psnGPCR

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Orange: nodes, hubs and links specific of m2_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of m2_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	m2_off Int. Strength	m2_on Int. Strength	m2_off Hub1?	m2_on Hub1?	m2_off Hub2?	m2_on Hub2?	ConSurf1	ConSurf2
1	1x31	NT.Y18	m2_off	5.61333	0	No	No	No	No	5	5
2	1x28	1x31	m2_off	4.05	0	No	No	No	No	5	5
3	1x44	1x48	m2_off	6.18667	0	No	No	No	No	6	5
4	1x46	2x54	m2_off	3.64	0	No	No	No	No	8	8
5	1x47	2x51	m2_off	4.28	0	No	No	No	No	7	8
6	1x50	2x47	m2_off	4.17	0	No	Yes	No	No	9	9
7	1x51	2x51	m2_off	5.71	0	No	No	No	No	6	8
8	1x53	7x53	m2_off	8.41	0	No	No	No	Yes	9	9
9	1x54	2x51	m2_off	4.24	0	No	No	No	No	7	8
10	1x55	8x57	m2_off	4.47	0	No	No	No	No	6	7
11	1x56	8x53	m2_off	6.4	0	No	No	No	No	9	8
12	1x56	8x57	m2_off	4	0	No	No	No	No	9	7
13	1x57	2x40	m2_off	4.72	0	No	No	No	No	8	9
14	1x57	8x50	m2_off	5.02	0	No	No	Yes	No	8	9
15	1x60	8x53	m2_off	8.77	0	No	No	No	No	8	8
16	I1x48	I1x51	m2_off	10.1233	0	No	No	No	No	8	8
17	8x53	I1x50	m2_off	3.93	0	No	No	Yes	No	8	9
18	2x39	I2x57	m2_off	7.63333	0	No	No	Yes	Yes	9	8
19	2x40	8x50	m2_off	6.04	0	No	No	Yes	No	9	9
20	2x43	7x53	m2_off	15.24	0	No	No	No	Yes	8	9
21	2x45	4x46	m2_off	7.74	0	No	No	No	No	9	9
22	2x46	3x42	m2_off	6.41	0	No	Yes	No	No	9	9
23	2x50	3x39	m2_off	10.3233	0	Yes	Yes	Yes	No	9	9
24	2x52	3x31	m2_off	4.28	0	No	No	No	No	8	6
25	2x53	2x56	m2_off	5.67333	0	Yes	No	Yes	No	8	8
26	2x53	7x42	m2_off	5.64	0	Yes	No	Yes	Yes	8	9
27	2x53	7x46	m2_off	7.74	0	Yes	No	No	No	8	9
28	2x56	3x28	m2_off	3.70667	0	Yes	No	Yes	Yes	8	7
29	2x57	7x42	m2_off	4.79	0	Yes	Yes	Yes	Yes	9	9
30	2x60	2x64	m2_off	7.07667	0	Yes	Yes	No	No	8	7
31	2x62	2x66	m2_off	5.23333	0	No	No	No	No	5	6
32	2x62	E1x51	m2_off	3.83	0	No	No	Yes	No	5	4
33	2x62	E1x52	m2_off	4.15	0	No	No	Yes	No	5	8
34	2x66	E1x49	m2_off	8.05667	0	No	No	No	No	6	4
35	E1x50	E1x52	m2_off	9.11	0	Yes	Yes	Yes	No	9	8
36	E1x51	E1x52	m2_off	4.38	0	Yes	No	Yes	No	4	8
37	3x26	E2.R169	m2_off	10.72	0	No	No	Yes	No	7	8
38	3x28	3x32	m2_off	3.72	0	Yes	Yes	Yes	No	7	9
39	3x33	4x61	m2_off	4.03333	0	Yes	Yes	Yes	No	8	8
40	3x33	E2.F181	m2_off	6.53667	0	Yes	Yes	Yes	No	8	5
41	3x36	6x48	m2_off	4.94333	0	No	No	Yes	Yes	8	9
42	3x39	6x44	m2_off	3.56667	0	Yes	No	Yes	No	9	9
43	3x39	6x48	m2_off	5.33333	0	Yes	No	Yes	Yes	9	9
44	3x39	7x45	m2_off	5.62667	0	Yes	No	Yes	No	9	9
45	3x39	7x46	m2_off	5.71	0	Yes	No	No	No	9	9
46	3x43	6x44	m2_off	7.71667	0	No	No	Yes	No	9	9
47	3x44	5x50	m2_off	4.92667	0	No	No	No	No	7	9
48	3x47	6x41	m2_off	3.5	0	No	No	No	No	9	8
49	3x50	3x54	m2_off	4.79333	0	Yes	No	No	No	9	8
50	3x50	5x61	m2_off	6.26	0	Yes	No	No	No	9	9
51	3x50	6x30	m2_off	10.8567	0	Yes	No	No	No	9	9
52	3x50	6x33	m2_off	8.72	0	Yes	No	No	No	9	8
53	3x50	6x34	m2_off	4.74	0	Yes	No	Yes	No	9	8
54	3x52	3x56	m2_off	4.13333	0	No	No	No	No	6	7
55	4x60	E2.F180	m2_off	3.69667	0	No	No	Yes	No	7	7
56	4x61	E2x52	m2_off	6.87	0	Yes	No	Yes	Yes	8	7
57	4x63	4x66	m2_off	3.57667	0	No	No	No	No	7	6
58	4x65	E2.R169	m2_off	12.07	0	No	No	Yes	No	7	8
59	E2.V171	E2x51	m2_off	14.3	0	No	No	No	No	4	4
60	E2.E172	E2.E175	m2_off	11.84	0	No	No	No	No	1	5
61	E2.F180	E2.F181	m2_off	8.21667	0	Yes	No	Yes	No	7	5
62	5x43	E2.F181	m2_off	7.78	0	No	No	Yes	No	9	5
63	5x36	5x38	m2_off	3.65	0	No	No	No	No	7	4
64	5x41	5x45	m2_off	9.21	0	No	Yes	No	No	7	7
65	5x461	Lig	m2_off	5.28667	0	No	No	Yes	Yes	8	0
66	5x47	5x51	m2_off	7.43	0	Yes	Yes	No	No	9	7
67	5x48	6x52	m2_off	3.49	0	Yes	No	No	No	8	7
68	5x54	6x41	m2_off	5.65333	0	No	No	No	No	9	8
69	5x56	5x60	m2_off	3.69	0	No	No	No	No	5	6
70	5x58	5x62	m2_off	7.20667	0	No	Yes	No	No	9	8
71	5x58	6x38	m2_off	22.6667	0	No	Yes	No	No	9	7
72	5x61	6x34	m2_off	4.05333	0	No	No	Yes	No	9	8
73	6x38	6x42	m2_off	8.3	0	No	No	No	No	7	7
74	6x44	7x45	m2_off	4.02667	0	Yes	No	Yes	No	9	9
75	6x48	7x41	m2_off	16.1067	0	Yes	Yes	No	No	9	8
76	6x51	7x34	m2_off	5.78667	0	Yes	Yes	Yes	No	8	6
77	6x52	Lig	m2_off	10.2367	0	No	No	Yes	Yes	7	0
78	6x54	E3.I417	m2_off	7.77667	0	Yes	No	No	Yes	7	7
79	6x54	7x34	m2_off	6.20667	0	Yes	No	Yes	No	7	6
80	6x57	E3.I417	m2_off	6.87	0	No	No	No	Yes	7	7
81	7x45	7x49	m2_off	7.72	0	Yes	No	No	No	9	9
82	8x47	8x50	m2_off	9.67	0	No	No	Yes	No	9	9
83	4x64	4x67	m2_off	3.91333	0	Yes	Yes	No	No	6	5
84	5x60	5x63	m2_off	4.51333	0	No	No	No	No	6	5
