psnGPCR

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Orange: nodes, hubs and links specific of lipid_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of lipid_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	lipid_off Int. Strength	lipid_on Int. Strength	lipid_off Hub1?	lipid_on Hub1?	lipid_off Hub2?	lipid_on Hub2?	ConSurf1	ConSurf2
1	E1	NT	lipid_off	100	0	No	No	Yes	Yes	4	4
2	2x64	NT	lipid_off	100	0	No	No	Yes	Yes	4	4
3	3x25	NT	lipid_off	100	0	Yes	No	Yes	Yes	9	4
4	Lig	NT	lipid_off	100	0	Yes	Yes	Yes	Yes	0	4
5	1x35	1x39	lipid_off	100	0	No	No	No	No	5	7
6	1x53	7x53	lipid_off	100	0	No	No	Yes	Yes	9	9
7	3x33	5x43	lipid_off	100	0	Yes	No	No	No	6	6
8	3x40	5x50	lipid_off	100	0	No	No	No	No	7	8
9	3x48	3x52	lipid_off	100	0	No	No	No	No	7	5
10	3x49	3x50	lipid_off	100	0	Yes	Yes	Yes	No	9	9
11	3x49	I2x57	lipid_off	100	0	Yes	Yes	No	No	9	6
12	3x50	3x53	lipid_off	100	0	Yes	No	No	No	9	8
13	5x40	E2	lipid_off	100	0	No	No	Yes	Yes	5	4
14	5x40	6x59	lipid_off	100	0	No	No	No	No	5	4
15	6x54	7x34	lipid_off	100	0	No	No	No	No	4	4
16	7x39	Lig	lipid_off	100	0	No	No	Yes	Yes	5	0
17	2x39	3x50	lipid_off	100	0	Yes	No	Yes	No	8	9
18	3x50	6x34	lipid_off	100	0	Yes	No	No	No	9	7
19	6x55	Lig	lipid_off	100	0	No	No	Yes	Yes	6	0
20	1x35	2x64	lipid_off	100	0	No	No	No	No	5	4
21	2x63	E1x50	lipid_off	100	0	No	No	Yes	No	3	0
22	3x25	E1x50	lipid_off	100	0	Yes	No	Yes	No	9	0
23	6x58	7x31	lipid_off	100	0	Yes	No	No	No	4	2
24	6x58	7x34	lipid_off	100	0	Yes	No	No	No	4	4
25	I4	I4	lipid_off	100	0	Yes	No	Yes	No	0	0
26	E3	NT	lipid_off	100	0	Yes	Yes	Yes	Yes	1	4
27	7x27	NT	lipid_off	100	0	No	No	Yes	Yes	1	4
28	1x31	1x32	lipid_off	20	0	No	No	No	No	2	4
29	1x39	7x42	lipid_off	42.5	0	No	No	No	No	7	7
30	3x43	6x44	lipid_off	40	0	No	No	No	Yes	8	9
31	7x49	7x53	lipid_off	66.6667	0	Yes	No	Yes	Yes	9	9
32	3x50	6x33	lipid_off	56.6667	0	Yes	No	No	No	9	8
33	1x45	1x49	lipid_off	46.6667	0	No	No	No	No	4	8
34	5x51	6x49	lipid_off	60	0	Yes	No	No	No	6	5
35	3x44	5x54	lipid_off	60	0	No	No	No	No	7	8
36	7x28	NT	lipid_off	60	0	No	No	Yes	Yes	3	4
37	6x51	7x41	lipid_off	50	0	No	No	No	No	7	7
38	1x27	7x31	lipid_off	40	0	No	No	No	No	0	2
39	5x54	6x41	lipid_off	33.3333	0	No	No	No	No	8	8
40	2x49	4x50	lipid_off	40	0	No	No	No	No	8	9
41	3x43	6x41	lipid_off	50	0	No	No	No	No	8	8
42	4x59	5x39	lipid_off	70	0	No	No	No	No	5	7
43	3x46	6x37	lipid_off	46.6667	0	No	No	No	No	9	8
44	6x40	7x49	lipid_off	66.6667	0	No	No	Yes	No	8	9
45	1x30	7x32	lipid_off	40	0	No	No	No	No	5	1
46	1x42	7x47	lipid_off	48.3333	0	No	No	No	No	6	7
47	7x26	7x30	lipid_off	20	0	No	No	No	No	0	3
48	1x32	2x67	lipid_off	23.3333	0	No	No	No	No	4	0
49	6x29	6x32	lipid_off	36.6667	0	No	No	No	Yes	6	7
50	7x62	I4	lipid_off	20	0	No	No	Yes	No	0	0
51	3x54	5x65	lipid_off	40	0	No	No	Yes	No	9	8
52	6x57	7x30	lipid_off	52.5	0	No	No	No	No	4	3
53	7x26	E3	lipid_off	26.6667	0	No	No	Yes	Yes	0	1
54	3x52	3x56	lipid_off	30	0	No	No	No	Yes	5	5
55	2x42	4x42	lipid_off	35	0	Yes	No	No	No	8	7
56	1x30	1x34	lipid_off	40	0	No	No	No	No	5	5
57	2x53	3x32	lipid_off	40	0	No	No	No	No	8	7
58	6x58	6x62	lipid_off	23.3333	0	Yes	No	No	No	4	0
59	5x46	5x50	lipid_off	42.5	0	No	No	No	No	6	8
60	7x28	7x32	lipid_off	26.6667	0	No	No	No	No	3	1
61	6x37	7x55	lipid_off	20	0	No	No	No	No	8	5
62	6x33	7x59	lipid_off	20	0	No	No	No	No	8	0
63	5x65	6x31	lipid_off	20	0	Yes	No	No	No	8	5
64	2x37	I1	lipid_off	26.6667	0	No	No	No	No	5	7
65	3x30	4x61	lipid_off	40	0	No	No	No	No	6	5
66	6x43	7x48	lipid_off	33.3333	0	No	No	No	No	6	6
67	2x66	E1x51	lipid_off	20	0	No	No	No	No	4	0
68	4x59	4x63	lipid_off	20	0	No	No	No	No	5	5
69	3x33	4x61	lipid_off	30	0	Yes	No	No	No	6	5
70	7x54	8x51	lipid_off	36.6667	0	No	No	No	No	7	8
71	1x57	1x61	lipid_off	23.3333	0	Yes	Yes	No	No	7	0
72	5x58	5x62	lipid_off	40	0	Yes	Yes	No	No	9	6
73	2x41	4x39	lipid_off	21.6667	0	Yes	Yes	No	No	3	1
74	6x47	7x40	lipid_off	23.3333	0	No	No	No	No	8	7
75	5x41	5x45	lipid_off	30	0	No	No	No	No	4	3
76	6x60	E3	lipid_off	26.6667	0	No	No	Yes	Yes	5	1
77	1x47	2x55	lipid_off	20	0	No	No	No	No	6	4
78	8x50	I1x50	lipid_off	20	0	No	No	No	No	8	9
79	2x42	4x45	lipid_off	42.5	0	Yes	No	No	No	8	5
80	2x38	4x38	lipid_off	20	0	No	No	No	No	5	8
81	6x36	7x53	lipid_off	20	0	No	No	Yes	Yes	8	9
82	6x29	8x49	lipid_off	30	0	No	No	Yes	No	6	6
83	I2x55	I2x57	lipid_off	20	0	No	No	No	No	4	6
84	3x50	6x30	lipid_off	30	0	Yes	No	No	Yes	9	7
85	8x49	I1x49	lipid_off	30	0	Yes	No	No	No	6	5
86	2x52	3x31	lipid_off	20	0	No	No	Yes	No	6	4
87	5x51	5x55	lipid_off	22.5	0	Yes	No	No	No	6	5
