psnGPCR

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Orange: nodes, hubs and links specific of m1_on network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of m1_off network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	m1_on Int. Strength	m1_off Int. Strength	m1_on Hub1?	m1_off Hub1?	m1_on Hub2?	m1_off Hub2?	ConSurf1	ConSurf2
1	1x29	1x31	m1_on	7.9	0	No	No	No	No	2	6
2	1x30	1x31	m1_on	12.05	0	No	No	No	No	4	6
3	1x42	7x39	m1_on	3.42	0	No	No	Yes	No	7	8
4	1x46	1x50	m1_on	4.39	0	No	No	Yes	Yes	8	9
5	1x52	8x57	m1_on	4.15	0	No	No	No	No	8	8
6	I1x48	I1x49	m1_on	4.23	0	No	No	No	No	7	7
7	CT.K439	I1x48	m1_on	7.51	0	No	No	No	No	5	7
8	CT.W442	I1x49	m1_on	4.36	0	No	No	No	No	4	7
9	2x38	2x41	m1_on	3.79	0	Yes	No	No	No	7	7
10	2x40	2x43	m1_on	5.49	0	No	No	No	No	9	9
11	2x45	4x46	m1_on	7.74	0	No	No	No	No	9	9
12	2x46	3x43	m1_on	5.54	0	No	No	Yes	No	9	8
13	2x46	7x49	m1_on	10.98	0	No	No	No	No	9	9
14	2x46	7x53	m1_on	3.52	0	No	No	Yes	No	9	9
15	2x52	2x551	m1_on	3.77	0	No	No	No	No	8	6
16	2x53	3x36	m1_on	4.64	0	No	Yes	No	No	8	8
17	2x57	7x39	m1_on	8.14	0	No	Yes	Yes	No	8	8
18	2x60	7x39	m1_on	4.82	0	Yes	Yes	Yes	No	7	8
19	2x63	2x64	m1_on	3.52	0	Yes	No	No	No	7	7
20	2x63	E2x50	m1_on	4.03	0	Yes	No	No	No	7	9
21	3x25	3x26	m1_on	4.67	0	No	No	No	No	9	7
22	3x33	6x51	m1_on	7.94	0	Yes	Yes	Yes	No	8	8
23	3x34	4x53	m1_on	4.85	0	No	No	No	No	8	8
24	3x37	3x41	m1_on	5.44	0	Yes	Yes	No	No	8	7
25	3x40	6x44	m1_on	3.93	0	No	No	Yes	Yes	9	9
26	3x40	Lig	m1_on	5.31	0	No	No	Yes	Yes	9	0
27	3x43	7x49	m1_on	5.49	0	Yes	No	No	No	8	9
28	3x43	7x53	m1_on	4.69	0	Yes	No	Yes	No	8	9
29	3x44	3x48	m1_on	3.65	0	No	No	No	No	7	7
30	3x46	3x50	m1_on	5.01	0	No	No	No	Yes	9	9
31	3x46	7x53	m1_on	3.63	0	No	No	Yes	No	9	9
32	3x47	5x57	m1_on	4.5	0	No	No	No	No	9	8
33	3x47	5x58	m1_on	3.82	0	No	No	Yes	No	9	9
34	3x50	7x53	m1_on	9.26	0	No	Yes	Yes	No	9	9
35	I2x52	I2x56	m1_on	6.12	0	No	No	No	No	7	6
36	4x38	4x41	m1_on	6.47	0	No	No	No	No	8	8
37	4x40	4x44	m1_on	7.29	0	No	No	No	No	6	2
38	4x57	5x43	m1_on	4.85	0	Yes	Yes	No	No	8	8
39	4x64	5x36	m1_on	8.76	0	Yes	No	No	No	7	7
40	E2.E170	E2.T172	m1_on	11.29	0	No	No	No	No	4	4
41	E2.E170	E2.Q181	m1_on	7.65	0	No	No	No	No	4	8
42	5x39	E2.F182	m1_on	5.02	0	No	No	Yes	Yes	8	6
43	5x40	6x59	m1_on	4.71	0	No	No	No	No	7	8
44	5x42	5x45	m1_on	3.49	0	No	No	No	No	6	6
45	5x47	5x48	m1_on	11.35	0	Yes	Yes	Yes	No	9	7
46	5x47	6x49	m1_on	3.89	0	Yes	Yes	Yes	No	9	7
47	5x47	Lig	m1_on	5.21	0	Yes	Yes	Yes	Yes	9	0
48	5x48	6x56	m1_on	3.52	0	Yes	No	No	No	7	7
49	5x51	6x44	m1_on	3.93	0	No	No	Yes	Yes	7	9
50	5x55	6x41	m1_on	6.35	0	No	No	No	No	5	7
51	5x58	6x37	m1_on	7.03	0	Yes	No	No	No	9	9
52	5x58	6x40	m1_on	7.25	0	Yes	No	Yes	No	9	8
53	5x58	6x41	m1_on	10.55	0	Yes	No	No	No	9	7
54	5x58	7x53	m1_on	4.96	0	Yes	No	Yes	No	9	9
55	5x59	5x63	m1_on	7	0	No	No	No	No	4	5
56	5x62	5x66	m1_on	13.47	0	Yes	No	No	No	7	7
57	5x62	6x34	m1_on	6.67	0	Yes	No	No	No	7	8
58	5x62	6x37	m1_on	3.52	0	Yes	No	No	No	7	9
59	5x65	5x66	m1_on	4.23	0	No	No	No	No	8	7
60	5x66	6x31	m1_on	10.8	0	No	No	No	No	7	7
61	5x68	5x72	m1_on	4.86	0	No	Yes	No	No	8	4
62	6x40	7x53	m1_on	6.04	0	Yes	No	Yes	No	8	9
63	6x51	6x52	m1_on	8.14	0	Yes	No	No	No	8	8
64	6x51	6x55	m1_on	6.31	0	Yes	No	No	No	8	8
65	7x39	7x42	m1_on	18.33	0	Yes	No	Yes	Yes	8	8
66	7x55	8x54	m1_on	4.87	0	No	No	No	Yes	7	9
67	8x53	CT.W437	m1_on	3.64	0	No	No	Yes	No	8	3
68	8x58	CT.R436	m1_on	6.07	0	No	No	No	No	8	4
69	CT.W437	CT.W442	m1_on	3.75	0	Yes	No	No	No	3	4
70	CT.D438	CT.R440	m1_on	3.57	0	No	No	No	No	4	6
71	CT.R441	CT.R443	m1_on	6.4	0	No	No	No	No	8	5
72	2x37	2x38	m1_on	3.17	0	No	No	Yes	No	8	7
73	6x47	7x43	m1_on	3.17	0	No	Yes	No	No	8	7
74	1x54	2x47	m1_on	3.15	0	No	No	No	No	7	9
75	8x47	8x49	m1_on	3.13	0	No	No	No	No	9	7
76	3x41	4x52	m1_on	3.04	0	No	No	No	No	7	5
77	4x48	4x52	m1_on	2.98	0	No	No	No	No	4	5
78	1x44	1x48	m1_on	2.95	0	No	No	Yes	No	5	5
79	2x50	3x39	m1_on	2.94	0	Yes	Yes	No	No	9	9
80	5x36	E2.S184	m1_on	2.89	0	No	No	No	No	7	6
81	7x34	7x38	m1_on	2.89	0	Yes	Yes	Yes	Yes	7	7
82	3x54	5x64	m1_on	2.85	0	No	No	No	No	8	7
83	5x61	6x37	m1_on	2.85	0	No	No	No	No	9	9
84	6x54	7x33	m1_on	2.83	0	No	No	No	No	6	5
