Orange: nodes, hubs and links specific of mglu2_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of mglu2_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.


Index Hub Owner mglu2_off Avg Int. Strength mglu2_on Avg Int. Strength mglu2_off Num Of Links mglu2_on Num Of Links ConSurf
1R1.1x53 mglu2_off4.162.8526
2R1.1x57 mglu2_off9.831433.48729
3R1.2x47 mglu2_off4.523.62333539
4R1.2x49 mglu2_off1.9052.58333438
5R1.2x50 mglu2_off7.62.915438
6R1.3x30 mglu2_off2.65752.235414
7R1.3x37 mglu2_off4.83755.9225428
8R1.3x44 mglu2_off6.59753.195429
9R1.3x46 mglu2_off6.78754.23419
10R1.3x49 mglu2_off9.748.515428
11R1.E2x52 mglu2_off16.2856.42833435
12R1.5x40 mglu2_off11.362512.33417
13R1.5x47 mglu2_off5.6386.78167537
14R1.6x40 mglu2_off4.844.485429
15R1.7x30 mglu2_off5.322.60833438
16R1.7x50 mglu2_off5.64.12333438
17R1.7x521 mglu2_off4.77253.18428
18R1.7x56 mglu2_off9.2964.315539
19R1.7x60 mglu2_off5.562.65519
20R2.1x57 mglu2_off8.6054.575429
21R2.2x44 mglu2_off6.53252.4325428
22R2.2x58 mglu2_off4.065.55417
23R2.2x60 mglu2_off6.82758.93167438
24R2.3x43 mglu2_off4.1143.535518
25R2.3x47 mglu2_off5.2953.59429
26R2.3x49 mglu2_off4.4156.51333438
27R2.I2 mglu2_off5.8163.445526
28R2.E2x52 mglu2_off11.644.4825425
29R2.5x54 mglu2_off5.64754.86833439
30R2.5x61 mglu2_off2.821.17428
31R2.6x40 mglu2_off5.76755.3625429
32R2.6x43 mglu2_off5.9556.5475428
33R2.6x47 mglu2_off6.281.77667438
34R2.6x51 mglu2_off8.04756.96167439
35R2.6x52 mglu2_off7.79752.04427
36R2.6x58 mglu2_off3.12751.935427
37R2.7x38 mglu2_off7.0944.0425529
38R2.7x521 mglu2_off5.0553.56428
39R1.NT Shared737.273700.8939125
40R1.1x50 Shared5.01753.1575447
41R1.I1x47 Shared4.80253.901459
42R1.2x40 Shared6.8856.76125449
43R1.2x42 Shared4.38253.965448
44R1.2x54 Shared7.263.60429478
45R1.2x60 Shared8.264.019458
46R1.E1 Shared6.167.637556
47R1.3x40 Shared6.21757.121456
48R1.4x53 Shared12.466.176459
49R1.4x60 Shared8.36753.74125447
50R1.E2 Shared20.32120.229110116
51R1.I3 Shared4.944.64125648
52R1.6x41 Shared5.43753.2925449
53R1.6x48 Shared5.44256.2775469
54R1.7x32 Shared5.8166.045555
55R1.7x53 Shared5.934.245859
56R2.NT Shared647.475654.71310135
57R2.1x50 Shared3.6523.099557
58R2.2x40 Shared8.54255.50125449
59R2.2x47 Shared4.7544.48625549
60R2.2x54 Shared4.05254.35583468
61R2.E1 Shared8.18255.751456
62R2.3x29 Shared7.317.295568
63R2.3x36 Shared8.64756.503458
64R2.4x53 Shared9.935.69449
65R2.4x60 Shared6.6628.57375547
66R2.E2 Shared14.902521.42158136
67R2.I3 Shared6.932864.9075768
68R2.6x41 Shared5.6464.413559
69R2.6x48 Shared10.48755.34469
70R2.7x32 Shared11.6666.4875545
71R2.7x53 Shared7.5983.962559
72R1.2x44 mglu2_on1.174.4275148
73R1.2x46 mglu2_on5.256673.435348
74R1.2x51 mglu2_on8.383.39125145
75R1.2x57 mglu2_on3.864.335347
76R1.3x28 mglu2_on5.2854.68375248
77R1.3x32 mglu2_on5.123.52125248
78R1.3x36 mglu2_on7.786.10667268
79R1.I2 mglu2_on010.6743070
80R1.E2x51 mglu2_on5.097.54875146
81R1.5x46 mglu2_on17.115.262258
82R1.5x61 mglu2_on1.682.67625148
83R1.6x33 mglu2_on8.795.305249
84R1.6x51 mglu2_on4.473.022259
85R1.6x55 mglu2_on6.953339.03625348
86R1.6x57 mglu2_on02.56375048
87R1.7x33 mglu2_on7.642.785355
88R2.1x35 mglu2_on9.94.3425345
89R2.3x40 mglu2_on8.446676.4175366
90R2.3x46 mglu2_on8.585.22625249
91R2.4x46 mglu2_on2.763332.332357
92R2.5x46 mglu2_on16.03673.20167368
93R2.5x47 mglu2_on8.9054.4625247
94R2.6x55 mglu2_on9.0757.69875248
95R2.7x63 mglu2_on02.01125040
96R1.Allo1 mglu2_on07.761540130
   
