Orange: nodes, hubs and links specific of lh_on_allo network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of lh_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.


Index Hub Owner lh_on_allo Avg Int. Strength lh_on Avg Int. Strength lh_on_allo Num Of Links lh_on Num Of Links ConSurf
1NT.L59 lh_on_allo4.93256.505427
2NT.?77 lh_on_allo5.82754.24415
3NT.N92 lh_on_allo4.9447.39333536
4NT.E102 lh_on_allo10.93518.78417
5NT.L111 lh_on_allo7.74756.54427
6NT.?117 lh_on_allo4.314.855523
7NT.L125 lh_on_allo4.8126.71667539
8NT.?126 lh_on_allo7.4129.78535
9NT.F138 lh_on_allo8.657.08333435
10NT.D157 lh_on_allo9.837513.3767436
11NT.V177 lh_on_allo5.53756.35413
12NT.L202 lh_on_allo6.787.36333437
13NT.?216 lh_on_allo5.526.045423
14NT.L259 lh_on_allo5.56256.965426
15NT.?280 lh_on_allo13.092515.11439
16NT.R283 lh_on_allo6.587510.44423
17NT.?331 lh_on_allo7.6956.96431
181x35 lh_on_allo7.849.74418
192x44 lh_on_allo5.7455.91333638
202x47 lh_on_allo7.30757.17333438
212x54 lh_on_allo6.528.23667439
223x38 lh_on_allo6.256.87333437
234x56 lh_on_allo5.14254.89333435
24E2.V505 lh_on_allo5.78753.28667435
255x51 lh_on_allo5.747.47333438
265x60 lh_on_allo5.474.00333434
276x35 lh_on_allo4.2644.40333537
287x46 lh_on_allo5.19759.015429
29Allo1 lh_on_allo7.5358301200
30NT.?58 Shared10.19512.955445
31NT.Q82 Shared9.687512.3725446
32NT.?113 Shared7.9210.3025541
33NT.I120 Shared4.7826.5425545
34NT.?127 Shared9.3413.914556
35NT.?131 Shared13.54511.124457
36NT.T133 Shared7.17757.9925448
37NT.I135 Shared6.13755.5425447
38NT.E154 Shared8.492510.6425447
39NT.?156 Shared13.553318.572657
40NT.N158 Shared9.3558.364459
41NT.?182 Shared12.823313.9057676
42NT.?183 Shared7.8358.7325447
43NT.N184 Shared9.066679.62714679
44NT.F186 Shared8.4933310.436658
45NT.?240 Shared12.807514.374452
46NT.?275 Shared17.27414.1733568
47NT.F282 Shared5.677.61458
48NT.E354 Shared6.3888.555547
491x32 Shared11.95813.685546
50I1.?389 Shared9.23814.59563
512x45 Shared9.12758.9025447
522x50 Shared6.95258.096459
532x52 Shared7.0566.9025547
542x56 Shared8.67.76556897
55E1.?426 Shared10.706712.2659
56E1.?427 Shared11.87514.275647
573x24 Shared9.6611.48448
583x25 Shared9.8516.014659
593x41 Shared8.8468.994558
603x56 Shared6.80257.45443
61E2.?508 Shared11.731210.7244898
62E2x50 Shared13.0210.3367469
63E2x51 Shared7.901676.65669
645x39 Shared7.50258.60143877
655x55 Shared6.7547.44667567
665x57 Shared9.2014310.0583766
675x58 Shared10.377812.4237989
685x61 Shared5.014295.45759
695x62 Shared6.9445.66167569
706x47 Shared5.70756.115469
717x41 Shared11.68758.61833467
727x47 Shared5.326.02459
737x49 Shared9.5557.845449
747x53 Shared6.8366.83833569
758x50 Shared7.876.215448
76Lig Shared211.107213.10122250
77NT.?62 lh_on4.976675.415344
78NT.I64 lh_on4.983335.78347
79NT.F94 lh_on7.103337.3075349
80NT.D95 lh_on8.918.05346
81NT.N107 lh_on9.4666711.965347
82NT.I114 lh_on5.716675.3925348
83NT.D140 lh_on5.596675.6175343
84NT.?143 lh_on11.0958.268254
85NT.F151 lh_on6.838.005345
86NT.?166 lh_on5.866.255244
87NT.N173 lh_on8.945.19144