85	8x56	CT.H458	m2_off	5.57333	0	No	No	No	No	6	0
86	3x46	6x37	m2_off	3.43333	0	No	No	No	No	9	9
87	6x57	6x60	m2_off	3.34667	0	No	No	No	No	7	7
88	5x58	6x34	m2_off	3.32667	0	No	Yes	Yes	No	9	8
89	3x44	5x54	m2_off	3.3	0	No	No	No	No	7	9
90	3x41	4x49	m2_off	3.22	0	No	No	No	No	8	8
91	6x39	7x52	m2_off	3.01	0	No	No	No	No	8	9
92	1x33	1x37	m2_off	2.98	0	No	No	No	No	6	4
93	5x42	5x45	m2_off	2.93667	0	No	No	No	No	6	7
94	3x50	6x37	m2_off	2.92333	0	Yes	No	No	No	9	9
95	E1x49	E2.G174	m2_off	2.9	0	No	No	No	No	4	3
96	4x40	4x44	m2_off	2.88	0	No	No	No	No	5	4
97	3x44	5x53	m2_off	2.85	0	No	No	No	No	7	7
98	5x53	5x57	m2_off	2.85	0	No	No	Yes	No	7	8
99	3x54	5x64	m2_off	2.82667	0	No	No	No	No	8	7
100	4x41	I2x53	m2_off	2.79333	0	No	No	Yes	Yes	8	9
101	6x60	6x61	m2_off	2.79	0	No	No	No	No	7	7
102	1x45	7x47	m2_off	2.64333	0	No	No	No	No	5	7
103	5x39	E2.F181	m2_off	2.62	0	No	No	Yes	No	8	5
104	3x23	3x27	m2_off	2.48333	0	No	No	No	No	4	6
105	7x36	7x40	m2_off	2.37667	0	No	No	No	No	5	8
106	1x52	8x58	m2_off	2.30333	0	No	No	No	No	8	8
107	5x44	Lig	m2_off	2.29	0	No	No	Yes	Yes	8	0
108	2x41	4x42	m2_off	2.22	0	No	No	No	No	8	8
109	8x59	CT.H458	m2_off	2.19	0	No	No	No	No	4	0
110	5x49	5x50	m2_off	2.18667	0	No	No	No	No	7	9
111	6x32	6x35	m2_off	2.06333	0	No	No	No	No	9	8
112	6x32	6x36	m2_off	2.00333	0	No	No	No	No	9	9
113	7x43	7x48	m2_off	1.96	0	No	No	No	No	6	6
114	4x59	4x63	m2_off	1.92333	0	No	No	No	No	8	7
115	6x61	E3.P415	m2_off	1.88	0	No	No	No	No	7	4
116	1x48	1x49	m2_off	1.76	0	No	No	No	No	5	9
117	5x48	6x53	m2_off	1.68	0	Yes	No	No	No	8	7
118	6x50	6x54	m2_off	1.68	0	No	No	Yes	No	9	7
119	6x40	7x52	m2_off	1.64	0	No	No	No	No	9	9
120	1x55	1x59	m2_off	1.6	0	No	No	No	No	6	7
121	5x51	5x55	m2_off	1.59	0	No	No	No	No	7	6
122	I2x55	I2x56	m2_off	1.52	0	No	No	No	No	5	6
123	7x31	7x35	m2_off	1.46	0	No	No	No	No	4	6
124	1x30	1x34	m2_off	1.43	0	No	No	No	No	3	3
125	4x52	4x56	m2_off	1.38333	0	No	No	No	No	6	8
126	1x31	1x35	m2_off	1.36667	0	No	No	No	No	5	6
127	5x67	5x68	m2_off	1.31667	0	No	No	No	No	6	8
128	4x42	4x43	m2_off	1.3	0	No	No	No	No	8	4
129	I2x50	I2x51	m2_off	1.09333	0	No	No	No	No	9	7
130	E2.S182	E2.T170	m2_off	1.06667	0	No	No	No	No	6	5
131	5x65	6x34	m2_off	1.06667	0	No	No	Yes	No	8	8
132	5x37	6x58	m2_off	1.04	0	No	No	No	No	4	4
133	1x28	NT.S16	m2_off	1.02	0	No	No	No	No	5	0
134	6x31	6x34	m2_off	1	0	No	No	Yes	No	7	8
135	8x56	8x57	m2_off	0.856667	0	No	No	No	No	6	7
136	4x54	4x55	m2_off	0.84	0	No	No	No	No	5	5
137	NT.P17	NT.S16	m2_off	0.593333	0	No	No	No	No	4	0
138	8x55	8x59	m2_off	0.48	0	No	No	No	No	7	4
139	6x29	6x32	m2_off	0.413333	0	No	No	No	No	7	9
140	1x34	1x38	Shared	8.30667	5.24	No	No	No	No	3	4
141	1x39	2x61	Shared	4.47333	5.03	No	No	No	No	7	7
142	1x42	7x43	Shared	4.75667	2.85	No	No	No	No	6	6
143	1x43	2x57	Shared	4.6	3.07	No	No	Yes	Yes	8	9
144	1x43	2x58	Shared	7.94667	5.96	No	No	No	No	8	9
145	1x46	2x57	Shared	4.01333	4.52	No	No	Yes	Yes	8	9
146	1x46	7x47	Shared	9.94333	4.71	No	No	No	No	8	7
147	1x47	2x55	Shared	3.58333	3.07	No	No	No	No	7	5
148	1x50	2x50	Shared	8.52333	6.73	No	Yes	Yes	Yes	9	9
149	1x50	7x50	Shared	8.14667	3.26	No	Yes	No	No	9	9
150	1x52	8x54	Shared	4.05667	4.87	No	No	No	No	8	9
151	1x54	2x44	Shared	9.12333	6.22	No	No	Yes	Yes	7	7
152	1x56	8x54	Shared	7.93	5.28	No	No	No	No	9	9
153	1x57	2x44	Shared	5.02	7.54	No	No	Yes	Yes	8	7
154	1x58	2x44	Shared	4.96	3.72	No	No	Yes	Yes	5	7
155	1x60	I1x49	Shared	5.95333	6.38	No	No	No	No	8	6
156	1x60	I1x50	Shared	9.61	4.12	No	No	Yes	No	8	9
157	8x49	I1x50	Shared	7.37	5.9	No	No	Yes	No	7	9
158	8x50	I1x50	Shared	11.7733	18.27	Yes	No	Yes	No	9	9
159	2x37	2x40	Shared	7.79667	4.39	No	No	No	No	8	9
160	2x38	I2x57	Shared	10.0233	5.23	No	No	Yes	Yes	7	8
161	2x41	4x39	Shared	7.90667	2.5	No	No	No	No	8	5
162	2x42	3x45	Shared	7.12	3.77	Yes	Yes	No	No	8	8
163	2x42	3x46	Shared	5.02	3.77	Yes	Yes	No	No	8	9
164	2x42	3x49	Shared	7.56333	5.97	Yes	Yes	No	Yes	8	9
165	2x42	4x42	Shared	3.69667	2.77	Yes	Yes	No	No	8	8
166	2x42	4x46	Shared	4.18333	3.77	Yes	Yes	No	No	8	9
167	2x45	3x42	Shared	5.46333	8.94	No	No	No	No	9	9
168	2x45	4x50	Shared	6.18	6.18	No	No	No	Yes	9	9
169	2x46	7x49	Shared	6.41	8.24	No	Yes	No	No	9	9
170	2x50	7x46	Shared	8.83	10.31	Yes	Yes	No	No	9	9
171	2x50	7x49	Shared	11.22	12.12	Yes	Yes	No	No	9	9
172	2x52	3x35	Shared	4.09667	3.07	No	No	No	No	8	7
