psnGPCR

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Orange: nodes, hubs and links specific of m4_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of m4_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	m4_off Int. Strength	m4_on Int. Strength	m4_off Hub1?	m4_on Hub1?	m4_off Hub2?	m4_on Hub2?	ConSurf1	ConSurf2
1	1x27	NT.N25	m4_off	11.63	0	No	No	No	No	5	7
2	1x28	1x32	m4_off	5.41	0	No	No	No	No	5	6
3	1x31	1x35	m4_off	4.1	0	No	Yes	No	No	6	7
4	1x32	2x65	m4_off	5.83	0	No	No	No	No	6	7
5	1x49	7x50	m4_off	4.06	0	No	No	No	No	9	9
6	1x53	7x53	m4_off	6.31	0	No	No	No	Yes	9	9
7	1x56	8x57	m4_off	4.5	0	No	No	No	No	9	7
8	1x57	8x50	m4_off	5.02	0	No	No	Yes	Yes	9	9
9	1x59	CT.Y472	m4_off	11.36	0	No	No	No	No	7	5
10	8x53	I1x50	m4_off	5.9	0	No	Yes	Yes	Yes	9	9
11	2x38	2x42	m4_off	5.24	0	No	No	Yes	No	8	8
12	2x42	4x46	m4_off	5.02	0	Yes	No	No	No	8	9
13	2x44	2x48	m4_off	4.19	0	Yes	No	No	No	8	8
14	2x53	7x42	m4_off	4.84	0	Yes	No	Yes	Yes	9	9
15	2x60	7x39	m4_off	4.82	0	Yes	Yes	Yes	No	8	9
16	2x60	7x42	m4_off	5.96	0	Yes	Yes	Yes	Yes	8	9
17	2x63	E2x50	m4_off	5.38	0	No	No	Yes	No	8	9
18	E1x49	E1x51	m4_off	8.34	0	No	No	Yes	No	5	5
19	E1x51	E1x52	m4_off	4.93	0	Yes	No	No	No	5	7
20	3x26	4x65	m4_off	6.53	0	No	No	No	No	8	7
21	3x28	E2x50	m4_off	3.92	0	Yes	Yes	Yes	No	7	9
22	3x29	E2x50	m4_off	4.76	0	No	No	Yes	No	8	9
23	3x32	7x38	m4_off	5.75	0	Yes	Yes	Yes	Yes	9	7
24	3x36	6x48	m4_off	4.94	0	No	No	Yes	Yes	8	9
25	3x43	6x44	m4_off	6.09	0	No	No	Yes	Yes	9	9
26	3x44	5x54	m4_off	4.24	0	No	No	No	No	8	9
27	3x46	6x37	m4_off	4.42	0	No	No	No	No	9	9
28	3x50	3x54	m4_off	7.85	0	Yes	No	No	No	9	9
29	3x50	5x61	m4_off	6.26	0	Yes	No	No	No	9	9
30	3x50	6x30	m4_off	8.14	0	Yes	No	Yes	Yes	9	9
31	3x50	6x33	m4_off	7.85	0	Yes	No	No	No	9	9
32	3x50	6x34	m4_off	7.76	0	Yes	No	No	No	9	9
33	3x53	I2x57	m4_off	5.57	0	No	No	Yes	Yes	9	9
34	4x57	4x61	m4_off	4.7	0	Yes	Yes	No	No	8	8
35	4x68	E2.Q188	m4_off	4.3	0	No	No	Yes	Yes	5	8
36	E2.N183	E2.P181	m4_off	4.89	0	No	No	No	No	4	3
37	E2.F189	E2.L190	m4_off	4.87	0	No	Yes	No	No	8	5
38	5x43	E2.L190	m4_off	4.42	0	No	No	No	No	9	5
39	5x40	6x55	m4_off	4.76	0	No	No	No	No	8	8
40	5x41	5x45	m4_off	10.05	0	No	No	No	No	7	7
41	5x41	6x59	m4_off	5.19	0	No	No	No	No	7	7
42	5x49	5x53	m4_off	5.71	0	No	No	No	No	8	8
43	5x54	6x41	m4_off	5.65	0	No	No	No	No	9	8
44	5x58	6x38	m4_off	19.6	0	No	Yes	No	No	9	8
45	5x69	6x25	m4_off	4.3	0	No	No	No	No	6	4
46	6x26	6x30	m4_off	4.06	0	No	No	Yes	Yes	6	9
47	6x29	6x30	m4_off	11.63	0	No	No	Yes	Yes	7	9
48	6x40	7x49	m4_off	7.08	0	No	Yes	Yes	No	9	9
49	6x41	6x45	m4_off	7.14	0	No	No	No	No	8	8
50	6x47	6x48	m4_off	4.85	0	No	No	Yes	Yes	9	9
51	6x51	7x34	m4_off	6.75	0	Yes	Yes	Yes	No	9	6
52	6x52	Lig	m4_off	11.4	0	No	No	Yes	Yes	9	0
53	6x54	7x33	m4_off	4.56	0	Yes	No	No	No	7	5
54	6x54	7x34	m4_off	5.82	0	Yes	No	Yes	No	7	6
55	6x57	6x60	m4_off	5.24	0	No	No	No	No	7	6
56	7x39	7x42	m4_off	6.75	0	Yes	No	Yes	Yes	9	9
57	7x42	Lig	m4_off	5.99	0	Yes	Yes	Yes	Yes	9	0
58	8x50	8x54	m4_off	4.29	0	Yes	Yes	Yes	Yes	9	9
59	8x51	8x55	m4_off	8.66	0	No	No	No	No	9	6
60	8x57	CT.Y472	m4_off	5.86	0	No	No	No	No	7	5
61	2x42	3x46	m4_off	3.77	0	Yes	No	No	No	8	9
62	3x50	6x37	m4_off	3.76	0	Yes	No	No	No	9	9
63	6x26	6x31	m4_off	3.72	0	No	No	No	No	6	7
64	6x39	7x52	m4_off	3.61	0	No	No	No	No	9	9
65	2x62	E1x51	m4_off	3.53	0	No	No	Yes	No	8	5
66	3x40	5x50	m4_off	3.53	0	No	No	No	No	9	9
67	E2.P181	E2.V180	m4_off	3.53	0	No	No	No	No	3	5
68	5x42	5x45	m4_off	3.53	0	No	No	No	No	7	7
69	2x49	3x39	m4_off	3.42	0	No	No	No	No	9	9
70	1x53	2x47	m4_off	3.39	0	No	No	No	No	9	9
71	8x56	CT.Y472	m4_off	3.27	0	Yes	No	No	No	6	5
72	5x37	6x58	m4_off	3.26	0	No	No	No	No	5	5
73	3x41	4x49	m4_off	3.22	0	No	No	No	No	8	9
74	3x41	4x53	m4_off	3.07	0	No	No	No	No	8	9
75	5x51	6x45	m4_off	3.07	0	Yes	No	No	No	8	8
76	5x65	6x26	m4_off	3.07	0	No	No	No	No	9	6
77	7x43	7x48	m4_off	3.07	0	No	No	No	No	6	7
78	1x35	1x39	m4_off	3.04	0	No	No	No	No	7	7
79	7x32	7x36	m4_off	3.04	0	No	No	No	No	4	5
80	5x44	Lig	m4_off	3.02	0	No	No	Yes	Yes	8	0
81	1x38	1x42	m4_off	2.98	0	No	No	No	No	5	6
82	1x48	1x52	m4_off	2.98	0	No	No	No	No	5	8
83	3x23	3x27	m4_off	2.98	0	No	No	No	No	5	7
84	7x40	7x43	m4_off	2.98	0	No	No	No	No	9	6
85	E2.Q188	E2.S191	m4_off	2.89	0	Yes	Yes	No	No	8	7
86	1x51	1x55	m4_off	2.85	0	No	No	No	No	7	6
