Orange: nodes, hubs and links specific of muscarinic_on_gp network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of muscarinic_off network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.


Index Hub Owner muscarinic_on_gp Avg Int. Strength muscarinic_off Avg Int. Strength muscarinic_on_gp Num Of Links muscarinic_off Num Of Links ConSurf
11x31 muscarinic_on_gp00435
21x46 muscarinic_on_gp250428
31x50 muscarinic_on_gp250439
42x46 muscarinic_on_gp500429
52x53 muscarinic_on_gp2526.6667538
62x65 muscarinic_on_gp00436
72x66 muscarinic_on_gp00436
83x37 muscarinic_on_gp70.833340439
93x49 muscarinic_on_gp5040439
103x53 muscarinic_on_gp250428
114x50 muscarinic_on_gp250439
124x62 muscarinic_on_gp00436
134x68 muscarinic_on_gp00424
145x48 muscarinic_on_gp52.08330638
156x51 muscarinic_on_gp91.666740538
166x59 muscarinic_on_gp16.66670427
17G.HN.34 muscarinic_on_gp00403
18G.hns1.03 muscarinic_on_gp00404
19G.H1.01 muscarinic_on_gp00409
20G.S2.06 muscarinic_on_gp250508
21G.S2.08 muscarinic_on_gp37.50405
22G.S3.03 muscarinic_on_gp68.750507
23G.S3.04 muscarinic_on_gp70.83330506
24G.S3.06 muscarinic_on_gp52.08330506
25G.s3h2.03 muscarinic_on_gp37.50409
26G.H2.06 muscarinic_on_gp1000609
27G.H2.07 muscarinic_on_gp1000709
28G.h2s4.01 muscarinic_on_gp93.750509
29G.S4.03 muscarinic_on_gp250507
30G.S4.04 muscarinic_on_gp500409
31G.s4h3.04 muscarinic_on_gp43.750608
32G.s4h3.05 muscarinic_on_gp00409
33G.H3.01 muscarinic_on_gp41.66670709
34G.H3.06 muscarinic_on_gp16.66670407
35G.H3.09 muscarinic_on_gp1000609
36G.H3.13 muscarinic_on_gp250405
37G.H3.15 muscarinic_on_gp00408
38G.H3.17 muscarinic_on_gp1000704
39G.H3.18 muscarinic_on_gp33.33330409
40G.S5.03 muscarinic_on_gp250408
41G.S5.04 muscarinic_on_gp250409
42G.S5.05 muscarinic_on_gp68.750809
43G.S5.07 muscarinic_on_gp250409
44G.s5hg.01 muscarinic_on_gp16.66670409
45G.hgh4.01 muscarinic_on_gp33.33330504
46G.hgh4.02 muscarinic_on_gp750608
47G.hgh4.05 muscarinic_on_gp68.750606
48G.hgh4.08 muscarinic_on_gp00401
49G.H4.01 muscarinic_on_gp00403
50G.H4.03 muscarinic_on_gp43.750403
51G.H4.05 muscarinic_on_gp250704
52G.H4.10 muscarinic_on_gp60.41670406
53G.H4.15 muscarinic_on_gp54.16670408
54G.h4s6.01 muscarinic_on_gp00404
55G.S6.02 muscarinic_on_gp1000608
56G.S6.05 muscarinic_on_gp56.250505
57G.s6h5.01 muscarinic_on_gp62.50509
58G.s6h5.02 muscarinic_on_gp00407
59G.H5.03 muscarinic_on_gp33.33330408
60G.H5.05 muscarinic_on_gp00405
61G.H5.08 muscarinic_on_gp1000508
62G.H5.13 muscarinic_on_gp54.16670707
63b.1x1 muscarinic_on_gp00404
64b.1x4 muscarinic_on_gp00408
65b.1x15 muscarinic_on_gp00407
66b.h2x1 muscarinic_on_gp33.33330405
67b.l1x3 muscarinic_on_gp1000509
68b.b2x1 muscarinic_on_gp1000508
69b.b2x3 muscarinic_on_gp37.50406
70b.b2x5 muscarinic_on_gp1000607
71b.b3x3 muscarinic_on_gp500408
72b.l3x2 muscarinic_on_gp81.250509
73b.b4x3 muscarinic_on_gp18.750407
