psnGPCR

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Orange: nodes, hubs and links specific of neurotensin_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of neurotensin_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	neurotensin_off Int. Strength	neurotensin_on Int. Strength	neurotensin_off Hub1?	neurotensin_on Hub1?	neurotensin_off Hub2?	neurotensin_on Hub2?	ConSurf1	ConSurf2
1	1x30	1x34	neurotensin_off	4.69	0	No	No	No	No	2	5
2	1x32	2x66	neurotensin_off	13.92	0	No	No	Yes	No	5	5
3	1x32	E1	neurotensin_off	5.24	0	No	No	No	No	5	4
4	1x36	2x61	neurotensin_off	4.42	0	No	No	No	No	6	6
5	1x39	2x57	neurotensin_off	8.38	0	Yes	Yes	Yes	No	7	8
6	1x39	7x42	neurotensin_off	8.94	0	Yes	Yes	Yes	Yes	7	7
7	1x45	7x47	neurotensin_off	3.17	0	No	No	No	No	6	7
8	1x52	1x56	neurotensin_off	4.76	0	Yes	No	Yes	No	6	7
9	1x52	8x58	neurotensin_off	4.47	0	Yes	No	No	No	6	7
10	1x54	2x47	neurotensin_off	3.15	0	No	No	No	No	8	9
11	1x56	8x57	neurotensin_off	4.71	0	Yes	No	Yes	No	7	5
12	1x59	8x53	neurotensin_off	13.78	0	No	No	No	No	5	6
13	1x59	8x57	neurotensin_off	6.47	0	No	No	Yes	No	5	5
14	2x41	4x43	neurotensin_off	5.97	0	Yes	No	No	No	5	3
15	2x45	4x46	neurotensin_off	3.1	0	No	No	No	No	9	7
16	2x49	3x35	neurotensin_off	3.44	0	Yes	No	No	No	8	7
17	2x49	3x38	neurotensin_off	3.42	0	Yes	No	No	No	8	7
18	2x49	4x50	neurotensin_off	3.71	0	Yes	No	Yes	Yes	8	9
19	2x49	Na1	neurotensin_off	5.94	0	Yes	No	No	No	8	0
20	2x50	Na1	neurotensin_off	10.73	0	No	Yes	No	No	9	0
21	2x53	7x41	neurotensin_off	3.89	0	No	No	Yes	No	7	7
22	2x59	E1x52	neurotensin_off	3.93	0	No	No	Yes	No	6	7
23	2x60	2x65	neurotensin_off	4.1	0	Yes	Yes	No	No	6	4
24	2x60	3x32	neurotensin_off	4.65	0	Yes	Yes	No	Yes	6	7
25	2x62	E1x52	neurotensin_off	6.19	0	Yes	No	Yes	No	5	7
26	2x63	2x67	neurotensin_off	2.96	0	Yes	Yes	No	No	5	5
27	2x64	3x28	neurotensin_off	7.22	0	No	Yes	Yes	Yes	4	6
28	E1	E2	neurotensin_off	7.33	0	No	No	Yes	Yes	4	3
29	E1x50	E1x52	neurotensin_off	12.03	0	Yes	Yes	Yes	No	8	7
30	3x25	E1x50	neurotensin_off	3.92	0	No	No	Yes	Yes	9	8
31	3x21	E2	neurotensin_off	3.27	0	No	No	Yes	Yes	8	3
32	3x22	3x26	neurotensin_off	10.72	0	No	No	No	No	3	7
33	3x29	4x61	neurotensin_off	3.59	0	No	Yes	No	No	4	5
34	3x31	3x35	neurotensin_off	3.17	0	No	No	No	No	5	7
35	3x32	7x41	neurotensin_off	17.1	0	No	Yes	Yes	No	7	7
36	3x36	5x461	neurotensin_off	3.2	0	No	No	Yes	No	7	6
37	3x39	Na1	neurotensin_off	8.74	0	No	No	No	No	9	0
38	3x44	5x54	neurotensin_off	3.25	0	No	No	No	No	8	8
39	3x45	4x45	neurotensin_off	5.28	0	No	No	No	No	7	6
40	3x45	4x49	neurotensin_off	3.1	0	No	No	Yes	No	7	7
41	3x46	6x37	neurotensin_off	2.98	0	No	No	No	Yes	9	8
42	3x47	5x54	neurotensin_off	6.19	0	No	No	No	No	9	8
43	3x49	3x50	neurotensin_off	13.96	0	Yes	No	Yes	No	8	9
44	3x49	I2x57	neurotensin_off	10.83	0	Yes	No	No	No	8	7
45	3x50	6x33	neurotensin_off	8.77	0	Yes	No	No	No	9	8
46	3x50	6x34	neurotensin_off	3.88	0	Yes	No	No	No	9	7
47	3x50	6x37	neurotensin_off	5.23	0	Yes	No	No	Yes	9	8
48	3x51	3x52	neurotensin_off	3.52	0	Yes	No	Yes	No	8	4
49	3x51	3x56	neurotensin_off	4.36	0	Yes	No	Yes	No	8	6
50	3x51	5x61	neurotensin_off	3.59	0	Yes	No	No	No	8	9
51	3x52	3x56	neurotensin_off	5.14	0	Yes	No	Yes	No	4	6
52	3x52	I2x57	neurotensin_off	4.24	0	Yes	No	No	No	4	7
53	3x54	3x55	neurotensin_off	3.27	0	No	No	Yes	No	9	7
54	3x54	5x61	neurotensin_off	4.37	0	No	No	No	No	9	9
55	3x54	6x34	neurotensin_off	6.08	0	No	No	No	No	9	7
56	I2x52	I2x55	neurotensin_off	4.5	0	No	No	No	No	4	4
57	I2x52	I2x56	neurotensin_off	7.05	0	No	No	No	No	4	4
58	4x41	4x44	neurotensin_off	3.71	0	No	No	No	No	5	4
59	4x42	4x46	neurotensin_off	3.04	0	No	No	No	No	7	7
60	4x59	4x62	neurotensin_off	2.98	0	No	Yes	No	No	5	5
61	4x61	4x64	neurotensin_off	7.53	0	No	No	Yes	No	5	5
62	4x64	4x65	neurotensin_off	4.52	0	Yes	No	No	No	5	6
63	4x64	E2	neurotensin_off	3.04	0	Yes	No	Yes	Yes	5	3
64	5x36	E2	neurotensin_off	3.07	0	No	No	Yes	Yes	5	3
65	5x40	Lig	neurotensin_off	4.65	0	No	No	Yes	Yes	6	0
66	5x41	6x59	neurotensin_off	7.63	0	No	No	Yes	No	5	3
67	5x43	5x461	neurotensin_off	7.45	0	No	No	Yes	No	6	6
68	5x461	6x52	neurotensin_off	4.18	0	Yes	No	No	No	6	7
69	5x47	6x44	neurotensin_off	4.29	0	Yes	Yes	No	Yes	8	9
70	5x54	6x41	neurotensin_off	3.07	0	No	No	No	No	8	8
71	5x58	5x61	neurotensin_off	8.38	0	Yes	Yes	No	No	9	9
72	5x58	6x38	neurotensin_off	11.72	0	Yes	Yes	No	Yes	9	5
73	5x60	5x64	neurotensin_off	6.07	0	No	No	No	No	5	5
74	5x63	5x64	neurotensin_off	3.64	0	No	No	No	No	4	5
75	5x65	6x31	neurotensin_off	4.86	0	No	No	No	No	8	5
76	5x67	5x68	neurotensin_off	3.23	0	No	No	No	No	4	6
77	5x68	5x71	neurotensin_off	4.47	0	No	No	No	No	6	7
78	5x70	6x27	neurotensin_off	5.43	0	No	No	No	No	4	3
79	5x71	6x27	neurotensin_off	5.43	0	No	No	No	No	7	3
80	5x71	6x31	neurotensin_off	4.86	0	No	No	No	No	7	5
81	5x74	5x76	neurotensin_off	5.75	0	No	No	No	No	5	2
82	5x75	5x76	neurotensin_off	3.49	0	No	No	No	No	4	2
83	6x28	6x29	neurotensin_off	3.62	0	No	No	No	No	5	6
