psnGPCR

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Orange: nodes, hubs and links specific of muscarinic_on network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of muscarinic_off network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	muscarinic_on Int. Strength	muscarinic_off Int. Strength	muscarinic_on Hub1?	muscarinic_off Hub1?	muscarinic_on Hub2?	muscarinic_off Hub2?	ConSurf1	ConSurf2
1	1x29	1x30	muscarinic_on	100	0	No	No	No	No	5	3
2	1x30	1x31	muscarinic_on	100	0	No	No	Yes	No	3	5
3	2x39	3x49	muscarinic_on	100	0	No	No	Yes	No	9	9
4	2x46	2x50	muscarinic_on	100	0	No	No	Yes	Yes	9	9
5	2x46	3x43	muscarinic_on	100	0	No	No	No	No	9	9
6	2x46	7x49	muscarinic_on	100	0	No	No	No	No	9	9
7	2x53	3x35	muscarinic_on	100	0	No	No	No	No	8	7
8	3x33	6x51	muscarinic_on	100	0	Yes	Yes	Yes	No	8	8
9	3x40	6x48	muscarinic_on	100	0	No	No	Yes	Yes	9	9
10	3x42	4x50	muscarinic_on	100	0	No	No	Yes	No	9	9
11	3x43	7x53	muscarinic_on	100	0	No	No	Yes	Yes	9	9
12	3x44	3x48	muscarinic_on	100	0	No	No	No	No	7	7
13	3x46	3x50	muscarinic_on	100	0	No	No	No	Yes	9	9
14	3x46	7x53	muscarinic_on	100	0	No	No	Yes	Yes	9	9
15	3x47	5x58	muscarinic_on	100	0	No	No	Yes	Yes	9	9
16	3x50	5x58	muscarinic_on	100	0	No	Yes	Yes	Yes	9	9
17	3x50	7x53	muscarinic_on	100	0	No	Yes	Yes	Yes	9	9
18	I2x52	I2x56	muscarinic_on	100	0	No	No	No	No	6	6
19	4x56	4x57	muscarinic_on	100	0	No	No	Yes	Yes	8	8
20	4x57	5x43	muscarinic_on	100	0	Yes	Yes	No	No	8	9
21	4x64	5x36	muscarinic_on	100	0	No	No	No	No	6	7
22	5x40	6x59	muscarinic_on	100	0	No	No	Yes	No	8	7
23	5x48	6x56	muscarinic_on	100	0	Yes	No	No	No	8	7
24	5x51	6x44	muscarinic_on	100	0	No	No	Yes	Yes	7	9
25	5x55	6x41	muscarinic_on	100	0	No	No	No	No	6	8
26	5x58	6x37	muscarinic_on	100	0	Yes	Yes	No	No	9	9
27	5x58	6x40	muscarinic_on	100	0	Yes	Yes	Yes	No	9	9
28	5x62	6x34	muscarinic_on	100	0	No	No	No	No	8	8
29	5x65	6x33	muscarinic_on	100	0	No	No	No	No	8	8
30	5x66	6x30	muscarinic_on	100	0	Yes	No	No	Yes	7	9
31	6x51	6x52	muscarinic_on	100	0	Yes	No	No	No	8	7
32	6x51	6x55	muscarinic_on	100	0	Yes	No	No	No	8	8
33	6x58	E3	muscarinic_on	100	0	No	No	Yes	Yes	4	5
34	7x34	7x38	muscarinic_on	100	0	Yes	Yes	Yes	Yes	6	7
35	7x55	8x54	muscarinic_on	100	0	No	No	No	Yes	7	9
36	8x52	8x55	muscarinic_on	100	0	No	No	No	No	6	7
37	3x37	Lig	muscarinic_on	100	0	Yes	No	Yes	Yes	9	0
38	3x40	6x44	muscarinic_on	100	0	No	No	Yes	Yes	9	9
39	6x30	6x31	muscarinic_on	100	0	No	Yes	Yes	Yes	9	7
40	CT	CT	muscarinic_on	100	0	Yes	Yes	Yes	Yes	0	0
41	1x50	2x51	muscarinic_on	45.8333	0	No	No	No	No	9	8
42	5x37	6x59	muscarinic_on	50	0	No	No	Yes	No	4	7
43	3x44	5x53	muscarinic_on	31.25	0	No	No	No	No	7	7
44	5x47	6x49	muscarinic_on	58.3333	0	Yes	Yes	No	No	9	7
45	1x53	2x47	muscarinic_on	0	0	No	No	No	No	9	9
46	3x53	I2x54	muscarinic_on	25	0	No	No	No	No	8	7
47	7x54	8x50	muscarinic_on	50	0	No	No	Yes	Yes	8	9
48	3x51	5x61	muscarinic_on	33.3333	0	Yes	Yes	No	No	9	9
49	2x38	4x39	muscarinic_on	50	0	No	No	No	No	7	5
50	2x61	2x65	muscarinic_on	25	0	No	No	Yes	No	7	6
51	1x37	1x41	muscarinic_on	25	0	No	No	No	No	4	5
52	E1x50	E1x51	muscarinic_on	50	0	Yes	Yes	No	No	9	4
53	3x54	5x61	muscarinic_on	25	0	No	No	No	No	8	9
54	1x40	1x43	muscarinic_on	31.25	0	No	No	No	No	4	8
55	3x26	4x62	muscarinic_on	14.5833	0	No	No	Yes	No	7	6
56	7x48	7x52	muscarinic_on	31.25	0	No	No	No	No	6	9
57	1x54	2x47	muscarinic_on	0	0	No	No	No	No	7	9
58	7x31	7x34	muscarinic_on	33.3333	0	No	No	Yes	Yes	4	6
59	5x62	6x37	muscarinic_on	25	0	No	No	No	No	8	9
60	1x57	1x58	muscarinic_on	25	0	Yes	Yes	No	No	8	5
61	5x68	5x72	muscarinic_on	33.3333	0	No	No	No	No	8	0
62	6x36	6x40	muscarinic_on	0	0	No	No	Yes	No	9	9
63	4x48	4x52	muscarinic_on	8.33333	0	No	No	No	No	4	6
64	4x67	4x68	muscarinic_on	25	0	No	No	No	No	5	4
65	8x58	CT	muscarinic_on	25	0	No	No	Yes	Yes	0	0
66	5x68	5x69	muscarinic_on	25	0	No	No	No	No	8	5
67	5x65	5x66	muscarinic_on	25	0	No	No	Yes	No	8	7
68	5x44	5x48	muscarinic_on	0	0	No	No	Yes	No	8	8
69	6x34	6x38	muscarinic_on	6.25	0	No	No	No	No	8	7
70	5x48	6x53	muscarinic_on	0	0	Yes	No	No	No	8	7
71	3x21	3x24	muscarinic_on	0	0	No	No	No	No	7	6
72	1x52	8x57	muscarinic_on	25	0	No	No	No	No	8	0
73	5x67	5x69	muscarinic_on	0	0	No	No	No	No	6	5