87	5x59	5x63	m4_off	2.85	0	No	No	No	No	4	4
88	3x21	E1x50	m4_off	2.81	0	No	No	Yes	Yes	8	9
89	6x60	6x61	m4_off	2.79	0	No	No	No	No	6	7
90	4x52	4x56	m4_off	2.77	0	No	No	No	No	6	8
91	7x54	8x54	m4_off	2.77	0	No	No	Yes	Yes	9	9
92	8x59	8x61	m4_off	2.66	0	No	No	No	No	4	6
93	8x52	8x56	m4_off	2.62	0	No	No	Yes	No	6	6
94	2x60	7x35	m4_off	2.54	0	Yes	Yes	No	No	8	6
95	5x58	5x62	m4_off	2.54	0	No	Yes	No	No	9	8
96	4x64	4x67	m4_off	2.45	0	Yes	Yes	No	No	7	5
97	4x42	4x43	m4_off	1.95	0	No	No	No	No	8	5
98	6x39	7x56	m4_off	1.81	0	No	No	No	No	9	8
99	7x36	7x37	m4_off	1.76	0	No	No	No	No	5	7
100	4x69	E2.K177	m4_off	1.74	0	No	No	No	No	4	3
101	6x61	E3.S428	m4_off	1.72	0	No	No	No	No	7	3
102	6x32	7x56	m4_off	1.62	0	No	No	No	No	9	8
103	1x37	1x41	m4_off	1.6	0	No	No	No	No	5	5
104	5x52	5x56	m4_off	1.6	0	No	No	No	No	5	5
105	6x53	6x57	m4_off	1.6	0	No	No	No	No	7	7
106	5x51	5x55	m4_off	1.59	0	Yes	No	No	No	8	7
107	2x67	E1x49	m4_off	1.45	0	No	No	No	No	7	5
108	8x60	CT.R473	m4_off	1.39	0	No	No	No	No	7	5
109	5x67	6x31	m4_off	1.32	0	No	No	No	No	6	7
110	5x66	5x69	m4_off	1.31	0	No	No	No	No	7	6
111	1x58	2x44	m4_off	1.24	0	No	No	Yes	No	5	8
112	8x56	8x61	m4_off	1.24	0	Yes	No	No	No	6	6
113	4x62	4x63	m4_off	1.22	0	No	No	No	No	6	7
114	6x25	6x31	m4_off	1.17	0	No	No	No	No	4	7
115	8x55	8x56	m4_off	1.13	0	No	No	Yes	No	6	6
116	1x34	1x38	Shared	6.55	3.6025	No	No	No	No	4	5
117	1x39	2x61	Shared	6.28	7.065	No	No	No	No	7	8
118	1x39	7x39	Shared	12.13	7.28	No	No	Yes	No	7	9
119	1x42	7x39	Shared	4.56	3.13	No	No	Yes	No	6	9
120	1x43	2x57	Shared	4.6	3.0675	No	No	Yes	Yes	8	9
121	1x43	2x58	Shared	7.45	5.215	No	No	No	No	8	9
122	1x46	2x57	Shared	7.53	4.895	No	No	Yes	Yes	8	9
123	1x46	7x47	Shared	9.42	10.205	No	No	No	No	8	8
124	1x47	2x51	Shared	4.47	2.6075	No	No	No	No	7	9
125	1x50	2x50	Shared	6.73	8.0775	No	No	Yes	Yes	9	9
126	1x50	7x50	Shared	11.4	6.1125	No	No	No	No	9	9
127	1x51	2x51	Shared	4.28	4.2825	No	No	No	No	7	9
128	1x54	2x44	Shared	11.2	8.395	No	Yes	Yes	No	8	8
129	1x54	2x51	Shared	4.24	3.535	No	Yes	No	No	8	9
130	1x56	8x53	Shared	6.4	5.1975	No	No	No	Yes	9	9
131	1x56	8x54	Shared	7.93	2.97	No	No	Yes	Yes	9	9
132	1x57	2x40	Shared	4.25	5.6625	No	No	Yes	Yes	9	9
133	1x57	2x44	Shared	5.02	4.71	No	No	Yes	No	9	8
134	1x60	I1x49	Shared	7.92	3.63	No	No	No	No	8	6
135	1x60	I1x50	Shared	13.73	10.64	No	No	Yes	Yes	8	9
136	1x60	8x53	Shared	8.77	3.6575	No	No	No	Yes	8	9
137	2x40	I1x50	Shared	4.12	3.7775	Yes	Yes	Yes	Yes	9	9
138	8x49	I1x50	Shared	5.9	6.2625	No	No	Yes	Yes	8	9
139	8x50	I1x50	Shared	12.18	10.6575	Yes	Yes	Yes	Yes	9	9
140	2x37	2x40	Shared	5.85	5.8475	No	No	Yes	Yes	8	9
141	2x38	I2x57	Shared	10.46	10.7875	No	No	Yes	Yes	8	9
142	2x39	3x49	Shared	4.04	6.7325	No	No	Yes	Yes	9	9
143	2x39	I2x57	Shared	9.64	8.4375	No	No	Yes	Yes	9	9
144	2x40	2x43	Shared	4.12	3.09	Yes	Yes	No	No	9	8
145	2x40	8x50	Shared	7.25	5.435	Yes	Yes	Yes	Yes	9	9
146	2x42	3x45	Shared	7.54	4.395	Yes	No	No	No	8	8
147	2x42	3x49	Shared	10.75	6.27	Yes	No	Yes	Yes	8	9
148	2x43	7x53	Shared	14.07	2.64	No	No	No	Yes	8	9
149	2x45	3x42	Shared	8.94	9.3125	No	No	No	No	9	9
150	2x45	4x46	Shared	9.29	6.9675	No	No	No	No	9	9
151	2x45	4x50	Shared	6.18	4.9425	No	No	No	No	9	9
152	2x46	2x50	Shared	5.43	6.445	Yes	Yes	Yes	Yes	9	9
153	2x46	3x42	Shared	6.87	4.4625	Yes	Yes	No	No	9	9
154	2x46	7x49	Shared	4.12	7.21	Yes	Yes	Yes	No	9	9
155	2x50	7x46	Shared	10.31	9.2025	Yes	Yes	No	No	9	9
156	2x50	7x49	Shared	6.73	9.09	Yes	Yes	Yes	No	9	9
157	2x52	3x31	Shared	4.28	1.4275	No	No	No	No	8	6
158	2x52	3x35	Shared	6.14	6.5275	No	No	No	No	8	8
159	2x53	2x56	Shared	7.74	6.19	Yes	No	No	No	9	9
160	2x53	7x46	Shared	9.29	8.515	Yes	No	No	No	9	9
161	2x54	2x57	Shared	5.24	4.365	No	No	Yes	Yes	9	9
162	2x55	2x551	Shared	4.16	3.12	No	No	No	No	5	6
163	2x56	3x32	Shared	10.31	9.94	No	No	Yes	Yes	9	9
164	2x56	7x42	Shared	7.63	6.9975	No	No	Yes	Yes	9	9
165	2x57	7x39	Shared	8.14	4.3625	Yes	Yes	Yes	No	9	9
166	2x57	7x42	Shared	4.79	7.78	Yes	Yes	Yes	Yes	9	9
167	2x59	3x28	Shared	10.25	10.535	No	No	Yes	Yes	7	7
168	2x60	2x64	Shared	7.25	3.93	Yes	Yes	No	No	8	7
169	2x60	3x28	Shared	6.75	5.305	Yes	Yes	Yes	Yes	8	7
170	2x60	7x38	Shared	17.87	17.6225	Yes	Yes	Yes	Yes	8	7
171	2x63	E1x50	Shared	10.61	7.96	No	No	Yes	Yes	8	9
172	2x63	E2.Q184	Shared	6.76	3.66	No	No	No	No	8	5