88	6x35	6x39	lipid_off	23.3333	0	No	No	No	No	7	7
89	8x58	8x59	lipid_off	20	0	No	No	Yes	No	5	0
90	5x53	5x57	lipid_off	11.6667	0	No	No	No	No	6	7
91	4x40	I2x56	lipid_off	25.8333	0	No	No	No	No	4	4
92	8x48	8x51	lipid_off	30	0	No	No	No	No	5	8
93	5x63	5x67	lipid_off	30	0	No	No	No	No	3	5
94	5x52	5x56	lipid_off	30	0	No	No	No	No	4	4
95	2x38	8x62	lipid_off	20	0	No	No	No	No	5	0
96	2x39	8x58	lipid_off	20	0	Yes	No	No	No	8	5
97	1x37	1x41	lipid_off	6.66667	0	No	No	No	No	4	4
98	8x49	8x52	lipid_off	16.6667	0	Yes	No	No	No	6	4
99	2x39	I4	lipid_off	20	0	Yes	No	Yes	No	8	0
100	6x28	I2x51	lipid_off	20	0	No	No	No	No	4	7
101	3x23	3x27	lipid_off	10	0	No	No	No	No	1	5
102	3x41	4x52	lipid_off	22.5	0	No	No	No	No	5	5
103	1x43	1x44	lipid_off	20	0	No	No	No	No	6	5
104	5x62	5x66	lipid_off	5	0	No	No	No	No	6	5
105	5x51	6x46	lipid_off	10	0	Yes	No	No	No	6	5
106	7x33	7x36	lipid_off	20	0	No	No	No	No	4	4
107	8x59	8x63	lipid_off	20	0	Yes	No	No	No	0	0
108	7x61	I4	lipid_off	20	0	No	No	Yes	No	0	0
109	5x65	I3	lipid_off	20	0	Yes	No	No	Yes	8	3.4
110	6x25	6x28	lipid_off	20	0	No	No	No	No	3	4
111	6x53	6x57	lipid_off	6.66667	0	No	No	No	No	5	4
112	1x59	1x60	lipid_off	10	0	Yes	No	No	No	5	6
113	7x27	7x29	lipid_off	20	0	No	No	No	No	1	4
114	4x43	4x47	lipid_off	6.66667	0	No	No	No	No	1	4
115	2x36	I1	lipid_off	20	0	No	No	No	No	0	7
116	6x28	8x48	lipid_off	20	0	No	No	No	No	4	5
117	I2x50	I2x51	lipid_off	12.5	0	No	No	No	No	8	7
118	1x25	E3	lipid_off	20	0	No	No	Yes	Yes	0	1
119	5x32	5x35	lipid_off	10	0	No	No	No	No	0	0
120	4x54	4x58	lipid_off	0	0	No	No	No	No	4	5
121	1x26	7x28	lipid_off	10	0	No	No	No	No	0	3
122	5x29	E3	lipid_off	6.66667	0	No	No	Yes	Yes	0	1
123	6x461	6x47	lipid_off	0	0	No	No	No	No	0	8
124	4x48	4x52	lipid_off	3.33333	0	No	No	No	No	3	5
125	1x57	7x57	lipid_off	10	0	Yes	Yes	No	No	7	0
126	8x61	8x62	lipid_off	10	0	No	No	No	No	0	0
127	8x56	8x59	lipid_off	10	0	No	No	Yes	No	3	0
128	2x551	3x31	lipid_off	13.3333	0	No	No	Yes	No	0	4
129	7x23	7x26	lipid_off	10	0	No	No	No	No	0	0
130	4x55	4x56	lipid_off	0	0	No	No	No	No	3	5
131	5x65	5x69	lipid_off	6.66667	0	Yes	No	No	No	8	5
132	1x33	NT	lipid_off	10	0	No	No	Yes	Yes	5	4
133	I2x54	I2x55	lipid_off	6.66667	0	No	No	No	No	4	4
134	5x27	5x30	lipid_off	6.66667	0	No	No	No	No	0	0
135	6x27	6x31	lipid_off	0	0	No	No	No	No	4	5
136	6x64	E2	lipid_off	0	0	No	No	Yes	Yes	0	4
137	4x51	4x55	lipid_off	0	0	No	No	No	No	4	3
138	5x31	E2	lipid_off	6.66667	0	No	No	Yes	Yes	0	4
139	5x28	NT	lipid_off	0	0	No	No	Yes	Yes	0	4
140	1x59	8x60	lipid_off	3.33333	0	Yes	No	No	No	5	0
141	7x24	NT	lipid_off	0	0	No	No	Yes	Yes	0	4
142	7x23	7x25	lipid_off	0	0	No	No	No	No	0	0
143	5x70	5x71	lipid_off	0	0	No	No	No	No	5	0
144	5x27	5x29	lipid_off	0	0	No	No	No	No	0	0
145	8x64	CT	lipid_off	0	0	No	No	No	No	0	0
146	NT	NT	Shared	100	100	Yes	Yes	Yes	Yes	4	4
147	E2	NT	Shared	100	100	Yes	Yes	Yes	Yes	4	4
148	7x31	NT	Shared	100	25	No	No	Yes	Yes	2	4
149	1x43	2x57	Shared	100	100	No	No	No	Yes	6	7
150	1x43	2x58	Shared	100	43.75	No	No	No	No	6	7
151	1x49	7x50	Shared	100	58.3333	No	No	No	No	8	9
152	1x50	2x47	Shared	100	50.5208	Yes	Yes	No	No	9	9
153	1x50	2x50	Shared	100	100	Yes	Yes	Yes	Yes	9	9
154	1x50	7x50	Shared	100	100	Yes	Yes	No	No	9	9
155	1x57	2x43	Shared	100	100	Yes	Yes	No	No	7	8
156	1x57	2x44	Shared	100	100	Yes	Yes	No	No	7	6
157	2x40	I1x50	Shared	100	100	Yes	Yes	No	No	9	9
158	2x37	2x40	Shared	100	47.9167	No	No	Yes	Yes	5	9
159	2x41	4x43	Shared	100	28.4722	Yes	Yes	No	No	3	1
160	2x43	7x53	Shared	100	25.6944	No	No	Yes	Yes	8	9
161	2x45	3x42	Shared	100	100	No	No	No	No	9	8
162	2x45	4x46	Shared	100	100	No	No	No	No	9	8
163	2x45	4x50	Shared	100	100	No	No	No	No	9	9
164	2x46	3x42	Shared	100	100	No	Yes	No	No	9	8
165	2x50	7x46	Shared	100	100	Yes	Yes	No	No	9	9
166	2x50	7x49	Shared	100	100	Yes	Yes	Yes	No	9	9
167	2x53	3x35	Shared	100	100	No	No	No	No	8	7
168	2x57	7x42	Shared	100	100	No	Yes	No	No	7	7
169	2x60	3x28	Shared	100	100	No	No	No	No	4	6
170	2x60	Lig	Shared	100	100	No	No	Yes	Yes	4	0
171	2x61	2x65	Shared	100	17.8571	No	Yes	No	No	5	4
172	2x62	2x66	Shared	100	29.1667	No	No	No	No	5	4
173	2x63	E1	Shared	100	45.8333	No	No	No	No	3	4
174	3x22	3x26	Shared	100	100	No	No	No	No	3	5
175	3x22	E2	Shared	100	100	No	No	Yes	Yes	3	4
176	3x25	E2	Shared	100	100	Yes	No	Yes	Yes	9	4
177	3x26	E2	Shared	100	100	No	No	Yes	Yes	5	4
178	3x29	E2	Shared	100	100	No	Yes	Yes	Yes	4	4
179	3x29	Lig	Shared	100	100	No	Yes	Yes	Yes	4	0
180	3x32	Lig	Shared	100	100	No	No	Yes	Yes	7	0
181	3x33	Lig	Shared	100	100	Yes	No	Yes	Yes	6	0