88NT.?180 lh_on5.249.25245
89NT.F194 lh_on7.876678.635349
90NT.N195 lh_on9.6733311.495345
91NT.H209 lh_on5.616.7425141
92NT.F218 lh_on7.8410.085348
93NT.P224 lh_on8.836678.9925348
94NT.I229 lh_on7.324.38247
95NT.?241 lh_on11.363313.625347
96NT.?254 lh_on10.35339.29352
97NT.P260 lh_on7.376675.5275346
98NT.F265 lh_on8.387.6375347
99NT.?333 lh_on9.14513.3475241
100NT.?336 lh_on3.6159.388256
101NT.D355 lh_on7.117.845247
1021x36 lh_on10.1259.558259
1031x39 lh_on3.95.6375249
1041x49 lh_on6.393334.4975347
1051x50 lh_on9.928.6375349
1062x46 lh_on8.883336.664358
1072x64 lh_on11.12679.955349
108E1.W433 lh_on9.8714.39349
109I2.L478 lh_on2.282.4625344
1104x46 lh_on5.983338.12347
1114x50 lh_on6.546677.144355
1125x44 lh_on5.9353.32249
1136x30 lh_on6.083335.4175348
1148x53 lh_on7.369.6525148
   
Orange: nodes, hubs and links specific of lh_on_allo network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of lh_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Owner lh_on_allo Recurrence lh_on Recurrence lh_on_allo Hub1? lh_on Hub1? lh_on_allo Hub2? lh_on Hub2? ConSurf1 ConSurf2
1NT.?113 NT.I135 lh_on_allo10.95260YesYesYesYes17
2NT.?131 NT.N132 lh_on_allo13.0959.48824YesYesNoNo78
3Lig NT.N132 lh_on_allo13.49849.54008YesYesNoNo08
4NT.?131 NT.D157 lh_on_allo13.08949.20675YesYesYesNo76
5NT.I135 NT.L111 lh_on_allo11.79510YesYesYesNo77
6Lig NT.?126 lh_on_allo76.90590YesYesYesNo05
7NT.F151 NT.V177 lh_on_allo86.55890NoYesYesNo53
8NT.T197 NT.V177 lh_on_allo14.96790.578099NoNoYesNo53
9NT.?196 NT.T197 lh_on_allo14.53691.15584NoNoNoNo65
10NT.?196 NT.N195 lh_on_allo14.10541.71126NoNoNoYes65
11NT.N167 NT.N195 lh_on_allo12.80741.98231NoNoNoYes75
12Lig NT.?182 lh_on_allo14.32059.81473YesYesYesYes06
13NT.F169 NT.L179 lh_on_allo49.14690.590338NoNoNoNo68
14NT.L179 NT.V177 lh_on_allo97.91630NoNoYesNo83
15NT.F169 NT.F194 lh_on_allo49.37585.29432NoNoNoYes69
16NT.L179 NT.L199 lh_on_allo49.07361.52804NoNoNoNo88
17NT.F194 NT.L199 lh_on_allo49.1881.14144NoYesNoNo98
18NT.F194 NT.L202 lh_on_allo98.60281.19507NoYesYesNo97
19NT.L202 NT.P224 lh_on_allo98.93681.43049YesNoNoYes78
20NT.F218 NT.P224 lh_on_allo99.16513.0262NoYesNoYes88
21NT.P260 NT.T264 lh_on_allo99.66551.06009NoYesNoNo64
22NT.E243 NT.T264 lh_on_allo99.56140NoNoNoNo34
23NT.?241 NT.E243 lh_on_allo99.5391.22207NoYesNoNo73
247x30 Allo1 lh_on_allo55.48880NoNoYesNo80
257x30 NT.P352 lh_on_allo55.5830.37616NoNoNoNo89
26NT.E354 NT.P352 lh_on_allo55.67720YesYesNoNo79
277x34 NT.E354 lh_on_allo43.74680.37616NoNoYesYes97
28E2.I513 E2x51 lh_on_allo41.73510.873988NoNoYesYes99
297x37 E2.I513 lh_on_allo43.56040.936261NoNoNoNo89
307x34 7x37 lh_on_allo43.64650NoNoNoNo98
31Allo1 E2x51 lh_on_allo43.81120YesNoYesYes09
327x41 7x42 lh_on_allo15.42920.716685YesYesNoNo79
337x42 7x46 lh_on_allo14.74550NoNoYesNo99
342x43 2x44 lh_on_allo32.39420NoNoYesNo78
352x44 2x45 lh_on_allo40.73631.75194YesNoYesYes87
362x45 4x50 lh_on_allo47.27270.198339YesYesNoYes75
372x48 4x50 lh_on_allo48.78680.563341NoNoNoYes55
382x48 2x52 lh_on_allo49.12920NoNoYesYes57