173	2x66	E1x49	Shared	5.97	5.6725	No	Yes	No	No	5	5
174	2x66	E1x51	Shared	13.38	4.6	No	Yes	Yes	No	5	5
175	E1x50	E1x51	Shared	5.4	4.3875	Yes	Yes	Yes	No	9	5
176	E1x50	E1x52	Shared	14.81	11.3875	Yes	Yes	No	No	9	7
177	3x25	E1x50	Shared	5.22	6.8575	No	No	Yes	Yes	9	9
178	3x28	E1x50	Shared	9.37	6.795	Yes	Yes	Yes	Yes	7	9
179	E1x50	E2x50	Shared	10.45	10.775	Yes	Yes	Yes	No	9	9
180	3x24	E1x52	Shared	5.96	4.8425	No	No	No	No	6	7
181	3x22	E2.R178	Shared	6.91	4.495	No	No	Yes	Yes	4	5
182	3x25	E2x50	Shared	7.28	7.28	No	No	Yes	No	9	9
183	3x26	E2.R178	Shared	9.53	6.5525	No	No	Yes	Yes	8	5
184	3x28	3x32	Shared	13.4	4.1875	Yes	Yes	Yes	Yes	7	9
185	3x29	E2x52	Shared	5.71	6.4225	No	No	Yes	Yes	8	7
186	3x32	7x42	Shared	6.9	10.915	Yes	Yes	Yes	Yes	9	9
187	3x33	4x57	Shared	14.47	13.8625	Yes	Yes	Yes	Yes	9	8
188	3x33	E2x52	Shared	10.88	5.6525	Yes	Yes	Yes	Yes	9	7
189	3x33	7x38	Shared	4.96	5.46	Yes	Yes	Yes	Yes	9	7
190	3x33	Lig	Shared	20.21	8.63	Yes	Yes	Yes	Yes	9	0
191	3x34	4x54	Shared	3.93	4.2575	No	No	No	No	8	7
192	3x36	Lig	Shared	7.67	6.8575	No	No	Yes	Yes	8	0
193	3x37	4x53	Shared	8.94	5.5875	No	Yes	No	No	9	9
194	3x37	4x57	Shared	10.17	8.475	No	Yes	Yes	Yes	9	8
195	3x38	4x50	Shared	9.08	8.105	No	No	No	No	9	9
196	3x41	4x52	Shared	7.07	1.4125	No	No	No	No	8	6
197	3x44	5x50	Shared	6.57	3.2825	No	No	No	No	8	9
198	3x45	4x45	Shared	5.83	3.2825	No	No	No	No	8	8
199	3x47	5x54	Shared	6.13	3.4525	No	No	No	No	9	9
200	3x48	5x57	Shared	12.18	7.9175	No	No	No	No	7	8
201	3x49	I2x53	Shared	8.05	7.4725	Yes	Yes	Yes	Yes	9	9
202	3x49	I2x57	Shared	13.1	10.72	Yes	Yes	Yes	Yes	9	9
203	3x51	3x52	Shared	5.16	4.9	Yes	Yes	No	No	9	7
204	3x51	3x55	Shared	12.48	14.355	Yes	Yes	No	No	9	9
205	3x51	5x57	Shared	4.69	10.55	Yes	Yes	No	No	9	8
206	3x52	I2x53	Shared	13.41	13.4125	No	No	Yes	Yes	7	9
207	3x53	I2x53	Shared	5.38	3.695	No	No	Yes	Yes	9	9
208	3x54	5x61	Shared	6.14	5.3775	No	No	No	No	9	9
209	3x55	3x56	Shared	4.5	2.25	No	No	No	No	9	7
210	3x56	I2x52	Shared	6.01	2.625	No	No	No	No	7	7
211	I2x53	I2x54	Shared	4.17	4.5175	Yes	Yes	No	No	9	7
212	I2x53	I2x57	Shared	7.2	16.98	Yes	Yes	Yes	Yes	9	9
213	4x38	4x41	Shared	4.52	1.885	No	No	No	No	9	8
214	4x54	4x58	Shared	8.32	4.505	No	No	No	No	7	7
215	4x57	Lig	Shared	8.73	11.645	Yes	Yes	Yes	Yes	8	0
216	4x60	E2.F189	Shared	8.32	3.1175	No	No	No	Yes	8	8
217	4x61	E2x52	Shared	4.42	2.945	No	No	Yes	Yes	8	7
218	4x64	4x68	Shared	7.36	8.58	Yes	Yes	No	No	7	5
219	4x64	E2.Q188	Shared	6.57	7.395	Yes	Yes	Yes	Yes	7	8
220	4x64	E2.F189	Shared	6.01	10.0225	Yes	Yes	No	Yes	7	8
221	4x65	E2.R178	Shared	12.85	6.7175	No	No	Yes	Yes	7	5
222	E2.R178	E2.V180	Shared	10.46	4.9025	Yes	Yes	No	No	5	5
223	E2.Q188	E2.T179	Shared	17.01	6.7325	Yes	Yes	No	No	8	5
224	E2.V180	E2x51	Shared	11.8	10.4875	No	No	No	No	5	4
225	E2.P181	E2.Q184	Shared	7.9	4.7375	No	No	No	No	3	5
226	E2.N183	E2.Q184	Shared	11.88	3.63	No	No	No	No	4	5
227	E2.L190	E2x52	Shared	9.99	7.135	No	No	Yes	Yes	5	7
228	5x36	5x37	Shared	8.15	5.2975	No	Yes	No	No	7	5
229	5x36	5x38	Shared	4.69	2.735	No	Yes	No	No	7	5
230	5x36	5x39	Shared	7.39	6.28	No	Yes	No	No	7	8
231	5x41	6x56	Shared	8.53	6.0875	No	No	No	No	7	7
232	5x461	Lig	Shared	5.03	3.0025	No	No	Yes	Yes	9	0
233	5x47	5x48	Shared	8.25	9.03	Yes	Yes	No	Yes	9	8
234	5x47	5x51	Shared	7.87	6.8825	Yes	Yes	Yes	No	9	8
235	5x47	6x44	Shared	4.29	4.825	Yes	Yes	Yes	Yes	9	9
236	5x47	6x48	Shared	6.01	6.015	Yes	Yes	Yes	Yes	9	9
237	5x47	6x52	Shared	24.17	17.2175	Yes	Yes	No	No	9	9
238	5x51	6x44	Shared	3.93	4.2575	Yes	No	Yes	Yes	8	9
239	6x32	6x35	Shared	4.95	1.5475	No	No	No	No	9	7
240	6x36	7x56	Shared	6.76	2.535	No	No	No	No	9	8
241	6x40	7x53	Shared	6.04	7.2525	No	Yes	No	Yes	9	9
242	6x42	6x46	Shared	8.3	2.7675	No	No	No	No	8	5
243	6x43	7x48	Shared	4.87	1.62	No	No	No	No	8	7
244	6x44	6x48	Shared	19.04	7.515	Yes	Yes	Yes	Yes	9	9
245	6x44	7x45	Shared	4.83	4.2275	Yes	Yes	Yes	Yes	9	9
246	6x47	7x45	Shared	7.31	9.87	No	No	Yes	Yes	9	9
247	6x48	7x41	Shared	11.75	8.1625	Yes	Yes	No	No	9	9
248	6x48	7x45	Shared	4.52	9.04	Yes	Yes	Yes	Yes	9	9
249	6x48	Lig	Shared	13.09	8.99	Yes	Yes	Yes	Yes	9	0
250	6x50	7x40	Shared	4.93	2.8725	No	No	No	No	9	9
251	6x51	6x55	Shared	3.79	6.625	Yes	Yes	No	No	9	8
252	6x51	7x38	Shared	8.94	6.455	Yes	Yes	Yes	Yes	9	7
253	6x51	7x41	Shared	4.03	4.03	Yes	Yes	No	No	9	9
