psnGPCR

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Orange: nodes, hubs and links specific of m3_on network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of m3_off network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	m3_on Int. Strength	m3_off Int. Strength	m3_on Hub1?	m3_off Hub1?	m3_on Hub2?	m3_off Hub2?	ConSurf1	ConSurf2
1	1x37	1x41	m3_on	100	0	No	No	No	No	5	4
2	1x56	8x54	m3_on	100	0	No	No	Yes	No	9	9
3	1x57	1x58	m3_on	100	0	Yes	No	No	No	9	6
4	8x49	I1x49	m3_on	100	0	No	No	No	No	8	8
5	2x40	I1x50	m3_on	100	0	Yes	No	Yes	Yes	9	9
6	2x39	2x40	m3_on	100	0	No	No	Yes	No	9	9
7	2x39	I2x54	m3_on	100	0	No	No	No	No	9	8
8	2x42	4x45	m3_on	100	0	Yes	Yes	No	No	8	8
9	2x46	3x43	m3_on	100	0	No	No	No	No	9	9
10	2x46	7x49	m3_on	100	0	No	No	No	Yes	9	9
11	2x63	E1x50	m3_on	100	0	No	No	Yes	Yes	8	9
12	3x26	E2	m3_on	100	0	Yes	No	Yes	Yes	8	6
13	3x40	6x48	m3_on	100	0	No	No	Yes	Yes	9	9
14	3x43	7x53	m3_on	100	0	No	No	Yes	Yes	9	9
15	3x44	5x53	m3_on	100	0	No	No	No	No	8	8
16	3x46	3x50	m3_on	100	0	No	No	No	No	9	9
17	3x46	7x53	m3_on	100	0	No	No	Yes	Yes	9	9
18	3x47	5x57	m3_on	100	0	No	No	No	No	9	8
19	3x47	5x58	m3_on	100	0	No	No	Yes	No	9	9
20	3x50	5x58	m3_on	100	0	No	No	Yes	No	9	9
21	3x50	7x53	m3_on	100	0	No	No	Yes	Yes	9	9
22	3x51	5x57	m3_on	100	0	Yes	Yes	No	No	9	8
23	3x55	3x56	m3_on	100	0	No	No	No	No	8	8
24	3x55	5x64	m3_on	100	0	No	No	No	No	8	8
25	I2x54	I2x57	m3_on	100	0	No	No	Yes	Yes	8	9
26	4x56	4x57	m3_on	100	0	No	No	Yes	Yes	8	9
27	4x57	5x43	m3_on	100	0	Yes	Yes	No	No	9	9
28	4x67	4x68	m3_on	100	0	No	No	No	No	6	6
29	5x36	E2	m3_on	100	0	Yes	No	Yes	Yes	8	6
30	5x37	6x59	m3_on	100	0	No	No	Yes	No	6	8
31	5x40	6x59	m3_on	100	0	No	No	Yes	No	8	8
32	5x45	5x48	m3_on	100	0	No	No	Yes	No	7	8
33	5x55	6x41	m3_on	100	0	No	No	No	No	7	9
34	5x58	6x37	m3_on	100	0	Yes	No	No	No	9	9
35	5x58	6x40	m3_on	100	0	Yes	No	Yes	No	9	9
36	5x58	7x53	m3_on	100	0	Yes	No	Yes	Yes	9	9
37	5x59	5x63	m3_on	100	0	No	No	No	No	7	5
38	5x62	5x66	m3_on	100	0	Yes	No	No	No	7	7
39	5x66	6x30	m3_on	100	0	No	No	No	No	7	9
40	5x68	5x69	m3_on	100	0	No	No	No	No	8	7
41	6x30	6x31	m3_on	100	0	No	No	No	No	9	7
42	6x45	6x49	m3_on	100	0	No	No	Yes	No	8	8
43	6x51	6x52	m3_on	100	0	No	No	No	No	9	9
44	6x51	6x55	m3_on	100	0	No	No	No	No	9	8
45	6x58	E3	m3_on	100	0	No	No	Yes	Yes	7	6
46	7x34	7x35	m3_on	100	0	No	Yes	No	No	6	6
47	7x42	Lig	m3_on	100	0	Yes	Yes	Yes	Yes	9	0
48	7x55	8x54	m3_on	100	0	No	No	Yes	No	8	9
49	4x64	5x36	m3_on	100	0	No	No	Yes	No	6	8
50	8x55	8x59	m3_on	100	0	No	No	No	No	7	5
51	3x26	4x62	m3_on	33.3333	0	Yes	No	Yes	No	8	7
52	1x53	8x54	m3_on	33.3333	0	No	No	Yes	No	9	9
53	6x57	6x60	m3_on	33.3333	0	No	No	No	No	7	7
54	6x35	6x36	m3_on	66.6667	0	No	No	Yes	No	8	9
55	2x52	3x35	m3_on	0	0	No	No	No	No	8	8
56	2x53	3x35	m3_on	0	0	Yes	No	No	No	9	8
57	5x62	6x33	m3_on	33.3333	0	Yes	No	No	No	7	9
58	3x24	E1x52	m3_on	33.3333	0	No	No	No	No	7	8
59	1x30	1x31	m3_on	0	0	No	No	No	No	4	7
60	2x58	2x59	m3_on	33.3333	0	No	No	No	No	9	8
61	1x50	2x51	m3_on	33.3333	0	No	No	No	No	9	8
62	1x53	7x54	m3_on	0	0	No	No	No	No	9	9
63	5x44	5x48	m3_on	0	0	No	No	Yes	No	9	8
64	3x42	4x49	m3_on	33.3333	0	No	No	No	No	9	9
65	4x63	4x66	m3_on	0	0	No	No	No	No	7	5
66	5x68	5x72	m3_on	33.3333	0	No	No	No	No	8	6
67	1x57	2x40	m3_on	0	0	Yes	No	Yes	No	9	9
68	1x59	8x57	m3_on	33.3333	0	No	No	No	No	8	8
69	1x40	1x43	m3_on	0	0	No	No	No	No	7	8
70	3x21	3x24	m3_on	0	0	No	No	No	No	9	7
71	5x62	6x37	m3_on	0	0	Yes	No	No	No	7	9
72	8x57	8x58	m3_on	33.3333	0	No	No	No	No	8	9
73	5x67	5x71	m3_on	33.3333	0	No	No	No	No	7	7
74	6x54	7x37	m3_on	0	0	No	No	No	No	7	8
75	7x36	7x37	m3_on	0	0	No	No	No	No	6	8
76	2x38	4x42	m3_on	0	0	No	No	No	No	8	8
77	5x65	6x33	m3_on	0	0	No	Yes	No	No	9	9
78	3x34	4x53	m3_on	0	0	No	No	No	No	9	9
79	2x61	2x62	m3_on	0	0	No	No	No	No	9	7
80	6x36	6x40	m3_on	0	0	Yes	No	Yes	No	9	9
81	4x44	4x45	m3_on	0	0	No	No	No	No	5	8
82	6x32	6x36	m3_on	0	0	No	No	Yes	No	9	9
83	6x38	6x42	m3_on	0	0	No	No	No	No	9	6
84	I2x52	I2x56	m3_on	33.3333	0	No	No	No	No	7	7
85	8x53	8x57	m3_on	0	0	No	Yes	No	No	9	8
86	5x66	5x69	m3_on	0	0	No	No	No	No	7	7
87	8x55	8x58	m3_on	33.3333	0	No	No	No	No	7	9
88	3x23	3x26	m3_on	33.3333	0	No	No	Yes	No	5	8
89	5x62	6x34	m3_on	0	0	Yes	No	No	No	7	9
90	4x55	4x59	m3_on	0	0	No	No	No	No	6	9
