psnGPCR

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Orange: nodes, hubs and links specific of nk1_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of nk1_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	nk1_off Int. Strength	nk1_on Int. Strength	nk1_off Hub1?	nk1_on Hub1?	nk1_off Hub2?	nk1_on Hub2?	ConSurf1	ConSurf2
1	3x32	Lig	nk1_off	10.97	0	No	Yes	Yes	Yes	6	0
2	3x36	Lig	nk1_off	3.3225	0	Yes	No	Yes	Yes	7	0
3	E2x52	Lig	nk1_off	3.995	0	Yes	No	Yes	Yes	4	0
4	5x40	Lig	nk1_off	16.3425	0	Yes	No	Yes	Yes	5	0
5	5x43	Lig	nk1_off	3.8775	0	Yes	No	Yes	Yes	5	0
6	5x461	Lig	nk1_off	4.99	0	Yes	No	Yes	Yes	6	0
7	6x48	Lig	nk1_off	5.7075	0	Yes	Yes	Yes	Yes	8	0
8	6x52	Lig	nk1_off	5.6375	0	Yes	Yes	Yes	Yes	7	0
9	7x42	Lig	nk1_off	3.815	0	No	Yes	Yes	Yes	7	0
10	1x35	7x39	nk1_off	3.28	0	Yes	No	Yes	Yes	4	5
11	1x39	7x38	nk1_off	6.285	0	No	No	No	Yes	7	5
12	1x50	2x47	nk1_off	4.69	0	Yes	Yes	No	No	9	9
13	1x53	7x53	nk1_off	5.05	0	No	No	Yes	No	8	9
14	1x54	2x44	nk1_off	3.8	0	No	No	No	No	7	6
15	1x56	8x54	nk1_off	4.0825	0	No	Yes	No	No	8	6
16	I1x48	I1x51	nk1_off	7.4275	0	No	No	No	No	6	6
17	2x40	I1x50	nk1_off	4.9075	0	No	No	Yes	No	8	7
18	8x50	I1x50	nk1_off	4.045	0	Yes	Yes	Yes	No	9	7
19	2x41	I1x51	nk1_off	6.4275	0	Yes	No	No	No	5	6
20	2x38	3x49	nk1_off	5.11	0	No	Yes	Yes	No	6	9
21	2x39	3x46	nk1_off	6.345	0	No	No	No	No	8	9
22	2x39	3x49	nk1_off	3.255	0	No	No	Yes	No	8	9
23	2x41	4x39	nk1_off	4.69	0	Yes	No	No	No	5	2
24	2x42	3x46	nk1_off	3.275	0	Yes	Yes	No	No	7	9
25	2x46	3x43	nk1_off	3.3775	0	No	No	No	No	9	8
26	2x50	3x39	nk1_off	6.11	0	Yes	Yes	No	No	9	9
27	2x53	2x57	nk1_off	3.8575	0	No	Yes	Yes	Yes	7	6
28	2x55	2x56	nk1_off	4.16	0	No	No	No	No	4	5
29	2x57	3x27	nk1_off	6.3425	0	Yes	Yes	No	Yes	6	4
30	2x57	3x31	nk1_off	6.9475	0	Yes	Yes	No	Yes	6	4
31	2x67	E1x51	nk1_off	7.0775	0	No	No	Yes	No	5	2
32	E1x49	E2.R177	nk1_off	9.8875	0	No	No	No	No	4	2
33	3x24	E1x50	nk1_off	4.3425	0	No	No	Yes	Yes	5	8
34	E1x51	E1x52	nk1_off	5.7075	0	Yes	No	Yes	Yes	2	7
35	3x28	3x29	nk1_off	6.3775	0	No	Yes	Yes	No	5	5
36	3x29	4x61	nk1_off	5.28	0	Yes	No	Yes	Yes	5	6
37	3x29	E2x52	nk1_off	9.205	0	Yes	No	Yes	No	5	4
38	3x30	4x57	nk1_off	5.55	0	No	No	No	No	6	7
39	3x30	4x62	nk1_off	3.765	0	No	No	No	No	6	5
40	3x33	5x43	nk1_off	4.61	0	Yes	Yes	Yes	No	5	5
41	3x36	5x461	nk1_off	4.8475	0	Yes	No	Yes	No	7	6
42	3x37	3x41	nk1_off	18.31	0	Yes	No	Yes	No	7	5
43	3x37	4x53	nk1_off	5.55	0	Yes	No	No	No	7	8
44	3x40	3x41	nk1_off	3.63	0	No	No	Yes	No	7	5
45	3x40	5x50	nk1_off	6.7725	0	No	No	No	No	7	9
46	3x41	5x50	nk1_off	6.26	0	Yes	No	No	No	5	9
47	3x47	5x54	nk1_off	4.0625	0	No	No	No	No	9	8
48	3x49	3x50	nk1_off	6.8525	0	Yes	No	No	No	9	9
49	3x50	3x53	nk1_off	4.495	0	No	No	No	No	9	8
50	3x52	I2.R141	nk1_off	3.72	0	No	No	No	Yes	5	5
51	3x53	I2.R141	nk1_off	5.1825	0	No	No	No	Yes	8	5
52	4x42	I2.L142	nk1_off	3.315	0	Yes	Yes	No	No	7	6
53	4x56	5x46	nk1_off	5.19	0	No	No	No	No	5	4
54	4x64	E2.W184	nk1_off	7.4775	0	No	No	Yes	Yes	5	5
55	4x65	E2x52	nk1_off	4.2575	0	No	No	Yes	No	5	4
56	E2.E172	E2.E183	nk1_off	6.98	0	No	No	No	No	3	3
57	E2.E183	E2x51	nk1_off	5.7425	0	No	No	No	No	3	4
58	E2.P185	E2.W184	nk1_off	3.375	0	Yes	No	Yes	Yes	4	5
59	5x31	E2.H187	nk1_off	4.5775	0	No	No	No	No	1	2
60	5x40	5x44	nk1_off	3.425	0	Yes	No	No	No	5	6
61	5x40	6x56	nk1_off	5.145	0	Yes	No	No	No	5	5
62	5x54	6x41	nk1_off	7.68	0	No	No	No	No	8	8
63	5x58	6x38	nk1_off	5.745	0	No	Yes	No	No	9	5
64	5x65	6x31	nk1_off	4.8575	0	No	No	No	No	8	5
65	6x36	7x53	nk1_off	4.79	0	No	Yes	Yes	No	8	9
66	6x36	8x47	nk1_off	4.9075	0	No	Yes	No	No	8	8
67	6x39	7x52	nk1_off	6.1425	0	No	No	No	No	5	8
68	6x40	7x49	nk1_off	8.13	0	Yes	No	No	No	7	9
69	6x40	7x52	nk1_off	4.61	0	Yes	No	No	No	7	8
70	6x47	7x45	nk1_off	3.87	0	No	No	No	No	8	9
71	6x49	6x50	nk1_off	3.28	0	No	No	No	No	5	9
72	6x50	7x40	nk1_off	3.28	0	No	No	No	No	9	7
73	6x57	6x58	nk1_off	4.105	0	No	No	No	No	4	4
74	7x29	7x32	nk1_off	10.25	0	No	No	No	No	3	1
75	7x39	7x43	nk1_off	9.575	0	Yes	Yes	No	No	5	5
76	7x47	7x48	nk1_off	5.9875	0	No	No	No	No	7	5
77	8x47	8x49	nk1_off	3.9175	0	No	No	No	No	8	6
78	2x64	E1x51	nk1_off	3.475	0	No	Yes	Yes	No	4	2
79	5x36	Lig	nk1_off	4.31	0	Yes	No	Yes	Yes	4	0
80	E3.D276	E3.Y278	nk1_off	4.31	0	No	No	No	No	1	0
81	5x61	6x34	nk1_off	3.2075	0	No	No	No	No	8	6
82	8x56	CT.R321	nk1_off	3.1025	0	No	No	No	No	3	5
83	3x48	5x57	nk1_off	3.085	0	No	No	No	No	5	7
84	6x37	6x40	nk1_off	3.0425	0	No	Yes	Yes	No	8	7
85	3x43	6x40	nk1_off	3.04	0	No	No	Yes	No	8	7
86	6x43	7x52	nk1_off	3.04	0	No	No	No	No	6	8
87	5x31	5x34	nk1_off	2.9625	0	No	No	No	No	1	1
88	3x25	E2.T171	nk1_off	2.9575	0	No	No	No	No	9	5
89	3x54	3x55	nk1_off	2.94	0	No	No	Yes	Yes	8	7
90	8x55	CT.I326	nk1_off	2.9075	0	No	No	No	No	5	6
91	CT.C323	CT.P324	nk1_off	2.825	0	No	No	No	No	5	3
92	3x47	5x57	nk1_off	2.81	0	No	No	No	No	9	7
93	4x41	I2.L142	nk1_off	2.7575	0	No	No	No	No	4	6
94	7x33	7x37	nk1_off	2.6875	0	No	No	No	No	5	6