74b.b4x4 muscarinic_on_gp250408
75b.b4x6 muscarinic_on_gp1000509
76b.b5x2 muscarinic_on_gp00407
77b.b5x3 muscarinic_on_gp750609
78b.b5x5 muscarinic_on_gp43.750405
79b.b5x7 muscarinic_on_gp66.66670407
80b.l5x1 muscarinic_on_gp58.33330508
81b.l5x5 muscarinic_on_gp1000709
82b.b6x5 muscarinic_on_gp60.41670606
83b.l6x5 muscarinic_on_gp62.50404
84b.b7x1 muscarinic_on_gp1000504
85b.b7x4 muscarinic_on_gp00508
86b.l7x4 muscarinic_on_gp00409
87b.b8x1 muscarinic_on_gp41.66670408
88b.b8x3 muscarinic_on_gp52.08330406
89b.b8x4 muscarinic_on_gp1000606
90b.l8x3 muscarinic_on_gp00403
91b.l8x5 muscarinic_on_gp00403
92b.l9x3 muscarinic_on_gp750609
93b.l9x6 muscarinic_on_gp1000908
94b.b10x5 muscarinic_on_gp60.41670609
95b.b11x4 muscarinic_on_gp41.66670409
96b.l11x2 muscarinic_on_gp1000409
97b.b12x3 muscarinic_on_gp56.250408
98b.b12x6 muscarinic_on_gp1000608
99b.b13x7 muscarinic_on_gp1000507
100b.l13x3 muscarinic_on_gp1000709
101b.l13x6 muscarinic_on_gp31.250409
102b.l13x7 muscarinic_on_gp500509
103b.b14x3 muscarinic_on_gp45.83330405
104b.b15x1 muscarinic_on_gp750609
105b.b15x3 muscarinic_on_gp500409
106b.l15x1 muscarinic_on_gp43.750407
107b.l15x2 muscarinic_on_gp87.50509
108b.b16x4 muscarinic_on_gp1000406
109b.b16x5 muscarinic_on_gp37.50405
110b.b16x6 muscarinic_on_gp1000608
111b.b17x5 muscarinic_on_gp500407
112b.b17x7 muscarinic_on_gp1000408
113b.l17x3 muscarinic_on_gp1000609
114b.l17x6 muscarinic_on_gp68.750409
115b.b18x3 muscarinic_on_gp66.66670408
116b.b18x5 muscarinic_on_gp250405
117b.l18x1 muscarinic_on_gp1000706
118b.l18x2 muscarinic_on_gp77.08330407
119b.l18x3 muscarinic_on_gp250405
120b.b19x2 muscarinic_on_gp1000706
121b.b19x4 muscarinic_on_gp47.91670408
122b.l19x2 muscarinic_on_gp93.750509
123b.b20x4 muscarinic_on_gp1000508
124b.b20x6 muscarinic_on_gp1000606
125b.b21x1 muscarinic_on_gp43.750407
126b.b21x2 muscarinic_on_gp250406
127b.b21x5 muscarinic_on_gp00404
128b.b21x7 muscarinic_on_gp1000505
129b.b22x5 muscarinic_on_gp250507
130b.l22x5 muscarinic_on_gp68.750409
131b.b23x2 muscarinic_on_gp250406
132b.b23x6 muscarinic_on_gp1000607
133b.l23x1 muscarinic_on_gp43.750406
134b.l23x2 muscarinic_on_gp250408
135b.b24x4 muscarinic_on_gp54.16670406
136b.b24x6 muscarinic_on_gp62.50408
137b.l24x3 muscarinic_on_gp250405
138b.l25x3 muscarinic_on_gp1000509
139b.l25x6 muscarinic_on_gp81.250408
140b.l27x1 muscarinic_on_gp1000709
141b.l27x2 muscarinic_on_gp1000409
142b.b28x3 muscarinic_on_gp250407
143b.b28x4 muscarinic_on_gp1000506
144b.b28x6 muscarinic_on_gp1000409
145g.h1x10 muscarinic_on_gp250409
146g.h2x11 muscarinic_on_gp1000406
147g.ctx3 muscarinic_on_gp93.750509
148g.ctx6 muscarinic_on_gp500406
149g.ctx14 muscarinic_on_gp41.66670409
150g.ctx15 muscarinic_on_gp500409
151g.ctx16 muscarinic_on_gp1000708
1521x57 Shared16.66670448
1531x60 Shared2520448
1542x40 Shared43.7540459
1552x42 Shared68.7593.3333558