Orange: nodes, hubs and links specific of mglu2_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of mglu2_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Owner mglu2_off Recurrence mglu2_on Recurrence mglu2_off Hub1? mglu2_on Hub1? mglu2_off Hub2? mglu2_on Hub2? ConSurf1 ConSurf2
1R1.7x49 R1.7x521 mglu2_off20.4310NoNoYesNo78
2R1.6x40 R1.7x49 mglu2_off20.91860YesNoNoNo97
3R1.6x40 R1.6x43 mglu2_off39.53970YesNoNoNo98
4R1.7x44 R1.7x48 mglu2_off40.940NoNoNoNo67
5R1.6x47 R1.7x44 mglu2_off41.40580NoNoNoNo86
6R1.6x47 R1.7x45 mglu2_off41.8710NoNoNoNo89
7R1.7x45 R1.7x46 mglu2_off42.33580NoNoNoNo98
8R1.2x53 R1.7x46 mglu2_off42.80NoNoNoNo68
9R1.2x53 R1.3x39 mglu2_off43.7273.39633NoNoNoNo66
10R1.2x49 R1.3x39 mglu2_off44.18974.52158YesNoNoNo86
11R1.2x49 R1.3x38 mglu2_off45.57476.76087YesNoNoNo87
12R1.3x37 R1.3x38 mglu2_off47.41440YesNoNoNo87
13R1.3x34 R1.3x37 mglu2_off54.46470NoNoYesNo68
14R1.3x30 R1.3x34 mglu2_off54.87450YesNoNoNo46
15R1.3x30 R1.4x61 mglu2_off56.67340YesNoNoNo46
16R1.3x26 R1.4x61 mglu2_off57.11760NoNoNoNo56
17R1.3x26 R1.E2 mglu2_off57.56320.990673NoNoYesYes56
18R1.7x521 R1.7x53 mglu2_off15.96230YesNoYesYes89
19R1.3x46 R1.6x33 mglu2_off10.0730YesNoNoYes99
20R1.6x33 R1.6x37 mglu2_off10.57140NoYesNoNo99
21R1.6x37 R1.6x38 mglu2_off14.04541.0131NoNoNoNo99
22R1.5x58 R1.6x38 mglu2_off14.53960NoNoNoNo99
23R1.5x58 R1.6x41 mglu2_off15.03340NoNoYesYes99
24R1.6x40 R1.6x41 mglu2_off16.51150YesNoYesYes99
25R1.2x60 R1.7x39 mglu2_off10.0710YesYesNoNo87
26R1.2x61 R1.7x39 mglu2_off10.50950.94955NoNoNoNo77
27R1.2x61 R1.7x32 mglu2_off10.94960NoNoYesYes75
28R1.5x47 R1.5x50 mglu2_off10.6080YesNoNoNo79
29R2.3x25 R2.E2 mglu2_off39.73730.990673NoNoYesYes96
30R2.3x25 R2.E2x52 mglu2_off39.85990NoNoYesNo95
31R2.3x29 R2.E2x52 mglu2_off40.00752.00564YesYesYesNo85
32R2.3x29 R2.5x39 mglu2_off60.43950YesYesNoNo86
33R2.4x60 R2.5x39 mglu2_off1000.994411YesYesNoNo76
34R2.4x57 R2.4x60 mglu2_off49.75010NoNoYesYes67
35R2.4x53 R2.4x57 mglu2_off49.26570YesYesNoNo96
36R2.4x53 R2.5x46 mglu2_off97.42832.95893YesYesNoYes98
37R2.3x44 R2.5x50 mglu2_off94.77260NoNoNoNo99
38R2.3x43 R2.5x54 mglu2_off72.66370YesNoYesNo89
39R2.3x43 R2.6x40 mglu2_off31.31850YesNoYesNo89
40R2.6x40 R2.7x52 mglu2_off32.03281.41872YesNoNoNo96
41R2.6x43 R2.7x52 mglu2_off30.8370YesNoNoNo86
42R2.6x43 R2.6x47 mglu2_off29.04740YesNoYesNo88