182	3x36	6x48	Shared	100	100	No	No	Yes	Yes	7	8
183	3x37	5x43	Shared	100	58.3333	No	No	No	No	6	6
184	3x38	4x50	Shared	100	100	No	No	No	No	7	9
185	3x42	4x49	Shared	100	100	No	No	No	No	8	6
186	3x47	5x58	Shared	100	100	No	No	Yes	Yes	8	9
187	3x51	3x55	Shared	100	100	Yes	Yes	No	No	8	6
188	3x51	5x57	Shared	100	100	Yes	Yes	No	No	8	7
189	3x51	5x60	Shared	100	100	Yes	Yes	Yes	Yes	8	4
190	3x54	5x61	Shared	100	52.7778	No	No	No	No	9	9
191	3x55	3x56	Shared	100	100	No	No	No	Yes	6	5
192	4x60	E2	Shared	100	100	No	No	Yes	Yes	6	4
193	4x60	5x39	Shared	100	100	No	No	No	No	6	7
194	E2	E2	Shared	100	100	Yes	Yes	Yes	Yes	4	4
195	5x36	E2	Shared	100	100	No	No	Yes	Yes	5	4
196	5x39	E2	Shared	100	100	No	No	Yes	Yes	7	4
197	6x58	E2	Shared	100	100	Yes	No	Yes	Yes	4	4
198	E2	E3	Shared	100	100	Yes	Yes	Yes	Yes	4	1
199	7x34	E2	Shared	100	100	No	No	Yes	Yes	4	4
200	E2	Lig	Shared	100	100	Yes	Yes	Yes	Yes	4	0
201	5x42	5x46	Shared	100	100	No	No	No	No	6	6
202	5x44	6x56	Shared	100	34.3502	No	No	No	No	5	6
203	5x58	6x38	Shared	100	18.75	Yes	Yes	No	No	9	6
204	6x36	7x56	Shared	100	100	No	No	No	No	8	7
205	6x47	7x45	Shared	100	100	No	No	No	No	8	9
206	6x48	7x41	Shared	100	100	Yes	Yes	No	No	8	7
207	6x48	7x45	Shared	100	100	Yes	Yes	No	No	8	9
208	6x50	7x37	Shared	100	44.4444	No	No	No	No	9	5
209	6x51	6x55	Shared	100	100	No	No	No	No	7	6
210	6x54	7x37	Shared	100	100	No	No	No	No	4	5
211	7x38	Lig	Shared	100	100	No	No	Yes	Yes	6	0
212	7x45	7x49	Shared	100	100	No	No	Yes	No	9	9
213	8x47	8x50	Shared	100	50.6944	No	No	No	No	8	8
214	2x39	3x49	Shared	100	45.8333	Yes	No	Yes	Yes	8	9
215	5x51	6x45	Shared	100	50	Yes	No	No	No	6	6
216	6x44	6x48	Shared	100	100	No	Yes	Yes	Yes	9	8
217	1x55	1x59	Shared	100	39.9058	No	No	Yes	No	4	5
218	2x42	3x45	Shared	100	100	Yes	No	No	No	8	6
219	2x46	7x49	Shared	100	100	No	Yes	Yes	No	9	9
220	2x64	Lig	Shared	100	100	No	No	Yes	Yes	4	0
221	3x40	6x48	Shared	100	100	No	No	Yes	Yes	7	8
222	5x40	6x55	Shared	100	100	No	No	No	No	5	6
223	E1x49	E2	Shared	100	20.1389	No	No	Yes	Yes	0	4
224	E1x50	E1x52	Shared	100	36.1111	Yes	No	No	No	0	0
225	E1x50	E2x50	Shared	100	100	Yes	No	No	No	0	0
226	3x25	E2x50	Shared	100	100	Yes	No	No	No	9	0
227	3x29	4x65	Shared	100	100	No	Yes	No	No	4	0
228	3x47	5x54	Shared	100	100	No	No	No	No	8	8
229	E2	E2x51	Shared	100	100	Yes	Yes	No	No	4	0
230	E2	E2x52	Shared	100	100	Yes	Yes	No	No	4	0
231	5x47	6x52	Shared	100	100	No	No	No	No	8	7
232	E3	E3	Shared	100	100	Yes	Yes	Yes	Yes	1	1
233	E1x501	NT	Shared	20	16.6667	No	No	Yes	Yes	0	4
234	1x54	2x47	Shared	40	49.6528	No	No	No	No	7	9
235	3x41	4x49	Shared	73.3333	100	No	No	No	No	5	6
236	5x60	5x64	Shared	50	100	Yes	Yes	No	No	4	5
237	2x50	3x39	Shared	42.5	100	Yes	Yes	No	No	9	9
238	3x30	4x62	Shared	26.6667	20.8333	No	No	No	No	6	5
239	1x60	I1x50	Shared	40	33.3333	No	No	No	No	6	9
240	3x38	4x53	Shared	60	64.2361	No	No	No	No	7	8
241	2x42	3x49	Shared	60	100	Yes	No	Yes	Yes	8	9
242	5x38	E2	Shared	40	100	No	No	Yes	Yes	5	4
243	1x50	2x51	Shared	30	100	Yes	Yes	No	Yes	9	7
244	3x51	5x61	Shared	50	100	Yes	Yes	No	No	8	9
245	1x39	2x61	Shared	46.6667	59.7222	No	No	No	Yes	7	5
246	3x21	3x24	Shared	40	50	No	No	No	No	7	5
247	5x47	5x51	Shared	26.6667	56.0764	No	No	Yes	No	8	6
248	6x49	6x50	Shared	52.5	100	No	No	No	No	5	9
249	5x37	6x59	Shared	60	50	No	No	No	No	3	4
250	1x46	7x47	Shared	40	100	No	No	No	No	7	7
251	3x37	4x56	Shared	60	100	No	No	No	No	6	5
252	1x45	7x47	Shared	50	46.5278	No	No	No	No	4	7
253	6x40	7x52	Shared	47.5	52.9101	No	No	No	No	8	9
254	1x28	1x31	Shared	40	17.2619	No	No	No	No	6	2
255	6x61	E3	Shared	36.6667	100	No	No	Yes	Yes	3	1
256	I2x53	I2x57	Shared	26.6667	100	No	Yes	No	No	7	6
257	2x42	3x46	Shared	60	100	Yes	No	No	No	8	9
258	5x58	6x37	Shared	56.6667	100	Yes	Yes	No	No	9	8
259	1x51	2x51	Shared	60	33.3333	No	No	No	Yes	3	7
260	5x56	5x60	Shared	36.6667	36.1111	No	No	Yes	Yes	4	4
261	5x33	5x36	Shared	50	25	No	No	No	No	0	5
262	2x56	3x31	Shared	50	100	No	No	Yes	No	5	4
263	6x54	7x33	Shared	20	45.8333	No	No	No	No	4	4
264	5x47	5x48	Shared	20	16.6667	No	No	No	No	8	5
265	1x47	2x51	Shared	50	51.3889	No	No	No	Yes	6	7
266	4x38	4x41	Shared	30	100	No	No	No	No	8	5
267	2x59	3x28	Shared	50	43.75	No	No	No	No	7	6
268	1x32	NT	Shared	30	25	No	No	Yes	Yes	4	4
269	5x41	6x59	Shared	50	100	No	No	No	No	4	4
270	3x24	E1x52	Shared	36.6667	30.9524	No	No	No	No	5	0
271	3x34	4x54	Shared	42.5	100	No	No	No	No	5	4
272	5x58	6x42	Shared	36.6667	16.6667	Yes	Yes	No	No	9	6
273	7x35	Lig	Shared	60	100	No	No	Yes	Yes	4	0
274	1x46	2x54	Shared	29.1667	50	No	No	No	No	7	7
