psnGPCR

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Orange: nodes, hubs and links specific of m4_on network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of m4_off network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	m4_on Int. Strength	m4_off Int. Strength	m4_on Hub1?	m4_off Hub1?	m4_on Hub2?	m4_off Hub2?	ConSurf1	ConSurf2
1	I1x48	I1x51	m4_on	7.885	0	No	No	No	No	8	8
2	2x39	3x49	m4_on	6.7325	0	No	No	Yes	No	9	9
3	2x46	3x43	m4_on	5.1925	0	Yes	Yes	No	No	9	9
4	2x60	2x63	m4_on	6.7	0	Yes	Yes	No	No	8	8
5	3x28	3x29	m4_on	3.7	0	Yes	Yes	No	No	7	8
6	3x32	Lig	m4_on	4.735	0	Yes	Yes	Yes	Yes	9	0
7	3x33	6x51	m4_on	6.4525	0	Yes	Yes	Yes	Yes	9	9
8	3x37	3x41	m4_on	5.6075	0	Yes	No	No	No	9	8
9	3x37	Lig	m4_on	3.9625	0	Yes	No	Yes	Yes	9	0
10	3x40	6x44	m4_on	4.5875	0	No	No	Yes	Yes	9	9
11	3x40	6x48	m4_on	4.29	0	No	No	Yes	Yes	9	9
12	3x43	7x53	m4_on	6.74	0	No	No	Yes	No	9	9
13	3x44	3x48	m4_on	5.175	0	No	No	No	No	8	7
14	3x46	3x50	m4_on	6.2625	0	No	No	No	Yes	9	9
15	3x46	7x53	m4_on	4.835	0	No	No	Yes	No	9	9
16	3x47	5x57	m4_on	5.2575	0	No	No	No	No	9	8
17	3x47	5x58	m4_on	8.2675	0	No	No	Yes	No	9	9
18	3x50	5x58	m4_on	5.4	0	No	Yes	Yes	No	9	9
19	3x50	7x53	m4_on	7.2	0	No	Yes	Yes	No	9	9
20	4x56	4x57	m4_on	5.9775	0	No	No	Yes	Yes	8	8
21	4x57	5x43	m4_on	8.185	0	Yes	Yes	No	No	8	9
22	4x64	5x39	m4_on	4.2925	0	Yes	Yes	No	No	7	8
23	4x65	4x66	m4_on	11.7125	0	No	No	No	No	7	6
24	4x65	E2.Q188	m4_on	5.12	0	No	No	Yes	Yes	7	8
25	E2.Q188	E2.V180	m4_on	4.6575	0	Yes	Yes	No	No	8	5
26	E2.F189	E2x52	m4_on	6.28	0	Yes	No	Yes	Yes	8	7
27	5x39	E2.F189	m4_on	7.21	0	No	No	Yes	No	8	8
28	5x40	E2.L190	m4_on	4.055	0	No	No	No	No	8	5
29	5x37	6x59	m4_on	5.2475	0	No	No	No	No	5	7
30	5x45	5x48	m4_on	4.5325	0	No	No	Yes	No	7	8
31	5x47	6x49	m4_on	6.1625	0	Yes	Yes	No	No	9	7
32	5x48	6x56	m4_on	6.74	0	Yes	No	No	No	8	7
33	5x51	6x44	m4_on	4.2575	0	No	No	Yes	Yes	8	9
34	5x58	5x61	m4_on	3.63	0	Yes	No	No	No	9	9
35	5x58	6x37	m4_on	9.065	0	Yes	No	No	No	9	9
36	5x58	6x40	m4_on	3.9275	0	Yes	No	Yes	No	9	9
37	5x62	6x34	m4_on	5.1975	0	No	No	No	No	8	9
38	5x65	6x33	m4_on	5.2525	0	No	No	No	No	9	9
39	5x66	6x30	m4_on	11.92	0	No	No	Yes	Yes	7	9
40	6x48	6x52	m4_on	3.6725	0	Yes	Yes	No	No	9	9
41	6x51	6x52	m4_on	5.2325	0	Yes	Yes	No	No	9	9
42	6x51	7x41	m4_on	4.03	0	Yes	Yes	No	No	9	9
43	7x54	8x50	m4_on	4.855	0	No	No	Yes	Yes	9	9
44	7x55	8x54	m4_on	5.4825	0	No	No	Yes	Yes	8	9
45	8x52	8x55	m4_on	4.6425	0	No	No	No	No	6	6
46	E2x51	Lig	m4_on	7.925	0	No	No	Yes	Yes	4	0
47	7x34	Lig	m4_on	4.875	0	No	Yes	Yes	Yes	6	0
48	4x41	4x44	m4_on	3.5325	0	No	No	No	No	8	3
49	5x66	5x68	m4_on	3.465	0	No	No	No	No	7	8
50	7x30	E3.I430	m4_on	3.39	0	No	No	Yes	No	6	6
51	6x40	7x52	m4_on	3.2725	0	Yes	No	No	No	9	9
52	1x54	2x48	m4_on	3.24	0	Yes	No	No	No	8	8
53	3x44	5x53	m4_on	3.2075	0	No	No	No	No	8	8
54	2x64	7x35	m4_on	3.095	0	No	No	No	No	7	6
55	1x53	7x50	m4_on	3.0925	0	No	No	No	No	9	9
56	1x54	2x47	m4_on	2.8175	0	Yes	No	No	No	8	9
57	2x62	2x66	m4_on	2.6575	0	No	No	Yes	No	8	5
58	1x55	1x59	m4_on	2.6075	0	No	No	No	No	6	7
59	6x34	6x38	m4_on	2.5925	0	No	No	No	No	9	8
60	2x49	4x50	m4_on	2.59	0	No	No	No	No	9	9
61	5x55	6x41	m4_on	2.58	0	No	No	No	No	7	8
62	7x31	Lig	m4_on	2.5575	0	No	No	Yes	Yes	3	0
63	8x55	8x58	m4_on	2.43	0	No	No	No	No	6	0
64	6x31	6x35	m4_on	2.4	0	No	No	No	No	7	7
65	6x47	7x43	m4_on	2.38	0	No	No	No	No	9	6
66	6x32	6x36	m4_on	2.2525	0	No	No	No	No	9	9
67	8x54	8x55	m4_on	2.1375	0	Yes	Yes	No	No	9	6
68	7x55	8x51	m4_on	2.115	0	No	No	No	No	8	9
69	3x45	4x49	m4_on	2.0275	0	No	No	No	No	8	9
70	5x44	5x48	m4_on	2.0025	0	No	No	Yes	No	8	8
71	5x67	6x29	m4_on	1.9775	0	No	No	No	No	6	7
72	7x35	7x36	m4_on	1.9375	0	No	No	No	No	6	5
73	4x68	E2.K177	m4_on	1.8975	0	No	No	No	No	5	3
74	4x41	I2x57	m4_on	1.86	0	No	No	Yes	Yes	8	9
75	5x63	5x66	m4_on	1.82	0	No	No	No	No	4	7
76	5x65	6x30	m4_on	1.795	0	No	No	Yes	Yes	9	9
77	6x30	6x34	m4_on	1.7625	0	Yes	Yes	No	No	9	9
78	4x43	4x46	m4_on	1.76	0	No	No	No	No	5	9
79	3x27	4x62	m4_on	1.7275	0	No	No	No	No	7	6
80	8x53	8x56	m4_on	1.7125	0	Yes	No	No	Yes	9	6
81	1x49	1x52	m4_on	1.71	0	No	No	No	No	9	8
82	6x57	6x61	m4_on	1.7075	0	No	No	No	No	7	7
83	2x41	I1x51	m4_on	1.69	0	No	No	No	No	7	8
84	7x48	7x52	m4_on	1.6375	0	No	No	No	No	7	9
85	5x67	5x69	m4_on	1.615	0	No	No	No	No	6	6