173	2x53	3x35	Shared	3.58333	6.14	Yes	No	No	No	8	7
174	2x55	2x551	Shared	8.74333	3.93	No	No	No	No	5	5
175	2x551	3x31	Shared	4.06	2.44	No	No	No	No	5	6
176	2x56	3x32	Shared	9.81667	10.31	Yes	No	Yes	No	8	9
177	2x56	7x42	Shared	9.32333	6.36	Yes	No	Yes	Yes	8	9
178	2x57	7x39	Shared	7.36667	11.63	Yes	Yes	Yes	Yes	9	9
179	2x59	3x28	Shared	14.4267	9.11	No	No	Yes	Yes	7	7
180	2x60	3x28	Shared	4.17667	4.82	Yes	Yes	Yes	Yes	8	7
181	2x60	7x35	Shared	7.07333	6.24	Yes	Yes	No	No	8	6
182	2x60	7x38	Shared	18.5333	9.93	Yes	Yes	No	Yes	8	7
183	2x60	7x39	Shared	6.43	5.79	Yes	Yes	Yes	Yes	8	9
184	2x60	7x42	Shared	3.97333	4.96	Yes	Yes	Yes	Yes	8	9
185	2x63	E1x50	Shared	6.11	8.68	No	No	Yes	Yes	7	9
186	2x66	E1x51	Shared	4.51667	3.39	No	No	Yes	No	6	4
187	E1x50	E1x51	Shared	5.4	5.4	Yes	Yes	Yes	No	9	4
188	3x25	E1x50	Shared	6.53	7.84	No	No	Yes	Yes	9	9
189	3x28	E1x50	Shared	6.56	8.43	Yes	Yes	Yes	Yes	7	9
190	E1x50	E2x50	Shared	9.58	9.14	Yes	Yes	No	No	9	9
191	3x24	E1x52	Shared	6.45667	10.43	No	No	Yes	No	6	8
192	3x21	3x22	Shared	4.06	4.06	No	No	No	No	7	4
193	3x22	E2.R169	Shared	5.76	11.53	No	No	Yes	No	4	8
194	3x25	E2x50	Shared	7.28	7.28	No	No	No	No	9	9
195	3x26	4x65	Shared	6.09333	3.92	No	No	No	No	7	7
196	3x29	E2x50	Shared	4.23	4.76	No	No	No	No	7	9
197	3x29	E2x52	Shared	4.75667	5.71	No	No	Yes	Yes	7	7
198	3x30	4x61	Shared	4.33	3.25	No	No	Yes	No	8	8
199	3x32	7x42	Shared	8.81333	8.05	Yes	No	Yes	Yes	9	9
200	3x32	Lig	Shared	8.93	5.93	Yes	No	Yes	Yes	9	0
201	3x33	4x57	Shared	15.43	13.5	Yes	Yes	Yes	Yes	8	8
202	3x33	E2x52	Shared	8.86333	12.09	Yes	Yes	Yes	Yes	8	7
203	3x33	Lig	Shared	19.11	13.32	Yes	Yes	Yes	Yes	8	0
204	3x36	Lig	Shared	10.75	7.87	No	No	Yes	Yes	8	0
205	3x37	3x41	Shared	4.21	8.41	No	Yes	No	No	9	8
206	3x37	4x53	Shared	8.94	4.47	No	Yes	No	No	9	9
207	3x37	4x57	Shared	9.04	10.17	No	Yes	Yes	Yes	9	8
208	3x38	4x50	Shared	9.07667	7.78	No	No	No	Yes	8	9
209	3x40	5x50	Shared	3.53	3.53	No	No	No	No	9	9
210	3x47	5x54	Shared	5.11	3.07	No	No	No	No	9	9
211	3x48	5x57	Shared	11.3667	4.87	No	No	Yes	No	7	8
212	3x49	I2x53	Shared	9.58	4.6	No	Yes	Yes	Yes	9	9
213	3x49	I2x57	Shared	15.0867	14.29	No	Yes	Yes	Yes	9	8
214	3x51	3x52	Shared	5.50333	6.19	Yes	Yes	No	No	9	6
215	3x51	3x55	Shared	15.8133	16.23	Yes	Yes	No	No	9	8
216	3x51	5x57	Shared	6.64333	7.03	Yes	Yes	Yes	No	9	8
217	3x51	5x60	Shared	4.72	6.53	Yes	Yes	No	No	9	6
218	3x52	I2x53	Shared	9.97	14.44	No	No	Yes	Yes	6	9
219	3x53	I2x57	Shared	6.03333	4.18	No	No	Yes	Yes	8	8
220	I2x53	I2x57	Shared	6.85667	13.38	Yes	Yes	Yes	Yes	9	8
221	4x54	4x58	Shared	8.32	8.32	No	No	No	No	5	6
222	4x57	4x61	Shared	3.52333	3.52	Yes	Yes	Yes	No	8	8
223	4x57	5x43	Shared	3.64	8.49	Yes	Yes	No	No	8	9
224	4x57	Lig	Shared	3.61333	5.97	Yes	Yes	Yes	Yes	8	0
225	4x62	4x63	Shared	8.12333	4.87	No	No	No	No	6	7
226	4x64	4x68	Shared	8.58	2.45	Yes	Yes	No	No	6	4
227	4x64	E2.Q179	Shared	5.11333	6.57	Yes	Yes	No	No	6	7
228	4x64	E2.F180	Shared	13.0267	8.02	Yes	Yes	Yes	No	6	7
229	4x65	4x66	Shared	10.9333	10.54	No	No	No	No	7	6
230	E2.R169	E2.V171	Shared	10.0233	7.85	Yes	No	No	No	8	4
231	E2.Q179	E2.T170	Shared	12.2867	8.5	No	No	No	No	7	5
232	E2.E175	E2x51	Shared	8.98	2.24	No	No	No	No	5	4
233	E2.F180	E2x52	Shared	7.95667	6.28	Yes	No	Yes	Yes	7	7
234	E2.F181	E2x52	Shared	15.4867	3.77	Yes	No	Yes	Yes	5	7
235	5x40	E2.F181	Shared	12.1067	3.89	No	No	Yes	No	8	5
236	5x36	5x39	Shared	5.42	5.91	No	No	No	No	7	8
237	5x41	6x56	Shared	8.11667	8.53	No	Yes	No	No	7	7
238	5x47	5x48	Shared	7.90667	8.25	Yes	Yes	Yes	No	9	8
239	5x47	6x44	Shared	4.29	5.36	Yes	Yes	Yes	No	9	9
240	5x47	6x48	Shared	4.67667	4.01	Yes	Yes	Yes	Yes	9	9
241	5x47	6x52	Shared	24.9733	14.5	Yes	Yes	No	No	9	7
242	5x51	6x45	Shared	6.14	3.07	No	No	No	No	7	7
243	5x59	5x63	Shared	15.3267	4	No	No	No	No	4	5
244	6x28	6x31	Shared	3.57	1.53	No	No	No	No	5	7
245	6x40	7x53	Shared	4.83667	7.25	No	No	No	Yes	9	9
246	6x44	6x48	Shared	17.7067	10.02	Yes	No	Yes	Yes	9	9
247	6x47	6x48	Shared	4.85	6.06	No	No	Yes	Yes	9	9
248	6x47	7x45	Shared	9.75	11.7	No	No	Yes	No	9	9
249	6x48	7x45	Shared	8.66333	13.56	Yes	Yes	Yes	No	9	9
250	6x48	Lig	Shared	10.43	8.96	Yes	Yes	Yes	Yes	9	0
251	6x50	7x40	Shared	3.83	3.28	No	No	No	No	9	8
252	6x51	6x55	Shared	5.05	5.05	Yes	Yes	No	No	8	8
253	6x51	7x38	Shared	7.94333	5.96	Yes	Yes	No	Yes	8	7