275	3x33	4x57	Shared	50	47.0238	Yes	No	No	No	6	7
276	1x38	7x39	Shared	43.3333	100	No	No	No	No	5	5
277	3x34	4x57	Shared	16.6667	67.3611	No	No	No	No	5	7
278	2x38	4x42	Shared	24.1667	44.4444	No	No	No	No	5	7
279	4x64	E2	Shared	23.3333	100	No	No	Yes	Yes	0	4
280	1x40	2x61	Shared	30	30.0926	No	No	No	Yes	3	5
281	1x57	2x40	Shared	35	44.4444	Yes	Yes	Yes	Yes	7	9
282	1x42	7x43	Shared	20	47.4826	No	No	No	No	6	5
283	1x54	2x48	Shared	16.6667	30.5556	No	No	No	No	7	6
284	3x56	I2x52	Shared	40	100	No	Yes	No	No	5	5
285	5x44	6x52	Shared	26.6667	36.1111	No	No	No	No	5	7
286	2x41	4x42	Shared	35.8333	40.2778	Yes	Yes	No	No	3	7
287	7x43	7x48	Shared	29.1667	40.2778	No	No	No	No	5	6
288	E1x49	E1x51	Shared	29.1667	23.6111	No	No	No	No	0	0
289	2x40	8x49	Shared	20	20.8333	Yes	Yes	Yes	No	9	6
290	5x60	5x63	Shared	35	35.9127	Yes	Yes	No	No	4	3
291	1x36	2x65	Shared	36.6667	37.5	No	No	No	No	5	4
292	5x35	E2	Shared	26.6667	38.8889	No	No	Yes	Yes	0	4
293	6x39	7x52	Shared	30	22.309	No	No	No	No	7	9
294	1x49	7x51	Shared	30	36.1111	No	No	No	No	8	6
295	3x44	3x48	Shared	40	34.2593	No	No	No	No	7	7
296	1x60	8x53	Shared	40	43.0556	No	No	No	No	6	7
297	2x41	I1x51	Shared	30	22.2222	Yes	Yes	No	No	3	8
298	1x59	8x57	Shared	26.6667	25	Yes	No	No	No	5	5
299	3x27	3x31	Shared	22.5	20.8333	No	No	Yes	No	5	4
300	6x32	8x48	Shared	40	16.6667	No	Yes	No	No	7	5
301	I2x52	I2x56	Shared	25	36.1111	No	No	No	No	5	4
302	5x68	I3	Shared	26.6667	16.6667	No	No	No	Yes	7	3.4
303	E1x48	NT	Shared	20	16.6667	No	No	Yes	Yes	0	4
304	1x56	8x54	Shared	25	27.7778	No	No	No	No	8	7
305	2x56	3x32	Shared	16.6667	45.8664	No	No	No	No	5	7
306	3x44	5x53	Shared	31.6667	41.7535	No	No	No	No	7	6
307	5x55	5x59	Shared	16.6667	16.6667	No	No	No	No	5	3
308	I1x48	I1x51	Shared	30	4.94792	No	No	No	No	6	8
309	8x51	8x55	Shared	30	18.0556	No	No	No	Yes	8	5
310	1x56	8x50	Shared	25	26.6493	No	No	No	No	8	8
311	1x52	1x56	Shared	20	17.7827	No	No	No	No	7	8
312	5x37	6x63	Shared	20	16.6667	No	No	No	No	3	0
313	5x34	E2	Shared	20	17.2619	No	No	Yes	Yes	0	4
314	1x44	1x48	Shared	0	4.16667	No	No	No	No	5	3
315	4x40	4x44	Shared	20	13.9757	No	No	No	No	4	3
316	5x49	5x50	Shared	26.6667	16.6667	No	No	No	No	6	8
317	1x29	1x30	Shared	20	25	No	No	No	No	2	5
318	1x41	1x45	Shared	6.66667	2.77778	No	No	No	No	4	4
319	3x37	5x461	Shared	20	16.6667	No	No	No	No	6	0
320	1x58	2x44	Shared	16.6667	33.3333	No	No	No	No	4	6
321	7x58	7x59	Shared	10	0	No	No	No	No	0	0
322	6x26	6x29	Shared	10	10.4167	No	No	No	No	5	6
323	8x59	CT	Shared	10	4.16667	Yes	No	No	No	0	0
324	E1x47	E1x48	Shared	10	10.4167	No	No	No	No	0	0
325	6x24	6x27	Shared	0	1.78571	No	No	No	No	2	4
326	5x66	5x70	Shared	5	18.0556	No	No	No	No	5	5
327	2x38	I2x57	lipid_on	0	100	No	No	No	No	5	6
328	2x46	2x50	lipid_on	0	100	No	Yes	Yes	Yes	9	9
329	2x46	3x43	lipid_on	0	100	No	Yes	No	No	9	8
330	3x36	Lig	lipid_on	0	100	No	No	Yes	Yes	7	0
331	3x43	7x53	lipid_on	0	100	No	No	Yes	Yes	8	9
332	3x44	5x50	lipid_on	0	100	No	No	No	No	7	8
333	3x46	3x50	lipid_on	0	100	No	No	Yes	No	9	9
334	3x46	7x53	lipid_on	0	100	No	No	Yes	Yes	9	9
335	3x49	I2x53	lipid_on	0	100	Yes	Yes	No	Yes	9	7
336	3x50	5x58	lipid_on	0	100	Yes	No	Yes	Yes	9	9
337	3x50	7x53	lipid_on	0	100	Yes	No	Yes	Yes	9	9
338	3x53	I2x53	lipid_on	0	100	No	No	No	Yes	8	7
339	4x52	4x56	lipid_on	0	100	No	No	No	No	5	5
340	5x43	Lig	lipid_on	0	100	No	No	Yes	Yes	6	0
341	5x55	6x44	lipid_on	0	100	No	No	No	Yes	5	9
342	6x40	7x53	lipid_on	0	100	No	No	Yes	Yes	8	9
343	6x50	7x40	lipid_on	0	100	No	No	No	No	9	7
344	6x51	Lig	lipid_on	0	100	No	No	Yes	Yes	7	0
345	7x34	Lig	lipid_on	0	100	No	No	Yes	Yes	4	0
346	7x51	7x55	lipid_on	0	100	No	No	No	No	6	5
347	3x25	3x29	lipid_on	0	100	Yes	No	No	Yes	9	4
348	6x48	Lig	lipid_on	0	100	Yes	Yes	Yes	Yes	8	0
349	2x53	7x46	lipid_on	0	100	No	No	No	No	8	9
350	1x35	7x35	lipid_on	0	100	No	No	No	No	5	4
351	4x65	E2x52	lipid_on	0	100	No	No	No	No	0	0
352	E2x52	Lig	lipid_on	0	100	No	No	Yes	Yes	0	0
353	6x31	6x32	lipid_on	0	100	No	No	No	Yes	5	7
354	3x51	5x58	lipid_on	0	100	Yes	Yes	Yes	Yes	8	9
355	6x58	7x30	lipid_on	0	100	Yes	No	No	No	4	3
356	2x57	Lig	lipid_on	0	33.3333	No	Yes	Yes	Yes	7	0
357	5x51	6x44	lipid_on	0	50.6944	Yes	No	No	Yes	6	9
358	5x58	6x41	lipid_on	0	58.3333	Yes	Yes	No	No	9	8
359	3x26	4x61	lipid_on	0	58.3333	No	No	No	No	5	5
360	5x37	E2	lipid_on	0	41.6667	No	No	Yes	Yes	3	4
361	4x63	E2	lipid_on	0	28.2986	No	No	Yes	Yes	5	4
362	4x59	4x60	lipid_on	0	56.5724	No	No	No	No	5	6
363	7x33	E3	lipid_on	0	33.3333	No	No	Yes	Yes	4	1
364	2x57	2x61	lipid_on	0	37.4008	No	Yes	No	Yes	7	5