86	1x47	1x48	m4_on	1.6	0	No	No	No	No	7	5
87	5x62	6x37	m4_on	1.55	0	No	No	No	No	8	9
88	1x32	2x66	m4_on	1.44	0	No	No	Yes	No	6	5
89	1x30	1x31	m4_on	1.425	0	No	No	Yes	No	0	0
90	6x28	6x31	m4_on	1.3825	0	No	No	No	No	6	7
91	3x21	3x24	m4_on	1.38	0	No	No	No	No	8	6
92	1x58	I1x51	m4_on	1.3575	0	No	No	No	No	5	8
93	7x30	7x32	m4_on	1.3125	0	No	No	No	No	6	4
94	4x63	4x67	m4_on	1.31	0	No	No	No	No	7	5
95	I2x52	I2x56	m4_on	1.2925	0	No	No	No	No	7	6
96	2x65	E1x51	m4_on	1.27	0	No	No	No	Yes	7	5
97	1x26	1x31	m4_on	1.2675	0	No	No	Yes	No	0	0
98	5x48	6x53	m4_on	1.26	0	Yes	No	No	No	8	7
99	4x56	5x46	m4_on	1.1825	0	No	No	No	No	8	7
100	5x41	5x42	m4_on	1.1325	0	No	No	No	No	7	7
101	8x53	8x57	m4_on	1.105	0	Yes	No	No	No	9	0
102	1x29	1x31	m4_on	1.0575	0	No	No	Yes	No	0	0
103	6x26	6x29	m4_on	0.93	0	No	No	No	No	0	7
104	6x29	6x32	m4_on	0.9275	0	No	No	No	No	7	9
105	4x68	4x69	m4_on	0.92	0	No	No	No	No	5	4
106	8x48	8x52	m4_on	0.8025	0	No	No	No	No	5	6
107	E3.S428	Lig	m4_on	0.7725	0	No	No	Yes	Yes	3	0
108	1x32	1x33	m4_on	0.76	0	No	No	No	No	6	6
109	1x29	1x32	m4_on	0.7525	0	No	No	No	No	0	6
110	1x41	1x42	m4_on	0.75	0	No	No	No	No	5	6
111	1x59	8x57	m4_on	0.745	0	No	No	No	No	7	0
112	2x66	2x67	m4_on	0.435	0	Yes	No	No	No	5	7
113	1x38	1x41	m4_on	0.405	0	No	No	No	No	5	5
114	3x23	3x24	m4_on	0.4	0	No	No	No	No	5	6
115	5x51	5x52	m4_on	0.4	0	No	No	No	No	8	5
116	7x51	7x55	m4_on	0.395	0	No	No	No	No	7	8
117	5x36	E2.S191	m4_on	0.3725	0	Yes	No	No	No	7	7
118	4x55	4x56	m4_on	0.3725	0	No	No	No	No	5	8
119	I2x55	I2x56	m4_on	0.345	0	No	No	No	No	6	6
120	8x56	8x59	m4_on	0.3225	0	No	Yes	No	No	6	0
121	1x27	1x31	m4_on	0.28	0	No	No	Yes	No	0	0
122	1x39	2x61	Shared	7.065	6.28	No	No	No	No	7	8
123	1x39	7x39	Shared	7.28	12.13	No	No	No	Yes	7	9
124	1x43	2x58	Shared	5.215	7.45	No	No	No	No	8	9
125	1x46	2x57	Shared	4.895	7.53	No	No	Yes	Yes	8	9
126	1x46	7x47	Shared	10.205	9.42	No	No	No	No	8	8
127	1x50	2x50	Shared	8.0775	6.73	No	No	Yes	Yes	9	9
128	1x50	7x50	Shared	6.1125	11.4	No	No	No	No	9	9
129	1x51	2x51	Shared	4.2825	4.28	No	No	No	No	7	9
130	1x52	8x54	Shared	7.9175	3.65	No	No	Yes	Yes	8	9
131	1x54	2x44	Shared	8.395	11.2	Yes	No	No	Yes	8	8
132	1x56	8x53	Shared	5.1975	6.4	No	No	Yes	No	9	9
133	1x57	2x40	Shared	5.6625	4.25	No	No	Yes	Yes	9	9
134	1x57	2x44	Shared	4.71	5.02	No	No	No	Yes	9	8
135	1x60	I1x49	Shared	3.63	7.92	No	No	No	No	8	6
136	1x60	I1x50	Shared	10.64	13.73	No	No	Yes	Yes	8	9
137	1x60	8x53	Shared	3.6575	8.77	No	No	Yes	No	8	9
138	2x40	I1x50	Shared	3.7775	4.12	Yes	Yes	Yes	Yes	9	9
139	8x49	I1x50	Shared	6.2625	5.9	No	No	Yes	Yes	8	9
140	8x50	I1x50	Shared	10.6575	12.18	Yes	Yes	Yes	Yes	9	9
141	2x37	2x40	Shared	5.8475	5.85	No	No	Yes	Yes	8	9
142	2x38	I2x57	Shared	10.7875	10.46	No	No	Yes	Yes	8	9
143	2x39	I2x57	Shared	8.4375	9.64	No	No	Yes	Yes	9	9
144	2x40	8x50	Shared	5.435	7.25	Yes	Yes	Yes	Yes	9	9
145	2x42	3x45	Shared	4.395	7.54	No	Yes	No	No	8	8
146	2x42	3x49	Shared	6.27	10.75	No	Yes	Yes	No	8	9
147	2x45	3x42	Shared	9.3125	8.94	No	No	No	No	9	9
148	2x45	4x46	Shared	6.9675	9.29	No	No	No	No	9	9
149	2x45	4x50	Shared	4.9425	6.18	No	No	No	No	9	9
150	2x46	2x50	Shared	6.445	5.43	Yes	Yes	Yes	Yes	9	9
151	2x46	3x42	Shared	4.4625	6.87	Yes	Yes	No	No	9	9
152	2x46	7x49	Shared	7.21	4.12	Yes	Yes	No	Yes	9	9
153	2x50	7x46	Shared	9.2025	10.31	Yes	Yes	No	No	9	9
154	2x50	7x49	Shared	9.09	6.73	Yes	Yes	No	Yes	9	9
155	2x52	3x35	Shared	6.5275	6.14	No	No	No	No	8	8
156	2x53	2x56	Shared	6.19	7.74	No	Yes	No	No	9	9
157	2x53	3x35	Shared	4.6075	3.07	No	Yes	No	No	9	8
158	2x53	7x46	Shared	8.515	9.29	No	Yes	No	No	9	9
159	2x54	2x57	Shared	4.365	5.24	No	No	Yes	Yes	9	9
160	2x56	3x32	Shared	9.94	10.31	No	No	Yes	Yes	9	9
161	2x56	7x42	Shared	6.9975	7.63	No	No	Yes	Yes	9	9
162	2x57	7x39	Shared	4.3625	8.14	Yes	Yes	No	Yes	9	9
163	2x57	7x42	Shared	7.78	4.79	Yes	Yes	Yes	Yes	9	9
164	2x59	3x28	Shared	10.535	10.25	No	No	Yes	Yes	7	7
165	2x60	2x64	Shared	3.93	7.25	Yes	Yes	No	No	8	7
166	2x60	3x28	Shared	5.305	6.75	Yes	Yes	Yes	Yes	8	7
167	2x60	7x38	Shared	17.6225	17.87	Yes	Yes	Yes	Yes	8	7
168	2x63	E1x50	Shared	7.96	10.61	No	No	Yes	Yes	8	9
169	2x63	E2.Q184	Shared	3.66	6.76	No	No	No	No	8	5
170	2x66	E1x49	Shared	5.6725	5.97	Yes	No	No	No	5	5
171	E1x50	E1x51	Shared	4.3875	5.4	Yes	Yes	No	Yes	9	5