85	7x51	7x55	m1_on	2.83	0	No	No	No	No	6	7
86	7x32	7x35	m1_on	2.82	0	No	No	No	No	4	6
87	4x42	I2x57	m1_on	2.77	0	No	No	Yes	Yes	8	8
88	5x62	6x33	m1_on	2.67	0	Yes	No	No	No	7	9
89	3x37	4x56	m1_on	2.66	0	Yes	Yes	No	No	8	8
90	5x40	E2.F182	m1_on	2.59	0	No	No	Yes	Yes	7	6
91	5x56	5x60	m1_on	2.59	0	No	No	No	No	5	7
92	3x21	3x24	m1_on	1.95	0	No	No	No	No	7	6
93	E2.A175	E2.G176	m1_on	1.95	0	No	No	No	No	3	2
94	1x39	1x40	m1_on	1.82	0	Yes	Yes	No	No	6	5
95	1x48	1x49	m1_on	1.82	0	Yes	No	No	No	5	9
96	1x35	1x36	m1_on	1.76	0	No	No	No	No	7	5
97	5x37	6x59	m1_on	1.75	0	No	No	No	No	5	8
98	1x53	7x54	m1_on	1.7	0	No	No	No	No	9	8
99	CT.I445	CT.P446	m1_on	1.69	0	No	No	No	No	7	8
100	7x48	7x52	m1_on	1.64	0	No	No	No	No	6	8
101	3x53	3x54	m1_on	1.62	0	No	No	No	No	9	8
102	1x47	1x48	m1_on	1.59	0	No	No	Yes	No	7	5
103	E1x49	E2.G176	m1_on	1.59	0	No	No	No	No	5	2
104	5x52	5x56	m1_on	1.57	0	No	No	No	No	5	5
105	1x55	1x59	m1_on	1.54	0	No	No	No	No	6	7
106	6x36	6x40	m1_on	1.52	0	No	No	Yes	No	8	8
107	1x47	1x51	m1_on	1.49	0	No	No	No	No	7	5
108	4x67	4x68	m1_on	1.49	0	No	No	Yes	No	4	4
109	2x59	2x62	m1_on	1.47	0	No	No	No	No	7	7
110	7x32	7x36	m1_on	1.47	0	No	No	No	No	4	5
111	3x56	I2x50	m1_on	1.44	0	No	Yes	No	No	7	8
112	1x31	1x32	m1_on	1.43	0	No	No	No	No	6	4
113	1x37	1x41	m1_on	1.43	0	No	No	No	No	4	5
114	3x45	4x45	m1_on	1.41	0	No	No	No	No	7	7
115	4x40	4x43	m1_on	1.38	0	No	No	No	No	6	5
116	5x44	5x48	m1_on	1.33	0	No	No	Yes	No	7	7
117	5x67	5x71	m1_on	1.31	0	No	No	No	No	5	5
118	CT.D438	CT.R441	m1_on	1.19	0	No	No	No	No	4	8
119	1x39	2x61	Shared	7.85	10.99	Yes	Yes	No	No	6	8
120	1x39	7x39	Shared	7.28	8.49	Yes	Yes	Yes	No	6	8
121	1x40	1x43	Shared	3.71	1.86	No	No	No	No	5	7
122	1x43	2x58	Shared	7.45	8.94	No	No	No	No	7	9
123	1x46	2x54	Shared	5.46	3.64	No	No	No	No	8	8
124	1x46	7x47	Shared	6.28	9.42	No	No	No	No	8	8
125	1x50	2x50	Shared	6.73	6.73	Yes	Yes	Yes	Yes	9	9
126	1x50	7x50	Shared	8.15	13.03	Yes	Yes	No	No	9	9
127	1x52	8x54	Shared	7.31	13.4	No	No	No	Yes	8	9
128	1x56	8x50	Shared	6.61	3.96	No	No	Yes	Yes	9	9
129	1x57	I1x51	Shared	4.96	6.2	No	No	No	No	8	7
130	1x57	2x41	Shared	5.16	4.13	No	No	No	No	8	7
131	1x57	2x44	Shared	9.74	13.4	No	No	No	No	8	7
132	1x59	CT.W437	Shared	8.58	14.71	No	No	Yes	No	7	3
133	1x60	I1x49	Shared	10.52	6.57	Yes	Yes	No	No	8	7
134	1x60	I1x50	Shared	9.61	6.87	Yes	Yes	No	No	8	9
135	1x60	8x53	Shared	5.85	8.77	Yes	Yes	No	No	8	8
136	1x60	CT.W437	Shared	9.04	7.91	Yes	Yes	Yes	No	8	3
137	8x50	I1x50	Shared	6.09	13.4	Yes	Yes	No	No	9	9
138	2x38	I2x57	Shared	6.54	9.15	Yes	No	Yes	Yes	7	8
139	2x38	4x39	Shared	3.53	3.53	Yes	No	No	No	7	5
140	2x39	I2x57	Shared	9.64	7.23	No	No	Yes	Yes	8	8
141	2x40	8x50	Shared	12.08	7.25	No	No	Yes	Yes	9	9
142	2x42	3x45	Shared	6.09	7.31	No	Yes	No	No	8	7
143	2x42	3x49	Shared	13.14	7.17	No	Yes	No	No	8	9
144	2x42	4x46	Shared	6.28	6.28	No	Yes	No	No	8	9
145	2x45	3x42	Shared	4.47	7.45	No	No	No	No	9	8
146	2x50	7x46	Shared	7.36	8.83	Yes	Yes	No	No	9	9
147	2x50	7x49	Shared	8.08	8.08	Yes	Yes	No	No	9	9
148	2x52	3x31	Shared	4.28	4.28	No	No	No	No	8	6
149	2x52	3x35	Shared	4.87	3.25	No	No	No	No	8	7
150	2x53	7x46	Shared	9.29	7.74	No	Yes	No	No	8	9
151	2x55	2x551	Shared	3.89	14.27	No	No	No	No	5	6
152	2x551	3x31	Shared	3.65	4.87	No	No	No	No	6	6
153	2x56	3x32	Shared	10.31	11.78	No	No	No	Yes	8	9
154	2x56	7x42	Shared	3.82	3.82	No	No	Yes	Yes	8	8
155	2x57	7x42	Shared	11.97	13.17	No	Yes	Yes	Yes	8	8
156	2x59	3x28	Shared	7.97	10.25	No	No	Yes	Yes	7	7
157	2x60	2x64	Shared	9.38	3.52	Yes	Yes	No	No	7	7
158	2x60	3x28	Shared	3.86	6.75	Yes	Yes	Yes	Yes	7	7
159	2x60	7x38	Shared	11.91	19.86	Yes	Yes	Yes	Yes	7	7
160	2x60	7x42	Shared	6.95	7.94	Yes	Yes	Yes	Yes	7	8
161	2x61	2x65	Shared	7.37	2.95	No	No	No	No	8	6
162	2x63	E1x50	Shared	8.68	7.72	Yes	No	Yes	Yes	7	9
163	2x64	7x35	Shared	9.28	6.63	No	No	No	No	7	6
164	E1x50	E1x52	Shared	4.56	5.69	Yes	Yes	No	No	9	7
165	3x25	E1x50	Shared	6.53	7.84	No	No	Yes	Yes	9	9
166	3x28	E1x50	Shared	4.69	9.37	Yes	Yes	Yes	Yes	7	9
167	E1x50	E2x50	Shared	11.75	7.84	Yes	Yes	No	No	9	9
168	3x22	E2.R171	Shared	9.06	10.35	No	No	Yes	Yes	4	7
169	3x25	E2x50	Shared	7.28	7.28	No	No	No	No	9	9