43R2.6x47 R2.6x51 mglu2_off27.28920YesNoYesNo89
44R2.6x51 R2.7x41 mglu2_off24.30790.968242YesNoNoNo99
45R2.7x38 R2.7x41 mglu2_off12.15890YesNoNoNo99
46R2.E2 R2.E2x50 mglu2_off39.73730.990673YesYesNoNo69
47R2.E2x50 R2.E2x52 mglu2_off39.85990NoNoYesNo95
48R2.3x26 R2.E2 mglu2_off20.37830NoNoYesYes56
49R2.3x26 R2.4x61 mglu2_off20.61871.00376NoNoNoNo56
50R2.3x29 R2.4x61 mglu2_off20.68480YesYesNoNo86
51R2.4x64 R2.E2x52 mglu2_off39.77880NoNoYesNo65
52R2.4x64 R2.5x39 mglu2_off39.75561.98321NoNoNoNo66
53R2.4x60 R2.5x43 mglu2_off49.46420YesYesNoNo77
54R2.4x53 R2.5x43 mglu2_off49.2220YesYesNoNo97
55R2.3x43 R2.7x521 mglu2_off35.62360YesNoYesNo88
56R2.2x46 R2.7x521 mglu2_off35.57420NoNoYesNo88
57R2.2x46 R2.7x53 mglu2_off34.39752.1963NoNoYesYes89
58R2.3x47 R2.3x50 mglu2_off16.95720YesNoNoNo99
59R2.3x50 R2.I3 mglu2_off13.35982.01312NoNoYesYes98
60R2.2x47 R2.2x48 mglu2_off15.48490YesYesNoNo94
61R2.2x48 R2.2x49 mglu2_off14.87161.03927NoNoNoNo48
62R2.2x49 R2.3x38 mglu2_off13.64356.1889NoNoNoNo87
63R2.3x38 R2.4x50 mglu2_off10.56427.20761NoNoNoNo77
64R2.7x41 R2.7x42 mglu2_off11.5510NoNoNoNo98
65R2.3x36 R2.7x42 mglu2_off10.99081.11217YesYesNoNo88
66R1.6x43 R1.7x48 Shared40.473866.6255NoNoNoNo87
67R1.E2 R1.NT Shared69.696737.625YesYesYesYes65
68R1.7x32 R1.NT Shared14.654312.1292YesYesYesYes55
69R1.NT R2.NT Shared90.550255.4422YesYesYesYes55
70R2.E2 R2.NT Shared98.240742.3765YesYesYesYes65
71R2.5x46 R2.5x50 Shared95.836410.0264NoYesNoNo89
72R2.3x44 R2.5x54 Shared92.547314.2563NoNoYesNo99
73R2.2x47 R2.7x53 Shared26.218522.2939YesYesYesYes99
74R2.3x47 R2.5x54 Shared17.444816.7854YesNoYesNo99
75R1.1x35 R1.7x32 mglu2_on012.9965NoNoYesYes55
76R1.1x35 R1.7x33 mglu2_on011.0058NoNoNoYes55
77R1.7x30 R1.7x33 mglu2_on3.0766811.0301YesNoNoYes85
78R1.7x30 R1.7x32 mglu2_on2.6518712.9965YesNoYesYes85
79R1.1x43 R1.2x57 mglu2_on0.0012718843.8999NoNoNoYes77
80R1.1x43 R1.2x58 mglu2_on044.4027NoNoNoNo77
81R1.1x40 R1.2x58 mglu2_on045.984NoNoNoNo57
82R1.1x40 R1.NT mglu2_on046.5224NoNoYesYes55
83R1.2x57 R1.7x43 mglu2_on0.0012718840.012NoYesNoNo78
84R1.2x54 R1.7x43 mglu2_on039.0288YesYesNoNo88
85R1.2x50 R1.2x54 mglu2_on2.031736.3614YesNoYesYes88
86R1.2x54 R1.7x50 mglu2_on067.6293YesYesYesNo88
87R1.1x56 R1.7x56 mglu2_on015.3965NoNoYesNo69
88R1.1x57 R1.7x56 mglu2_on0.031542638.4624YesNoYesNo99