392x52 2x56 lh_on_allo50.45391.88764YesYesYesYes77
402x43 7x53 lh_on_allo31.71051.63531NoNoYesYes79
412x50 7x49 lh_on_allo17.81820.700846YesYesYesYes99
425x58 7x53 lh_on_allo20.6590YesYesYesYes99
43NT.I135 NT.T133 Shared24.416725.7024YesYesYesYes78
44NT.?131 NT.T133 Shared25.526617.3556YesYesYesYes78
45Lig NT.D157 Shared14.712610.1481YesYesYesNo06
46NT.?126 NT.F151 Shared86.297720.7651YesNoNoYes55
47Lig NT.?183 Shared12.264312.9208YesYesYesYes07
48NT.?240 NT.F218 Shared99.225214.834YesYesNoYes28
49NT.?240 NT.?241 Shared99.492324.2892YesYesNoYes27
50NT.F265 NT.P260 Shared99.956117.7029NoYesNoYes76
51NT.F265 NT.F282 Shared99.63432.5683NoYesYesYes78
52NT.?279 NT.?280 Shared10094.6416NoNoYesNo99
53NT.?279 NT.F282 Shared99.996634.0701NoNoYesYes98
54NT.?280 NT.?353 Shared99.307698.6329YesNoNoNo99
55NT.?353 NT.E354 Shared99.771798.6393NoNoYesYes97
562x56 E2x51 Shared54.85685.6141YesYesYesYes79
577x41 E2x51 Shared31.079465.1042YesYesYesYes79
582x50 7x46 Shared25.647227.5796YesYesYesNo99
592x53 7x46 Shared14.697727.7891NoNoYesNo89
602x53 7x41 Shared15.030628.2484NoNoYesYes87
617x45 7x49 Shared14.866723.0653NoNoYesYes99
62Lig NT.?127 lh_on011.4306YesYesYesYes06
63NT.?126 NT.?127 lh_on3.157310.7863YesNoYesYes56
64Lig NT.E148 lh_on011.0577YesYesNoNo05
65NT.?126 NT.E148 lh_on0.44923610.7035YesNoNoNo55
66NT.?113 NT.I114 lh_on4.2236114.2048YesYesNoYes18
67NT.I114 NT.I135 lh_on026.6458NoYesYesYes87
68NT.F186 NT.I164 lh_on6.2898711.7736YesYesNoNo87
69NT.I164 NT.V189 lh_on5.0340911.0858NoNoNoNo77
70NT.M213 NT.P238 lh_on010.3147NoNoNoNo69
71NT.F218 NT.P238 lh_on0.33481910.6052NoYesNoNo89
72NT.?240 NT.R219 lh_on2.3336119.0629YesYesNoNo21
73NT.H192 NT.R219 lh_on0.66766916.8657NoNoNoNo51
74NT.?220 NT.H192 lh_on016.316NoNoNoNo55
75NT.?220 NT.N195 lh_on0.89819115.2174NoNoNoYes55
76NT.N195 NT.Q170 lh_on011.4104NoYesNoNo53
77NT.?171 NT.Q170 lh_on9.3215110.8673NoNoNoNo43
78NT.?171 NT.F145 lh_on8.8832310.3018NoNoNoNo43
79NT.F186 NT.N184 lh_on8.3521912.1538YesYesYesYes89
80Lig NT.R247 lh_on4.4043765.2413YesYesNoNo05
81NT.I245 NT.L242 lh_on014.0983NoNoNoNo89
82NT.?241 NT.L242 lh_on0.33481928.396NoYesNoNo79
83NT.I245 NT.L248 lh_on0.33481914.4806NoNoNoNo89
84NT.F265 NT.L248 lh_on014.7322NoYesNoNo79
85NT.?279 NT.?343 lh_on0.66935666.2795NoNoNoNo99
86NT.?343 NT.R342 lh_on065.9937NoNoNoNo94
87NT.E270 NT.R342 lh_on0.44895565.854NoNoNoNo64
88NT.E270 NT.R247 lh_on1.3457465.7582NoNoNoNo65
89NT.L237 NT.L242 lh_on014.73NoNoNoNo79
90NT.L237 NT.P260 lh_on6.9187415.739NoNoNoYes76
91E2.S512 NT.E354 lh_on098.6141NoNoYesYes97
923x29 E2.?508 lh_on0.53244913.027NoNoYesYes98
933x29 3x32 lh_on0.94457613.2185NoNoNoNo98
942x56 3x32 lh_on0.56449713.4989YesYesNoNo78
952x56 2x57 lh_on2.6900798.5854YesYesNoNo78
961x39 2x57 lh_on2.2430998.653NoYesNoNo98
971x39 NT.M357 lh_on0100NoYesNoNo97
982x64 NT.M357 lh_on0.335197.553NoYesNoNo97
992x64 NT.I356 lh_on2.0035797.9025NoYesNoNo98
100E2.S512 NT.I356 lh_on097.9176NoNoNoNo98
101E2.?508 E2x50 lh_on0.06353416.5406YesYesYesYes89
102E2x50 E2x51 lh_on019.9408YesYesYesYes99