172	E1x50	E1x52	Shared	11.3875	14.81	Yes	Yes	No	No	9	7
173	3x25	E1x50	Shared	6.8575	5.22	No	No	Yes	Yes	9	9
174	3x28	E1x50	Shared	6.795	9.37	Yes	Yes	Yes	Yes	7	9
175	E1x50	E2x50	Shared	10.775	10.45	Yes	Yes	No	Yes	9	9
176	3x24	E1x52	Shared	4.8425	5.96	No	No	No	No	6	7
177	3x22	E2.R178	Shared	4.495	6.91	No	No	Yes	Yes	4	5
178	3x25	E2x50	Shared	7.28	7.28	No	No	No	Yes	9	9
179	3x26	E2.R178	Shared	6.5525	9.53	No	No	Yes	Yes	8	5
180	3x29	E2x52	Shared	6.4225	5.71	No	No	Yes	Yes	8	7
181	3x32	7x42	Shared	10.915	6.9	Yes	Yes	Yes	Yes	9	9
182	3x33	4x57	Shared	13.8625	14.47	Yes	Yes	Yes	Yes	9	8
183	3x33	E2x52	Shared	5.6525	10.88	Yes	Yes	Yes	Yes	9	7
184	3x33	7x38	Shared	5.46	4.96	Yes	Yes	Yes	Yes	9	7
185	3x33	Lig	Shared	8.555	20.21	Yes	Yes	Yes	Yes	9	0
186	3x34	4x54	Shared	4.2575	3.93	No	No	No	No	8	7
187	3x36	Lig	Shared	6.8275	7.67	No	No	Yes	Yes	8	0
188	3x37	4x53	Shared	5.5875	8.94	Yes	No	No	No	9	9
189	3x37	4x57	Shared	8.475	10.17	Yes	No	Yes	Yes	9	8
190	3x38	4x50	Shared	8.105	9.08	No	No	No	No	9	9
191	3x48	5x57	Shared	7.9175	12.18	No	No	No	No	7	8
192	3x49	I2x53	Shared	7.4725	8.05	Yes	No	Yes	Yes	9	9
193	3x49	I2x57	Shared	10.72	13.1	Yes	No	Yes	Yes	9	9
194	3x51	3x52	Shared	4.9	5.16	Yes	Yes	No	No	9	7
195	3x51	3x55	Shared	14.355	12.48	Yes	Yes	No	No	9	9
196	3x51	5x57	Shared	10.55	4.69	Yes	Yes	No	No	9	8
197	3x51	5x60	Shared	4.355	3.27	Yes	Yes	No	No	9	7
198	3x52	I2x53	Shared	13.4125	13.41	No	No	Yes	Yes	7	9
199	3x53	I2x53	Shared	3.695	5.38	No	No	Yes	Yes	9	9
200	3x54	5x61	Shared	5.3775	6.14	No	No	No	No	9	9
201	I2x53	I2x54	Shared	4.5175	4.17	Yes	Yes	No	No	9	7
202	I2x53	I2x57	Shared	16.98	7.2	Yes	Yes	Yes	Yes	9	9
203	4x38	4x40	Shared	4.13	1.5	No	No	No	No	9	6
204	4x54	4x58	Shared	4.505	8.32	No	No	No	No	7	7
205	4x57	Lig	Shared	11.5975	8.73	Yes	Yes	Yes	Yes	8	0
206	4x64	4x68	Shared	8.58	7.36	Yes	Yes	No	No	7	5
207	4x64	E2.Q188	Shared	7.395	6.57	Yes	Yes	Yes	Yes	7	8
208	4x64	E2.F189	Shared	10.0225	6.01	Yes	Yes	Yes	No	7	8
209	4x65	E2.R178	Shared	6.7175	12.85	No	No	Yes	Yes	7	5
210	E2.R178	E2.V180	Shared	4.9025	10.46	Yes	Yes	No	No	5	5
211	E2.Q188	E2.T179	Shared	6.7325	17.01	Yes	Yes	No	No	8	5
212	E2.V180	E2x51	Shared	10.4875	11.8	No	No	No	No	5	4
213	E2.P181	E2.Q184	Shared	4.7375	7.9	No	No	No	No	3	5
214	E2.N183	E2.Q184	Shared	3.63	11.88	No	No	No	No	4	5
215	E2.L190	E2x52	Shared	7.135	9.99	No	No	Yes	Yes	5	7
216	5x36	5x37	Shared	5.2975	8.15	Yes	No	No	No	7	5
217	5x36	5x39	Shared	6.28	7.39	Yes	No	No	No	7	8
218	5x41	6x56	Shared	6.0875	8.53	No	No	No	No	7	7
219	5x47	5x48	Shared	9.03	8.25	Yes	Yes	Yes	No	9	8
220	5x47	5x51	Shared	6.8825	7.87	Yes	Yes	No	No	9	8
221	5x47	6x44	Shared	4.825	4.29	Yes	Yes	Yes	Yes	9	9
222	5x47	6x48	Shared	6.015	6.01	Yes	Yes	Yes	Yes	9	9
223	5x47	6x52	Shared	17.2175	24.17	Yes	Yes	No	No	9	9
224	5x49	5x50	Shared	3.6925	3.28	No	No	No	No	8	9
225	5x58	6x41	Shared	4.1025	2.34	Yes	No	No	No	9	8
226	6x40	7x53	Shared	7.2525	6.04	Yes	No	Yes	No	9	9
227	6x44	6x48	Shared	7.515	19.04	Yes	Yes	Yes	Yes	9	9
228	6x44	7x45	Shared	4.2275	4.83	Yes	Yes	Yes	Yes	9	9
229	6x45	6x49	Shared	5.32	3.04	No	No	No	No	8	7
230	6x47	7x45	Shared	9.87	7.31	No	No	Yes	Yes	9	9
231	6x48	7x41	Shared	8.1625	11.75	Yes	Yes	No	No	9	9
232	6x48	7x45	Shared	9.04	4.52	Yes	Yes	Yes	Yes	9	9
233	6x48	Lig	Shared	8.9375	13.09	Yes	Yes	Yes	Yes	9	0
234	6x51	6x55	Shared	6.625	3.79	Yes	Yes	No	No	9	8
235	6x51	7x38	Shared	6.455	8.94	Yes	Yes	Yes	Yes	9	7
236	6x51	Lig	Shared	11.1525	12.73	Yes	Yes	Yes	Yes	9	0
237	6x54	E3.I430	Shared	4.0075	7.29	No	Yes	Yes	No	7	6
238	6x58	E3.Q427	Shared	6.6025	6.6	No	No	No	No	5	3
239	6x58	7x34	Shared	4.8025	7.91	No	No	No	Yes	5	6
240	6x59	6x60	Shared	5.5125	5.19	No	No	No	No	7	6
241	6x61	E3.C429	Shared	7.28	7.28	No	No	No	No	7	7
242	7x34	E3.I430	Shared	8.515	17.62	No	Yes	Yes	No	6	6
243	7x30	7x33	Shared	6.1825	7.07	No	No	No	No	6	5
244	7x38	7x42	Shared	6.7	8.94	Yes	Yes	Yes	Yes	7	9
245	7x38	Lig	Shared	7.8575	17.97	Yes	Yes	Yes	Yes	7	0
246	7x41	Lig	Shared	4.8725	7.09	No	No	Yes	Yes	9	0
247	7x45	7x49	Shared	10.2175	12.26	Yes	Yes	No	Yes	9	9
248	8x47	8x49	Shared	5.85	4.39	No	No	No	No	9	8
249	8x47	8x50	Shared	8.4575	8.46	No	No	Yes	Yes	9	9
250	1x34	1x38	Shared	3.6025	6.55	No	No	No	No	4	5
251	2x66	E1x51	Shared	4.6	13.38	Yes	No	No	Yes	5	5