1562x50 Shared58.333386.6667549
1572x57 Shared43.7560559
1582x60 Shared91.6667100768
159E1x50 Shared91.6667100669
1603x28 Shared79.166793.3333457
1613x33 Shared68.7593.3333548
1623x50 Shared93.7540559
1633x51 Shared68.7580549
164I2x53 Shared5053.3333449
165I2x57 Shared100100468
1664x46 Shared2520449
1674x57 Shared10093.3333548
168E2 Shared10010013175
169E2x52 Shared52.0833100447
1705x47 Shared100100659
1715x58 Shared85.41670649
1726x31 Shared00447
1736x44 Shared10086.6667749
1746x48 Shared100100879
175E3 Shared75100875
1767x34 Shared20.8333100446
1777x38 Shared10080667
1787x39 Shared93.7560669
1797x42 Shared100100889
1807x45 Shared43.7580459
1817x53 Shared10033.3333549
1828x50 Shared83.333393.3333549
183Lig Shared10010011130
184CT Shared2520750
1851x39 muscarinic_off00247
186I1x50 muscarinic_off5080359
187E1x49 muscarinic_off00244
1883x32 muscarinic_off18.7593.3333359
1893x52 muscarinic_off040246
1903x56 muscarinic_off00247
1915x57 muscarinic_off00348
1926x30 muscarinic_off00259
1938x54 muscarinic_off8.3333320349
   
Orange: nodes, hubs and links specific of muscarinic_on_gp network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of muscarinic_off network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Owner muscarinic_on_gp Recurrence muscarinic_off Recurrence muscarinic_on_gp Hub1? muscarinic_off Hub1? muscarinic_on_gp Hub2? muscarinic_off Hub2? ConSurf1 ConSurf2
16x44 6x48 muscarinic_on_gp35.60240.922384YesYesYesYes99
23x43 6x44 muscarinic_on_gp41.79691.03961NoNoYesYes99
33x43 7x53 muscarinic_on_gp48.34880NoNoYesYes99
43x46 7x53 muscarinic_on_gp53.88020NoNoYesYes99
52x42 3x46 muscarinic_on_gp64.36721.32651YesYesNoNo89
62x39 3x49 muscarinic_on_gp84.11530NoNoYesNo99
72x39 G.H5.22 muscarinic_on_gp92.75210NoNoNoNo94
88x47 G.H5.22 muscarinic_on_gp92.97150NoNoNoNo94
98x47 8x50 muscarinic_on_gp46.81739.91486NoNoYesYes99
108x47 8x49 muscarinic_on_gp46.37580.240622NoNoNoNo97
118x49 I1x50 muscarinic_on_gp46.47431.64116NoNoNoYes79
128x50 I1x50 muscarinic_on_gp47.90920.410291YesYesNoYes99
131x60 CT muscarinic_on_gp95.65317.72767YesYesYesYes80
14CT b.l23x2 muscarinic_on_gp96.03380YesYesYesNo08
15b.l21x7 b.l23x2 muscarinic_on_gp99.86920NoNoYesNo58
16b.l21x7 b.l23x1 muscarinic_on_gp1000NoNoYesNo56
172x46 2x50 muscarinic_on_gp11.69980YesNoYesYes99
18b.l23x1 b.l25x6 muscarinic_on_gp98.40520YesNoYesNo68
19G.H3.17 b.l25x6 muscarinic_on_gp34.57420YesNoYesNo48
20G.H2.08 G.H3.17 muscarinic_on_gp21.26120NoNoYesNo84
21G.H2.08 G.H3.18 muscarinic_on_gp21.24490NoNoYesNo89
22G.H3.18 G.S4.02 muscarinic_on_gp42.31880YesNoNoNo97
23G.S1.05 G.S4.02 muscarinic_on_gp42.28750NoNoNoNo97
24G.S1.05 G.S1.07 muscarinic_on_gp56.2020NoNoNoNo99
25G.S1.07 G.S4.04 muscarinic_on_gp55.86570NoNoYesNo99
26G.H3.09 G.S4.04 muscarinic_on_gp55.56350YesNoYesNo99
27G.H3.09 G.S5.04 muscarinic_on_gp26.67520YesNoYesNo99