91	4x43	4x46	m3_on	0	0	No	No	Yes	No	5	9
92	8x56	8x60	m3_on	0	0	No	No	No	No	6	6
93	1x34	1x37	m3_on	0	0	No	No	No	No	4	5
94	1x29	1x32	m3_on	0	0	No	No	No	No	4	7
95	7x48	7x51	m3_on	0	0	No	No	No	No	7	7
96	4x56	5x46	m3_on	0	0	No	No	No	No	8	8
97	1x51	1x55	m3_on	0	0	No	No	No	No	7	6
98	1x54	1x55	m3_on	0	0	No	No	No	No	6	6
99	2x64	2x65	m3_on	0	0	Yes	No	No	No	8	7
100	1x29	1x31	m3_on	0	0	No	No	No	No	4	7
101	1x44	1x48	m3_on	0	0	No	No	No	No	7	6
102	5x70	5x71	m3_on	0	0	No	No	No	No	8	7
103	4x68	4x69	m3_on	0	0	No	No	No	No	6	6
104	8x60	CT	m3_on	0	0	No	No	No	No	6	6
105	1x33	1x36	m3_on	0	0	No	No	No	No	6	8
106	6x35	6x39	m3_on	0	0	No	No	No	No	8	9
107	5x41	5x42	m3_on	0	0	No	No	No	No	8	7
108	8x52	8x56	m3_on	0	0	No	No	No	No	7	6
109	5x69	5x70	m3_on	0	0	No	No	No	No	7	8
110	4x44	4x48	m3_on	0	0	No	No	No	No	5	5
111	1x35	2x64	m3_on	0	0	No	No	Yes	No	8	8
112	5x63	5x64	m3_on	0	0	No	No	No	No	5	8
113	1x39	2x61	Shared	100	100	No	Yes	No	No	8	9
114	1x39	7x39	Shared	100	100	No	Yes	Yes	Yes	8	8
115	1x42	7x39	Shared	100	100	No	No	Yes	Yes	7	8
116	1x46	2x57	Shared	100	100	No	No	Yes	Yes	9	9
117	1x46	7x47	Shared	100	100	No	No	No	No	9	8
118	1x50	2x50	Shared	100	100	No	No	Yes	Yes	9	9
119	1x50	7x50	Shared	100	100	No	No	No	No	9	9
120	1x52	8x54	Shared	100	100	No	No	Yes	No	8	9
121	1x56	8x53	Shared	100	100	No	No	No	Yes	9	9
122	1x57	I1x51	Shared	100	100	Yes	No	No	No	9	8
123	1x57	2x41	Shared	100	100	Yes	No	No	No	9	8
124	1x57	2x44	Shared	100	100	Yes	No	No	No	9	8
125	1x60	I1x49	Shared	100	100	No	No	No	No	8	8
126	1x60	I1x50	Shared	100	100	No	No	Yes	Yes	8	9
127	1x60	8x53	Shared	100	100	No	No	No	Yes	8	9
128	I1x48	I1x51	Shared	100	100	No	No	No	No	8	8
129	8x49	I1x50	Shared	100	100	No	No	Yes	Yes	8	9
130	8x50	I1x50	Shared	100	100	Yes	Yes	Yes	Yes	9	9
131	2x37	2x40	Shared	100	100	No	No	Yes	No	8	9
132	2x38	I2x57	Shared	100	100	No	No	Yes	Yes	8	9
133	2x40	8x50	Shared	100	100	Yes	No	Yes	Yes	9	9
134	2x42	3x45	Shared	100	100	Yes	Yes	No	No	8	8
135	2x42	3x46	Shared	100	100	Yes	Yes	No	No	8	9
136	2x42	3x49	Shared	100	100	Yes	Yes	No	Yes	8	9
137	2x42	4x46	Shared	100	100	Yes	Yes	Yes	No	8	9
138	2x45	3x42	Shared	100	100	No	No	No	No	9	9
139	2x45	4x46	Shared	100	100	No	No	Yes	No	9	9
140	2x50	7x46	Shared	100	100	Yes	Yes	No	No	9	9
141	2x50	7x49	Shared	100	100	Yes	Yes	No	Yes	9	9
142	2x53	2x56	Shared	100	100	Yes	No	No	No	9	9
143	2x53	7x42	Shared	100	100	Yes	No	Yes	Yes	9	9
144	2x53	7x46	Shared	100	100	Yes	No	No	No	9	9
145	2x56	3x32	Shared	100	100	No	No	No	Yes	9	9
146	2x56	7x42	Shared	100	100	No	No	Yes	Yes	9	9
147	2x57	7x39	Shared	100	100	Yes	Yes	Yes	Yes	9	8
148	2x57	7x42	Shared	100	100	Yes	Yes	Yes	Yes	9	9
149	2x59	3x28	Shared	100	100	No	No	Yes	Yes	8	8
150	2x60	2x64	Shared	100	100	Yes	Yes	Yes	No	8	8
151	2x60	3x28	Shared	100	100	Yes	Yes	Yes	Yes	8	8
152	2x60	7x38	Shared	100	100	Yes	Yes	No	Yes	8	7
153	2x60	7x39	Shared	100	100	Yes	Yes	Yes	Yes	8	8
154	2x64	7x35	Shared	100	100	Yes	No	No	No	8	6
155	2x66	E1x49	Shared	100	33.3333	No	No	No	No	7	5
156	E1x50	E1x52	Shared	100	100	Yes	Yes	No	No	9	8
157	3x25	E1x50	Shared	100	100	No	No	Yes	Yes	9	9
158	3x28	E1x50	Shared	100	100	Yes	Yes	Yes	Yes	8	9
159	3x22	E2	Shared	100	100	No	No	Yes	Yes	5	6
160	3x25	E2x50	Shared	100	100	No	No	No	No	9	9
161	3x26	4x65	Shared	100	100	Yes	No	No	No	8	7
162	3x28	3x29	Shared	100	100	Yes	Yes	No	Yes	8	8
163	3x29	4x61	Shared	100	100	No	Yes	No	No	8	8
164	3x29	E2x52	Shared	100	100	No	Yes	Yes	Yes	8	8
165	3x32	7x42	Shared	100	100	No	Yes	Yes	Yes	9	9
166	3x32	Lig	Shared	100	100	No	Yes	Yes	Yes	9	0
167	3x33	4x57	Shared	100	100	No	Yes	Yes	Yes	9	9
168	3x33	E2x52	Shared	100	100	No	Yes	Yes	Yes	9	8
169	3x33	Lig	Shared	100	100	No	Yes	Yes	Yes	9	0
170	3x36	Lig	Shared	100	100	No	No	Yes	Yes	9	0
171	3x37	4x53	Shared	100	100	Yes	Yes	No	No	9	9
172	3x37	4x57	Shared	100	100	Yes	Yes	Yes	Yes	9	9
173	3x37	Lig	Shared	100	100	Yes	Yes	Yes	Yes	9	0
174	3x38	4x50	Shared	100	100	No	No	No	Yes	9	9
175	3x40	6x44	Shared	100	100	No	No	Yes	Yes	9	9
176	3x44	5x50	Shared	100	100	No	No	No	No	8	9
177	3x45	4x45	Shared	100	0	No	No	No	No	8	8
178	3x48	5x57	Shared	100	100	No	No	No	No	8	8
179	3x49	I2x53	Shared	100	100	No	Yes	No	Yes	9	9
180	3x49	I2x57	Shared	100	100	No	Yes	Yes	Yes	9	9