95	7x32	NT.Q27	nk1_off	2.56	0	No	No	No	Yes	1	4
96	2x53	3x35	nk1_off	2.415	0	No	Yes	No	No	7	8
97	CT.?322	CT.C323	nk1_off	2.3675	0	No	No	No	No	9	5
98	5x61	5x62	nk1_off	2.3	0	No	No	No	No	8	5
99	1x51	1x54	nk1_off	2.28	0	No	No	No	No	4	7
100	5x49	5x53	nk1_off	2.235	0	No	No	No	No	5	6
101	5x36	E2.E183	nk1_off	2.22	0	Yes	No	No	No	4	3
102	3x22	E2.T170	nk1_off	2.2125	0	No	No	No	No	3	4
103	E2.E172	E2.V179	nk1_off	2.14	0	No	No	No	No	3	3
104	3x37	4x52	nk1_off	2.135	0	Yes	No	No	No	7	4
105	8x57	8x58	nk1_off	2.0775	0	No	No	No	No	4	6
106	5x68	6x27	nk1_off	2.0225	0	No	No	No	No	5	2
107	7x55	7x56	nk1_off	1.985	0	No	No	No	No	6	7
108	6x27	6x31	nk1_off	1.9625	0	No	No	No	No	2	5
109	6x28	6x32	nk1_off	1.9125	0	No	No	No	No	4	8
110	E2.E186	E2.W184	nk1_off	1.9075	0	No	No	Yes	Yes	3	5
111	5x41	6x59	nk1_off	1.815	0	No	No	No	No	5	5
112	CT.?322	CT.R321	nk1_off	1.8125	0	No	No	No	No	9	5
113	1x34	1x35	nk1_off	1.7075	0	No	No	Yes	No	4	4
114	2x65	7x34	nk1_off	1.6675	0	No	No	No	Yes	5	5
115	6x58	E3.L277	nk1_off	1.6425	0	No	No	No	Yes	4	5
116	6x58	E3.D276	nk1_off	1.61	0	No	No	No	No	4	1
117	3x23	3x24	nk1_off	1.5475	0	No	No	No	No	3	5
118	2x67	7x31	nk1_off	1.545	0	No	No	No	No	5	4
119	3x56	I2.P137	nk1_off	1.53	0	Yes	Yes	No	No	6	8
120	7x30	E3.K280	nk1_off	1.455	0	No	No	No	No	4	4
121	6x53	6x57	nk1_off	1.425	0	No	No	No	No	6	4
122	7x30	E3.L277	nk1_off	1.425	0	No	No	No	Yes	4	5
123	CT.C323	CT.F325	nk1_off	1.3975	0	No	No	No	No	5	3
124	E3.L277	E3.L279	nk1_off	1.385	0	No	Yes	No	No	5	2
125	1x47	2x55	nk1_off	1.275	0	No	No	No	No	6	4
126	6x38	6x42	nk1_off	1.23	0	No	No	No	No	5	4
127	1x45	7x51	nk1_off	1.14	0	Yes	No	No	No	4	7
128	6x57	6x60	nk1_off	1.07	0	No	No	No	No	4	5
129	6x35	7x56	nk1_off	1.0575	0	No	No	No	No	6	7
130	5x63	5x66	nk1_off	0.9375	0	No	No	No	No	3	4
131	1x37	1x40	nk1_off	0.84	0	No	No	No	No	5	4
132	4x43	4x47	nk1_off	0.8075	0	No	No	No	No	2	3
133	6x25	6x28	nk1_off	0.7175	0	No	No	No	No	3	4
134	4x54	4x55	nk1_off	0.6925	0	No	No	No	No	4	4
135	CT.F325	CT.I326	nk1_off	0.6275	0	No	No	No	No	3	6
136	5x55	5x59	nk1_off	0.455	0	No	No	No	No	4	3
137	6x29	6x32	nk1_off	0.4025	0	No	No	No	No	5	8
138	1x32	1x33	nk1_off	0.385	0	No	No	No	No	3	4
139	6x32	8x48	nk1_off	0.345	0	No	No	No	No	8	4
140	3x33	Lig	Shared	7.3725	14.97	Yes	Yes	Yes	Yes	5	0
141	4x61	Lig	Shared	16.56	9.52	Yes	Yes	Yes	Yes	6	0
142	6x51	Lig	Shared	18.08	7.46	Yes	Yes	Yes	Yes	7	0
143	6x55	Lig	Shared	17.67	13.95	No	No	Yes	Yes	6	0
144	1x31	NT.Q27	Shared	3.52	7.68	No	No	No	Yes	2	4
145	1x28	1x30	Shared	6.4175	9.46	No	No	No	No	2	1
146	1x28	1x31	Shared	12.6325	14.21	No	No	No	No	2	2
147	1x30	1x31	Shared	11.5	14.24	No	No	No	No	1	2
148	1x32	2x66	Shared	4.2225	6.14	No	No	No	Yes	3	5
149	1x35	7x35	Shared	9.1125	18.22	Yes	No	No	No	4	3
150	1x38	7x39	Shared	3.89	3.89	No	No	Yes	Yes	4	5
151	1x39	2x62	Shared	11.0875	16.5	No	No	No	No	7	6
152	1x39	7x39	Shared	10.13	6.75	No	No	Yes	Yes	7	5
153	1x42	7x39	Shared	11.7425	17.62	No	No	Yes	Yes	7	5
154	1x43	2x58	Shared	3.57	3.17	No	No	No	No	6	7
155	1x45	7x47	Shared	10.915	7.53	Yes	No	No	No	4	7
156	1x46	1x50	Shared	3.725	4.47	No	No	Yes	Yes	8	9
157	1x46	7x46	Shared	6.7975	7.99	No	No	No	No	8	9
158	1x48	1x49	Shared	3.68	3.68	No	No	No	No	4	8
159	1x49	7x50	Shared	4.06	4.06	No	No	No	No	8	9
160	1x50	2x50	Shared	3.94	7.89	Yes	Yes	Yes	Yes	9	9
161	1x50	2x51	Shared	5.08	4.69	Yes	Yes	No	No	9	7
162	1x50	7x50	Shared	10.9925	8.15	Yes	Yes	No	No	9	9
163	1x52	8x54	Shared	7.8675	14.42	No	No	No	No	6	6
164	1x55	1x59	Shared	4.8625	10.37	Yes	Yes	No	No	4	4
165	1x55	1x60	Shared	6.0825	6.35	Yes	Yes	No	Yes	4	5
166	1x55	8x56	Shared	3.7025	5.29	Yes	Yes	No	No	4	3
167	1x56	8x50	Shared	4.08	6.28	No	Yes	Yes	Yes	8	9
168	1x56	8x53	Shared	4.41	3.53	No	Yes	No	No	8	6
169	1x57	2x40	Shared	10.6175	7.08	No	No	No	No	7	8
170	1x57	2x44	Shared	6.91	3.07	No	No	No	No	7	6
171	1x57	8x50	Shared	5.02	3.77	No	No	Yes	Yes	7	9
172	1x58	2x44	Shared	3.725	2.98	No	No	No	No	2	6
173	1x60	I1x50	Shared	3.94	5.25	No	Yes	Yes	No	5	7
174	8x49	I1x49	Shared	3.465	5.33	No	No	No	No	6	5
175	8x49	I1x50	Shared	4.34	3.72	No	No	Yes	No	6	7
176	2x37	2x40	Shared	8.0425	5.85	No	No	No	No	7	8
177	2x38	4x42	Shared	6.3475	4.76	No	Yes	Yes	Yes	6	7
178	2x41	4x42	Shared	4.0575	4.99	Yes	No	Yes	Yes	5	7
179	2x41	4x43	Shared	4.48	8.36	Yes	No	No	No	5	2
180	2x42	3x45	Shared	8.6675	8.32	Yes	Yes	No	No	7	7
181	2x42	4x42	Shared	5.19	5.19	Yes	Yes	Yes	Yes	7	7
182	2x42	4x45	Shared	5.24	6.55	Yes	Yes	No	No	7	5
183	2x42	4x46	Shared	5.335	3.77	Yes	Yes	No	No	7	8
184	2x43	7x53	Shared	7.91	10.55	No	No	Yes	No	8	9
185	2x45	3x42	Shared	7.0775	5.96	No	No	No	No	9	8
186	2x45	4x46	Shared	13.0975	14.16	No	No	No	No	9	8
187	2x45	4x50	Shared	9.04	7.91	No	No	Yes	Yes	9	9
188	2x48	2x52	Shared	6.9375	7.93	No	No	No	No	6	6
189	2x48	4x50	Shared	3.505	4.01	No	No	Yes	Yes	6	9
190	2x50	7x46	Shared	5.6425	9.88	Yes	Yes	No	No	9	9
191	2x50	7x49	Shared	9.2025	11.83	Yes	Yes	No	No	9	9
192	2x53	3x36	Shared	3.2775	4.56	No	Yes	Yes	No	7	7
