psnGPCR

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Orange: nodes, hubs and links specific of m2_on_allo network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of m2_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	m2_on_allo Int. Strength	m2_on Int. Strength	m2_on_allo Hub1?	m2_on Hub1?	m2_on_allo Hub2?	m2_on Hub2?	ConSurf1	ConSurf2
1	1x57	I1x51	m2_on_allo	3.43	0	No	No	No	No	8	8
2	1x60	8x53	m2_on_allo	5.115	0	No	No	No	No	8	8
3	I1x48	I1x51	m2_on_allo	8.76	0	No	No	No	No	8	8
4	2x40	I1x50	m2_on_allo	4.12	0	No	No	Yes	No	9	9
5	8x53	I1x50	m2_on_allo	5.9	0	No	No	Yes	No	8	9
6	2x41	I1x51	m2_on_allo	7.89	0	No	No	No	No	8	8
7	2x45	4x46	m2_on_allo	7.74	0	No	No	No	No	9	9
8	2x46	3x42	m2_on_allo	5.495	0	No	Yes	No	No	9	9
9	2x52	3x31	m2_on_allo	3.565	0	No	No	No	No	8	6
10	2x53	2x56	m2_on_allo	6.19	0	No	No	Yes	No	8	8
11	2x53	7x42	m2_on_allo	5.44	0	No	No	Yes	Yes	8	9
12	2x57	7x42	m2_on_allo	6.585	0	Yes	Yes	Yes	Yes	9	9
13	2x60	2x63	m2_on_allo	3.97	0	Yes	Yes	Yes	No	8	7
14	2x60	Allo1	m2_on_allo	6.895	0	Yes	Yes	Yes	No	8	0
15	2x62	2x66	m2_on_allo	3.57	0	No	No	Yes	No	5	6
16	2x63	Allo1	m2_on_allo	6.46	0	Yes	No	Yes	No	7	0
17	2x66	E1x49	m2_on_allo	6.045	0	Yes	No	No	No	6	4
18	E1x49	E1x51	m2_on_allo	6.955	0	No	No	No	No	4	4
19	E1x50	E1x52	m2_on_allo	9.68	0	Yes	Yes	No	No	9	8
20	3x29	3x33	m2_on_allo	4.1	0	No	No	Yes	Yes	7	8
21	3x31	3x35	m2_on_allo	3.725	0	No	No	No	No	6	7
22	3x37	Lig	m2_on_allo	4.03	0	Yes	Yes	Yes	Yes	9	0
23	3x40	6x44	m2_on_allo	3.93	0	No	No	Yes	No	9	9
24	3x44	5x50	m2_on_allo	3.285	0	No	No	No	No	7	9
25	4x40	4x44	m2_on_allo	7.92	0	No	No	No	No	5	4
26	4x46	4x50	m2_on_allo	3.525	0	No	No	No	Yes	9	9
27	4x59	4x63	m2_on_allo	3.61	0	No	No	No	No	8	7
28	4x61	E2x52	m2_on_allo	3.68	0	Yes	No	No	Yes	8	7
29	4x61	E2.Q179	m2_on_allo	3.43	0	Yes	No	No	No	8	7
30	4x64	4x67	m2_on_allo	4.7	0	Yes	Yes	No	No	6	5
31	E2.V171	E2x51	m2_on_allo	13.88	0	No	No	No	No	4	4
32	7x31	E2.E175	m2_on_allo	4.6	0	No	No	Yes	No	4	5
33	Allo1	E2x51	m2_on_allo	22.84	0	Yes	No	No	No	0	4
34	Allo1	E2.F181	m2_on_allo	15.225	0	Yes	No	No	No	0	5
35	5x40	5x41	m2_on_allo	5.19	0	No	No	No	Yes	8	7
36	5x40	6x59	m2_on_allo	10.205	0	No	No	No	No	8	7
37	5x44	6x56	m2_on_allo	3.94	0	No	No	No	No	8	7
38	5x461	Lig	m2_on_allo	4.185	0	No	No	Yes	Yes	8	0
39	5x54	6x41	m2_on_allo	3.535	0	No	No	No	No	9	8
40	5x54	6x44	m2_on_allo	3.735	0	No	No	Yes	No	9	9
41	6x27	6x32	m2_on_allo	3.345	0	No	No	No	No	4	9
42	6x58	Allo1	m2_on_allo	3.535	0	Yes	No	Yes	No	4	0
43	7x33	E3.I417	m2_on_allo	3.84	0	Yes	No	Yes	Yes	5	7
44	7x31	7x34	m2_on_allo	5.65	0	No	No	Yes	No	4	6
45	7x31	Allo1	m2_on_allo	12.62	0	No	No	Yes	No	4	0
46	7x34	Allo1	m2_on_allo	56.52	0	Yes	No	Yes	No	6	0
47	7x35	7x39	m2_on_allo	4.85	0	No	No	Yes	Yes	6	9
48	7x38	Allo1	m2_on_allo	3.445	0	Yes	Yes	Yes	No	7	0
49	7x45	7x49	m2_on_allo	8.855	0	Yes	No	Yes	No	9	9
50	8x47	8x50	m2_on_allo	7.245	0	No	No	Yes	No	9	9
51	8x52	8x53	m2_on_allo	3.755	0	No	No	No	No	6	8
52	1x53	8x50	m2_on_allo	3.275	0	No	No	Yes	No	9	9
53	2x58	2x59	m2_on_allo	3.435	0	No	No	No	No	9	7
54	2x64	Allo1	m2_on_allo	3.25	0	No	No	Yes	No	7	0
55	E2.E172	E2.E175	m2_on_allo	5.71	0	No	No	Yes	No	1	5
56	6x58	E2.F181	m2_on_allo	6.04	0	Yes	No	No	No	4	5
57	5x66	5x68	m2_on_allo	4.33	0	No	No	No	No	7	8
58	8x56	8x57	m2_on_allo	4.5	0	No	No	No	No	0	0
59	2x50	3x39	m2_on_allo	2.945	0	Yes	Yes	No	No	9	9
60	2x43	7x53	m2_on_allo	2.93	0	No	No	Yes	Yes	8	9
61	4x65	E2.R169	m2_on_allo	2.92	0	No	No	No	No	7	8
62	3x21	E1x50	m2_on_allo	2.81	0	No	No	Yes	Yes	7	9
63	5x56	5x60	m2_on_allo	2.77	0	No	No	No	No	5	6
64	E2.F181	E2.S182	m2_on_allo	2.64	0	No	No	No	No	5	6
65	2x551	2x56	m2_on_allo	2.64	0	No	No	Yes	No	5	8
66	7x30	7x32	m2_on_allo	2.625	0	No	No	No	No	7	4
67	4x54	4x55	m2_on_allo	2.51	0	No	No	No	No	5	5
68	1x34	1x35	m2_on_allo	2.51	0	No	No	No	No	3	6
69	5x49	5x50	m2_on_allo	2.46	0	No	No	No	No	7	9
70	7x49	7x50	m2_on_allo	2.445	0	Yes	No	No	No	9	9
71	7x55	8x50	m2_on_allo	2.435	0	No	No	Yes	No	7	9
72	3x33	4x61	m2_on_allo	2.42	0	Yes	Yes	Yes	No	8	8
73	1x54	2x47	m2_on_allo	2.415	0	No	No	No	No	7	9
