Orange: nodes, hubs and links specific of mglu_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of mglu_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.


Index Hub Owner mglu_off Avg Int. Strength mglu_on Avg Int. Strength mglu_off Num Of Links mglu_on Num Of Links ConSurf
1R1.1x60 mglu_off00434
2R1.2x47 mglu_off500439
3R1.2x56 mglu_off33.33330437
4R1.2x60 mglu_off5025628
5R1.3x44 mglu_off33.33330439
6R1.3x46 mglu_off33.33330429
7R1.4x42 mglu_off00428
8R1.5x40 mglu_off33.33330417
9R1.5x57 mglu_off025537
10R1.5x60 mglu_off00427
11R1.6x55 mglu_off66.666725638
12R1.E3 mglu_off33.33330428
13R2.I1x47 mglu_off33.33330529
14R2.2x44 mglu_off33.33330418
15R2.2x52 mglu_off00425
16R2.2x56 mglu_off33.33330417
17R2.2x58 mglu_off33.33330437
18R2.3x44 mglu_off00439
19R2.4x53 mglu_off66.666725629
20R2.4x60 mglu_off33.333325427
21R2.6x55 mglu_off66.66670538
22R2.6x58 mglu_off00417
23R2.E3 mglu_off33.33330428
24R2.7x42 mglu_off00418
25R1.NT Shared10010011135
26R1.1x57 Shared66.666725459
27R1.I1x47 Shared33.333375459
28R1.2x40 Shared83.333325649
29R1.2x50 Shared66.666750448
30R1.2x54 Shared100100788
31R1.E1 Shared10050556
32R1.3x29 Shared66.66670648
33R1.3x36 Shared16.666750448
34R1.3x40 Shared33.3333100466
35R1.4x53 Shared66.666725559
36R1.E2 Shared10010011146
37R1.E2x52 Shared33.33330445
38R1.5x46 Shared33.333350648
39R1.I3 Shared10010010118
40R1.6x41 Shared33.333350449
41R1.6x42 Shared025459
42R1.6x48 Shared66.666750769
43R1.7x32 Shared33.333325545
44R1.7x50 Shared025548
45R1.7x53 Shared83.333375989
46R2.NT Shared10010010135
47R2.1x35 Shared16.66670445
48R2.1x57 Shared66.666750449
49R2.2x40 Shared83.33330549
50R2.2x47 Shared500549
51R2.2x54 Shared100100768
52R2.2x60 Shared500548
53R2.E1 Shared100100546
54R2.3x29 Shared10025648
55R2.3x36 Shared5050448
56R2.3x40 Shared33.333350566
57R2.E2 Shared1001009146
58R2.E2x52 Shared33.33330445
59R2.5x46 Shared33.333325648
60R2.5x57 Shared00447
61R2.I3 Shared1001001198
62R2.6x40 Shared33.333350449
63R2.6x41 Shared66.666775559
64R2.6x48 Shared100100689
65R2.6x51 Shared050459
66R2.7x32 Shared33.333325655
67R2.7x53 Shared83.333375889
68R1.1x35 mglu_on16.66670345
69R1.3x45 mglu_on025347
70R1.3x52 mglu_on050147
71R1.3x56 mglu_on00047
72R1.I2 mglu_on0100060
73R1.4x57 mglu_on00146
74R1.4x64 mglu_on00246
75R1.6x37 mglu_on025149
76R1.6x51 mglu_on050359
77R1.6x54 mglu_on00147
78R2.I1 mglu_on00245
79R2.2x50 mglu_on33.333350348
80R2.3x28 mglu_on050148
81R2.3x45 mglu_on025347
82R2.I2 mglu_on33.333350366
83R2.5x39 mglu_on00246
84R2.5x51 mglu_on00248
85R2.6x35 mglu_on00149
86R2.6x54 mglu_on00147
87R1.Allo1 mglu_on050090
   