74	1x55	1x59	muscarinic_on	6.25	0	No	No	No	No	6	7
75	5x41	5x42	muscarinic_on	0	0	No	No	No	No	7	6
76	7x55	8x51	muscarinic_on	0	0	No	No	No	No	7	9
77	8x55	8x59	muscarinic_on	25	0	No	No	No	No	7	0
78	4x38	4x39	muscarinic_on	25	0	No	No	No	No	9	5
79	6x32	6x36	muscarinic_on	6.25	0	No	No	No	No	9	9
80	6x31	6x35	muscarinic_on	6.25	0	Yes	Yes	No	No	7	8
81	7x32	7x35	muscarinic_on	0	0	No	No	No	No	4	6
82	5x66	5x68	muscarinic_on	12.5	0	Yes	No	No	No	7	8
83	4x68	4x69	muscarinic_on	0	0	No	No	No	No	4	5
84	5x67	6x29	muscarinic_on	6.25	0	No	No	No	No	6	7
85	5x67	5x71	muscarinic_on	8.33333	0	No	No	No	No	6	0
86	4x56	5x46	muscarinic_on	0	0	No	No	No	No	8	6
87	2x66	2x67	muscarinic_on	0	0	Yes	No	No	No	6	6
88	5x69	5x70	muscarinic_on	0	0	No	No	No	No	5	6
89	6x25	6x26	muscarinic_on	0	0	No	No	No	No	5	5
90	6x26	6x27	muscarinic_on	0	0	No	No	No	No	5	4
91	1x29	1x32	muscarinic_on	0	0	No	No	No	No	5	4
92	5x63	5x66	muscarinic_on	6.25	0	No	No	Yes	No	5	7
93	1x34	1x37	muscarinic_on	0	0	No	No	No	No	3	4
94	1x26	1x31	muscarinic_on	6.25	0	No	No	Yes	No	0	5
95	8x56	8x60	muscarinic_on	0	0	No	No	No	No	6	0
96	6x35	6x39	muscarinic_on	0	0	No	No	No	No	8	8
97	1x27	1x31	muscarinic_on	0	0	No	No	Yes	No	0	5
98	1x39	2x61	Shared	100	100	No	Yes	No	No	7	7
99	1x39	7x39	Shared	100	100	No	Yes	Yes	Yes	7	9
100	1x42	7x39	Shared	100	60	No	No	Yes	Yes	6	9
101	1x43	2x58	Shared	100	100	No	No	No	No	8	9
102	1x46	2x57	Shared	100	100	No	No	Yes	Yes	8	9
103	1x46	7x47	Shared	100	100	No	No	No	No	8	7
104	1x50	2x50	Shared	100	100	No	No	Yes	Yes	9	9
105	1x50	7x50	Shared	100	100	No	No	No	No	9	9
106	1x52	8x54	Shared	100	100	No	No	No	Yes	8	9
107	1x54	2x44	Shared	100	100	No	No	No	No	7	7
108	1x57	2x44	Shared	100	100	Yes	Yes	No	No	8	7
109	1x60	I1x49	Shared	100	100	Yes	Yes	No	No	8	6
110	1x60	I1x50	Shared	100	100	Yes	Yes	No	Yes	8	9
111	1x60	8x53	Shared	100	100	Yes	Yes	No	No	8	8
112	8x49	I1x50	Shared	100	100	No	No	No	Yes	7	9
113	8x50	I1x50	Shared	100	100	Yes	Yes	No	Yes	9	9
114	2x37	2x40	Shared	100	100	No	No	Yes	Yes	8	9
115	2x38	I2x57	Shared	100	100	No	No	Yes	Yes	7	8
116	2x42	3x45	Shared	100	100	Yes	Yes	No	No	8	8
117	2x42	3x49	Shared	100	100	Yes	Yes	Yes	No	8	9
118	2x42	4x46	Shared	100	100	Yes	Yes	Yes	Yes	8	9
119	2x45	3x42	Shared	100	100	No	No	No	No	9	9
120	2x45	4x46	Shared	100	100	No	No	Yes	Yes	9	9
121	2x45	4x50	Shared	100	100	No	No	Yes	No	9	9
122	2x50	7x46	Shared	100	100	Yes	Yes	No	No	9	9
123	2x50	7x49	Shared	100	100	Yes	Yes	No	No	9	9
124	2x52	3x35	Shared	100	40	No	No	No	No	8	7
125	2x53	2x56	Shared	100	100	No	No	No	No	8	8
126	2x53	7x46	Shared	100	100	No	No	No	No	8	9
127	2x55	2x551	Shared	100	100	No	No	No	No	5	5
128	2x56	3x32	Shared	100	100	No	No	No	Yes	8	9
129	2x56	7x42	Shared	100	100	No	No	Yes	Yes	8	9
130	2x57	7x39	Shared	100	100	Yes	Yes	Yes	Yes	9	9
131	2x57	7x42	Shared	100	100	Yes	Yes	Yes	Yes	9	9
132	2x59	3x28	Shared	100	100	No	No	Yes	Yes	7	7
133	2x60	2x64	Shared	100	100	Yes	Yes	No	No	8	7
134	2x60	3x28	Shared	100	100	Yes	Yes	Yes	Yes	8	7
135	2x60	7x38	Shared	100	100	Yes	Yes	Yes	Yes	8	7
136	2x60	7x39	Shared	100	100	Yes	Yes	Yes	Yes	8	9
137	2x60	7x42	Shared	100	100	Yes	Yes	Yes	Yes	8	9
138	2x63	E1x50	Shared	100	100	No	No	Yes	Yes	7	9
139	2x64	7x35	Shared	100	100	No	No	No	No	7	6
140	E1x50	E1x52	Shared	100	100	Yes	Yes	No	No	9	8
141	3x25	E1x50	Shared	100	100	No	No	Yes	Yes	9	9
142	3x28	E1x50	Shared	100	100	Yes	Yes	Yes	Yes	7	9
143	E1x50	E2x50	Shared	100	100	Yes	Yes	No	No	9	9
144	3x24	E1x52	Shared	100	100	No	No	No	No	6	8
145	3x22	E2	Shared	100	100	No	No	Yes	Yes	4	5
146	3x25	E2x50	Shared	100	100	No	No	No	No	9	9
147	3x26	4x65	Shared	100	100	No	No	No	No	7	7
148	3x28	3x29	Shared	100	100	Yes	Yes	No	No	7	7
149	3x29	E2x52	Shared	100	100	No	No	Yes	Yes	7	7
150	3x32	7x42	Shared	100	100	No	Yes	Yes	Yes	9	9
151	3x32	Lig	Shared	100	100	No	Yes	Yes	Yes	9	0
152	3x33	4x57	Shared	100	100	Yes	Yes	Yes	Yes	8	8
153	3x33	E2x52	Shared	100	100	Yes	Yes	Yes	Yes	8	7
154	3x33	7x38	Shared	100	100	Yes	Yes	Yes	Yes	8	7
155	3x33	Lig	Shared	100	100	Yes	Yes	Yes	Yes	8	0
156	3x36	Lig	Shared	100	100	No	No	Yes	Yes	8	0
157	3x37	3x41	Shared	100	40	Yes	No	No	No	9	8
158	3x37	4x53	Shared	100	100	Yes	No	No	No	9	9
159	3x37	4x57	Shared	100	100	Yes	No	Yes	Yes	9	8