252	3x28	3x32	Shared	4.1875	13.4	Yes	Yes	Yes	Yes	7	9
253	3x30	4x62	Shared	3.5475	1.58	No	No	No	No	8	6
254	1x54	2x51	Shared	3.535	4.24	Yes	No	No	No	8	9
255	6x49	6x50	Shared	3.5	3.5	No	No	No	No	7	9
256	2x42	4x42	Shared	3.465	2.77	No	Yes	No	No	8	8
257	3x47	5x54	Shared	3.4525	6.13	No	No	No	No	9	9
258	3x44	5x50	Shared	3.2825	6.57	No	No	No	No	8	9
259	3x45	4x45	Shared	3.2825	5.83	No	No	No	No	8	8
260	1x42	7x39	Shared	3.13	4.56	No	No	No	Yes	6	9
261	2x55	2x551	Shared	3.12	4.16	No	No	No	No	5	6
262	4x60	E2.F189	Shared	3.1175	8.32	No	No	Yes	No	8	8
263	2x40	2x43	Shared	3.09	4.12	Yes	Yes	No	No	9	8
264	1x43	2x57	Shared	3.0675	4.6	No	No	Yes	Yes	8	9
265	5x461	Lig	Shared	2.9875	5.03	No	No	Yes	Yes	9	0
266	1x56	8x54	Shared	2.97	7.93	No	No	Yes	Yes	9	9
267	4x61	E2x52	Shared	2.945	4.42	No	No	Yes	Yes	8	7
268	6x50	7x40	Shared	2.8725	4.93	No	No	No	No	9	9
269	5x56	5x60	Shared	2.7675	2.77	No	No	No	No	5	7
270	6x42	6x46	Shared	2.7675	8.3	No	No	No	No	8	5
271	5x36	5x38	Shared	2.735	4.69	Yes	No	No	No	7	5
272	3x26	4x62	Shared	2.715	2.71	No	No	No	No	8	6
273	2x43	7x53	Shared	2.64	14.07	No	No	Yes	No	8	9
274	2x46	3x39	Shared	2.625	3	Yes	Yes	No	No	9	9
275	3x56	I2x52	Shared	2.625	6.01	No	Yes	No	No	7	7
276	1x47	2x51	Shared	2.6075	4.47	No	No	No	No	7	9
277	6x36	7x56	Shared	2.535	6.76	No	No	No	No	9	8
278	4x58	4x59	Shared	2.3375	1.87	No	No	No	No	7	9
279	6x57	E3.I430	Shared	2.3025	6.14	No	No	Yes	No	7	6
280	3x55	3x56	Shared	2.25	4.5	No	No	No	Yes	9	7
281	2x41	4x39	Shared	2.1875	3.75	No	No	No	No	7	6
282	6x54	7x37	Shared	2.185	1.75	No	Yes	No	No	7	7
283	3x34	4x53	Shared	2.0225	1.62	No	No	No	No	8	9
284	2x38	4x39	Shared	1.985	1.59	No	No	No	No	8	6
285	1x45	7x47	Shared	1.9825	3.17	No	No	No	No	5	8
286	3x22	E2.D182	Shared	1.93	1.54	No	No	No	No	4	3
287	4x38	4x41	Shared	1.885	1.51	No	No	No	No	9	8
288	4x63	4x66	Shared	1.8775	2.14	No	No	No	No	7	6
289	1x44	1x48	Shared	1.8625	2.98	No	No	No	No	5	5
290	1x40	1x43	Shared	1.8575	1.86	No	No	No	No	6	8
291	I2x51	I2x52	Shared	1.84	1.47	No	No	No	No	7	7
292	1x35	2x65	Shared	1.84	2.94	No	No	No	No	7	7
293	3x56	I2x50	Shared	1.67	1.67	No	Yes	No	No	7	9
294	6x43	7x48	Shared	1.62	4.87	No	No	No	No	8	7
295	6x32	6x35	Shared	1.5475	1.24	No	No	No	No	9	7
296	2x52	3x31	Shared	1.4275	4.28	No	No	No	No	8	6
297	3x41	4x52	Shared	1.4125	7.07	No	No	No	No	8	6
298	3x54	5x64	Shared	1.275	3.39	No	No	No	No	9	8
299	1x33	1x37	Shared	1.1925	1.59	No	No	No	No	6	5
300	5x55	5x59	Shared	1.14	1.52	No	No	No	No	7	4
301	6x27	6x30	Shared	1.1325	1.51	No	No	Yes	Yes	5	9
302	2x551	3x31	Shared	0.9125	2.44	No	No	No	No	6	6
303	1x36	2x65	Shared	0.81	1.62	No	No	No	No	6	7
304	6x36	6x40	Shared	0.76	3.04	No	No	Yes	No	9	9
305	6x38	6x42	Shared	0.61	2.44	No	No	No	No	8	8
306	4x51	4x55	Shared	0.4	1.6	No	No	No	No	5	5
307	6x52	Lig	m4_off	0	11.4	No	No	Yes	Yes	9	0
308	7x42	Lig	m4_off	0	5.99	Yes	Yes	Yes	Yes	9	0
309	1x27	NT.N25	m4_off	0	11.63	No	No	No	No	0	0
310	1x28	1x32	m4_off	0	5.41	No	No	No	No	0	6
311	1x31	1x35	m4_off	0	4.1	Yes	No	No	No	0	7
312	1x32	2x65	m4_off	0	5.83	No	No	No	No	6	7
313	1x49	7x50	m4_off	0	4.06	No	No	No	No	9	9
314	1x53	7x53	m4_off	0	6.31	No	No	Yes	No	9	9
315	1x56	8x57	m4_off	0	4.5	No	No	No	No	9	0
316	1x57	8x50	m4_off	0	5.02	No	No	Yes	Yes	9	9
317	1x59	CT.Y472	m4_off	0	11.36	No	No	No	No	7	0
318	8x53	I1x50	m4_off	0	5.9	Yes	No	Yes	Yes	9	9
319	2x38	2x42	m4_off	0	5.24	No	No	No	Yes	8	8
320	2x42	4x46	m4_off	0	5.02	No	Yes	No	No	8	9
321	2x44	2x48	m4_off	0	4.19	No	Yes	No	No	8	8
322	2x53	7x42	m4_off	0	4.84	No	Yes	Yes	Yes	9	9
323	2x60	7x39	m4_off	0	4.82	Yes	Yes	No	Yes	8	9
324	2x60	7x42	m4_off	0	5.96	Yes	Yes	Yes	Yes	8	9
325	2x63	E2x50	m4_off	0	5.38	No	No	No	Yes	8	9
326	E1x49	E1x51	m4_off	0	8.34	No	No	No	Yes	5	5
327	E1x51	E1x52	m4_off	0	4.93	No	Yes	No	No	5	7
328	3x26	4x65	m4_off	0	6.53	No	No	No	No	8	7
329	3x29	E2x50	m4_off	0	4.76	No	No	No	Yes	8	9
330	3x32	7x38	m4_off	0	5.75	Yes	Yes	Yes	Yes	9	7
331	3x36	6x48	m4_off	0	4.94	No	No	Yes	Yes	8	9
332	3x43	6x44	m4_off	0	6.09	No	No	Yes	Yes	9	9
333	3x44	5x54	m4_off	0	4.24	No	No	No	No	8	9
334	3x46	6x37	m4_off	0	4.42	No	No	No	No	9	9
335	3x50	3x54	m4_off	0	7.85	No	Yes	No	No	9	9
336	3x50	5x61	m4_off	0	6.26	No	Yes	No	No	9	9
337	3x50	6x30	m4_off	0	8.14	No	Yes	Yes	Yes	9	9