74	1x55	1x59	m2_on_allo	2.405	0	No	No	No	No	6	7
75	1x50	2x47	m2_on_allo	2.345	0	No	Yes	No	No	9	9
76	5x67	5x70	m2_on_allo	2.295	0	No	No	No	No	6	6
77	6x28	6x32	m2_on_allo	2.295	0	No	No	No	No	5	9
78	6x31	6x34	m2_on_allo	2.25	0	No	No	No	No	7	8
79	1x41	1x42	m2_on_allo	2.25	0	No	No	No	No	5	6
80	1x59	8x57	m2_on_allo	2.235	0	No	No	No	No	7	0
81	1x44	1x47	m2_on_allo	2.14	0	No	No	Yes	No	6	7
82	7x45	7x48	m2_on_allo	2.125	0	Yes	No	No	No	9	6
83	5x65	6x29	m2_on_allo	1.98	0	No	No	No	No	8	7
84	1x33	1x34	m2_on_allo	1.965	0	No	No	No	No	6	3
85	5x47	5x51	m2_on_allo	1.965	0	Yes	Yes	No	No	9	7
86	4x64	5x37	m2_on_allo	1.945	0	Yes	Yes	No	No	6	4
87	1x40	1x43	m2_on_allo	1.86	0	No	No	No	No	4	8
88	I2x53	I2x56	m2_on_allo	1.79	0	Yes	Yes	No	No	9	6
89	1x47	2x54	m2_on_allo	1.76	0	Yes	No	No	No	7	8
90	1x48	1x49	m2_on_allo	1.76	0	No	No	No	No	5	9
91	3x54	5x64	m2_on_allo	1.7	0	No	No	No	No	8	7
92	I2x50	I2x51	m2_on_allo	1.64	0	No	No	No	No	9	7
93	6x40	7x52	m2_on_allo	1.635	0	No	No	No	No	9	9
94	3x41	4x49	m2_on_allo	1.61	0	No	No	No	No	8	8
95	3x54	3x55	m2_on_allo	1.585	0	No	No	No	No	8	8
96	5x62	6x37	m2_on_allo	1.55	0	No	No	No	No	8	9
97	7x33	7x36	m2_on_allo	1.535	0	Yes	No	No	No	5	5
98	1x55	1x58	m2_on_allo	1.52	0	No	No	No	No	6	5
99	5x52	5x55	m2_on_allo	1.52	0	No	No	No	No	5	6
100	3x23	3x27	m2_on_allo	1.49	0	No	No	No	No	4	6
101	1x47	1x48	m2_on_allo	1.47	0	Yes	No	No	No	7	5
102	1x47	1x51	m2_on_allo	1.47	0	Yes	No	No	No	7	6
103	6x57	E3.I417	m2_on_allo	1.47	0	No	No	Yes	Yes	7	7
104	4x40	4x41	m2_on_allo	1.44	0	No	No	No	No	5	8
105	5x65	6x30	m2_on_allo	1.435	0	No	No	No	No	8	9
106	7x40	7x43	m2_on_allo	1.425	0	No	No	No	No	8	6
107	5x47	6x49	m2_on_allo	1.385	0	Yes	Yes	No	No	9	7
108	1x35	7x39	m2_on_allo	1.175	0	No	No	Yes	Yes	6	9
109	1x30	1x34	m2_on_allo	1.07	0	No	No	No	No	0	3
110	4x42	4x43	m2_on_allo	0.975	0	No	No	No	No	8	4
111	4x68	4x69	m2_on_allo	0.92	0	Yes	No	No	No	4	5
112	1x41	1x45	m2_on_allo	0.81	0	No	No	No	No	5	5
113	1x38	1x41	m2_on_allo	0.81	0	No	No	No	No	4	5
114	8x48	8x51	m2_on_allo	0.805	0	No	No	No	No	5	9
115	4x68	E2.T170	m2_on_allo	0.795	0	Yes	No	No	No	4	5
116	E2.T170	E2.V171	m2_on_allo	0.795	0	No	No	No	No	5	4
117	1x45	7x47	m2_on_allo	0.795	0	No	No	No	No	5	7
118	5x46	5x49	m2_on_allo	0.79	0	No	No	No	No	6	7
119	4x56	5x46	m2_on_allo	0.79	0	No	No	No	No	8	6
120	4x38	4x39	m2_on_allo	0.785	0	No	No	No	No	9	5
121	5x36	5x38	m2_on_allo	0.78	0	No	No	No	No	7	4
122	1x36	1x37	m2_on_allo	0.745	0	No	No	No	No	5	4
123	6x45	6x46	m2_on_allo	0.735	0	No	No	No	No	7	5
124	6x28	6x30	m2_on_allo	0.72	0	No	No	No	No	5	9
125	5x48	6x53	m2_on_allo	0.63	0	Yes	No	No	No	8	7
126	6x32	6x35	m2_on_allo	0.62	0	No	No	No	No	9	8
127	1x39	2x61	Shared	3.355	5.03	No	No	No	No	7	7
128	1x43	2x57	Shared	4.6	3.07	No	No	Yes	Yes	8	9
129	1x46	2x57	Shared	4.515	4.52	No	No	Yes	Yes	8	9
130	1x46	7x47	Shared	10.99	4.71	No	No	No	No	8	7
131	1x49	1x52	Shared	4.275	3.42	No	No	No	No	9	8
132	1x50	7x50	Shared	4.075	3.26	No	Yes	No	No	9	9
133	1x57	2x44	Shared	7.535	7.54	No	No	Yes	Yes	8	7
134	1x60	I1x49	Shared	4.465	6.38	No	No	No	No	8	6
135	1x60	I1x50	Shared	4.805	4.12	No	No	Yes	No	8	9
136	8x49	I1x50	Shared	5.9	5.9	No	No	Yes	No	7	9
137	8x50	I1x50	Shared	10.96	18.27	Yes	No	Yes	No	9	9
138	2x37	2x40	Shared	4.385	4.39	No	No	No	No	8	9
139	2x39	3x49	Shared	6.735	6.73	No	No	Yes	Yes	9	9
140	2x42	3x45	Shared	4.395	3.77	Yes	Yes	No	No	8	8
141	2x42	3x46	Shared	3.14	3.77	Yes	Yes	No	No	8	9
142	2x42	3x49	Shared	4.775	5.97	Yes	Yes	Yes	Yes	8	9
143	2x42	4x42	Shared	3.465	2.77	Yes	Yes	No	No	8	8
144	2x42	4x46	Shared	4.4	3.77	Yes	Yes	No	No	8	9
145	2x45	3x42	Shared	8.195	8.94	No	No	No	No	9	9
146	2x46	2x50	Shared	4.75	6.79	No	Yes	Yes	Yes	9	9
147	2x46	7x49	Shared	7.55	8.24	No	Yes	Yes	No	9	9
148	2x50	7x46	Shared	8.83	10.31	Yes	Yes	No	No	9	9
149	2x50	7x49	Shared	6.73	12.12	Yes	Yes	Yes	No	9	9
150	2x52	3x35	Shared	6.145	3.07	No	No	No	No	8	7
151	2x54	2x57	Shared	3.495	5.24	No	No	Yes	Yes	8	9
152	2x55	2x551	Shared	6.555	3.93	No	No	No	No	5	5
153	2x551	3x31	Shared	4.87	2.44	No	No	No	No	5	6