84	6x29	6x32	neurotensin_off	4.82	0	No	No	No	No	6	8
85	6x40	7x49	neurotensin_off	2.96	0	No	No	Yes	No	8	9
86	6x54	7x38	neurotensin_off	6.03	0	Yes	Yes	No	No	5	6
87	6x54	Lig	neurotensin_off	12.67	0	Yes	Yes	Yes	Yes	5	0
88	6x57	6x61	neurotensin_off	4.37	0	Yes	No	No	No	4	3
89	6x57	7x33	neurotensin_off	7.46	0	Yes	No	No	Yes	4	4
90	6x57	Lig	neurotensin_off	8.29	0	Yes	No	Yes	Yes	4	0
91	6x59	6x60	neurotensin_off	4.03	0	Yes	No	No	No	3	5
92	7x27	E3	neurotensin_off	5.79	0	No	No	No	Yes	2	3
93	7x26	7x30	neurotensin_off	4.69	0	No	No	Yes	Yes	1	4
94	7x28	7x32	neurotensin_off	3.45	0	No	No	No	No	1	1
95	7x29	7x30	neurotensin_off	6.19	0	No	No	Yes	Yes	4	4
96	7x31	7x32	neurotensin_off	3.27	0	No	Yes	No	No	4	1
97	7x31	7x35	neurotensin_off	6.57	0	No	Yes	No	No	4	3
98	7x49	7x50	neurotensin_off	3.26	0	Yes	No	Yes	No	9	9
99	7x49	7x53	neurotensin_off	9.3	0	Yes	No	Yes	No	9	9
100	7x53	8x50	neurotensin_off	10.32	0	Yes	No	Yes	Yes	9	8
101	8x51	8x55	neurotensin_off	4.86	0	No	No	No	No	9	4
102	5x44	6x56	neurotensin_off	2.95	0	No	No	No	No	6	6
103	6x38	6x42	neurotensin_off	2.85	0	No	Yes	No	No	5	5
104	3x42	4x49	neurotensin_off	2.83	0	No	No	Yes	No	8	7
105	3x55	5x64	neurotensin_off	2.79	0	Yes	No	No	No	7	5
106	3x40	6x44	neurotensin_off	2.77	0	No	No	No	Yes	8	9
107	3x50	3x53	neurotensin_off	2.77	0	Yes	No	No	No	9	8
108	2x62	E1x51	neurotensin_off	2.67	0	Yes	No	No	No	5	3
109	1x33	2x66	neurotensin_off	2.45	0	No	No	Yes	No	6	5
110	1x43	2x55	neurotensin_off	2.44	0	No	No	No	No	7	5
111	7x25	7x26	neurotensin_off	2.44	0	No	No	No	No	2	1
112	6x36	7x53	neurotensin_off	2.34	0	No	No	Yes	No	8	9
113	5x76	6x28	neurotensin_off	2.33	0	No	No	No	No	2	5
114	7x27	7x28	neurotensin_off	2.3	0	No	No	No	No	2	1
115	2x52	4x50	neurotensin_off	2.28	0	No	No	Yes	Yes	8	9
116	3x23	3x24	neurotensin_off	1.95	0	No	No	No	No	1	6
117	5x72	5x73	neurotensin_off	1.86	0	No	No	No	No	5	4
118	1x46	2x54	neurotensin_off	1.71	0	No	No	No	No	8	7
119	5x70	5x73	neurotensin_off	1.71	0	No	No	No	No	4	4
120	I2x53	I2x57	neurotensin_off	1.61	0	No	No	No	No	6	7
121	3x43	6x41	neurotensin_off	1.6	0	No	No	No	No	8	8
122	2x56	3x31	neurotensin_off	1.58	0	No	No	No	No	7	5
123	3x53	6x30	neurotensin_off	1.58	0	No	No	No	No	8	7
124	1x45	7x51	neurotensin_off	1.54	0	No	No	No	No	6	6
125	3x33	4x57	neurotensin_off	1.54	0	No	No	No	No	5	7
126	1x31	1x32	neurotensin_off	1.53	0	No	No	No	No	3	5
127	5x74	6x26	neurotensin_off	1.53	0	No	No	No	No	5	4
128	5x44	5x48	neurotensin_off	1.52	0	No	No	No	No	6	5
129	6x53	6x57	neurotensin_off	1.52	0	No	No	Yes	No	5	4
130	5x33	5x37	neurotensin_off	1.5	0	No	No	No	No	4	4
131	5x72	6x30	neurotensin_off	1.5	0	No	No	No	No	5	7
132	7x36	7x40	neurotensin_off	1.49	0	No	No	No	No	6	7
133	1x36	1x40	neurotensin_off	1.47	0	No	No	No	No	6	5
134	5x59	5x60	neurotensin_off	1.47	0	No	No	No	No	3	5
135	8x48	8x52	neurotensin_off	1.46	0	No	No	No	No	4	4
136	5x62	5x66	neurotensin_off	1.45	0	No	No	No	No	6	5
137	7x51	7x55	neurotensin_off	1.43	0	No	No	No	No	6	6
138	7x48	7x49	neurotensin_off	1.42	0	No	No	Yes	No	6	9
139	1x59	8x56	neurotensin_off	1.38	0	No	No	No	No	5	4
140	5x32	5x35	neurotensin_off	1.37	0	No	No	No	No	4	4
141	1x51	1x55	neurotensin_off	1.3	0	No	No	No	No	4	4
142	1x30	1x33	neurotensin_off	1.26	0	No	No	No	No	2	6
143	1x38	1x39	neurotensin_off	1.26	0	No	No	Yes	Yes	4	7
144	1x35	1x39	Shared	5.05	4.415	No	No	Yes	Yes	5	7
145	1x36	2x66	Shared	9.7	6.67	No	No	Yes	No	6	5
146	1x39	2x60	Shared	6.73	3.365	Yes	Yes	Yes	Yes	7	6
147	1x39	2x61	Shared	4.69	2.93	Yes	Yes	No	No	7	6
148	1x42	7x43	Shared	2.98	4.47	No	No	No	No	7	5
149	1x43	1x47	Shared	7.78	3.24	No	No	No	No	7	6
150	1x46	7x47	Shared	3.64	2.795	No	No	No	No	8	7
151	1x49	7x50	Shared	4.06	4.06	No	No	Yes	No	9	9
152	1x50	2x47	Shared	4.69	3.125	Yes	Yes	No	No	9	9
153	1x50	2x50	Shared	12.12	4.04	Yes	Yes	No	Yes	9	9
154	1x50	2x51	Shared	4.12	6.18	Yes	Yes	No	No	9	7
155	1x50	7x50	Shared	6.52	5.705	Yes	Yes	Yes	No	9	9
156	1x52	8x54	Shared	10.49	4.59	Yes	No	Yes	Yes	6	7
157	1x52	8x57	Shared	3.17	1.585	Yes	No	Yes	No	6	5
158	1x53	7x50	Shared	3.5	2.625	No	No	Yes	No	9	9
159	1x56	8x50	Shared	3.89	5.835	Yes	No	Yes	Yes	7	8
160	1x56	8x53	Shared	3.04	2.315	Yes	No	No	No	7	6
161	1x56	8x54	Shared	5.19	5.185	Yes	No	Yes	Yes	7	7
162	1x57	2x40	Shared	7.71	2.57	No	No	No	No	7	8
163	2x37	2x41	Shared	3.82	5.72	No	No	Yes	No	8	5
164	2x37	4x39	Shared	5.27	9.225	No	No	No	Yes	8	3
165	2x38	3x49	Shared	4.23	5.645	No	Yes	Yes	No	7	8
166	2x41	4x39	Shared	7.2	5.66	Yes	No	No	Yes	5	3
167	2x41	4x42	Shared	7.49	1.875	Yes	No	No	No	5	7
168	2x42	3x45	Shared	6.97	7.875	No	Yes	No	No	8	7
169	2x42	3x46	Shared	12.86	4.215	No	Yes	No	No	8	9
170	2x43	7x53	Shared	15.24	16.41	No	No	Yes	No	8	9
171	2x45	3x42	Shared	8.94	9.685	No	No	No	No	9	8
172	2x45	4x50	Shared	6.18	3.71	No	No	Yes	Yes	9	9
173	2x46	3x42	Shared	5.49	4.81	No	No	No	No	9	8
174	2x46	7x49	Shared	4.12	8.24	No	No	Yes	No	9	9
175	2x49	3x39	Shared	4.8	5.6	Yes	No	No	No	8	9