338	3x50	6x33	m4_off	0	7.85	No	Yes	No	No	9	9
339	3x50	6x34	m4_off	0	7.76	No	Yes	No	No	9	9
340	3x53	I2x57	m4_off	0	5.57	No	No	Yes	Yes	9	9
341	4x41	4x45	m4_off	0	7.22	No	No	No	No	8	8
342	4x57	4x61	m4_off	0	4.7	Yes	Yes	No	No	8	8
343	4x68	E2.Q188	m4_off	0	4.3	No	No	Yes	Yes	5	8
344	E2.K177	E2.T179	m4_off	0	4.5	No	No	No	No	3	5
345	E2.N183	E2.P181	m4_off	0	4.89	No	No	No	No	4	3
346	E2.F189	E2.L190	m4_off	0	4.87	Yes	No	No	No	8	5
347	5x43	E2.L190	m4_off	0	4.42	No	No	No	No	9	5
348	5x40	6x55	m4_off	0	4.76	No	No	No	No	8	8
349	5x41	5x45	m4_off	0	10.05	No	No	No	No	7	7
350	5x41	6x59	m4_off	0	5.19	No	No	No	No	7	7
351	5x49	5x53	m4_off	0	5.71	No	No	No	No	8	8
352	5x54	6x41	m4_off	0	5.65	No	No	No	No	9	8
353	5x58	6x38	m4_off	0	19.6	Yes	No	No	No	9	8
354	5x69	6x25	m4_off	0	4.3	No	No	No	No	6	0
355	6x26	6x30	m4_off	0	4.06	No	No	Yes	Yes	0	9
356	6x29	6x30	m4_off	0	5.82	No	No	Yes	Yes	7	9
357	6x40	7x49	m4_off	0	7.08	Yes	No	No	Yes	9	9
358	6x41	6x45	m4_off	0	7.14	No	No	No	No	8	8
359	6x47	6x48	m4_off	0	4.85	No	No	Yes	Yes	9	9
360	6x51	7x34	m4_off	0	6.75	Yes	Yes	No	Yes	9	6
361	6x54	7x33	m4_off	0	4.56	No	Yes	No	No	7	5
362	6x54	7x34	m4_off	0	5.82	No	Yes	No	Yes	7	6
363	6x57	6x60	m4_off	0	5.24	No	No	No	No	7	6
364	7x39	7x42	m4_off	0	6.75	No	Yes	Yes	Yes	9	9
365	8x50	8x54	m4_off	0	4.29	Yes	Yes	Yes	Yes	9	9
366	8x51	8x55	m4_off	0	8.66	No	No	No	No	9	6
367	8x57	CT.Y472	m4_off	0	5.86	No	No	No	No	0	0
368	2x42	3x46	m4_off	0	3.77	No	Yes	No	No	8	9
369	3x50	6x37	m4_off	0	3.76	No	Yes	No	No	9	9
370	6x26	6x31	m4_off	0	3.72	No	No	No	No	0	7
371	6x39	7x52	m4_off	0	3.61	No	No	No	No	9	9
372	2x62	E1x51	m4_off	0	3.53	No	No	No	Yes	8	5
373	3x40	5x50	m4_off	0	3.53	No	No	No	No	9	9
374	E2.P181	E2.V180	m4_off	0	3.53	No	No	No	No	3	5
375	5x42	5x45	m4_off	0	3.53	No	No	No	No	7	7
376	2x49	3x39	m4_off	0	3.42	No	No	No	No	9	9
377	1x53	2x47	m4_off	0	3.39	No	No	No	No	9	9
378	8x56	CT.Y472	m4_off	0	3.27	No	Yes	No	No	6	0
379	5x37	6x58	m4_off	0	3.26	No	No	No	No	5	5
380	3x41	4x49	m4_off	0	3.22	No	No	No	No	8	9
381	3x41	4x53	m4_off	0	3.07	No	No	No	No	8	9
382	5x51	6x45	m4_off	0	3.07	No	No	No	No	8	8
383	5x65	6x26	m4_off	0	3.07	No	No	No	No	9	0
384	7x43	7x48	m4_off	0	3.07	No	No	No	No	6	7
385	1x35	1x39	m4_off	0	3.04	No	No	No	No	7	7
386	7x32	7x36	m4_off	0	3.04	No	No	No	No	4	5
387	5x44	Lig	m4_off	0	3.02	No	No	Yes	Yes	8	0
388	1x38	1x42	m4_off	0	2.98	No	No	No	No	5	6
389	1x48	1x52	m4_off	0	2.98	No	No	No	No	5	8
390	3x23	3x27	m4_off	0	2.98	No	No	No	No	5	7
391	7x40	7x43	m4_off	0	2.98	No	No	No	No	9	6
392	E2.Q188	E2.S191	m4_off	0	2.89	Yes	Yes	No	No	8	7
393	1x51	1x55	m4_off	0	2.85	No	No	No	No	7	6
394	5x59	5x63	m4_off	0	2.85	No	No	No	No	4	4
395	3x21	E1x50	m4_off	0	2.81	No	No	Yes	Yes	8	9
396	6x60	6x61	m4_off	0	2.79	No	No	No	No	6	7
397	4x52	4x56	m4_off	0	2.77	No	No	No	No	6	8
398	7x54	8x54	m4_off	0	2.77	No	No	Yes	Yes	9	9
399	8x52	8x56	m4_off	0	2.62	No	No	No	Yes	6	6
400	2x60	7x35	m4_off	0	2.54	Yes	Yes	No	No	8	6
401	5x58	5x62	m4_off	0	2.54	Yes	No	No	No	9	8
402	4x64	4x67	m4_off	0	2.45	Yes	Yes	No	No	7	5
403	4x42	4x43	m4_off	0	1.95	No	No	No	No	8	5
404	6x39	7x56	m4_off	0	1.81	No	No	No	No	9	8
405	7x36	7x37	m4_off	0	1.76	No	No	No	No	5	7
406	6x61	E3.S428	m4_off	0	1.72	No	No	No	No	7	3
407	1x37	1x41	m4_off	0	1.6	No	No	No	No	5	5
408	5x52	5x56	m4_off	0	1.6	No	No	No	No	5	5
409	6x53	6x57	m4_off	0	1.6	No	No	No	No	7	7
410	5x51	5x55	m4_off	0	1.59	No	No	No	No	8	7
411	2x67	E1x49	m4_off	0	1.45	No	No	No	No	7	5
412	8x60	CT.R473	m4_off	0	1.39	No	No	No	No	0	0
413	8x59	8x61	m4_off	0	1.33	No	No	No	No	0	0
414	5x67	6x31	m4_off	0	1.32	No	No	No	No	6	7
415	5x66	5x69	m4_off	0	1.31	No	No	No	No	7	6
416	1x58	2x44	m4_off	0	1.24	No	No	No	Yes	5	8
417	3x56	I2x56	m4_off	0	1.24	No	Yes	No	No	7	6
418	8x56	8x61	m4_off	0	1.24	No	Yes	No	No	6	0
419	4x62	4x63	m4_off	0	1.22	No	No	No	No	6	7
420	6x25	6x31	m4_off	0	1.17	No	No	No	No	0	7
421	8x55	8x56	m4_off	0	1.13	No	No	No	Yes	6	6

Orange: nodes, hubs and links specific of m4_on network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of m4_off network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	m4_on Avg Int. Strength	m4_off Avg Int. Strength	m4_on Num Of Links	m4_off Num Of Links	ConSurf
1	1x54	m4_on	4.49687	7.72	4	2	8
2	2x66	m4_on	2.961	9.675	5	2	5