254	6x51	Lig	Shared	16.9067	10.24	Yes	Yes	Yes	Yes	8	0
255	6x54	7x37	Shared	3.49	1.75	Yes	No	No	No	7	6
256	6x58	7x34	Shared	6.02667	7.91	No	No	Yes	No	4	6
257	6x59	6x60	Shared	5.62333	3.89	No	No	No	No	7	7
258	6x61	E3.C416	Shared	7.28	3.64	No	No	No	No	7	7
259	7x34	E3.I417	Shared	12.1333	3.52	Yes	No	No	Yes	6	7
260	7x30	7x33	Shared	6.48	5.3	No	No	No	No	7	5
261	7x38	Lig	Shared	12.58	7.17	No	Yes	Yes	Yes	7	0
262	7x39	7x42	Shared	4.18	8.68	Yes	Yes	Yes	Yes	9	9
263	7x41	Lig	Shared	4.95667	5.55	No	No	Yes	Yes	8	0
264	7x42	Lig	Shared	5.38	5.12	Yes	Yes	Yes	Yes	9	0
265	7x54	8x50	Shared	5.08667	4.16	No	No	Yes	No	8	9
266	8x47	8x49	Shared	4.87667	8.77	No	No	No	No	9	7
267	1x53	2x47	Shared	3.39	3.39	No	No	No	No	9	9
268	E2.Q179	E2.V171	Shared	3.34667	2.87	No	No	No	No	7	4
269	2x61	7x39	Shared	3.23667	4.85	No	No	Yes	Yes	7	9
270	7x51	7x55	Shared	3.15	1.58	No	No	No	No	7	7
271	5x48	6x56	Shared	3.12667	3.52	Yes	No	No	No	8	7
272	4x51	4x55	Shared	3.07	3.07	No	No	No	No	5	5
273	6x54	7x33	Shared	3.04	3.04	Yes	No	No	No	7	5
274	3x47	5x57	Shared	3	6.01	No	No	Yes	No	9	8
275	1x48	1x52	Shared	2.85	2.85	No	No	No	No	5	8
276	E2.D173	E2.G174	Shared	2.79333	1.68	No	No	No	No	3	3
277	I2x53	I2x54	Shared	2.78	4.17	Yes	Yes	No	No	9	7
278	2x49	4x50	Shared	2.59	2.59	No	No	No	Yes	9	9
279	3x56	I2x52	Shared	2.50333	9.01	No	No	No	No	7	6
280	3x45	4x45	Shared	2.43333	2.92	No	No	No	No	8	8
281	1x42	7x39	Shared	2.28	3.42	No	No	Yes	Yes	6	9
282	3x34	4x54	Shared	2.18333	2.62	No	No	No	No	8	5
283	1x36	2x65	Shared	2.13667	3.21	No	No	Yes	Yes	5	6
284	4x68	E2.V168	Shared	2.13667	1.6	No	No	No	No	4	3
285	6x58	E3.A414	Shared	2.08333	1.56	No	No	No	No	4	3
286	6x36	6x40	Shared	2.02667	3.04	No	No	No	No	9	9
287	4x38	4x41	Shared	2.01	1.51	No	No	No	No	9	8
288	3x41	4x52	Shared	1.88333	2.83	No	No	No	No	8	6
289	4x58	4x59	Shared	1.87	1.87	No	No	No	No	6	8
290	6x49	6x50	Shared	1.87	1.87	No	No	No	No	7	9
291	6x43	7x52	Shared	1.81	1.81	No	No	No	No	8	9
292	3x56	I2x50	Shared	1.67	1.67	No	No	No	No	7	9
293	7x55	8x54	Shared	1.62667	3.65	No	No	No	No	7	9
294	1x32	2x65	Shared	1.6	3.21	No	No	Yes	Yes	4	6
295	5x52	5x56	Shared	1.54	1.54	No	No	No	No	5	5
296	7x32	7x36	Shared	1.52	1.52	No	No	No	No	4	5
297	4x38	4x40	Shared	1.5	12.01	No	No	No	No	9	5
298	8x52	8x55	Shared	1.43667	20.11	No	No	No	No	6	7
299	6x42	6x46	Shared	1.43	2.85	No	No	No	No	7	5
300	2x44	2x48	Shared	1.39667	2.79	Yes	Yes	No	No	7	7
301	3x27	4x62	Shared	1.38	1.38	No	No	No	No	6	6
302	1x39	1x40	Shared	1.3	1.95	No	No	No	No	7	4
303	2x61	2x65	Shared	1.06	1.59	No	No	Yes	Yes	7	6
304	2x64	2x65	Shared	1.06	1.59	No	No	Yes	Yes	7	6
305	1x35	2x65	Shared	1.02667	3.07	No	No	Yes	Yes	6	6
306	I2x52	I2x56	Shared	1	6.01	No	No	No	No	6	6
307	1x38	1x42	Shared	0.993333	2.98	No	No	No	No	4	6
308	6x25	6x26	Shared	0.65	1.95	No	No	No	No	5	5
309	6x26	6x27	Shared	0.65	1.95	No	No	No	No	5	4
310	6x36	7x56	Shared	0.563333	1.69	No	No	No	No	9	9
311	2x67	E1x49	Shared	0.483333	1.45	No	No	No	No	6	4
312	7x55	8x51	Shared	0.47	1.41	No	No	No	No	7	9
313	1x29	1x30	m2_on	0	11.67	No	No	No	No	5	3
314	1x46	1x50	m2_on	0	4.39	No	No	No	Yes	8	9
315	1x49	1x52	m2_on	0	3.42	No	No	No	No	9	8
316	1x49	7x50	m2_on	0	4.06	No	No	No	No	9	9
317	1x50	2x51	m2_on	0	6.87	No	Yes	No	No	9	8
318	2x38	4x39	m2_on	0	4.76	No	No	No	No	7	5
319	2x39	3x49	m2_on	0	6.73	No	No	No	Yes	9	9
320	2x46	2x50	m2_on	0	6.79	No	Yes	Yes	Yes	9	9
321	2x46	3x43	m2_on	0	4.15	No	Yes	No	No	9	9
322	2x53	2x54	m2_on	0	3.53	Yes	No	No	No	8	8
323	2x53	3x36	m2_on	0	4.64	Yes	No	No	No	8	8
324	2x54	2x57	m2_on	0	5.24	No	No	Yes	Yes	8	9
325	2x63	E2.E175	m2_on	0	10.1	No	No	No	No	7	5
326	2x64	7x35	m2_on	0	4.71	No	No	No	No	7	6
327	3x24	E1x50	m2_on	0	6.13	No	No	Yes	Yes	6	9
328	3x28	3x29	m2_on	0	5.69	Yes	Yes	No	No	7	7
329	3x33	6x51	m2_on	0	4.96	Yes	Yes	Yes	Yes	8	8
330	3x33	7x38	m2_on	0	5.96	Yes	Yes	No	Yes	8	7
331	3x37	4x56	m2_on	0	4.12	No	Yes	No	No	9	8
332	3x38	4x53	m2_on	0	3.42	No	No	No	No	8	9
333	3x40	6x48	m2_on	0	6.13	No	No	Yes	Yes	9	9
334	3x42	4x50	m2_on	0	3.39	No	No	No	Yes	9	9
335	3x43	7x53	m2_on	0	5.86	No	No	No	Yes	9	9
336	3x44	3x48	m2_on	0	4.87	No	No	No	No	7	7
337	3x46	3x50	m2_on	0	6.26	No	No	Yes	No	9	9
338	3x46	7x53	m2_on	0	6.04	No	No	No	Yes	9	9
339	3x47	5x58	m2_on	0	5.09	No	No	No	Yes	9	9
340	3x48	5x53	m2_on	0	3.77	No	No	No	No	7	7
341	3x50	5x58	m2_on	0	7.2	Yes	No	No	Yes	9	9