154	2x56	3x32	Shared	7.365	10.31	Yes	No	No	No	8	9
155	2x56	7x42	Shared	6.995	6.36	Yes	No	Yes	Yes	8	9
156	2x59	3x28	Shared	6.83	9.11	No	No	No	Yes	7	7
157	2x60	7x38	Shared	14.395	9.93	Yes	Yes	Yes	Yes	8	7
158	2x60	7x39	Shared	4.34	5.79	Yes	Yes	Yes	Yes	8	9
159	2x63	E1x50	Shared	7.715	8.68	Yes	No	Yes	Yes	7	9
160	2x63	E2.E175	Shared	4.485	10.1	Yes	No	Yes	No	7	5
161	2x66	E1x51	Shared	4.235	3.39	Yes	No	No	No	6	4
162	E1x50	E1x51	Shared	3.375	5.4	Yes	Yes	No	No	9	4
163	3x25	E1x50	Shared	9.14	7.84	No	No	Yes	Yes	9	9
164	3x28	E1x50	Shared	5.625	8.43	No	Yes	Yes	Yes	7	9
165	E1x50	E2x50	Shared	4.57	9.14	Yes	Yes	No	No	9	9
166	3x21	3x22	Shared	4.06	4.06	No	No	No	No	7	4
167	3x25	E2x50	Shared	7.28	7.28	No	No	No	No	9	9
168	3x28	3x29	Shared	4.555	5.69	No	Yes	No	No	7	7
169	3x32	7x42	Shared	8.045	8.05	No	No	Yes	Yes	9	9
170	3x32	Lig	Shared	5.93	5.93	No	No	Yes	Yes	9	0
171	3x33	4x57	Shared	9.645	13.5	Yes	Yes	Yes	Yes	8	8
172	3x33	6x51	Shared	7.945	4.96	Yes	Yes	Yes	Yes	8	8
173	3x33	7x38	Shared	5.46	5.96	Yes	Yes	Yes	Yes	8	7
174	3x33	Lig	Shared	14.465	13.32	Yes	Yes	Yes	Yes	8	0
175	3x34	4x54	Shared	3.93	2.62	No	No	No	No	8	5
176	3x36	Lig	Shared	12.45	7.87	No	No	Yes	Yes	8	0
177	3x37	3x41	Shared	3.505	8.41	Yes	Yes	No	No	9	8
178	3x37	4x53	Shared	8.195	4.47	Yes	Yes	No	No	9	9
179	3x37	4x57	Shared	7.91	10.17	Yes	Yes	Yes	Yes	9	8
180	3x38	4x50	Shared	7.78	7.78	No	No	No	Yes	8	9
181	3x43	7x53	Shared	8.795	5.86	No	No	Yes	Yes	9	9
182	3x44	3x48	Shared	6.7	4.87	No	No	No	No	7	7
183	3x45	4x45	Shared	5.835	2.92	No	No	No	No	8	8
184	3x46	3x50	Shared	6.89	6.26	No	No	No	No	9	9
185	3x46	7x53	Shared	4.835	6.04	No	No	Yes	Yes	9	9
186	3x47	5x54	Shared	3.835	3.07	No	No	No	No	9	9
187	3x47	5x57	Shared	3.755	6.01	No	No	No	No	9	8
188	3x47	5x58	Shared	8.905	5.09	No	No	Yes	Yes	9	9
189	3x48	5x53	Shared	3.14	3.77	No	No	No	No	7	7
190	3x48	5x57	Shared	6.09	4.87	No	No	No	No	7	8
191	3x49	I2x53	Shared	9.77	4.6	Yes	Yes	Yes	Yes	9	9
192	3x49	I2x57	Shared	8.93	14.29	Yes	Yes	Yes	Yes	9	8
193	3x50	5x58	Shared	7.2	7.2	No	No	Yes	Yes	9	9
194	3x50	7x53	Shared	7.2	5.14	No	No	Yes	Yes	9	9
195	3x51	3x52	Shared	4.125	6.19	Yes	Yes	No	No	9	6
196	3x51	3x55	Shared	11.235	16.23	Yes	Yes	No	No	9	8
197	3x51	5x57	Shared	5.275	7.03	Yes	Yes	No	No	9	8
198	3x51	5x60	Shared	7.075	6.53	Yes	Yes	No	No	9	6
199	3x51	5x61	Shared	4.835	3.63	Yes	Yes	No	No	9	9
200	3x52	I2x53	Shared	12.895	14.44	No	No	Yes	Yes	6	9
201	3x53	I2x53	Shared	4.03	4.03	No	No	Yes	Yes	8	9
202	I2x51	I2x52	Shared	3.685	1.47	No	No	No	No	7	6
203	I2x53	I2x57	Shared	13.89	13.38	Yes	Yes	Yes	Yes	9	8
204	4x54	4x58	Shared	4.16	8.32	No	No	No	No	5	6
205	4x56	4x57	Shared	3.985	9.11	No	No	Yes	Yes	8	8
206	4x57	5x43	Shared	9.705	8.49	Yes	Yes	No	No	8	9
207	4x57	5x461	Shared	3.24	1.3	Yes	Yes	No	No	8	8
208	4x57	Lig	Shared	4.65	5.97	Yes	Yes	Yes	Yes	8	0
209	4x64	4x68	Shared	4.29	2.45	Yes	Yes	Yes	No	6	4
210	4x64	E2.Q179	Shared	4.38	6.57	Yes	Yes	No	No	6	7
211	4x64	E2.F180	Shared	13.03	8.02	Yes	Yes	No	No	6	7
212	4x64	5x36	Shared	5.085	6.78	Yes	Yes	No	No	6	7
213	4x65	4x66	Shared	9.37	10.54	No	No	No	No	7	6
214	E2.F180	E2x52	Shared	12.56	6.28	No	No	No	Yes	7	7
215	5x39	E2.F180	Shared	3.93	5.24	No	No	No	No	8	7
216	5x41	6x56	Shared	7.92	8.53	No	Yes	No	No	7	7
217	5x45	5x48	Shared	6.65	6.04	No	No	Yes	No	7	8
218	5x47	5x48	Shared	5.16	8.25	Yes	Yes	Yes	No	9	8
219	5x47	6x44	Shared	5.36	5.36	Yes	Yes	Yes	No	9	9
220	5x47	6x48	Shared	4.01	4.01	Yes	Yes	Yes	Yes	9	9
221	5x47	6x52	Shared	16.315	14.5	Yes	Yes	No	No	9	7
222	5x58	6x37	Shared	9.67	12.09	Yes	Yes	No	No	9	9
223	5x58	6x41	Shared	3.52	4.69	Yes	Yes	No	No	9	8
224	5x59	5x60	Shared	6.875	1.06	No	No	No	No	4	6
225	5x59	5x63	Shared	6	4	No	No	No	No	4	5
226	5x62	6x34	Shared	4.8	4.8	No	No	No	No	8	8
227	5x66	6x30	Shared	9.45	1.35	No	No	No	No	7	9
228	5x67	6x29	Shared	3.295	1.32	No	No	No	No	6	7
229	6x40	7x53	Shared	7.25	7.25	No	No	Yes	Yes	9	9
230	6x44	6x48	Shared	5.015	10.02	Yes	No	Yes	Yes	9	9
231	6x47	6x48	Shared	5.455	6.06	No	No	Yes	Yes	9	9
232	6x47	7x45	Shared	12.43	11.7	No	No	Yes	No	9	9