193	2x57	2x61	Shared	3.405	5.45	Yes	Yes	No	Yes	6	6
194	2x57	3x32	Shared	7.735	4.89	Yes	Yes	No	Yes	6	6
195	2x58	7x42	Shared	7.905	9.03	No	No	No	Yes	7	7
196	2x60	E1x52	Shared	3.4725	15.14	No	No	Yes	Yes	5	7
197	2x60	3x24	Shared	9.465	6.31	No	No	No	No	5	5
198	2x61	3x28	Shared	8.925	12.75	No	Yes	No	Yes	6	5
199	2x62	2x66	Shared	3.93	7.87	No	No	No	Yes	6	5
200	2x63	E1x52	Shared	4.3675	6.24	No	No	Yes	Yes	4	7
201	2x64	E1x50	Shared	10.61	11.58	No	Yes	Yes	Yes	4	8
202	2x67	E1x49	Shared	7.695	6.15	No	No	No	No	5	4
203	E1x49	E1x51	Shared	10.3825	17.96	No	No	Yes	No	4	2
204	E1x50	E1x52	Shared	11.09	15.43	Yes	Yes	Yes	Yes	8	7
205	3x25	E1x50	Shared	4.57	5.22	No	No	Yes	Yes	9	8
206	3x28	E1x50	Shared	8.2025	4.23	No	Yes	Yes	Yes	5	8
207	E1x50	E2x50	Shared	11.1025	10.45	Yes	Yes	No	No	8	9
208	3x22	3x26	Shared	3.525	5.64	No	No	No	No	3	6
209	3x22	E2.T171	Shared	3.685	11.79	No	No	No	No	3	5
210	3x25	E2x50	Shared	7.28	7.28	No	No	No	No	9	9
211	3x27	3x31	Shared	14.47	7.5	No	Yes	No	Yes	4	4
212	3x29	4x65	Shared	6.3325	5.96	Yes	No	No	No	5	5
213	3x30	4x54	Shared	4.26	7.31	No	No	No	No	6	4
214	3x33	4x57	Shared	3.25	3.25	Yes	Yes	No	No	5	7
215	3x33	4x61	Shared	5.1475	5.49	Yes	Yes	Yes	Yes	5	6
216	3x36	6x48	Shared	6.5	4.9	Yes	No	Yes	Yes	7	8
217	3x37	5x461	Shared	3.77	11.3	Yes	No	Yes	No	7	6
218	3x38	4x50	Shared	9.0775	9.08	No	No	Yes	Yes	7	9
219	3x40	6x44	Shared	11.3025	7.54	No	No	No	No	7	9
220	3x44	5x54	Shared	7.6	6.08	No	No	No	No	7	8
221	3x47	5x58	Shared	7.005	5.34	No	No	No	Yes	9	9
222	3x48	3x52	Shared	4.0425	8.71	No	No	No	No	5	5
223	3x49	I2.R141	Shared	7.1475	10.72	Yes	No	No	Yes	9	5
224	3x51	3x55	Shared	16.3175	13.3	Yes	Yes	Yes	Yes	8	7
225	3x51	3x56	Shared	5.4425	4.36	Yes	Yes	Yes	Yes	8	6
226	3x51	5x56	Shared	6.455	4.96	Yes	Yes	No	No	8	4
227	3x51	5x57	Shared	5.8625	4	Yes	Yes	No	No	8	7
228	3x51	5x60	Shared	5.6775	8.83	Yes	Yes	No	No	8	4
229	3x54	5x61	Shared	3.455	12.29	No	No	No	No	8	8
230	3x54	5x65	Shared	3.925	4.28	No	No	No	No	8	8
231	3x55	3x56	Shared	10.2775	10.61	Yes	Yes	Yes	Yes	7	6
232	3x55	5x64	Shared	4.56	4.56	Yes	Yes	No	No	7	5
233	3x56	I2.Q139	Shared	11.1275	2.47	Yes	Yes	No	No	6	4
234	4x38	4x41	Shared	3.42	1.71	No	No	No	No	7	4
235	4x56	5x43	Shared	3.725	4.47	No	No	Yes	No	5	5
236	4x59	4x60	Shared	7.9425	4.33	No	No	No	No	4	8
237	4x59	4x63	Shared	6.445	7.22	No	No	No	No	4	4
238	4x60	5x39	Shared	11.1275	8.34	No	No	Yes	Yes	8	6
239	4x61	E2x52	Shared	6.5175	6.86	Yes	Yes	Yes	No	6	4
240	4x61	E2.W184	Shared	3.56	6.57	Yes	Yes	Yes	Yes	6	5
241	4x61	5x39	Shared	9.58	15.78	Yes	Yes	Yes	Yes	6	6
242	4x63	4x64	Shared	9.93	10.92	No	No	No	No	4	5
243	4x64	E2.P185	Shared	8.345	15.3	No	No	Yes	No	5	4
244	E2.E172	E2.M174	Shared	3.72	6.77	No	No	No	No	3	1
245	E2.R177	E2.S176	Shared	4.9425	11.86	No	No	No	No	2	5
246	E2.W184	E2x52	Shared	6.7525	17.62	Yes	Yes	Yes	No	5	4
247	5x36	E2.W184	Shared	16.085	18.54	Yes	No	Yes	Yes	4	5
248	5x39	E2.W184	Shared	6.27	13.5	Yes	Yes	Yes	Yes	6	5
249	E2.H187	E2.P185	Shared	3.4325	4.58	No	No	Yes	No	2	4
250	5x33	5x36	Shared	7.0875	12.15	No	No	Yes	No	2	4
251	5x37	6x59	Shared	10.155	2.39	No	No	No	No	3	5
252	5x39	5x43	Shared	6.6225	6.31	Yes	Yes	Yes	No	6	5
253	5x40	6x59	Shared	7.6225	15.24	Yes	No	No	No	5	5
254	5x44	6x52	Shared	9.24	12.32	No	No	Yes	Yes	6	7
255	5x44	6x56	Shared	3.6825	5.9	No	No	No	No	6	5
256	5x461	6x52	Shared	4.3075	5.3	Yes	No	Yes	Yes	6	7
257	5x47	5x48	Shared	12.635	7.22	Yes	Yes	No	No	8	4
258	5x47	5x51	Shared	8.5025	4.69	Yes	Yes	No	No	8	6
259	5x47	6x49	Shared	6.445	9.38	Yes	Yes	No	No	8	5
260	5x47	6x52	Shared	7.6225	9.8	Yes	Yes	Yes	Yes	8	7
261	5x49	5x50	Shared	3.28	3.28	No	No	No	No	5	9
262	5x56	5x60	Shared	6.94	8.83	No	No	No	No	4	4
263	5x58	6x37	Shared	6.2875	21.55	No	Yes	No	Yes	9	8
264	5x66	6x31	Shared	9.0125	33.99	No	No	No	No	4	5
265	6x36	7x56	Shared	7.07	5.65	No	Yes	No	No	8	7
266	6x43	7x48	Shared	4.99	4.99	No	No	No	No	6	5
267	6x44	6x48	Shared	9.77	8.02	No	No	Yes	Yes	9	8
268	6x47	7x40	Shared	4.7625	4.76	No	No	No	No	8	7
269	6x48	6x51	Shared	8.7675	11.02	Yes	Yes	Yes	Yes	8	7
270	6x48	7x41	Shared	5.835	7.78	Yes	Yes	No	No	8	7
271	6x48	7x45	Shared	7.1025	4.94	Yes	Yes	No	No	8	9
272	6x49	6x53	Shared	4.64	7.14	No	No	No	No	5	6
273	6x50	7x37	Shared	4.235	3.39	No	No	No	No	9	6
274	6x51	6x55	Shared	8.8425	11.79	Yes	Yes	No	No	7	6
275	6x51	7x41	Shared	4.5075	4.16	Yes	Yes	No	No	7	7
276	6x54	6x55	Shared	8.8425	10.72	Yes	Yes	No	No	4	6
277	6x54	7x34	Shared	8.2525	9.28	Yes	Yes	No	Yes	4	5
278	6x54	7x37	Shared	3.765	7.54	Yes	Yes	No	No	4	6
279	6x61	E3.P275	Shared	3.6675	1.63	No	Yes	No	No	4	3
280	7x34	7x38	Shared	7.7825	11.97	No	Yes	No	Yes	5	5
281	7x43	7x48	Shared	8.9	7.63	No	No	No	No	5	5
282	7x49	7x53	Shared	6.3975	10.47	No	No	Yes	No	9	9
283	7x53	8x50	Shared	9.5425	6.19	Yes	No	Yes	Yes	9	9
284	7x54	8x54	Shared	6.9825	8.38	No	No	No	No	7	6
285	8x47	8x50	Shared	11.175	7.25	No	No	Yes	Yes	8	9
286	E2.M174	E2.P175	Shared	3.3525	6.71	No	No	No	No	1	2