365	2x52	3x35	lipid_on	0	63.7153	No	No	No	No	6	7
366	1x53	2x47	lipid_on	0	50.5208	No	No	No	No	9	9
367	2x49	3x38	lipid_on	0	34.5238	No	No	No	No	8	7
368	3x41	5x50	lipid_on	0	44.4444	No	No	No	No	5	8
369	1x39	7x39	lipid_on	0	59.2593	No	No	No	No	7	5
370	6x36	8x47	lipid_on	0	16.6667	No	No	No	No	8	8
371	2x54	Lig	lipid_on	0	16.6667	No	No	Yes	Yes	7	0
372	5x64	5x68	lipid_on	0	37.5	No	No	No	No	5	7
373	I2x55	I2x56	lipid_on	0	33.3333	No	No	No	No	4	4
374	1x42	7x42	lipid_on	0	48.6111	No	No	No	No	6	7
375	3x30	4x58	lipid_on	0	40.2778	No	No	No	No	6	5
376	1x31	7x36	lipid_on	0	37.5	No	No	No	No	2	4
377	5x62	6x34	lipid_on	0	21.5278	No	No	No	No	6	7
378	5x61	5x65	lipid_on	0	41.6667	No	No	Yes	No	9	8
379	6x43	7x52	lipid_on	0	47.2222	No	No	No	No	6	9
380	4x56	5x42	lipid_on	0	37.3264	No	No	No	No	5	6
381	2x63	3x28	lipid_on	0	33.3333	No	No	No	No	3	6
382	5x66	6x30	lipid_on	0	37.037	No	No	No	Yes	5	7
383	2x40	I1	lipid_on	0	41.6667	Yes	Yes	No	No	9	7
384	2x40	8x47	lipid_on	0	33.3333	Yes	Yes	No	No	9	8
385	3x52	I2x53	lipid_on	0	40.2778	No	No	No	Yes	5	7
386	1x53	7x54	lipid_on	0	32.2049	No	No	No	No	9	7
387	5x67	6x30	lipid_on	0	16.6667	No	No	No	Yes	5	7
388	4x38	4x40	lipid_on	0	44.4444	No	No	No	No	8	4
389	3x45	4x45	lipid_on	0	30.5556	No	No	No	No	6	5
390	6x57	E3	lipid_on	0	28.001	No	No	Yes	Yes	4	1
391	8x48	8x49	lipid_on	0	28.6334	No	No	Yes	No	5	6
392	I2x51	I2x54	lipid_on	0	33.3333	No	No	No	No	7	4
393	7x55	8x51	lipid_on	0	18.75	No	No	No	No	5	8
394	8x55	8x59	lipid_on	0	19.4444	No	Yes	Yes	No	5	0
395	5x69	6x30	lipid_on	0	25	No	No	No	Yes	5	7
396	5x45	6x52	lipid_on	0	20.3704	No	No	No	No	3	7
397	4x39	4x43	lipid_on	0	31.2996	No	No	No	No	1	1
398	7x32	7x33	lipid_on	0	36.1111	No	No	No	No	1	4
399	1x59	8x53	lipid_on	0	19.7049	Yes	No	No	No	5	7
400	3x56	I2x54	lipid_on	0	17.2619	No	Yes	No	No	5	4
401	3x30	3x34	lipid_on	0	36.1111	No	No	No	No	6	5
402	3x21	3x23	lipid_on	0	25	No	No	No	No	7	1
403	1x35	7x36	lipid_on	0	22.2222	No	No	No	No	5	4
404	6x61	7x26	lipid_on	0	16.6667	No	No	No	No	3	0
405	I1x49	I1x50	lipid_on	0	32.0312	No	No	No	No	5	9
406	6x49	6x53	lipid_on	0	20.7341	No	No	No	No	5	5
407	6x28	6x32	lipid_on	0	16.6667	No	No	No	Yes	4	7
408	5x59	5x62	lipid_on	0	16.6667	No	No	No	No	3	6
409	2x51	2x55	lipid_on	0	18.75	No	Yes	No	No	7	4
410	3x56	I2x50	lipid_on	0	2.77778	No	Yes	No	No	5	8
411	7x29	7x32	lipid_on	0	16.6667	No	No	No	No	4	1
412	2x62	E1x52	lipid_on	0	16.6667	No	No	No	No	5	0
413	4x38	4x39	lipid_on	0	20.8333	No	No	No	No	8	1
414	5x62	6x33	lipid_on	0	16.6667	No	No	No	No	6	8
415	5x32	5x33	lipid_on	0	20.8333	No	No	No	No	0	0
416	1x57	7x62	lipid_on	0	16.6667	Yes	Yes	No	No	7	0
417	5x74	6x30	lipid_on	0	16.6667	No	No	No	Yes	0	7
418	7x61	7x62	lipid_on	0	16.6667	No	No	No	No	0	0
419	7x60	7x63	lipid_on	0	16.6667	No	No	No	No	0	0
420	5x52	6x44	lipid_on	0	25	No	No	No	Yes	4	9
421	6x60	6x61	lipid_on	0	20.8333	No	No	No	No	5	3
422	6x30	6x31	lipid_on	0	19.7049	No	Yes	No	No	7	5
423	6x31	6x35	lipid_on	0	26.2897	No	No	No	No	5	7
424	1x47	1x48	lipid_on	0	19.4444	No	No	No	No	6	3
425	1x28	1x29	lipid_on	0	16.6667	No	No	No	No	6	2
426	8x52	8x55	lipid_on	0	25	No	No	No	Yes	4	5
427	4x47	4x48	lipid_on	0	0	No	No	No	No	4	3
428	5x71	5x74	lipid_on	0	17.3611	No	No	No	No	0	0
429	5x72	5x75	lipid_on	0	18.0556	No	No	No	No	0	0
430	1x34	7x36	lipid_on	0	16.6667	No	No	No	No	5	4
431	4x48	4x51	lipid_on	0	2.77778	No	No	No	No	3	4
432	1x36	1x37	lipid_on	0	8.33333	No	No	No	No	5	4
433	8x52	8x56	lipid_on	0	19.2419	No	No	No	No	4	3
434	6x45	6x46	lipid_on	0	16.6667	No	No	No	No	6	5
435	1x61	2x41	lipid_on	0	16.6667	No	No	Yes	Yes	0	3
436	5x69	6x29	lipid_on	0	19.4444	No	No	No	No	5	6
437	5x67	6x27	lipid_on	0	16.6667	No	No	No	No	5	4
438	2x67	E1	lipid_on	0	16.6667	No	No	No	No	0	4
439	6x32	7x58	lipid_on	0	16.6667	No	Yes	No	No	7	0
440	5x31	5x33	lipid_on	0	16.6667	No	No	No	No	0	0
441	7x27	E3	lipid_on	0	2.77778	No	No	Yes	Yes	1	1
442	1x61	1x65	lipid_on	0	16.6667	No	No	No	No	0	0
443	3x18	3x19	lipid_on	0	16.6667	No	No	No	No	0	0
444	1x33	1x37	lipid_on	0	18.75	No	No	No	No	5	4
445	4x55	4x59	lipid_on	0	12.5	No	No	No	No	3	5
446	5x72	I3	lipid_on	0	9.72222	No	No	No	Yes	0	3.4
447	4x50	4x51	lipid_on	0	8.33333	No	No	No	No	9	4
448	5x36	6x62	lipid_on	0	4.16667	No	No	No	No	5	0
449	5x72	5x76	lipid_on	0	6.94444	No	No	No	No	0	0
450	5x78	I3	lipid_on	0	8.33333	No	No	No	Yes	0	3.4
451	7x55	I4	lipid_on	0	16.6667	No	No	Yes	No	5	0
452	3x20	E2x50	lipid_on	0	4.16667	No	No	No	No	0	0
453	8x60	8x61	lipid_on	0	8.33333	No	No	No	No	0	0