170	3x26	4x65	Shared	6.53	6.53	No	No	No	No	7	7
171	3x26	E2.R171	Shared	10.72	8.34	No	No	Yes	Yes	7	7
172	3x28	3x29	Shared	7.97	7.97	Yes	Yes	No	No	7	7
173	3x32	7x42	Shared	9.2	10.34	No	Yes	Yes	Yes	9	8
174	3x32	Lig	Shared	9.68	4.33	No	Yes	Yes	Yes	9	0
175	3x33	4x57	Shared	16.4	15.43	Yes	Yes	Yes	Yes	8	8
176	3x33	4x61	Shared	3.63	3.63	Yes	Yes	Yes	Yes	8	7
177	3x33	E2x52	Shared	7.25	8.46	Yes	Yes	Yes	Yes	8	7
178	3x33	7x38	Shared	6.95	4.96	Yes	Yes	Yes	Yes	8	7
179	3x33	Lig	Shared	13.38	20.96	Yes	Yes	Yes	Yes	8	0
180	3x36	6x48	Shared	3.71	6.18	No	No	Yes	Yes	8	8
181	3x36	Lig	Shared	11.78	9.59	No	No	Yes	Yes	8	0
182	3x37	4x53	Shared	5.78	5.78	Yes	Yes	No	No	8	8
183	3x37	4x57	Shared	8.76	8.76	Yes	Yes	Yes	Yes	8	8
184	3x37	5x461	Shared	4.55	4.55	Yes	Yes	No	No	8	8
185	3x37	Lig	Shared	10.44	5.1	Yes	Yes	Yes	Yes	8	0
186	3x38	4x50	Shared	7.78	9.08	No	No	No	Yes	8	9
187	3x38	4x53	Shared	3.42	3.42	No	No	No	No	8	8
188	3x40	6x48	Shared	4.9	3.68	No	No	Yes	Yes	9	8
189	3x42	4x50	Shared	6.78	4.52	No	No	No	Yes	8	9
190	3x43	5x54	Shared	4.24	5.65	Yes	No	No	No	8	9
191	3x43	6x44	Shared	4.87	8.53	Yes	No	Yes	Yes	8	9
192	3x47	5x54	Shared	4.6	6.13	No	No	No	No	9	9
193	3x48	5x57	Shared	8.53	7.31	No	No	No	No	7	8
194	3x49	I2x53	Shared	9.2	8.05	No	No	Yes	Yes	9	9
195	3x49	I2x57	Shared	9.53	13.1	No	No	Yes	Yes	9	8
196	3x50	5x58	Shared	6.17	2.06	No	Yes	Yes	No	9	9
197	3x51	3x55	Shared	16.23	16.23	No	Yes	No	No	8	8
198	3x51	5x57	Shared	15.24	3.52	No	Yes	No	No	8	8
199	3x51	5x60	Shared	7.2	2.06	No	Yes	No	No	8	7
200	3x52	I2x53	Shared	11.35	11.35	No	Yes	Yes	Yes	7	9
201	3x56	I2x52	Shared	6.59	2.64	No	Yes	No	No	7	7
202	I2x53	I2x57	Shared	19.55	8.23	Yes	Yes	Yes	Yes	9	8
203	4x38	4x39	Shared	3.5	3.5	No	No	No	No	8	5
204	4x54	4x58	Shared	4.16	8.32	No	No	No	No	6	6
205	4x57	4x61	Shared	3.52	3.52	Yes	Yes	Yes	Yes	8	7
206	4x57	Lig	Shared	7.31	8	Yes	Yes	Yes	Yes	8	0
207	4x61	E2x52	Shared	5.89	5.89	Yes	Yes	Yes	Yes	7	7
208	4x62	4x63	Shared	3.65	6.09	No	No	No	No	6	6
209	4x64	4x68	Shared	6.13	8.58	Yes	No	Yes	No	7	4
210	4x64	E2.Q181	Shared	12.05	5.48	Yes	No	No	No	7	8
211	4x64	E2.F182	Shared	11.02	10.02	Yes	No	Yes	Yes	7	6
212	4x65	4x66	Shared	6.76	13.53	No	No	No	No	7	5
213	4x65	E2.R171	Shared	7.01	10.51	No	No	Yes	Yes	7	7
214	4x68	E2.E170	Shared	8.56	1.43	Yes	No	No	No	4	4
215	E2.R171	E2.V173	Shared	6.54	7.85	Yes	Yes	No	No	7	4
216	E2.Q181	E2.T172	Shared	4.25	9.92	No	No	No	No	8	4
217	E2.V173	E2x51	Shared	10.09	16.4	No	No	No	No	4	4
218	E2.F182	E2x52	Shared	5.02	5.02	Yes	Yes	Yes	Yes	6	7
219	E2.L183	E2x52	Shared	7.14	7.14	No	Yes	Yes	Yes	7	7
220	5x41	5x45	Shared	4.98	7.46	No	Yes	No	No	7	6
221	5x41	6x56	Shared	4.87	7.31	No	Yes	No	No	7	7
222	5x45	5x48	Shared	5.99	4.79	No	No	Yes	No	6	7
223	5x47	5x51	Shared	7.87	7.87	Yes	Yes	No	No	9	7
224	5x47	6x48	Shared	6.01	7.02	Yes	Yes	Yes	Yes	9	8
225	5x47	6x52	Shared	25.37	22.96	Yes	Yes	No	No	9	8
226	5x48	6x52	Shared	3.49	5.81	Yes	No	No	No	7	8
227	5x54	6x44	Shared	7.46	3.73	No	No	Yes	Yes	9	9
228	6x44	6x48	Shared	8.02	17.04	Yes	Yes	Yes	Yes	9	8
229	6x45	6x49	Shared	4.56	3.04	No	No	Yes	No	7	7
230	6x47	6x48	Shared	3.64	3.64	No	Yes	Yes	Yes	8	8
231	6x47	7x45	Shared	7.31	5.85	No	Yes	No	No	8	9
232	6x48	7x41	Shared	16.98	11.75	Yes	Yes	No	No	8	8
233	6x48	7x45	Shared	10.17	7.91	Yes	Yes	No	No	8	9
234	6x48	Lig	Shared	16.25	10.91	Yes	Yes	Yes	Yes	8	0
235	6x49	6x50	Shared	5.25	3.5	Yes	No	No	No	7	9
236	6x50	7x40	Shared	4.93	4.93	No	No	No	No	9	8
237	6x51	7x38	Shared	3.97	7.94	Yes	No	Yes	Yes	8	7
238	6x51	Lig	Shared	8.36	14.22	Yes	No	Yes	Yes	8	0
239	6x54	7x34	Shared	4.65	8.14	No	No	Yes	Yes	6	7
240	6x59	6x60	Shared	3.89	9.08	No	No	No	No	8	5
241	6x61	E3.C394	Shared	7.28	7.28	No	No	No	No	6	8
242	7x30	E3.V395	Shared	3.53	3.53	No	No	No	Yes	6	6
243	7x31	7x34	Shared	4.36	3.27	No	No	Yes	Yes	3	7
244	7x38	Lig	Shared	10.03	16.47	Yes	Yes	Yes	Yes	7	0
245	7x41	Lig	Shared	4.53	6.08	No	No	Yes	Yes	8	0
246	7x42	Lig	Shared	5.85	4.49	Yes	Yes	Yes	Yes	8	0
247	8x47	8x50	Shared	8.46	7.25	No	No	Yes	Yes	9	9
248	8x56	CT.W437	Shared	5.69	3.42	No	No	Yes	No	6	3
249	1x53	2x47	Shared	3.39	3.39	No	No	No	No	9	9