89R1.1x53 R1.1x57 mglu2_on0.0022893839.7895YesNoYesNo69
90R1.1x53 R1.2x47 mglu2_on0.040700141.1129YesNoYesNo69
91R1.2x47 R1.7x53 mglu2_on3.0372589.8092YesNoYesYes99
92R1.7x50 R1.7x53 mglu2_on1.55347100YesNoYesYes89
93R1.1x54 R1.2x47 mglu2_on2.066351.7785NoNoYesNo59
94R1.1x54 R1.2x44 mglu2_on0.51714650.4851NoNoNoYes58
95R1.1x56 R1.1x59 mglu2_on012.604NoNoNoNo64
96R1.1x59 R1.1x60 mglu2_on1.0279311.2021NoNoNoNo44
97R1.2x40 R1.2x44 mglu2_on045.2121YesYesNoYes98
98R1.6x31 R1.6x33 mglu2_on014.0545NoNoNoYes99
99R1.6x33 R1.7x56 mglu2_on022.3836NoYesYesNo99
100R1.2x40 R1.2x41 mglu2_on042.6457YesYesNoNo96
101R1.2x41 R1.4x39 mglu2_on038.6755NoNoNoNo66
102R1.4x42 R1.4x45 mglu2_on015.5423NoNoNoNo87
103R1.4x45 R1.I2 mglu2_on016.933NoNoNoYes70
104R1.4x41 R1.I2 mglu2_on033.3296NoNoNoYes70
105R1.4x38 R1.4x41 mglu2_on0.50824334.6717NoNoNoNo77
106R1.4x38 R1.4x39 mglu2_on1.5237137.3446NoNoNoNo76
107R1.2x46 R1.3x43 mglu2_on065.9994NoYesNoNo88
108R1.3x43 R1.6x41 mglu2_on066.5115NoNoYesYes89
109R1.5x51 R1.6x41 mglu2_on067.7919NoNoYesYes89
110R1.3x40 R1.5x51 mglu2_on5.7949468.6218YesYesNoNo68
111R1.3x40 R1.Allo1 mglu2_on013.8619YesYesNoYes60
112R1.Allo1 R1.E2 mglu2_on054.7749NoYesYesYes06
113R1.3x41 R1.4x49 mglu2_on011.7871NoNoNoNo95
114R1.4x49 R1.5x46 mglu2_on012.1778NoNoNoYes58
115R1.4x53 R1.5x46 mglu2_on0.5074812.3012YesYesNoYes98
116R1.4x53 R1.5x43 mglu2_on020.0471YesYesNoNo97
117R1.5x43 R1.Allo1 mglu2_on021.2471NoNoNoYes70
118R1.2x46 R1.7x49 mglu2_on071.4051NoYesNoNo87
119R1.2x50 R1.7x49 mglu2_on071.2144YesNoNoNo87
120R1.2x56 R1.2x60 mglu2_on2.5613110.4282NoNoYesYes78
121R1.2x60 R1.Allo1 mglu2_on012.4395YesYesNoYes80
122R1.E2 R1.E2x51 mglu2_on0.50824313.5535YesYesNoYes66
123R1.6x48 R1.Allo1 mglu2_on042.0718YesYesNoYes90
124R1.3x52 R1.I2 mglu2_on011.3329NoNoNoYes70
125R1.3x50 R1.6x34 mglu2_on011.2731NoNoNoNo99
126R1.6x31 R1.6x34 mglu2_on012.675NoNoNoNo99
127R2.6x35 R2.6x36 mglu2_on010.7236NoNoNoNo95
128R2.6x35 R2.6x39 mglu2_on064.3096NoNoNoNo99
129R1.6x39 R2.6x39 mglu2_on065.4386NoNoNoNo99
130R1.6x39 R1.6x43 mglu2_on0.50824366.0237NoNoNoNo98
131R1.6x44 R1.7x48 mglu2_on063.5264NoNoNoNo87
132R1.6x44 R1.6x48 mglu2_on063.9021NoNoYesYes89
133R1.6x42 R2.6x46 mglu2_on011.2582NoNoNoNo98
134R1.6x47 R2.6x46 mglu2_on046.128NoNoNoNo88
135R1.6x47 R1.6x51 mglu2_on045.7523NoNoNoYes89
136R1.6x48 R1.6x51 mglu2_on032.2922YesYesNoYes99