3	3x37	m4_on	5.90812	9.555	4	2	9
4	3x49	m4_on	7.79875	10.6333	4	3	9
5	E2.F189	m4_on	6.6575	6.4	4	3	8
6	5x36	m4_on	3.67125	6.74333	4	3	7
7	5x48	m4_on	4.713	8.25	5	1	8
8	5x58	m4_on	5.73208	8.16	6	3	9
9	6x40	m4_on	3.80313	5.38667	4	3	9
10	E3.I430	m4_on	4.55375	10.35	4	3	6
11	7x53	m4_on	5.7335	8.80667	5	3	9
12	8x53	m4_on	2.91812	7.02333	4	3	9
13	1x31	m4_on	1.0075	4.1	4	1	0
14	I1x50	Shared	7.83438	8.366	4	5	9
15	2x40	Shared	4.7625	5.118	5	5	9
16	2x46	Shared	5.187	4.855	5	4	9
17	2x50	Shared	8.20375	7.3	4	4	9
18	2x57	Shared	4.894	6.06	5	5	9
19	2x60	Shared	8.38938	7.53167	4	6	8
20	E1x50	Shared	8.02708	8.38143	6	7	9
21	3x28	Shared	6.1045	9.9425	5	4	7
22	3x32	Shared	7.44438	9.09	4	4	9
23	3x33	Shared	7.9965	12.63	5	4	9
24	3x51	Shared	8.54	6.4	4	4	9
25	I2x53	Shared	9.2155	7.642	5	5	9
26	I2x57	Shared	9.757	9.194	5	5	9
27	4x57	Shared	9.6195	9.5175	5	4	8
28	4x64	Shared	7.5725	5.5975	4	4	7
29	E2.R178	Shared	5.66687	9.9375	4	4	5
30	E2x52	Shared	5.687	7.75	5	4	7
31	E2.Q188	Shared	5.97625	7.6925	4	4	8
32	5x47	Shared	8.35542	10.118	6	5	9
33	6x30	Shared	4.1525	4.8825	4	4	9
34	6x44	Shared	5.0825	8.5625	5	4	9
35	6x48	Shared	6.80464	9.17143	7	7	9
36	6x51	Shared	6.65792	8.0525	6	4	9
37	7x38	Shared	8.819	10.7383	5	6	7
38	7x42	Shared	8.09813	6.475	4	8	9
39	7x45	Shared	8.33875	7.23	4	4	9
40	8x50	Shared	7.35125	7.44	4	5	9
41	8x54	Shared	4.62687	4.66	4	4	9
42	Lig	Shared	6.25821	10.2664	14	11	0
43	2x42	m4_off	4.71	5.84833	3	6	8
44	2x44	m4_off	6.5525	5.4125	2	4	8
45	2x53	m4_off	6.4375	6.235	3	4	9
46	E1x51	m4_off	3.41917	7.116	3	5	5
47	3x50	m4_off	6.2875	6.93667	3	6	9
48	3x56	m4_off	2.18167	3.355	3	4	7
49	E2x50	m4_off	9.0275	6.9675	2	4	9
50	6x54	m4_off	3.09625	4.855	2	4	7
51	7x34	m4_off	6.06417	9.525	3	4	6
52	7x39	m4_off	4.92417	7.28	3	5	9
53	7x49	m4_off	8.83917	7.5475	3	4	9
54	8x56	m4_off	1.0175	2.065	2	4	6

Orange: nodes, hubs and links specific of m4_on network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of m4_off network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	m4_on Recurrence	m4_off Recurrence	m4_on Hub1?	m4_off Hub1?	m4_on Hub2?	m4_off Hub2?	ConSurf1	ConSurf2
1	2x46	3x43	m4_on	100	0	Yes	Yes	No	No	9	9
2	3x43	7x53	m4_on	99.8347	0	No	No	Yes	No	9	9
3	1x60	I1x50	m4_on	18.419	4.03987	No	No	Yes	Yes	8	9
4	1x60	8x53	m4_on	16.4739	0.127143	No	No	Yes	No	8	9
5	3x50	7x53	m4_on	41.4894	0	No	Yes	Yes	No	9	9
6	3x50	5x58	m4_on	41.2456	0	No	Yes	Yes	No	9	9
7	3x47	5x58	m4_on	59.2881	0	No	No	Yes	No	9	9
8	3x47	5x57	m4_on	56.5519	0	No	No	No	No	9	8
9	3x51	5x57	m4_on	48.1998	2.87507	Yes	Yes	No	No	9	8
10	I2x53	I2x57	m4_on	17.8609	0.303503	Yes	Yes	Yes	Yes	9	9
11	5x58	6x40	m4_on	43.2368	0	Yes	No	Yes	No	9	9
12	3x32	Lig	m4_on	23.4064	0	Yes	Yes	Yes	Yes	9	0
13	2x66	E1x51	m4_on	16.2626	4.37208	Yes	No	No	Yes	5	5
14	E2x51	Lig	m4_on	18.9527	0	No	No	Yes	Yes	4	0
15	E2.V180	E2x51	m4_on	18.2564	4.58125	No	No	No	No	5	4
16	3x51	3x55	m4_on	10.9582	8.53498	Yes	Yes	No	No	9	9
17	E2.F189	E2x52	m4_on	13.4343	0	Yes	No	Yes	Yes	8	7
18	5x47	5x48	m4_on	10.8851	2.90788	Yes	Yes	Yes	No	9	8
19	5x58	6x37	m4_on	19.657	0	Yes	No	No	No	9	9
20	5x62	6x37	m4_on	18.3079	0	No	No	No	No	8	9
21	5x62	6x34	m4_on	16.7881	0	No	No	No	No	8	9
22	6x30	6x34	m4_on	10.6439	0	Yes	Yes	No	No	9	9
23	7x34	Lig	m4_on	11.2264	0	No	Yes	Yes	Yes	6	0
24	1x32	2x66	m4_on	10.4841	0	No	No	Yes	No	6	5
25	2x57	7x42	Shared	17.1295	13.0875	Yes	Yes	Yes	Yes	9	9
26	2x53	2x56	Shared	25.7985	14.9947	No	Yes	No	No	9	9
27	2x53	7x46	Shared	25.7822	58.2479	No	Yes	No	No	9	9
28	2x50	7x46	Shared	25.8987	57.8419	Yes	Yes	No	No	9	9
29	2x46	2x50	Shared	26.8767	30.0632	Yes	Yes	Yes	Yes	9	9
30	2x43	7x53	Shared	34.4946	83.0818	No	No	Yes	No	8	9
31	2x40	2x43	Shared	33.6927	81.3674	Yes	Yes	No	No	9	8
32	1x57	2x40	Shared	10.2809	17.1971	No	No	Yes	Yes	9	9
33	2x40	I1x50	Shared	20.1067	28.6441	Yes	Yes	Yes	Yes	9	9
34	1x56	8x53	Shared	11.2101	19.3339	No	No	Yes	No	9	9
35	1x56	8x54	Shared	10.1969	19.7851	No	No	Yes	Yes	9	9
36	3x51	3x52	Shared	33.8688	16.7788	Yes	Yes	No	No	9	7
37	3x52	I2x53	Shared	32.4059	18.124	No	No	Yes	Yes	7	9
38	6x40	7x53	Shared	50.0312	88.0814	Yes	No	Yes	No	9	9
39	3x49	I2x53	Shared	10.1211	21.7825	Yes	No	Yes	Yes	9	9
40	6x48	Lig	Shared	64.1183	89.5497	Yes	Yes	Yes	Yes	9	0