28G.S5.04 G.S5.06 muscarinic_on_gp26.03040YesNoNoNo98
29G.S5.06 G.s4h3.01 muscarinic_on_gp20.68980NoNoNoNo87
30G.HG.04 G.s4h3.01 muscarinic_on_gp20.51790NoNoNoNo87
31G.HG.04 G.s4h3.04 muscarinic_on_gp20.00580NoNoYesNo88
32G.HG.07 G.s4h3.04 muscarinic_on_gp17.41970NoNoYesNo98
33G.HG.07 G.s4h3.02 muscarinic_on_gp17.47550NoNoNoNo99
34G.s4h3.02 G.s5hg.01 muscarinic_on_gp16.91570NoNoYesNo99
35G.S5.07 G.s5hg.01 muscarinic_on_gp16.61460YesNoYesNo99
36G.S5.07 G.s6h5.01 muscarinic_on_gp15.30870YesNoYesNo99
37G.S5.05 G.s6h5.01 muscarinic_on_gp14.18370YesNoYesNo99
38G.H3.15 G.H3.17 muscarinic_on_gp21.25410YesNoYesNo84
39G.H3.15 G.H3.18 muscarinic_on_gp21.28770YesNoYesNo89
405x62 6x37 muscarinic_on_gp10.30390NoNoNoNo89
41b.l25x6 b.l27x1 muscarinic_on_gp69.22050YesNoYesNo89
42b.b26x1 b.l27x1 muscarinic_on_gp35.7660NoNoYesNo99
43b.b26x1 b.b26x2 muscarinic_on_gp35.61060NoNoNoNo97
44b.b26x2 b.b2x3 muscarinic_on_gp35.45570NoNoYesNo76
45b.b2x3 b.b2x5 muscarinic_on_gp25.8510YesNoYesNo67
46b.b2x5 b.l4x1 muscarinic_on_gp22.10030YesNoNoNo75
47b.l4x1 g.ctx16 muscarinic_on_gp21.94570NoNoYesNo58
48b.l4x2 g.ctx16 muscarinic_on_gp17.41480NoNoYesNo48
49b.l2x5 b.l4x2 muscarinic_on_gp18.21180NoNoNoNo54
50b.l2x3 b.l2x5 muscarinic_on_gp18.01070NoNoNoNo85
51b.b3x1 b.l2x3 muscarinic_on_gp17.84090NoNoNoNo58
52b.b3x1 b.b6x5 muscarinic_on_gp17.6710NoNoYesNo56
53b.b2x1 b.l27x1 muscarinic_on_gp78.51550YesNoYesNo89
54b.b2x1 b.l3x1 muscarinic_on_gp78.83230YesNoNoNo89
55b.l3x1 b.l5x5 muscarinic_on_gp78.93340NoNoYesNo99
56G.h2s4.01 b.l5x5 muscarinic_on_gp40.91110YesNoYesNo99
57G.H3.01 G.s4h3.05 muscarinic_on_gp14.66620YesNoYesNo99
58G.H3.09 G.H4.15 muscarinic_on_gp13.29840YesNoYesNo98
59G.H3.06 G.H4.15 muscarinic_on_gp12.91530YesNoYesNo78
60G.H3.06 G.H4.14 muscarinic_on_gp12.47290YesNoNoNo76
61G.hgh4.01 G.hgh4.02 muscarinic_on_gp10.79130YesNoYesNo48
62G.hgh4.01 G.s4h3.05 muscarinic_on_gp13.79140YesNoYesNo49
63G.H3.09 G.h4s6.01 muscarinic_on_gp14.020YesNoYesNo94
64G.H3.06 G.h4s6.01 muscarinic_on_gp13.09090YesNoYesNo74
65G.H3.03 G.H3.06 muscarinic_on_gp13.22170NoNoYesNo47
66G.H2.07 G.h2s4.01 muscarinic_on_gp47.3250YesNoYesNo99
67b.l5x5 b.l7x2 muscarinic_on_gp36.74420YesNoNoNo99
68G.H2.07 b.l7x2 muscarinic_on_gp36.71130YesNoNoNo99
69G.H2.07 b.l9x6 muscarinic_on_gp82.86080YesNoYesNo98
70G.H2.06 b.l9x6 muscarinic_on_gp75.85960YesNoYesNo98
71G.H2.06 b.l17x6 muscarinic_on_gp37.76390YesNoYesNo99
72G.H2.06 b.b18x1 muscarinic_on_gp37.7640YesNoNoNo99
73b.l17x6 b.l19x1 muscarinic_on_gp38.38530YesNoNoNo99
74b.l17x5 b.l19x1 muscarinic_on_gp75.7280NoNoNoNo69
75b.l17x5 b.l19x2 muscarinic_on_gp75.44140NoNoYesNo69
76b.l17x3 b.l19x2 muscarinic_on_gp51.91540YesNoYesNo99
77b.b19x4 b.l17x3 muscarinic_on_gp28.67740YesNoYesNo89
78b.b19x4 b.b20x6 muscarinic_on_gp21.1750YesNoYesNo86
79b.b17x7 b.b20x6 muscarinic_on_gp48.1790YesNoYesNo86
80b.b17x7 b.b21x1 muscarinic_on_gp39.18930YesNoYesNo87