176	2x50	7x46	Shared	7.36	5.3	No	Yes	No	No	9	9
177	2x53	3x35	Shared	3.38	5.78	No	No	No	No	7	7
178	2x53	7x46	Shared	4.8	2.41	No	No	No	No	7	9
179	2x54	7x46	Shared	3	5.295	No	No	No	No	7	9
180	2x57	2x58	Shared	3.35	2.515	Yes	No	No	No	8	9
181	2x57	7x42	Shared	16.76	7.78	Yes	No	Yes	Yes	8	7
182	2x59	3x28	Shared	7.57	9.46	No	No	Yes	Yes	6	6
183	2x60	7x38	Shared	3.94	7.23	Yes	Yes	No	No	6	6
184	2x60	7x42	Shared	10.1	7.295	Yes	Yes	Yes	Yes	6	7
185	2x62	2x63	Shared	8.14	5.235	Yes	No	Yes	Yes	5	5
186	2x62	2x67	Shared	6.31	5.68	Yes	No	No	No	5	5
187	2x63	E1x50	Shared	14.69	7.91	Yes	Yes	Yes	Yes	5	8
188	2x63	E1x52	Shared	9.67	4.23	Yes	Yes	Yes	No	5	7
189	2x65	2x66	Shared	8.22	2.935	No	No	Yes	No	4	5
190	E1	E1x49	Shared	7.63	11.44	No	No	No	No	4	5
191	E1x50	E2x50	Shared	6.53	10.45	Yes	Yes	No	No	8	9
192	3x22	E2	Shared	8.18	3.985	No	No	Yes	Yes	3	3
193	3x25	E2x50	Shared	7.28	7.28	No	No	No	No	9	9
194	3x28	3x29	Shared	12.91	6.455	Yes	Yes	No	Yes	6	4
195	3x28	3x32	Shared	13.38	5.145	Yes	Yes	No	Yes	6	7
196	3x29	4x65	Shared	10.78	13.17	No	Yes	No	No	4	6
197	3x30	4x62	Shared	10.96	10.96	Yes	Yes	No	No	6	5
198	3x33	4x61	Shared	8.32	9.705	No	No	No	No	5	5
199	3x36	6x48	Shared	4.85	4.245	No	No	Yes	Yes	7	8
200	3x37	4x56	Shared	17.58	14.655	Yes	Yes	No	No	7	6
201	3x37	5x43	Shared	9.3	13.375	Yes	Yes	No	No	7	6
202	3x37	5x46	Shared	3.59	4.79	Yes	Yes	No	No	7	5
203	3x37	5x461	Shared	3.82	7.63	Yes	Yes	Yes	No	7	6
204	3x38	4x50	Shared	3.89	5.835	No	No	Yes	Yes	7	9
205	3x38	4x53	Shared	3.42	3.42	No	No	No	No	7	8
206	3x51	3x55	Shared	6.72	7.39	Yes	No	Yes	No	8	7
207	3x51	5x57	Shared	15.24	7.62	Yes	No	No	No	8	7
208	3x55	3x56	Shared	4.42	2.945	Yes	No	Yes	No	7	6
209	4x39	4x43	Shared	3.71	3.095	No	Yes	No	No	3	3
210	4x40	4x44	Shared	3.06	3.06	No	No	No	No	4	4
211	4x45	4x49	Shared	5.02	3.765	No	No	Yes	No	6	7
212	4x51	4x55	Shared	4.15	0.69	No	No	No	No	3	4
213	4x59	4x60	Shared	3.53	2.58	No	Yes	No	No	5	7
214	4x64	5x39	Shared	3.17	3.97	Yes	No	No	No	5	6
215	4x65	E2x52	Shared	8.39	9.225	No	No	No	No	6	5
216	E2	E2	Shared	36.94	75.05	Yes	Yes	Yes	Yes	3	3
217	E2	E2x51	Shared	11.3	15.94	Yes	Yes	No	No	3	4
218	E2x51	E2x52	Shared	6.99	4.375	No	No	No	No	4	5
219	5x35	E2	Shared	7.6	15.03	No	No	Yes	Yes	4	3
220	5x37	6x59	Shared	6.47	3.235	No	No	Yes	No	4	3
221	5x40	6x55	Shared	7.52	6.89	No	No	Yes	Yes	6	6
222	5x40	6x59	Shared	3.27	5.725	No	No	Yes	No	6	3
223	5x41	6x60	Shared	9.02	4.505	No	No	No	No	5	5
224	5x43	6x55	Shared	6.03	6.63	No	No	Yes	Yes	6	6
225	5x44	6x52	Shared	6.85	9.58	No	No	No	No	6	7
226	5x45	5x48	Shared	6.28	7.475	No	No	No	No	5	5
227	5x47	5x51	Shared	8.71	3.73	Yes	Yes	No	No	8	6
228	5x47	6x49	Shared	7.31	4.875	Yes	Yes	No	No	8	7
229	5x47	6x52	Shared	15.84	3.96	Yes	Yes	No	No	8	7
230	5x49	5x50	Shared	4.33	4.33	No	No	No	No	6	9
231	5x51	6x45	Shared	3.04	1.52	No	No	No	No	6	7
232	5x58	6x37	Shared	3.79	8.24	Yes	Yes	No	Yes	9	8
233	5x72	6x26	Shared	7.65	2.765	No	No	No	No	5	4
234	6x27	6x31	Shared	11.91	3.925	No	No	No	No	3	5
235	6x36	7x56	Shared	7.45	7.215	No	No	No	No	8	7
236	6x43	7x48	Shared	3.25	0.81	No	No	No	No	7	6
237	6x44	6x48	Shared	12.03	9.525	No	Yes	Yes	Yes	9	8
238	6x47	7x45	Shared	3.44	5.16	No	No	No	No	9	9
239	6x48	7x41	Shared	4.01	6.46	Yes	Yes	Yes	No	8	7
240	6x48	7x45	Shared	9.88	6.795	Yes	Yes	No	No	8	9
241	6x49	6x50	Shared	3.28	3.28	No	No	No	No	7	9
242	6x50	7x40	Shared	3.28	4.93	No	No	No	No	9	7
243	6x51	6x54	Shared	3.09	7.715	No	Yes	Yes	Yes	6	5
244	6x51	6x55	Shared	10.29	9.775	No	Yes	Yes	Yes	6	6
245	6x54	6x55	Shared	4.26	4.265	Yes	Yes	Yes	Yes	5	6
246	6x54	7x34	Shared	12.35	11.835	Yes	Yes	No	Yes	5	4
247	6x54	7x37	Shared	11.64	8.41	Yes	Yes	No	No	5	6
248	6x58	Lig	Shared	30.17	21.17	No	No	Yes	Yes	4	0
249	7x30	E3	Shared	13.5	4.825	Yes	Yes	No	Yes	4	3
250	E3	Lig	Shared	6.68	35.6	No	Yes	Yes	Yes	3	0
251	7x23	7x24	Shared	5.25	3.32	No	No	No	No	4	4
252	7x23	7x26	Shared	4.42	4.42	No	No	No	No	4	1
253	7x27	Lig	Shared	3.06	15.4	No	No	Yes	Yes	2	0
254	7x30	Lig	Shared	8.41	13.925	Yes	Yes	Yes	Yes	4	0
255	7x33	7x37	Shared	5.19	7.135	No	Yes	No	No	4	6
256	7x34	7x38	Shared	5.81	12.795	No	Yes	No	No	4	6
257	7x34	Lig	Shared	12.99	6.645	No	Yes	Yes	Yes	4	0
258	7x41	7x42	Shared	10.32	5.505	Yes	No	Yes	Yes	7	7
259	7x48	7x52	Shared	5.71	1.425	No	No	No	No	6	8
260	7x54	8x50	Shared	8.46	4.835	No	No	Yes	Yes	7	8
261	7x54	8x51	Shared	3.62	3.015	No	No	No	No	7	9
262	7x54	8x54	Shared	15.71	17.52	No	No	Yes	Yes	7	7
263	8x47	8x49	Shared	7.45	1.49	No	No	No	No	8	7
264	8x50	8x54	Shared	11.79	4.82	Yes	Yes	Yes	Yes	8	7
265	8x54	8x58	Shared	4.87	1.825	Yes	Yes	No	No	7	7
266	1x51	2x51	Shared	2.95	2.225	No	No	No	No	4	7
267	1x53	1x57	Shared	2.95	3.685	No	No	No	No	9	7
268	5x32	5x34	Shared	2.93	1.465	No	No	No	No	4	1
269	2x39	3x49	Shared	2.85	6.42	No	No	Yes	No	8	8
270	3x41	4x49	Shared	2.85	2.14	No	No	Yes	No	6	7
271	2x551	3x31	Shared	2.77	4.15	No	No	No	No	5	5
272	3x30	4x57	Shared	2.77	4.16	Yes	Yes	No	No	6	7
