5x57 leukotriene_on_gp80.04660NoNoNoNo96
73x51 5x61 leukotriene_on_gp80.38683.23561NoYesNoNo88
85x61 5x65 leukotriene_on_gp80.72680NoNoNoNo88
95x65 I3 leukotriene_on_gp81.91520NoNoYesYes84
10G.S6.02 I3 leukotriene_on_gp88.73380YesNoYesYes74
11G.H5.10 G.S6.02 leukotriene_on_gp94.37840NoNoYesNo67
12G.H5.10 G.S5.03 leukotriene_on_gp94.54450NoNoNoNo68
13G.S5.03 G.S5.05 leukotriene_on_gp47.47220NoNoYesNo89
14G.S5.05 G.S6.04 leukotriene_on_gp51.14820YesNoYesNo99
15G.S6.04 G.s6h5.05 leukotriene_on_gp98.71340YesNoNoNo99
16G.s6h5.02 G.s6h5.05 leukotriene_on_gp98.90090NoNoNoNo79
17G.HG.01 G.s6h5.02 leukotriene_on_gp99.08790NoNoNoNo57
18G.H4.03 G.HG.01 leukotriene_on_gp99.27450YesNoNoNo45
19G.H4.03 G.HG.04 leukotriene_on_gp66.55370YesNoYesNo49
20G.HG.04 G.s4h3.01 leukotriene_on_gp33.47440YesNoNoNo97
21G.S5.06 G.s4h3.01 leukotriene_on_gp33.48170NoNoNoNo87
22G.S5.04 G.S5.06 leukotriene_on_gp66.25110YesNoNoNo98
23G.S4.04 G.S5.04 leukotriene_on_gp65.7610YesNoYesNo99
24G.H3.08 G.S4.04 leukotriene_on_gp1000NoNoYesNo99
25G.H2.04 G.H3.08 leukotriene_on_gp99.94590NoNoNoNo99
26G.H2.04 G.H2.07 leukotriene_on_gp99.83950NoNoNoNo99
27G.H2.07 G.S3.08 leukotriene_on_gp99.78540NoNoYesNo99
28G.S2.01 G.S3.08 leukotriene_on_gp47.46450NoNoYesNo99
29G.S2.01 b.l5x5 leukotriene_on_gp36.78970NoNoYesNo99
30b.l3x1 b.l5x5 leukotriene_on_gp72.29320NoNoYesNo99
31b.b2x1 b.l3x1 leukotriene_on_gp72.13260NoNoNoNo89
32b.b2x1 b.l27x1 leukotriene_on_gp71.63120NoNoYesNo89
33b.l25x6 b.l27x1 leukotriene_on_gp70.80680NoNoYesNo89
34b.l23x1 b.l25x6 leukotriene_on_gp70.6470NoNoNoNo68
35b.l21x7 b.l23x1 leukotriene_on_gp70.32770NoNoNoNo56
36b.b23x6 b.l21x7 leukotriene_on_gp70.00910YesNoNoNo75
37b.b23x6 b.b24x6 leukotriene_on_gp65.00410YesNoNoNo78
38b.b21x7 b.b24x6 leukotriene_on_gp64.84480YesNoNoNo58
39b.b21x5 b.b21x7 leukotriene_on_gp62.79590NoNoYesNo45
40b.b21x5 b.h2x1 leukotriene_on_gp62.63210NoNoNoNo45
41b.h2x1 b.h2x5 leukotriene_on_gp61.48370NoNoNoNo55
42b.h2x5 b.lhb1x3 leukotriene_on_gp61.31950NoNoNoNo52
43b.l22x5 b.lhb1x3 leukotriene_on_gp60.6620YesNoNoNo92
446x40 7x53 leukotriene_on_gp38.340NoNoYesYes79
455x58 6x40 leukotriene_on_gp39.59360YesYesNoNo87
46G.H5.06 G.S5.03 leukotriene_on_gp47.24030NoNoNoNo38
47G.H5.06 G.S6.04 leukotriene_on_gp47.31650NoNoYesNo39
48G.H4.03 G.H4.07 leukotriene_on_gp33.03730YesNoNoNo45
49G.H4.07 G.S6.05 leukotriene_on_gp33.03880NoNoNoNo54
50G.S5.06 G.S6.05 leukotriene_on_gp32.80120NoNoNoNo84
51G.H4.11 G.HG.04 leukotriene_on_gp33.59870YesNoYesNo79
52G.H4.11 G.H4.15 leukotriene_on_gp33.56490YesNoYesNo78
53G.H4.15 G.S4.06 leukotriene_on_gp33.83550YesNoNoNo87