81b.1x19 b.b21x1 muscarinic_on_gp36.51420NoNoYesNo67
82b.1x15 b.1x19 muscarinic_on_gp32.06480YesNoNoNo76
83b.1x11 b.1x15 muscarinic_on_gp24.84610NoNoYesNo87
84b.1x11 g.h1x12 muscarinic_on_gp22.13730NoNoNoNo86
85b.1x10 g.h1x12 muscarinic_on_gp21.23420NoNoNoNo16
86b.1x10 b.1x7 muscarinic_on_gp18.52410NoNoNoNo18
87b.1x7 g.h1x8 muscarinic_on_gp17.62050NoNoNoNo87
88b.b18x1 b.l19x1 muscarinic_on_gp37.62910NoNoNoNo99
89b.b20x4 b.l17x3 muscarinic_on_gp22.06550YesNoYesNo89
90b.b20x4 b.b20x6 muscarinic_on_gp42.32990YesNoYesNo86
91b.b20x2 b.l19x2 muscarinic_on_gp22.65370NoNoYesNo69
92b.b20x2 b.b20x4 muscarinic_on_gp22.06150NoNoYesNo68
93b.b23x6 b.l23x2 muscarinic_on_gp11.81510YesNoYesNo78
94b.b2x4 b.b6x5 muscarinic_on_gp10.78680NoNoYesNo66
95b.b10x4 b.b2x4 muscarinic_on_gp10.61240NoNoNoNo66
96b.b19x2 b.b20x6 muscarinic_on_gp13.5320YesNoYesNo66
977x38 Lig muscarinic_on_gp10.09863.8808YesYesYesYes70
983x46 3x50 muscarinic_on_gp10.26110NoNoYesYes99
99G.S1.05 G.h2s4.01 muscarinic_on_gp14.59250NoNoYesNo99
1007x42 Lig Shared13.494331.2469YesYesYesYes90
1016x48 Lig Shared32.84775.5892YesYesYesYes90
1022x42 3x49 Shared77.308882.3205YesYesYesNo89
1031x60 I1x50 Shared94.457510.4269YesYesNoYes89
1042x45 4x46 Shared11.401895.1876NoNoYesYes99
1053x51 3x52 Shared10.631328.381YesYesNoYes96
1063x52 I2x53 Shared11.102458.4865NoYesYesYes69
1072x42 4x46 Shared12.096792.6981YesYesYesYes89
1081x31 1x35 muscarinic_off010.5812YesNoNoNo56
1091x35 1x39 muscarinic_off016.569NoNoNoYes67
1101x39 7x39 muscarinic_off2.9910320.9033NoYesYesYes79
1117x39 7x42 muscarinic_off4.9240530.2227YesYesYesYes99
1122x53 7x42 muscarinic_off0.095235520.2955YesNoYesYes89
1132x53 7x46 muscarinic_off3.9316120.9279YesNoNoNo89
1142x50 7x46 muscarinic_off4.4094120.9249YesYesNoNo99
1152x50 7x49 muscarinic_off0.035868627.7517YesYesNoNo99
1166x40 7x49 muscarinic_off075.4288NoNoNoNo99
1176x40 7x53 muscarinic_off1.0170272.0478NoNoYesYes99
1182x43 7x53 muscarinic_off065.6034NoNoYesYes89
1192x40 2x43 muscarinic_off0.141864.4435YesYesNoNo98
1202x40 8x50 muscarinic_off1.554423.0596YesYesYesYes99
1218x50 8x54 muscarinic_off012.6172YesYesNoYes99
1226x48 7x45 muscarinic_off0.034464180.0531YesYesYesYes99
1237x45 7x49 muscarinic_off0.049319452.9245YesYesNoNo99
1241x57 2x40 muscarinic_off1.1317524.0344YesYesYesYes89
1251x57 2x44 muscarinic_off0.70813517.2785YesYesNoNo87
1261x54 2x44 muscarinic_off0.56671314.4651NoNoNoNo77
1272x40 I1x50 muscarinic_off018.1885YesYesNoYes99
1282x50 3x39 muscarinic_off0.50270132.376YesYesNoNo99
1292x46 3x39 muscarinic_off0100YesNoNoNo99
1302x46 3x42 muscarinic_off6.3484299.2133YesNoNoNo99
1312x45 3x42 muscarinic_off6.5436598.4205NoNoNoNo99
1323x49 I2x57 muscarinic_off0.11981424.4077YesNoYesYes98
1333x39 7x45 muscarinic_off072.5475NoNoYesYes99
1342x39 I2x57 muscarinic_off8.4171922.9054NoNoYesYes98