273	3x52	I2x56	Shared	2.77	2.77	Yes	No	No	No	4	4
274	4x38	4x41	Shared	2.64	7.25	No	No	No	No	8	5
275	8x47	8x50	Shared	2.64	3.96	No	No	Yes	Yes	8	8
276	4x59	4x63	Shared	2.62	3.85	No	Yes	No	No	5	4
277	3x47	5x58	Shared	2.54	5.215	No	No	Yes	Yes	9	9
278	1x43	2x57	Shared	2.49	6.22	No	No	Yes	No	7	8
279	3x40	5x50	Shared	1.87	2.805	No	No	No	No	8	9
280	1x48	1x49	Shared	1.84	2.76	No	No	No	No	5	9
281	3x34	4x57	Shared	1.79	1.79	No	No	No	No	6	7
282	1x54	2x44	Shared	1.71	1.71	No	No	No	No	8	6
283	1x57	2x44	Shared	1.71	1.71	No	No	No	No	7	6
284	6x47	7x43	Shared	1.71	2.565	No	No	No	No	9	5
285	3x44	5x53	Shared	1.7	3.255	No	No	No	No	8	6
286	3x43	6x40	Shared	1.6	1.6	No	No	No	No	8	8
287	5x38	5x42	Shared	1.6	1.6	No	No	No	No	4	5
288	3x56	I2x50	Shared	1.53	1.53	Yes	No	No	No	6	8
289	3x24	E1x52	Shared	1.51	3.765	No	No	Yes	No	6	7
290	3x27	3x30	Shared	1.51	1.51	No	No	Yes	Yes	5	6
291	3x48	5x57	Shared	1.49	2.98	No	No	No	No	7	7
292	5x59	5x63	Shared	1.47	1.46	No	No	No	No	3	4
293	3x30	4x54	Shared	1.39	0.695	Yes	Yes	No	No	6	4
294	1x54	2x48	Shared	1.38	2.77	No	No	No	No	8	6
295	1x39	7x39	Shared	1.33	4.67	Yes	Yes	No	No	7	5
296	1x55	8x57	Shared	1.3	1.295	No	No	Yes	No	4	5
297	Lig	NT	neurotensin_on	0	11.39	Yes	Yes	No	Yes	0	0
298	Lig	Lig	neurotensin_on	0	11.2	Yes	Yes	Yes	Yes	0	0
299	7x31	Lig	neurotensin_on	0	5.905	No	Yes	Yes	Yes	4	0
300	E1	Lig	neurotensin_on	0	6.345	No	No	Yes	Yes	4	0
301	E2	Lig	neurotensin_on	0	13.88	Yes	Yes	Yes	Yes	3	0
302	2x64	Lig	neurotensin_on	0	4.395	No	Yes	Yes	Yes	4	0
303	3x29	Lig	neurotensin_on	0	5.86	No	Yes	Yes	Yes	4	0
304	4x65	Lig	neurotensin_on	0	4.945	No	No	Yes	Yes	6	0
305	6x55	Lig	neurotensin_on	0	7.895	Yes	Yes	Yes	Yes	6	0
306	E2	NT	neurotensin_on	0	19.075	Yes	Yes	No	Yes	3	0
307	E1	NT	neurotensin_on	0	25.285	No	No	No	Yes	4	0
308	NT	NT	neurotensin_on	0	4.405	No	Yes	No	Yes	0	0
309	7x27	NT	neurotensin_on	0	3.81	No	No	No	Yes	2	0
310	7x31	NT	neurotensin_on	0	19.375	No	Yes	No	Yes	4	0
311	1x32	NT	neurotensin_on	0	5.255	No	No	No	Yes	5	0
312	7x32	NT	neurotensin_on	0	14.635	No	No	No	Yes	1	0
313	1x31	7x32	neurotensin_on	0	3.82	No	No	No	No	3	1
314	1x32	2x65	neurotensin_on	0	5.815	No	No	No	No	5	4
315	1x35	7x35	neurotensin_on	0	4.565	No	No	No	No	5	3
316	1x42	7x47	neurotensin_on	0	3.74	No	No	No	No	7	7
317	1x53	8x54	neurotensin_on	0	3.245	No	No	Yes	Yes	9	7
318	2x35	I2x54	neurotensin_on	0	3.525	No	No	No	No	0	4
319	2x38	4x42	neurotensin_on	0	9.42	No	Yes	No	No	7	7
320	2x42	3x49	neurotensin_on	0	7.625	No	Yes	Yes	No	8	8
321	2x42	4x45	neurotensin_on	0	5.875	No	Yes	No	No	8	6
322	2x42	4x46	neurotensin_on	0	7.175	No	Yes	No	No	8	7
323	2x43	3x46	neurotensin_on	0	3.46	No	No	No	No	8	9
324	2x48	2x52	neurotensin_on	0	3.46	No	No	No	No	6	8
325	2x48	4x50	neurotensin_on	0	4.555	No	No	Yes	Yes	6	9
326	2x50	3x39	neurotensin_on	0	6.505	No	Yes	No	No	9	9
327	2x50	7x49	neurotensin_on	0	7.405	No	Yes	Yes	No	9	9
328	2x51	2x55	neurotensin_on	0	5.535	No	No	No	No	7	5
329	2x54	7x42	neurotensin_on	0	4.1	No	No	Yes	Yes	7	7
330	2x56	7x42	neurotensin_on	0	3.335	No	No	Yes	Yes	7	7
331	2x60	2x64	neurotensin_on	0	6.415	Yes	Yes	No	Yes	6	4
332	2x60	3x28	neurotensin_on	0	3.93	Yes	Yes	Yes	Yes	6	6
333	2x60	7x34	neurotensin_on	0	4.49	Yes	Yes	No	Yes	6	4
334	2x64	3x29	neurotensin_on	0	3.61	No	Yes	No	Yes	4	4
335	2x64	7x34	neurotensin_on	0	7.74	No	Yes	No	Yes	4	4
336	3x21	E1x50	neurotensin_on	0	3.515	No	No	Yes	Yes	8	8
337	3x25	E2	neurotensin_on	0	3.545	No	No	Yes	Yes	9	3
338	3x30	4x59	neurotensin_on	0	3.165	Yes	Yes	No	Yes	6	5
339	3x32	6x51	neurotensin_on	0	6.175	No	Yes	No	Yes	7	6
340	3x33	5x43	neurotensin_on	0	6.73	No	No	No	No	5	6
341	3x39	6x48	neurotensin_on	0	4.85	No	No	Yes	Yes	9	8
342	3x42	4x50	neurotensin_on	0	3.39	No	No	Yes	Yes	8	9
343	3x46	3x50	neurotensin_on	0	9.11	No	No	Yes	No	9	9
344	3x47	5x57	neurotensin_on	0	3.75	No	No	No	No	9	7
345	3x50	7x53	neurotensin_on	0	4.115	Yes	No	Yes	No	9	9
346	4x56	5x46	neurotensin_on	0	4.24	No	No	No	No	6	5
347	5x36	E2x52	neurotensin_on	0	5.115	No	No	No	No	5	5
348	5x37	5x41	neurotensin_on	0	3.39	No	No	No	No	4	5
349	5x37	6x60	neurotensin_on	0	5.375	No	No	No	No	4	5
350	5x49	5x53	neurotensin_on	0	3.275	No	No	No	No	6	6
351	5x50	6x44	neurotensin_on	0	4.335	No	No	No	Yes	9	9
352	5x54	6x44	neurotensin_on	0	3.77	No	No	No	Yes	8	9
353	5x64	5x68	neurotensin_on	0	3.6	No	No	No	No	5	6
354	5x65	6x30	neurotensin_on	0	3.46	No	No	No	No	8	7
355	5x69	6x30	neurotensin_on	0	4.47	No	No	No	No	6	7
356	5x69	6x31	neurotensin_on	0	5.23	No	No	No	No	6	5
357	I3	I3	neurotensin_on	0	14.73	No	No	No	No	0	0
358	6x24	I3	neurotensin_on	0	6.745	No	No	No	No	0	0
359	6x32	7x56	neurotensin_on	0	3.345	No	No	No	No	8	7
360	6x51	6x52	neurotensin_on	0	8.165	No	Yes	No	No	6	7
361	6x54	7x30	neurotensin_on	0	9.26	Yes	Yes	Yes	Yes	5	4
362	6x54	7x33	neurotensin_on	0	5.34	Yes	Yes	No	Yes	5	4
363	6x56	6x60	neurotensin_on	0	7.035	No	No	No	No	6	5
364	6x58	7x30	neurotensin_on	0	7.22	No	No	Yes	Yes	4	4