233	6x48	7x45	Shared	9.605	13.56	Yes	Yes	Yes	No	9	9
234	6x48	Lig	Shared	20.41	8.96	Yes	Yes	Yes	Yes	9	0
235	6x50	7x40	Shared	4.925	3.28	No	No	No	No	9	8
236	6x51	6x52	Shared	8.14	4.65	Yes	Yes	No	No	8	7
237	6x51	6x55	Shared	3.785	5.05	Yes	Yes	No	No	8	8
238	6x51	Lig	Shared	13.58	10.24	Yes	Yes	Yes	Yes	8	0
239	6x58	E3.I417	Shared	12.745	4.25	Yes	No	Yes	Yes	4	7
240	6x58	7x34	Shared	10.735	7.91	Yes	No	Yes	No	4	6
241	7x34	E3.I417	Shared	12.335	3.52	Yes	No	Yes	Yes	6	7
242	7x30	7x33	Shared	4.415	5.3	No	No	Yes	No	7	5
243	7x38	7x42	Shared	8.935	4.96	Yes	Yes	Yes	Yes	7	9
244	7x38	Lig	Shared	10.79	7.17	Yes	Yes	Yes	Yes	7	0
245	7x41	Lig	Shared	4.91	5.55	No	No	Yes	Yes	8	0
246	7x42	Lig	Shared	4.88	5.12	Yes	Yes	Yes	Yes	9	0
247	7x54	8x50	Shared	4.85	4.16	No	No	Yes	No	8	9
248	8x47	8x49	Shared	7.315	8.77	No	No	No	No	9	7
249	2x38	I2x57	Shared	5.23	5.23	No	No	Yes	Yes	7	8
250	3x22	E2.R169	Shared	5.045	11.53	No	No	No	No	4	8
251	5x36	5x39	Shared	5.175	5.91	No	No	No	No	7	8
252	5x65	6x33	Shared	4.04	6.46	No	No	No	No	8	8
253	6x59	6x60	Shared	4.54	3.89	No	No	No	No	7	7
254	6x61	E3.C416	Shared	3.64	3.64	No	No	No	No	0	0
255	8x52	8x55	Shared	5.03	20.11	No	No	No	No	6	0
256	3x25	3x26	Shared	3.11	3.11	No	No	No	No	9	7
257	1x58	2x44	Shared	3.1	3.72	No	No	Yes	Yes	5	7
258	3x24	E1x50	Shared	3.065	6.13	No	No	Yes	Yes	6	9
259	5x55	6x41	Shared	2.945	2.95	No	No	No	No	6	8
260	4x58	4x59	Shared	2.805	1.87	No	No	No	No	6	8
261	6x49	6x50	Shared	2.805	1.87	No	No	No	No	7	9
262	I2x53	I2x54	Shared	2.78	4.17	Yes	Yes	No	No	9	7
263	1x50	2x51	Shared	2.745	6.87	No	Yes	No	No	9	8
264	2x66	2x67	Shared	2.645	1.76	Yes	No	No	No	6	6
265	1x56	8x50	Shared	2.64	2.64	No	No	Yes	No	9	9
266	6x54	7x37	Shared	2.62	1.75	No	No	No	No	7	6
267	2x49	4x50	Shared	2.59	2.59	No	No	No	Yes	9	9
268	E2.D173	E2.G174	Shared	2.515	1.68	No	No	No	No	3	3
269	3x56	I2x50	Shared	2.51	1.67	No	No	No	No	7	9
270	1x54	2x44	Shared	2.49	6.22	No	No	Yes	Yes	7	7
271	4x41	I2x57	Shared	2.48	1.24	No	No	Yes	Yes	8	8
272	E2.E175	E2.G174	Shared	2.455	1.64	Yes	No	No	No	5	3
273	2x61	7x39	Shared	2.425	4.85	No	No	Yes	Yes	7	9
274	3x34	4x53	Shared	2.425	1.62	No	No	No	No	8	9
275	1x36	2x65	Shared	2.405	3.21	No	No	No	Yes	5	6
276	1x32	2x65	Shared	2.405	3.21	No	No	No	Yes	4	6
277	3x30	4x62	Shared	2.365	3.15	No	No	No	No	8	6
278	5x51	6x45	Shared	2.305	3.07	No	No	No	No	7	7
279	6x54	7x33	Shared	2.28	3.04	No	No	Yes	No	7	5
280	I2x52	I2x56	Shared	2.25	6.01	No	No	No	No	6	6
281	7x55	8x51	Shared	2.115	1.41	No	No	No	No	7	9
282	3x27	4x62	Shared	2.075	1.38	No	No	No	No	6	6
283	5x51	6x44	Shared	1.965	3.93	No	No	Yes	No	7	9
284	1x52	8x54	Shared	1.825	4.87	No	No	No	No	8	9
285	6x43	7x52	Shared	1.81	1.81	No	No	No	No	8	9
286	1x53	7x50	Shared	1.77	1.77	No	No	No	No	9	9
287	5x48	6x56	Shared	1.76	3.52	Yes	No	No	No	8	7
288	1x30	1x31	Shared	1.75	1.17	No	No	No	No	0	0
289	7x48	7x52	Shared	1.635	4.91	No	No	No	No	6	9
290	E3.C416	E3.I417	Shared	1.635	4.91	No	No	Yes	Yes	0	7
291	3x30	4x61	Shared	1.625	3.25	No	No	Yes	No	8	8
292	4x51	4x55	Shared	1.54	3.07	No	No	No	No	5	5
293	6x33	6x37	Shared	1.54	1.54	No	No	No	No	8	9
294	6x36	6x40	Shared	1.52	3.04	No	No	No	No	9	9
295	5x41	5x42	Shared	1.51	1.51	No	Yes	No	No	7	6
296	2x44	2x48	Shared	1.395	2.79	Yes	Yes	No	No	7	7
297	2x41	4x39	Shared	1.25	2.5	No	No	No	No	8	5
298	E3.A414	E3.P415	Shared	0.935	1.87	No	No	No	No	0	0
299	4x68	E2.V168	Shared	0.8	1.6	Yes	No	No	No	4	3
300	2x64	2x65	Shared	0.795	1.59	No	No	No	Yes	7	6
301	7x51	7x55	Shared	0.79	1.58	No	No	No	No	7	7
302	6x34	6x38	Shared	0.735	2.95	No	No	No	No	8	7
303	3x41	4x52	Shared	0.705	2.83	No	No	No	No	8	6
304	1x29	1x30	Shared	0.65	11.67	No	No	No	No	0	0
305	6x31	6x35	Shared	0.62	1.24	No	No	No	No	7	8
306	1x34	1x38	m2_on	0	5.24	No	No	No	No	3	4
307	1x42	7x39	m2_on	0	3.42	No	No	Yes	Yes	6	9
308	1x43	2x58	m2_on	0	5.96	No	No	No	No	8	9
309	1x46	1x50	m2_on	0	4.39	No	No	No	Yes	8	9
310	1x49	7x50	m2_on	0	4.06	No	No	No	No	9	9
311	1x50	2x50	m2_on	0	6.73	No	Yes	Yes	Yes	9	9
312	1x53	2x47	m2_on	0	3.39	No	No	No	No	9	9
313	1x56	8x54	m2_on	0	5.28	No	No	No	No	9	9