287	5x32	5x34	Shared	3.54	11.33	No	No	No	No	3	1
288	8x48	8x51	Shared	3.5725	9.53	No	No	No	No	4	8
289	4x38	4x40	Shared	3.2	1.6	No	No	No	No	7	4
290	5x65	6x30	Shared	3.0675	5.64	No	No	No	No	8	7
291	3x41	4x49	Shared	3.025	3.63	Yes	No	No	No	5	7
292	5x35	E2.P185	Shared	2.7825	5.56	No	No	Yes	No	4	4
293	E2.T171	E2.V178	Shared	2.7775	1.59	No	No	No	No	5	4
294	5x51	6x45	Shared	2.7575	3.15	No	No	No	No	6	5
295	6x61	E3.D276	Shared	2.6925	4.04	No	Yes	No	No	4	1
296	4x48	4x52	Shared	2.6075	2.98	No	No	No	No	3	4
297	2x49	4x50	Shared	2.59	2.59	No	No	Yes	Yes	8	9
298	1x46	2x54	Shared	2.565	3.42	No	No	No	No	8	6
299	1x43	2x59	Shared	2.405	4.81	No	No	No	No	6	8
300	1x55	8x57	Shared	2.2675	3.89	Yes	Yes	No	No	4	4
301	2x56	3x27	Shared	2.1425	5.36	No	No	No	Yes	5	4
302	2x68	E2.R177	Shared	2.11	13.26	No	Yes	No	No	4	2
303	1x36	2x62	Shared	2.0775	2.77	No	No	No	No	6	6
304	E2.T173	E2.V178	Shared	1.985	6.35	No	No	No	No	2	4
305	1x35	7x36	Shared	1.945	2.59	Yes	No	No	No	4	5
306	5x59	5x63	Shared	1.9	3.04	No	No	No	No	3	3
307	3x34	4x53	Shared	1.79	1.79	No	No	No	No	5	8
308	7x54	8x51	Shared	1.7425	1.39	No	No	No	No	7	8
309	1x44	1x45	Shared	1.59	1.59	No	No	Yes	No	4	4
310	I2.P140	I2.Q139	Shared	1.58	3.16	No	No	No	No	6	4
311	6x54	7x30	Shared	1.57	5.02	Yes	Yes	No	No	4	4
312	5x34	5x38	Shared	1.5375	3.07	No	No	No	No	1	4
313	4x51	4x55	Shared	1.49	2.98	No	No	No	No	3	4
314	1x30	1x34	Shared	1.425	2.28	No	No	No	No	1	4
315	3x21	E1x50	Shared	1.4075	2.81	No	No	Yes	Yes	8	8
316	5x38	5x42	Shared	1.2825	1.71	No	No	No	No	4	4
317	4x44	4x48	Shared	1.2	1.6	No	No	No	No	3	3
318	1x41	1x45	Shared	1.1925	1.59	No	No	Yes	No	5	4
319	5x41	5x45	Shared	1.155	1.54	No	No	No	No	5	4
320	1x40	1x44	Shared	0.3975	1.59	No	No	No	No	4	4
321	6x33	6x37	Shared	0.38	3.04	No	No	No	Yes	7	8
322	8x52	8x55	Shared	0.3525	4.23	No	No	No	No	4	5
323	NT.F25	NT.N23	nk1_on	0	8.46	No	Yes	No	Yes	0	0
324	NT.N23	NT.V26	nk1_on	0	5.91	No	Yes	No	No	0	0
325	2x68	NT.N23	nk1_on	0	4.09	No	Yes	No	Yes	4	0
326	E2.R177	NT.N23	nk1_on	0	14.46	No	No	No	Yes	2	0
327	NT.F25	NT.Q24	nk1_on	0	14.05	No	Yes	No	No	0	0
328	7x28	NT.Q24	nk1_on	0	8.14	No	No	No	No	2	0
329	2x68	NT.F25	nk1_on	0	8.46	No	Yes	No	Yes	4	0
330	7x31	NT.F25	nk1_on	0	9.37	No	No	No	Yes	4	0
331	Lig	NT.F25	nk1_on	0	16.08	Yes	Yes	No	Yes	0	0
332	2x67	NT.V26	nk1_on	0	6.92	No	No	No	No	5	0
333	1x32	NT.Q27	nk1_on	0	8.23	No	No	No	Yes	3	4
334	2x66	NT.Q27	nk1_on	0	4.3	No	Yes	No	Yes	5	4
335	7x31	NT.Q27	nk1_on	0	10.24	No	No	No	Yes	4	4
336	1x35	7x32	nk1_on	0	6.57	Yes	No	No	No	4	1
337	1x39	7x35	nk1_on	0	4.69	No	No	No	No	7	3
338	1x53	8x50	nk1_on	0	6.55	No	No	Yes	Yes	8	9
339	1x56	1x60	nk1_on	0	5.3	No	Yes	No	Yes	8	5
340	1x56	I1x50	nk1_on	0	4.37	No	Yes	Yes	No	8	7
341	1x58	I1x51	nk1_on	0	8.5	No	No	No	No	2	6
342	1x59	1x60	nk1_on	0	7.32	No	No	No	Yes	4	5
343	1x60	8x56	nk1_on	0	5.97	No	Yes	No	No	5	3
344	2x37	2x39	nk1_on	0	4.71	No	No	No	No	7	8
345	2x38	2x41	nk1_on	0	6.31	No	Yes	Yes	No	6	5
346	2x38	I2.R141	nk1_on	0	10.46	No	Yes	No	Yes	6	5
347	2x42	3x49	nk1_on	0	8.36	Yes	Yes	Yes	No	7	9
348	2x46	2x50	nk1_on	0	6.63	No	No	Yes	Yes	9	9
349	2x46	3x42	nk1_on	0	4.5	No	No	No	No	9	8
350	2x46	7x49	nk1_on	0	8.24	No	No	No	No	9	9
351	2x53	3x39	nk1_on	0	4.6	No	Yes	No	No	7	9
352	2x53	7x42	nk1_on	0	4.33	No	Yes	No	Yes	7	7
353	2x53	7x46	nk1_on	0	4.52	No	Yes	No	No	7	9
354	2x56	3x31	nk1_on	0	5.36	No	No	No	Yes	5	4
355	2x57	3x28	nk1_on	0	8.93	Yes	Yes	No	Yes	6	5
356	2x57	7x38	nk1_on	0	4.21	Yes	Yes	No	Yes	6	5
357	2x57	7x42	nk1_on	0	4.21	Yes	Yes	No	Yes	6	7
358	2x57	Lig	nk1_on	0	10.2	Yes	Yes	Yes	Yes	6	0
359	2x60	3x28	nk1_on	0	12.45	No	No	No	Yes	5	5
360	2x61	7x34	nk1_on	0	8.14	No	Yes	No	Yes	6	5
361	2x61	7x38	nk1_on	0	5.61	No	Yes	No	Yes	6	5
362	2x61	Lig	nk1_on	0	10.27	No	Yes	Yes	Yes	6	0
363	2x64	2x68	nk1_on	0	6.98	No	Yes	No	Yes	4	4
364	2x64	E2.V179	nk1_on	0	6.31	No	Yes	No	No	4	3
365	2x64	Lig	nk1_on	0	9.99	No	Yes	Yes	Yes	4	0
366	2x66	2x67	nk1_on	0	8.3	No	Yes	No	No	5	5
367	2x68	E2.V179	nk1_on	0	4.43	No	Yes	No	No	4	3
368	2x68	Lig	nk1_on	0	14.5	No	Yes	Yes	Yes	4	0
369	3x24	E1x52	nk1_on	0	11.91	No	No	Yes	Yes	5	7
370	3x24	3x27	nk1_on	0	11.35	No	No	No	Yes	5	4
371	3x26	4x65	nk1_on	0	9.18	No	No	No	No	6	5
372	3x27	3x32	nk1_on	0	4.33	No	Yes	No	Yes	4	6
373	3x28	3x32	nk1_on	0	10.68	No	Yes	No	Yes	5	6
374	3x28	Lig	nk1_on	0	11.5	No	Yes	Yes	Yes	5	0
375	3x29	3x33	nk1_on	0	4.25	Yes	No	Yes	Yes	5	5
376	3x29	Lig	nk1_on	0	8.24	Yes	No	Yes	Yes	5	0
377	3x31	3x32	nk1_on	0	5.78	No	Yes	No	Yes	4	6
378	3x31	4x50	nk1_on	0	5.01	No	Yes	Yes	Yes	4	9
379	3x33	3x37	nk1_on	0	5.02	Yes	Yes	Yes	No	5	7
380	3x37	4x56	nk1_on	0	12.18	Yes	No	No	No	7	5
381	3x40	6x48	nk1_on	0	9.4	No	No	Yes	Yes	7	8
382	3x44	5x53	nk1_on	0	6.35	No	No	No	No	7	6
383	3x48	I2.L142	nk1_on	0	4.87	No	No	No	No	5	6
384	3x50	5x58	nk1_on	0	7.2	No	No	No	Yes	9	9
385	3x52	3x56	nk1_on	0	5.25	No	No	Yes	Yes	5	6
386	3x55	5x60	nk1_on	0	4.61	Yes	Yes	No	No	7	4