160	3x38	4x50	Shared	100	100	No	No	Yes	No	8	9
161	3x47	5x57	Shared	100	6.66667	No	No	No	Yes	9	8
162	3x48	5x57	Shared	100	100	No	No	No	Yes	7	8
163	3x49	I2x53	Shared	100	100	Yes	No	Yes	Yes	9	9
164	3x49	I2x57	Shared	100	100	Yes	No	Yes	Yes	9	8
165	3x51	3x52	Shared	100	100	Yes	Yes	No	Yes	9	6
166	3x51	3x55	Shared	100	100	Yes	Yes	No	No	9	8
167	3x51	5x57	Shared	100	100	Yes	Yes	No	Yes	9	8
168	3x51	5x60	Shared	100	100	Yes	Yes	No	No	9	6
169	3x52	I2x53	Shared	100	100	No	Yes	Yes	Yes	6	9
170	3x56	I2x52	Shared	100	100	No	Yes	No	No	7	6
171	I2x53	I2x57	Shared	100	100	Yes	Yes	Yes	Yes	9	8
172	4x38	4x40	Shared	100	20	No	No	No	No	9	5
173	4x38	4x41	Shared	100	100	No	No	No	No	9	8
174	4x54	4x58	Shared	100	100	No	No	No	No	5	6
175	4x57	Lig	Shared	100	100	Yes	Yes	Yes	Yes	8	0
176	4x61	E2x52	Shared	100	100	No	No	Yes	Yes	8	7
177	4x64	4x68	Shared	100	100	No	No	No	No	6	4
178	4x64	E2	Shared	100	100	No	No	Yes	Yes	6	5
179	4x65	4x66	Shared	100	100	No	No	No	No	7	6
180	4x65	E2	Shared	100	100	No	No	Yes	Yes	7	5
181	E2	E2	Shared	100	100	Yes	Yes	Yes	Yes	5	5
182	E2	E2x51	Shared	100	100	Yes	Yes	No	No	5	4
183	E2	E2x52	Shared	100	100	Yes	Yes	Yes	Yes	5	7
184	5x39	E2	Shared	100	26.6667	No	No	Yes	Yes	8	5
185	5x40	E2	Shared	100	100	No	No	Yes	Yes	8	5
186	5x36	5x39	Shared	100	100	No	No	No	No	7	8
187	5x41	6x56	Shared	100	100	No	No	No	No	7	7
188	5x41	6x59	Shared	100	100	No	No	Yes	No	7	7
189	5x45	5x48	Shared	100	40	No	No	Yes	No	7	8
190	5x47	5x48	Shared	100	100	Yes	Yes	Yes	No	9	8
191	5x47	6x44	Shared	100	100	Yes	Yes	Yes	Yes	9	9
192	5x47	6x48	Shared	100	100	Yes	Yes	Yes	Yes	9	9
193	5x47	6x52	Shared	100	100	Yes	Yes	No	No	9	7
194	5x58	6x41	Shared	100	6.66667	Yes	Yes	No	No	9	8
195	5x59	5x63	Shared	100	100	No	No	No	No	4	5
196	6x40	7x53	Shared	100	100	Yes	No	Yes	Yes	9	9
197	6x44	6x48	Shared	100	100	Yes	Yes	Yes	Yes	9	9
198	6x45	6x49	Shared	100	0	No	No	No	No	7	7
199	6x47	6x48	Shared	100	100	No	No	Yes	Yes	9	9
200	6x47	7x45	Shared	100	100	No	No	No	Yes	9	9
201	6x48	7x45	Shared	100	100	Yes	Yes	No	Yes	9	9
202	6x48	Lig	Shared	100	100	Yes	Yes	Yes	Yes	9	0
203	6x51	7x38	Shared	100	100	Yes	No	Yes	Yes	8	7
204	6x51	Lig	Shared	100	100	Yes	No	Yes	Yes	8	0
205	6x57	E3	Shared	100	100	No	No	Yes	Yes	7	5
206	6x58	7x34	Shared	100	100	No	No	Yes	Yes	4	6
207	6x59	6x60	Shared	100	100	Yes	No	No	No	7	7
208	6x61	E3	Shared	100	100	No	No	Yes	Yes	7	5
209	E3	E3	Shared	100	100	Yes	Yes	Yes	Yes	5	5
210	7x34	E3	Shared	100	100	Yes	Yes	Yes	Yes	6	5
211	7x30	7x33	Shared	100	100	No	No	No	No	7	5
212	7x38	7x42	Shared	100	100	Yes	Yes	Yes	Yes	7	9
213	7x38	Lig	Shared	100	100	Yes	Yes	Yes	Yes	7	0
214	7x39	7x42	Shared	100	100	Yes	Yes	Yes	Yes	9	9
215	7x41	Lig	Shared	100	100	No	No	Yes	Yes	8	0
216	7x42	Lig	Shared	100	100	Yes	Yes	Yes	Yes	9	0
217	7x45	7x49	Shared	100	100	No	Yes	No	No	9	9
218	8x47	8x49	Shared	100	100	No	No	No	No	9	7
219	8x47	8x50	Shared	100	100	No	No	Yes	Yes	9	9
220	1x56	8x53	Shared	100	100	No	No	No	No	9	8
221	2x39	I2x57	Shared	100	100	No	No	Yes	Yes	9	8
222	2x40	8x50	Shared	100	100	Yes	Yes	Yes	Yes	9	9
223	3x26	E2	Shared	100	100	No	No	Yes	Yes	7	5
224	5x47	5x51	Shared	100	100	Yes	Yes	No	No	9	7
225	5x62	5x66	Shared	100	20	No	No	Yes	No	8	7
226	6x48	7x41	Shared	100	100	Yes	Yes	No	No	9	8
227	2x54	2x57	Shared	58.3333	100	No	No	Yes	Yes	8	9
228	3x47	5x54	Shared	31.25	100	No	No	No	No	9	9
229	1x56	8x54	Shared	56.25	100	No	No	No	Yes	9	9
230	I1x48	I1x51	Shared	50	100	No	No	No	No	8	8
231	6x49	6x50	Shared	31.25	40	No	No	No	No	7	9
232	3x53	I2x53	Shared	66.6667	100	No	No	Yes	Yes	8	9
233	3x45	4x45	Shared	31.25	20	No	No	No	No	8	8
234	5x49	5x50	Shared	25	100	No	No	No	No	7	9
235	1x34	1x38	Shared	68.75	100	No	No	No	No	3	4
236	6x54	E3	Shared	33.3333	100	No	No	Yes	Yes	7	5
237	4x62	4x63	Shared	50	100	Yes	No	No	No	6	7
238	6x50	7x40	Shared	31.25	100	No	No	No	No	9	8
239	7x30	E3	Shared	31.25	60	No	No	Yes	Yes	7	5
240	3x30	4x62	Shared	27.0833	46.6667	No	No	Yes	No	8	6
241	3x34	4x54	Shared	33.3333	26.6667	No	No	No	No	8	5
242	3x40	5x50	Shared	31.25	66.6667	No	No	No	No	9	9
243	2x50	3x39	Shared	14.5833	100	Yes	Yes	No	No	9	9
244	1x57	2x41	Shared	56.25	100	Yes	Yes	No	No	8	8
245	2x40	2x43	Shared	52.0833	46.6667	Yes	Yes	No	No	9	8
246	8x48	8x51	Shared	25	20	No	No	No	No	5	9