254	6x51	Lig	Shared	12.73	11.2	Yes	Yes	Yes	Yes	9	0
255	6x54	E3.I430	Shared	7.29	4.0075	Yes	No	No	Yes	7	6
256	6x57	E3.I430	Shared	6.14	2.3025	No	No	No	Yes	7	6
257	6x58	E3.Q427	Shared	6.6	6.6025	No	No	No	No	5	3
258	6x58	7x34	Shared	7.91	4.8025	No	No	Yes	No	5	6
259	6x59	6x60	Shared	5.19	5.5125	No	No	No	No	7	6
260	6x61	E3.C429	Shared	7.28	7.28	No	No	No	No	7	7
261	7x34	E3.I430	Shared	17.62	8.515	Yes	No	No	Yes	6	6
262	7x30	7x33	Shared	7.07	6.1825	No	No	No	No	6	5
263	7x38	7x42	Shared	8.94	6.7	Yes	Yes	Yes	Yes	7	9
264	7x38	Lig	Shared	17.97	7.9225	Yes	Yes	Yes	Yes	7	0
265	7x41	Lig	Shared	7.09	4.9125	No	No	Yes	Yes	9	0
266	7x45	7x49	Shared	12.26	10.2175	Yes	Yes	Yes	No	9	9
267	8x47	8x49	Shared	4.39	5.85	No	No	No	No	9	8
268	8x47	8x50	Shared	8.46	8.4575	No	No	Yes	Yes	9	9
269	2x41	4x39	Shared	3.75	2.1875	No	No	No	No	7	6
270	1x52	8x54	Shared	3.65	7.9175	No	No	Yes	Yes	8	9
271	6x49	6x50	Shared	3.5	3.5	No	No	No	No	7	9
272	3x54	5x64	Shared	3.39	1.275	No	No	No	No	9	8
273	5x49	5x50	Shared	3.28	3.6925	No	No	No	No	8	9
274	3x51	5x60	Shared	3.27	4.355	Yes	Yes	No	No	9	7
275	1x45	7x47	Shared	3.17	1.9825	No	No	No	No	5	8
276	2x53	3x35	Shared	3.07	4.6075	Yes	No	No	No	9	8
277	6x36	6x40	Shared	3.04	0.76	No	No	No	Yes	9	9
278	6x45	6x49	Shared	3.04	5.32	No	No	No	No	8	7
279	2x46	3x39	Shared	3	2.625	Yes	Yes	No	No	9	9
280	1x44	1x48	Shared	2.98	1.8625	No	No	No	No	5	5
281	1x35	2x65	Shared	2.94	1.84	No	No	No	No	7	7
282	2x42	4x42	Shared	2.77	3.465	Yes	No	No	No	8	8
283	5x56	5x60	Shared	2.77	2.7675	No	No	No	No	5	7
284	3x26	4x62	Shared	2.71	2.715	No	No	No	No	8	6
285	2x551	3x31	Shared	2.44	0.9125	No	No	No	No	6	6
286	6x38	6x42	Shared	2.44	0.61	No	No	No	No	8	8
287	5x58	6x41	Shared	2.34	4.1025	No	Yes	No	No	9	8
288	4x63	4x66	Shared	2.14	1.8775	No	No	No	No	7	6
289	4x58	4x59	Shared	1.87	2.3375	No	No	No	No	7	9
290	1x40	1x43	Shared	1.86	1.8575	No	No	No	No	6	8
291	6x54	7x37	Shared	1.75	2.185	Yes	No	No	No	7	7
292	3x56	I2x50	Shared	1.67	1.67	No	No	No	No	7	9
293	1x36	2x65	Shared	1.62	0.81	No	No	No	No	6	7
294	3x34	4x53	Shared	1.62	2.0225	No	No	No	No	8	9
295	8x48	8x52	Shared	1.61	0.8025	No	No	No	No	5	6
296	4x51	4x55	Shared	1.6	0.4	No	No	No	No	5	5
297	1x33	1x37	Shared	1.59	1.1925	No	No	No	No	6	5
298	2x38	4x39	Shared	1.59	1.985	No	No	No	No	8	6
299	3x30	4x62	Shared	1.58	3.5475	No	No	No	No	8	6
300	3x22	E2.D182	Shared	1.54	1.93	No	No	No	No	4	3
301	4x68	E2.K177	Shared	1.52	1.8975	No	No	No	No	5	3
302	5x55	5x59	Shared	1.52	1.14	No	No	No	No	7	4
303	6x27	6x30	Shared	1.51	1.1325	No	No	Yes	Yes	5	9
304	4x38	4x40	Shared	1.5	4.13	No	No	No	No	9	6
305	I2x51	I2x52	Shared	1.47	1.84	No	No	No	No	7	7
306	I1x48	I1x51	m4_on	0	7.885	No	No	No	No	8	8
307	2x46	3x43	m4_on	0	5.1925	Yes	Yes	No	No	9	9
308	2x60	2x63	m4_on	0	6.7	Yes	Yes	No	No	8	8
309	3x28	3x29	m4_on	0	3.7	Yes	Yes	No	No	7	8
310	3x32	Lig	m4_on	0	4.765	Yes	Yes	Yes	Yes	9	0
311	3x33	6x51	m4_on	0	6.4525	Yes	Yes	Yes	Yes	9	9
312	3x37	3x41	m4_on	0	5.6075	No	Yes	No	No	9	8
313	3x37	Lig	m4_on	0	3.9725	No	Yes	Yes	Yes	9	0
314	3x40	6x44	m4_on	0	4.5875	No	No	Yes	Yes	9	9
315	3x40	6x48	m4_on	0	4.29	No	No	Yes	Yes	9	9
316	3x43	7x53	m4_on	0	6.74	No	No	No	Yes	9	9
317	3x44	3x48	m4_on	0	5.175	No	No	No	No	8	7
318	3x46	3x50	m4_on	0	6.2625	No	No	Yes	No	9	9
319	3x46	7x53	m4_on	0	4.835	No	No	No	Yes	9	9
320	3x47	5x57	m4_on	0	5.2575	No	No	No	No	9	8
321	3x47	5x58	m4_on	0	8.2675	No	No	No	Yes	9	9
322	3x50	5x58	m4_on	0	5.4	Yes	No	No	Yes	9	9
323	3x50	7x53	m4_on	0	7.2	Yes	No	No	Yes	9	9
324	4x56	4x57	m4_on	0	5.9775	No	No	Yes	Yes	8	8
325	4x57	5x43	m4_on	0	8.185	Yes	Yes	No	No	8	9
326	4x64	5x39	m4_on	0	4.2925	Yes	Yes	No	No	7	8
327	4x65	4x66	m4_on	0	11.7125	No	No	No	No	7	6
328	4x65	E2.Q188	m4_on	0	5.12	No	No	Yes	Yes	7	8
329	E2.Q188	E2.V180	m4_on	0	4.6575	Yes	Yes	No	No	8	5
330	E2.F189	E2x52	m4_on	0	6.28	No	Yes	Yes	Yes	8	7
331	5x39	E2.F189	m4_on	0	7.21	No	No	No	Yes	8	8
332	5x40	E2.L190	m4_on	0	4.055	No	No	No	No	8	5
333	5x37	6x59	m4_on	0	5.2475	No	No	No	No	5	7
334	5x45	5x48	m4_on	0	4.5325	No	No	No	Yes	7	8
335	5x47	6x49	m4_on	0	6.1625	Yes	Yes	No	No	9	7
336	5x48	6x56	m4_on	0	6.74	No	Yes	No	No	8	7
337	5x58	5x61	m4_on	0	3.63	No	Yes	No	No	9	9
338	5x58	6x37	m4_on	0	9.065	No	Yes	No	No	9	9
339	5x58	6x40	m4_on	0	3.9275	No	Yes	No	Yes	9	9