387	4x42	I2.R141	nk1_on	0	9.06	Yes	Yes	No	Yes	7	5
388	E2.E183	E2.T170	nk1_on	0	16.93	No	No	No	No	3	4
389	E2.E172	Lig	nk1_on	0	6.29	No	No	Yes	Yes	3	0
390	E2.M174	Lig	nk1_on	0	6.7	No	No	Yes	Yes	1	0
391	E2.V179	Lig	nk1_on	0	10.49	No	No	Yes	Yes	3	0
392	E2x51	Lig	nk1_on	0	8.71	No	No	Yes	Yes	4	0
393	5x40	E2.W184	nk1_on	0	4.23	Yes	No	Yes	Yes	5	5
394	5x34	E2.H187	nk1_on	0	6.63	No	No	No	No	1	2
395	5x36	6x59	nk1_on	0	6.73	Yes	No	No	No	4	5
396	5x39	5x40	nk1_on	0	7.62	Yes	Yes	Yes	No	6	5
397	5x50	6x44	nk1_on	0	4.33	No	No	No	No	9	9
398	5x61	6x37	nk1_on	0	6.09	No	No	No	Yes	8	8
399	5x62	6x34	nk1_on	0	5.52	No	No	No	No	5	6
400	5x66	6x34	nk1_on	0	7.36	No	No	No	No	4	6
401	6x23	6x26	nk1_on	0	4.51	No	No	No	No	0	4
402	6x32	7x56	nk1_on	0	4.23	No	No	No	No	8	7
403	6x36	6x37	nk1_on	0	4.33	No	Yes	No	Yes	8	8
404	6x36	7x52	nk1_on	0	7.29	No	Yes	No	No	8	8
405	6x51	6x52	nk1_on	0	5.66	Yes	Yes	Yes	Yes	7	7
406	6x54	E3.Y278	nk1_on	0	14.44	Yes	Yes	No	No	4	0
407	6x58	E3.Y278	nk1_on	0	16.69	No	No	No	No	4	0
408	6x60	6x61	nk1_on	0	4.25	No	No	No	Yes	5	4
409	6x61	E3.L277	nk1_on	0	4.12	No	Yes	No	Yes	4	5
410	E3.D276	E3.L277	nk1_on	0	4.07	No	No	No	Yes	1	5
411	E3.L279	Lig	nk1_on	0	8.06	No	No	Yes	Yes	2	0
412	7x29	E3.K280	nk1_on	0	8.69	No	No	No	No	3	4
413	7x31	7x32	nk1_on	0	8.96	No	No	No	No	4	1
414	7x34	Lig	nk1_on	0	15.21	No	Yes	Yes	Yes	5	0
415	7x38	7x42	nk1_on	0	5.78	No	Yes	No	Yes	5	7
416	Lig	Lig	nk1_on	0	58.53	Yes	Yes	Yes	Yes	0	0
417	3x46	3x50	nk1_on	0	3.92	No	No	No	No	9	9
418	2x39	I2.R141	nk1_on	0	3.88	No	No	No	Yes	8	5
419	5x58	6x41	nk1_on	0	3.79	No	Yes	No	No	9	8
420	1x54	2x48	nk1_on	0	3.73	No	No	No	No	7	6
421	4x62	4x65	nk1_on	0	3.71	No	No	No	No	5	5
422	5x55	6x41	nk1_on	0	3.68	No	No	No	No	4	8
423	3x41	5x461	nk1_on	0	3.63	Yes	No	Yes	No	5	6
424	5x54	5x58	nk1_on	0	3.63	No	No	No	Yes	8	9
425	3x44	5x50	nk1_on	0	3.5	No	No	No	No	7	9
426	7x39	7x40	nk1_on	0	3.42	Yes	Yes	No	No	5	7
427	1x53	2x47	nk1_on	0	3.39	No	No	No	No	8	9
428	2x38	4x39	nk1_on	0	3.39	No	Yes	No	No	6	2
429	6x43	6x47	nk1_on	0	3.38	No	No	No	No	6	8
430	6x23	6x25	nk1_on	0	3.37	No	No	No	No	0	3
431	5x31	5x32	nk1_on	0	3.26	No	No	No	No	1	3
432	6x32	7x55	nk1_on	0	3.23	No	No	No	No	8	6
433	2x65	7x35	nk1_on	0	3.15	No	No	No	No	5	3
434	3x34	4x54	nk1_on	0	3.15	No	No	No	No	5	4
435	1x52	1x56	nk1_on	0	3.07	No	No	No	Yes	6	8
436	3x55	5x61	nk1_on	0	3.07	Yes	Yes	No	No	7	8
437	7x30	7x33	nk1_on	0	3.07	No	No	No	No	4	5
438	6x36	6x40	nk1_on	0	3.04	No	Yes	Yes	No	8	7
439	5x65	6x34	nk1_on	0	2.98	No	No	No	No	8	6
440	1x42	7x47	nk1_on	0	2.92	No	No	No	No	7	7
441	3x43	5x54	nk1_on	0	2.92	No	No	No	No	8	8
442	6x57	E3.L277	nk1_on	0	2.77	No	No	No	Yes	4	5
443	7x29	7x33	nk1_on	0	2.62	No	No	No	No	3	5
444	7x29	E3.L277	nk1_on	0	2.44	No	No	No	Yes	3	5
445	3x41	5x46	nk1_on	0	2.34	Yes	No	No	No	5	4
446	5x66	6x35	nk1_on	0	2.32	No	No	No	No	4	6
447	4x50	4x54	nk1_on	0	2.28	Yes	Yes	No	No	9	4
448	3x38	4x53	nk1_on	0	1.79	No	No	No	No	7	8
449	2x52	3x35	nk1_on	0	1.71	No	No	No	No	6	8
450	1x47	2x51	nk1_on	0	1.7	No	No	No	No	6	7
451	1x47	1x51	nk1_on	0	1.6	No	No	No	No	6	4
452	6x39	6x43	nk1_on	0	1.59	No	No	No	No	5	6
453	5x37	5x41	nk1_on	0	1.45	No	No	No	No	3	5
454	4x52	4x55	nk1_on	0	1.38	No	No	No	No	4	4
455	8x49	8x52	nk1_on	0	1.21	No	No	No	No	6	4
456	8x51	8x52	nk1_on	0	1.21	No	No	No	No	8	4
457	4x64	E2.E183	nk1_on	0	1.12	No	No	No	No	5	3

Orange: nodes, hubs and links specific of nk1_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of nk1_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	nk1_off Avg Int. Strength	nk1_on Avg Int. Strength	nk1_off Num Of Links	nk1_on Num Of Links	ConSurf
1	1x35	nk1_off	4.01125	9.12667	4	3	4
2	1x45	nk1_off	3.70938	3.57	4	3	4
3	I1x50	nk1_off	4.30813	4.44667	4	3	7
4	2x41	nk1_off	4.91375	6.55333	4	3	5
5	E1x51	nk1_off	6.66063	17.96	4	1	2
6	3x29	nk1_off	6.79875	6.15	4	3	5
7	3x36	nk1_off	4.48688	4.73	4	2	7
8	3x37	nk1_off	7.44125	9.5	4	3	7
9	3x41	nk1_off	7.80625	3.2	4	3	5
10	3x49	nk1_off	5.59125	9.54	4	2	9
11	E2x52	nk1_off	6.1455	12.24	5	2	4
12	E2.P185	nk1_off	4.48375	8.48	4	3	4
13	5x36	nk1_off	7.42562	12.4733	4	3	4
14	5x40	nk1_off	8.13375	9.03	4	3	5
15	5x43	nk1_off	4.70875	5.39	4	2	5
16	5x461	nk1_off	4.47875	6.74333	4	3	6
17	6x40	nk1_off	4.70562	3.04	4	1	7
18	7x53	nk1_off	6.738	9.07	5	3	9
19	Lig	Shared	8.76071	15.7474	14	19	0
20	1x50	Shared	5.6855	6.3	5	4	9
21	1x55	Shared	4.22875	6.475	4	4	4
22	2x42	Shared	5.5415	6.438	5	5	7
23	2x50	Shared	6.22375	9.0575	4	4	9
24	2x57	Shared	5.6575	6.315	5	6	6
25	E1x50	Shared	7.33214	8.28667	7	6	8
26	E1x52	Shared	6.15938	12.18	4	4	7
27	3x33	Shared	5.095	6.596	4	5	5
28	3x51	Shared	7.951	7.09	5	5	8
29	3x55	Shared	8.52375	7.23	4	5	7
30	3x56	Shared	7.09438	5.6725	4	4	6
31	4x42	Shared	4.7275	6	4	4	7
32	4x50	Shared	6.05313	5.14667	4	6	9
33	4x61	Shared	7.77417	8.844	6	5	6
34	E2.W184	Shared	6.48964	12.092	7	5	5
35	5x39	Shared	8.4	10.31	4	5	6
36	5x47	Shared	8.80125	7.7725	4	4	8