250	2x63	E2.Q177	Shared	3.38	6.76	Yes	No	No	No	7	4
251	3x44	5x50	Shared	3.28	4.93	No	No	No	No	7	9
252	5x49	5x50	Shared	3.28	1.64	No	No	No	No	7	9
253	2x53	3x35	Shared	3.25	3.25	No	Yes	No	No	8	7
254	3x30	4x62	Shared	3.15	4.73	No	No	No	No	8	6
255	6x54	E3.V395	Shared	3.04	6.09	No	No	No	Yes	6	6
256	3x44	5x53	Shared	2.98	2.98	No	No	No	No	7	7
257	1x48	1x52	Shared	2.95	2.95	Yes	No	No	No	5	8
258	E1x49	E1x51	Shared	2.93	2.93	No	No	No	No	5	4
259	2x37	2x40	Shared	2.92	8.77	No	No	No	No	8	9
260	1x54	2x44	Shared	2.77	4.15	No	No	No	No	7	7
261	3x23	3x27	Shared	2.77	2.77	No	No	No	No	4	6
262	4x60	E2.F182	Shared	2.77	4.16	No	No	Yes	Yes	7	6
263	8x48	8x52	Shared	2.77	11.06	No	No	No	No	5	6
264	1x50	2x51	Shared	2.75	2.75	Yes	Yes	No	No	9	8
265	E2.L174	E2.Q177	Shared	2.66	3.99	No	No	No	No	3	4
266	5x64	5x67	Shared	2.63	5.26	No	No	No	No	7	5
267	1x53	8x54	Shared	2.62	3.93	No	No	No	Yes	9	9
268	3x34	4x54	Shared	2.62	5.24	No	No	No	No	8	6
269	2x49	4x50	Shared	2.59	2.59	No	No	No	Yes	9	9
270	3x24	E1x50	Shared	2.59	2.59	No	No	Yes	Yes	6	9
271	3x53	I2x53	Shared	2.54	3.82	No	No	Yes	Yes	9	9
272	6x58	7x34	Shared	2.47	4.94	No	No	Yes	Yes	5	7
273	4x58	4x59	Shared	1.87	1.87	No	No	No	No	6	8
274	4x68	4x69	Shared	1.84	1.84	Yes	No	No	No	4	4
275	1x36	1x39	Shared	1.82	1.82	No	No	Yes	Yes	5	6
276	6x36	7x56	Shared	1.69	1.69	No	No	No	No	8	8
277	1x45	7x47	Shared	1.68	1.68	No	No	No	No	5	8
278	6x40	7x52	Shared	1.64	4.91	Yes	No	No	No	8	8
279	3x30	4x61	Shared	1.62	3.25	No	No	Yes	Yes	8	7
280	6x43	7x48	Shared	1.62	4.87	No	No	No	No	7	6
281	3x41	4x49	Shared	1.61	3.22	No	No	No	No	7	8
282	1x54	2x48	Shared	1.59	3.17	No	No	No	No	7	6
283	6x49	6x53	Shared	1.52	3.04	Yes	No	No	No	7	7
284	3x27	4x62	Shared	1.38	1.38	No	No	No	No	6	6
285	E3.D393	E3.K392	Shared	1.38	2.77	No	No	No	No	4	4
286	4x54	4x55	Shared	1.31	1.31	No	No	No	No	6	5
287	4x38	4x40	Shared	1.29	9.06	No	No	No	No	8	6
288	8x48	8x51	Shared	1.24	1.24	No	No	No	No	5	9
289	5x43	Lig	m1_off	0	4.71	No	No	Yes	Yes	8	0
290	5x461	Lig	m1_off	0	4.02	No	No	Yes	Yes	8	0
291	6x52	Lig	m1_off	0	10.52	No	No	Yes	Yes	8	0
292	1x31	NT.K20	m1_off	0	6.78	No	No	No	Yes	6	0
293	2x64	NT.K20	m1_off	0	4.23	No	No	No	Yes	7	0
294	7x35	NT.K20	m1_off	0	4.05	No	No	No	Yes	6	0
295	1x28	1x29	m1_off	0	4.06	No	No	No	No	0	2
296	1x32	2x65	m1_off	0	7.45	No	No	No	No	4	6
297	1x34	1x38	m1_off	0	5.19	No	No	No	No	3	4
298	1x35	2x65	m1_off	0	7.14	No	No	No	No	7	6
299	1x42	2x57	m1_off	0	4.24	No	No	No	Yes	7	8
300	1x42	7x47	m1_off	0	5.9	No	No	No	No	7	8
301	1x46	2x57	m1_off	0	4.52	No	No	No	Yes	8	8
302	1x49	7x50	m1_off	0	4.06	No	No	No	No	9	9
303	1x50	2x47	m1_off	0	4.69	Yes	Yes	No	No	9	9
304	1x51	1x55	m1_off	0	4.28	No	No	No	No	5	6
305	1x52	8x58	m1_off	0	6.92	No	No	No	No	8	8
306	1x53	7x53	m1_off	0	6.31	No	No	Yes	No	9	9
307	1x55	8x57	m1_off	0	5.71	No	No	No	No	6	8
308	1x56	8x54	m1_off	0	5.28	No	No	No	Yes	9	9
309	I1x48	I1x51	m1_off	0	4.5	No	No	No	No	7	7
310	8x49	I1x49	m1_off	0	4.53	No	No	No	No	7	7
311	2x40	I1x50	m1_off	0	4.12	No	No	No	No	9	9
312	2x41	4x39	m1_off	0	5.56	No	No	No	No	7	5
313	2x42	3x46	m1_off	0	5.02	No	Yes	No	No	8	9
314	2x43	7x53	m1_off	0	21.1	No	No	Yes	No	9	9
315	2x45	4x50	m1_off	0	6.18	No	No	No	Yes	9	9
316	2x46	2x50	m1_off	0	4.07	No	No	Yes	Yes	9	9
317	2x53	2x54	m1_off	0	3.53	No	Yes	No	No	8	8
318	2x53	2x56	m1_off	0	7.74	No	Yes	No	No	8	8
319	2x53	7x42	m1_off	0	4.84	No	Yes	Yes	Yes	8	8
320	3x28	E2x50	m1_off	0	3.92	Yes	Yes	No	No	7	9
321	3x29	E2x52	m1_off	0	4.28	No	No	Yes	Yes	7	7
322	3x32	7x38	m1_off	0	4.6	No	Yes	Yes	Yes	9	7
323	3x37	3x40	m1_off	0	4.3	Yes	Yes	No	No	8	9
324	3x40	5x50	m1_off	0	3.53	No	No	No	No	9	9
325	3x43	6x41	m1_off	0	5.54	Yes	No	No	No	8	7
326	3x48	3x52	m1_off	0	5.36	No	No	No	Yes	7	7
327	3x50	5x61	m1_off	0	11.27	No	Yes	No	No	9	9
328	3x50	6x34	m1_off	0	4.15	No	Yes	No	No	9	8
329	3x50	6x37	m1_off	0	4.86	No	Yes	No	No	9	9
330	3x51	3x52	m1_off	0	6.19	No	Yes	No	Yes	8	7
331	3x51	3x56	m1_off	0	4.12	No	Yes	No	Yes	8	7
332	3x51	5x61	m1_off	0	4.84	No	Yes	No	No	8	9
333	3x52	3x56	m1_off	0	6.41	No	Yes	No	Yes	7	7
334	3x54	5x61	m1_off	0	4.61	No	No	No	No	8	9