365	6x61	E3	neurotensin_on	0	18.22	No	No	No	Yes	3	3
366	E3	E3	neurotensin_on	0	11.02	No	Yes	No	Yes	3	3
367	7x26	E3	neurotensin_on	0	3.42	No	No	No	Yes	1	3
368	7x27	7x31	neurotensin_on	0	15.54	No	No	No	Yes	2	4
369	7x30	7x31	neurotensin_on	0	4.355	Yes	Yes	No	Yes	4	4
370	1x30	NT	neurotensin_on	0	3.45	No	No	No	Yes	2	0
371	1x31	NT	neurotensin_on	0	3.68	No	No	No	Yes	3	0
372	1x55	1x59	neurotensin_on	0	6.415	No	No	No	No	4	5
373	2x36	2x38	neurotensin_on	0	3.545	No	No	No	Yes	0	7
374	2x38	I2x57	neurotensin_on	0	7.525	No	Yes	No	No	7	7
375	E1x50	E2	neurotensin_on	0	15.375	Yes	Yes	Yes	Yes	8	3
376	3x29	3x32	neurotensin_on	0	4.115	No	Yes	No	Yes	4	7
377	3x32	3x33	neurotensin_on	0	6.55	No	Yes	No	No	7	5
378	3x32	6x55	neurotensin_on	0	5.865	No	Yes	Yes	Yes	7	6
379	3x43	6x44	neurotensin_on	0	3.935	No	No	No	Yes	8	9
380	3x56	I2x52	neurotensin_on	0	3.93	Yes	No	No	No	6	4
381	7x48	7x51	neurotensin_on	0	4.415	No	No	No	No	6	6
382	5x62	6x37	neurotensin_on	0	3.15	No	No	No	Yes	6	8
383	3x51	5x60	neurotensin_on	0	3.075	Yes	No	No	No	8	5
384	6x37	6x38	neurotensin_on	0	3.035	No	Yes	No	Yes	8	5
385	3x26	E2	neurotensin_on	0	3	No	No	Yes	Yes	7	3
386	6x28	6x32	neurotensin_on	0	2.985	No	No	No	No	5	8
387	6x36	7x52	neurotensin_on	0	2.98	No	No	No	No	8	8
388	3x54	5x64	neurotensin_on	0	2.91	No	No	No	No	9	5
389	I2x50	I2x51	neurotensin_on	0	2.89	No	No	No	No	8	7
390	8x52	8x56	neurotensin_on	0	2.89	No	No	No	No	4	4
391	6x24	6x26	neurotensin_on	0	2.88	No	No	No	No	0	4
392	5x61	6x37	neurotensin_on	0	2.85	No	No	No	Yes	9	8
393	5x54	5x58	neurotensin_on	0	2.83	No	No	Yes	Yes	8	9
394	5x65	5x68	neurotensin_on	0	2.825	No	No	No	No	8	6
395	8x48	8x51	neurotensin_on	0	2.765	No	No	No	No	4	9
396	4x60	5x39	neurotensin_on	0	2.65	No	No	No	No	7	6
397	1x60	2x40	neurotensin_on	0	2.62	No	No	No	No	0	8
398	6x34	6x38	neurotensin_on	0	2.615	No	No	No	Yes	7	5
399	5x59	6x38	neurotensin_on	0	2.585	No	No	No	Yes	3	5
400	5x47	5x48	neurotensin_on	0	2.495	Yes	Yes	No	No	8	5
401	2x36	2x40	neurotensin_on	0	2.475	No	No	No	No	0	8
402	3x26	4x62	neurotensin_on	0	2.425	No	No	No	No	7	5
403	3x52	I2x53	neurotensin_on	0	2.365	Yes	No	No	No	4	6
404	2x63	E1x51	neurotensin_on	0	2.345	Yes	Yes	No	No	5	3
405	4x39	I1	neurotensin_on	0	2.335	No	Yes	No	No	3	0
406	5x55	5x56	neurotensin_on	0	2.32	No	No	No	No	5	5
407	1x28	7x32	neurotensin_on	0	2.3	No	No	No	No	0	1
408	5x65	6x34	neurotensin_on	0	2.235	No	No	No	No	8	7
409	7x55	7x56	neurotensin_on	0	2.235	No	No	No	No	6	7
410	1x34	1x35	neurotensin_on	0	2.235	No	No	No	No	5	5
411	5x58	6x41	neurotensin_on	0	2.215	Yes	Yes	No	No	9	8
412	7x28	NT	neurotensin_on	0	2.19	No	No	No	Yes	1	0
413	1x29	1x32	neurotensin_on	0	2.18	No	No	No	No	2	5
414	1x34	1x38	neurotensin_on	0	2.17	No	No	No	No	5	4
415	6x27	6x28	neurotensin_on	0	2.15	No	No	No	No	3	5
416	8x52	8x53	neurotensin_on	0	2.15	No	No	No	No	4	6
417	6x56	6x57	neurotensin_on	0	2.12	No	No	Yes	No	6	4
418	3x52	I2x52	neurotensin_on	0	2.115	Yes	No	No	No	4	4
419	2x52	2x551	neurotensin_on	0	2.075	No	No	No	No	8	5
420	6x53	7x33	neurotensin_on	0	1.965	No	No	No	Yes	5	4
421	I2x51	I2x55	neurotensin_on	0	1.945	No	No	No	No	7	4
422	7x23	7x25	neurotensin_on	0	1.945	No	No	No	No	4	2
423	6x33	6x36	neurotensin_on	0	1.84	No	No	No	No	8	8
424	5x72	6x27	neurotensin_on	0	1.7	No	No	No	No	5	3
425	1x44	1x45	neurotensin_on	0	1.6	No	No	No	No	5	6
426	5x66	6x34	neurotensin_on	0	1.585	No	No	No	No	5	7
427	6x39	7x52	neurotensin_on	0	1.58	No	No	No	No	7	8
428	3x22	3x23	neurotensin_on	0	1.54	No	No	No	No	3	1
429	5x51	5x55	neurotensin_on	0	1.535	No	No	No	No	6	5
430	1x29	1x33	neurotensin_on	0	1.535	No	No	No	No	2	6
431	5x52	5x56	neurotensin_on	0	1.515	No	No	No	No	3	5
432	2x34	I1	neurotensin_on	0	1.5	No	No	No	No	0	0
433	1x40	2x61	neurotensin_on	0	1.38	No	No	No	No	5	6
434	8x55	8x58	neurotensin_on	0	1.38	No	No	No	No	4	7
435	5x71	5x74	neurotensin_on	0	1.275	No	No	No	No	7	5
436	7x29	7x33	neurotensin_on	0	1.07	No	No	No	Yes	4	4
437	6x24	6x25	neurotensin_on	0	1.015	No	No	No	No	0	0
438	1x45	1x46	neurotensin_on	0	0.92	No	No	No	No	6	8
439	6x46	6x47	neurotensin_on	0	0.855	No	No	No	No	6	9
440	4x38	4x40	neurotensin_on	0	0.815	No	No	No	No	8	4
441	1x41	1x42	neurotensin_on	0	0.79	No	No	No	No	4	7
442	4x46	4x47	neurotensin_on	0	0.775	No	No	No	No	7	4
443	6x42	6x46	neurotensin_on	0	0.77	No	No	No	No	5	6
444	5x34	E2	neurotensin_on	0	0.77	No	No	Yes	Yes	1	3
445	6x41	6x42	neurotensin_on	0	0.77	No	No	No	No	8	5
446	2x34	2x35	neurotensin_on	0	0.75	No	No	No	No	0	0
447	4x55	4x59	neurotensin_on	0	0.745	No	No	No	Yes	4	5
448	5x63	5x67	neurotensin_on	0	0.74	No	No	No	No	4	4
449	5x41	5x42	neurotensin_on	0	0.715	No	No	No	No	5	5
450	8x58	8x61	neurotensin_on	0	0.69	No	No	No	No	7	0
451	5x66	5x70	neurotensin_on	0	0.685	No	No	No	No	5	4
452	4x38	4x39	neurotensin_on	0	0.66	No	No	No	Yes	8	3
453	5x71	5x75	neurotensin_on	0	0.64	No	No	No	No	7	4
454	5x70	5x71	neurotensin_on	0	0.62	No	No	No	No	4	7