37	6x48	Shared	7.28042	7.67667	6	6	8
38	6x51	Shared	10.0494	8.018	4	5	7
39	6x52	Shared	6.70187	8.27	4	4	7
40	6x54	Shared	5.6075	9.4	4	5	4
41	7x39	Shared	7.7235	7.92	5	4	5
42	8x50	Shared	6.7725	6.008	5	5	9
43	NT.N23	nk1_on	0	8.23	0	4	0
44	NT.F25	nk1_on	0	11.284	0	5	0
45	NT.Q27	nk1_on	3.04	7.6125	2	4	4
46	1x56	nk1_on	4.19083	4.51	3	5	8
47	1x60	nk1_on	5.01125	6.038	2	5	5
48	2x38	nk1_on	5.72875	6.23	2	4	6
49	2x53	nk1_on	3.18333	4.5025	3	4	7
50	2x61	nk1_on	6.165	8.444	2	5	6
51	2x64	nk1_on	7.0425	8.715	2	4	4
52	2x66	nk1_on	4.07625	6.6525	2	4	5
53	2x68	nk1_on	2.11	8.62	1	6	4
54	3x27	nk1_on	7.65167	7.135	3	4	4
55	3x28	nk1_on	7.835	10.09	3	6	5
56	3x31	nk1_on	10.7087	5.9125	2	4	4
57	3x32	nk1_on	9.3525	6.42	2	4	6
58	I2.R141	nk1_on	5.35	8.53	3	4	5
59	5x58	nk1_on	6.34583	8.302	3	5	9
60	6x36	nk1_on	5.58917	5.0775	3	4	8
61	6x37	nk1_on	3.23667	8.7525	3	4	8
62	6x61	nk1_on	3.18	3.51	2	4	4
63	E3.L277	nk1_on	1.48417	3.35	3	4	5
64	7x34	nk1_on	5.90083	11.15	3	4	5
65	7x38	nk1_on	7.03375	6.8925	2	4	5
66	7x42	nk1_on	5.86	5.8375	2	4	7

Orange: nodes, hubs and links specific of nk1_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of nk1_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	nk1_off Recurrence	nk1_on Recurrence	nk1_off Hub1?	nk1_on Hub1?	nk1_off Hub2?	nk1_on Hub2?	ConSurf1	ConSurf2
1	E2x52	Lig	nk1_off	31.2062	0	Yes	No	Yes	Yes	4	0
2	5x461	Lig	nk1_off	11.1208	0	Yes	No	Yes	Yes	6	0
3	1x39	7x38	nk1_off	99.844	0	No	No	No	Yes	7	5
4	7x43	7x48	nk1_off	96.667	4.25167	No	No	No	No	5	5
5	7x39	7x43	nk1_off	96.8805	0	Yes	Yes	No	No	5	5
6	6x40	7x49	nk1_off	56.1077	0	Yes	No	No	No	7	9
7	6x40	7x52	nk1_off	93.958	0	Yes	No	No	No	7	8
8	6x43	7x52	nk1_off	94.4998	0	No	No	No	No	6	8
9	6x43	7x48	nk1_off	94.7625	8.49698	No	No	No	No	6	5
10	1x55	1x60	nk1_off	12.6286	3.52717	Yes	Yes	No	Yes	4	5
11	1x60	I1x50	nk1_off	13.6329	0.203368	No	Yes	Yes	No	5	7
12	8x50	I1x50	nk1_off	18.0002	0	Yes	Yes	Yes	No	9	7
13	6x37	6x40	nk1_off	63.3729	0	No	Yes	Yes	No	8	7
14	3x47	5x58	nk1_off	60.3081	2.21163	No	No	No	Yes	9	9
15	3x47	5x57	nk1_off	57.5607	0	No	No	No	No	9	7
16	3x48	5x57	nk1_off	40.1899	0	No	No	No	No	5	7
17	3x48	3x52	nk1_off	39.3635	4.16269	No	No	No	No	5	5
18	3x52	I2.R141	nk1_off	38.5316	0	No	No	No	Yes	5	5
19	3x49	I2.R141	nk1_off	35.8965	8.99905	Yes	No	No	Yes	9	5
20	2x38	3x49	nk1_off	21.9762	0	No	Yes	Yes	No	6	9
21	2x38	4x42	nk1_off	21.2183	7.35303	No	Yes	Yes	Yes	6	7
22	2x39	3x49	nk1_off	12.3741	0	No	No	Yes	No	8	9
23	2x39	3x46	nk1_off	11.5888	0	No	No	No	No	8	9
24	2x42	3x46	nk1_off	10.6803	0	Yes	Yes	No	No	7	9
25	E1x50	E1x52	nk1_off	15.1188	7.02892	Yes	Yes	Yes	Yes	8	7
26	E1x51	E1x52	nk1_off	10.9101	0	Yes	No	Yes	Yes	2	7
27	2x64	E1x51	nk1_off	11.088	0	No	Yes	Yes	No	4	2
28	E1x49	E1x51	nk1_off	12.8585	3.92755	No	No	Yes	No	4	2
29	3x25	E1x50	nk1_off	11.3945	3.78138	No	No	Yes	Yes	9	8
30	3x29	4x61	nk1_off	25.1724	0	Yes	No	Yes	Yes	5	6
31	3x29	E2x52	nk1_off	23.5771	0	Yes	No	Yes	No	5	4
32	3x37	5x461	nk1_off	11.2631	6.67302	Yes	No	Yes	No	7	6
33	3x51	5x57	nk1_off	21.823	2.20527	Yes	Yes	No	No	8	7
34	3x51	3x55	nk1_off	14.9491	6.42517	Yes	Yes	Yes	Yes	8	7
35	3x54	3x55	nk1_off	13.1513	0	No	No	Yes	Yes	8	7
36	E2.W184	E2x52	nk1_off	10.0618	0.177947	Yes	Yes	Yes	No	5	4
37	5x36	Lig	nk1_off	14.7877	0	Yes	No	Yes	Yes	4	0
38	E2.P185	E2.W184	nk1_off	18.3204	0	Yes	No	Yes	Yes	4	5
39	5x31	E2.H187	nk1_off	11.5313	0	No	No	No	No	1	2
40	3x28	3x29	nk1_off	47.4907	0	No	Yes	Yes	No	5	5
41	4x61	Lig	Shared	32.5033	67.836	Yes	Yes	Yes	Yes	6	0
42	6x55	Lig	Shared	90.3048	19.8729	No	No	Yes	Yes	6	0
43	1x39	7x39	Shared	99.1353	58.4493	No	No	Yes	Yes	7	5
44	7x34	7x38	Shared	99.948	10.2383	No	Yes	No	Yes	5	5
45	6x54	7x34	Shared	100	34.1913	Yes	Yes	No	Yes	4	5
46	6x54	6x55	Shared	95.1018	24.3534	Yes	Yes	No	No	4	6
47	2x50	7x49	Shared	13.3018	45.8278	Yes	Yes	No	No	9	9
48	1x56	8x50	Shared	11.2002	33.81	No	Yes	Yes	Yes	8	9
49	7x53	8x50	Shared	37.3167	46.7429	Yes	No	Yes	Yes	9	9
50	7x49	7x53	Shared	45.6929	49.1897	No	No	Yes	No	9	9
51	5x58	6x37	Shared	62.1771	60.3559	No	Yes	No	Yes	9	8
52	2x42	4x42	Shared	10.9785	26.7048	Yes	Yes	Yes	Yes	7	7
53	2x42	4x46	Shared	15.7372	48.7957	Yes	Yes	No	No	7	8
54	2x45	4x46	Shared	13.7889	52.469	No	No	No	No	9	8
55	3x28	E1x50	Shared	46.8093	11.2488	No	Yes	Yes	Yes	5	8
56	2x64	E1x50	Shared	12.6779	10.7912	No	Yes	Yes	Yes	4	8
57	4x61	E2.W184	Shared	10.2206	24.15	Yes	Yes	Yes	Yes	6	5
58	E2.H187	E2.P185	Shared	13.8217	13.5685	No	No	Yes	No	2	4
59	NT.N23	NT.V26	nk1_on	0	16.2568	No	Yes	No	No	0	0
60	2x67	NT.V26	nk1_on	0	12.7042	No	No	No	No	5	0
61	7x31	NT.Q27	nk1_on	0	48.211	No	No	No	Yes	4	4
62	7x31	NT.F25	nk1_on	0	89.374	No	No	No	Yes	4	0
63	2x66	NT.Q27	nk1_on	0	36.6698	No	Yes	No	Yes	5	4
64	1x35	7x32	nk1_on	0	37.9917	Yes	No	No	No	4	1
65	7x31	7x32	nk1_on	0	39.9682	No	No	No	No	4	1
66	1x35	7x35	nk1_on	1.04258	34.3502	Yes	No	No	No	4	3
67	1x39	2x62	nk1_on	5.11165	32.469	No	No	No	No	7	6