335	3x54	5x68	m1_off	0	5.23	No	No	No	Yes	8	8
336	3x55	3x56	m1_off	0	10.35	No	No	No	Yes	8	7
337	3x55	5x64	m1_off	0	4.23	No	No	No	No	8	7
338	I2x53	I2x56	m1_off	0	3.58	Yes	Yes	No	No	9	6
339	I2x54	I2x57	m1_off	0	6.4	No	No	Yes	Yes	7	8
340	4x41	I2x56	m1_off	0	4.95	No	No	No	No	8	6
341	4x41	4x45	m1_off	0	3.72	No	No	No	No	8	7
342	4x44	4x48	m1_off	0	4.15	No	No	No	No	2	4
343	4x46	4x47	m1_off	0	3.53	No	No	No	No	9	4
344	E2.L174	E2x51	m1_off	0	3.52	No	No	No	No	3	4
345	E2.F182	E2.L183	m1_off	0	7.31	Yes	Yes	No	Yes	6	7
346	5x40	E2.L183	m1_off	0	7.37	No	No	No	Yes	7	7
347	5x43	E2.L183	m1_off	0	4.42	No	No	No	Yes	8	7
348	5x36	5x38	m1_off	0	6.86	No	No	No	No	7	5
349	5x36	5x39	m1_off	0	4.12	No	No	No	No	7	8
350	5x37	E3.K392	m1_off	0	10.04	No	No	No	No	5	4
351	5x41	6x55	m1_off	0	3.93	No	Yes	No	No	7	8
352	5x41	6x59	m1_off	0	5.19	No	Yes	No	No	7	8
353	5x47	6x44	m1_off	0	5.36	Yes	Yes	Yes	Yes	9	9
354	5x58	6x38	m1_off	0	5.09	Yes	No	No	No	9	7
355	5x65	5x68	m1_off	0	5.17	No	No	No	Yes	8	8
356	5x68	6x30	m1_off	0	12.79	No	Yes	No	No	8	9
357	6x25	6x27	m1_off	0	4.87	No	No	No	No	0	0
358	6x36	7x53	m1_off	0	4.99	No	No	Yes	No	8	9
359	6x37	6x41	m1_off	0	6.92	No	No	No	No	9	7
360	6x40	7x49	m1_off	0	7.08	Yes	No	No	No	8	9
361	6x44	7x45	m1_off	0	3.62	Yes	Yes	No	No	9	9
362	6x47	7x40	m1_off	0	4.42	No	Yes	No	No	8	8
363	6x51	7x34	m1_off	0	6.75	Yes	No	Yes	Yes	8	7
364	6x56	6x60	m1_off	0	4.87	No	No	No	No	7	5
365	7x33	E3.V395	m1_off	0	4.47	No	No	No	Yes	5	6
366	7x34	E3.V395	m1_off	0	9.81	Yes	Yes	No	Yes	7	6
367	7x30	7x33	m1_off	0	9.85	No	No	No	No	6	5
368	7x38	7x42	m1_off	0	6.95	Yes	Yes	Yes	Yes	7	8
369	7x54	8x54	m1_off	0	4.16	No	No	No	Yes	8	9
370	8x59	CT.R436	m1_off	0	14.58	No	No	No	No	5	4
371	6x54	7x37	m1_off	0	3.49	No	No	No	No	6	6
372	4x56	4x57	m1_off	0	3.42	No	No	Yes	Yes	8	8
373	1x28	1x31	m1_off	0	3.29	No	No	No	No	0	6
374	6x26	6x28	m1_off	0	3.23	No	No	No	No	0	0
375	5x60	5x63	m1_off	0	3.2	No	No	No	No	7	5
376	7x55	7x56	m1_off	0	3.17	No	No	No	No	7	8
377	5x36	5x37	m1_off	0	3.16	No	No	No	No	7	5
378	1x43	2x57	m1_off	0	3.07	No	No	No	Yes	7	8
379	3x41	4x53	m1_off	0	3.07	No	No	No	No	7	8
380	7x43	7x48	m1_off	0	3.07	No	No	No	No	7	6
381	1x32	NT.K20	m1_off	0	3.04	No	No	No	Yes	4	0
382	2x46	3x39	m1_off	0	3	No	No	No	No	9	9
383	1x42	7x43	m1_off	0	2.98	No	No	No	No	7	7
384	4x51	4x55	m1_off	0	2.98	No	No	No	No	4	5
385	4x52	4x56	m1_off	0	2.98	No	No	No	No	5	8
386	5x53	5x57	m1_off	0	2.98	No	No	No	No	7	8
387	5x49	5x52	m1_off	0	2.95	No	No	No	No	7	5
388	6x46	6x47	m1_off	0	2.95	No	No	No	Yes	5	8
389	8x53	8x57	m1_off	0	2.95	No	No	No	No	8	8
390	5x68	I2x50	m1_off	0	2.88	No	Yes	No	No	8	8
391	3x21	E1x50	m1_off	0	2.81	No	No	Yes	Yes	7	9
392	4x48	4x51	m1_off	0	2.77	No	No	No	No	4	4
393	6x42	6x46	m1_off	0	2.77	No	No	No	No	7	5
394	2x66	E1x49	m1_off	0	2.63	No	No	No	No	6	5
395	5x68	6x27	m1_off	0	2.43	No	Yes	No	No	8	0
396	8x55	8x56	m1_off	0	2.43	No	No	No	No	6	6
397	8x56	CT.R436	m1_off	0	2.43	No	No	No	No	6	4
398	5x44	Lig	m1_off	0	2.01	No	No	Yes	Yes	7	0
399	1x47	2x54	m1_off	0	1.84	No	No	No	No	7	8
400	6x39	7x52	m1_off	0	1.81	No	No	No	No	8	8
401	3x30	4x58	m1_off	0	1.79	No	No	No	No	8	6
402	5x37	6x58	m1_off	0	1.78	No	No	No	No	5	5
403	1x40	1x44	m1_off	0	1.71	No	No	No	No	5	5
404	5x51	5x55	m1_off	0	1.71	No	No	No	No	7	5
405	6x57	E3.C394	m1_off	0	1.71	No	No	No	No	6	8
406	7x36	7x37	m1_off	0	1.71	No	No	No	No	5	6
407	2x38	4x42	m1_off	0	1.7	Yes	No	No	No	7	8
408	E2.G176	E2.Q177	m1_off	0	1.64	No	No	No	No	2	4
409	1x38	1x39	m1_off	0	1.57	No	No	Yes	Yes	4	6
410	5x39	E2.S184	m1_off	0	1.55	No	No	No	No	8	6
411	6x53	6x57	m1_off	0	1.54	No	No	No	No	7	6
412	1x32	2x66	m1_off	0	1.52	No	No	No	No	4	6
413	2x62	2x66	m1_off	0	1.51	No	No	No	No	7	6
414	6x27	6x31	m1_off	0	1.41	No	No	No	No	0	7
415	8x47	8x48	m1_off	0	1.4	No	No	No	No	9	5
416	6x31	6x35	m1_off	0	1.24	No	No	No	No	7	7
417	5x58	5x59	m1_off	0	0.96	Yes	No	No	No	9	4

Orange: nodes, hubs and links specific of m1_on network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of m1_off network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	m1_on Avg Int. Strength	m1_off Avg Int. Strength	m1_on Num Of Links	m1_off Num Of Links	ConSurf