455	7x33	7x36	neurotensin_on	0	0.61	No	Yes	No	No	4	6
456	6x35	6x38	neurotensin_on	0	0.535	No	No	No	Yes	7	5

Orange: nodes, hubs and links specific of neurotensin_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of neurotensin_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	neurotensin_off Avg Int. Strength	neurotensin_on Avg Int. Strength	neurotensin_off Num Of Links	neurotensin_on Num Of Links	ConSurf
1	1x52	neurotensin_off	5.7225	3.0875	4	2	6
2	1x56	neurotensin_off	4.318	4.445	5	3	7
3	2x41	neurotensin_off	6.12	4.41833	4	3	5
4	2x49	neurotensin_off	4.262	5.6	5	1	8
5	2x57	neurotensin_off	7.745	5.505	4	3	8
6	2x62	neurotensin_off	5.8275	5.4575	4	2	5
7	2x66	neurotensin_off	8.5725	4.8025	4	2	5
8	E1x52	neurotensin_off	6.666	3.9975	5	2	7
9	3x49	neurotensin_off	7.9675	6.56333	4	3	8
10	3x50	neurotensin_off	6.922	6.6125	5	2	9
11	3x51	neurotensin_off	6.686	6.02833	5	3	8
12	3x52	neurotensin_off	3.9175	2.41667	4	3	4
13	3x55	neurotensin_off	4.3	5.1675	4	2	7
14	3x56	neurotensin_off	3.8625	2.80167	4	3	6
15	4x49	neurotensin_off	3.45	2.9525	4	2	7
16	4x64	neurotensin_off	4.565	3.97	4	1	5
17	5x461	neurotensin_off	4.6625	7.63	4	1	6
18	6x57	neurotensin_off	5.41	2.12	4	1	4
19	6x59	neurotensin_off	5.35	4.48	4	2	3
20	7x41	neurotensin_off	8.83	5.9825	4	2	7
21	7x49	neurotensin_off	4.212	7.8225	5	2	9
22	7x50	neurotensin_off	4.335	4.13	4	3	9
23	7x53	neurotensin_off	9.3	10.2625	4	2	9
24	8x57	neurotensin_off	3.9125	1.44	4	2	5
25	1x39	Shared	5.19714	3.845	7	4	7
26	1x50	Shared	6.8625	4.7625	4	4	9
27	2x60	Shared	5.904	5.45417	5	6	6
28	2x63	Shared	8.865	4.93	4	4	5
29	E1x50	Shared	9.2925	9.3125	4	4	8
30	3x28	Shared	10.27	6.2475	4	4	6
31	3x30	Shared	4.1575	4.098	4	5	6
32	3x37	Shared	8.5725	10.1125	4	4	7
33	4x50	Shared	4.015	4.3725	4	4	9
34	E2	Shared	13.0744	21.8818	9	11	3
35	5x47	Shared	9.0375	3.765	4	4	8
36	5x58	Shared	6.6075	4.625	4	4	9
37	6x48	Shared	7.6925	6.375	4	5	8
38	6x54	Shared	8.34	7.80417	6	6	5
39	6x55	Shared	7.025	6.88667	4	6	6
40	7x30	Shared	8.1975	7.917	4	5	4
41	7x42	Shared	11.53	5.603	4	5	7
42	8x50	Shared	7.42	4.8625	5	4	8
43	8x54	Shared	9.61	6.1975	5	6	7
44	Lig	Shared	10.865	11.717	8	15	0
45	NT	neurotensin_on	0	9.74625	0	12	0
46	2x38	neurotensin_on	4.23	6.53375	1	4	7
47	2x42	neurotensin_on	9.915	6.553	2	5	8
48	2x50	neurotensin_on	10.07	5.8125	3	4	9
49	2x64	neurotensin_on	7.22	5.54	1	4	4
50	3x29	neurotensin_on	9.09333	6.642	3	5	4
51	3x32	neurotensin_on	11.71	5.57	3	5	7
52	4x39	neurotensin_on	5.39333	4.195	3	5	3
53	4x59	neurotensin_on	3.04333	2.585	3	4	5
54	6x37	neurotensin_on	4	4.31875	3	4	8
55	6x38	neurotensin_on	7.285	2.1925	2	4	5
56	6x44	neurotensin_on	6.36333	5.39125	3	4	9
57	6x51	neurotensin_on	6.69	7.9575	2	4	6
58	E3	neurotensin_on	8.65667	14.0175	3	6	3
59	7x31	neurotensin_on	4.92	11.2937	2	4	4
60	7x33	neurotensin_on	6.325	3.224	2	5	4
61	7x34	neurotensin_on	10.3833	8.701	3	5	4

Orange: nodes, hubs and links specific of neurotensin_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of neurotensin_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	neurotensin_off Recurrence	neurotensin_on Recurrence	neurotensin_off Hub1?	neurotensin_on Hub1?	neurotensin_off Hub2?	neurotensin_on Hub2?	ConSurf1	ConSurf2
1	2x65	2x66	neurotensin_off	11.673	2.39565	No	No	Yes	No	4	5
2	2x60	2x65	neurotensin_off	12.8706	0	Yes	Yes	No	No	6	4
3	2x60	3x32	neurotensin_off	36.8492	0	Yes	Yes	No	Yes	6	7
4	3x32	7x41	neurotensin_off	55.4097	0	No	Yes	Yes	No	7	7
5	2x53	7x41	neurotensin_off	100	0	No	No	Yes	No	7	7
6	2x53	7x46	neurotensin_off	49.4216	2.05667	No	No	No	No	7	9
7	7x49	7x50	neurotensin_off	37.3422	0	Yes	No	Yes	No	9	9
8	7x49	7x53	neurotensin_off	15.2851	0	Yes	No	Yes	No	9	9
9	7x53	8x50	neurotensin_off	11.8197	0	Yes	No	Yes	Yes	9	8
10	2x53	3x35	neurotensin_off	52.9904	1.0296	No	No	No	No	7	7
11	2x49	3x35	neurotensin_off	51.6726	0	Yes	No	No	No	8	7
12	2x49	4x50	neurotensin_off	49.8617	0	Yes	No	Yes	Yes	8	9
13	2x45	4x50	neurotensin_off	49.5924	0.151783	No	No	Yes	Yes	9	9
14	2x45	3x42	neurotensin_off	46.9831	0.872755	No	No	No	No	9	8
15	3x42	4x49	neurotensin_off	48.4741	0	No	No	Yes	No	8	7
16	3x45	4x49	neurotensin_off	46.4348	0	No	No	Yes	No	7	7
17	2x42	3x45	neurotensin_off	45.9803	1.0296	No	Yes	No	No	8	7
18	2x42	3x46	neurotensin_off	45.3551	5.07716	No	Yes	No	No	8	9
19	3x46	6x37	neurotensin_off	44.7082	0	No	No	No	Yes	9	8
20	3x50	6x37	neurotensin_off	31.0968	0	Yes	No	No	Yes	9	8
21	2x60	7x38	neurotensin_off	61.3809	0.447761	Yes	Yes	No	No	6	6
22	3x28	3x29	neurotensin_off	22.3769	2.06931	Yes	Yes	No	Yes	6	4
23	3x36	6x48	neurotensin_off	10.6823	1.0296	No	No	Yes	Yes	7	8
24	3x36	5x461	neurotensin_off	10.1724	0	No	No	Yes	No	7	6
25	6x54	7x38	neurotensin_off	35.6444	0	Yes	Yes	No	No	5	6
26	6x40	7x49	neurotensin_off	27.1217	0	No	No	Yes	No	8	9
27	3x43	6x40	neurotensin_off	26.4916	1.0296	No	No	No	No	8	8
28	3x43	6x41	neurotensin_off	25.8615	0	No	No	No	No	8	8