181	3x51	3x52	Shared	100	100	Yes	Yes	No	No	9	7
182	3x51	3x55	Shared	100	100	Yes	Yes	No	No	9	8
183	3x51	5x60	Shared	100	100	Yes	Yes	No	No	9	8
184	3x52	I2x53	Shared	100	100	No	No	No	Yes	7	9
185	3x53	I2x54	Shared	100	33.3333	No	Yes	No	No	9	8
186	3x54	5x64	Shared	100	0	No	No	No	No	8	8
187	I2x53	I2x57	Shared	100	100	No	Yes	Yes	Yes	9	9
188	4x38	4x40	Shared	100	0	No	No	No	No	9	5
189	4x38	4x41	Shared	100	100	No	No	No	No	9	8
190	4x61	E2x52	Shared	100	100	No	No	Yes	Yes	8	8
191	4x64	E2	Shared	100	100	No	No	Yes	Yes	6	6
192	4x65	E2	Shared	100	100	No	No	Yes	Yes	7	6
193	E2	E2	Shared	100	100	Yes	Yes	Yes	Yes	6	6
194	E2	E2x51	Shared	100	100	Yes	Yes	No	No	6	4
195	E2	E2x52	Shared	100	100	Yes	Yes	Yes	Yes	6	8
196	5x39	E2	Shared	100	66.6667	No	No	Yes	Yes	8	6
197	5x36	5x38	Shared	100	100	Yes	No	No	No	8	5
198	5x36	5x39	Shared	100	100	Yes	No	No	No	8	8
199	5x41	6x56	Shared	100	100	No	No	No	No	8	7
200	5x47	5x48	Shared	100	100	Yes	Yes	Yes	No	9	8
201	5x47	5x51	Shared	100	100	Yes	Yes	No	No	9	8
202	5x47	6x44	Shared	100	100	Yes	Yes	Yes	Yes	9	9
203	5x47	6x48	Shared	100	100	Yes	Yes	Yes	Yes	9	9
204	5x47	6x52	Shared	100	100	Yes	Yes	No	No	9	9
205	5x48	6x56	Shared	100	0	Yes	No	No	No	8	7
206	6x40	7x52	Shared	100	33.3333	Yes	No	No	No	9	9
207	6x40	7x53	Shared	100	100	Yes	No	Yes	Yes	9	9
208	6x44	6x48	Shared	100	100	Yes	Yes	Yes	Yes	9	9
209	6x44	7x45	Shared	100	100	Yes	Yes	Yes	Yes	9	9
210	6x47	6x48	Shared	100	100	No	Yes	Yes	Yes	9	9
211	6x47	7x45	Shared	100	100	No	Yes	Yes	Yes	9	9
212	6x48	7x41	Shared	100	100	Yes	Yes	No	No	9	9
213	6x48	7x45	Shared	100	100	Yes	Yes	Yes	Yes	9	9
214	6x48	Lig	Shared	100	100	Yes	Yes	Yes	Yes	9	0
215	6x51	Lig	Shared	100	100	No	No	Yes	Yes	9	0
216	6x52	Lig	Shared	100	100	No	No	Yes	Yes	9	0
217	6x58	7x34	Shared	100	100	No	No	No	Yes	7	6
218	6x59	6x60	Shared	100	100	Yes	No	No	No	8	7
219	6x61	E3	Shared	100	100	No	No	Yes	Yes	8	6
220	E3	E3	Shared	100	100	Yes	Yes	Yes	Yes	6	6
221	7x31	7x35	Shared	100	100	No	No	No	No	3	6
222	7x38	7x42	Shared	100	100	No	Yes	Yes	Yes	7	9
223	7x38	Lig	Shared	100	100	No	Yes	Yes	Yes	7	0
224	7x39	7x43	Shared	100	33.3333	Yes	Yes	No	No	8	7
225	7x41	Lig	Shared	100	100	No	No	Yes	Yes	9	0
226	7x45	7x49	Shared	100	100	Yes	Yes	No	Yes	9	9
227	8x47	8x49	Shared	100	100	No	No	No	No	9	8
228	8x47	8x50	Shared	100	100	No	No	Yes	Yes	9	9
229	8x48	8x51	Shared	100	100	No	No	No	No	7	9
230	8x48	8x52	Shared	100	0	No	No	No	No	7	7
231	8x50	8x54	Shared	100	100	Yes	Yes	Yes	No	9	9
232	E1x50	E2x50	Shared	100	100	Yes	Yes	No	No	9	9
233	4x57	Lig	Shared	100	100	Yes	Yes	Yes	Yes	9	0
234	5x41	6x59	Shared	100	100	No	No	Yes	No	8	8
235	7x30	7x33	Shared	100	100	No	No	No	No	7	6
236	7x51	7x55	Shared	100	100	No	No	No	No	7	8
237	1x34	1x38	Shared	100	100	No	No	No	No	4	5
238	2x41	4x39	Shared	33.3333	33.3333	No	No	No	No	8	8
239	3x37	3x41	Shared	66.6667	0	Yes	Yes	No	No	9	8
240	2x55	2x551	Shared	33.3333	100	No	No	No	Yes	6	6
241	3x40	5x50	Shared	0	100	No	No	No	No	9	9
242	2x50	3x39	Shared	33.3333	100	Yes	Yes	No	No	9	9
243	3x38	4x53	Shared	0	100	No	No	No	No	9	9
244	1x53	2x47	Shared	0	100	No	No	No	No	9	9
245	5x461	Lig	Shared	33.3333	100	No	No	Yes	Yes	9	0
246	4x48	4x52	Shared	33.3333	100	No	No	No	No	5	6
247	3x51	5x61	Shared	33.3333	100	Yes	Yes	No	No	9	9
248	3x47	5x54	Shared	0	100	No	No	No	No	9	9
249	2x49	4x50	Shared	33.3333	0	No	No	No	Yes	9	9
250	5x47	6x49	Shared	33.3333	100	Yes	Yes	Yes	No	9	8
251	3x56	I2x52	Shared	66.6667	100	No	No	No	No	8	7
252	2x551	3x31	Shared	33.3333	33.3333	No	Yes	No	No	6	6
253	E1x49	E2	Shared	33.3333	0	No	No	Yes	Yes	5	6
254	6x49	6x50	Shared	0	100	Yes	No	No	No	8	9
255	6x54	E3	Shared	33.3333	100	No	No	Yes	Yes	7	6
256	2x54	2x57	Shared	33.3333	100	No	No	Yes	Yes	8	9
257	1x28	1x31	Shared	33.3333	33.3333	No	No	No	No	0	7
258	5x49	5x50	Shared	0	100	No	No	No	No	7	9
259	4x60	E2	Shared	33.3333	66.6667	No	No	Yes	Yes	7	6
260	5x58	6x41	Shared	33.3333	33.3333	Yes	No	No	No	9	9
261	1x43	2x57	Shared	33.3333	66.6667	No	No	Yes	Yes	8	9
262	3x30	4x62	Shared	33.3333	100	No	No	Yes	No	7	7
263	3x34	4x54	Shared	33.3333	33.3333	No	No	No	No	9	5
264	1x47	2x55	Shared	0	100	No	No	No	No	8	6
265	6x49	6x53	Shared	0	0	Yes	No	No	No	8	8
266	4x41	I2x56	Shared	33.3333	100	No	No	No	No	8	7
267	4x62	4x63	Shared	0	100	Yes	No	No	No	7	7