137R1.6x51 R1.6x55 mglu2_on015.6732NoYesNoYes98
138R1.6x55 R1.Allo1 mglu2_on013.7591NoYesNoYes80
139R1.6x57 R2.6x54 mglu2_on010.0712NoYesNoNo87
140R1.6x57 R1.6x58 mglu2_on016.0358NoYesNoNo87
141R1.6x58 R1.7x33 mglu2_on0.00050875218.0433NoNoNoYes75
142R2.7x32 R2.NT mglu2_on5.0669114.3386YesYesYesYes55
143R2.1x35 R2.7x32 mglu2_on3.552116.8583NoYesYesYes55
144R2.1x35 R2.7x36 mglu2_on3.0476812.1479NoYesNoNo57
145R2.6x32 R2.6x35 mglu2_on0.62856358.6796NoNoNoNo99
146R2.6x32 R2.I3 mglu2_on1.8854358.1899NoNoYesYes98
147R2.6x33 R2.I3 mglu2_on0.56776746.1896NoNoYesYes98
148R2.6x33 R2.6x37 mglu2_on6.1197832.9483NoNoNoNo99
149R2.6x37 R2.7x521 mglu2_on030.408NoNoYesNo98
150R2.7x521 R2.7x53 mglu2_on029.4118YesNoYesYes89
151R2.1x50 R2.2x47 mglu2_on9.9468617.1648YesYesYesYes79
152R2.I1x51 R2.I3 mglu2_on016.7442NoNoYesYes78
153R2.I1 R2.I1x51 mglu2_on010.9572NoNoNoNo57
154R2.3x46 R2.6x33 mglu2_on022.864NoYesNoNo99
155R2.2x42 R2.3x46 mglu2_on1.8747517.0676NoNoNoYes89
156R2.2x42 R2.3x45 mglu2_on7.4722916.09NoNoNoNo87
157R2.3x45 R2.4x46 mglu2_on8.091715.2227NoNoNoYes77
158R2.3x41 R2.4x46 mglu2_on011.2451NoNoNoYes97
159R2.5x37 R2.E2 mglu2_on039.5297NoNoYesYes46
160R2.5x37 R2.6x55 mglu2_on036.5558NoNoNoYes48
161R2.6x55 R2.7x38 mglu2_on2.4661736.0231NoYesYesNo89
162R2.2x60 R2.7x38 mglu2_on4.88335.7259YesNoYesNo89
163R2.2x56 R2.2x60 mglu2_on2.4692334.4362NoNoYesNo78
164R2.2x56 R2.3x32 mglu2_on032.0642NoNoNoNo78
165R2.3x32 R2.3x36 mglu2_on0.64255432.0399NoNoYesYes88
166R2.3x36 R2.3x40 mglu2_on021.8621YesYesNoYes86
167R1.6x50 R2.6x46 mglu2_on036.8755NoNoNoNo78
168R1.6x50 R2.6x47 mglu2_on035.9726NoNoYesNo78
169R2.6x47 R2.7x45 mglu2_on1.2344934.4025YesNoNoNo89
170R2.6x48 R2.7x45 mglu2_on033.81YesYesNoNo99
171R2.3x40 R2.5x50 mglu2_on011.4395NoYesNoNo69
172R2.3x40 R2.5x51 mglu2_on2.4641439.7895NoYesNoNo68
173R2.5x51 R2.6x41 mglu2_on038.7746NoNoYesYes89
174R2.5x54 R2.6x41 mglu2_on2.3003228.4566YesNoYesYes99
175R2.3x44 R2.3x48 mglu2_on012.8395NoNoNoNo96
176R2.3x47 R2.6x37 mglu2_on017.2471YesNoNoNo99
177R2.3x48 R2.5x57 mglu2_on011.4189NoNoNoNo67
178R1.7x32 R1.E2 mglu2_on014.7367YesYesYesYes56
179R2.3x40 R2.6x48 mglu2_on027.4921NoYesYesYes69
180R1.3x40 R1.6x48 mglu2_on053.9618YesYesYesYes69
181R1.1x50 R1.2x50 mglu2_on0.50213834.9577YesYesYesNo78
182R1.1x50 R1.7x50 mglu2_on0.52401433.509YesYesYesNo78