41	6x48	7x45	Shared	66.8193	77.1553	Yes	Yes	Yes	Yes	9	9
42	7x45	7x49	Shared	75.3312	91.1328	Yes	Yes	No	Yes	9	9
43	3x28	3x32	Shared	32.6172	59.872	Yes	Yes	Yes	Yes	7	9
44	3x28	E1x50	Shared	30.6504	100	Yes	Yes	Yes	Yes	7	9
45	E1x50	E1x51	Shared	21.5182	21.7948	Yes	Yes	No	Yes	9	5
46	3x33	E2x52	Shared	14.9432	27.4875	Yes	Yes	Yes	Yes	9	7
47	5x47	6x48	Shared	11.7601	36.9822	Yes	Yes	Yes	Yes	9	9
48	2x56	3x32	Shared	16.5118	14.7855	No	No	Yes	Yes	9	9
49	3x33	Lig	Shared	12.5999	22.0655	Yes	Yes	Yes	Yes	9	0
50	2x46	7x49	Shared	73.8277	42.5396	Yes	Yes	No	Yes	9	9
51	6x51	Lig	m4_off	1.68233	27.4875	Yes	Yes	Yes	Yes	9	0
52	6x51	7x38	m4_off	1.66879	13.9611	Yes	Yes	Yes	Yes	9	7
53	6x52	Lig	m4_off	0	24.8175	No	No	Yes	Yes	9	0
54	7x42	Lig	m4_off	0	48.0477	Yes	Yes	Yes	Yes	9	0
55	1x35	1x39	m4_off	0	10.4503	No	No	No	No	7	7
56	1x39	7x39	m4_off	2.18622	13.9037	No	No	No	Yes	7	9
57	2x60	7x38	m4_off	7.68835	21.5856	Yes	Yes	Yes	Yes	8	7
58	7x39	7x42	m4_off	0	16.6311	No	Yes	Yes	Yes	9	9
59	1x54	2x44	m4_off	8.25454	10.1878	Yes	No	No	Yes	8	8
60	1x57	2x44	m4_off	9.27045	16.1964	No	No	No	Yes	9	8
61	6x40	7x49	m4_off	0	96.4277	Yes	No	No	Yes	9	9
62	2x53	7x42	m4_off	0	46.9896	No	Yes	Yes	Yes	9	9
63	2x50	7x49	m4_off	1.58752	27.9879	Yes	Yes	No	Yes	9	9
64	8x53	I1x50	m4_off	0	21.1508	Yes	No	Yes	Yes	9	9
65	8x50	8x54	m4_off	0	29.3823	Yes	Yes	Yes	Yes	9	9
66	2x40	8x50	m4_off	2.82285	32.4133	Yes	Yes	Yes	Yes	9	9
67	1x56	8x57	m4_off	0	35.1366	No	No	No	No	9	0
68	8x57	CT.Y472	m4_off	0	31.2649	No	No	No	No	0	0
69	2x42	4x46	m4_off	0	64.5681	No	Yes	No	No	8	9
70	2x45	4x46	m4_off	2.11037	65.6017	No	No	No	No	9	9
71	2x45	3x42	m4_off	6.2715	68.6531	No	No	No	No	9	9
72	2x46	3x42	m4_off	7.29824	69.6538	Yes	Yes	No	No	9	9
73	2x42	3x49	m4_off	7.47975	27.0815	No	Yes	Yes	No	8	9
74	3x32	7x38	m4_off	0	18.2307	Yes	Yes	Yes	Yes	9	7
75	2x60	3x28	m4_off	1.19741	48.2118	Yes	Yes	Yes	Yes	8	7
76	3x29	E2x50	m4_off	0	12.6118	No	No	No	Yes	8	9
77	3x29	E2x52	m4_off	3.21567	13.8135	No	No	Yes	Yes	8	7
78	2x63	E2.Q184	m4_off	3.48387	63.4361	No	No	No	No	8	5
79	E2.R178	E2.V180	m4_off	9.73099	40.9605	Yes	Yes	No	No	5	5
80	E2.P181	E2.V180	m4_off	0	49.9754	No	No	No	No	3	5
81	E2.P181	E2.Q184	m4_off	1.1649	54.4213	No	No	No	No	3	5
82	3x26	E2.R178	m4_off	3.72497	22.8037	No	No	Yes	Yes	8	5
83	3x37	4x57	m4_off	0.539105	16.4835	Yes	No	Yes	Yes	9	8
84	3x37	4x53	m4_off	5.15807	14.8716	Yes	No	No	No	9	9
85	5x47	5x51	m4_off	1.12968	67.4596	Yes	Yes	No	No	9	8
86	5x51	6x45	m4_off	0	56.5171	No	No	No	No	8	8
87	6x41	6x45	m4_off	0	37.0519	No	No	No	No	8	8
88	5x54	6x41	m4_off	0	20.2075	No	No	No	No	9	8
89	3x44	5x54	m4_off	0	14.4738	No	No	No	No	8	9
90	5x47	6x52	m4_off	1.78799	24.4894	Yes	Yes	No	No	9	9
91	3x44	5x50	m4_off	3.15607	11.5946	No	No	No	No	8	9
92	2x42	3x46	m4_off	0	24.6739	No	Yes	No	No	8	9
93	3x46	6x37	m4_off	0	23.3533	No	No	No	No	9	9
94	3x50	6x37	m4_off	0	22.0039	No	Yes	No	No	9	9
95	3x50	6x30	m4_off	0	13.9898	No	Yes	Yes	Yes	9	9
96	E2.L190	E2x52	m4_off	2.19706	16.9674	No	No	Yes	Yes	5	7
97	E2.F189	E2.L190	m4_off	0	14.0226	Yes	No	No	No	8	5
98	4x64	E2.F189	m4_off	4.78964	10.963	Yes	Yes	Yes	No	7	8
99	6x51	7x34	m4_off	0	37.3062	Yes	Yes	No	Yes	9	6
100	7x34	E3.I430	m4_off	8.72592	18.3045	No	Yes	Yes	No	6	6
101	6x57	E3.I430	m4_off	2.9556	17.0946	No	No	Yes	No	7	6
102	6x57	6x60	m4_off	0	14.0596	No	No	No	No	7	6
103	5x58	6x41	m4_off	4.56208	14.3138	Yes	No	No	No	9	8
104	6x45	6x49	m4_off	1.63086	17.3448	No	No	No	No	8	7
105	6x49	6x50	m4_off	3.25901	14.4738	No	No	No	No	7	9
106	6x50	7x40	m4_off	1.63086	11.5946	No	No	No	No	9	9
107	8x56	CT.Y472	m4_off	0	23.4968	No	Yes	No	No	6	0
108	3x26	4x62	m4_off	2.83369	18.2758	No	No	No	No	8	6
109	7x38	Lig	m4_off	9.47363	29.4685	Yes	Yes	Yes	Yes	7	0
110	3x32	7x42	m4_off	4.31826	29.4685	Yes	Yes	Yes	Yes	9	9
111	2x60	7x42	m4_off	0	31.3633	Yes	Yes	Yes	Yes	8	9
112	2x63	E1x50	m4_off	1.09988	58.375	No	No	Yes	Yes	8	9
113	4x57	Lig	m4_off	5.05242	14.2236	Yes	Yes	Yes	Yes	8	0
114	6x44	7x45	m4_off	8.36291	14.1334	Yes	Yes	Yes	Yes	9	9
115	5x47	6x44	m4_off	6.27421	13.3705	Yes	Yes	Yes	Yes	9	9

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
3x33	Lig	Shared	20.21	8.555	1	1	1	0
3x36	Lig	Shared	7.67	6.8275	1	0	1	0
4x57	Lig	Shared	8.73	11.5975	1	1	1	0