268	1x54	2x44	Shared	33.3333	100	No	No	No	No	6	8
269	7x30	E3	Shared	0	100	No	No	Yes	Yes	7	6
270	6x36	7x56	Shared	0	100	Yes	No	No	No	9	9
271	7x32	7x33	Shared	33.3333	0	No	No	No	No	4	6
272	2x66	E1x51	Shared	0	0	No	No	No	No	7	7
273	5x56	5x60	Shared	0	100	No	No	No	No	7	8
274	1x49	7x50	Shared	0	100	No	No	No	No	9	9
275	E1	E1x49	Shared	33.3333	0	No	No	No	No	6	5
276	2x52	2x551	Shared	33.3333	33.3333	No	No	No	Yes	8	6
277	2x43	7x53	Shared	0	100	No	No	Yes	Yes	9	9
278	1x51	2x51	Shared	33.3333	100	No	No	No	No	7	8
279	4x58	4x59	Shared	0	66.6667	No	No	No	No	8	9
280	1x48	1x49	Shared	0	0	No	No	No	No	6	9
281	7x37	7x40	Shared	0	0	No	No	No	No	8	9
282	6x43	7x48	Shared	0	33.3333	No	No	No	No	8	7
283	8x51	8x55	Shared	33.3333	33.3333	No	No	No	No	9	7
284	1x36	2x65	Shared	0	0	No	No	No	No	8	7
285	1x45	7x47	Shared	0	33.3333	No	No	No	No	5	8
286	5x52	5x53	Shared	0	0	No	No	No	No	7	8
287	I2x51	I2x52	Shared	0	0	No	No	No	No	8	7
288	3x56	I2x50	Shared	0	0	No	No	No	No	8	9
289	4x54	4x58	Shared	33.3333	100	No	No	No	No	5	8
290	4x46	4x47	Shared	0	66.6667	Yes	No	No	No	9	5
291	1x54	2x48	Shared	0	0	No	No	No	No	6	7
292	4x51	4x55	Shared	0	0	No	No	No	No	5	6
293	1x32	2x65	Shared	0	0	No	No	No	No	7	7
294	1x38	1x42	Shared	0	0	No	No	No	No	5	7
295	3x27	4x62	Shared	0	0	No	No	Yes	No	6	7
296	4x64	4x67	Shared	0	100	No	No	No	No	6	6
297	1x39	1x40	m3_off	0	100	No	Yes	No	No	8	7
298	1x41	1x45	m3_off	0	100	No	No	No	No	4	5
299	1x50	2x47	m3_off	0	100	No	No	No	No	9	9
300	1x53	7x53	m3_off	0	100	No	No	Yes	Yes	9	9
301	1x55	8x57	m3_off	0	100	No	No	No	No	6	8
302	8x53	I1x50	m3_off	0	100	No	Yes	Yes	Yes	9	9
303	2x39	3x49	m3_off	0	100	No	No	No	Yes	9	9
304	2x39	3x50	m3_off	0	100	No	No	No	No	9	9
305	2x39	I2x57	m3_off	0	100	No	No	Yes	Yes	9	9
306	2x45	4x50	m3_off	0	100	No	No	No	Yes	9	9
307	2x46	3x39	m3_off	0	100	No	No	No	No	9	9
308	2x46	3x42	m3_off	0	100	No	No	No	No	9	9
309	2x59	E1x50	m3_off	0	100	No	No	Yes	Yes	8	9
310	2x60	7x35	m3_off	0	100	Yes	Yes	No	No	8	6
311	2x60	7x42	m3_off	0	100	Yes	Yes	Yes	Yes	8	9
312	2x61	7x39	m3_off	0	100	No	No	Yes	Yes	9	8
313	2x62	2x66	m3_off	0	100	No	No	No	No	7	7
314	2x63	7x31	m3_off	0	100	No	No	No	No	8	3
315	3x24	E1x50	m3_off	0	100	No	No	Yes	Yes	7	9
316	3x23	3x27	m3_off	0	100	No	No	No	No	5	6
317	3x28	3x32	m3_off	0	100	Yes	Yes	No	Yes	8	9
318	3x29	E2x50	m3_off	0	100	No	Yes	No	No	8	9
319	3x32	7x38	m3_off	0	100	No	Yes	No	Yes	9	7
320	3x33	7x38	m3_off	0	100	No	Yes	No	Yes	9	7
321	3x41	4x49	m3_off	0	100	No	No	No	No	8	9
322	3x41	4x52	m3_off	0	100	No	No	No	No	8	6
323	3x43	6x44	m3_off	0	100	No	No	Yes	Yes	9	9
324	3x48	3x52	m3_off	0	100	No	No	No	No	8	7
325	3x49	3x53	m3_off	0	100	No	Yes	No	Yes	9	9
326	3x53	I2x53	m3_off	0	100	No	Yes	No	Yes	9	9
327	3x53	I2x57	m3_off	0	100	No	Yes	Yes	Yes	9	9
328	3x54	6x30	m3_off	0	100	No	No	No	No	8	9
329	4x57	E2	m3_off	0	100	Yes	Yes	Yes	Yes	9	6
330	4x64	4x68	m3_off	0	100	No	No	No	No	6	6
331	4x65	4x66	m3_off	0	100	No	No	No	No	7	5
332	5x40	E2	m3_off	0	100	No	No	Yes	Yes	8	6
333	5x36	5x37	m3_off	0	100	Yes	No	No	No	8	6
334	5x40	6x55	m3_off	0	100	No	No	No	No	8	8
335	5x41	5x45	m3_off	0	100	No	No	No	No	8	7
336	5x42	5x45	m3_off	0	100	No	No	No	No	7	7
337	5x48	6x52	m3_off	0	100	Yes	No	No	No	8	9
338	5x51	6x45	m3_off	0	100	No	No	No	No	8	8
339	5x54	6x41	m3_off	0	100	No	No	No	No	9	9
340	5x58	5x59	m3_off	0	100	Yes	No	No	No	9	7
341	5x58	6x38	m3_off	0	100	Yes	No	No	No	9	9
342	5x59	5x62	m3_off	0	100	No	No	Yes	No	7	7
343	5x64	5x67	m3_off	0	100	No	No	No	No	8	7
344	5x65	6x31	m3_off	0	100	No	Yes	No	No	9	7
345	5x66	6x31	m3_off	0	100	No	No	No	No	7	7
346	6x27	6x31	m3_off	0	100	No	No	No	No	0	7
347	6x40	7x49	m3_off	0	100	Yes	No	No	Yes	9	9
348	6x47	7x40	m3_off	0	100	No	Yes	No	No	9	9
349	6x50	7x40	m3_off	0	100	No	No	No	No	9	9
350	6x51	7x34	m3_off	0	100	No	No	No	Yes	9	6
351	6x51	7x38	m3_off	0	100	No	No	No	Yes	9	7
352	6x54	7x34	m3_off	0	100	No	No	No	Yes	7	6
353	6x57	E3	m3_off	0	100	No	No	Yes	Yes	7	6
354	7x34	E3	m3_off	0	100	No	Yes	Yes	Yes	6	6
355	7x39	7x42	m3_off	0	100	Yes	Yes	Yes	Yes	8	9
356	7x49	7x53	m3_off	0	100	No	Yes	Yes	Yes	9	9
357	3x39	7x45	m3_off	0	100	No	No	Yes	Yes	9	9
358	1x52	8x58	m3_off	0	33.3333	No	No	No	No	8	9
359	2x40	2x43	m3_off	0	33.3333	Yes	No	No	No	9	9