103E2.?508 E2x52 lh_on4.0605516.4539YesYesNoNo89
104E2x51 E2x52 lh_on0.72670516.7393YesYesNoNo99
1051x50 2x50 lh_on7.9423114.4867NoYesYesYes99
1061x50 2x47 lh_on7.3415511.422NoYesYesNo98
1071x54 2x47 lh_on0.76381410.8647NoNoYesNo58
1081x54 2x44 lh_on0.43152510.3284NoNoYesNo58
1091x57 2x44 lh_on8.7651611.6401NoNoYesNo68
1102x46 3x42 lh_on1.145315.1073NoYesNoNo88
1112x46 2x50 lh_on014.2037NoYesYesYes89
1122x46 7x49 lh_on1.9105214.689NoYesYesYes89
1136x47 7x45 lh_on7.4559734.0668YesYesNoNo99
1146x47 7x41 lh_on035.3022YesYesYesYes97
1152x46 7x53 lh_on015.8866NoYesYesYes89
1165x54 6x44 lh_on010.9853NoNoNoNo88
1176x44 7x45 lh_on6.6297513.6004NoNoNoNo89
1184x60 5x39 lh_on0.40594331.3833NoNoYesYes97
1194x60 E2.?508 lh_on0.49843332.2098NoNoYesYes98
1205x41 6x60 lh_on0.53722812.8352NoNoNoNo66
1216x56 6x60 lh_on0.80513914.2577NoNoNoNo76
1225x44 6x56 lh_on1.0724916.3599NoYesNoNo97
1235x39 5x40 lh_on7.4064910.3151YesYesNoNo76
1245x39 5x43 lh_on4.0692710.3151YesYesNoNo76
1256x35 6x36 lh_on2.2107611.3888YesNoNoNo79
1266x36 6x39 lh_on0.44192712.197NoNoNoNo95
1276x39 7x52 lh_on013.0044NoNoNoNo59
1287x52 7x53 lh_on014.617NoNoYesYes99

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Midway



Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Node1Node2OwnerNet1LinkStrengthNet2LinkStrengthComm1Comm2Node1ShellNode2Shell
NT.?58NT.A57Shared9.196.131112
NT.?58NT.L59Shared8.088.081112
NT.?58NT.Q82Shared16.8315.531111
LigNT.?58Shared17.7211.041101
NT.Q82NT.S81Shared7.225.781112
NT.Q106NT.S81lh_on4.3300112
NT.N107NT.Q82Shared11.887.921111
LigNT.Q82Shared13.569.521101
LigNT.E102Shared18.7817.521101
NT.L104NT.Q106lh_on15.9700121
NT.N107NT.Q106Shared18.497.921111
NT.N107NT.N132lh_on5.4501111
LigNT.N107Shared12.0412.561101
NT.?109NT.N110Shared8.198.191112
NT.F151NT.L125lh_on6.0900122
NT.?126NT.?127Shared12.8514.460111
NT.?126NT.E148Shared6.327.110111
NT.?126NT.F151Shared10.176.540112
NT.?127NT.S129Shared10.228.761112
NT.?127NT.I152lh_on5.5501111
NT.?127NT.E154Shared14.189.021111
LigNT.?127lh_on26.7701101
NT.E154NT.S129Shared10.0614.371112
NT.?131NT.N132Shared5.8811.761121
NT.?131NT.?156Shared30.1631.751122
NT.?131NT.D157Shared5.814.361121
LigNT.N132Shared16.3812.881101
NT.?134NT.R136Shared8.486.360022
NT.?134NT.H160lh_on6.7300021
LigNT.E148lh_on9.0201101
LigNT.S149Shared16.534.481101
LigNT.N150Shared13.2219.281101
NT.I152NT.T178Shared4.567.61011
LigNT.I152lh_on11.101101
NT.?180NT.E154lh_on8.701011
LigNT.E154Shared9.636.321101
NT.?156NT.D157Shared17.4414.531121
NT.?156NT.?182Shared15.864.321121
NT.?156NT.N184Shared14.713.231122
LigNT.D157Shared16.888.341101
LigNT.H160lh_on7.7101101
NT.?180NT.L181Shared6.614.951012
NT.?180NT.?182lh_on16.8701011
LigNT.?180lh_on4.8201101
NT.?182NT.?183Shared15.2615.261111
NT.?182NT.N184Shared10.689.351112
NT.?182NT.E203Shared16.7519.331112
NT.?182NT.?205Shared8.0313.651112
LigNT.?182Shared13.8915.031101
NT.?183NT.N184Shared8.384.791112
NT.?183NT.N207Shared5.995.991112
LigNT.?183Shared5.35.31101
NT.N184NT.N207lh_on5.4501122
NT.?205NT.E206Shared9.494.740021