5x461	Lig	Shared	5.03	2.9875	0	0	1	0
6x48	Lig	Shared	13.09	8.9375	1	1	1	0
6x51	Lig	Shared	12.73	11.1525	1	1	1	0
6x52	Lig	m4_off	11.4	0	0	1	1	0
7x38	Lig	Shared	17.97	7.8575	1	1	1	0
7x41	Lig	Shared	7.09	4.8725	1	1	1	0
7x42	Lig	m4_off	5.99	0	1	1	1	0
2x53	2x56	Shared	7.74	6.19	1	0	2	2
2x53	7x42	m4_off	4.84	0	1	0	2	1
2x56	3x32	Shared	10.31	9.94	1	1	2	1
2x56	7x42	Shared	7.63	6.9975	1	1	2	1
2x57	7x39	Shared	8.14	4.3625	1	0	2	2
2x57	7x42	Shared	4.79	7.78	1	0	2	1
2x60	3x28	Shared	6.75	5.305	1	0	2	2
2x60	7x38	Shared	17.87	17.6225	1	0	2	1
2x60	7x39	m4_off	4.82	0	1	0	2	2
2x60	7x42	m4_off	5.96	0	1	0	2	1
3x28	3x32	Shared	13.4	4.1875	0	0	2	1
3x32	7x38	m4_off	5.75	0	1	1	1	1
3x32	7x42	Shared	6.9	10.915	1	1	1	1
3x33	4x57	Shared	14.47	13.8625	1	1	1	1
3x33	E2x52	Shared	10.88	5.6525	1	1	1	2
3x33	7x38	Shared	4.96	5.46	1	1	1	1
3x36	6x48	m4_off	4.94	0	1	0	1	1
3x37	4x53	Shared	8.94	5.5875	0	1	1	2
3x37	4x57	Shared	10.17	8.475	0	1	1	1
4x57	4x61	m4_off	4.7	0	1	1	1	2
4x61	E2x52	Shared	4.42	2.945	0	0	2	2
E2.V180	E2x51	Shared	11.8	10.4875	0	0	2	1
5x47	5x48	Shared	8.25	9.03	1	1	2	2
5x47	6x44	Shared	4.29	4.825	1	1	2	2
5x47	6x48	Shared	6.01	6.015	1	1	2	1
5x47	6x52	Shared	24.17	17.2175	1	1	2	1
6x44	6x48	Shared	19.04	7.515	1	1	2	1
6x44	7x45	Shared	4.83	4.2275	1	1	2	2
6x47	6x48	m4_off	4.85	0	1	0	2	1
6x47	7x45	Shared	7.31	9.87	1	0	2	2
6x48	7x41	Shared	11.75	8.1625	1	1	1	1
6x48	7x45	Shared	4.52	9.04	1	1	1	2
6x51	7x34	m4_off	6.75	0	1	1	1	1
6x51	7x38	Shared	8.94	6.455	1	1	1	1
6x54	E3.I430	Shared	7.29	4.0075	1	0	2	2
6x54	7x34	m4_off	5.82	0	1	0	2	1
6x58	7x34	Shared	7.91	4.8025	0	0	2	1
7x34	E3.I430	Shared	17.62	8.515	1	0	1	2
7x38	7x42	Shared	8.94	6.7	1	1	1	1
7x39	7x42	m4_off	6.75	0	1	0	2	1
6x51	6x55	Shared	3.79	6.625	1	1	1	2
3x41	4x53	m4_off	3.07	0	0	0	2	2
5x44	Lig	m4_off	3.02	0	0	0	1	0
6x61	E3.S428	m4_off	1.72	0	0	0	2	1
3x32	Lig	m4_on	0	4.735	1	1	1	0
3x33	6x51	m4_on	0	6.4525	1	1	1	1
3x37	3x41	m4_on	0	5.6075	0	1	1	2
3x37	Lig	m4_on	0	3.9625	0	1	1	0
3x40	6x44	m4_on	0	4.5875	0	1	2	2
3x40	6x48	m4_on	0	4.29	0	1	2	1
4x56	4x57	m4_on	0	5.9775	0	0	2	1
4x57	5x43	m4_on	0	8.185	1	1	1	2
6x48	6x52	m4_on	0	3.6725	1	1	1	1
6x51	6x52	m4_on	0	5.2325	1	1	1	1
6x51	7x41	m4_on	0	4.03	1	1	1	1
E2x51	Lig	m4_on	0	7.925	0	0	1	0
7x34	Lig	m4_on	0	4.875	1	0	1	0
7x31	Lig	m4_on	0	2.5575	0	0	1	0
5x44	5x48	m4_on	0	2.0025	0	0	1	2
E3.S428	Lig	m4_on	0	0.7725	0	0	1	0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	m4_off	5DSG-M₄-Tiotropium
	m4_on	7TRS-M₄-Acetylcholine-Gi1/β1/γ2 7V6A-M₄-PubChem 9864275-Gi1/β1/γ2 8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M₄-Iperoxo-Gi1/β1/γ2

Network Difference
Value	m4_on	m4_off
I_min	3.58	4.05
Number of Linked Nodes	277	269
Number of Specific Nodes	16 (5.78%)	8 (2.97%)
Number of Shared Nodes	261 (94.22%)	261 (97.03%)
Number of Links	306	300
Number of Specific Links	121 (39.54%)	115 (38.33%)
Number of Shared Links	185 (60.46%)	185 (61.67%)
Number of Hubs	42	41
Number of Specific Hubs	13 (30.95%)	12 (29.27%)
Number of Shared Hubs	29 (69.05%)	29 (70.73%)
Average % Shared Neighbours (Jaccard)	46.01
Average % Shared Neighbours (Otsuka)	54.17
Average % Shared Neighbours (Overlap Coefficient)	62.48
Average % Shared Cliques (k3-6)	56.88
Graphlets Similarity	0.648413

Paths Difference
Value	m4_on	m4_off
Number Of Nodes in MetaPath	50	82
Specific Nodes in MetaPath	12 (24.00%)	44 (53.66%)
Shared Nodes in MetaPath	261 (94.22%)	261 (94.22%)
Number Of Links MetaPath	50	91
Specific Links in MetaPath	24 (48.00%)	65 (71.43%)
Shared Links in MetaPath	185 (60.46%)	185 (60.46%)
Number of Shortest Paths	63257	68650
Length Of Smallest Path	3	3
Average Path Length	13.963	14.3112
Length of Longest Path	29	30
Minimum Path Strength	0.38625	1.185
Average Path Strength	6.27289	7.57622
Maximum Path Strength	15.1962	18.5933
Minimum Path Correlation	0.7	0.7
Average Path Correlation	0.914977	0.931279
Maximum Path Correlation	0.99	0.99
Minimum % Of Corr. Nodes	3.7037	4.16667
Average % Of Corr. Nodes	41.0424	49.5704
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	49.0896	48.1099
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download m4_off_on.zip<

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