360	5x43	Lig	m3_off	0	66.6667	No	No	Yes	Yes	9	0
361	6x39	7x52	m3_off	0	66.6667	No	No	No	No	9	9
362	5x54	6x44	m3_off	0	33.3333	No	No	Yes	Yes	9	9
363	4x52	4x56	m3_off	0	0	No	No	No	No	6	8
364	5x53	5x57	m3_off	0	0	No	No	No	No	8	8
365	5x65	6x30	m3_off	0	33.3333	No	Yes	No	No	9	9
366	2x42	4x42	m3_off	0	0	Yes	Yes	No	No	8	8
367	I1x48	I1x49	m3_off	0	66.6667	No	No	No	No	8	8
368	1x55	1x59	m3_off	0	33.3333	No	No	No	No	6	8
369	3x35	4x50	m3_off	0	0	No	No	No	Yes	8	9
370	3x30	4x61	m3_off	0	33.3333	No	No	No	No	7	8
371	1x47	1x51	m3_off	0	0	No	No	No	No	8	7
372	5x55	5x59	m3_off	0	0	No	No	No	No	7	7
373	5x63	5x67	m3_off	0	33.3333	No	No	No	No	5	7
374	2x551	2x59	m3_off	0	0	No	Yes	No	No	6	8
375	5x44	Lig	m3_off	0	0	No	No	Yes	Yes	9	0
376	1x52	8x57	m3_off	0	0	No	No	No	No	8	8
377	3x50	6x33	m3_off	0	0	No	No	No	No	9	9
378	6x37	6x41	m3_off	0	33.3333	No	No	No	No	9	9
379	5x65	6x34	m3_off	0	33.3333	No	Yes	No	No	9	9
380	1x43	2x58	m3_off	0	0	No	No	No	No	8	9
381	6x35	7x56	m3_off	0	33.3333	No	No	No	No	8	9
382	2x41	4x43	m3_off	0	0	No	No	No	No	8	5
383	7x54	8x54	m3_off	0	0	No	No	Yes	No	9	9
384	6x39	7x56	m3_off	0	0	No	No	No	No	9	9
385	7x48	7x52	m3_off	0	0	No	No	No	No	7	9
386	3x34	4x57	m3_off	0	0	No	No	Yes	Yes	9	9
387	1x28	1x30	m3_off	0	33.3333	No	No	No	No	0	4
388	8x52	8x53	m3_off	0	0	No	No	No	Yes	7	9
389	1x29	1x30	m3_off	0	33.3333	No	No	No	No	4	4
390	1x35	1x39	m3_off	0	0	No	No	No	Yes	8	8
391	5x61	5x65	m3_off	0	0	No	No	No	Yes	9	9
392	6x46	6x47	m3_off	0	0	No	No	No	Yes	6	9
393	4x40	4x44	m3_off	0	33.3333	No	No	No	No	5	5
394	7x32	7x36	m3_off	0	0	No	No	No	No	4	6
395	I2x50	I2x54	m3_off	0	0	No	No	No	No	9	8
396	6x42	6x46	m3_off	0	33.3333	No	No	No	No	6	6
397	6x32	8x47	m3_off	0	33.3333	No	No	No	No	9	9
398	1x33	1x37	m3_off	0	33.3333	No	No	No	No	6	5
399	1x31	1x34	m3_off	0	0	No	No	No	No	7	4
400	2x61	2x65	m3_off	0	0	No	No	No	No	9	7
401	4x69	E2	m3_off	0	0	No	No	Yes	Yes	6	6
402	8x59	8x60	m3_off	0	0	No	No	No	No	5	6
403	7x54	7x55	m3_off	0	0	No	No	No	No	9	8
404	1x29	1x33	m3_off	0	0	No	No	No	No	4	6
405	5x52	5x56	m3_off	0	0	No	No	No	No	7	7
406	4x39	4x40	m3_off	0	0	No	No	No	No	8	5
407	8x56	8x57	m3_off	0	0	No	No	No	No	6	8
408	3x21	E1x50	m3_off	0	0	No	No	Yes	Yes	9	9
409	4x54	4x55	m3_off	0	0	No	No	No	No	5	6

Orange: nodes, hubs and links specific of m3_on network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of m3_off network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	m3_on Avg Int. Strength	m3_off Avg Int. Strength	m3_on Num Of Links	m3_off Num Of Links	ConSurf
1	1x57	m3_on	33.3333	0	5	3	9
2	2x40	m3_on	100	33.3333	5	3	9
3	2x53	m3_on	0	0	4	3	9
4	2x64	m3_on	0	0	4	2	8
5	3x26	m3_on	33.3333	0	4	1	8
6	4x46	m3_on	0	0	4	3	9
7	4x62	m3_on	0	0	4	3	7
8	5x36	m3_on	33.3333	0	4	3	8
9	5x48	m3_on	33.3333	0	4	3	8
10	5x58	m3_on	33.3333	0	6	3	9
11	5x62	m3_on	0	0	4	1	7
12	6x36	m3_on	0	0	4	1	9
13	6x40	m3_on	0	0	4	3	9
14	6x49	m3_on	0	0	4	3	8
15	6x59	m3_on	66.6667	0	4	2	8
16	8x54	m3_on	33.3333	0	5	3	9
17	I1x50	Shared	100	100	4	4	9
18	2x42	Shared	100	100	5	5	8
19	2x50	Shared	33.3333	33.3333	4	4	9
20	2x57	Shared	0	66.6667	5	5	9
21	2x60	Shared	33.3333	100	4	6	8
22	E1x50	Shared	66.6667	100	5	7	9
23	3x28	Shared	66.6667	100	4	5	8
24	3x37	Shared	33.3333	0	4	4	9
25	3x51	Shared	100	100	5	4	9
26	I2x57	Shared	100	100	4	5	9
27	4x57	Shared	100	100	5	5	9
28	E2	Shared	100	100	12	13	6
29	E2x52	Shared	33.3333	100	4	4	8
30	5x47	Shared	100	100	6	6	9
31	6x44	Shared	100	66.6667	4	6	9
32	6x48	Shared	100	100	7	6	9
33	E3	Shared	100	100	6	7	6
34	7x39	Shared	100	100	5	7	8
35	7x42	Shared	100	100	6	7	9
36	7x45	Shared	66.6667	100	4	5	9
37	7x53	Shared	66.6667	66.6667	6	4	9
38	8x50	Shared	33.3333	66.6667	4	4	9
39	Lig	Shared	100	100	12	13	0
40	1x39	m3_off	0	0	2	4	8
41	2x551	m3_off	0	0	3	4	6
42	3x29	m3_off	0	33.3333	3	4	8
43	3x32	m3_off	33.3333	100	3	5	9
44	3x33	m3_off	33.3333	66.6667	3	4	9
45	3x49	m3_off	33.3333	100	3	5	9
46	3x53	m3_off	0	0	1	4	9
47	I2x53	m3_off	66.6667	66.6667	3	4	9
48	4x50	m3_off	33.3333	0	2	4	9
49	5x65	m3_off	0	0	1	4	9
50	6x47	m3_off	0	0	2	4	9
51	7x34	m3_off	0	100	2	4	6
52	7x38	m3_off	100	100	3	6	7
53	7x49	m3_off	66.6667	33.3333	3	4	9
54	8x53	m3_off	0	0	3	4	9