1	1x48	m1_on	2.3275	2.95	4	1	5
2	2x38	m1_on	4.2575	4.79333	4	3	7
3	2x63	m1_on	4.9025	7.24	4	2	7
4	3x43	m1_on	4.966	6.57333	5	3	8
5	4x64	m1_on	9.49	8.02667	4	3	7
6	4x68	m1_on	4.505	3.95	4	3	4
7	5x48	m1_on	5.136	5.3	5	2	7
8	5x58	m1_on	6.63	2.70333	6	3	9
9	5x62	m1_on	6.5825	0	4	0	7
10	6x40	m1_on	4.1125	5.995	4	2	8
11	6x49	m1_on	3.805	3.19333	4	3	7
12	6x51	m1_on	6.944	9.63667	5	3	8
13	7x39	m1_on	8.398	8.49	5	1	8
14	7x53	m1_on	5.35	10.8	6	3	9
15	CT.W437	m1_on	6.14	8.68	5	3	3
16	1x39	Shared	4.6925	5.7175	4	4	6
17	1x50	Shared	5.505	6.8	4	4	9
18	1x60	Shared	8.755	7.53	4	4	8
19	2x50	Shared	6.2775	6.9275	4	4	9
20	2x60	Shared	7.384	9.5175	5	4	7
21	E1x50	Shared	6.46667	6.26571	6	7	9
22	3x28	Shared	6.1225	7.652	4	5	7
23	3x33	Shared	9.25833	10.688	6	5	8
24	3x37	Shared	6.27167	5.698	6	5	8
25	I2x53	Shared	10.66	7.006	4	5	9
26	I2x57	Shared	9.606	8.822	5	5	8
27	4x57	Shared	8.168	7.826	5	5	8
28	4x61	Shared	3.665	4.0725	4	4	7
29	E2.R171	Shared	8.3325	9.2625	4	4	7
30	E2x52	Shared	6.325	6.158	4	5	7
31	E2.F182	Shared	5.284	6.6275	5	4	6
32	5x47	Shared	9.95	10.8025	6	4	9
33	6x44	Shared	5.642	7.656	5	5	9
34	6x48	Shared	8.71	8.51625	8	8	8
35	7x34	Shared	3.5925	6.582	4	5	7
36	7x38	Shared	7.15	10.13	5	6	7
37	7x42	Shared	9.35333	7.36429	6	7	8
38	8x50	Shared	8.31	7.965	4	4	9
39	Lig	Shared	9.01083	8.67214	12	14	0
40	NT.K20	m1_off	0	4.525	0	4	0
41	2x42	m1_off	8.50333	6.445	3	4	8
42	2x53	m1_off	5.72667	5.42	3	5	8
43	2x57	m1_off	10.055	6.25	2	4	8
44	3x32	m1_off	9.73	7.7625	3	4	9
45	3x50	m1_off	6.81333	5.585	3	4	9
46	3x51	m1_off	12.89	6.16	3	6	8
47	3x52	m1_off	11.35	7.3275	1	4	7
48	3x56	m1_off	4.015	5.88	2	4	7
49	4x50	m1_off	5.71667	5.5925	3	4	9
50	E2.L183	m1_off	7.14	6.56	1	4	7
51	5x41	m1_off	4.925	5.9725	2	4	7
52	5x68	m1_off	4.86	5.7	1	5	8
53	6x47	m1_off	4.70667	4.215	3	4	8
54	E3.V395	m1_off	3.285	5.975	2	4	6
55	8x54	m1_off	4.93333	6.6925	3	4	9

Orange: nodes, hubs and links specific of m1_on network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of m1_off network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	m1_on Recurrence	m1_off Recurrence	m1_on Hub1?	m1_off Hub1?	m1_on Hub2?	m1_off Hub2?	ConSurf1	ConSurf2
1	1x39	7x39	m1_on	12.5221	1.74361	Yes	Yes	Yes	No	6	8
2	7x39	7x42	m1_on	12.4434	0	Yes	No	Yes	Yes	8	8
3	3x36	Lig	m1_on	17.3047	0.734785	No	No	Yes	Yes	8	0
4	2x53	3x36	m1_on	19.3269	0	No	Yes	No	No	8	8
5	3x37	4x53	m1_on	100	9.19987	Yes	Yes	No	No	8	8
6	3x38	4x53	m1_on	93.4462	5.79396	No	No	No	No	8	8
7	3x38	4x50	m1_on	92.3194	4.64661	No	No	No	Yes	8	9
8	3x42	4x50	m1_on	90.0364	1.16542	No	No	No	Yes	8	9
9	2x45	3x42	m1_on	88.8801	0	No	No	No	No	9	8
10	2x45	4x46	m1_on	87.714	0	No	No	No	No	9	9
11	2x42	4x46	m1_on	86.5381	6.30289	No	Yes	No	No	8	9
12	3x49	I2x57	m1_on	71.3639	0.261993	No	No	Yes	Yes	9	8
13	2x38	2x41	m1_on	31.6867	0	Yes	No	No	No	7	7
14	1x57	2x44	m1_on	26.9189	9.44379	No	No	No	No	8	7
15	1x54	2x44	m1_on	25.31	6.30289	No	No	No	No	7	7
16	1x54	2x47	m1_on	22.0626	0	No	No	No	No	7	9
17	1x52	8x54	m1_on	12.0842	3.8004	No	No	No	Yes	8	9
18	2x37	2x38	m1_on	31.48	0	No	No	Yes	No	8	7
19	2x37	2x40	m1_on	29.9006	1.27383	No	No	No	No	8	9
20	2x40	8x50	m1_on	26.7123	2.35794	No	No	Yes	Yes	9	9
21	3x40	Lig	m1_on	45.9211	0	No	No	Yes	Yes	9	0
22	3x40	6x44	m1_on	45.1535	0	No	No	Yes	Yes	9	9
23	3x43	7x53	m1_on	43.4363	0	Yes	No	Yes	No	8	9
24	2x63	2x64	m1_on	10.1112	0	Yes	No	No	No	7	7
25	3x25	E1x50	m1_on	19.8731	1.7406	No	No	Yes	Yes	9	9
26	3x25	3x26	m1_on	17.6983	0	No	No	No	No	9	7
27	3x26	E2.R171	m1_on	10.1309	1.73156	No	No	Yes	Yes	7	7
28	5x54	6x44	m1_on	49.9459	1.67736	No	No	Yes	Yes	9	9
29	3x47	5x54	m1_on	48.7798	1.04496	No	No	No	No	9	9
30	3x47	5x57	m1_on	24.8918	0	No	No	No	No	9	8
31	5x58	7x53	m1_on	25.123	0	Yes	No	Yes	No	9	9
32	3x47	5x58	m1_on	24.2767	0	No	No	Yes	No	9	9
33	5x47	Lig	m1_on	14.756	0	Yes	Yes	Yes	Yes	9	0
34	5x47	5x48	m1_on	11.9957	0	Yes	Yes	Yes	No	9	7
35	5x58	6x37	m1_on	35.7361	0	Yes	No	No	No	9	9
36	6x40	7x53	m1_on	13.6636	0	Yes	No	Yes	No	8	9
37	5x62	6x37	m1_on	26.8599	0	Yes	No	No	No	7	9
38	5x62	5x66	m1_on	13.4718	0	Yes	No	No	No	7	7