314	2x38	4x39	m2_on	0	4.76	No	No	No	No	7	5
315	2x45	4x50	m2_on	0	6.18	No	No	No	Yes	9	9
316	2x46	3x43	m2_on	0	4.15	No	Yes	No	No	9	9
317	2x53	2x54	m2_on	0	3.53	No	No	No	No	8	8
318	2x53	3x35	m2_on	0	6.14	No	No	No	No	8	7
319	2x53	3x36	m2_on	0	4.64	No	No	No	No	8	8
320	2x57	7x39	m2_on	0	11.63	Yes	Yes	Yes	Yes	9	9
321	2x60	3x28	m2_on	0	4.82	Yes	Yes	No	Yes	8	7
322	2x60	7x35	m2_on	0	6.24	Yes	Yes	No	No	8	6
323	2x60	7x42	m2_on	0	4.96	Yes	Yes	Yes	Yes	8	9
324	2x64	7x35	m2_on	0	4.71	No	No	No	No	7	6
325	3x24	E1x52	m2_on	0	10.43	No	No	No	No	6	8
326	3x26	4x65	m2_on	0	3.92	No	No	No	No	7	7
327	3x29	E2x50	m2_on	0	4.76	No	No	No	No	7	9
328	3x29	E2x52	m2_on	0	5.71	No	No	No	Yes	7	7
329	3x33	E2x52	m2_on	0	12.09	Yes	Yes	No	Yes	8	7
330	3x37	4x56	m2_on	0	4.12	Yes	Yes	No	No	9	8
331	3x38	4x53	m2_on	0	3.42	No	No	No	No	8	9
332	3x40	5x50	m2_on	0	3.53	No	No	No	No	9	9
333	3x40	6x48	m2_on	0	6.13	No	No	Yes	Yes	9	9
334	3x42	4x50	m2_on	0	3.39	No	No	No	Yes	9	9
335	3x53	I2x57	m2_on	0	4.18	No	No	Yes	Yes	8	8
336	3x56	I2x52	m2_on	0	9.01	No	No	No	No	7	6
337	4x38	4x40	m2_on	0	12.01	No	No	No	No	9	5
338	4x43	4x46	m2_on	0	3.53	No	No	No	No	4	9
339	4x57	4x61	m2_on	0	3.52	Yes	Yes	Yes	No	8	8
340	4x62	4x63	m2_on	0	4.87	No	No	No	No	6	7
341	E2.R169	E2.V171	m2_on	0	7.85	No	No	No	No	8	4
342	E2.Q179	E2.T170	m2_on	0	8.5	No	No	No	No	7	5
343	E2.F181	E2x52	m2_on	0	3.77	No	No	No	Yes	5	7
344	5x40	E2.F181	m2_on	0	3.89	No	No	No	No	8	5
345	5x41	6x59	m2_on	0	6.49	No	Yes	No	No	7	7
346	5x41	6x60	m2_on	0	5.36	No	Yes	No	No	7	7
347	5x49	5x53	m2_on	0	4.28	No	No	No	No	7	7
348	6x51	7x38	m2_on	0	5.96	Yes	Yes	Yes	Yes	8	7
349	6x51	7x41	m2_on	0	4.03	Yes	Yes	No	No	8	8
350	6x57	E3.C416	m2_on	0	6.55	No	No	No	No	7	0
351	7x30	E3.I417	m2_on	0	3.39	No	No	Yes	Yes	7	7
352	7x34	7x38	m2_on	0	7.72	Yes	No	Yes	Yes	6	7
353	7x39	7x42	m2_on	0	8.68	Yes	Yes	Yes	Yes	9	9
354	7x47	7x48	m2_on	0	4.56	No	No	No	No	7	6
355	7x55	8x54	m2_on	0	3.65	No	No	No	No	7	9
356	E2.E172	E2x51	m2_on	0	3.37	No	No	No	No	1	4
357	1x43	1x47	m2_on	0	3.1	No	No	Yes	No	8	7
358	5x67	5x69	m2_on	0	3.1	No	No	No	No	6	5
359	1x35	2x65	m2_on	0	3.07	No	No	No	Yes	6	6
360	1x47	2x55	m2_on	0	3.07	Yes	No	No	No	7	5
361	1x53	1x57	m2_on	0	3.07	No	No	No	No	9	8
362	3x54	5x61	m2_on	0	3.07	No	No	No	No	8	9
363	2x46	3x39	m2_on	0	3	No	Yes	No	No	9	9
364	1x38	1x42	m2_on	0	2.98	No	No	No	No	4	6
365	1x48	1x51	m2_on	0	2.94	No	No	No	No	5	6
366	E2.Q179	E2.V171	m2_on	0	2.87	No	No	No	No	7	4
367	1x42	7x43	m2_on	0	2.85	No	No	No	No	6	6
368	1x48	1x52	m2_on	0	2.85	No	No	No	No	5	8
369	6x42	6x46	m2_on	0	2.85	No	No	No	No	7	5
370	8x53	8x56	m2_on	0	2.74	No	No	No	No	8	0
371	4x63	4x67	m2_on	0	2.51	No	No	No	No	7	5
372	3x56	I2x53	m2_on	0	2.39	No	No	Yes	Yes	7	9
373	E2.E175	E2x51	m2_on	0	2.24	Yes	No	No	No	5	4
374	1x39	1x40	m2_on	0	1.95	No	No	No	No	7	4
375	6x25	6x26	m2_on	0	1.95	No	No	No	No	0	0
376	6x26	6x27	m2_on	0	1.95	No	No	No	No	0	4
377	7x36	7x37	m2_on	0	1.76	No	No	No	No	5	6
378	6x36	7x56	m2_on	0	1.69	No	No	No	No	9	9
379	5x37	6x59	m2_on	0	1.68	No	No	No	No	4	7
380	6x27	6x31	m2_on	0	1.67	No	No	No	No	4	7
381	1x55	1x56	m2_on	0	1.62	No	No	No	No	6	9
382	3x45	4x49	m2_on	0	1.62	No	No	No	No	8	8
383	6x45	6x49	m2_on	0	1.62	No	No	No	No	7	7
384	2x37	2x38	m2_on	0	1.59	No	No	No	No	8	7
385	2x61	2x65	m2_on	0	1.59	No	No	No	Yes	7	6
386	5x55	5x56	m2_on	0	1.59	No	No	No	No	6	5
387	2x43	7x54	m2_on	0	1.58	No	No	No	No	8	8
388	8x49	8x53	m2_on	0	1.57	No	No	No	No	7	8
389	5x44	6x52	m2_on	0	1.56	No	No	No	No	8	7
390	6x58	E3.A414	m2_on	0	1.56	Yes	No	No	No	4	0
391	8x47	8x48	m2_on	0	1.56	No	No	No	No	9	5
392	5x51	5x52	m2_on	0	1.54	No	No	No	No	7	5
393	5x52	5x56	m2_on	0	1.54	No	No	No	No	5	5
394	6x28	6x31	m2_on	0	1.53	No	No	No	No	5	7
395	6x53	6x54	m2_on	0	1.52	No	No	No	No	7	7
396	7x32	7x36	m2_on	0	1.52	No	No	No	No	4	5
397	4x38	4x41	m2_on	0	1.51	No	No	No	No	9	8
398	1x59	1x60	m2_on	0	1.48	No	No	No	No	7	8
399	2x67	E1x49	m2_on	0	1.45	No	No	No	No	6	4
400	5x69	5x70	m2_on	0	1.45	No	No	No	No	5	6
401	4x41	4x44	m2_on	0	1.44	No	No	No	No	8	4
402	6x30	6x34	m2_on	0	1.41	No	No	No	No	9	8