54G.S4.04 G.S4.06 leukotriene_on_gp33.84320YesNoNoNo97
55G.S3.08 G.h2s4.01 leukotriene_on_gp38.20390YesNoYesNo99
56G.h2s4.01 b.l5x5 leukotriene_on_gp36.84710YesNoYesNo99
57b.l22x5 g.ctx8 leukotriene_on_gp51.87860YesNoYesNo96
58g.ctx5 g.ctx8 leukotriene_on_gp51.47640YesNoYesNo96
59g.ctx5 g.ctx6 leukotriene_on_gp51.10680YesNoNoNo97
60b.l26x5 g.ctx6 leukotriene_on_gp48.48550NoNoNoNo57
61b.l26x5 g.ctx17 leukotriene_on_gp46.94280NoNoYesNo59
62g.ctx17 g.ctx18 leukotriene_on_gp42.75220YesNoYesNo98
63b.b1x4 g.ctx18 leukotriene_on_gp41.81380NoNoYesNo78
64b.b1x4 b.b5x1 leukotriene_on_gp20.82160NoNoNoNo75
65b.b1x6 b.b5x1 leukotriene_on_gp20.64810YesNoNoNo95
66b.b1x6 b.b4x6 leukotriene_on_gp40.59590YesNoYesNo99
67b.b4x6 b.b5x3 leukotriene_on_gp31.79140YesNoYesNo99
68G.HN.43 b.b5x3 leukotriene_on_gp30.76170YesNoYesNo99
69G.HN.39 G.HN.43 leukotriene_on_gp29.02160NoNoYesNo59
70b.b1x4 b.b28x5 leukotriene_on_gp20.82160NoNoNoNo75
71b.b1x6 b.b28x5 leukotriene_on_gp20.64810YesNoNoNo95
72G.HN.39 b.b5x5 leukotriene_on_gp28.66960NoNoYesNo55
73G.S3.08 G.s3h2.03 leukotriene_on_gp14.09870YesNoNoNo99
74G.S2.01 b.l7x2 leukotriene_on_gp10.60650NoNoYesNo99
75G.s3h2.03 b.l7x2 leukotriene_on_gp11.0560NoNoYesNo99
76b.l7x2 b.l9x6 leukotriene_on_gp22.08740YesNoYesNo98
77G.H2.06 b.l9x6 leukotriene_on_gp12.32710NoNoYesNo98
78G.H2.06 b.l17x6 leukotriene_on_gp11.97540NoNoYesNo99
79b.l17x5 b.l17x6 leukotriene_on_gp11.54880NoNoYesNo69
80b.l17x5 b.l19x2 leukotriene_on_gp11.40330NoNoYesNo69
81b.b4x5 b.b5x5 leukotriene_on_gp13.80580NoNoYesNo75
82b.b3x3 b.b4x5 leukotriene_on_gp13.09960NoNoNoNo87
83b.b3x3 b.b4x3 leukotriene_on_gp12.74640NoNoNoNo87
84b.b4x3 b.l5x1 leukotriene_on_gp24.78620NoNoYesNo78
85b.b5x5 b.l8x8 leukotriene_on_gp14.15980YesNoNoNo54
86b.b5x7 b.l8x8 leukotriene_on_gp13.45370NoNoNoNo74
87b.b4x3 b.b5x7 leukotriene_on_gp12.74730NoNoNoNo77
88b.b8x4 b.l5x1 leukotriene_on_gp20.54060YesNoYesNo68
89b.b7x2 b.b8x4 leukotriene_on_gp17.00480NoNoYesNo86
90b.b6x5 b.b7x2 leukotriene_on_gp16.29680YesNoNoNo68
91b.b6x5 b.l6x4 leukotriene_on_gp13.46440YesNoNoNo65
92b.l6x3 b.l6x4 leukotriene_on_gp12.75620NoNoNoNo65
932x46 7x53 leukotriene_on_gp19.90740YesNoYesYes99
946x48 Lig Shared39.181299.4403YesYesYesYes90
953x50 5x58 Shared39.774442.484YesYesYesYes98
963x47 5x58 Shared79.695759.3337NoNoYesYes98
973x51 5x57 Shared80.216719.451NoYesNoNo86
982x50 7x49 Shared17.775521.2154YesYesNoNo99
992x46 7x49 Shared18.13745.9009YesNoNoNo99
1001x30 7x35 leukotriene_off023.4168NoYesNoNo34
1011x35 7x35 leukotriene_off011.4659NoNoNoNo54
1021x35 2x64 leukotriene_off0.36675815.8529NoNoYesNo53
1031x35 1x39 leukotriene_off010.0906NoNoNoYes57