Orange: nodes, hubs and links specific of m3_on network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of m3_off network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	m3_on Recurrence	m3_off Recurrence	m3_on Hub1?	m3_off Hub1?	m3_on Hub2?	m3_off Hub2?	ConSurf1	ConSurf2
1	2x57	7x39	m3_on	17.9058	2.38049	Yes	Yes	Yes	Yes	9	8
2	1x50	2x51	m3_on	57.4404	0	No	No	No	No	9	8
3	1x51	2x51	m3_on	56.0384	2.08212	No	No	No	No	7	8
4	1x51	1x55	m3_on	54.7528	0	No	No	No	No	7	6
5	1x54	1x55	m3_on	53.7056	0	No	No	No	No	6	6
6	1x54	2x44	m3_on	51.6579	4.2745	No	No	No	No	6	8
7	1x57	2x44	m3_on	51.0239	6.37608	Yes	No	No	No	9	8
8	1x57	2x40	m3_on	47.1262	0	Yes	No	Yes	No	9	9
9	2x40	I1x50	m3_on	32.3328	0	Yes	No	Yes	Yes	9	9
10	1x60	8x53	m3_on	23.5835	0.616203	No	No	No	Yes	8	9
11	2x46	7x49	m3_on	85.1774	0	No	No	No	Yes	9	9
12	2x46	3x43	m3_on	84.5375	0	No	No	No	No	9	9
13	3x43	7x53	m3_on	83.9209	0	No	No	Yes	Yes	9	9
14	3x46	7x53	m3_on	34.8807	0	No	No	Yes	Yes	9	9
15	2x42	3x46	m3_on	40.1338	2.41941	Yes	Yes	No	No	8	9
16	3x49	I2x57	m3_on	21.5474	4.64422	No	Yes	Yes	Yes	9	9
17	7x42	Lig	m3_on	34.9331	0	Yes	Yes	Yes	Yes	9	0
18	2x39	2x40	m3_on	20.5468	0	No	No	Yes	No	9	9
19	I2x54	I2x57	m3_on	23.9267	0	No	No	Yes	Yes	8	9
20	2x60	2x64	m3_on	34.014	2.59454	Yes	Yes	Yes	No	8	8
21	2x64	7x35	m3_on	20.1803	0.00648635	Yes	No	No	No	8	6
22	3x26	E2	m3_on	13.502	0	Yes	No	Yes	Yes	8	6
23	3x40	5x50	m3_on	12.0942	6.25932	No	No	No	No	9	9
24	5x58	7x53	m3_on	52.7865	0	Yes	No	Yes	Yes	9	9
25	3x47	5x58	m3_on	30.2967	0	No	No	Yes	No	9	9
26	3x47	5x57	m3_on	28.0279	0	No	No	No	No	9	8
27	3x51	5x57	m3_on	25.9104	0	Yes	Yes	No	No	9	8
28	3x51	3x55	m3_on	22.6876	2.76318	Yes	Yes	No	No	9	8
29	3x55	3x56	m3_on	14.2583	0	No	No	No	No	8	8
30	3x56	I2x52	m3_on	10.7097	5.51988	No	No	No	No	8	7
31	5x41	6x59	m3_on	15.2065	6.14257	No	No	Yes	No	8	8
32	5x47	6x52	m3_on	13.7115	7.53713	Yes	Yes	No	No	9	9
33	5x58	6x37	m3_on	29.203	0	Yes	No	No	No	9	9
34	6x40	7x53	m3_on	10.7097	2.2313	Yes	No	Yes	Yes	9	9
35	5x62	6x37	m3_on	27.1611	0	Yes	No	No	No	7	9
36	5x62	5x66	m3_on	18.9238	0	Yes	No	No	No	7	7
37	5x66	5x69	m3_on	12.9087	0	No	No	No	No	7	7
38	7x34	7x35	m3_on	17.2542	0	No	Yes	No	No	6	6
39	6x58	7x34	m3_on	15.7301	1.83564	No	No	No	Yes	7	6
40	6x58	E3	m3_on	14.3397	0	No	No	Yes	Yes	7	6
41	8x53	8x57	m3_on	22.3269	0	No	Yes	No	No	9	8
42	8x57	8x58	m3_on	18.3711	0	No	No	No	No	8	9
43	8x55	8x58	m3_on	16.3758	0	No	No	No	No	7	9
44	8x51	8x55	m3_on	12.3502	2.14049	No	No	No	No	9	7
45	8x48	8x51	m3_on	10.32	4.2745	No	No	No	No	7	9
46	2x64	2x65	m3_on	12.3095	0	Yes	No	No	No	8	7
47	3x34	4x53	m3_on	12.6643	0	No	No	No	No	9	9
48	2x39	I2x54	m3_on	21.1809	0	No	No	No	No	9	8
49	1x38	1x42	Shared	11.4194	36.3689	No	No	No	No	5	7
50	1x42	7x39	Shared	14.1187	40.4748	No	No	Yes	Yes	7	8
51	2x57	7x42	Shared	28.3479	25.5757	Yes	Yes	Yes	Yes	9	9
52	2x53	7x42	Shared	44.8749	26.127	Yes	No	Yes	Yes	9	9
53	2x53	7x46	Shared	44.968	27.1	Yes	No	No	No	9	9
54	2x50	7x46	Shared	45.0785	26.2892	Yes	Yes	No	No	9	9
55	1x50	2x50	Shared	64.5084	14.7759	No	No	Yes	Yes	9	9
56	2x40	8x50	Shared	22.2339	71.1293	Yes	No	Yes	Yes	9	9
57	8x50	8x54	Shared	19.3717	20.8147	Yes	Yes	Yes	No	9	9
58	1x60	I1x50	Shared	27.1321	31.3291	No	No	Yes	Yes	8	9
59	2x50	7x49	Shared	45.8115	34.0144	Yes	Yes	No	Yes	9	9
60	2x42	3x49	Shared	26.975	84.5495	Yes	Yes	No	Yes	8	9
61	6x48	Lig	Shared	80.4654	66.2969	Yes	Yes	Yes	Yes	9	0
62	6x48	7x45	Shared	81.2507	47.0065	Yes	Yes	Yes	Yes	9	9
63	7x45	7x49	Shared	100	66.8548	Yes	Yes	No	Yes	9	9
64	2x60	7x39	Shared	12.8272	28.4426	Yes	Yes	Yes	Yes	8	8
65	2x60	7x38	Shared	48.5631	30.7193	Yes	Yes	No	Yes	8	7
66	7x38	Lig	Shared	36.8063	44.8401	No	Yes	Yes	Yes	7	0
67	2x42	4x46	Shared	11.6172	95.5244	Yes	Yes	Yes	No	8	9
68	2x60	3x28	Shared	19.1972	11.2862	Yes	Yes	Yes	Yes	8	8
69	3x28	E1x50	Shared	11.2042	11.2084	Yes	Yes	Yes	Yes	8	9
70	E2	E2x52	Shared	41.7452	17.0072	Yes	Yes	Yes	Yes	6	8
71	3x33	Lig	Shared	39.7789	11.1825	No	Yes	Yes	Yes	9	0
72	3x37	Lig	Shared	22.7516	50.4249	Yes	Yes	Yes	Yes	9	0
73	3x37	4x53	Shared	20.8784	57.229	Yes	Yes	No	No	9	9
74	5x47	6x48	Shared	25.8406	16.1964	Yes	Yes	Yes	Yes	9	9
75	5x47	5x48	Shared	32.8738	11.4679	Yes	Yes	Yes	No	9	8
76	5x48	6x56	Shared	23.9907	18.1358	Yes	No	No	No	8	7
77	5x41	6x56	Shared	21.21	15.2689	No	No	No	No	8	7