340	5x62	6x34	m4_on	0	5.1975	No	No	No	No	8	9
341	5x65	6x33	m4_on	0	5.2525	No	No	No	No	9	9
342	5x66	6x30	m4_on	0	11.92	No	No	Yes	Yes	7	9
343	6x48	6x52	m4_on	0	3.6725	Yes	Yes	No	No	9	9
344	6x51	6x52	m4_on	0	5.2325	Yes	Yes	No	No	9	9
345	7x54	8x50	m4_on	0	4.855	No	No	Yes	Yes	9	9
346	7x55	8x54	m4_on	0	5.4825	No	No	Yes	Yes	8	9
347	8x52	8x55	m4_on	0	4.6425	No	No	No	No	6	6
348	E2x51	Lig	m4_on	0	7.925	No	No	Yes	Yes	4	0
349	7x34	Lig	m4_on	0	4.875	Yes	No	Yes	Yes	6	0
350	4x41	4x44	m4_on	0	3.5325	No	No	No	No	8	3
351	5x66	5x68	m4_on	0	3.465	No	No	No	No	7	8
352	7x30	E3.I430	m4_on	0	3.39	No	No	No	Yes	6	6
353	6x40	7x52	m4_on	0	3.2725	No	Yes	No	No	9	9
354	1x54	2x48	m4_on	0	3.24	No	Yes	No	No	8	8
355	3x44	5x53	m4_on	0	3.2075	No	No	No	No	8	8
356	2x64	7x35	m4_on	0	3.095	No	No	No	No	7	6
357	1x53	7x50	m4_on	0	3.0925	No	No	No	No	9	9
358	1x54	2x47	m4_on	0	2.8175	No	Yes	No	No	8	9
359	2x62	2x66	m4_on	0	2.6575	No	No	No	Yes	8	5
360	1x55	1x59	m4_on	0	2.6075	No	No	No	No	6	7
361	6x34	6x38	m4_on	0	2.5925	No	No	No	No	9	8
362	2x49	4x50	m4_on	0	2.59	No	No	No	No	9	9
363	5x55	6x41	m4_on	0	2.58	No	No	No	No	7	8
364	7x31	Lig	m4_on	0	2.5575	No	No	Yes	Yes	3	0
365	8x55	8x58	m4_on	0	2.43	No	No	No	No	6	8
366	6x31	6x35	m4_on	0	2.4	No	No	No	No	7	7
367	6x47	7x43	m4_on	0	2.38	No	No	No	No	9	6
368	6x32	6x36	m4_on	0	2.2525	No	No	No	No	9	9
369	8x54	8x55	m4_on	0	2.1375	Yes	Yes	No	No	9	6
370	7x55	8x51	m4_on	0	2.115	No	No	No	No	8	9
371	3x45	4x49	m4_on	0	2.0275	No	No	No	No	8	9
372	5x44	5x48	m4_on	0	2.0025	No	No	No	Yes	8	8
373	5x67	6x29	m4_on	0	1.9775	No	No	No	No	6	7
374	7x35	7x36	m4_on	0	1.9375	No	No	No	No	6	5
375	4x41	I2x57	m4_on	0	1.86	No	No	Yes	Yes	8	9
376	5x63	5x66	m4_on	0	1.82	No	No	No	No	4	7
377	5x65	6x30	m4_on	0	1.795	No	No	Yes	Yes	9	9
378	6x30	6x34	m4_on	0	1.7625	Yes	Yes	No	No	9	9
379	4x43	4x46	m4_on	0	1.76	No	No	No	No	5	9
380	3x27	4x62	m4_on	0	1.7275	No	No	No	No	7	6
381	8x53	8x56	m4_on	0	1.7125	No	Yes	Yes	No	9	6
382	1x49	1x52	m4_on	0	1.71	No	No	No	No	9	8
383	6x57	6x61	m4_on	0	1.7075	No	No	No	No	7	7
384	2x41	I1x51	m4_on	0	1.69	No	No	No	No	7	8
385	7x48	7x52	m4_on	0	1.6375	No	No	No	No	7	9
386	5x67	5x69	m4_on	0	1.615	No	No	No	No	6	6
387	1x47	1x48	m4_on	0	1.6	No	No	No	No	7	5
388	5x62	6x37	m4_on	0	1.55	No	No	No	No	8	9
389	1x32	2x66	m4_on	0	1.44	No	No	No	Yes	6	5
390	1x30	1x31	m4_on	0	1.425	No	No	No	Yes	4	6
391	6x28	6x31	m4_on	0	1.3825	No	No	No	No	6	7
392	3x21	3x24	m4_on	0	1.38	No	No	No	No	8	6
393	1x58	I1x51	m4_on	0	1.3575	No	No	No	No	5	8
394	7x30	7x32	m4_on	0	1.3125	No	No	No	No	6	4
395	4x63	4x67	m4_on	0	1.31	No	No	No	No	7	5
396	I2x52	I2x56	m4_on	0	1.2925	No	No	No	No	7	6
397	2x65	E1x51	m4_on	0	1.27	No	No	Yes	No	7	5
398	1x26	1x31	m4_on	0	1.2675	No	No	No	Yes	4	6
399	5x48	6x53	m4_on	0	1.26	No	Yes	No	No	8	7
400	4x56	5x46	m4_on	0	1.1825	No	No	No	No	8	7
401	5x41	5x42	m4_on	0	1.1325	No	No	No	No	7	7
402	8x53	8x57	m4_on	0	1.105	No	Yes	No	No	9	7
403	1x29	1x31	m4_on	0	1.0575	No	No	No	Yes	4	6
404	6x26	6x29	m4_on	0	0.93	No	No	No	No	6	7
405	6x29	6x32	m4_on	0	0.9275	No	No	No	No	7	9
406	4x68	4x69	m4_on	0	0.92	No	No	No	No	5	4
407	E3.S428	Lig	m4_on	0	0.7725	No	No	Yes	Yes	3	0
408	1x32	1x33	m4_on	0	0.76	No	No	No	No	6	6
409	1x29	1x32	m4_on	0	0.7525	No	No	No	No	4	6
410	1x41	1x42	m4_on	0	0.75	No	No	No	No	5	6
411	1x59	8x57	m4_on	0	0.745	No	No	No	No	7	7
412	2x66	2x67	m4_on	0	0.435	No	Yes	No	No	5	7
413	1x38	1x41	m4_on	0	0.405	No	No	No	No	5	5
414	3x23	3x24	m4_on	0	0.4	No	No	No	No	5	6
415	5x51	5x52	m4_on	0	0.4	Yes	No	No	No	8	5
416	7x51	7x55	m4_on	0	0.395	No	No	No	No	7	8
417	5x36	E2.S191	m4_on	0	0.3725	No	Yes	No	No	7	7
418	4x55	4x56	m4_on	0	0.3725	No	No	No	No	5	8
419	I2x55	I2x56	m4_on	0	0.345	No	No	No	No	6	6
420	8x56	8x59	m4_on	0	0.3225	Yes	No	No	No	6	4
421	1x27	1x31	m4_on	0	0.28	No	No	No	Yes	5	6

Orange: nodes, hubs and links specific of m4_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of m4_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	m4_off Avg Int. Strength	m4_on Avg Int. Strength	m4_off Num Of Links	m4_on Num Of Links	ConSurf
1	2x42	m4_off	5.84833	4.71	6	3	8
2	2x44	m4_off	5.4125	6.5525	4	2	8
3	2x53	m4_off	6.235	6.4375	4	3	9
4	E1x51	m4_off	7.116	3.41917	5	3	5
5	3x50	m4_off	6.93667	6.2875	6	3	9
6	E2x50	m4_off	6.358	9.0275	5	2	9