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Midway



Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Node1Node2OwnerNet1LinkStrengthNet2LinkStrengthComm1Comm2Node1ShellNode2Shell
R1.NTR1.NTShared3180.94040.751122
R1.NTR2.NTShared81.71154.891121
R2.NTR2.NTShared3130.474088.881111
R2.LigR2.NTShared66.7873.9450001
R2.E2R2.NTShared39.7460.431121
R2.7x31R2.NTShared5.968.7851121
R2.7x32R2.NTShared13.789.911121
R2.7x35R2.NTShared3.042.280021
R2.1x33R2.7x32Shared9.532.381122
R2.E1R2.E1Shared6.695.021122
R2.E1R2.E2Shared11.76.9251122
R2.E2R2.E2Shared22.3774.4951122
R2.7x31R2.7x32Shared16.465.661122
R2.1x32R2.NTShared1.51.7650021
R2.2x62R2.NTShared1.32.5951021
R2.E1R2.NTmglu2_on07.9651121
R2.2x61R2.NTmglu2_on05.580121
R2.1x33R2.NTmglu2_on05.361121
R2.7x31R2.E2mglu2_on011.0251122

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

2D representation of the interactions of this orthosteric/allosteric ligand.


Node1Node2OwnerNet1LinkStrengthNet2LinkStrengthComm1Comm2Node1ShellNode2Shell
R1.NTR1.NTShared3180.94040.751111
R1.LigR1.NTShared66.469.2150001
R1.NTR2.NTShared81.71154.891112
R1.E2R1.NTShared77.3159.131121
R1.7x31R1.NTShared20.553.3651121
R1.E1R1.NTShared13.5315.31121
R1.1x33R1.NTShared5.392.4851121
R1.7x32R1.NTShared8.7715.591121
R1.E1R1.E1Shared3.354.1851122
R1.E1R1.E2Shared7.518.031122
R1.E2R1.E2Shared37.4459.8751122
R1.7x32R1.7x35mglu2_off7.7601122
R2.NTR2.NTShared3130.474088.881122
R1.1x32R1.NTmglu2_on02.470121
R1.1x40R1.NTmglu2_on04.9050121
R1.7x31R1.E2mglu2_on08.51122
R1.7x31R1.7x32mglu2_on03.0851122
R1.7x32R1.E2mglu2_on03.881122
R1.7x35R1.NTmglu2_on01.8750021

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
Id Description
mglu2_off 7MTQ-mGlu2; mGlu2-LY341495
mglu2_on 7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
Network Difference
Value mglu2_off mglu2_on
Imin 2.44 2.295
Number of Linked Nodes 399 447
Number of Specific Nodes 5 (1.25%) 53  (11.86%)
Number of Shared Nodes 394 (98.75%) 394  (88.14%)
Number of Links 461 513
Number of Specific Links 230 (49.89%) 282  (54.97%)
Number of Shared Links 231 (50.11%) 231  (45.03%)
Number of Hubs 71 58
Number of Specific Hubs 38 (53.52%) 25  (43.10%)
Number of Shared Hubs 33 (46.48%) 33  (56.90%)
Average % Shared Neighbours (Jaccard) 34.24
Average % Shared Neighbours (Otsuka) 43.69
Average % Shared Neighbours (Overlap Coefficient) 53.20
Average % Shared Cliques (k3-6) 51.60
Graphlets Similarity 0.747692
Paths Difference
Value mglu2_off mglu2_on
Number Of Nodes in MetaPath 72 110
Specific Nodes in MetaPath 47 (65.28%) 85  (77.27%)
Shared Nodes in MetaPath 394 (98.75%) 394  (98.75%)
Number Of Links MetaPath 74 117
Specific Links in MetaPath 65 (87.84%) 108  (92.31%)
Shared Links in MetaPath 231 (50.11%) 231  (50.11%)
Number of Shortest Paths 440713 145240
Length Of Smallest Path 3 3
Average Path Length 30.8836 18.4947
Length of Longest Path 58 47
Minimum Path Strength 1.175 0.77
Average Path Strength 11.3145 8.21633
Maximum Path Strength 59.745 85.24
Minimum Path Correlation 0.73 0.72
Average Path Correlation 0.988451 0.982236
Maximum Path Correlation 1 1
Minimum % Of Corr. Nodes 14.2857 3.84615
Average % Of Corr. Nodes 70.561 77.6076
Maximum % Of Corr. Nodes 100 100
Minimum Path Hubs % 0 0
Average Path Hubs % 46.4762 37.4222
Maximum Path Hubs % 100 100

Details about the values in these tables can be found in the corresponding documentation page .

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download mglu2_off_on.zip<



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