78	6x52	Lig	Shared	13.63	17.9412	No	No	Yes	Yes	9	0
79	5x47	6x49	Shared	12.1873	10.1122	Yes	Yes	Yes	No	9	8
80	3x34	4x54	Shared	10.5817	12.3176	No	No	No	No	9	5
81	7x38	7x42	Shared	12.9145	36.1095	No	Yes	Yes	Yes	7	9
82	3x33	E2x52	Shared	40.6923	22.1184	No	Yes	Yes	Yes	9	8
83	6x44	7x45	Shared	18.2606	21.0612	Yes	Yes	Yes	Yes	9	9
84	5x47	6x44	Shared	13.8685	10.5209	Yes	Yes	Yes	Yes	9	9
85	3x32	Lig	m3_off	1.72193	44.9893	No	Yes	Yes	Yes	9	0
86	6x51	Lig	m3_off	3.54276	15.3791	No	No	Yes	Yes	9	0
87	1x34	1x38	m3_off	8.58057	31.8674	No	No	No	No	4	5
88	7x39	7x42	m3_off	0	48.706	Yes	Yes	Yes	Yes	8	9
89	3x32	7x42	m3_off	0.645724	26.0492	No	Yes	Yes	Yes	9	9
90	1x39	7x39	m3_off	8.40605	12.0451	No	Yes	Yes	Yes	8	8
91	2x61	7x39	m3_off	0	16.1834	No	No	Yes	Yes	9	8
92	1x46	7x47	m3_off	4.10122	10.5792	No	No	No	No	9	8
93	1x46	2x57	m3_off	6.13729	14.0819	No	No	Yes	Yes	9	9
94	2x551	2x59	m3_off	0	14.3413	No	Yes	No	No	6	8
95	2x59	3x28	m3_off	3.31006	15.7878	No	No	Yes	Yes	8	8
96	3x28	3x32	m3_off	0	24.0514	Yes	Yes	No	Yes	8	9
97	1x52	8x54	m3_off	1.97208	12.6419	No	No	Yes	No	8	9
98	2x40	2x43	m3_off	0	74.4179	Yes	No	No	No	9	9
99	2x43	7x53	m3_off	1.83246	75.7865	No	No	Yes	Yes	9	9
100	7x49	7x53	m3_off	0	75.5659	No	Yes	Yes	Yes	9	9
101	1x57	I1x51	m3_off	4.11286	24.0643	Yes	No	No	No	9	8
102	I1x48	I1x51	m3_off	2.05934	26.0557	No	No	No	No	8	8
103	I1x48	I1x49	m3_off	0	28.034	No	No	No	No	8	8
104	1x60	I1x49	m3_off	2.25131	29.9994	No	No	No	No	8	8
105	8x50	I1x50	m3_off	0.447935	46.8055	Yes	Yes	Yes	Yes	9	9
106	8x53	I1x50	m3_off	0	12.0581	No	Yes	Yes	Yes	9	9
107	1x57	2x41	m3_off	3.7929	15.9564	Yes	No	No	No	9	8
108	2x45	4x46	m3_off	5.85806	100	No	No	Yes	No	9	9
109	2x45	4x50	m3_off	0	53.3048	No	No	No	Yes	9	9
110	3x38	4x50	m3_off	4.26411	54.1805	No	No	No	Yes	9	9
111	3x38	4x53	m3_off	6.38162	55.6399	No	No	No	No	9	9
112	3x39	7x45	m3_off	0	36.9008	No	No	Yes	Yes	9	9
113	2x46	3x39	m3_off	0	57.6831	No	No	No	No	9	9
114	2x46	3x42	m3_off	0	56.1588	No	No	No	No	9	9
115	E1x49	E2	m3_off	7.72542	14.03	No	No	Yes	Yes	5	6
116	4x57	E2	m3_off	0	47.4152	Yes	Yes	Yes	Yes	9	6
117	4x57	Lig	m3_off	6.6783	38.7948	Yes	Yes	Yes	Yes	9	0
118	3x28	3x29	m3_off	6.87609	11.6106	Yes	Yes	No	Yes	8	8
119	3x30	4x62	m3_off	1.94881	11.6819	No	No	Yes	No	7	7
120	3x30	4x61	m3_off	0	14.5229	No	No	No	No	7	8
121	3x33	7x38	m3_off	0	18.3758	No	Yes	No	Yes	9	7
122	6x44	6x48	m3_off	0.715532	16.5661	Yes	Yes	Yes	Yes	9	9
123	3x37	3x41	m3_off	2.13496	10.923	Yes	Yes	No	No	9	8
124	5x54	6x44	m3_off	0	18.1034	No	No	Yes	Yes	9	9
125	3x49	I2x53	m3_off	4.29901	56.3599	No	Yes	No	Yes	9	9
126	3x52	I2x53	m3_off	9.02269	55.4323	No	No	No	Yes	7	9
127	3x48	3x52	m3_off	0	10.8517	No	No	No	No	8	7
128	3x49	3x53	m3_off	0	15.3662	No	Yes	No	Yes	9	9
129	3x51	3x52	m3_off	8.91216	42.6088	Yes	Yes	No	No	9	7
130	3x51	5x61	m3_off	1.8441	29.7464	Yes	Yes	No	No	9	9
131	5x61	5x65	m3_off	0	27.1064	No	No	No	Yes	9	9
132	5x65	6x30	m3_off	0	13.7121	No	Yes	No	No	9	9
133	3x54	6x30	m3_off	0	10.9944	No	No	No	No	8	9
134	3x53	I2x54	m3_off	1.92554	13.7121	No	Yes	No	No	9	8
135	I2x50	I2x54	m3_off	0	10.9944	No	No	No	No	9	8
136	2x41	4x39	m3_off	1.75102	12.0841	No	No	No	No	8	8
137	4x39	4x40	m3_off	0	10.3068	No	No	No	No	8	5
138	3x34	4x57	m3_off	0	14.7435	No	No	Yes	Yes	9	9
139	5x39	E2	m3_off	1.76847	11.1371	No	No	Yes	Yes	8	6
140	5x54	6x41	m3_off	0	14.4321	No	No	No	No	9	9
141	5x58	6x41	m3_off	4.20593	10.3717	Yes	No	No	No	9	9
142	6x40	7x49	m3_off	0	14.2635	Yes	No	No	Yes	9	9
143	6x40	7x52	m3_off	1.78592	14.5229	Yes	No	No	No	9	9
144	6x51	7x34	m3_off	0	20.3477	No	No	No	Yes	9	6
145	7x34	E3	m3_off	0	14.5294	No	Yes	Yes	Yes	6	6
146	1x28	1x31	m3_off	1.47179	22.8255	No	No	No	No	0	7
147	1x31	1x34	m3_off	0	27.3529	No	No	No	No	7	4
148	2x61	2x65	m3_off	0	12.136	No	No	No	No	9	7
149	1x28	1x30	m3_off	0	18.285	No	No	No	No	0	4
150	1x29	1x30	m3_off	0	13.7316	No	No	No	No	4	4
151	2x50	3x39	m3_off	1.96626	31.848	Yes	Yes	No	No	9	9
152	4x61	E2x52	m3_off	1.58813	13.5046	No	No	Yes	Yes	8	8
153	3x33	4x57	m3_off	2.61198	13.2257	No	Yes	Yes	Yes	9	9
154	3x37	4x57	m3_off	2.15823	16.138	Yes	Yes	Yes	Yes	9	9
155	2x45	3x42	m3_off	3.91507	54.8875	No	No	No	No	9	9

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