342	3x50	7x53	m2_on	0	5.14	Yes	No	No	Yes	9	9
343	3x51	5x61	m2_on	0	3.63	Yes	Yes	No	No	9	9
344	3x53	I2x53	m2_on	0	4.03	No	No	Yes	Yes	8	9
345	4x43	4x46	m2_on	0	3.53	No	No	No	No	4	9
346	4x56	4x57	m2_on	0	9.11	No	No	Yes	Yes	8	8
347	4x64	5x36	m2_on	0	6.78	Yes	Yes	No	No	6	7
348	5x39	E2.F180	m2_on	0	5.24	No	No	Yes	No	8	7
349	5x41	6x59	m2_on	0	6.49	No	Yes	No	No	7	7
350	5x41	6x60	m2_on	0	5.36	No	Yes	No	No	7	7
351	5x45	5x48	m2_on	0	6.04	No	No	Yes	No	7	8
352	5x49	5x53	m2_on	0	4.28	No	No	No	No	7	7
353	5x51	6x44	m2_on	0	3.93	No	No	Yes	No	7	9
354	5x58	6x37	m2_on	0	12.09	No	Yes	No	No	9	9
355	5x58	6x41	m2_on	0	4.69	No	Yes	No	No	9	8
356	5x62	6x34	m2_on	0	4.8	No	No	Yes	No	8	8
357	5x65	6x33	m2_on	0	6.46	No	No	No	No	8	8
358	6x51	6x52	m2_on	0	4.65	Yes	Yes	No	No	8	7
359	6x51	7x41	m2_on	0	4.03	Yes	Yes	No	No	8	8
360	6x57	E3.C416	m2_on	0	6.55	No	No	No	No	7	7
361	6x58	E3.I417	m2_on	0	4.25	No	No	No	Yes	4	7
362	E3.C416	E3.I417	m2_on	0	4.91	No	No	No	Yes	7	7
363	7x30	E3.I417	m2_on	0	3.39	No	No	No	Yes	7	7
364	7x34	7x38	m2_on	0	7.72	Yes	No	No	Yes	6	7
365	7x38	7x42	m2_on	0	4.96	No	Yes	Yes	Yes	7	9
366	7x47	7x48	m2_on	0	4.56	No	No	No	No	7	6
367	7x48	7x52	m2_on	0	4.91	No	No	No	No	6	9
368	E2.E172	E2x51	m2_on	0	3.37	No	No	No	No	1	4
369	3x30	4x62	m2_on	0	3.15	No	No	No	No	8	6
370	3x25	3x26	m2_on	0	3.11	No	No	No	No	9	7
371	1x43	1x47	m2_on	0	3.1	No	No	No	No	8	7
372	5x67	5x69	m2_on	0	3.1	No	No	No	No	6	5
373	1x53	1x57	m2_on	0	3.07	No	No	No	No	9	8
374	3x54	5x61	m2_on	0	3.07	No	No	No	No	8	9
375	2x46	3x39	m2_on	0	3	No	Yes	Yes	No	9	9
376	5x55	6x41	m2_on	0	2.95	No	No	No	No	6	8
377	6x34	6x38	m2_on	0	2.95	Yes	No	No	No	8	7
378	1x48	1x51	m2_on	0	2.94	No	No	No	No	5	6
379	8x53	8x56	m2_on	0	2.74	No	No	No	No	8	6
380	1x56	8x50	m2_on	0	2.64	No	No	Yes	No	9	9
381	4x63	4x67	m2_on	0	2.51	No	No	No	No	7	5
382	3x56	I2x53	m2_on	0	2.39	No	No	Yes	Yes	7	9
383	E3.A414	E3.P415	m2_on	0	1.87	No	No	No	No	3	4
384	1x53	7x50	m2_on	0	1.77	No	No	No	No	9	9
385	2x66	2x67	m2_on	0	1.76	No	No	No	No	6	6
386	7x36	7x37	m2_on	0	1.76	No	No	No	No	5	6
387	5x37	6x59	m2_on	0	1.68	No	No	No	No	4	7
388	6x27	6x31	m2_on	0	1.67	No	No	No	No	4	7
389	E2.E175	E2.G174	m2_on	0	1.64	No	No	No	No	5	3
390	1x55	1x56	m2_on	0	1.62	No	No	No	No	6	9
391	3x34	4x53	m2_on	0	1.62	No	No	No	No	8	9
392	3x45	4x49	m2_on	0	1.62	No	No	No	No	8	8
393	6x45	6x49	m2_on	0	1.62	No	No	No	No	7	7
394	2x37	2x38	m2_on	0	1.59	No	No	No	No	8	7
395	5x55	5x56	m2_on	0	1.59	No	No	No	No	6	5
396	2x43	7x54	m2_on	0	1.58	No	No	No	No	8	8
397	8x49	8x53	m2_on	0	1.57	No	No	No	No	7	8
398	5x44	6x52	m2_on	0	1.56	No	No	No	No	8	7
399	8x47	8x48	m2_on	0	1.56	No	No	No	No	9	5
400	5x51	5x52	m2_on	0	1.54	No	No	No	No	7	5
401	6x33	6x37	m2_on	0	1.54	No	No	No	No	8	9
402	6x53	6x54	m2_on	0	1.52	No	No	Yes	No	7	7
403	5x41	5x42	m2_on	0	1.51	No	Yes	No	No	7	6
404	1x59	1x60	m2_on	0	1.48	No	No	No	No	7	8
405	I2x51	I2x52	m2_on	0	1.47	No	No	No	No	7	6
406	5x69	5x70	m2_on	0	1.45	No	No	No	No	5	0
407	4x41	4x44	m2_on	0	1.44	No	No	No	No	8	4
408	6x30	6x34	m2_on	0	1.41	No	No	Yes	No	9	8
409	5x66	6x30	m2_on	0	1.35	No	No	No	No	7	9
410	5x67	6x29	m2_on	0	1.32	No	No	No	No	6	7
411	4x57	5x461	m2_on	0	1.3	Yes	Yes	No	No	8	8
412	5x68	5x69	m2_on	0	1.25	No	No	No	No	8	5
413	4x41	I2x57	m2_on	0	1.24	No	No	Yes	Yes	8	8
414	6x31	6x35	m2_on	0	1.24	No	No	No	No	7	8
415	1x30	1x31	m2_on	0	1.17	No	No	No	No	3	5
416	5x59	5x60	m2_on	0	1.06	No	No	No	No	4	6

Orange: nodes, hubs and links specific of m2_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of m2_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	m2_off Avg Int. Strength	m2_on Avg Int. Strength	m2_off Num Of Links	m2_on Num Of Links	ConSurf
1	I1x50	m2_off	8.17083	9.43	4	3	9
2	2x53	m2_off	5.65917	4.77	4	3	8
3	2x56	m2_off	7.13	8.335	4	2	8
4	E1x51	m2_off	4.53167	4.395	4	2	4
5	E1x52	m2_off	6.02417	10.43	4	1	8
6	3x32	m2_off	7.82	8.09667	4	3	9
7	3x39	m2_off	6.112	3	5	1	9
8	3x50	m2_off	6.38222	6.2	6	3	9
9	4x61	m2_off	4.68917	3.385	4	2	8
10	E2.R169	m2_off	9.64333	9.69	4	2	8
11	E2.F180	m2_off	8.22417	6.51333	4	3	7
12	E2.F181	m2_off	8.79111	3.83	6	2	5
13	5x48	m2_off	4.05083	5.93667	4	3	8
14	5x57	m2_off	5.965	5.97	4	3	8
15	6x34	m2_off	2.83733	3.05333	5	3	8
16	6x44	m2_off	7.46133	6.43667	5	3	9
17	6x54	m2_off	4.43867	2.10333	5	3	7
18	7x34	m2_off	7.53833	6.38333	4	3	6