247	2x66	E1x49	Shared	50	100	Yes	No	No	Yes	6	4
248	2x49	4x50	Shared	8.33333	0	No	No	Yes	No	9	9
249	1x60	CT	Shared	25	20	Yes	Yes	Yes	Yes	8	0
250	6x40	7x52	Shared	31.25	26.6667	Yes	No	No	No	9	9
251	1x43	2x57	Shared	14.5833	100	No	No	Yes	Yes	8	9
252	2x66	E1x51	Shared	25	100	Yes	No	No	No	6	4
253	3x34	4x53	Shared	25	0	No	No	No	No	8	9
254	1x57	2x40	Shared	25	40	Yes	Yes	Yes	Yes	8	9
255	7x39	7x43	Shared	31.25	26.6667	Yes	Yes	No	No	9	6
256	2x551	3x31	Shared	39.5833	100	No	No	No	No	5	6
257	1x57	I1x51	Shared	50	100	Yes	Yes	No	No	8	8
258	2x41	4x39	Shared	8.33333	100	No	No	No	No	8	5
259	5x461	Lig	Shared	20.8333	100	No	No	Yes	Yes	8	0
260	3x54	5x64	Shared	25	0	No	No	No	No	8	7
261	3x55	3x56	Shared	31.25	100	No	No	No	Yes	8	7
262	5x56	5x60	Shared	6.25	60	No	No	No	No	5	6
263	7x51	7x55	Shared	25	26.6667	No	No	No	No	7	7
264	4x60	E2	Shared	14.5833	100	No	No	Yes	Yes	7	5
265	1x59	CT	Shared	25	100	No	No	Yes	Yes	7	0
266	2x42	4x42	Shared	12.5	40	Yes	Yes	No	No	8	8
267	4x40	4x44	Shared	31.25	13.3333	No	No	No	No	5	4
268	6x36	7x56	Shared	6.25	40	No	No	No	No	9	9
269	8x48	8x52	Shared	25	20	No	No	No	No	5	6
270	4x58	4x59	Shared	6.25	13.3333	No	No	No	No	6	8
271	2x52	3x31	Shared	31.25	100	No	No	No	No	8	6
272	1x51	2x51	Shared	33.3333	60	No	No	No	No	6	8
273	1x54	2x48	Shared	0	6.66667	No	No	No	No	7	7
274	3x41	4x52	Shared	0	40	No	No	No	No	8	6
275	1x49	7x50	Shared	25	60	No	No	No	No	9	9
276	1x48	1x52	Shared	0	0	No	No	No	No	5	8
277	5x36	5x38	Shared	31.25	100	No	No	No	No	7	4
278	6x43	7x48	Shared	0	46.6667	No	No	No	No	8	6
279	1x47	2x55	Shared	0	40	No	No	No	No	7	5
280	4x43	4x46	Shared	25	33.3333	No	No	Yes	Yes	4	9
281	3x41	4x49	Shared	0	26.6667	No	No	No	No	8	8
282	1x35	2x65	Shared	6.25	40	No	No	Yes	No	6	6
283	3x56	I2x50	Shared	0	0	No	Yes	No	No	7	9
284	1x44	1x48	Shared	0	20	No	No	No	No	6	5
285	8x56	CT	Shared	25	40	No	No	Yes	Yes	6	0
286	6x54	7x37	Shared	0	6.66667	No	No	No	No	7	6
287	1x36	2x65	Shared	0	0	No	No	Yes	No	5	6
288	6x42	6x46	Shared	6.25	26.6667	No	No	No	No	7	5
289	3x27	4x62	Shared	6.25	0	No	No	Yes	No	6	6
290	1x32	2x65	Shared	6.25	100	No	No	Yes	No	4	6
291	1x45	7x47	Shared	0	6.66667	No	No	No	No	5	7
292	I2x51	I2x52	Shared	6.25	0	No	No	No	No	7	6
293	4x51	4x55	Shared	0	6.66667	No	No	No	No	5	5
294	7x36	7x37	Shared	0	0	No	No	No	No	5	6
295	1x38	1x42	Shared	0	0	No	No	No	No	4	6
296	5x52	5x56	Shared	0	0	No	No	No	No	5	5
297	6x28	6x31	Shared	6.25	6.66667	No	No	Yes	Yes	5	7
298	1x28	1x31	Shared	8.33333	100	No	No	Yes	No	5	5
299	3x23	3x27	Shared	0	100	No	No	No	No	4	6
300	2x62	2x66	Shared	6.25	40	No	No	Yes	No	5	6
301	6x38	6x42	Shared	0	20	No	No	No	No	7	7
302	6x27	6x31	Shared	0	20	No	No	Yes	Yes	4	7
303	E1	E1x49	Shared	8.33333	0	No	No	No	Yes	0	4
304	4x54	4x55	Shared	0	0	No	No	No	No	5	5
305	1x33	1x37	Shared	0	6.66667	No	No	No	No	6	4
306	4x46	4x47	Shared	0	53.3333	Yes	Yes	No	No	9	4
307	I2x55	I2x56	Shared	0	0	No	No	No	No	5	6
308	1x50	2x47	muscarinic_off	0	100	No	No	No	No	9	9
309	1x53	7x53	muscarinic_off	0	100	No	No	Yes	Yes	9	9
310	1x55	8x57	muscarinic_off	0	100	No	No	No	No	6	0
311	2x40	I1x50	muscarinic_off	0	100	Yes	Yes	No	Yes	9	9
312	8x53	I1x50	muscarinic_off	0	100	No	No	No	Yes	8	9
313	2x42	3x46	muscarinic_off	0	100	Yes	Yes	No	No	8	9
314	2x43	7x53	muscarinic_off	0	100	No	No	Yes	Yes	8	9
315	2x46	3x39	muscarinic_off	0	100	No	No	No	No	9	9
316	2x46	3x42	muscarinic_off	0	100	No	No	No	No	9	9
317	2x53	7x42	muscarinic_off	0	100	No	No	Yes	Yes	8	9
318	2x60	7x35	muscarinic_off	0	100	Yes	Yes	No	No	8	6
319	3x28	3x32	muscarinic_off	0	100	Yes	Yes	No	Yes	7	9
320	3x29	E2x50	muscarinic_off	0	100	No	No	No	No	7	9
321	3x32	7x38	muscarinic_off	0	100	No	Yes	Yes	Yes	9	7
322	3x36	6x48	muscarinic_off	0	100	No	No	Yes	Yes	8	9
323	3x39	7x45	muscarinic_off	0	100	No	No	No	Yes	9	9
324	3x43	6x44	muscarinic_off	0	100	No	No	Yes	Yes	9	9
325	3x44	5x50	muscarinic_off	0	100	No	No	No	No	7	9
326	3x44	5x54	muscarinic_off	0	100	No	No	No	No	7	9
327	3x48	3x52	muscarinic_off	0	100	No	No	No	Yes	7	6
328	3x50	5x61	muscarinic_off	0	100	No	Yes	No	No	9	9
329	3x50	6x30	muscarinic_off	0	100	No	Yes	No	Yes	9	9
330	3x50	6x33	muscarinic_off	0	100	No	Yes	No	No	9	8
331	3x52	3x56	muscarinic_off	0	100	No	Yes	No	Yes	6	7