7	5x51	m4_off	4.115	3.84667	4	3	8
8	6x54	m4_off	4.855	3.09625	4	2	7
9	7x34	m4_off	9.525	6.06417	4	3	6
10	7x39	m4_off	7.28	4.92417	5	3	9
11	7x49	m4_off	7.5475	8.83917	4	3	9
12	8x56	m4_off	2.065	1.0175	4	2	6
13	I1x50	Shared	8.366	7.83438	5	4	9
14	2x40	Shared	5.118	4.7625	5	5	9
15	2x46	Shared	4.855	5.187	4	5	9
16	2x50	Shared	7.3	8.20375	4	4	9
17	2x57	Shared	6.06	4.894	5	5	9
18	2x60	Shared	7.53167	8.38938	6	4	8
19	E1x50	Shared	8.38143	8.02708	7	6	9
20	3x28	Shared	8.738	6.1045	5	5	7
21	3x32	Shared	9.09	7.45187	4	4	9
22	3x33	Shared	12.63	8.0115	4	5	9
23	3x49	Shared	8.985	7.79875	4	4	9
24	3x51	Shared	6.4	8.54	4	4	9
25	I2x53	Shared	7.642	9.2155	5	5	9
26	I2x57	Shared	9.194	9.757	5	5	9
27	4x57	Shared	9.5175	9.629	4	5	8
28	4x64	Shared	5.5975	7.5725	4	4	7
29	E2.R178	Shared	9.9375	5.66687	4	4	5
30	E2x52	Shared	7.75	5.687	4	5	7
31	E2.Q188	Shared	7.6925	5.97625	4	4	8
32	5x47	Shared	10.118	8.35542	5	6	9
33	6x30	Shared	6.335	4.1525	4	4	9
34	6x44	Shared	7.636	5.0825	5	5	9
35	6x48	Shared	9.17143	6.81214	7	7	9
36	6x51	Shared	7.248	6.66583	5	6	9
37	7x38	Shared	10.7383	8.832	6	5	7
38	7x42	Shared	6.475	8.09813	8	4	9
39	7x45	Shared	7.23	8.33875	4	4	9
40	8x50	Shared	7.44	7.35125	5	4	9
41	8x54	Shared	4.66	4.62687	4	4	9
42	Lig	Shared	10.2664	6.28768	11	14	0
43	1x54	m4_on	7.72	4.49687	2	4	8
44	2x66	m4_on	9.675	2.961	2	5	5
45	3x37	m4_on	9.555	5.91062	2	4	9
46	E2.F189	m4_on	6.4	6.6575	3	4	8
47	5x36	m4_on	6.74333	3.67125	3	4	7
48	5x48	m4_on	8.25	4.713	1	5	8
49	5x58	m4_on	8.16	5.73208	3	6	9
50	6x40	m4_on	5.38667	3.80313	3	4	9
51	E3.I430	m4_on	10.35	4.55375	3	4	6
52	7x53	m4_on	8.80667	5.7335	3	5	9
53	8x53	m4_on	7.02333	2.91812	3	4	9
54	1x31	m4_on	4.1	1.0075	1	4	6

Orange: nodes, hubs and links specific of m4_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of m4_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	m4_off Recurrence	m4_on Recurrence	m4_off Hub1?	m4_on Hub1?	m4_off Hub2?	m4_on Hub2?	ConSurf1	ConSurf2
1	1x39	7x39	m4_off	10.5744	2.18622	No	No	Yes	No	7	9
2	7x39	7x42	m4_off	12.4006	0	Yes	No	Yes	Yes	9	9
3	2x53	7x42	m4_off	43.9767	0	Yes	No	Yes	Yes	9	9
4	2x50	7x49	m4_off	28.861	1.58752	Yes	Yes	Yes	No	9	9
5	6x40	7x49	m4_off	90.5127	0	No	Yes	Yes	No	9	9
6	1x57	2x44	m4_off	13.9435	9.27045	No	No	Yes	No	9	8
7	7x42	Lig	m4_off	53.6282	0	Yes	Yes	Yes	Yes	9	0
8	8x53	I1x50	m4_off	20.0334	0	No	Yes	Yes	Yes	9	9
9	2x40	8x50	m4_off	29.8576	2.82285	Yes	Yes	Yes	Yes	9	9
10	8x50	8x54	m4_off	27.1114	0	Yes	Yes	Yes	Yes	9	9
11	1x56	8x57	m4_off	33.8014	0	No	No	No	No	9	7
12	8x57	CT.Y472	m4_off	30.4465	0	No	No	No	No	7	5
13	2x46	3x42	m4_off	52.0257	7.29824	Yes	Yes	No	No	9	9
14	2x45	3x42	m4_off	51.1622	6.2715	No	No	No	No	9	9
15	2x45	4x46	m4_off	48.5377	2.11037	No	No	No	No	9	9
16	2x42	4x46	m4_off	47.6515	0	Yes	No	No	No	8	9
17	2x42	3x49	m4_off	20.6025	7.47975	Yes	No	Yes	Yes	8	9
18	3x32	7x42	m4_off	35.5426	4.31826	Yes	Yes	Yes	Yes	9	9
19	2x60	3x28	m4_off	59.8567	1.19741	Yes	Yes	Yes	Yes	8	7
20	2x60	7x38	m4_off	25.5485	7.68835	Yes	Yes	Yes	Yes	8	7
21	2x63	E1x50	m4_off	45.0101	1.09988	No	No	Yes	Yes	8	9
22	3x28	E2x50	m4_off	50.6526	0	Yes	Yes	Yes	No	7	9
23	2x63	E2x50	m4_off	52.3966	0	No	No	Yes	No	8	9
24	2x63	E2.Q184	m4_off	90.9544	3.48387	No	No	No	No	8	5
25	E2.P181	E2.Q184	m4_off	77.9933	1.1649	No	No	No	No	3	5
26	E2.P181	E2.V180	m4_off	71.5552	0	No	No	No	No	3	5
27	E2.R178	E2.V180	m4_off	58.594	9.73099	Yes	Yes	No	No	5	5
28	3x22	E2.R178	m4_off	13.0574	1.92886	No	No	Yes	Yes	4	5
29	3x26	E2.R178	m4_off	32.584	3.72497	No	No	Yes	Yes	8	5
30	4x57	Lig	m4_off	10.5744	5.05242	Yes	Yes	Yes	Yes	8	0
31	3x37	4x57	m4_off	12.0863	0.539105	No	Yes	Yes	Yes	9	8
32	3x37	4x53	m4_off	10.9029	5.15807	No	Yes	No	No	9	9
33	6x44	6x48	m4_off	23.4931	1.23534	Yes	Yes	Yes	Yes	9	9
34	5x47	5x51	m4_off	41.406	1.12968	Yes	Yes	Yes	No	9	8
35	5x51	6x45	m4_off	59.6104	0	Yes	No	No	No	8	8
36	6x41	6x45	m4_off	38.94	0	No	No	No	No	8	8
37	5x54	6x41	m4_off	21.1829	0	No	No	No	No	9	8
38	3x44	5x54	m4_off	15.1581	0	No	No	No	No	8	9
39	6x52	Lig	m4_off	22.3238	0	No	No	Yes	Yes	9	0
40	5x47	6x52	m4_off	21.8992	1.78799	Yes	Yes	No	No	9	9
41	5x51	6x44	m4_off	29.8887	1.9099	Yes	No	Yes	Yes	8	9
42	3x44	5x50	m4_off	12.1373	3.15607	No	No	No	No	8	9
43	2x42	3x46	m4_off	19.5889	0	Yes	No	No	No	8	9