19	7x45	m2_off	7.15733	12.63	5	2	9
20	8x50	m2_off	7.518	8.35667	5	3	9
21	2x42	Shared	5.51667	4.01	5	5	8
22	2x44	Shared	5.125	5.0675	4	4	7
23	2x50	Shared	9.72417	8.9875	4	4	9
24	2x57	Shared	5.1925	6.115	4	4	9
25	2x60	Shared	7.87722	6.348	6	5	8
26	2x65	Shared	1.37667	2.534	5	5	6
27	E1x50	Shared	7.215	7.60333	6	6	9
28	3x28	Shared	6.518	7.0125	5	4	7
29	3x33	Shared	10.7947	9.966	5	5	8
30	3x51	Shared	8.17	7.922	4	5	9
31	I2x53	Shared	6.396	7.16833	5	6	9
32	I2x57	Shared	9.12667	7.664	5	5	8
33	4x57	Shared	7.04933	7.43714	5	7	8
34	4x64	Shared	7.65833	5.955	4	4	6
35	E2x52	Shared	8.78667	6.9625	5	4	7
36	5x47	Shared	9.85533	8.03	5	4	9
37	6x48	Shared	9.08875	8.12333	8	6	9
38	6x51	Shared	8.92167	5.815	4	6	8
39	7x39	Shared	4.69867	6.874	5	5	9
40	7x42	Shared	6.01429	6.355	7	6	9
41	Lig	Shared	9.20583	7.79222	12	9	0
42	1x50	m2_on	6.94667	5.3125	3	4	9
43	2x46	m2_on	6.41	5.545	2	4	9
44	3x37	m2_on	7.39667	6.7925	3	4	9
45	3x49	m2_on	10.7433	7.8975	3	4	9
46	4x50	m2_on	5.94889	4.985	3	4	9
47	5x41	m2_on	8.66333	5.4725	2	4	7
48	5x58	m2_on	11.0667	7.2675	3	4	9
49	E3.I417	m2_on	8.92667	4.0175	3	4	7
50	7x38	m2_on	13.0189	6.95	3	6	7
51	7x53	m2_on	9.49556	6.0725	3	4	9

Orange: nodes, hubs and links specific of m2_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of m2_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	m2_off Recurrence	m2_on Recurrence	m2_off Hub1?	m2_on Hub1?	m2_off Hub2?	m2_on Hub2?	ConSurf1	ConSurf2
1	1x31	1x35	m2_off	19.12	0	No	No	No	No	5	6
2	1x35	2x65	m2_off	22.6753	2.14851	No	No	Yes	Yes	6	6
3	2x61	2x65	m2_off	12.8827	7.73585	No	No	Yes	Yes	7	6
4	1x42	7x39	m2_off	10.9982	7.41935	No	No	Yes	Yes	6	9
5	2x53	7x42	m2_off	49.5562	0	Yes	No	Yes	Yes	8	9
6	2x53	3x35	m2_off	56.2301	3.6336	Yes	No	No	No	8	7
7	2x52	3x35	m2_off	55.0767	1.81984	No	No	No	No	8	7
8	2x52	3x31	m2_off	53.9137	0	No	No	No	No	8	6
9	2x551	3x31	m2_off	52.7413	1.86853	No	No	No	No	5	6
10	2x55	2x551	m2_off	51.5593	3.73098	No	No	No	No	5	5
11	1x47	2x55	m2_off	50.3679	5.58125	No	No	No	No	7	5
12	1x47	2x51	m2_off	49.1669	0	No	No	No	No	7	8
13	1x54	2x51	m2_off	46.7271	0	No	No	No	No	7	8
14	1x54	2x44	m2_off	45.5974	1.86853	No	No	Yes	Yes	7	7
15	1x57	2x44	m2_off	41.8522	7.41935	No	No	Yes	Yes	8	7
16	1x57	8x50	m2_off	37.7652	0	No	No	Yes	No	8	9
17	8x53	I1x50	m2_off	27.3556	0	No	No	Yes	No	8	9
18	1x56	8x53	m2_off	26.1641	0	No	No	No	No	9	8
19	2x64	2x65	m2_off	20.862	2.44674	No	No	Yes	Yes	7	6
20	2x60	2x64	m2_off	23.3541	0	Yes	Yes	No	No	8	7
21	2x60	7x42	m2_off	18.6026	9.25746	Yes	Yes	Yes	Yes	8	9
22	2x53	7x46	m2_off	43.1575	0	Yes	No	No	No	8	9
23	2x50	7x46	m2_off	39.213	1.86853	Yes	Yes	No	No	9	9
24	1x50	2x47	m2_off	18.9253	0	No	Yes	No	No	9	9
25	1x53	2x47	m2_off	17.5013	1.86853	No	No	No	No	9	9
26	1x53	7x53	m2_off	16.0583	0	No	No	No	Yes	9	9
27	1x56	8x57	m2_off	11.9239	0	No	No	No	No	9	7
28	2x50	7x49	m2_off	37.0912	1.50335	Yes	Yes	No	No	9	9
29	2x46	7x49	m2_off	100	0.389531	No	Yes	No	No	9	9
30	2x46	3x42	m2_off	98.7658	0	No	Yes	No	No	9	9
31	2x45	3x42	m2_off	97.5222	0	No	No	No	No	9	9
32	2x45	4x46	m2_off	92.4527	0	No	No	No	No	9	9
33	2x42	4x46	m2_off	91.1615	4.3031	Yes	Yes	No	No	8	9
34	6x48	7x45	m2_off	60.1699	1.6129	Yes	Yes	Yes	No	9	9
35	7x45	7x49	m2_off	64.4325	0	Yes	No	No	No	9	9
36	3x39	6x48	m2_off	11.7625	0	Yes	No	Yes	Yes	9	9
37	2x56	3x28	m2_off	10.571	0	Yes	No	Yes	Yes	8	7
38	3x28	3x32	m2_off	10.5805	0	Yes	Yes	Yes	No	7	9
39	3x33	E2.F181	m2_off	38.7763	0	Yes	Yes	Yes	No	8	5
40	E2.F180	E2.F181	m2_off	34.8982	0	Yes	No	Yes	No	7	5
41	4x65	E2.R169	m2_off	30.5407	0	No	No	Yes	No	7	8
42	3x52	I2x53	m2_off	41.781	6.7255	No	No	Yes	Yes	6	9
43	3x51	3x52	m2_off	30.1514	6.64638	Yes	Yes	No	No	9	6
44	3x46	6x37	m2_off	27.0993	0	No	No	No	No	9	9
45	3x50	6x37	m2_off	25.6467	0	Yes	No	No	No	9	9
46	3x50	6x34	m2_off	15.9681	0	Yes	No	Yes	No	9	8
47	3x52	3x56	m2_off	10.9603	0	No	No	No	No	6	7
48	4x65	4x66	m2_off	28.0676	2.2885	No	No	No	No	7	6
49	4x63	4x66	m2_off	25.5328	0	No	No	No	No	7	6
50	4x59	4x63	m2_off	15.6311	0	No	No	No	No	8	7
51	4x58	4x59	m2_off	13.0488	2.14851	No	No	No	No	6	8
52	4x54	4x58	m2_off	10.4571	4.29093	No	No	No	No	5	6
53	6x52	Lig	m2_off	11.9713	0	No	No	Yes	Yes	7	0
54	5x47	5x51	m2_off	10.1343	0	Yes	Yes	No	No	9	7
55	6x40	7x53	m2_off	13.3147	5.50822	No	No	No	Yes	9	9