454	6x23	6x26	lipid_on	0	6.25	No	No	No	No	0	5
455	7x57	7x58	lipid_on	0	0	No	No	No	No	0	0
456	8x56	8x60	lipid_on	0	8.33333	No	No	No	No	3	0
457	7x64	I4	lipid_on	0	0	No	No	Yes	No	0	0
458	7x57	7x63	lipid_on	0	0	No	No	No	No	0	0
459	1x64	2x40	lipid_on	0	8.33333	No	No	Yes	Yes	0	9
460	1x63	1x64	lipid_on	0	8.33333	No	No	No	No	0	0
461	5x73	5x77	lipid_on	0	4.16667	No	No	No	No	0	0
462	6x64	E3	lipid_on	0	4.16667	No	No	Yes	Yes	0	1
463	3x18	3x20	lipid_on	0	4.16667	No	No	No	No	0	0
464	1x27	1x31	lipid_on	0	4.16667	No	No	No	No	0	2
465	7x27	7x28	lipid_on	0	5.55556	No	No	No	No	1	3
466	5x79	5x80	lipid_on	0	0	No	No	No	No	0	0
467	2x551	3x27	lipid_on	0	5.09259	No	No	No	No	0	5
468	5x69	5x73	lipid_on	0	3.29861	No	No	No	No	5	0
469	8x55	8x58	lipid_on	0	2.77778	No	Yes	No	No	5	5
470	8x58	8x62	lipid_on	0	2.77778	No	No	No	No	5	0
471	8x60	8x63	lipid_on	0	1.38889	No	No	No	No	0	0
472	5x80	I3	lipid_on	0	0	No	No	No	Yes	0	3.4
473	1x65	1x66	lipid_on	0	0	No	No	No	No	0	0
474	1x61	1x62	lipid_on	0	2.77778	No	No	No	No	0	0
475	6x43	6x461	lipid_on	0	2.57937	No	No	No	No	6	0
476	2x68	E1x49	lipid_on	0	0	No	No	No	No	0	0
477	6x20	6x21	lipid_on	0	1.78571	No	No	No	No	0	0
478	6x20	6x23	lipid_on	0	0.595238	No	No	No	No	0	0
479	6x25	6x29	lipid_on	0	0.595238	No	No	No	No	3	6
480	3x49	R:R:L77	lipid_on	0	0.595238	Yes	Yes	No	No	9	0
481	6x22	6x26	lipid_on	0	0	No	No	No	No	0	5

Orange: nodes, hubs and links specific of lipid_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of lipid_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	lipid_off Avg Int. Strength	lipid_on Avg Int. Strength	lipid_off Num Of Links	lipid_on Num Of Links	ConSurf
1	1x59	lipid_off	0	0	4	3	5
2	2x39	lipid_off	13.3333	0	4	1	8
3	2x42	lipid_off	6.66667	0	5	3	8
4	3x25	lipid_off	20	16.6667	4	3	9
5	3x31	lipid_off	0	0	4	2	4
6	3x33	lipid_off	29.1667	0	4	2	6
7	3x50	lipid_off	57.5	0	6	3	9
8	5x51	lipid_off	0	25	5	3	6
9	5x65	lipid_off	0	0	4	1	8
10	6x58	lipid_off	20	16.6667	4	2	4
11	7x49	lipid_off	15	19.4444	5	3	9
12	8x49	lipid_off	0	0	4	2	6
13	8x59	lipid_off	0	0	4	2	0
14	E1x50	lipid_off	36.6667	24.4048	4	2	0
15	I4	lipid_off	10	0	5	2	0
16	NT	Shared	63.3333	34.7222	17	7	4
17	1x50	Shared	6.66667	8.73016	4	4	9
18	1x57	Shared	0	16.6667	5	4	7
19	2x40	Shared	20	16.6667	4	7	9
20	2x41	Shared	0	0	4	4	3
21	2x50	Shared	23.3333	48.1192	4	5	9
22	3x49	Shared	10	8.33333	4	4	9
23	3x51	Shared	20	8.33333	4	5	8
24	E2	Shared	100	100	24	23	4
25	5x58	Shared	15	68.0556	5	7	9
26	5x60	Shared	0	8.33333	4	4	4
27	6x48	Shared	73.3333	64.5833	5	6	8
28	E3	Shared	50	64.9802	9	8	1
29	7x53	Shared	20	59.7222	4	5	9
30	Lig	Shared	100	100	11	16	0
31	2x46	lipid_on	10	31.1632	2	4	9
32	2x51	lipid_on	0	0	3	4	7
33	2x57	lipid_on	10	20.1389	2	4	7
34	2x61	lipid_on	0	0	3	4	5
35	3x29	lipid_on	12.5	29.7743	3	4	4
36	3x56	lipid_on	0	0	3	4	5
37	I2x53	lipid_on	0	8.33333	1	4	7
38	6x30	lipid_on	0	0	1	5	7
39	6x32	lipid_on	0	0	2	4	7
40	6x44	lipid_on	20	20.8333	2	4	9
41	8x55	lipid_on	0	0	1	4	5
42	I3	lipid_on	0	16.6667	2	4	3.4

Orange: nodes, hubs and links specific of lipid_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of lipid_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	lipid_off Recurrence	lipid_on Recurrence	lipid_off Hub1?	lipid_on Hub1?	lipid_off Hub2?	lipid_on Hub2?	ConSurf1	ConSurf2
1	1x35	1x39	lipid_off	12.476	0	No	No	No	No	5	7
2	1x35	2x64	lipid_off	13.1031	0	No	No	No	No	5	4
3	6x48	7x41	lipid_off	99.7206	1.45995	Yes	Yes	No	No	8	7
4	6x51	7x41	lipid_off	99.8635	0	No	No	No	No	7	7
5	6x51	6x55	lipid_off	100	2.91554	No	No	No	No	7	6
6	6x55	Lig	lipid_off	69.5247	0	No	No	Yes	Yes	6	0
7	Lig	NT	lipid_off	20.2281	0	Yes	Yes	Yes	Yes	0	4
8	7x49	7x53	lipid_off	33.3734	0	Yes	No	Yes	Yes	9	9
9	2x42	4x42	lipid_off	12.0472	0	Yes	No	No	No	8	7
10	3x46	6x37	lipid_off	32.3272	0	No	No	No	No	9	8
11	5x58	6x37	lipid_off	34.0914	0.801883	Yes	Yes	No	No	9	8
12	3x47	5x58	lipid_off	40.3132	2.91554	No	No	Yes	Yes	8	9
13	3x47	5x54	lipid_off	41.2684	1.45995	No	No	No	No	8	8
14	5x54	6x41	lipid_off	63.1275	0	No	No	No	No	8	8
15	3x43	6x41	lipid_off	63.8877	0	No	No	No	No	8	8
16	3x43	6x44	lipid_off	64.6415	0	No	No	No	Yes	8	9
17	3x33	Lig	lipid_off	12.7944	9.45699	Yes	No	Yes	Yes	6	0
18	3x44	5x54	lipid_off	28.2498	0	No	No	No	No	7	8
19	3x51	5x57	lipid_off	17.1286	1.45995	Yes	Yes	No	No	8	7
20	5x53	5x57	lipid_off	18.2397	0	No	No	No	No	6	7
21	3x44	5x53	lipid_off	19.3639	1.45995	No	No	No	No	7	6
22	5x40	E2	lipid_off	30.3746	0	No	No	Yes	Yes	5	4
23	5x51	6x49	lipid_off	15.8842	0	Yes	No	No	No	6	5