44	3x46	6x37	m4_off	18.5329	0	No	No	No	No	9	9
45	3x50	6x37	m4_off	17.457	0	Yes	No	No	No	9	9
46	3x50	6x30	m4_off	11.0756	0	Yes	No	Yes	Yes	9	9
47	E2.L190	E2x52	m4_off	13.4283	2.19706	No	No	Yes	Yes	5	7
48	E2.F189	E2.L190	m4_off	11.2936	0	No	Yes	No	No	8	5
49	6x51	7x38	m4_off	12.4345	1.66879	Yes	Yes	Yes	Yes	9	7
50	6x51	7x34	m4_off	41.7117	0	Yes	Yes	Yes	No	9	6
51	6x58	7x34	m4_off	10.2432	1.81779	No	No	Yes	No	5	6
52	6x51	Lig	m4_off	20.7186	1.68233	Yes	Yes	Yes	Yes	9	0
53	7x34	E3.I430	m4_off	20.3137	8.72592	Yes	No	No	Yes	6	6
54	6x57	E3.I430	m4_off	18.8387	2.9556	No	No	No	Yes	7	6
55	6x57	6x60	m4_off	15.4639	0	No	No	No	No	7	6
56	5x58	6x41	m4_off	14.9769	4.56208	No	Yes	No	No	9	8
57	6x36	6x40	m4_off	10.5801	7.99176	No	No	No	Yes	9	9
58	6x45	6x49	m4_off	18.1733	1.63086	No	No	No	No	8	7
59	6x49	6x50	m4_off	15.1581	3.25901	No	No	No	No	7	9
60	6x50	7x40	m4_off	12.1373	1.63086	No	No	No	No	9	9
61	6x54	7x34	m4_off	10.1554	0	Yes	No	Yes	No	7	6
62	8x56	CT.Y472	m4_off	23.7196	0	Yes	No	No	No	6	5
63	3x26	4x62	m4_off	26.0921	2.83369	No	No	No	No	8	6
64	4x62	4x63	m4_off	13.0602	0	No	No	No	No	6	7
65	2x60	7x42	m4_off	36.9922	0	Yes	Yes	Yes	Yes	8	9
66	3x29	E2x52	m4_off	10.6084	3.21567	No	No	Yes	Yes	8	7
67	7x38	Lig	m4_off	38.8098	9.47363	Yes	Yes	Yes	Yes	7	0
68	3x32	7x38	m4_off	23.0656	0	Yes	Yes	Yes	Yes	9	7
69	6x48	7x41	m4_off	14.0058	1.64712	Yes	Yes	No	No	9	9
70	6x51	7x41	m4_off	13.8614	1.19199	Yes	Yes	No	No	9	9
71	2x53	7x46	Shared	56.063	25.7822	Yes	No	No	No	9	9
72	2x50	7x46	Shared	55.6977	25.8987	Yes	Yes	No	No	9	9
73	6x40	7x53	Shared	80.128	50.0312	No	Yes	No	Yes	9	9
74	2x43	7x53	Shared	75.6859	34.4946	No	No	No	Yes	8	9
75	2x40	2x43	Shared	74.1655	33.6927	Yes	Yes	No	No	9	8
76	1x57	2x40	Shared	14.9345	10.2809	No	No	Yes	Yes	9	9
77	6x48	Lig	Shared	100	64.1183	Yes	Yes	Yes	Yes	9	0
78	6x48	7x45	Shared	67.3084	66.8193	Yes	Yes	Yes	Yes	9	9
79	7x45	7x49	Shared	76.6626	75.3312	Yes	Yes	Yes	No	9	9
80	2x40	I1x50	Shared	26.5508	20.1067	Yes	Yes	Yes	Yes	9	9
81	1x56	8x53	Shared	18.4451	11.2101	No	No	No	Yes	9	9
82	1x56	8x54	Shared	18.7877	10.1969	No	No	Yes	Yes	9	9
83	2x46	2x50	Shared	26.4262	26.8767	Yes	Yes	Yes	Yes	9	9
84	3x28	E1x50	Shared	75.8557	30.6504	Yes	Yes	Yes	Yes	7	9
85	E1x50	E1x51	Shared	16.6303	21.5182	Yes	Yes	Yes	No	9	5
86	3x33	E2x52	Shared	21.6047	14.9432	Yes	Yes	Yes	Yes	9	7
87	3x33	Lig	Shared	17.9666	12.5999	Yes	Yes	Yes	Yes	9	0
88	5x47	6x48	Shared	24.5067	11.7601	Yes	Yes	Yes	Yes	9	9
89	3x49	I2x53	Shared	16.3869	10.1211	Yes	Yes	Yes	Yes	9	9
90	3x52	I2x53	Shared	13.383	32.4059	No	No	Yes	Yes	7	9
91	3x51	3x52	Shared	12.2986	33.8688	Yes	Yes	No	No	9	7
92	2x57	7x42	Shared	10.4612	17.1295	Yes	Yes	Yes	Yes	9	9
93	3x28	3x32	Shared	72.5885	32.6172	Yes	Yes	Yes	Yes	7	9
94	2x46	7x49	Shared	28.1532	73.8277	Yes	Yes	Yes	No	9	9
95	2x53	2x56	Shared	15.9905	25.7985	Yes	No	No	No	9	9
96	2x56	3x32	Shared	15.8942	16.5118	No	No	Yes	Yes	9	9
97	2x46	3x43	m4_on	0	100	Yes	Yes	No	No	9	9
98	3x43	7x53	m4_on	0	99.8347	No	No	No	Yes	9	9
99	1x60	I1x50	m4_on	3.47385	18.419	No	No	Yes	Yes	8	9
100	1x60	8x53	m4_on	0.0934288	16.4739	No	No	No	Yes	8	9
101	3x50	7x53	m4_on	0	41.4894	Yes	No	No	Yes	9	9
102	3x50	5x58	m4_on	0	41.2456	Yes	No	No	Yes	9	9
103	3x47	5x58	m4_on	0	59.2881	No	No	No	Yes	9	9
104	3x47	5x57	m4_on	0	56.5519	No	No	No	No	9	8
105	3x51	5x57	m4_on	2.28476	48.1998	Yes	Yes	No	No	9	8
106	I2x53	I2x57	m4_on	0.195351	17.8609	Yes	Yes	Yes	Yes	9	9
107	5x58	6x40	m4_on	0	43.2368	No	Yes	No	Yes	9	9
108	3x32	Lig	m4_on	0	23.4064	Yes	Yes	Yes	Yes	9	0
109	2x66	E1x51	m4_on	3.33513	16.2626	No	Yes	Yes	No	5	5
110	E2x51	Lig	m4_on	0	18.9527	No	No	Yes	Yes	4	0
111	E2.V180	E2x51	m4_on	6.53153	18.2564	No	No	No	No	5	4
112	3x51	3x55	m4_on	5.67368	10.9582	Yes	Yes	No	No	9	9
113	E2.F189	E2x52	m4_on	0	13.4343	No	Yes	Yes	Yes	8	7
114	5x47	5x48	m4_on	2.47162	10.8851	Yes	Yes	No	Yes	9	8
115	5x58	6x37	m4_on	0	19.657	No	Yes	No	No	9	9
116	5x62	6x37	m4_on	0	18.3079	No	No	No	No	8	9
117	5x62	6x34	m4_on	0	16.7881	No	No	No	No	8	9
118	6x30	6x34	m4_on	0	10.6439	Yes	Yes	No	No	9	9
119	7x34	Lig	m4_on	0	11.2264	Yes	No	Yes	Yes	6	0
120	1x32	2x66	m4_on	0	10.4841	No	No	No	Yes	6	5

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
2x53	2x56	Shared	7.74	6.19	1	0	2	2
2x53	7x42	m4_off	4.84	0	1	0	2	1
2x56	3x32	Shared	10.31	9.94	1	1	2	1