1041x39 2x61 leukotriene_off1.4683410.6343NoYesNoNo77
1057x35 Lig leukotriene_off0.36675825.9062NoNoYesYes40
1066x48 7x45 leukotriene_off0.027246818.5181YesYesNoNo99
1076x47 7x45 leukotriene_off0.20213215.8209NoYesNoNo79
1081x39 2x57 leukotriene_off038.7154NoYesNoNo77
1091x43 2x57 leukotriene_off0.3671436.6738NoYesNoNo67
1101x43 1x47 leukotriene_off030.9328NoYesNoNo65
1111x47 2x55 leukotriene_off027.1055NoNoNoNo55
1122x51 2x55 leukotriene_off025.5757NoNoNoNo75
1131x50 2x51 leukotriene_off1.4679624.0512YesYesNoNo97
1141x50 2x50 leukotriene_off5.4773421.3646YesYesYesYes99
1153x40 6x48 leukotriene_off0100NoNoYesYes89
1163x40 5x50 leukotriene_off0.36675899.7974NoNoYesYes89
1173x41 5x50 leukotriene_off1.0999662.2335NoNoYesYes59
1183x41 4x49 leukotriene_off061.29NoNoNoNo56
1193x42 4x49 leukotriene_off1.1017559.4456NoYesNoNo76
1202x46 3x42 leukotriene_off1.4689246.903YesNoNoYes97
1217x49 7x53 leukotriene_off049.0672NoNoYesYes99
1221x56 7x53 leukotriene_off014.8774NoYesYesYes79
1232x43 7x53 leukotriene_off027.2815NoNoYesYes79
1241x57 2x43 leukotriene_off0.73408925.677YesNoNoNo77
1251x57 2x40 leukotriene_off0.73406517.8678YesNoNoNo77
1263x44 5x50 leukotriene_off0.00019087180.661NoNoYesYes79
1273x44 5x54 leukotriene_off061.5299NoNoNoNo78
1283x47 5x54 leukotriene_off0.18070760.4371NoNoNoNo98
1293x50 6x37 leukotriene_off027.6812YesYesNoNo97
1303x46 6x37 leukotriene_off021.9989NoNoNoNo87
1312x42 3x46 leukotriene_off0.37090916.4606NoNoNoNo78
1322x42 3x49 leukotriene_off013.3955NoNoNoNo78
1333x49 I2x57 leukotriene_off4.77177e-0511.8443NoNoYesNo87
1342x40 I1 leukotriene_off016.194NoNoNoYes70
1354x39 I1 leukotriene_off010.9488NoNoNoYes40
1363x42 4x50 leukotriene_off015.3465NoYesNoYes79
1372x63 2x64 leukotriene_off010.565NoNoYesNo53
138E1x50 E1x52 leukotriene_off4.3887620.2505YesYesYesYes87
1392x60 Lig leukotriene_off5.8447941.5885NoYesYesYes60
1402x60 E2x51 leukotriene_off031.2633NoYesNoNo63
141E2x50 E2x51 leukotriene_off030.2719NoNoNoNo93
142E2 Lig leukotriene_off022.5426YesYesYesYes30
1433x38 4x50 leukotriene_off1.4668210.9275NoNoNoYes69
1443x37 Lig leukotriene_off8.787317.3827YesYesYesYes70
1453x44 5x53 leukotriene_off0.73349227.7878NoNoNoNo76
1463x48 5x53 leukotriene_off0.36675826.3539NoNoNoNo66
1473x48 5x57 leukotriene_off020.9382NoNoNoNo66
1486x55 Lig leukotriene_off045.5757NoYesYesYes60
1495x40 6x55 leukotriene_off3.2856720.1439NoYesNoYes46
1505x40 6x56 leukotriene_off010.2612NoYesNoNo45
1515x58 6x38 leukotriene_off011.7324YesYesNoNo85
1526x55 7x34 leukotriene_off022.8998NoYesNoNo64
1536x58 7x34 leukotriene_off2.909313.1343YesNoNoNo34
1541x30 7x32 leukotriene_off015.613NoYesNoNo32