56	6x51	7x34	m2_off	29.4442	0	Yes	Yes	Yes	No	8	6
57	6x54	7x34	m2_off	13.4855	0	Yes	No	Yes	No	7	6
58	1x28	1x31	m2_off	11.1834	0	No	No	No	No	5	5
59	6x51	Lig	m2_off	28.0628	3.58491	Yes	Yes	Yes	Yes	8	0
60	2x57	7x42	m2_off	12.5552	0	Yes	Yes	Yes	Yes	9	9
61	2x53	2x56	m2_off	10.7324	0	Yes	No	Yes	No	8	8
62	2x50	3x39	m2_off	10.5758	0	Yes	Yes	Yes	No	9	9
63	3x32	Lig	m2_off	11.4397	1.20511	Yes	No	Yes	Yes	9	0
64	2x61	7x39	Shared	18.014	13.0493	No	No	Yes	Yes	7	9
65	7x39	7x42	Shared	27.4268	57.1272	Yes	Yes	Yes	Yes	9	9
66	8x50	I1x50	Shared	32.8144	16.4273	Yes	No	Yes	No	9	9
67	1x56	8x54	Shared	13.5378	25.1309	No	No	No	No	9	9
68	1x50	2x50	Shared	21.7449	64.0414	No	Yes	Yes	Yes	9	9
69	2x42	3x49	Shared	58.5513	41.4729	Yes	Yes	No	Yes	8	9
70	7x42	Lig	Shared	59.363	44.1935	Yes	Yes	Yes	Yes	9	0
71	6x48	Lig	Shared	72.953	48.8618	Yes	Yes	Yes	Yes	9	0
72	2x60	7x38	Shared	14.4586	37.9124	Yes	Yes	No	Yes	8	7
73	7x38	Lig	Shared	11.1027	16.1229	No	Yes	Yes	Yes	7	0
74	2x42	3x46	Shared	28.8033	53.4571	Yes	Yes	No	No	8	9
75	3x28	E1x50	Shared	22.5139	35.9099	Yes	Yes	Yes	Yes	7	9
76	E1x50	E1x51	Shared	12.522	10.2921	Yes	Yes	Yes	No	9	4
77	3x33	Lig	Shared	75.07	21.0651	Yes	Yes	Yes	Yes	8	0
78	3x33	E2x52	Shared	35.6624	50	Yes	Yes	Yes	Yes	8	7
79	E2.F180	E2x52	Shared	36.8254	45.8065	Yes	No	Yes	Yes	7	7
80	4x64	E2.F180	Shared	66.991	35.35	Yes	Yes	Yes	No	6	7
81	4x64	E2.Q179	Shared	57.4026	21.3938	Yes	Yes	No	No	6	7
82	E2.Q179	E2.V171	Shared	50.1115	14.3092	No	No	No	No	7	4
83	E2.R169	E2.V171	Shared	40.2573	10.7486	Yes	No	No	No	8	4
84	4x57	Lig	Shared	11.2925	33.6336	Yes	Yes	Yes	Yes	8	0
85	3x37	4x57	Shared	11.0172	26.975	No	Yes	Yes	Yes	9	8
86	3x49	I2x53	Shared	50.5293	16.8168	No	Yes	Yes	Yes	9	9
87	3x51	5x57	Shared	18.0567	16.1473	Yes	Yes	Yes	No	9	8
88	7x34	E3.I417	Shared	10.4951	24.0292	Yes	No	No	Yes	6	7
89	2x57	7x39	m2_on	1.32435	100	Yes	Yes	Yes	Yes	9	9
90	1x43	2x57	m2_on	4.01101	11.059	No	No	Yes	Yes	8	9
91	1x46	2x57	m2_on	7.9888	97.3402	No	No	Yes	Yes	8	9
92	1x46	1x50	m2_on	0	93.7492	No	No	No	Yes	8	9
93	1x50	7x50	m2_on	1.5332	50.8217	No	Yes	No	No	9	9
94	1x49	7x50	m2_on	0	38.308	No	No	No	No	9	9
95	1x49	1x52	m2_on	0	36.689	No	No	No	No	9	8
96	1x52	8x54	m2_on	7.6138	31.759	No	No	No	No	8	9
97	1x53	7x50	m2_on	0	12.8606	No	No	No	No	9	9
98	1x56	8x50	m2_on	0	21.6859	No	No	Yes	No	9	9
99	2x46	2x50	m2_on	0	60.28	No	Yes	Yes	Yes	9	9
100	2x46	3x43	m2_on	0	58.4723	No	Yes	No	No	9	9
101	3x43	7x53	m2_on	0	57.4194	No	No	No	Yes	9	9
102	3x46	7x53	m2_on	0	41.1869	No	No	No	Yes	9	9
103	3x49	I2x57	m2_on	6.76413	21.2051	No	Yes	Yes	Yes	9	8
104	2x38	I2x57	m2_on	1.83225	10.4747	No	No	Yes	Yes	7	8
105	3x37	4x53	m2_on	1.85598	20.9921	No	Yes	No	No	9	9
106	3x38	4x53	m2_on	0	10.6452	No	No	No	No	8	9
107	2x60	7x39	m2_on	2.72464	47.8393	Yes	Yes	Yes	Yes	8	9
108	2x60	3x28	m2_on	4.71828	47.5533	Yes	Yes	Yes	Yes	8	7
109	7x38	7x42	m2_on	0	21.6616	No	Yes	Yes	Yes	7	9
110	2x63	E1x50	m2_on	1.8275	15.3682	No	No	Yes	Yes	7	9
111	2x63	E2.E175	m2_on	0	12.8363	No	No	No	No	7	5
112	3x28	3x29	m2_on	0	15.0213	Yes	Yes	No	No	7	7
113	3x29	E2x52	m2_on	4.59012	20.4747	No	No	Yes	Yes	7	7
114	3x33	7x38	m2_on	0	27.0237	Yes	Yes	No	Yes	8	7
115	3x50	7x53	m2_on	0	12.538	Yes	No	No	Yes	9	9
116	3x50	5x58	m2_on	0	26.2203	Yes	No	No	Yes	9	9
117	3x47	5x58	m2_on	0	25.5021	No	No	No	Yes	9	9
118	3x47	5x57	m2_on	5.43504	22.8119	No	No	Yes	No	9	8
119	3x56	I2x53	m2_on	0	12.8058	No	No	Yes	Yes	7	9
120	4x57	4x61	m2_on	3.39868	12.4041	Yes	Yes	Yes	No	8	8
121	3x30	4x61	m2_on	2.51104	10.493	No	No	Yes	No	8	8
122	5x47	6x48	m2_on	9.5932	10.0243	Yes	Yes	Yes	Yes	9	9
123	5x47	5x48	m2_on	5.00783	15.6056	Yes	Yes	Yes	No	9	8
124	5x48	6x56	m2_on	7.63279	11.7468	Yes	No	No	No	8	7
125	6x44	6x48	m2_on	1.71358	35.8186	Yes	No	Yes	Yes	9	9
126	5x51	6x44	m2_on	0	40.6634	No	No	Yes	No	7	9
127	5x51	5x52	m2_on	0	36.7681	No	No	No	No	7	5
128	5x52	5x56	m2_on	1.84649	35.983	No	No	No	No	5	5
129	5x55	5x56	m2_on	0	35.5752	No	No	No	No	6	5
130	5x55	6x41	m2_on	0	35.2161	No	No	No	No	6	8
131	7x34	7x38	m2_on	0	32.4772	Yes	No	No	Yes	6	7
132	7x30	E3.I417	m2_on	0	15.5873	No	No	No	Yes	7	7
133	7x30	7x33	m2_on	1.56643	13.3962	No	No	No	No	7	5
134	6x54	7x33	m2_on	3.12337	11.1929	Yes	No	No	No	7	5
135	5x58	6x41	m2_on	0	34.9239	No	Yes	No	No	9	8
136	3x46	3x50	m2_on	0	13.9988	No	No	Yes	No	9	9