24	6x49	6x50	lipid_off	17.4372	2.81095	No	No	No	No	5	9
25	6x50	7x37	lipid_off	18.9837	5.59139	No	No	No	No	9	5
26	6x54	7x37	lipid_off	20.5237	6.96853	No	No	No	No	4	5
27	6x54	7x34	lipid_off	25.1048	0	No	No	No	No	4	4
28	7x34	E2	lipid_off	25.7676	0.117668	No	No	Yes	Yes	4	4
29	2x40	I1x50	lipid_off	11.0238	7.30846	Yes	Yes	No	No	9	9
30	1x45	1x49	lipid_off	12.3103	0	No	No	No	No	4	8
31	7x26	E3	lipid_off	10.8353	0	No	No	Yes	Yes	0	1
32	2x64	Lig	lipid_off	10.3772	0.801883	No	No	Yes	Yes	4	0
33	5x40	6x55	lipid_off	32.0088	1.45995	No	No	No	No	5	6
34	1x49	7x50	Shared	14.6951	14.7869	No	No	No	No	8	9
35	1x50	7x50	Shared	15.8777	16.1117	Yes	Yes	No	No	9	9
36	1x50	2x50	Shared	25.1048	31.3301	Yes	Yes	Yes	Yes	9	9
37	2x50	7x49	Shared	28.4577	20.8751	Yes	Yes	Yes	No	9	9
38	7x45	7x49	Shared	68.8067	100	No	No	Yes	No	9	9
39	6x48	7x45	Shared	71.3474	99.8867	Yes	Yes	No	No	8	9
40	1x57	2x43	Shared	29.7735	46.823	Yes	Yes	No	No	7	8
41	2x43	7x53	Shared	30.4331	47.8253	No	No	Yes	Yes	8	9
42	1x57	2x40	Shared	25.7578	42.3255	Yes	Yes	Yes	Yes	7	9
43	2x42	3x46	Shared	31.2941	27.8436	Yes	No	No	No	8	9
44	6x44	6x48	Shared	65.3887	20.9318	No	Yes	Yes	Yes	9	8
45	2x46	3x42	Shared	12.9861	23.7035	No	Yes	No	No	9	8
46	2x46	7x49	Shared	14.1753	79.1641	No	Yes	Yes	No	9	9
47	2x42	3x49	Shared	17.9213	24.6317	Yes	No	Yes	Yes	8	9
48	2x40	8x49	Shared	11.5566	24.6753	Yes	Yes	Yes	No	9	6
49	E2	Lig	Shared	35.3715	52.2488	Yes	Yes	Yes	Yes	4	0
50	E2	E3	Shared	14.1005	19.1755	Yes	Yes	Yes	Yes	4	1
51	2x57	2x61	lipid_on	0	12.8606	No	Yes	No	Yes	7	5
52	2x57	Lig	lipid_on	0	21.4155	No	Yes	Yes	Yes	7	0
53	6x48	Lig	lipid_on	0	95.4328	Yes	Yes	Yes	Yes	8	0
54	3x43	7x53	lipid_on	0	90.068	No	No	Yes	Yes	8	9
55	2x46	3x43	lipid_on	0	90.5604	No	Yes	No	No	9	8
56	2x38	I2x57	lipid_on	0	17.2318	No	No	No	No	5	6
57	I2x53	I2x57	lipid_on	0.708275	17.9552	No	Yes	No	No	7	6
58	3x49	I2x53	lipid_on	0	21.3022	Yes	Yes	No	Yes	9	7
59	3x46	7x53	lipid_on	0	25.8607	No	No	Yes	Yes	9	9
60	2x45	3x42	lipid_on	6.94305	12.8606	No	No	No	No	9	8
61	2x45	4x50	lipid_on	4.99366	10.0628	No	No	No	No	9	9
62	3x42	4x49	lipid_on	5.00016	10.0628	No	No	No	No	8	6
63	3x50	5x58	lipid_on	0	35.9888	Yes	No	Yes	Yes	9	9
64	3x50	7x53	lipid_on	0	33.4612	Yes	No	Yes	Yes	9	9
65	3x51	5x58	lipid_on	0	29.6261	Yes	Yes	Yes	Yes	8	9
66	3x51	3x55	lipid_on	1.5725	11.4661	Yes	Yes	No	No	8	6
67	3x51	5x60	lipid_on	7.46288	12.6297	Yes	Yes	Yes	Yes	8	4
68	3x55	3x56	lipid_on	1.53676	10.0628	No	No	No	Yes	6	5
69	2x41	4x42	lipid_on	6.37773	14.5341	Yes	Yes	No	No	3	7
70	2x38	4x42	lipid_on	5.15286	15.9113	No	No	No	No	5	7
71	5x51	6x44	lipid_on	0	12.8606	Yes	No	No	Yes	6	9
72	7x33	E3	lipid_on	0	11.7711	No	No	Yes	Yes	4	1
73	1x49	7x51	lipid_on	1.25735	13.4533	No	No	No	No	8	6
74	7x51	7x55	lipid_on	0	12.111	No	No	No	No	6	5
75	6x31	6x32	lipid_on	0	17.7591	No	No	No	Yes	5	7
76	6x32	8x48	lipid_on	6.80984	23.1413	No	Yes	No	No	7	5
77	8x48	8x49	lipid_on	0	23.9083	No	No	Yes	No	5	6
78	E1x50	E1x52	lipid_on	6.82933	12.8999	Yes	No	No	No	0	0
79	E1x50	E2x50	lipid_on	0.00974691	14.3293	Yes	No	No	No	0	0
80	3x25	E2x50	lipid_on	1.36457	20.0471	Yes	No	No	No	9	0
81	3x25	E2	lipid_on	7.073	11.514	Yes	No	Yes	Yes	9	4
82	6x30	6x31	lipid_on	0	15.153	No	Yes	No	No	7	5
83	3x29	Lig	lipid_on	0.951948	11.697	No	Yes	Yes	Yes	4	0
84	3x25	3x29	lipid_on	0	10.407	Yes	No	No	Yes	9	4
85	2x46	2x50	lipid_on	0	17.5891	No	Yes	Yes	Yes	9	9

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
NT	NT	Shared	29.4018	13.6322	1	1	1	1
E1	NT	lipid_off	4.74067	0	1	0	2	1
E2	NT	Shared	30.447	14.9299	1	1	1	1
2x64	NT	lipid_off	3.7345	0	1	0	1	1
3x25	NT	lipid_off	4.95708	0	1	1	2	1
Lig	NT	lipid_off	5.2115	0	1	1	0	1
7x31	NT	Shared	3.78633	1.68236	1	0	2	1
1x35	1x39	lipid_off	4.01233	0	0	0	2	2
1x43	2x57	Shared	4.01358	3.33746	0	0	2	1
2x57	7x42	Shared	5.39917	3.87689	0	0	1	2
2x60	3x28	Shared	3.74258	5.10163	0	0	1	2
2x60	Lig	Shared	10.3401	5.84559	0	0	1	0
3x22	3x26	Shared	4.43183	3.35967	1	1	2	2
3x22	E2	Shared	6.86992	7.18414	1	1	2	1
3x25	E2	Shared	11.7869	6.33792	1	1	2	1
3x26	E2	Shared	6.59817	4.14295	1	1	2	1
3x29	E2	Shared	4.82067	4.36148	1	1	1	1
3x29	Lig	Shared	6.67792	3.36143	1	1	1	0
3x32	Lig	Shared	9.75017	3.32121	0	0	1	0
3x33	5x43	lipid_off	4.214	0	0	0	1	1
3x33	Lig	Shared	6.89208	6.95395	0	0	1	0
3x36	6x48	Shared	8.56717	3.36848	0	1	1	1
3x37	5x43	Shared	4.2415	2.66781	0	0	2	1
4x60	E2	Shared	4.58975	4.86688	1	1	2	1
4x60	5x39	Shared	9.07967	5.76654	1	1	2	2
E2	E2	Shared	64.987	44.8952	1	1	1	1
5x36	E2	Shared	13.0221	9.04495	1	1	2	1