1557x28 7x32 leukotriene_off014.1738NoNoNoNo42
1563x51 3x55 leukotriene_off010.3038NoYesNoNo87
1576x35 6x38 leukotriene_off010.2772NoNoNoNo65
1582x39 3x50 leukotriene_off012.0629NoNoYesYes79
1597x42 Lig leukotriene_off4.8681317.3348YesNoYesYes60
1601x39 2x60 leukotriene_off023.0757NoYesNoYes76
1611x39 7x42 leukotriene_off4.4050316.6898NoYesYesNo76
162E1x50 E2x50 leukotriene_off0.007706427.1482YesYesNoNo89

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Midway



Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Node1Node2OwnerNet1LinkStrengthNet2LinkStrengthComm1Comm2Node1ShellNode2Shell
1x352x64Shared11.82793.150021
1x392x60leukotriene_off5.75500021
1x397x42Shared5.7054.870021
2x533x35Shared9.614.850012
2x53Ligleukotriene_off4.300010
2x603x32leukotriene_off4.8862501011
2x60LigShared8.5387518.931010
E1x49E2Shared8.141254.610021
3x22E2Shared6.280425.961221
3x25E2x50Shared7.287.282222
3x294x65Shared11.28514.670012
3x29Ligleukotriene_off8.0770800010
3x32Ligleukotriene_off4.2401010
3x366x48Shared7.094583.490111
3x374x56Shared4.6910.550112
3x375x46Shared4.05753.750112
3x375x461leukotriene_off3.62500112
4x605x39Shared4.347923.050021
4x64E2Shared7.602518.270221
4x65E2x52Shared6.412515.850222
E2E2Shared43.175435.951211
E2E2x52Shared7.996678.341212
5x36E2Shared9.8808313.381221
5x39E2Shared3.8111.981211
5x35E2Shared5.99255.671221
5x406x55Shared8.931252.750021
5x436x55Shared6.39252.630011
6x446x48Shared11.35925.010121
6x487x45Shared7.026677.410112
6x48LigShared5.613.540110
6x516x52Shared8.482925.441022
6x516x55Shared13.532515.121021
6x517x38Shared5.35754.841021
6x557x34leukotriene_off4.6066701012
7x35LigShared4.486676.830010
7x38LigShared7.845426.210110
7x42LigShared5.483.030110
6x526x55leukotriene_off3.8933301021
3x33LigShared9.281672.131010
3x37LigShared4.56254.370110
4x61LigShared3.672.781010
E2Ligleukotriene_off4.832501210
5x39Ligleukotriene_off3.7854201210
6x55Ligleukotriene_off9.062501010
1x351x39leukotriene_off7.017500022
1x357x35leukotriene_off6.552500021
2x60E2x51leukotriene_off9.6220801012
2x632x64leukotriene_off5.6262500021
3x334x61leukotriene_off5.0412501011
3x376x52leukotriene_off3.9462500112
3x406x48leukotriene_off7.2745800021
E2x50E2x51leukotriene_off4.8562502222
6x456x48leukotriene_off4.2429200021
1x322x64Shared3.53751.50021
1x307x35leukotriene_off2.5666700021
6x487x41Shared2.385835.190112
5x29E2leukotriene_off1.7187500021
5x31E2leukotriene_off0.6500021
1x362x64leukotriene_on_gp02.850021
2x537x42leukotriene_on_gp02.620011
2x537x46leukotriene_on_gp06.460012
2x563x32leukotriene_on_gp06.760021
2x603x29leukotriene_on_gp06.791011