39	7x34	7x38	m1_on	10.2588	0	Yes	Yes	Yes	Yes	7	7
40	3x37	4x57	m1_on	17.964	9.47089	Yes	Yes	Yes	Yes	8	8
41	7x42	Lig	Shared	43.2887	81.6063	Yes	Yes	Yes	Yes	8	0
42	2x53	7x46	Shared	12.714	52.0914	No	Yes	No	No	8	9
43	2x50	7x46	Shared	11.8727	51.0856	Yes	Yes	No	No	9	9
44	1x50	2x50	Shared	11.2576	43.8763	Yes	Yes	Yes	Yes	9	9
45	3x37	Lig	Shared	89.2196	48.6765	Yes	Yes	Yes	Yes	8	0
46	2x42	3x49	Shared	82.9512	15.6895	No	Yes	No	No	8	9
47	2x38	I2x57	Shared	69.0907	36.9049	Yes	No	Yes	Yes	7	8
48	1x57	2x41	Shared	30.1073	18.5834	No	No	No	No	8	7
49	1x53	2x47	Shared	20.4241	38.5461	No	No	No	No	9	9
50	1x53	8x54	Shared	17.1177	32.0264	No	No	No	Yes	9	9
51	8x50	I1x50	Shared	20.2175	17.2403	Yes	Yes	No	No	9	9
52	1x60	I1x50	Shared	18.5692	16.1261	Yes	Yes	No	No	8	9
53	2x38	4x39	Shared	10.3867	31.0236	Yes	No	No	No	7	5
54	3x43	6x44	Shared	49.4096	15.9244	Yes	No	Yes	Yes	8	9
55	6x48	Lig	Shared	48.6076	68.0941	Yes	Yes	Yes	Yes	8	0
56	6x44	6x48	Shared	51.8599	15.4245	Yes	Yes	Yes	Yes	9	8
57	2x60	3x28	Shared	40.9467	32.195	Yes	Yes	Yes	Yes	7	7
58	2x60	2x64	Shared	19.3072	32.2733	Yes	Yes	No	No	7	7
59	2x60	7x38	Shared	35.0915	28.9126	Yes	Yes	Yes	Yes	7	7
60	3x28	E1x50	Shared	31.6522	26.9582	Yes	Yes	Yes	Yes	7	9
61	3x33	Lig	Shared	26.6532	15.313	Yes	Yes	Yes	Yes	8	0
62	4x57	4x61	Shared	14.2049	12.5124	Yes	Yes	Yes	Yes	8	7
63	3x33	E2x52	Shared	33.7483	14.256	Yes	Yes	Yes	Yes	8	7
64	3x48	5x57	Shared	11.4594	40.6902	No	No	No	No	7	8
65	3x49	I2x53	Shared	10.3671	18.5503	No	No	Yes	Yes	9	9
66	3x51	5x57	Shared	11.4594	52.0975	No	Yes	No	No	8	8
67	3x30	4x61	Shared	11.1395	20.571	No	No	Yes	Yes	8	7
68	E2.F182	E2x52	Shared	37.6353	15.0059	Yes	Yes	Yes	Yes	6	7
69	4x64	E2.F182	Shared	22.4808	16.62	Yes	No	Yes	Yes	7	6
70	7x38	Lig	Shared	35.8738	25.2055	Yes	Yes	Yes	Yes	7	0
71	2x60	7x42	Shared	27.8636	33.249	Yes	Yes	Yes	Yes	7	8
72	6x51	Lig	m1_off	2.74552	16.6772	Yes	No	Yes	Yes	8	0
73	6x52	Lig	m1_off	0	12.6901	No	No	Yes	Yes	8	0
74	2x64	NT.K20	m1_off	0	28.9999	No	No	No	Yes	7	0
75	1x32	NT.K20	m1_off	0	22.5193	No	No	No	Yes	4	0
76	1x32	2x65	m1_off	0	13.9639	No	No	No	No	4	6
77	2x61	2x65	m1_off	1.59909	10.5068	No	No	No	No	8	6
78	2x57	7x42	m1_off	1.44657	16.4995	No	Yes	Yes	Yes	8	8
79	2x53	7x42	m1_off	0	59.0538	No	Yes	Yes	Yes	8	8
80	1x50	2x47	m1_off	0	39.6242	Yes	Yes	No	No	9	9
81	1x56	8x50	m1_off	1.75162	25.4434	No	No	Yes	Yes	9	9
82	1x56	8x54	m1_off	0	26.5938	No	No	No	Yes	9	9
83	2x41	4x39	m1_off	0	21.7033	No	No	No	No	7	5
84	I2x53	I2x57	m1_off	1.63354	45.5777	Yes	Yes	Yes	Yes	9	8
85	3x52	I2x53	m1_off	1.75162	78.9201	No	Yes	Yes	Yes	7	9
86	3x48	3x52	m1_off	0	39.308	No	No	No	Yes	7	7
87	5x53	5x57	m1_off	0	93.8597	No	No	No	No	7	8
88	3x44	5x53	m1_off	2.30762	95.0914	No	No	No	No	7	7
89	3x44	5x50	m1_off	4.61031	96.3231	No	No	No	No	7	9
90	3x40	5x50	m1_off	0	100	No	No	No	No	9	9
91	3x37	3x40	m1_off	0	53.8411	Yes	Yes	No	No	8	9
92	3x51	3x52	m1_off	0	42.3736	No	Yes	No	Yes	8	7
93	3x40	6x48	m1_off	0.127928	48.8632	No	No	Yes	Yes	9	8
94	2x63	E1x50	m1_off	0.467428	18.8755	Yes	No	Yes	Yes	7	9
95	2x63	E2.Q177	m1_off	5.11218	17.1891	Yes	No	No	No	7	4
96	E2.V173	E2x51	m1_off	2.55363	10.3834	No	No	No	No	4	4
97	E2.L174	E2x51	m1_off	0	12.0938	No	No	No	No	3	4
98	E2.L174	E2.Q177	m1_off	2.55855	13.7983	No	No	No	No	3	4
99	3x33	4x61	m1_off	5.97323	10.6785	Yes	Yes	Yes	Yes	8	7
100	3x30	4x58	m1_off	0	12.7895	No	No	No	No	8	6
101	3x43	6x41	m1_off	0	15.5509	Yes	No	No	No	8	7
102	6x37	6x41	m1_off	0	14.8402	No	No	No	No	9	7
103	3x50	6x37	m1_off	0	14.0964	No	Yes	No	No	9	9
104	3x50	5x61	m1_off	0	10.7116	No	Yes	No	No	9	9
105	5x43	Lig	m1_off	0	10.022	No	No	Yes	Yes	8	0
106	6x51	7x34	m1_off	0	22.3899	Yes	No	Yes	Yes	8	7
107	6x58	7x34	m1_off	1.49085	11.3079	No	No	Yes	Yes	5	7
108	5x37	6x58	m1_off	0	10.0521	No	No	No	No	5	5
109	5x48	6x52	m1_off	2.16493	12.8617	Yes	No	No	No	7	8
110	5x45	5x48	m1_off	6.14544	11.2747	No	No	Yes	No	6	7
111	6x47	6x48	m1_off	2.77996	11.8891	No	Yes	Yes	Yes	8	8

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
3x32	Lig	Shared	4.33	9.68	1	1	1	0
3x33	Lig	Shared	20.96	13.38	1	1	1	0
3x36	Lig	Shared	9.59	11.78	1	1	1	0