1352x42 3x45 muscarinic_off0.52004111.8244YesYesNoNo88
1361x54 2x51 muscarinic_off011.6208NoNoNoNo78
1374x57 Lig muscarinic_off1.0172332.7739YesYesYesYes80
1384x57 E2 muscarinic_off024.2134YesYesYesYes85
139E1x49 E2 muscarinic_off010.5195NoYesYesYes45
1405x43 Lig muscarinic_off022.8714NoNoYesYes90
1415x43 E2 muscarinic_off022.2143NoNoYesYes95
1424x65 E2 muscarinic_off0.51463912.2069NoNoYesYes75
1434x65 4x66 muscarinic_off0.25767110.6676NoNoNoNo76
1443x37 4x57 muscarinic_off1.0016711.7319YesNoYesYes98
1453x49 I2x53 muscarinic_off6.7661557.2217YesNoYesYes99
1463x48 3x52 muscarinic_off023.4606NoNoNoYes76
1473x48 5x57 muscarinic_off2.428822.2791NoNoNoYes78
1483x47 5x57 muscarinic_off1.2188340.0759NoNoNoYes98
1493x47 5x54 muscarinic_off1.3518337.6172NoNoNoNo99
1503x44 5x54 muscarinic_off010.1647NoNoNoNo79
1513x51 5x57 muscarinic_off4.0857822.7233YesYesNoYes98
1522x39 3x50 muscarinic_off021.6313NoNoYesYes99
1533x50 6x30 muscarinic_off016.9731YesYesNoYes99
1543x45 4x45 muscarinic_off0.26004810.5442NoNoNoNo88
1555x47 6x48 muscarinic_off0.095505612.1576YesYesYesYes99
1565x47 5x51 muscarinic_off0.026469314.0116YesYesNoNo97
1575x54 6x41 muscarinic_off025.2314NoNoNoNo98
1585x58 6x41 muscarinic_off1.0172320.2338YesYesNoNo98
1595x51 6x45 muscarinic_off0.26971710.0383NoNoNoNo77
1606x51 Lig muscarinic_off0.52268811.9848YesNoYesYes80
1616x51 7x34 muscarinic_off014.0949YesNoYesYes86
1622x57 7x42 muscarinic_off1.0808712.0157YesYesYesYes99

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Midway



Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Node1Node2OwnerNet1LinkStrengthNet2LinkStrengthComm1Comm2Node1ShellNode2Shell
2x532x56Shared6.6044.645831122
2x537x42Shared5.239333.301461121
2x563x32Shared10.70139.970831121
2x567x42Shared7.037335.460211121
2x577x39Shared6.280677.002291122
2x577x42Shared6.3867.030831121
2x603x28Shared6.482674.498751122
2x607x38Shared18.53212.10151121
2x607x39Shared3.696674.015421122
2x607x42Shared6.469334.332921121
3x283x32muscarinic_off8.18800021
3x327x38muscarinic_off4.6766701111
3x327x42Shared9.59.722921111
3x32LigShared4.624677.821251110
3x334x57Shared14.01814.69651111
3x33E2x52Shared9.266677.226461112
3x337x38Shared4.102674.923331111
3x33LigShared19.961310.34211110
3x366x48Shared4.777333.218541111
3x36LigShared8.931338.347711110
3x374x53Shared8.3085.821880112
3x374x57Shared9.218.734580111
4x57E2muscarinic_off4.4333301112
4x57LigShared5.6193310.14851110
E2E2Shared52.412732.60421122
E2E2x52Shared16.444712.48871122
5x43E2muscarinic_off4.8606701012
5x43Ligmuscarinic_off3.9801010
5x461LigShared4.477332.426880010
5x475x48Shared7.426679.049171122
5x476x44Shared4.574674.242921122
5x476x48Shared5.5465.762921121
5x476x52Shared25.21418.40021121
5x486x52Shared4.1862.906871121
6x446x48Shared18.1068.393751121
6x447x45Shared4.669332.970211122
6x476x48Shared4.6084.672921121
6x477x45Shared7.993338.68251122