2x64Ligleukotriene_on_gp011.180010
3x253x29leukotriene_on_gp04.422221
3x294x61leukotriene_on_gp04.150011
3x36Ligleukotriene_on_gp05.270110
3x374x53leukotriene_on_gp02.540112
4x565x46leukotriene_on_gp02.950122
4x645x35leukotriene_on_gp06.530222
4x645x39leukotriene_on_gp04.360221
4x65E2x51leukotriene_on_gp04.280222
E2E2x50leukotriene_on_gp03.421212
E2E2x51leukotriene_on_gp08.991212
E2x51E2x52leukotriene_on_gp04.330222
5x395x43leukotriene_on_gp07.391211
5x43Ligleukotriene_on_gp08.240010
6x486x52leukotriene_on_gp03.170112
6x517x34leukotriene_on_gp06.171022
7x387x42leukotriene_on_gp02.510111
3x323x33leukotriene_on_gp01.961011
3x373x41leukotriene_on_gp01.930112
5x4616x52leukotriene_on_gp01.590022

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
Id Description
leukotriene_on_gp blt_on_gp
leukotriene_off blt_off
cyslt_off
Network Difference
Value leukotriene_on_gp leukotriene_off
Imin 2.51 3.59625
Number of Linked Nodes 814 288
Number of Specific Nodes 582 (71.50%) 56  (19.44%)
Number of Shared Nodes 232 (28.50%) 232  (80.56%)
Number of Links 952 308
Number of Specific Links 817 (85.82%) 173  (56.17%)
Number of Shared Links 135 (14.18%) 135  (43.83%)
Number of Hubs 140 31
Number of Specific Hubs 123 (87.86%) 14  (45.16%)
Number of Shared Hubs 17 (12.14%) 17  (54.84%)
Average % Shared Neighbours (Jaccard) 9.99
Average % Shared Neighbours (Otsuka) 12.84
Average % Shared Neighbours (Overlap Coefficient) 15.66
Average % Shared Cliques (k3-6) 75.52
Graphlets Similarity 0.524735
Paths Difference
Value leukotriene_on_gp leukotriene_off
Number Of Nodes in MetaPath 92 67
Specific Nodes in MetaPath 81 (88.04%) 56  (83.58%)
Shared Nodes in MetaPath 232 (28.50%) 232  (28.50%)
Number Of Links MetaPath 99 69
Specific Links in MetaPath 93 (93.94%) 63  (91.30%)
Shared Links in MetaPath 135 (14.18%) 135  (14.18%)
Number of Shortest Paths 4596207 44675
Length Of Smallest Path 3 3
Average Path Length 50.8145 12.7308
Length of Longest Path 83 31
Minimum Path Strength 1.16 0.6925
Average Path Strength 5.35778 5.11069
Maximum Path Strength 21.84 13.8146
Minimum Path Correlation 0.7 0.700417
Average Path Correlation 0.99323 0.910376
Maximum Path Correlation 1 0.987917
Minimum % Of Corr. Nodes 1.72414 4
Average % Of Corr. Nodes 28.5546 44.4777
Maximum % Of Corr. Nodes 100 100
Minimum Path Hubs % 0 0
Average Path Hubs % 42.9649 38.0155
Maximum Path Hubs % 100 100

Details about the values in these tables can be found in the corresponding documentation page .

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download leukotriene_off_on_gp.zip<



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