332	3x53	I2x57	muscarinic_off	0	100	No	No	Yes	Yes	8	8
333	4x57	E2	muscarinic_off	0	100	Yes	Yes	Yes	Yes	8	5
334	4x64	4x67	muscarinic_off	0	100	No	No	No	No	6	5
335	4x68	E2	muscarinic_off	0	100	No	No	Yes	Yes	4	5
336	5x43	E2	muscarinic_off	0	100	No	No	Yes	Yes	9	5
337	5x40	6x55	muscarinic_off	0	100	No	No	No	No	8	8
338	5x41	5x45	muscarinic_off	0	100	No	No	No	No	7	7
339	5x43	Lig	muscarinic_off	0	100	No	No	Yes	Yes	9	0
340	5x48	6x52	muscarinic_off	0	100	Yes	No	No	No	8	7
341	5x54	6x41	muscarinic_off	0	100	No	No	No	No	9	8
342	5x58	5x62	muscarinic_off	0	100	Yes	Yes	No	No	9	8
343	5x58	6x38	muscarinic_off	0	100	Yes	Yes	No	No	9	7
344	6x37	6x41	muscarinic_off	0	100	No	No	No	No	9	8
345	6x40	7x49	muscarinic_off	0	100	Yes	No	No	No	9	9
346	6x44	7x45	muscarinic_off	0	100	Yes	Yes	No	Yes	9	9
347	6x51	7x34	muscarinic_off	0	100	Yes	No	Yes	Yes	8	6
348	6x52	Lig	muscarinic_off	0	100	No	No	Yes	Yes	7	0
349	6x54	7x34	muscarinic_off	0	100	No	No	Yes	Yes	7	6
350	7x31	7x35	muscarinic_off	0	100	No	No	No	No	4	6
351	8x50	8x54	muscarinic_off	0	100	Yes	Yes	No	Yes	9	9
352	2x39	3x50	muscarinic_off	0	100	No	No	No	Yes	9	9
353	5x36	5x37	muscarinic_off	0	100	No	No	No	No	7	4
354	5x64	5x67	muscarinic_off	0	100	No	No	No	No	7	6
355	2x63	E2	muscarinic_off	0	100	No	No	Yes	Yes	7	5
356	5x51	6x45	muscarinic_off	0	60	No	No	No	No	7	7
357	8x51	8x55	muscarinic_off	0	46.6667	No	No	No	No	9	7
358	8x59	CT	muscarinic_off	0	26.6667	No	No	Yes	Yes	0	0
359	3x50	6x34	muscarinic_off	0	60	No	Yes	No	No	9	8
360	1x47	2x51	muscarinic_off	0	60	No	No	No	No	7	8
361	3x54	6x30	muscarinic_off	0	40	No	No	No	Yes	8	9
362	1x52	8x58	muscarinic_off	0	33.3333	No	No	No	No	8	0
363	1x54	2x51	muscarinic_off	0	60	No	No	No	No	7	8
364	6x39	7x52	muscarinic_off	0	40	No	No	No	No	8	9
365	5x53	5x57	muscarinic_off	0	0	No	No	No	Yes	7	8
366	7x54	8x54	muscarinic_off	0	20	No	No	No	Yes	8	9
367	1x56	8x57	muscarinic_off	0	40	No	No	No	No	9	0
368	6x32	8x47	muscarinic_off	0	26.6667	No	No	No	No	9	9
369	5x42	5x45	muscarinic_off	0	26.6667	No	No	No	No	6	7
370	4x52	4x56	muscarinic_off	0	6.66667	No	No	No	No	6	8
371	5x68	6x30	muscarinic_off	0	20	No	No	No	Yes	8	9
372	4x63	4x66	muscarinic_off	0	13.3333	No	No	No	No	7	6
373	E1x49	E2	muscarinic_off	0	0	No	Yes	Yes	Yes	4	5
374	1x31	NT	muscarinic_off	0	40	Yes	No	No	No	5	0
375	4x41	I2x56	muscarinic_off	0	40	No	No	No	No	8	6
376	4x41	4x45	muscarinic_off	0	40	No	No	No	No	8	8
377	5x68	6x31	muscarinic_off	0	20	No	No	Yes	Yes	8	7
378	3x21	E1x50	muscarinic_off	0	0	No	No	Yes	Yes	7	9
379	5x69	6x24	muscarinic_off	0	20	No	No	No	No	5	0
380	1x27	NT	muscarinic_off	0	20	No	No	No	No	0	0
381	6x49	6x53	muscarinic_off	0	0	No	No	No	No	7	7
382	5x44	Lig	muscarinic_off	0	0	No	No	Yes	Yes	8	0
383	I2x54	I2x57	muscarinic_off	0	26.6667	No	No	Yes	Yes	7	8
384	7x43	7x48	muscarinic_off	0	0	No	No	No	No	6	6
385	5x58	5x59	muscarinic_off	0	20	Yes	Yes	No	No	9	4
386	6x26	6x30	muscarinic_off	0	20	No	No	No	Yes	5	9
387	1x39	1x40	muscarinic_off	0	20	No	Yes	No	No	7	4
388	5x51	5x55	muscarinic_off	0	0	No	No	No	No	7	6
389	1x41	1x45	muscarinic_off	0	20	No	No	No	No	5	5
390	1x35	1x39	muscarinic_off	0	0	No	No	No	Yes	6	7
391	7x32	7x36	muscarinic_off	0	0	No	No	No	No	4	5
392	4x44	4x48	muscarinic_off	0	20	No	No	No	No	4	4
393	6x36	7x53	muscarinic_off	0	20	No	No	Yes	Yes	9	9
394	1x31	1x35	muscarinic_off	0	6.66667	Yes	No	No	No	5	6
395	5x65	6x31	muscarinic_off	0	20	No	No	Yes	Yes	8	7
396	6x29	6x30	muscarinic_off	0	20	No	No	No	Yes	7	9
397	1x58	2x44	muscarinic_off	0	20	No	No	No	No	5	7
398	6x32	8x48	muscarinic_off	0	20	No	No	No	No	9	5
399	5x69	6x27	muscarinic_off	0	20	No	No	No	No	5	4
400	4x69	E2	muscarinic_off	0	20	No	No	Yes	Yes	5	5
401	6x25	6x27	muscarinic_off	0	20	No	No	No	No	5	4
402	1x29	1x33	muscarinic_off	0	20	No	No	No	No	5	6
403	7x55	7x56	muscarinic_off	0	0	No	No	No	No	7	9
404	1x28	1x29	muscarinic_off	0	20	No	No	No	No	5	5
405	1x30	1x34	muscarinic_off	0	0	No	No	No	No	3	3
406	6x32	6x35	muscarinic_off	0	6.66667	No	No	No	No	9	8
407	2x67	E1x49	muscarinic_off	0	0	No	No	No	Yes	6	4
408	8x60	CT	muscarinic_off	0	0	No	No	Yes	Yes	0	0
409	8x59	8x61	muscarinic_off	0	0	No	No	No	No	0	0