3x32	Lig	Shared	3.79333	11.03	1	1	1	0
3x33	Lig	Shared	17.8167	6.32333	1	1	1	0
3x36	Lig	Shared	8.01667	7.03333	0	0	1	0
3x37	Lig	Shared	3.81333	4.83667	1	1	1	0
4x57	Lig	Shared	4.11333	15.8067	1	1	1	0
5x461	Lig	Shared	5.03	3.35	0	0	1	0
6x48	Lig	Shared	13.66	8.67667	1	1	1	0
6x51	Lig	Shared	10.7933	15.6267	1	1	1	0
6x52	Lig	Shared	9.41	5.18667	1	1	1	0
7x38	Lig	Shared	16.5933	13.5867	1	1	1	0
7x41	Lig	Shared	6.44667	6.48333	1	1	1	0
2x53	2x56	Shared	4.12667	6.19333	1	1	2	2
2x53	7x42	Shared	4.83667	5.64333	1	1	2	1
2x56	3x32	Shared	11.29	9.32333	1	1	2	1
2x56	7x42	Shared	6.78333	4.66333	1	1	2	1
2x57	7x39	Shared	7.75667	3.87667	1	0	2	2
2x57	7x42	Shared	4.39	5.98333	1	0	2	1
2x60	3x28	Shared	7.01667	4.01	1	0	2	2
2x60	7x38	Shared	17.5367	8.94333	1	0	2	1
2x60	7x39	Shared	4.34333	4.00667	1	0	2	2
2x60	7x42	m3_off	6.53333	0	1	0	2	1
3x28	3x32	m3_off	4.84	0	1	0	2	1
3x32	7x38	m3_off	6.51667	0	1	1	1	1
3x32	7x42	Shared	11.1067	10.7267	1	1	1	1
3x33	4x57	Shared	12.22	15.0233	1	1	1	1
3x33	E2x52	Shared	9.67	3.91333	1	1	1	2
3x33	7x38	m3_off	3.64	0	1	1	1	1
3x37	4x53	Shared	8.94	7.45	1	1	1	2
3x37	4x57	Shared	7.91	7.53333	1	1	1	1
3x40	6x44	Shared	3.49333	7.43	0	1	2	2
4x57	E2	m3_off	5.57667	0	1	1	1	2
E2	E2	Shared	56.5067	35.3467	1	1	2	2
E2	E2x52	Shared	16.48	14.33	1	1	2	2
5x47	5x48	Shared	7.56667	7.56667	1	1	2	2
5x47	6x44	Shared	4.64333	5.71667	1	1	2	2
5x47	6x48	Shared	6.01333	7.01667	1	1	2	1
5x47	6x52	Shared	27.3867	16.5133	1	1	2	1
5x48	6x52	m3_off	4.65	0	1	0	2	1
6x44	6x48	Shared	17.7033	8.02	1	1	2	1
6x44	7x45	Shared	4.83	5.23333	1	1	2	2
6x47	6x48	Shared	4.85	5.65667	1	1	2	1
6x47	7x45	Shared	8.28667	5.85	1	1	2	2
6x48	7x41	Shared	13.0633	11.7533	1	1	1	1
6x48	7x45	Shared	6.02667	6.78	1	1	1	2
6x51	7x34	m3_off	8.03667	0	1	1	1	2
6x51	7x38	m3_off	8.60667	0	1	1	1	1
7x38	7x42	Shared	8.93667	7.28	1	1	1	1
7x39	7x42	m3_off	7.71667	0	1	0	2	1
5x43	Lig	m3_off	3.11	0	0	0	1	0
3x37	3x41	Shared	2.8	3.74	1	1	1	2
5x44	Lig	m3_off	2.35667	0	0	0	1	0
3x34	4x57	m3_off	1.63667	0	0	0	2	1
3x40	6x48	m3_on	0	4.9	0	1	2	1
4x56	4x57	m3_on	0	5.31333	0	0	2	1
4x57	5x43	m3_on	0	10.1067	1	1	1	1
6x51	6x52	m3_on	0	5.04	1	1	1	1
6x51	6x55	m3_on	0	6.31	1	1	1	2
7x42	Lig	m3_on	0	5.22667	1	1	1	0
5x44	5x48	m3_on	0	2.22333	0	0	1	2
3x34	4x53	m3_on	0	1.61667	0	0	2	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	m3_off	4U15-M₃-Tiotropium 4U16-M₃-N-Methyl-Scopolamine 5ZHP-M₃-PubChem 134828589
	m3_on	8E9Z-M₃-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M₃-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M₃-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2

Network Difference
Value	m3_on	m3_off
I_min	3.75	3.29333
Number of Linked Nodes	264	257
Number of Specific Nodes	9 (3.41%)	2 (0.78%)
Number of Shared Nodes	255 (96.59%)	255 (99.22%)
Number of Links	296	297
Number of Specific Links	112 (37.84%)	113 (38.05%)
Number of Shared Links	184 (62.16%)	184 (61.95%)
Number of Hubs	39	38
Number of Specific Hubs	16 (41.03%)	15 (39.47%)
Number of Shared Hubs	23 (58.97%)	23 (60.53%)
Average % Shared Neighbours (Jaccard)	46.10
Average % Shared Neighbours (Otsuka)	55.43
Average % Shared Neighbours (Overlap Coefficient)	65.86
Average % Shared Cliques (k3-6)	56.71
Graphlets Similarity	0.639778

Paths Difference
Value	m3_on	m3_off
Number Of Nodes in MetaPath	80	96
Specific Nodes in MetaPath	30 (37.50%)	46 (47.92%)
Shared Nodes in MetaPath	255 (96.59%)	255 (96.59%)
Number Of Links MetaPath	84	107
Specific Links in MetaPath	48 (57.14%)	71 (66.36%)
Shared Links in MetaPath	184 (62.16%)	184 (62.16%)
Number of Shortest Paths	45822	52018
Length Of Smallest Path	3	3
Average Path Length	13.3567	12.4032
Length of Longest Path	34	35
Minimum Path Strength	0.7	0.506667
Average Path Strength	6.13667	6.42766
Maximum Path Strength	15.7167	20.1283
Minimum Path Correlation	0.7	0.7
Average Path Correlation	0.924269	0.914551
Maximum Path Correlation	0.99	0.99
Minimum % Of Corr. Nodes	4.34783	4
Average % Of Corr. Nodes	48.476	47.0683
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	43.964	47.7882
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download m3_off_on.zip<

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