403	5x68	5x69	m2_on	0	1.25	No	No	No	No	8	5

Orange: nodes, hubs and links specific of m2_on_allo network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of m2_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	m2_on_allo Avg Int. Strength	m2_on Avg Int. Strength	m2_on_allo Num Of Links	m2_on Num Of Links	ConSurf
1	1x47	m2_on_allo	1.71	3.085	4	2	7
2	I1x50	m2_on_allo	6.337	9.43	5	3	9
3	2x56	m2_on_allo	5.7975	8.335	4	2	8
4	2x63	m2_on_allo	5.6575	9.39	4	2	7
5	2x66	m2_on_allo	4.12375	2.575	4	2	6
6	4x61	m2_on_allo	2.78875	3.385	4	2	8
7	4x68	m2_on_allo	1.70125	2.025	4	2	4
8	E2.E175	m2_on_allo	4.3125	4.66	4	3	5
9	5x48	m2_on_allo	3.55	5.93667	4	3	8
10	6x44	m2_on_allo	4.001	6.43667	5	3	9
11	6x58	m2_on_allo	8.26375	4.57333	4	3	4
12	7x33	m2_on_allo	3.0175	4.17	4	2	5
13	7x34	m2_on_allo	21.31	6.38333	4	3	6
14	7x45	m2_on_allo	8.25375	12.63	4	2	9
15	7x49	m2_on_allo	6.395	10.18	4	2	9
16	8x50	m2_on_allo	5.23417	8.35667	6	3	9
17	Allo1	m2_on_allo	14.5322	0	9	0	0
18	2x42	Shared	4.035	4.01	5	5	8
19	2x44	Shared	3.63	5.0675	4	4	7
20	2x50	Shared	5.81375	8.9875	4	4	9
21	2x57	Shared	4.79875	6.115	4	4	9
22	2x60	Shared	7.4	6.348	4	5	8
23	E1x50	Shared	5.7475	7.60333	8	6	9
24	3x33	Shared	7.33917	9.966	6	5	8
25	3x37	Shared	5.91	6.7925	4	4	9
26	3x49	Shared	7.5525	7.8975	4	4	9
27	3x51	Shared	6.509	7.922	5	5	9
28	I2x53	Shared	7.52583	7.16833	6	6	9
29	I2x57	Shared	7.6325	7.664	4	5	8
30	4x57	Shared	6.5225	7.43714	6	7	8
31	4x64	Shared	5.57167	5.955	6	4	6
32	5x47	Shared	5.69917	8.03	6	4	9
33	5x58	Shared	7.32375	7.2675	4	4	9
34	6x48	Shared	8.899	8.12333	5	6	9
35	6x51	Shared	8.3625	5.815	4	6	8
36	E3.I417	Shared	6.405	4.0175	5	4	7
37	7x38	Shared	8.605	6.95	5	6	7
38	7x39	Shared	3.1975	6.874	4	5	9
39	7x42	Shared	6.81333	6.355	6	6	9
40	7x53	Shared	6.202	6.0725	5	4	9
41	Lig	Shared	9.11636	7.79222	11	9	0
42	1x50	m2_on	3.055	5.3125	3	4	9
43	2x46	m2_on	5.93167	5.545	3	4	9
44	2x65	m2_on	1.86833	2.534	3	5	6
45	3x28	m2_on	5.67	7.0125	3	4	7
46	4x50	m2_on	4.63167	4.985	3	4	9
47	E2x52	m2_on	8.12	6.9625	2	4	7
48	5x41	m2_on	4.87333	5.4725	3	4	7

Orange: nodes, hubs and links specific of m2_on_allo network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of m2_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	m2_on_allo Recurrence	m2_on Recurrence	m2_on_allo Hub1?	m2_on Hub1?	m2_on_allo Hub2?	m2_on Hub2?	ConSurf1	ConSurf2
1	2x57	7x42	m2_on_allo	18.0417	0	Yes	Yes	Yes	Yes	9	9
2	6x48	7x45	m2_on_allo	50.2648	1.6129	Yes	Yes	Yes	No	9	9
3	7x45	7x49	m2_on_allo	42.0441	0	Yes	No	Yes	No	9	9
4	7x49	7x50	m2_on_allo	33.8411	0	Yes	No	No	No	9	9
5	1x50	2x47	m2_on_allo	14.5511	0	No	Yes	No	No	9	9
6	1x54	2x47	m2_on_allo	13.5956	0	No	No	No	No	7	9
7	1x54	2x44	m2_on_allo	12.6342	1.86853	No	No	Yes	Yes	7	7
8	1x53	8x50	m2_on_allo	17.5063	0	No	No	Yes	No	9	9
9	5x54	6x44	m2_on_allo	62.47	0	No	No	Yes	No	9	9
10	3x47	5x54	m2_on_allo	40.0266	1.7468	No	No	No	No	9	9
11	3x51	3x52	m2_on_allo	11.8799	6.64638	Yes	Yes	No	No	9	6
12	3x52	I2x53	m2_on_allo	11.2439	6.7255	No	No	Yes	Yes	6	9
13	5x54	6x41	m2_on_allo	22.5558	0	No	No	No	No	9	8
14	7x45	7x48	m2_on_allo	10.3653	0	Yes	No	No	No	9	6
15	2x46	7x49	m2_on_allo	11.6935	0.389531	No	Yes	Yes	No	9	9
16	2x46	3x42	m2_on_allo	11.1936	0	No	Yes	No	No	9	9
17	2x45	3x42	m2_on_allo	10.6168	0	No	No	No	No	9	9
18	2x45	4x46	m2_on_allo	10.0843	0	No	No	No	No	9	9
19	2x60	2x63	m2_on_allo	15.69	0	Yes	Yes	Yes	No	8	7
20	3x21	E1x50	m2_on_allo	11.7704	0	No	No	Yes	Yes	7	9
21	3x29	3x33	m2_on_allo	16.039	0	No	No	Yes	Yes	7	8
22	3x37	Lig	m2_on_allo	12.6697	0	Yes	Yes	Yes	Yes	9	0
23	3x33	4x61	m2_on_allo	17.8761	0	Yes	Yes	Yes	No	8	8
24	5x58	6x37	m2_on_allo	31.2143	5.34388	Yes	Yes	No	No	9	9
25	5x62	6x37	m2_on_allo	11.9272	0	No	No	No	No	8	9
26	5x62	6x34	m2_on_allo	10.2352	0.0182593	No	No	No	No	8	8
27	6x33	6x37	m2_on_allo	17.811	3.57273	No	No	No	No	8	9
28	5x65	6x33	m2_on_allo	16.3526	1.78941	No	No	No	No	8	8
29	5x65	6x30	m2_on_allo	10.0606	0	No	No	No	No	8	9
30	6x58	Allo1	m2_on_allo	10.0104	0	Yes	No	Yes	No	4	0