2x56	7x42	Shared	7.63	6.9975	1	1	2	1
2x57	7x39	Shared	8.14	4.3625	1	0	2	2
2x57	7x42	Shared	4.79	7.78	1	0	2	1
2x60	3x28	Shared	6.75	5.305	1	0	2	2
2x60	7x38	Shared	17.87	17.6225	1	0	2	1
2x60	7x39	m4_off	4.82	0	1	0	2	2
2x60	7x42	m4_off	5.96	0	1	0	2	1
3x28	3x32	Shared	13.4	4.1875	1	0	2	1
3x32	7x38	m4_off	5.75	0	1	1	1	1
3x32	7x42	Shared	6.9	10.915	1	1	1	1
3x33	4x57	Shared	14.47	13.8625	1	1	1	1
3x33	E2x52	Shared	10.88	5.6525	1	1	1	2
3x33	7x38	Shared	4.96	5.46	1	1	1	1
3x33	Lig	Shared	20.21	8.63	1	1	1	0
3x36	6x48	m4_off	4.94	0	1	0	1	1
3x36	Lig	Shared	7.67	6.8575	1	0	1	0
3x37	4x53	Shared	8.94	5.5875	0	1	1	2
3x37	4x57	Shared	10.17	8.475	0	1	1	1
4x57	4x61	m4_off	4.7	0	1	1	1	2
4x57	Lig	Shared	8.73	11.645	1	1	1	0
4x61	E2x52	Shared	4.42	2.945	0	0	2	2
E2.V180	E2x51	Shared	11.8	10.4875	0	0	2	1
5x461	Lig	Shared	5.03	3.0025	0	0	1	0
5x47	5x48	Shared	8.25	9.03	1	1	2	2
5x47	6x44	Shared	4.29	4.825	1	1	2	2
5x47	6x48	Shared	6.01	6.015	1	1	2	1
5x47	6x52	Shared	24.17	17.2175	1	1	2	1
6x44	6x48	Shared	19.04	7.515	1	1	2	1
6x44	7x45	Shared	4.83	4.2275	1	1	2	2
6x47	6x48	m4_off	4.85	0	1	0	2	1
6x47	7x45	Shared	7.31	9.87	1	0	2	2
6x48	7x41	Shared	11.75	8.1625	1	1	1	1
6x48	7x45	Shared	4.52	9.04	1	1	1	2
6x48	Lig	Shared	13.09	8.99	1	1	1	0
6x51	6x55	Shared	3.79	6.625	1	1	1	2
6x51	7x34	m4_off	6.75	0	1	1	1	1
6x51	7x38	Shared	8.94	6.455	1	1	1	1
6x51	7x41	Shared	4.03	4.03	1	1	1	1
6x51	Lig	Shared	12.73	11.2	1	1	1	0
6x52	Lig	m4_off	11.4	0	0	1	1	0
6x54	E3.I430	Shared	7.29	4.0075	1	0	2	2
6x54	7x34	m4_off	5.82	0	1	0	2	1
6x58	7x34	Shared	7.91	4.8025	0	0	2	1
7x34	E3.I430	Shared	17.62	8.515	1	0	1	2
7x38	7x42	Shared	8.94	6.7	1	1	1	1
7x38	Lig	Shared	17.97	7.9225	1	1	1	0
7x39	7x42	m4_off	6.75	0	1	0	2	1
7x41	Lig	Shared	7.09	4.9125	1	1	1	0
7x42	Lig	m4_off	5.99	0	1	1	1	0
3x41	4x53	m4_off	3.07	0	0	0	2	2
5x44	Lig	m4_off	3.02	0	0	0	1	0
6x61	E3.S428	m4_off	1.72	0	0	0	2	1
3x32	Lig	m4_on	0	4.765	1	1	1	0
3x33	6x51	m4_on	0	6.4525	1	1	1	1
3x37	3x41	m4_on	0	5.6075	0	1	1	2
3x37	Lig	m4_on	0	3.9725	0	1	1	0
3x40	6x44	m4_on	0	4.5875	0	1	2	2
3x40	6x48	m4_on	0	4.29	0	1	2	1
4x56	4x57	m4_on	0	5.9775	0	0	2	1
4x57	5x43	m4_on	0	8.185	1	1	1	2
6x48	6x52	m4_on	0	3.6725	1	1	1	1
6x51	6x52	m4_on	0	5.2325	1	1	1	1
E2x51	Lig	m4_on	0	7.925	0	0	1	0
7x34	Lig	m4_on	0	4.875	1	0	1	0
7x31	Lig	m4_on	0	2.5575	0	0	1	0
5x44	5x48	m4_on	0	2.0025	0	0	1	2
E3.S428	Lig	m4_on	0	0.7725	0	0	1	0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	m4_off	5DSG-M₄-Tiotropium
	m4_on	7TRS-M₄-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M₄-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M₄-PubChem 9864275-Gi1/&β;1/&γ;2

Network Difference
Value	m4_off	m4_on
I_min	3.79	3.58
Number of Linked Nodes	270	277
Number of Specific Nodes	8 (2.96%)	15 (5.42%)
Number of Shared Nodes	262 (97.04%)	262 (94.58%)
Number of Links	305	306
Number of Specific Links	115 (37.70%)	116 (37.91%)
Number of Shared Links	190 (62.30%)	190 (62.09%)
Number of Hubs	42	42
Number of Specific Hubs	12 (28.57%)	12 (28.57%)
Number of Shared Hubs	30 (71.43%)	30 (71.43%)
Average % Shared Neighbours (Jaccard)	47.60
Average % Shared Neighbours (Otsuka)	55.57
Average % Shared Neighbours (Overlap Coefficient)	63.50
Average % Shared Cliques (k3-6)	58.54
Graphlets Similarity	0.6552

Paths Difference
Value	m4_off	m4_on
Number Of Nodes in MetaPath	85	50
Specific Nodes in MetaPath	47 (55.29%)	12 (24.00%)
Shared Nodes in MetaPath	262 (97.04%)	262 (97.04%)
Number Of Links MetaPath	96	50
Specific Links in MetaPath	70 (72.92%)	24 (48.00%)
Shared Links in MetaPath	190 (62.30%)	190 (62.30%)
Number of Shortest Paths	93945	63257
Length Of Smallest Path	3	3
Average Path Length	14.8862	13.963
Length of Longest Path	30	29
Minimum Path Strength	1.185	0.38625
Average Path Strength	7.5625	6.2759
Maximum Path Strength	18.5933	15.1962
Minimum Path Correlation	0.7	0.7
Average Path Correlation	0.932059	0.915009
Maximum Path Correlation	0.99	0.99
Minimum % Of Corr. Nodes	4.16667	3.7037
Average % Of Corr. Nodes	47.7524	41.0635
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	50.2432	49.0896
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download m4_off_on.zip<

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