Orange: nodes, hubs and links specific of mglu_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of mglu_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Owner mglu_off Recurrence mglu_on Recurrence mglu_off Hub1? mglu_on Hub1? mglu_off Hub2? mglu_on Hub2? ConSurf1 ConSurf2
1R1.7x32 R1.NT mglu_off88.08644.22232YesYesYesYes55
2R1.2x60 R1.7x35 mglu_off82.28840YesNoNoNo87
3R1.7x32 R1.7x35 mglu_off82.55270YesYesNoNo57
4R1.2x53 R1.7x42 mglu_off48.85690.649514NoNoNoNo68
5R1.2x53 R1.3x35 mglu_off49.27511.29806NoNoNoNo66
6R1.3x35 R1.3x36 mglu_off49.69160NoNoYesYes68
7R1.3x36 R1.6x48 mglu_off61.18080.0289531YesYesYesYes89
8R1.6x48 R1.6x52 mglu_off71.1650YesYesNoNo97
9R1.5x44 R1.6x52 mglu_off71.83070NoNoNoNo87
10R1.3x32 R1.5x44 mglu_off72.16090NoNoNoNo88
11R1.2x60 R1.3x32 mglu_off72.48930YesNoNoNo88
12R1.2x50 R1.7x42 mglu_off44.37870YesYesNoNo88
13R1.2x50 R1.7x50 mglu_off43.98360.742163YesYesYesYes88
14R1.7x53 R1.7x56 mglu_off29.57630YesYesNoNo99
15R1.1x60 R1.7x56 mglu_off29.18380YesNoNoNo49
16R1.1x60 R1.I1x47 mglu_off27.29721.90801YesNoYesYes49
17R1.I1x47 R1.I1x49 mglu_off26.02372.4253YesYesNoNo97
18R1.3x46 R1.6x33 mglu_off12.91480YesNoNoNo99
19R1.6x33 R1.I3 mglu_off14.02550NoNoYesYes98
20R1.I1x49 R1.I3 mglu_off25.04380NoNoYesYes78
21R1.2x56 R1.2x60 mglu_off12.28475.14882YesNoYesNo78
22R1.3x29 R1.E2 mglu_off10.54940YesYesYesYes86
23R1.7x32 R1.E3 mglu_off10.41320.496062YesYesYesNo58
24R2.7x32 R2.NT mglu_off14.86563.66353YesYesYesYes55
25R2.3x29 R2.E2 mglu_off95.7950YesYesYesYes86
26R2.3x29 R2.5x40 mglu_off15.02670YesYesNoNo87
27R2.5x40 R2.6x55 mglu_off14.50070NoNoYesNo78
28R2.6x55 R2.7x38 mglu_off10.66590YesNoNoNo89
29R2.3x29 R2.5x39 mglu_off99.99290YesYesNoYes86
30R2.4x60 R2.5x39 mglu_off1000.638897YesNoNoYes76
31R2.4x56 R2.4x60 mglu_off50.00580NoNoYesNo77
32R2.4x53 R2.4x56 mglu_off49.85540YesNoNoNo97
33R2.4x53 R2.5x46 mglu_off97.88731.17839YesNoYesYes98
34R2.5x46 R2.5x50 mglu_off86.96150.00579061YesYesNoNo89
35R2.3x40 R2.5x50 mglu_off75.88080.582922YesYesNoNo69
36R2.3x40 R2.5x47 mglu_off75.04340YesYesNoNo67
37R2.3x36 R2.5x47 mglu_off74.50140.00386041YesYesNoNo87
38R2.3x36 R2.7x42 mglu_off69.54350.644688YesYesYesNo88
39R2.4x60 R2.5x43 mglu_off50.00580YesNoNoNo77
40R2.4x53 R2.5x43 mglu_off49.85540YesNoNoNo97
41R2.2x50 R2.7x42 mglu_off55.76460NoYesYesNo88
42R2.1x50 R2.2x50 mglu_off55.61771.05293NoNoNoYes78