68	2x62	2x66	nk1_on	3.0347	36.4983	No	No	No	Yes	6	5
69	1x39	7x35	nk1_on	0	30.5624	No	No	No	No	7	3
70	1x42	7x39	nk1_on	1.05352	25.3511	No	No	Yes	Yes	7	5
71	2x57	7x42	nk1_on	0	48.1093	Yes	Yes	No	Yes	6	7
72	2x57	Lig	nk1_on	0	87.9695	Yes	Yes	Yes	Yes	6	0
73	Lig	NT.F25	nk1_on	0	100	Yes	Yes	No	Yes	0	0
74	1x45	7x47	nk1_on	6.25274	16.9495	Yes	No	No	No	4	7
75	1x42	7x47	nk1_on	0	21.1567	No	No	No	No	7	7
76	1x46	7x46	nk1_on	2.07695	13.435	No	No	No	No	8	9
77	2x53	7x46	nk1_on	0	74.2231	No	Yes	No	No	7	9
78	2x53	7x42	nk1_on	0	52.3864	No	Yes	No	Yes	7	7
79	1x46	1x50	nk1_on	2.10431	10.6768	No	No	Yes	Yes	8	9
80	1x50	2x50	nk1_on	8.24486	13.435	Yes	Yes	Yes	Yes	9	9
81	2x50	7x46	nk1_on	3.10037	61.3727	Yes	Yes	No	No	9	9
82	1x56	I1x50	nk1_on	0	12.7614	No	Yes	Yes	No	8	7
83	1x57	8x50	nk1_on	7.02441	12.8249	No	No	Yes	Yes	7	9
84	8x49	I1x50	nk1_on	2.27123	11.1408	No	No	Yes	No	6	7
85	2x39	I2.R141	nk1_on	0	11.9288	No	No	No	Yes	8	5
86	2x42	3x49	nk1_on	0	11.9733	Yes	Yes	Yes	No	7	9
87	2x45	4x50	nk1_on	9.87577	57.2799	No	No	Yes	Yes	9	9
88	3x31	4x50	nk1_on	0	87.6772	No	Yes	Yes	Yes	4	9
89	3x31	3x32	nk1_on	0	91.2933	No	Yes	No	Yes	4	6
90	2x57	3x32	nk1_on	5.63978	52.1322	Yes	Yes	No	Yes	6	6
91	3x28	3x32	nk1_on	0	48.5224	No	Yes	No	Yes	5	6
92	3x28	Lig	nk1_on	0	56.9177	No	Yes	Yes	Yes	5	0
93	2x45	3x42	nk1_on	1.98391	13.6193	No	No	No	No	9	8
94	2x48	4x50	nk1_on	3.96508	14.5345	No	No	Yes	Yes	6	9
95	3x36	6x48	nk1_on	0.385836	28.0775	Yes	No	Yes	Yes	7	8
96	6x48	6x51	nk1_on	3.67229	72.4055	Yes	Yes	Yes	Yes	8	7
97	6x51	Lig	nk1_on	0.837347	76.136	Yes	Yes	Yes	Yes	7	0
98	7x34	Lig	nk1_on	0	20.9914	No	Yes	Yes	Yes	5	0
99	3x26	4x65	nk1_on	0	12.3228	No	No	No	No	6	5
100	3x29	4x65	nk1_on	0.112194	17.1656	Yes	No	No	No	5	5
101	3x29	Lig	nk1_on	0	17.1338	Yes	No	Yes	Yes	5	0
102	3x33	Lig	nk1_on	4.95841	11.7255	Yes	Yes	Yes	Yes	5	0
103	4x50	4x54	nk1_on	0	10.8929	Yes	Yes	No	No	9	4
104	6x51	6x52	nk1_on	0	26.1837	Yes	Yes	Yes	Yes	7	7
105	6x44	6x48	nk1_on	7.55254	82.7455	No	No	Yes	Yes	9	8
106	3x44	5x50	nk1_on	0	77.9282	No	No	No	No	7	9
107	5x50	6x44	nk1_on	0	81.3346	No	No	No	No	9	9
108	3x44	5x54	nk1_on	1.05352	74.4709	No	No	No	No	7	8
109	5x54	5x58	nk1_on	0	70.9628	No	No	No	Yes	8	9
110	3x55	3x56	nk1_on	0.161449	12.7105	Yes	Yes	Yes	Yes	7	6
111	3x55	5x61	nk1_on	0	27.5755	Yes	Yes	No	No	7	8
112	5x61	6x37	nk1_on	0	45.5863	No	No	No	Yes	8	8
113	3x54	5x61	nk1_on	3.14416	17.3626	No	No	No	No	8	8
114	3x54	5x65	nk1_on	9.15609	15.2272	No	No	No	No	8	8
115	4x61	5x39	nk1_on	2.54488	43.3174	Yes	Yes	Yes	Yes	6	6
116	4x59	4x60	nk1_on	1.55976	28.5732	No	No	No	No	4	8
117	4x60	5x39	nk1_on	3.01828	30.6768	No	No	Yes	Yes	8	6
118	4x59	4x63	nk1_on	0.0738835	26.4315	No	No	No	No	4	4
119	4x63	4x64	nk1_on	2.36975	24.2771	No	No	No	No	4	5
120	4x64	E2.P185	nk1_on	0.0629378	17.7312	No	No	Yes	No	5	4
121	5x39	5x40	nk1_on	0	10.9056	Yes	Yes	Yes	No	6	5
122	5x34	E2.H187	nk1_on	0	11.3378	No	No	No	No	1	2
123	5x36	E2.W184	nk1_on	9.79094	12.3419	Yes	No	Yes	Yes	4	5
124	5x47	6x52	nk1_on	6.57837	12.7677	Yes	Yes	Yes	Yes	8	7
125	5x65	6x34	nk1_on	0	10.931	No	No	No	No	8	6
126	6x36	6x37	nk1_on	0	12.6343	No	Yes	No	Yes	8	8
127	6x43	6x47	nk1_on	0	16.9495	No	No	No	No	6	8
128	6x47	7x40	nk1_on	1.10278	21.1567	No	No	No	No	8	7
129	7x39	7x40	nk1_on	0	25.3511	Yes	Yes	No	No	5	7
130	6x54	7x30	nk1_on	9.04389	40.0953	Yes	Yes	No	No	4	4
131	6x61	E3.L277	nk1_on	0	12.1957	No	Yes	No	Yes	4	5
132	7x29	E3.L277	nk1_on	0	24.3216	No	No	No	Yes	3	5
133	7x29	7x33	nk1_on	0	32.3292	No	No	No	No	3	5
134	7x30	7x33	nk1_on	0	36.3139	No	No	No	No	4	5
135	5x37	6x59	nk1_on	1.04805	19.428	No	No	No	No	3	5
136	5x40	6x59	nk1_on	4.09643	16.8796	Yes	No	No	No	5	5
137	5x40	E2.W184	nk1_on	0	10.054	Yes	No	Yes	Yes	5	5
138	5x37	5x41	nk1_on	0	12.9711	No	No	No	No	3	5
139	2x68	Lig	nk1_on	0	14.1913	No	Yes	Yes	Yes	4	0
140	2x68	NT.N23	nk1_on	0	10.3654	No	Yes	No	Yes	4	0
141	2x46	3x42	nk1_on	0	11.7382	No	No	No	No	9	8
142	2x53	3x36	nk1_on	2.25482	27.3848	No	Yes	Yes	No	7	7

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
3x32	Lig	nk1_off	10.97	0	0	1	1	0
3x33	Lig	Shared	7.3725	14.97	1	1	1	0
3x36	Lig	nk1_off	3.3225	0	1	0	1	0
4x61	Lig	Shared	16.56	9.52	1	1	1	0
E2x52	Lig	nk1_off	3.995	0	1	1	1	0
5x40	Lig	nk1_off	16.3425	0	1	1	1	0
5x43	Lig	nk1_off	3.8775	0	1	0	1	0
5x461	Lig	nk1_off	4.99	0	1	0	1	0
6x48	Lig	nk1_off	5.7075	0	1	1	1	0
6x51	Lig	Shared	18.08	7.46	1	1	1	0
6x52	Lig	nk1_off	5.6375	0	1	0	1	0
6x55	Lig	Shared	17.67	13.95	1	1	1	0
7x42	Lig	nk1_off	3.815	0	0	1	1	0
2x53	2x57	nk1_off	3.8575	0	0	0	2	1
2x53	3x36	Shared	3.2775	4.56	0	0	2	1
2x57	2x61	Shared	3.405	5.45	4	1	1	1
2x57	3x27	nk1_off	6.3425	0	4	1	1	2
2x57	3x31	nk1_off	6.9475	0	4	1	1	2
2x57	3x32	Shared	7.735	4.89	4	1	1	1
2x58	7x42	Shared	7.905	9.03	0	0	2	1
2x61	3x28	Shared	8.925	12.75	0	1	1	1
2x64	E1x50	Shared	10.61	11.58	0	1	1	2
3x28	E1x50	Shared	8.2025	4.23	0	1	1	2
3x27	3x31	Shared	14.47	7.5	4	1	2	2