LigNT.E206lh_on16.5601101
NT.R247NT.T226Shared5.179.061112
NT.E270NT.R247Shared5.829.30021
LigNT.R247Shared7.2111.531101
NT.?331NT.D330Shared6.611.881111
LigNT.D330lh_on25.2401101
NT.?331NT.E332Shared7.736.441112
NT.?331NT.?333Shared6.556.551112
NT.?333NT.E332lh_on6.4401022
LigNT.?328lh_on4.2501101
LigNT.?77Shared4.245.41101
LigNT.?109Shared3.628.581101
NT.?328NT.W329lh_on2.9801012
NT.H209NT.L159lh_on2.5700021
LigNT.R53lh_on2.2601101
NT.D84NT.S85lh_on1.4700012
NT.?77NT.R53lh_on_allo04.350111
NT.?77NT.E102lh_on_allo011.860111
LigNT.D84lh_on_allo014.451101
NT.E102NT.L104lh_on_allo06.630112
NT.?127NT.E102lh_on_allo07.731111
NT.?127NT.L104lh_on_allo06.731112
LigNT.Q106lh_on_allo014.021101
NT.?109NT.?134lh_on_allo04.321112
LigNT.?126lh_on_allo04.821101
NT.D157NT.N132lh_on_allo012.121111
NT.H160NT.R136lh_on_allo016.931012
NT.N150NT.S149lh_on_allo04.470111
NT.E175NT.S149lh_on_allo08.620021
NT.?156NT.E154lh_on_allo04.261121
LigNT.T178lh_on_allo04.31101
NT.?180NT.E203lh_on_allo05.531012
NT.E206NT.S231lh_on_allo05.751012
LigNT.?331lh_on_allo05.911101
NT.?126NT.L125lh_on_allo04.130112
NT.?77NT.I76lh_on_allo01.70112
LigNT.L159lh_on_allo01.491101
NT.R53NT.T52lh_on_allo01.290012

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
Id Description
lh_on_allo 7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
lh_on 7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
Network Difference
Value lh_on_allo lh_on
Imin 4.22 4.3
Number of Linked Nodes 543 548
Number of Specific Nodes 5 (0.92%) 10  (1.82%)
Number of Shared Nodes 538 (99.08%) 538  (98.18%)
Number of Links 627 641
Number of Specific Links 198 (31.58%) 212  (33.07%)
Number of Shared Links 429 (68.42%) 429  (66.93%)
Number of Hubs 76 85
Number of Specific Hubs 29 (38.16%) 38  (44.71%)
Number of Shared Hubs 47 (61.84%) 47  (55.29%)
Average % Shared Neighbours (Jaccard) 53.72
Average % Shared Neighbours (Otsuka) 64.69
Average % Shared Neighbours (Overlap Coefficient) 76.34
Average % Shared Cliques (k3-6) 81.79
Graphlets Similarity 0.67531
Paths Difference
Value lh_on_allo lh_on
Number Of Nodes in MetaPath 58 85
Specific Nodes in MetaPath 28 (48.28%) 55  (64.71%)
Shared Nodes in MetaPath 538 (99.08%) 538  (99.08%)
Number Of Links MetaPath 61 86
Specific Links in MetaPath 42 (68.85%) 67  (77.91%)
Shared Links in MetaPath 429 (68.42%) 429  (68.42%)
Number of Shortest Paths 492543 439130
Length Of Smallest Path 3 3
Average Path Length 29.2901 23.7252
Length of Longest Path 53 50
Minimum Path Strength 1.24 1.24
Average Path Strength 8.00896 8.54776
Maximum Path Strength 23.1 26.58
Minimum Path Correlation 0.7 0.71
Average Path Correlation 0.974889 0.977516
Maximum Path Correlation 1 1
Minimum % Of Corr. Nodes 2.94118 4
Average % Of Corr. Nodes 48.4489 58.9295
Maximum % Of Corr. Nodes 100 100
Minimum Path Hubs % 0 0
Average Path Hubs % 40.4616 40.1829
Maximum Path Hubs % 100 100

Details about the values in these tables can be found in the corresponding documentation page .

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