43R2.1x50 R2.2x47 mglu_off53.19710NoNoYesYes79
44R2.2x47 R2.7x53 mglu_off43.87415.21541YesYesYesYes99
45R2.1x57 R2.2x44 mglu_off12.45830YesYesYesNo98
46R2.7x53 R2.7x56 mglu_off15.14069.36245YesYesNoNo99
47R2.1x60 R2.7x56 mglu_off14.50510NoNoNoNo49
48R2.1x60 R2.I1x47 mglu_off13.1560NoNoYesNo49
49R2.6x40 R2.7x52 mglu_off11.52651.06065YesYesNoNo96
50R2.6x36 R2.7x52 mglu_off10.84570NoNoNoNo56
51R2.4x49 R2.5x46 mglu_off13.77810NoNoYesYes58
52R2.4x45 R2.4x49 mglu_off12.33990NoNoNoNo75
53R2.4x42 R2.4x45 mglu_off11.61820NoNoNoNo87
54R2.2x53 R2.7x42 mglu_off11.7890NoNoYesNo68
55R2.2x53 R2.3x35 mglu_off11.06550.589677NoNoNoNo66
56R2.2x52 R2.3x35 mglu_off10.34021.17839YesNoNoNo56
57R2.3x44 R2.5x50 mglu_off10.57870YesNoNoNo99
58R1.7x50 R1.7x53 Shared40.300174.1526YesYesYesYes89
59R1.E2 R1.NT Shared15.418263.1476YesYesYesYes65
60R1.NT R2.NT Shared98.5138100YesYesYesYes55
61R2.E2 R2.NT Shared93.885295.5065YesYesYesYes65
62R2.7x521 R2.7x53 Shared18.382647.7031NoNoYesYes89
63R2.6x40 R2.7x521 Shared16.329548.5842YesYesNoNo98
64R1.1x43 R1.2x57 mglu_on3.0115680.5358NoNoNoNo77
65R1.1x43 R1.2x58 mglu_on2.4126380.8109NoNoNoNo77
66R1.1x40 R1.2x58 mglu_on1.2094381.3668NoNoNoNo57
67R1.1x40 R1.NT mglu_on081.9246NoNoYesYes55
68R1.2x57 R1.7x43 mglu_on0.6051680.696NoNoNoNo78
69R1.2x54 R1.7x43 mglu_on080.0764YesYesNoNo88
70R1.2x54 R1.7x50 mglu_on073.6122YesYesYesYes88
71R1.1x57 R1.7x53 mglu_on4.3402467.1055YesYesYesYes99
72R1.2x40 R1.I1 mglu_on0.5989358.6676YesYesNoNo94
73R1.I1 R1.I1x50 mglu_on059.0942NoNoNoNo49
74R1.1x57 R1.I1x50 mglu_on063.9959YesYesNoNo99
75R1.2x40 R1.2x41 mglu_on0.5989356.5058YesYesNoNo96
76R1.2x41 R1.4x39 mglu_on055.1855NoNoNoNo66
77R1.2x42 R1.3x46 mglu_on8.5167417.1972NoNoYesNo89
78R1.3x46 R1.I3 mglu_on018.3283YesNoYesYes98
79R1.6x37 R1.I3 mglu_on043.1777NoYesYesYes98
80R1.6x37 R1.6x41 mglu_on022.7146NoYesYesYes99
81R1.5x54 R1.6x41 mglu_on0.0017798824.2723NoNoYesYes99
82R1.3x44 R1.5x54 mglu_on047.897YesNoNoNo99
83R1.3x44 R1.5x57 mglu_on4.1213249.31YesNoYesNo97
84R1.3x48 R1.5x57 mglu_on0.0035597650.2422NoNoYesNo67
85R1.3x48 R1.3x52 mglu_on050.7055NoNoNoYes67
86R1.3x52 R1.I2 mglu_on050.8348NoYesNoYes70
87R1.4x41 R1.I2 mglu_on053.3981NoNoNoYes70
88R1.4x38 R1.4x41 mglu_on0.53040553.8479NoNoNoNo77
89R1.4x38 R1.4x39 mglu_on1.5912154.7415NoNoNoNo76
90R1.3x43 R1.6x37 mglu_on022.6355NoNoNoYes89
91R1.3x43 R1.5x54 mglu_on0.59537123.1547NoNoNoNo89