29	5x54	6x41	neurotensin_off	25.2315	0	No	No	No	No	8	8
30	3x47	5x54	neurotensin_off	23.3485	0	No	No	No	No	9	8
31	5x58	5x61	neurotensin_off	32.1862	0	Yes	Yes	No	No	9	9
32	3x51	5x61	neurotensin_off	21.2491	0	Yes	No	No	No	8	9
33	3x54	3x55	neurotensin_off	12.7047	0	No	No	Yes	No	9	7
34	6x54	Lig	neurotensin_off	25.3277	0	Yes	Yes	Yes	Yes	5	0
35	5x40	Lig	neurotensin_off	13.758	0	No	No	Yes	Yes	6	0
36	7x34	7x38	neurotensin_off	24.8299	0.288389	No	Yes	No	No	4	6
37	3x55	5x64	neurotensin_off	17.4711	0	Yes	No	No	No	7	5
38	3x50	3x53	neurotensin_off	18.3681	0	Yes	No	No	No	9	8
39	3x53	6x30	neurotensin_off	17.3821	0	No	No	No	No	8	7
40	5x72	6x30	neurotensin_off	16.5043	0	No	No	No	No	5	7
41	7x27	Lig	neurotensin_off	11.5023	1.00683	No	No	Yes	Yes	2	0
42	7x30	Lig	neurotensin_off	13.8206	1.74804	Yes	Yes	Yes	Yes	4	0
43	3x29	4x61	neurotensin_off	13.9312	0	No	Yes	No	No	4	5
44	2x60	7x42	Shared	31.876	100	Yes	Yes	Yes	Yes	6	7
45	6x48	7x41	Shared	24.2527	49.4662	Yes	Yes	Yes	No	8	7
46	7x41	7x42	Shared	37.2051	49.7243	Yes	No	Yes	Yes	7	7
47	2x50	7x46	Shared	47.7383	48.0648	No	Yes	No	No	9	9
48	1x50	2x50	Shared	47.2284	51.9782	Yes	Yes	No	Yes	9	9
49	1x50	7x50	Shared	39.0857	48.3734	Yes	Yes	Yes	No	9	9
50	3x28	3x32	Shared	31.1618	16.4078	Yes	Yes	No	Yes	6	7
51	5x58	6x37	Shared	20.7657	34.8672	Yes	Yes	No	Yes	9	8
52	3x47	5x58	Shared	22.7569	13.9868	No	No	Yes	Yes	9	9
53	5x40	6x55	Shared	10.4538	18.0521	No	No	Yes	Yes	6	6
54	5x40	6x59	Shared	18.0819	16.0663	No	No	Yes	No	6	3
55	7x34	Lig	Shared	23.8102	33.2431	No	Yes	Yes	Yes	4	0
56	6x44	6x48	Shared	11.4085	52.9522	No	Yes	Yes	Yes	9	8
57	Lig	NT	neurotensin_on	0	12.5323	Yes	Yes	No	Yes	0	0
58	2x60	2x64	neurotensin_on	0	34.2398	Yes	Yes	No	Yes	6	4
59	2x64	Lig	neurotensin_on	0	32.2742	No	Yes	Yes	Yes	4	0
60	2x60	7x34	neurotensin_on	0	48.2823	Yes	Yes	No	Yes	6	4
61	2x54	7x46	neurotensin_on	6.81048	48.8237	No	No	No	No	7	9
62	2x54	7x42	neurotensin_on	0	49.451	No	No	Yes	Yes	7	7
63	1x53	8x54	neurotensin_on	0	17.536	No	No	Yes	Yes	9	7
64	1x53	7x50	neurotensin_on	3.24411	46.2029	No	No	Yes	No	9	9
65	1x53	1x57	neurotensin_on	2.27497	31.8644	No	No	No	No	9	7
66	2x41	4x42	neurotensin_on	3.82368	11.5482	Yes	No	No	No	5	7
67	2x38	4x42	neurotensin_on	0	12.5196	No	Yes	No	No	7	7
68	2x36	2x38	neurotensin_on	0	27.1718	No	No	No	Yes	0	7
69	2x36	2x40	neurotensin_on	0	28.0572	No	No	No	No	0	8
70	1x57	2x40	neurotensin_on	0.988385	29.6003	No	No	No	No	7	8
71	2x38	3x49	neurotensin_on	0.954717	13.7288	No	Yes	Yes	No	7	8
72	2x42	3x49	neurotensin_on	0	11.8998	No	Yes	Yes	No	8	8
73	2x50	7x49	neurotensin_on	0	10.6729	No	Yes	Yes	No	9	9
74	3x39	6x48	neurotensin_on	0	16.6861	No	No	Yes	Yes	9	8
75	E1x50	E2	neurotensin_on	0	10.344	Yes	Yes	Yes	Yes	8	3
76	E2	Lig	neurotensin_on	0	33.195	Yes	Yes	Yes	Yes	3	0
77	3x30	4x62	neurotensin_on	3.25854	13.9312	Yes	Yes	No	No	6	5
78	3x26	4x62	neurotensin_on	0	15.0594	No	No	No	No	7	5
79	3x26	E2	neurotensin_on	0	16.0359	No	No	Yes	Yes	7	3
80	6x55	Lig	neurotensin_on	0	19.0235	Yes	Yes	Yes	Yes	6	0
81	5x43	6x55	neurotensin_on	6.84414	10.4123	No	No	Yes	Yes	6	6
82	5x54	5x58	neurotensin_on	0	46.3547	No	No	Yes	Yes	8	9
83	5x54	6x44	neurotensin_on	0	47.1035	No	No	No	Yes	8	9
84	3x47	5x57	neurotensin_on	0	13.0205	No	No	No	No	9	7
85	3x51	5x57	neurotensin_on	3.2393	11.0726	Yes	No	No	No	8	7
86	5x37	6x59	neurotensin_on	7.24575	14.0754	No	No	Yes	No	4	3
87	6x51	6x52	neurotensin_on	0	14.7964	No	Yes	No	No	6	7
88	5x47	6x52	neurotensin_on	4.66537	12.5753	Yes	Yes	No	No	8	7
89	5x65	6x34	neurotensin_on	0	22.894	No	No	No	No	8	7
90	6x34	6x38	neurotensin_on	0	27.956	No	No	No	Yes	7	5
91	6x37	6x38	neurotensin_on	0	32.3071	No	Yes	No	Yes	8	5
92	5x69	6x30	neurotensin_on	0	18.6162	No	No	No	No	6	7
93	5x65	6x30	neurotensin_on	0	19.4308	No	No	No	No	8	7
94	5x69	6x31	neurotensin_on	0	17.6727	No	No	No	No	6	5
95	6x27	6x31	neurotensin_on	2.11384	16.7291	No	No	No	No	3	5
96	6x27	6x28	neurotensin_on	0	10.9461	No	No	No	No	3	5
97	6x54	7x34	neurotensin_on	0.0480966	16.8404	Yes	Yes	No	Yes	5	4
98	2x60	3x28	neurotensin_on	0	18.7832	Yes	Yes	Yes	Yes	6	6
99	2x50	3x39	neurotensin_on	0	15.4263	No	Yes	No	No	9	9

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
1x32	E1	neurotensin_off	5.24	0	0	1	2	1
2x60	3x32	neurotensin_off	4.65	0	1	1	2	2
2x60	7x38	Shared	3.94	7.23	1	1	2	2
2x64	3x28	neurotensin_off	7.22	0	0	1	1	2
E1	E1x49	Shared	7.63	11.44	4	1	1	2
E1	E2	neurotensin_off	7.33	0	4	1	1	1
3x25	E1x50	neurotensin_off	3.92	0	3	1	2	2
3x21	E2	neurotensin_off	3.27	0	0	0	2	1
3x22	3x26	neurotensin_off	10.72	0	4	1	2	2
3x22	E2	Shared	8.18	3.985	4	1	2	1
3x28	3x29	Shared	12.91	6.455	0	1	2	1
3x28	3x32	Shared	13.38	5.145	0	1	2	2
3x29	4x61	neurotensin_off	3.59	0	0	1	1	2
3x29	4x65	Shared	10.78	13.17	0	1	1	1
4x61	4x64	neurotensin_off	7.53	0	0	0	2	2
4x64	4x65	neurotensin_off	4.52	0	4	0	2	1
4x64	E2	neurotensin_off	3.04	0	4	0	2	1
4x65	E2x52	Shared	8.39	9.225	0	1	1	2