6x487x41Shared13.1469.223961111
6x487x45Shared7.0069.88751112
6x48LigShared12.67210.6711110
6x517x34muscarinic_off6.6226701112
6x517x38Shared7.6785.006251111
6x51LigShared14.52411.30481110
6x52Ligmuscarinic_off10.417301110
7x387x42Shared7.613335.23251111
7x38LigShared15.86679.633541110
7x397x42Shared5.079338.479581121
7x41LigShared6.130675.336461110
7x42LigShared4.477334.724171110
3x373x41Shared3.3565.799380112
5x44Ligmuscarinic_off2.1373300010
2x533x36muscarinic_on_gp03.513541121
3x336x51muscarinic_on_gp05.168961111
3x406x48muscarinic_on_gp05.0550121
4x564x57muscarinic_on_gp05.670210021
4x575x43muscarinic_on_gp07.907921111
6x516x52muscarinic_on_gp05.765621111
6x516x55muscarinic_on_gp06.073751112
7x347x38muscarinic_on_gp04.199791121
3x37Ligmuscarinic_on_gp04.809790110
3x406x44muscarinic_on_gp03.986880122
5x445x48muscarinic_on_gp01.388960012

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
Id Description
muscarinic_on_gp m2_on_gp
m3_on_gp
m4_on_gp
m1_on_gp
muscarinic_off m2_off
m3_off
m4_off
m5_off
m1_off
Network Difference
Value muscarinic_on_gp muscarinic_off
Imin 2.79333 3.58533
Number of Linked Nodes 926 272
Number of Specific Nodes 657 (70.95%) 3  (1.10%)
Number of Shared Nodes 269 (29.05%) 269  (98.90%)
Number of Links 1129 312
Number of Specific Links 911 (80.69%) 94  (30.13%)
Number of Shared Links 218 (19.31%) 218  (69.87%)
Number of Hubs 184 42
Number of Specific Hubs 151 (82.07%) 9  (21.43%)
Number of Shared Hubs 33 (17.93%) 33  (78.57%)
Average % Shared Neighbours (Jaccard) 16.21
Average % Shared Neighbours (Otsuka) 18.61
Average % Shared Neighbours (Overlap Coefficient) 21.07
Average % Shared Cliques (k3-6) 53.86
Graphlets Similarity 0.722909
Paths Difference
Value muscarinic_on_gp muscarinic_off
Number Of Nodes in MetaPath 104 60
Specific Nodes in MetaPath 86 (82.69%) 42  (70.00%)
Shared Nodes in MetaPath 269 (29.05%) 269  (29.05%)
Number Of Links MetaPath 107 63
Specific Links in MetaPath 99 (92.52%) 55  (87.30%)
Shared Links in MetaPath 218 (19.31%) 218  (19.31%)
Number of Shortest Paths 2960822 68142
Length Of Smallest Path 3 3
Average Path Length 32.9581 14.7437
Length of Longest Path 60 34
Minimum Path Strength 0.323854 0.233667
Average Path Strength 6.05867 6.32654
Maximum Path Strength 20.8776 19.5423
Minimum Path Correlation 0.700833 0.700667
Average Path Correlation 0.981333 0.909722
Maximum Path Correlation 1 0.988
Minimum % Of Corr. Nodes 1.92308 3.84615
Average % Of Corr. Nodes 32.7374 41.7687
Maximum % Of Corr. Nodes 100 100
Minimum Path Hubs % 0 0
Average Path Hubs % 55.8352 45.9844
Maximum Path Hubs % 100 100

Details about the values in these tables can be found in the corresponding documentation page .

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download muscarinic_off_on_gp.zip<



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