31	7x33	E3.I417	m2_on_allo	11.4451	0	Yes	No	Yes	Yes	5	7
32	7x38	Allo1	m2_on_allo	43.9905	0	Yes	Yes	Yes	No	7	0
33	2x63	Allo1	m2_on_allo	17.172	0	Yes	No	Yes	No	7	0
34	2x60	7x38	Shared	23.041	37.9124	Yes	Yes	Yes	Yes	8	7
35	7x38	Lig	Shared	56.2106	16.1229	Yes	Yes	Yes	Yes	7	0
36	6x48	Lig	Shared	100	48.8618	Yes	Yes	Yes	Yes	9	0
37	1x50	7x50	Shared	16.4443	50.8217	No	Yes	No	No	9	9
38	1x53	7x50	Shared	18.444	12.8606	No	No	No	No	9	9
39	6x44	6x48	Shared	59.3551	35.8186	Yes	No	Yes	Yes	9	9
40	3x47	5x57	Shared	21.5294	22.8119	No	No	No	No	9	8
41	3x51	5x57	Shared	18.8996	16.1473	Yes	Yes	No	No	9	8
42	3x47	5x58	Shared	22.5706	25.5021	No	No	Yes	Yes	9	9
43	3x50	5x58	Shared	14.2316	26.2203	No	No	Yes	Yes	9	9
44	3x46	3x50	Shared	11.8444	13.9988	No	No	No	No	9	9
45	2x42	3x46	Shared	15.0954	53.4571	Yes	Yes	No	No	8	9
46	5x58	6x41	Shared	20.7573	34.9239	Yes	Yes	No	No	9	8
47	2x63	E1x50	Shared	24.9371	15.3682	Yes	No	Yes	Yes	7	9
48	3x28	E1x50	Shared	12.9567	35.9099	No	Yes	Yes	Yes	7	9
49	E1x50	E1x51	Shared	11.7704	10.2921	Yes	Yes	No	No	9	4
50	5x47	6x48	Shared	12.9212	10.0243	Yes	Yes	Yes	Yes	9	9
51	5x47	5x48	Shared	11.3563	15.6056	Yes	Yes	Yes	No	9	8
52	7x42	Lig	Shared	17.3465	44.1935	Yes	Yes	Yes	Yes	9	0
53	3x28	3x29	Shared	15.1782	15.0213	No	Yes	No	No	7	7
54	3x33	Lig	Shared	24.3692	21.0651	Yes	Yes	Yes	Yes	8	0
55	2x61	7x39	m2_on	1.979	13.0493	No	No	Yes	Yes	7	9
56	2x57	7x39	m2_on	0	100	Yes	Yes	Yes	Yes	9	9
57	1x43	2x57	m2_on	2.22748	11.059	No	No	Yes	Yes	8	9
58	1x46	2x57	m2_on	6.61736	97.3402	No	No	Yes	Yes	8	9
59	1x46	1x50	m2_on	0	93.7492	No	No	No	Yes	8	9
60	1x49	7x50	m2_on	0	38.308	No	No	No	No	9	9
61	1x49	1x52	m2_on	2.06774	36.689	No	No	No	No	9	8
62	1x50	2x50	m2_on	0	64.0414	No	Yes	Yes	Yes	9	9
63	1x52	8x54	m2_on	0.95548	31.759	No	No	No	No	8	9
64	1x56	8x54	m2_on	0	25.1309	No	No	No	No	9	9
65	1x56	8x50	m2_on	1.03239	21.6859	No	No	Yes	No	9	9
66	8x50	I1x50	m2_on	8.96317	16.4273	Yes	No	Yes	No	9	9
67	2x46	2x50	m2_on	0.263275	60.28	No	Yes	Yes	Yes	9	9
68	2x46	3x43	m2_on	0	58.4723	No	Yes	No	No	9	9
69	3x43	7x53	m2_on	1.0531	57.4194	No	No	Yes	Yes	9	9
70	3x46	7x53	m2_on	4.94897	41.1869	No	No	Yes	Yes	9	9
71	2x42	3x49	m2_on	9.13474	41.4729	Yes	Yes	Yes	Yes	8	9
72	3x49	I2x57	m2_on	1.29862	21.2051	Yes	Yes	Yes	Yes	9	8
73	2x38	I2x57	m2_on	0.87561	10.4747	No	No	Yes	Yes	7	8
74	7x39	7x42	m2_on	0	57.1272	Yes	Yes	Yes	Yes	9	9
75	4x57	Lig	m2_on	3.9787	33.6336	Yes	Yes	Yes	Yes	8	0
76	3x37	4x57	m2_on	1.70093	26.975	Yes	Yes	Yes	Yes	9	8
77	3x37	4x53	m2_on	9.67608	20.9921	Yes	Yes	No	No	9	9
78	3x38	4x53	m2_on	0	10.6452	No	No	No	No	8	9
79	2x60	7x39	m2_on	9.11699	47.8393	Yes	Yes	Yes	Yes	8	9
80	2x60	3x28	m2_on	0	47.5533	Yes	Yes	No	Yes	8	7
81	7x38	7x42	m2_on	8.86555	21.6616	Yes	Yes	Yes	Yes	7	9
82	2x63	E2.E175	m2_on	6.98713	12.8363	Yes	No	Yes	No	7	5
83	3x29	E2x52	m2_on	0	20.4747	No	No	No	Yes	7	7
84	E2.F180	E2x52	m2_on	2.32806	45.8065	No	No	No	Yes	7	7
85	4x64	E2.F180	m2_on	0.0917024	35.35	Yes	Yes	No	No	6	7
86	4x64	E2.Q179	m2_on	8.46916	21.3938	Yes	Yes	No	No	6	7
87	E2.Q179	E2.V171	m2_on	0	14.3092	No	No	No	No	7	4
88	E2.R169	E2.V171	m2_on	0	10.7486	No	No	No	No	8	4
89	3x33	7x38	m2_on	5.70626	27.0237	Yes	Yes	Yes	Yes	8	7
90	3x33	E2x52	m2_on	0	50	Yes	Yes	No	Yes	8	7
91	3x50	7x53	m2_on	1.343	12.538	No	No	Yes	Yes	9	9
92	3x49	I2x53	m2_on	4.09703	16.8168	Yes	Yes	Yes	Yes	9	9
93	3x56	I2x53	m2_on	0	12.8058	No	No	Yes	Yes	7	9
94	4x57	4x61	m2_on	0	12.4041	Yes	Yes	Yes	No	8	8
95	3x30	4x61	m2_on	4.56441	10.493	No	No	Yes	No	8	8
96	5x48	6x56	m2_on	8.0639	11.7468	Yes	No	No	No	8	7
97	5x51	6x44	m2_on	3.08534	40.6634	No	No	Yes	No	7	9
98	5x51	5x52	m2_on	0	36.7681	No	No	No	No	7	5
99	5x52	5x56	m2_on	0	35.983	No	No	No	No	5	5
100	5x55	5x56	m2_on	0	35.5752	No	No	No	No	6	5
101	5x55	6x41	m2_on	2.13282	35.2161	No	No	No	No	6	8
102	7x34	7x38	m2_on	0	32.4772	Yes	No	Yes	Yes	6	7
103	7x34	E3.I417	m2_on	9.20278	24.0292	Yes	No	Yes	Yes	6	7
104	7x30	E3.I417	m2_on	0	15.5873	No	No	Yes	Yes	7	7
105	7x30	7x33	m2_on	3.83671	13.3962	No	No	Yes	No	7	5
106	6x54	7x33	m2_on	3.83671	11.1929	No	No	Yes	No	7	5