E2	E2	Shared	36.94	75.05	4	1	1	1
E2	E2x51	Shared	11.3	15.94	4	1	1	2
E2x51	E2x52	Shared	6.99	4.375	4	1	2	2
5x35	E2	Shared	7.6	15.03	4	0	2	1
5x36	E2	neurotensin_off	3.07	0	0	0	2	1
5x40	6x55	Shared	7.52	6.89	0	0	1	1
5x40	6x59	Shared	3.27	5.725	0	0	1	2
5x40	Lig	neurotensin_off	4.65	0	0	0	1	0
5x43	6x55	Shared	6.03	6.63	1	0	2	1
6x51	6x54	Shared	3.09	7.715	1	1	2	1
6x51	6x55	Shared	10.29	9.775	1	1	2	1
6x54	6x55	Shared	4.26	4.265	1	1	1	1
6x54	7x34	Shared	12.35	11.835	1	1	1	1
6x54	7x37	Shared	11.64	8.41	1	1	1	2
6x54	7x38	neurotensin_off	6.03	0	1	1	1	2
6x54	Lig	neurotensin_off	12.67	0	1	1	1	0
6x57	6x61	neurotensin_off	4.37	0	0	0	1	2
6x57	7x33	neurotensin_off	7.46	0	0	0	1	2
6x57	Lig	neurotensin_off	8.29	0	0	0	1	0
6x58	Lig	Shared	30.17	21.17	0	1	1	0
7x27	E3	neurotensin_off	5.79	0	1	1	1	1
7x30	E3	Shared	13.5	4.825	1	1	1	1
E3	Lig	Shared	6.68	35.6	1	1	1	0
7x26	7x30	neurotensin_off	4.69	0	0	1	2	1
7x27	Lig	Shared	3.06	15.4	1	1	1	0
7x28	7x32	neurotensin_off	3.45	0	0	0	2	2
7x29	7x30	neurotensin_off	6.19	0	0	0	2	1
7x30	Lig	Shared	8.41	13.925	1	1	1	0
7x31	7x32	neurotensin_off	3.27	0	0	1	1	2
7x31	7x35	neurotensin_off	6.57	0	0	1	1	2
7x33	7x37	Shared	5.19	7.135	0	1	2	2
7x34	7x38	Shared	5.81	12.795	1	1	1	2
7x34	Lig	Shared	12.99	6.645	1	1	1	0
7x27	7x28	neurotensin_off	2.3	0	1	1	1	2
1x31	1x32	neurotensin_off	1.53	0	0	1	2	2
6x53	6x57	neurotensin_off	1.52	0	0	0	2	1
Lig	NT	neurotensin_on	0	11.39	1	1	0	1
7x31	Lig	neurotensin_on	0	5.905	0	1	1	0
E1	Lig	neurotensin_on	0	6.345	4	1	1	0
E2	Lig	neurotensin_on	0	13.88	4	1	1	0
2x64	Lig	neurotensin_on	0	4.395	0	1	1	0
3x29	Lig	neurotensin_on	0	5.86	0	1	1	0
4x65	Lig	neurotensin_on	0	4.945	0	1	1	0
6x55	Lig	neurotensin_on	0	7.895	1	1	1	0
E2	NT	neurotensin_on	0	19.075	4	1	1	1
E1	NT	neurotensin_on	0	25.285	4	1	1	1
NT	NT	neurotensin_on	0	4.405	0	1	1	1
7x27	NT	neurotensin_on	0	3.81	1	1	1	1
7x31	NT	neurotensin_on	0	19.375	0	1	1	1
1x32	NT	neurotensin_on	0	5.255	0	1	2	1
7x32	NT	neurotensin_on	0	14.635	0	1	2	1
1x31	7x32	neurotensin_on	0	3.82	0	1	2	2
2x60	2x64	neurotensin_on	0	6.415	1	1	2	1
2x60	3x28	neurotensin_on	0	3.93	1	1	2	2
2x60	7x34	neurotensin_on	0	4.49	1	1	2	1
2x64	3x29	neurotensin_on	0	3.61	0	1	1	1
2x64	7x34	neurotensin_on	0	7.74	0	1	1	1
3x21	E1x50	neurotensin_on	0	3.515	0	0	2	2
3x25	E2	neurotensin_on	0	3.545	3	1	2	1
3x32	6x51	neurotensin_on	0	6.175	0	1	2	2
5x36	E2x52	neurotensin_on	0	5.115	0	0	2	2
6x54	7x30	neurotensin_on	0	9.26	1	1	1	1
6x54	7x33	neurotensin_on	0	5.34	1	1	1	2
6x58	7x30	neurotensin_on	0	7.22	0	1	1	1
6x61	E3	neurotensin_on	0	18.22	0	0	2	1
E3	E3	neurotensin_on	0	11.02	1	1	1	1
7x26	E3	neurotensin_on	0	3.42	0	1	2	1
7x27	7x31	neurotensin_on	0	15.54	1	1	1	1
7x30	7x31	neurotensin_on	0	4.355	1	1	1	1
1x30	NT	neurotensin_on	0	3.45	0	0	2	1
1x31	NT	neurotensin_on	0	3.68	0	1	2	1
E1x50	E2	neurotensin_on	0	15.375	3	1	2	1
3x29	3x32	neurotensin_on	0	4.115	0	1	1	2
3x32	6x55	neurotensin_on	0	5.865	0	1	2	1
3x26	E2	neurotensin_on	0	3	0	1	2	1
7x28	NT	neurotensin_on	0	2.19	0	0	2	1
6x56	6x57	neurotensin_on	0	2.12	0	0	2	1
6x53	7x33	neurotensin_on	0	1.965	0	0	2	2
7x29	7x33	neurotensin_on	0	1.07	0	0	2	2
5x34	E2	neurotensin_on	0	0.77	0	1	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	neurotensin_off	nts1_off
	neurotensin_on	nts1_on

Network Difference
Value	neurotensin_off	neurotensin_on
I_min	2.96	3.155
Number of Linked Nodes	256	274
Number of Specific Nodes	6 (2.34%)	24 (8.76%)
Number of Shared Nodes	250 (97.66%)	250 (91.24%)
Number of Links	296	313
Number of Specific Links	143 (48.31%)	160 (51.12%)
Number of Shared Links	153 (51.69%)	153 (48.88%)
Number of Hubs	44	37
Number of Specific Hubs	24 (54.55%)	17 (45.95%)
Number of Shared Hubs	20 (45.45%)	20 (54.05%)
Average % Shared Neighbours (Jaccard)	36.70
Average % Shared Neighbours (Otsuka)	46.30
Average % Shared Neighbours (Overlap Coefficient)	56.13
Average % Shared Cliques (k3-6)	52.72
Graphlets Similarity	0.618575

Paths Difference
Value	neurotensin_off	neurotensin_on
Number Of Nodes in MetaPath	55	56
Specific Nodes in MetaPath	30 (54.55%)	31 (55.36%)
Shared Nodes in MetaPath	250 (97.66%)	250 (97.66%)
Number Of Links MetaPath	56	56
Specific Links in MetaPath	43 (76.79%)	43 (76.79%)
Shared Links in MetaPath	153 (51.69%)	153 (51.69%)
Number of Shortest Paths	66264	61310
Length Of Smallest Path	3	3
Average Path Length	15.8683	14.6973
Length of Longest Path	32	35
Minimum Path Strength	1.295	0.63
Average Path Strength	6.05968	5.56999
Maximum Path Strength	21.58	26.91
Minimum Path Correlation	0.7	0.7
Average Path Correlation	0.9332	0.936799
Maximum Path Correlation	0.99	0.99
Minimum % Of Corr. Nodes	3.84615	3.33333
Average % Of Corr. Nodes	47.5072	51.0023
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	39.9957	47.2581
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

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