137	3x33	4x57	m2_on	2.25946	12.2763	Yes	Yes	Yes	Yes	8	8

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
2x53	2x56	m2_off	5.67333	0	1	0	2	2
2x53	7x42	m2_off	5.64	0	1	0	2	1
2x56	3x28	m2_off	3.70667	0	1	1	2	2
2x56	3x32	Shared	9.81667	10.31	1	1	2	1
2x56	7x42	Shared	9.32333	6.36	1	1	2	1
2x57	7x39	Shared	7.36667	11.63	1	0	2	2
2x57	7x42	m2_off	4.79	0	1	0	2	1
2x60	3x28	Shared	4.17667	4.82	1	1	2	2
2x60	7x38	Shared	18.5333	9.93	1	1	2	1
2x60	7x39	Shared	6.43	5.79	1	1	2	2
2x60	7x42	Shared	3.97333	4.96	1	1	2	1
3x28	3x32	m2_off	3.72	0	1	0	2	1
3x32	7x42	Shared	8.81333	8.05	1	1	1	1
3x32	Lig	Shared	8.93	5.93	1	1	1	0
3x33	4x57	Shared	15.43	13.5	1	1	1	1
3x33	4x61	m2_off	4.03333	0	1	1	1	2
3x33	E2x52	Shared	8.86333	12.09	1	1	1	2
3x33	E2.F181	m2_off	6.53667	0	1	1	1	2
3x33	Lig	Shared	19.11	13.32	1	1	1	0
3x36	6x48	m2_off	4.94333	0	1	0	1	1
3x36	Lig	Shared	10.75	7.87	1	0	1	0
3x37	4x57	Shared	9.04	10.17	0	1	2	1
3x39	6x44	m2_off	3.56667	0	1	0	2	2
3x39	6x48	m2_off	5.33333	0	1	0	2	1
3x39	7x45	m2_off	5.62667	0	1	0	2	2
4x57	4x61	Shared	3.52333	3.52	1	1	1	2
4x57	5x43	Shared	3.64	8.49	1	1	1	2
4x57	Lig	Shared	3.61333	5.97	1	1	1	0
4x61	E2x52	m2_off	6.87	0	1	0	2	2
E2.F181	E2x52	Shared	15.4867	3.77	1	0	2	2
5x43	E2.F181	m2_off	7.78	0	0	0	2	2
5x461	Lig	m2_off	5.28667	0	0	0	1	0
5x47	5x48	Shared	7.90667	8.25	1	1	2	2
5x47	6x44	Shared	4.29	5.36	1	1	2	2
5x47	6x48	Shared	4.67667	4.01	1	1	2	1
5x47	6x52	Shared	24.9733	14.5	1	1	2	1
5x48	6x52	m2_off	3.49	0	1	0	2	1
6x44	6x48	Shared	17.7067	10.02	1	1	2	1
6x44	7x45	m2_off	4.02667	0	1	1	2	2
6x47	6x48	Shared	4.85	6.06	1	1	2	1
6x47	7x45	Shared	9.75	11.7	1	1	2	2
6x48	7x41	m2_off	16.1067	0	1	1	1	1
6x48	7x45	Shared	8.66333	13.56	1	1	1	2
6x48	Lig	Shared	10.43	8.96	1	1	1	0
6x51	6x55	Shared	5.05	5.05	1	1	1	2
6x51	7x34	m2_off	5.78667	0	1	1	1	2
6x51	7x38	Shared	7.94333	5.96	1	1	1	1
6x51	Lig	Shared	16.9067	10.24	1	1	1	0
6x52	Lig	m2_off	10.2367	0	1	0	1	0
7x38	Lig	Shared	12.58	7.17	1	1	1	0
7x39	7x42	Shared	4.18	8.68	1	1	2	1
7x41	Lig	Shared	4.95667	5.55	1	1	1	0
7x42	Lig	Shared	5.38	5.12	1	1	1	0
5x44	Lig	m2_off	2.29	0	0	0	1	0
2x53	3x36	m2_on	0	4.64	1	0	2	1
3x33	6x51	m2_on	0	4.96	1	1	1	1
3x33	7x38	m2_on	0	5.96	1	1	1	1
3x37	4x56	m2_on	0	4.12	0	1	2	2
3x40	6x48	m2_on	0	6.13	0	0	2	1
4x56	4x57	m2_on	0	9.11	0	1	2	1
6x51	6x52	m2_on	0	4.65	1	1	1	1
6x51	7x41	m2_on	0	4.03	1	1	1	1
7x34	7x38	m2_on	0	7.72	1	1	2	1
7x38	7x42	m2_on	0	4.96	1	1	1	1
5x44	6x52	m2_on	0	1.56	0	0	1	1
4x57	5x461	m2_on	0	1.3	1	1	1	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	m2_off	5ZKB-M₂-AF-DX 384 5ZKC-M₂-N-Methyl Scopolamine 5ZK3-M₂-Quinuclidinyl benzilate hydrobromide
	m2_on	7T8X-M₂-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2

Network Difference
Value	m2_off	m2_on
I_min	3.47333	3.39
Number of Linked Nodes	275	256
Number of Specific Nodes	24 (8.73%)	5 (1.95%)
Number of Shared Nodes	251 (91.27%)	251 (98.05%)
Number of Links	312	277
Number of Specific Links	139 (44.55%)	104 (37.55%)
Number of Shared Links	173 (55.45%)	173 (62.45%)
Number of Hubs	41	31
Number of Specific Hubs	20 (48.78%)	10 (32.26%)
Number of Shared Hubs	21 (51.22%)	21 (67.74%)
Average % Shared Neighbours (Jaccard)	43.06
Average % Shared Neighbours (Otsuka)	52.66
Average % Shared Neighbours (Overlap Coefficient)	62.54
Average % Shared Cliques (k3-6)	54.89
Graphlets Similarity	0.674335

Paths Difference
Value	m2_off	m2_on
Number Of Nodes in MetaPath	84	68
Specific Nodes in MetaPath	42 (50.00%)	26 (38.24%)
Shared Nodes in MetaPath	251 (91.27%)	251 (91.27%)
Number Of Links MetaPath	88	74
Specific Links in MetaPath	63 (71.59%)	49 (66.22%)
Shared Links in MetaPath	173 (55.45%)	173 (55.45%)
Number of Shortest Paths	53869	40868
Length Of Smallest Path	3	3
Average Path Length	15.2395	12.8347
Length of Longest Path	38	26
Minimum Path Strength	0.958333	1.34
Average Path Strength	6.70545	5.90057
Maximum Path Strength	18.1067	13.91
Minimum Path Correlation	0.7	0.7
Average Path Correlation	0.919469	0.933502
Maximum Path Correlation	0.993333	0.99
Minimum % Of Corr. Nodes	3.22581	5.26316
Average % Of Corr. Nodes	42.5478	55.6466
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	43.33	46.8997
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

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