Orange: nodes, hubs and links specific of muscarinic_on network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of muscarinic_off network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	muscarinic_on Avg Int. Strength	muscarinic_off Avg Int. Strength	muscarinic_on Num Of Links	muscarinic_off Num Of Links	ConSurf
1	1x31	muscarinic_on	0	0	4	3	5
2	2x65	muscarinic_on	0	0	4	3	6
3	2x66	muscarinic_on	0	0	4	3	6
4	3x37	muscarinic_on	56.25	40	4	3	9
5	3x49	muscarinic_on	50	40	4	3	9
6	4x50	muscarinic_on	0	0	4	3	9
7	4x62	muscarinic_on	0	0	4	3	6
8	5x48	muscarinic_on	25	0	5	3	8
9	5x66	muscarinic_on	0	0	5	1	7
10	6x40	muscarinic_on	0	0	4	3	9
11	6x51	muscarinic_on	75	40	5	3	8
12	6x59	muscarinic_on	16.6667	0	4	2	7
13	1x57	Shared	8.33333	0	5	4	8
14	1x60	Shared	25	20	4	4	8
15	2x40	Shared	37.5	40	4	5	9
16	2x42	Shared	50	93.3333	4	5	8
17	2x50	Shared	50	86.6667	5	4	9
18	2x57	Shared	12.5	60	5	5	9
19	2x60	Shared	77.0833	100	5	6	8
20	E1x50	Shared	91.6667	100	6	6	9
21	3x28	Shared	79.1667	93.3333	4	5	7
22	3x33	Shared	68.75	93.3333	5	4	8
23	3x51	Shared	62.5	80	5	4	9
24	I2x53	Shared	50	53.3333	4	4	9
25	I2x57	Shared	100	100	4	6	8
26	4x46	Shared	0	20	4	4	9
27	4x57	Shared	100	93.3333	5	4	8
28	E2	Shared	100	100	11	17	5
29	E2x52	Shared	8.33333	100	4	4	7
30	5x47	Shared	100	100	6	5	9
31	5x58	Shared	77.0833	0	5	4	9
32	6x31	Shared	0	0	4	4	7
33	6x44	Shared	75	86.6667	4	4	9
34	6x48	Shared	100	100	7	7	9
35	E3	Shared	68.75	100	8	7	5
36	7x34	Shared	0	100	4	4	6
37	7x38	Shared	68.75	80	6	6	7
38	7x39	Shared	75	60	6	6	9
39	7x42	Shared	100	100	7	8	9
40	7x53	Shared	91.6667	33.3333	4	4	9
41	8x50	Shared	58.3333	93.3333	4	4	9
42	Lig	Shared	100	100	11	13	0
43	CT	Shared	25	20	6	5	0
44	1x39	muscarinic_off	0	0	2	4	7
45	I1x50	muscarinic_off	37.5	80	3	5	9
46	E1x49	muscarinic_off	0	0	2	4	4
47	3x32	muscarinic_off	12.5	93.3333	3	5	9
48	3x50	muscarinic_off	0	40	3	5	9
49	3x52	muscarinic_off	0	40	2	4	6
50	3x56	muscarinic_off	0	0	3	4	7
51	5x57	muscarinic_off	0	0	3	4	8
52	6x30	muscarinic_off	0	0	2	5	9
53	7x45	muscarinic_off	29.1667	80	3	5	9
54	8x54	muscarinic_off	8.33333	20	3	4	9

Orange: nodes, hubs and links specific of muscarinic_on network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of muscarinic_off network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	muscarinic_on Recurrence	muscarinic_off Recurrence	muscarinic_on Hub1?	muscarinic_off Hub1?	muscarinic_on Hub2?	muscarinic_off Hub2?	ConSurf1	ConSurf2
1	2x61	2x65	muscarinic_on	13.1367	0	No	No	Yes	No	7	6
2	1x39	2x61	muscarinic_on	14.5218	1.60415	No	Yes	No	No	7	7
3	2x56	7x42	muscarinic_on	25.4103	0.521347	No	No	Yes	Yes	8	9
4	2x53	2x56	muscarinic_on	27.15	0.761969	No	No	No	No	8	8
5	2x46	2x50	muscarinic_on	29.7892	0	No	No	Yes	Yes	9	9
6	2x46	3x43	muscarinic_on	99.9884	0	No	No	No	No	9	9
7	3x43	7x53	muscarinic_on	100	0	No	No	Yes	Yes	9	9
8	3x50	7x53	muscarinic_on	48.453	0	No	Yes	Yes	Yes	9	9
9	3x50	5x58	muscarinic_on	48.5185	0	No	Yes	Yes	Yes	9	9
10	3x47	5x58	muscarinic_on	79.2402	0	No	No	Yes	Yes	9	9
11	I2x53	I2x57	muscarinic_on	46.4206	3.32243	Yes	Yes	Yes	Yes	9	8
12	2x38	I2x57	muscarinic_on	45.9833	1.35427	No	No	Yes	Yes	7	8
13	2x38	4x39	muscarinic_on	45.2416	0	No	No	No	No	7	5
14	2x41	4x39	muscarinic_on	40.6084	1.27715	No	No	No	No	8	5
15	1x57	2x41	muscarinic_on	39.6702	2.74247	Yes	Yes	No	No	8	8
16	8x50	I1x50	muscarinic_on	24.2583	0.410291	Yes	Yes	No	Yes	9	9
17	1x60	8x53	muscarinic_on	14.5931	0.243707	Yes	Yes	No	No	8	8
18	1x56	8x53	muscarinic_on	13.5509	4.4114	No	No	No	No	9	8
19	1x56	8x54	muscarinic_on	12.5048	4.43917	No	No	No	Yes	9	9
20	2x46	7x49	muscarinic_on	70.151	0	No	No	No	No	9	9
21	5x58	6x40	muscarinic_on	49.634	0	Yes	Yes	Yes	No	9	9
22	2x60	3x28	muscarinic_on	26.468	2.7579	Yes	Yes	Yes	Yes	8	7
23	2x60	7x38	muscarinic_on	12.9421	5.47261	Yes	Yes	Yes	Yes	8	7
24	3x28	E1x50	muscarinic_on	22.8924	6.32404	Yes	Yes	Yes	Yes	7	9
25	E2	E2x52	muscarinic_on	20.7367	1.32651	Yes	Yes	Yes	Yes	5	7
26	3x33	E2x52	muscarinic_on	20.7714	3.63401	Yes	Yes	Yes	Yes	8	7
27	3x33	Lig	muscarinic_on	16.1805	3.32552	Yes	Yes	Yes	Yes	8	0
28	5x58	6x37	muscarinic_on	25.3545	0	Yes	Yes	No	No	9	9
29	5x62	6x37	muscarinic_on	24.3566	0	No	No	No	No	8	9
30	5x62	5x66	muscarinic_on	19.3092	2.54812	No	No	Yes	No	8	7