92R1.2x42 R1.3x45 mglu_on014.9292NoNoNoYes87
93R1.4x53 R1.5x46 mglu_on4.0358814.9475YesYesYesYes98
94R1.5x46 R1.5x50 mglu_on7.3936321.5536YesYesNoNo89
95R1.3x40 R1.5x50 mglu_on8.4339723.1982YesYesNoNo69
96R1.3x36 R1.Allo1 mglu_on010.2938YesYesNoYes80
97R1.Allo1 R1.E2 mglu_on056.4092NoYesYesYes06
98R1.5x47 R1.Allo1 mglu_on010.3189NoNoNoYes70
99R1.3x40 R1.6x48 mglu_on010.1394YesYesYesYes69
100R1.6x48 R1.Allo1 mglu_on017.8071YesYesNoYes90
101R2.2x42 R2.3x46 mglu_on6.5161510.1741NoNoNoNo89
102R2.2x42 R2.3x45 mglu_on010.73NoNoNoYes87
103R2.3x45 R2.4x42 mglu_on2.2444317.2502NoYesNoNo78
104R2.4x41 R2.4x42 mglu_on018.3099NoNoNoNo78
105R2.4x41 R2.I2 mglu_on020.4061NoNoNoYes76
106R2.3x52 R2.I2 mglu_on0.66300621.9059NoNoNoYes76
107R2.3x48 R2.3x52 mglu_on1.4114522.4193NoNoNoNo67
108R2.3x44 R2.3x48 mglu_on027.3973YesNoNoNo96
109R2.3x40 R2.3x44 mglu_on1.8448552.0846YesYesYesNo69
110R2.3x40 R2.6x48 mglu_on055.6314YesYesYesYes69
111R2.6x48 R2.6x51 mglu_on087.6998YesYesYesYes99
112R2.6x51 R2.6x55 mglu_on089.7661YesYesYesNo98
113R2.5x37 R2.6x55 mglu_on087.252NoNoYesNo48
114R2.5x37 R2.E2 mglu_on087.6689NoNoYesYes46
115R1.6x54 R1.7x37 mglu_on0.99317414.7506NoYesNoNo78
116R1.6x51 R1.7x37 mglu_on4.9516316.3952NoYesNoNo98
117R2.E2 R2.E2x50 mglu_on019.0202YesYesNoNo69
118R2.3x29 R2.E2x50 mglu_on017.9258YesYesNoNo89
119R2.3x28 R2.3x29 mglu_on034.8585NoYesYesYes88
120R2.2x60 R2.3x28 mglu_on0.83031519.966YesYesNoYes88
121R2.2x60 R2.7x39 mglu_on6.5989116.483YesYesNoNo87
122R2.E2 R2.E2x52 mglu_on019.0164YesYesYesYes65
123R2.3x29 R2.E2x52 mglu_on3.5019217.9856YesYesYesYes85
124R2.2x57 R2.7x39 mglu_on4.9596411.8119NoNoNoNo77
125R2.3x44 R2.5x54 mglu_on5.9510430.3882YesNoNoNo99
126R2.5x54 R2.6x41 mglu_on4.4683929.9172NoNoYesYes99
127R2.6x40 R2.6x41 mglu_on051.4795YesYesYesYes99
128R2.7x50 R2.7x53 mglu_on0.74132113.6494NoNoYesYes89
129R2.2x50 R2.7x50 mglu_on011.5706NoYesNoNo88
130R2.5x51 R2.6x48 mglu_on029.9278NoYesYesYes89
131R2.5x51 R2.6x45 mglu_on0.7493329.2098NoYesNoNo87
132R2.5x55 R2.6x45 mglu_on028.7388NoNoNoNo87
133R2.5x55 R2.6x41 mglu_on0.7493326.9476NoNoYesYes89
134R2.1x57 R2.7x53 mglu_on7.0082914.3916YesYesYesYes99
135R2.1x57 R2.I1x51 mglu_on013.5568YesYesNoNo97
136R2.I1 R2.I1x51 mglu_on010.5379NoYesNoNo57
137R2.2x59 R2.3x28 mglu_on011.8119NoNoNoYes58
138R2.2x59 R2.3x27 mglu_on0.7493310.6393NoNoNoNo55