5x39	E2	Shared	8.06383	5.94033	1	1	2	1
6x58	E2	Shared	10.0083	5.61622	1	1	2	1
E2	E3	Shared	4.19283	3.98307	1	1	1	2
7x34	E2	Shared	5.39375	5.53167	1	1	1	1
E2	Lig	Shared	8.4995	8.03631	1	1	1	0
5x40	E2	lipid_off	3.75242	0	1	0	2	1
6x48	7x41	Shared	6.3575	5.00615	0	1	1	2
6x48	7x45	Shared	5.77992	6.8272	0	1	1	2
6x51	6x55	Shared	5.644	4.83129	0	0	1	1
6x54	7x34	lipid_off	3.85975	0	0	0	2	1
7x38	Lig	Shared	10.6618	9.18513	0	0	1	0
7x39	Lig	lipid_off	3.96867	0	0	0	1	0
6x44	6x48	Shared	7.29325	3.27281	0	0	2	1
2x64	Lig	Shared	4.438	4.85215	1	0	1	0
3x40	6x48	Shared	4.344	4.98359	0	0	2	1
5x40	6x55	Shared	4.27375	3.24478	1	0	2	1
6x55	Lig	lipid_off	4.218	0	0	0	1	0
1x35	2x64	lipid_off	7.695	0	0	0	2	1
E1x49	E2	Shared	4.571	1.21551	1	1	2	1
3x29	4x65	Shared	3.85667	2.99351	1	1	1	2
E2	E2x51	Shared	4.36067	4.17184	1	1	1	2
E2	E2x52	Shared	4.02467	5.59631	1	1	1	1
6x58	7x31	lipid_off	4.90225	0	1	1	2	2
6x58	7x34	lipid_off	8.981	0	1	1	2	1
E3	E3	Shared	6.61133	6.67744	1	1	2	2
E3	NT	lipid_off	4.07467	0	1	1	2	1
7x27	NT	lipid_off	3.87767	0	1	1	2	1
E1x501	NT	Shared	3.67175	1.42712	0	0	2	1
1x39	7x42	lipid_off	3.58225	0	0	0	2	2
7x28	NT	lipid_off	3.41533	0	1	0	2	1
6x51	7x41	lipid_off	3.40933	0	0	0	1	2
5x38	E2	Shared	3.29967	3.3464	0	0	2	1
1x39	2x61	Shared	3.17508	2.85295	0	0	2	2
1x32	NT	Shared	2.85642	1.12855	1	0	2	1
7x35	Lig	Shared	2.75667	3.01475	0	0	1	0
1x46	2x54	Shared	2.74183	2.6356	0	0	2	1
3x33	4x57	Shared	2.577	2.3411	0	0	1	2
1x38	7x39	Shared	2.57375	3.57435	0	0	2	1
4x64	E2	Shared	2.49367	4.39089	0	0	2	1
2x53	3x32	lipid_off	2.36967	0	0	0	2	1
5x35	E2	Shared	2.093	1.81388	1	0	2	1
3x33	4x61	lipid_off	2.06	0	0	0	1	2
E1x48	NT	Shared	1.723	1.035	1	1	2	1
2x56	3x32	Shared	1.58267	2.95307	0	0	2	1
5x34	E2	Shared	1.284	2.13685	0	0	2	1
1x33	NT	lipid_off	0.464	0	0	0	2	1
6x64	E2	lipid_off	0.349	0	0	0	2	1
5x31	E2	lipid_off	0.219333	0	0	0	2	1
5x28	NT	lipid_off	0.192	0	0	0	2	1
7x24	NT	lipid_off	0.153	0	0	0	2	1
3x36	Lig	lipid_on	0	3.69164	0	1	1	0
5x43	Lig	lipid_on	0	4.96755	0	0	1	0
6x51	Lig	lipid_on	0	3.06115	0	0	1	0
7x34	Lig	lipid_on	0	4.92374	1	1	1	0
3x25	3x29	lipid_on	0	4.52293	1	1	2	1
6x48	Lig	lipid_on	0	3.78242	0	1	1	0
1x35	7x35	lipid_on	0	3.85776	0	0	2	1
4x65	E2x52	lipid_on	0	3.18536	0	0	2	1
E2x52	Lig	lipid_on	0	3.62214	0	1	1	0
2x57	Lig	lipid_on	0	2.96308	0	0	1	0
3x26	4x61	lipid_on	0	2.79637	1	1	2	2
5x37	E2	lipid_on	0	2.72424	0	1	2	1
4x63	E2	lipid_on	0	2.72064	0	0	2	1
2x57	2x61	lipid_on	0	2.62721	0	0	1	2
1x39	7x39	lipid_on	0	2.41149	0	0	2	1
2x54	Lig	lipid_on	0	2.38162	0	0	1	0
7x27	E3	lipid_on	0	0.634722	1	1	2	2
6x64	E3	lipid_on	0	0.273333	0	0	2	2
7x27	7x28	lipid_on	0	0.255694	1	1	2	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	lipid_off	cannabinoid_off leuko_off lpl_off paf_off prostanoid_off
	lipid_on	cannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on

Network Difference
Value	lipid_off	lipid_on
I_min	3.69225	2.9645
Number of Linked Nodes	309	324
Number of Specific Nodes	11 (3.56%)	26 (8.02%)
Number of Shared Nodes	298 (96.44%)	298 (91.98%)
Number of Links	326	336
Number of Specific Links	145 (44.48%)	155 (46.13%)
Number of Shared Links	181 (55.52%)	181 (53.87%)
Number of Hubs	30	27
Number of Specific Hubs	15 (50.00%)	12 (44.44%)
Number of Shared Hubs	15 (50.00%)	15 (55.56%)
Average % Shared Neighbours (Jaccard)	39.87
Average % Shared Neighbours (Otsuka)	48.23
Average % Shared Neighbours (Overlap Coefficient)	57.38
Average % Shared Cliques (k3-6)	79.69
Graphlets Similarity	0.477702

Paths Difference
Value	lipid_off	lipid_on
Number Of Nodes in MetaPath	50	51
Specific Nodes in MetaPath	24 (48.00%)	25 (49.02%)
Shared Nodes in MetaPath	298 (96.44%)	298 (96.44%)
Number Of Links MetaPath	50	52
Specific Links in MetaPath	33 (66.00%)	35 (67.31%)
Shared Links in MetaPath	181 (55.52%)	181 (55.52%)
Number of Shortest Paths	51918	44209
Length Of Smallest Path	3	3
Average Path Length	14.5548	12.7097
Length of Longest Path	31	29
Minimum Path Strength	0.431583	0.603239
Average Path Strength	4.48074	3.84722
Maximum Path Strength	21.7345	11.9874
Minimum Path Correlation	0.702333	0.700511
Average Path Correlation	0.892255	0.897041
Maximum Path Correlation	0.98625	0.987743
Minimum % Of Corr. Nodes	3.7037	3.84615
Average % Of Corr. Nodes	37.2636	38.6965
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	31.6898	39.2208
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

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