31	E1x50	E1x51	muscarinic_on	10.6226	0	Yes	Yes	No	No	9	4
32	2x60	7x42	muscarinic_on	19.5423	5.48186	Yes	Yes	Yes	Yes	8	9
33	7x38	Lig	muscarinic_on	16.7354	3.8808	Yes	Yes	Yes	Yes	7	0
34	1x39	7x39	Shared	15.6623	20.9033	No	Yes	Yes	Yes	7	9
35	7x39	7x42	Shared	22.9579	30.2227	Yes	Yes	Yes	Yes	9	9
36	2x53	7x46	Shared	27.4062	20.9279	No	No	No	No	8	9
37	2x50	7x46	Shared	27.5507	20.9249	Yes	Yes	No	No	9	9
38	3x47	5x57	Shared	77.7106	40.0759	No	No	No	Yes	9	8
39	3x51	5x57	Shared	74.6051	22.7233	Yes	Yes	No	Yes	9	8
40	3x51	3x52	Shared	63.2504	28.381	Yes	Yes	No	Yes	9	6
41	3x52	I2x53	Shared	62.4104	58.4865	No	Yes	Yes	Yes	6	9
42	1x57	2x40	Shared	31.053	24.0344	Yes	Yes	Yes	Yes	8	9
43	2x40	8x50	Shared	28.1113	23.0596	Yes	Yes	Yes	Yes	9	9
44	1x60	I1x50	Shared	22.2952	10.4269	Yes	Yes	No	Yes	8	9
45	7x42	Lig	Shared	28.3482	31.2469	Yes	Yes	Yes	Yes	9	0
46	6x48	Lig	Shared	63.8514	75.5892	Yes	Yes	Yes	Yes	9	0
47	6x48	7x45	Shared	70.492	80.0531	Yes	Yes	No	Yes	9	9
48	7x45	7x49	Shared	71.199	52.9245	No	Yes	No	No	9	9
49	6x40	7x53	Shared	51.1251	72.0478	Yes	No	Yes	Yes	9	9
50	3x49	I2x53	Shared	13.4449	57.2217	Yes	No	Yes	Yes	9	9
51	2x42	3x49	Shared	12.8169	82.3205	Yes	Yes	Yes	No	8	9
52	5x47	6x48	Shared	11.3566	12.1576	Yes	Yes	Yes	Yes	9	9
53	1x31	1x35	muscarinic_off	0	10.5812	Yes	No	No	No	5	6
54	1x35	1x39	muscarinic_off	0	16.569	No	No	No	Yes	6	7
55	2x53	7x42	muscarinic_off	0	20.2955	No	No	Yes	Yes	8	9
56	2x50	7x49	muscarinic_off	1.25222	27.7517	Yes	Yes	No	No	9	9
57	6x40	7x49	muscarinic_off	0	75.4288	Yes	No	No	No	9	9
58	2x43	7x53	muscarinic_off	0	65.6034	No	No	Yes	Yes	8	9
59	2x40	2x43	muscarinic_off	1.09039	64.4435	Yes	Yes	No	No	9	8
60	8x50	8x54	muscarinic_off	0	12.6172	Yes	Yes	No	Yes	9	9
61	1x57	2x44	muscarinic_off	5.42113	17.2785	Yes	Yes	No	No	8	7
62	1x54	2x44	muscarinic_off	4.34422	14.4651	No	No	No	No	7	7
63	2x40	I1x50	muscarinic_off	0	18.1885	Yes	Yes	No	Yes	9	9
64	2x50	3x39	muscarinic_off	0.782153	32.376	Yes	Yes	No	No	9	9
65	2x46	3x39	muscarinic_off	0	100	No	No	No	No	9	9
66	2x46	3x42	muscarinic_off	0	99.2133	No	No	No	No	9	9
67	2x45	3x42	muscarinic_off	1.08461	98.4205	No	No	No	No	9	9
68	2x45	4x46	muscarinic_off	5.42113	95.1876	No	No	Yes	Yes	9	9
69	2x42	4x46	muscarinic_off	8.62873	92.6981	Yes	Yes	Yes	Yes	8	9
70	3x49	I2x57	muscarinic_off	1.19827	24.4077	Yes	No	Yes	Yes	9	8
71	3x39	7x45	muscarinic_off	0	72.5475	No	No	No	Yes	9	9
72	2x39	I2x57	muscarinic_off	0.893889	22.9054	No	No	Yes	Yes	9	8
73	2x42	3x45	muscarinic_off	2.17885	11.8244	Yes	Yes	No	No	8	8
74	1x54	2x51	muscarinic_off	0	11.6208	No	No	No	No	7	8
75	4x57	Lig	muscarinic_off	2.67203	32.7739	Yes	Yes	Yes	Yes	8	0
76	4x57	E2	muscarinic_off	0	24.2134	Yes	Yes	Yes	Yes	8	5
77	E1x49	E2	muscarinic_off	0	10.5195	No	Yes	Yes	Yes	4	5
78	5x43	Lig	muscarinic_off	0	22.8714	No	No	Yes	Yes	9	0
79	5x43	E2	muscarinic_off	0	22.2143	No	No	Yes	Yes	9	5
80	4x65	E2	muscarinic_off	1.74925	12.2069	No	No	Yes	Yes	7	5
81	4x65	4x66	muscarinic_off	0.967096	10.6676	No	No	No	No	7	6
82	3x37	4x57	muscarinic_off	0.760962	11.7319	Yes	No	Yes	Yes	9	8
83	3x48	3x52	muscarinic_off	0	23.4606	No	No	No	Yes	7	6
84	3x48	5x57	muscarinic_off	3.26925	22.2791	No	No	No	Yes	7	8
85	3x47	5x54	muscarinic_off	1.09232	37.6172	No	No	No	No	9	9
86	3x44	5x54	muscarinic_off	0	10.1647	No	No	No	No	7	9
87	2x39	3x50	muscarinic_off	0	21.6313	No	No	No	Yes	9	9
88	3x50	6x30	muscarinic_off	0	16.9731	No	Yes	No	Yes	9	9
89	3x45	4x45	muscarinic_off	1.09039	10.5442	No	No	No	No	8	8
90	5x47	5x51	muscarinic_off	0.907375	14.0116	Yes	Yes	No	No	9	7
91	5x54	6x41	muscarinic_off	0	25.2314	No	No	No	No	9	8
92	5x58	6x41	muscarinic_off	2.15574	20.2338	Yes	Yes	No	No	9	8
93	5x51	6x45	muscarinic_off	0	10.0383	No	No	No	No	7	7
94	6x51	Lig	muscarinic_off	1.389	11.9848	Yes	No	Yes	Yes	8	0
95	6x51	7x34	muscarinic_off	0	14.0949	Yes	No	Yes	Yes	8	6
96	2x57	7x42	muscarinic_off	9.8925	12.0157	Yes	Yes	Yes	Yes	9	9

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
2x53	2x56	Shared	6.604	4.64583	1	0	2	2
2x53	7x42	muscarinic_off	5.23933	0	1	0	2	1
2x56	3x32	Shared	10.7013	9.97083	1	1	2	1
2x56	7x42	Shared	7.03733	5.46021	1	1	2	1
2x57	7x39	Shared	6.28067	7.00229	1	1	2	2