107	3x33	4x57	m2_on	3.65035	12.2763	Yes	Yes	Yes	Yes	8	8

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
2x53	3x36	m2_on	4.64	0	0	1	2	1
2x56	3x32	Shared	10.31	7.365	1	1	2	1
2x56	7x42	Shared	6.36	6.995	1	1	2	1
2x57	7x39	m2_on	11.63	0	0	0	2	2
2x60	7x38	Shared	9.93	14.395	1	1	2	1
2x60	7x39	Shared	5.79	4.34	1	1	2	2
2x60	7x42	m2_on	4.96	0	1	1	2	1
3x29	E2x52	m2_on	5.71	0	0	0	2	2
3x32	7x42	Shared	8.05	8.045	1	1	1	1
3x32	Lig	Shared	5.93	5.93	1	1	1	0
3x33	4x57	Shared	13.5	9.645	1	1	1	1
3x33	E2x52	m2_on	12.09	0	1	1	1	2
3x33	6x51	Shared	4.96	7.945	1	1	1	1
3x33	7x38	Shared	5.96	5.46	1	1	1	1
3x33	Lig	Shared	13.32	14.465	1	1	1	0
3x36	Lig	Shared	7.87	12.45	0	0	1	0
3x37	3x41	Shared	8.41	3.505	1	1	1	2
3x37	4x53	Shared	4.47	8.195	1	1	1	2
3x37	4x56	m2_on	4.12	0	1	1	1	2
3x37	4x57	Shared	10.17	7.91	1	1	1	1
3x40	6x48	m2_on	6.13	0	0	0	2	1
4x56	4x57	Shared	9.11	3.985	1	0	2	1
4x57	4x61	m2_on	3.52	0	1	1	1	2
4x57	5x43	Shared	8.49	9.705	1	1	1	2
4x57	Lig	Shared	5.97	4.65	1	1	1	0
5x47	6x44	Shared	5.36	5.36	1	1	2	2
5x47	6x48	Shared	4.01	4.01	1	1	2	1
5x47	6x52	Shared	14.5	16.315	1	1	2	2
6x44	6x48	Shared	10.02	5.015	1	1	2	1
6x47	6x48	Shared	6.06	5.455	1	1	2	1
6x47	7x45	Shared	11.7	12.43	1	1	2	2
6x48	7x45	Shared	13.56	9.605	1	1	1	2
6x48	Lig	Shared	8.96	20.41	1	1	1	0
6x51	6x52	Shared	4.65	8.14	1	1	1	2
6x51	6x55	Shared	5.05	3.785	1	1	1	2
6x51	7x38	m2_on	5.96	0	1	1	1	1
6x51	7x41	m2_on	4.03	0	1	1	1	1
6x51	Lig	Shared	10.24	13.58	1	1	1	0
7x34	7x38	m2_on	7.72	0	1	1	2	1
7x38	7x42	Shared	4.96	8.935	1	1	1	1
7x38	Lig	Shared	7.17	10.79	1	1	1	0
7x39	7x42	m2_on	8.68	0	1	0	2	1
7x41	Lig	Shared	5.55	4.91	1	0	1	0
7x42	Lig	Shared	5.12	4.88	1	1	1	0
4x57	5x461	Shared	1.3	3.24	1	1	1	1
2x53	2x56	m2_on_allo	0	6.19	0	1	2	2
2x53	7x42	m2_on_allo	0	5.44	0	1	2	1
2x57	7x42	m2_on_allo	0	6.585	0	0	2	1
2x60	Allo1	m2_on_allo	0	6.895	1	1	2	2
3x29	3x33	m2_on_allo	0	4.1	0	0	2	1
3x37	Lig	m2_on_allo	0	4.03	1	1	1	0
3x40	6x44	m2_on_allo	0	3.93	0	0	2	2
4x61	E2x52	m2_on_allo	0	3.68	0	0	2	2
5x461	Lig	m2_on_allo	0	4.185	0	1	1	0
7x34	Allo1	m2_on_allo	0	56.52	1	1	2	2
7x38	Allo1	m2_on_allo	0	3.445	1	1	1	2
3x33	4x61	m2_on_allo	0	2.42	1	1	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	m2_on_allo	7T94-M₂-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M₂-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
	m2_on	7T8X-M₂-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2

Network Difference
Value	m2_on_allo	m2_on
I_min	3.135	3.39
Number of Linked Nodes	269	256
Number of Specific Nodes	18 (6.69%)	5 (1.95%)
Number of Shared Nodes	251 (93.31%)	251 (98.05%)
Number of Links	305	277
Number of Specific Links	126 (41.31%)	98 (35.38%)
Number of Shared Links	179 (58.69%)	179 (64.62%)
Number of Hubs	41	31
Number of Specific Hubs	17 (41.46%)	7 (22.58%)
Number of Shared Hubs	24 (58.54%)	24 (77.42%)
Average % Shared Neighbours (Jaccard)	45.44
Average % Shared Neighbours (Otsuka)	54.98
Average % Shared Neighbours (Overlap Coefficient)	64.64
Average % Shared Cliques (k3-6)	59.56
Graphlets Similarity	0.607404

Paths Difference
Value	m2_on_allo	m2_on
Number Of Nodes in MetaPath	53	68
Specific Nodes in MetaPath	20 (37.74%)	35 (51.47%)
Shared Nodes in MetaPath	251 (93.31%)	251 (93.31%)
Number Of Links MetaPath	54	74
Specific Links in MetaPath	33 (61.11%)	53 (71.62%)
Shared Links in MetaPath	179 (58.69%)	179 (58.69%)
Number of Shortest Paths	60097	40868
Length Of Smallest Path	3	3
Average Path Length	11.8109	12.8347
Length of Longest Path	24	26
Minimum Path Strength	0.62	1.34
Average Path Strength	6.41276	5.90057
Maximum Path Strength	39.68	13.91
Minimum Path Correlation	0.7	0.7
Average Path Correlation	0.925119	0.933502
Maximum Path Correlation	0.995	0.99
Minimum % Of Corr. Nodes	4.7619	5.26316
Average % Of Corr. Nodes	49.0435	55.6466
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	50.4874	46.8997
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download m2_on_ortoallo.zip<

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