3x37	Lig	Shared	5.1	10.44	1	1	1	0
4x57	Lig	Shared	8	7.31	1	1	1	0
5x43	Lig	m1_off	4.71	0	0	0	1	0
5x461	Lig	m1_off	4.02	0	1	0	1	0
6x48	Lig	Shared	10.91	16.25	1	1	1	0
6x51	Lig	Shared	14.22	8.36	1	1	1	0
6x52	Lig	m1_off	10.52	0	0	1	1	0
7x38	Lig	Shared	16.47	10.03	1	1	1	0
7x41	Lig	Shared	6.08	4.53	1	1	1	0
7x42	Lig	Shared	4.49	5.85	1	1	1	0
2x53	2x56	m1_off	7.74	0	1	0	2	2
2x53	7x42	m1_off	4.84	0	1	0	2	1
2x56	3x32	Shared	11.78	10.31	1	1	2	1
2x56	7x42	Shared	3.82	3.82	1	1	2	1
2x57	7x42	Shared	13.17	11.97	0	1	2	1
2x60	7x38	Shared	19.86	11.91	1	1	2	1
2x60	7x42	Shared	7.94	6.95	1	1	2	1
3x32	7x38	m1_off	4.6	0	1	1	1	1
3x32	7x42	Shared	10.34	9.2	1	1	1	1
3x33	4x57	Shared	15.43	16.4	1	1	1	1
3x33	4x61	Shared	3.63	3.63	1	1	1	2
3x33	E2x52	Shared	8.46	7.25	1	1	1	2
3x33	7x38	Shared	4.96	6.95	1	1	1	1
3x36	6x48	Shared	6.18	3.71	1	1	1	1
3x37	3x40	m1_off	4.3	0	1	1	1	1
3x37	4x53	Shared	5.78	5.78	1	1	1	2
3x37	4x57	Shared	8.76	8.76	1	1	1	1
3x37	5x461	Shared	4.55	4.55	1	1	1	1
3x40	5x50	m1_off	3.53	0	0	1	1	2
3x40	6x48	Shared	3.68	4.9	0	1	1	1
4x57	4x61	Shared	3.52	3.52	1	1	1	2
4x61	E2x52	Shared	5.89	5.89	1	1	2	2
E2.L183	E2x52	Shared	7.14	7.14	1	0	2	2
5x43	E2.L183	m1_off	4.42	0	0	0	1	2
5x47	5x51	Shared	7.87	7.87	1	1	1	2
5x47	6x44	m1_off	5.36	0	1	1	1	2
5x47	6x48	Shared	7.02	6.01	1	1	1	1
5x47	6x52	Shared	22.96	25.37	1	1	1	1
5x48	6x52	Shared	5.81	3.49	0	1	2	1
6x44	6x48	Shared	17.04	8.02	1	1	2	1
6x44	7x45	m1_off	3.62	0	1	1	2	2
6x47	6x48	Shared	3.64	3.64	1	1	2	1
6x47	7x45	Shared	5.85	7.31	1	1	2	2
6x48	7x41	Shared	11.75	16.98	1	1	1	1
6x48	7x45	Shared	7.91	10.17	1	1	1	2
6x51	7x34	m1_off	6.75	0	1	1	1	2
6x51	7x38	Shared	7.94	3.97	1	1	1	1
7x38	7x42	m1_off	6.95	0	1	1	1	1
4x56	4x57	m1_off	3.42	0	0	0	2	1
3x41	4x53	m1_off	3.07	0	0	0	2	2
5x44	Lig	m1_off	2.01	0	0	0	1	0
2x53	3x36	m1_on	0	4.64	1	0	2	1
2x57	7x39	m1_on	0	8.14	0	1	2	2
2x60	7x39	m1_on	0	4.82	1	1	2	2
3x33	6x51	m1_on	0	7.94	1	1	1	1
3x37	3x41	m1_on	0	5.44	1	1	1	2
3x40	6x44	m1_on	0	3.93	0	1	1	2
3x40	Lig	m1_on	0	5.31	0	1	1	0
4x57	5x43	m1_on	0	4.85	1	1	1	1
5x47	5x48	m1_on	0	11.35	1	1	1	2
5x47	6x49	m1_on	0	3.89	1	1	1	2
5x47	Lig	m1_on	0	5.21	1	1	1	0
5x51	6x44	m1_on	0	3.93	0	0	2	2
6x51	6x52	m1_on	0	8.14	1	1	1	1
6x51	6x55	m1_on	0	6.31	1	1	1	2
7x39	7x42	m1_on	0	18.33	0	1	2	1
7x34	7x38	m1_on	0	2.89	1	0	2	1
3x37	4x56	m1_on	0	2.66	1	1	1	2
5x44	5x48	m1_on	0	1.33	0	0	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	m1_off	5CXV-M₁-Tiotropium
	m1_on	6OIJ-M₁-Iperoxo-chim(NtGi1L-G11)/β1/γ2

Network Difference
Value	m1_on	m1_off
I_min	3.42	3.5
Number of Linked Nodes	261	261
Number of Specific Nodes	23 (8.81%)	23 (8.81%)
Number of Shared Nodes	238 (91.19%)	238 (91.19%)
Number of Links	288	299
Number of Specific Links	118 (40.97%)	129 (43.14%)
Number of Shared Links	170 (59.03%)	170 (56.86%)
Number of Hubs	39	40
Number of Specific Hubs	15 (38.46%)	16 (40.00%)
Number of Shared Hubs	24 (61.54%)	24 (60.00%)
Average % Shared Neighbours (Jaccard)	39.62
Average % Shared Neighbours (Otsuka)	47.85
Average % Shared Neighbours (Overlap Coefficient)	55.86
Average % Shared Cliques (k3-6)	57.65
Graphlets Similarity	0.715653

Paths Difference
Value	m1_on	m1_off
Number Of Nodes in MetaPath	69	69
Specific Nodes in MetaPath	25 (36.23%)	25 (36.23%)
Shared Nodes in MetaPath	238 (91.19%)	238 (91.19%)
Number Of Links MetaPath	71	71
Specific Links in MetaPath	40 (56.34%)	40 (56.34%)
Shared Links in MetaPath	170 (59.03%)	170 (59.03%)
Number of Shortest Paths	48574	70747
Length Of Smallest Path	3	3
Average Path Length	13.8655	14.5152
Length of Longest Path	32	34
Minimum Path Strength	1.335	1.32
Average Path Strength	6.61939	6.3387
Maximum Path Strength	16.755	18.1467
Minimum Path Correlation	0.7	0.7
Average Path Correlation	0.944998	0.923326
Maximum Path Correlation	0.99	0.99
Minimum % Of Corr. Nodes	3.84615	4.16667
Average % Of Corr. Nodes	62.0855	45.2905
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	46.681	44.888
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download m1_off_on.zip<

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