2x57	7x42	Shared	6.386	7.03083	1	1	2	1
2x60	3x28	Shared	6.48267	4.49875	1	1	2	2
2x60	7x38	Shared	18.532	12.1015	1	1	2	1
2x60	7x39	Shared	3.69667	4.01542	1	1	2	2
2x60	7x42	Shared	6.46933	4.33292	1	1	2	1
3x28	3x32	muscarinic_off	8.188	0	0	0	2	1
3x32	7x38	muscarinic_off	4.67667	0	1	1	1	1
3x32	7x42	Shared	9.5	9.72292	1	1	1	1
3x32	Lig	Shared	4.62467	7.82125	1	1	1	0
3x33	4x57	Shared	14.018	14.6965	1	1	1	1
3x33	E2x52	Shared	9.26667	7.22646	1	1	1	2
3x33	7x38	Shared	4.10267	4.92333	1	1	1	1
3x33	Lig	Shared	19.9613	10.3421	1	1	1	0
3x36	6x48	muscarinic_off	4.77733	0	1	0	1	1
3x36	Lig	Shared	8.93133	8.34771	1	0	1	0
3x37	4x53	Shared	8.308	5.82188	0	1	1	2
3x37	4x57	Shared	9.21	8.73458	0	1	1	1
4x57	E2	muscarinic_off	4.43333	0	1	1	1	2
4x57	Lig	Shared	5.61933	10.1485	1	1	1	0
E2	E2	Shared	52.4127	32.6042	1	1	2	2
E2	E2x52	Shared	16.4447	12.4887	1	1	2	2
5x43	E2	muscarinic_off	4.86067	0	1	0	1	2
5x43	Lig	muscarinic_off	3.98	0	1	0	1	0
5x461	Lig	Shared	4.47733	2.42688	0	0	1	0
5x47	5x48	Shared	7.42667	9.04917	1	1	2	2
5x47	6x44	Shared	4.57467	4.24292	1	1	2	2
5x47	6x48	Shared	5.546	5.76292	1	1	2	1
5x47	6x52	Shared	25.214	18.4002	1	1	2	1
5x48	6x52	muscarinic_off	4.186	0	1	0	2	1
6x44	6x48	Shared	18.106	8.39375	1	1	2	1
6x44	7x45	muscarinic_off	4.66933	0	1	1	2	2
6x47	6x48	Shared	4.608	4.67292	1	1	2	1
6x47	7x45	Shared	7.99333	8.6825	1	1	2	2
6x48	7x41	Shared	13.146	9.22396	1	1	1	1
6x48	7x45	Shared	7.006	9.8875	1	1	1	2
6x48	Lig	Shared	12.672	10.671	1	1	1	0
6x51	7x34	muscarinic_off	6.62267	0	1	1	1	2
6x51	7x38	Shared	7.678	5.00625	1	1	1	1
6x51	Lig	Shared	14.524	11.3048	1	1	1	0
6x52	Lig	muscarinic_off	10.4173	0	1	0	1	0
7x38	7x42	Shared	7.61333	5.2325	1	1	1	1
7x38	Lig	Shared	15.8667	9.63354	1	1	1	0
7x39	7x42	Shared	5.07933	8.47958	1	1	2	1
7x41	Lig	Shared	6.13067	5.33646	1	1	1	0
7x42	Lig	Shared	4.47733	4.72417	1	1	1	0
3x37	3x41	Shared	3.356	5.79938	0	1	1	2
5x44	Lig	muscarinic_off	2.13733	0	0	0	1	0
3x33	6x51	muscarinic_on	0	5.16896	1	1	1	1
3x40	6x48	muscarinic_on	0	5.055	0	1	2	1
4x56	4x57	muscarinic_on	0	5.67021	0	0	2	1
4x57	5x43	muscarinic_on	0	7.90792	1	1	1	1
6x51	6x52	muscarinic_on	0	5.76562	1	1	1	1
6x51	6x55	muscarinic_on	0	6.07375	1	1	1	2
7x34	7x38	muscarinic_on	0	4.19979	1	1	2	1
3x37	Lig	muscarinic_on	0	4.80979	0	1	1	0
3x40	6x44	muscarinic_on	0	3.98688	0	1	2	2
5x44	5x48	muscarinic_on	0	1.38896	0	0	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	muscarinic_off	m2_off m3_off m4_off m5_off m1_off
	muscarinic_on	m2_on m3_on m4_on m1_on

Network Difference
Value	muscarinic_on	muscarinic_off
I_min	3.58562	3.58533
Number of Linked Nodes	274	272
Number of Specific Nodes	5 (1.82%)	3 (1.10%)
Number of Shared Nodes	269 (98.18%)	269 (98.90%)
Number of Links	307	312
Number of Specific Links	97 (31.60%)	102 (32.69%)
Number of Shared Links	210 (68.40%)	210 (67.31%)
Number of Hubs	43	42
Number of Specific Hubs	12 (27.91%)	11 (26.19%)
Number of Shared Hubs	31 (72.09%)	31 (73.81%)
Average % Shared Neighbours (Jaccard)	55.40
Average % Shared Neighbours (Otsuka)	63.11
Average % Shared Neighbours (Overlap Coefficient)	70.69
Average % Shared Cliques (k3-6)	60.14
Graphlets Similarity	0.724981

Paths Difference
Value	muscarinic_on	muscarinic_off
Number Of Nodes in MetaPath	50	60
Specific Nodes in MetaPath	19 (38.00%)	29 (48.33%)
Shared Nodes in MetaPath	269 (98.18%)	269 (98.18%)
Number Of Links MetaPath	52	63
Specific Links in MetaPath	33 (63.46%)	44 (69.84%)
Shared Links in MetaPath	210 (68.40%)	210 (68.40%)
Number of Shortest Paths	76140	68142
Length Of Smallest Path	3	3
Average Path Length	17.9167	14.7437
Length of Longest Path	41	34
Minimum Path Strength	0.323854	0.233667
Average Path Strength	6.29848	6.32654
Maximum Path Strength	14.6786	19.5423
Minimum Path Correlation	0.703125	0.700667
Average Path Correlation	0.922975	0.909722
Maximum Path Correlation	0.988333	0.988
Minimum % Of Corr. Nodes	2.7027	3.84615
Average % Of Corr. Nodes	38.1199	41.7687
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	45.4897	45.9844
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download muscarinic_off_on.zip<

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