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Midway



Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Node1Node2OwnerNet1LinkStrengthNet2LinkStrengthComm1Comm2Node1ShellNode2Shell
R1.NTR1.NTShared3731.584085.961122
R1.NTR2.NTShared103.715169.41121
R2.NTR2.NTShared3714.014087.251111
R2.LigR2.NTShared7380.930001
R2.E2R2.NTShared62.961763.37751121
R2.7x32R2.NTShared4.593337.071121
R2.1x33R2.7x32mglu_off3.1766701022
R2.E1R2.E1Shared5.5654.051122
R2.E1R2.E2Shared7.588337.56751122
R2.E2R2.E2Shared60.916778.83751122
R2.7x31R2.7x32Shared5.486674.58750122
R2.E1R2.NTShared3.888337.13751121
R2.1x34R2.NTShared3.756671.780021
R2.1x36R2.NTmglu_off3.4500021
R2.1x32R2.NTShared0.50.88250021
R2.7x31R2.NTmglu_on04.39250121
R2.2x61R2.NTmglu_on03.230121
R2.1x33R2.NTmglu_on02.681021
R2.7x31R2.E2mglu_on011.7650122
R2.7x32R2.E2mglu_on07.131122
R2.1x36R2.2x61mglu_on02.030022
R2.2x62R2.NTmglu_on01.29750021

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

2D representation of the interactions of this orthosteric/allosteric ligand.


Node1Node2OwnerNet1LinkStrengthNet2LinkStrengthComm1Comm2Node1ShellNode2Shell
R1.NTR1.NTShared3731.584085.961111
R1.LigR1.NTShared72.576774.4850001
R1.NTR2.NTShared103.715169.41112
R1.E2R1.NTShared75.48583.1051121
R1.7x31R1.NTShared6.854.8550121
R1.E1R1.NTShared8.3983312.9551121
R1.7x32R1.NTShared2.9233310.141121
R1.E1R1.E1Shared4.451673.2551122
R1.E1R1.E2Shared6.191679.921122
R1.E2R1.E2Shared65.9488.75251122
R1.7x32R1.7x35mglu_off2.5866701122
R2.NTR2.NTShared3714.014087.251122
R1.1x34R1.NTmglu_off3.7566700021
R1.1x36R1.NTShared3.450.88250021
R1.1x33R1.NTShared1.796671.24250021
R1.7x31R1.E2mglu_on09.39750122
R1.7x35R1.NTmglu_on03.190121
R1.7x32R1.E2mglu_on03.73251122
R1.7x35R1.E2mglu_on03.7550122
R1.1x40R1.NTmglu_on02.45250121
R1.1x32R1.NTmglu_on01.2350021

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
Id Description
mglu_off mglu2_off
mglu3_off
mglu5_off
mglu_on mglu2_on
mglu4_on
Network Difference
Value mglu_off mglu_on
Imin 2.57167 2.49
Number of Linked Nodes 443 467
Number of Specific Nodes 6 (1.35%) 30  (6.42%)
Number of Shared Nodes 437 (98.65%) 437  (93.58%)
Number of Links 490 528
Number of Specific Links 253 (51.63%) 291  (55.11%)
Number of Shared Links 237 (48.37%) 237  (44.89%)
Number of Hubs 67 63
Number of Specific Hubs 24 (35.82%) 20  (31.75%)
Number of Shared Hubs 43 (64.18%) 43  (68.25%)
Average % Shared Neighbours (Jaccard) 32.60
Average % Shared Neighbours (Otsuka) 41.45
Average % Shared Neighbours (Overlap Coefficient) 49.85
Average % Shared Cliques (k3-6) 51.56
Graphlets Similarity 0.603747
Paths Difference
Value mglu_off mglu_on
Number Of Nodes in MetaPath 64 80
Specific Nodes in MetaPath 44 (68.75%) 60  (75.00%)
Shared Nodes in MetaPath 437 (98.65%) 437  (98.65%)
Number Of Links MetaPath 63 81
Specific Links in MetaPath 57 (90.48%) 75  (92.59%)
Shared Links in MetaPath 237 (48.37%) 237  (48.37%)
Number of Shortest Paths 180733 202048
Length Of Smallest Path 3 3
Average Path Length 22.7841 21.8901
Length of Longest Path 53 57
Minimum Path Strength 0.529167 0.855
Average Path Strength 9.29883 11.6526
Maximum Path Strength 65.1925 89.77
Minimum Path Correlation 0.703333 0.7
Average Path Correlation 0.978361 0.974993
Maximum Path Correlation 1 1
Minimum % Of Corr. Nodes 3.33333 2.17391
Average % Of Corr. Nodes 63.4494 63.5988
Maximum % Of Corr. Nodes 100 100
Minimum Path Hubs % 0 0
Average Path Hubs % 52.2591 46.7504
Maximum Path Hubs % 100 100

Details about the values in these tables can be found in the corresponding documentation page .

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

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