3x28	3x29	nk1_off	6.3775	0	0	1	1	1
3x29	4x61	nk1_off	5.28	0	1	1	1	1
3x29	4x65	Shared	6.3325	5.96	1	1	1	2
3x29	E2x52	nk1_off	9.205	0	1	1	1	1
3x33	4x57	Shared	3.25	3.25	1	1	1	2
3x33	4x61	Shared	5.1475	5.49	1	1	1	1
3x33	5x43	nk1_off	4.61	0	1	1	1	1
3x36	5x461	nk1_off	4.8475	0	1	0	1	1
3x36	6x48	Shared	6.5	4.9	1	0	1	1
3x37	3x41	nk1_off	18.31	0	0	0	2	2
3x37	5x461	Shared	3.77	11.3	0	0	2	1
3x40	3x41	nk1_off	3.63	0	7	1	2	2
3x40	6x44	Shared	11.3025	7.54	7	1	2	2
4x56	5x43	Shared	3.725	4.47	0	0	2	1
4x61	E2x52	Shared	6.5175	6.86	1	1	1	1
4x61	E2.W184	Shared	3.56	6.57	1	1	1	2
4x61	5x39	Shared	9.58	15.78	1	1	1	2
4x65	E2x52	nk1_off	4.2575	0	1	0	2	1
E2.E172	E2.M174	Shared	3.72	6.77	0	1	1	1
E2.E172	E2.E183	nk1_off	6.98	0	0	1	1	2
E2.E183	E2x51	nk1_off	5.7425	0	0	0	2	1
E2.W184	E2x52	Shared	6.7525	17.62	1	1	2	1
5x36	E2.W184	Shared	16.085	18.54	0	0	1	2
5x39	E2.W184	Shared	6.27	13.5	1	1	2	2
5x33	5x36	Shared	7.0875	12.15	0	0	2	1
5x39	5x43	Shared	6.6225	6.31	1	1	2	1
5x40	5x44	nk1_off	3.425	0	1	1	1	2
5x40	6x56	nk1_off	5.145	0	1	1	1	2
5x40	6x59	Shared	7.6225	15.24	1	1	1	2
5x44	6x52	Shared	9.24	12.32	1	0	2	1
5x44	6x56	Shared	3.6825	5.9	1	0	2	2
5x461	6x52	Shared	4.3075	5.3	1	0	1	1
5x47	6x52	Shared	7.6225	9.8	0	0	2	1
6x44	6x48	Shared	9.77	8.02	0	1	2	1
6x48	6x51	Shared	8.7675	11.02	1	1	1	1
6x48	7x41	Shared	5.835	7.78	1	1	1	2
6x48	7x45	Shared	7.1025	4.94	1	1	1	2
6x51	6x55	Shared	8.8425	11.79	1	1	1	1
6x51	7x41	Shared	4.5075	4.16	1	1	1	2
6x54	6x55	Shared	8.8425	10.72	0	0	2	1
6x54	7x34	Shared	8.2525	9.28	0	0	2	1
7x34	7x38	Shared	7.7825	11.97	0	1	1	2
E2.M174	E2.P175	Shared	3.3525	6.71	0	1	1	2
2x64	E1x51	nk1_off	3.475	0	0	1	1	2
5x36	Lig	nk1_off	4.31	0	0	0	1	0
5x36	E2.E183	nk1_off	2.22	0	0	0	1	2
E2.E172	E2.V179	nk1_off	2.14	0	0	1	1	1
2x68	E2.R177	Shared	2.11	13.26	0	1	1	2
2x65	7x34	nk1_off	1.6675	0	0	0	2	1
E3.L277	E3.L279	nk1_off	1.385	0	0	7	2	1
NT.F25	NT.N23	nk1_on	0	8.46	0	1	1	2
2x68	NT.N23	nk1_on	0	4.09	0	1	1	2
E2.R177	NT.N23	nk1_on	0	14.46	0	1	2	2
NT.F25	NT.Q24	nk1_on	0	14.05	0	1	1	2
2x68	NT.F25	nk1_on	0	8.46	0	1	1	1
7x31	NT.F25	nk1_on	0	9.37	0	0	2	1
Lig	NT.F25	nk1_on	0	16.08	1	1	0	1
2x53	7x42	nk1_on	0	4.33	0	0	2	1
2x57	3x28	nk1_on	0	8.93	4	1	1	1
2x57	7x38	nk1_on	0	4.21	4	1	1	2
2x57	7x42	nk1_on	0	4.21	4	1	1	1
2x57	Lig	nk1_on	0	10.2	4	1	1	0
2x60	3x28	nk1_on	0	12.45	0	1	2	1
2x61	7x34	nk1_on	0	8.14	0	1	1	1
2x61	7x38	nk1_on	0	5.61	0	1	1	2
2x61	Lig	nk1_on	0	10.27	0	1	1	0
2x64	2x68	nk1_on	0	6.98	0	1	1	1
2x64	E2.V179	nk1_on	0	6.31	0	1	1	1
2x64	Lig	nk1_on	0	9.99	0	1	1	0
2x68	E2.V179	nk1_on	0	4.43	0	1	1	1
2x68	Lig	nk1_on	0	14.5	0	1	1	0
3x27	3x32	nk1_on	0	4.33	4	1	2	1
3x28	3x32	nk1_on	0	10.68	0	1	1	1
3x28	Lig	nk1_on	0	11.5	0	1	1	0
3x29	3x33	nk1_on	0	4.25	1	1	1	1
3x29	Lig	nk1_on	0	8.24	1	1	1	0
3x31	3x32	nk1_on	0	5.78	4	1	2	1
3x33	3x37	nk1_on	0	5.02	1	1	1	2
3x37	4x56	nk1_on	0	12.18	0	0	2	2
3x40	6x48	nk1_on	0	9.4	7	1	2	1
E2.E172	Lig	nk1_on	0	6.29	0	1	1	0
E2.M174	Lig	nk1_on	0	6.7	0	1	1	0
E2.V179	Lig	nk1_on	0	10.49	0	1	1	0
E2x51	Lig	nk1_on	0	8.71	0	0	1	0
5x40	E2.W184	nk1_on	0	4.23	1	1	1	2
5x36	6x59	nk1_on	0	6.73	0	0	1	2
5x39	5x40	nk1_on	0	7.62	1	1	2	1
6x51	6x52	nk1_on	0	5.66	1	1	1	1
E3.L279	Lig	nk1_on	0	8.06	0	0	1	0
7x34	Lig	nk1_on	0	15.21	0	1	1	0
7x38	7x42	nk1_on	0	5.78	0	1	2	1
3x41	5x461	nk1_on	0	3.63	7	0	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	nk1_off	6HLP-NK₁-Netupitant 6HLO-NK₁-Aprepitant 6HLL-NK₁-CP99994 6E59-NK₁-L-760735
	nk1_on	7P00-NK₁-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2

Network Difference
Value	nk1_off	nk1_on
I_min	3.24	4
Number of Linked Nodes	283	267
Number of Specific Nodes	23 (8.13%)	7 (2.62%)
Number of Shared Nodes	260 (91.87%)	260 (97.38%)
Number of Links	322	318
Number of Specific Links	139 (43.17%)	135 (42.45%)
Number of Shared Links	183 (56.83%)	183 (57.55%)
Number of Hubs	42	48
Number of Specific Hubs	18 (42.86%)	24 (50.00%)
Number of Shared Hubs	24 (57.14%)	24 (50.00%)
Average % Shared Neighbours (Jaccard)	44.89
Average % Shared Neighbours (Otsuka)	53.80
Average % Shared Neighbours (Overlap Coefficient)	62.10
Average % Shared Cliques (k3-6)	54.17
Graphlets Similarity	0.647183

Paths Difference
Value	nk1_off	nk1_on
Number Of Nodes in MetaPath	55	98
Specific Nodes in MetaPath	21 (38.18%)	64 (65.31%)
Shared Nodes in MetaPath	260 (91.87%)	260 (91.87%)
Number Of Links MetaPath	58	102
Specific Links in MetaPath	40 (68.97%)	84 (82.35%)
Shared Links in MetaPath	183 (56.83%)	183 (56.83%)
Number of Shortest Paths	66208	56792
Length Of Smallest Path	3	3
Average Path Length	17.2079	12.6728
Length of Longest Path	37	27
Minimum Path Strength	0.37375	1.21
Average Path Strength	6.61539	7.81118
Maximum Path Strength	17.2113	20.675
Minimum Path Correlation	0.7	0.7
Average Path Correlation	0.913157	0.919552
Maximum Path Correlation	0.99	0.99
Minimum % Of Corr. Nodes	3.22581	4.54545
Average % Of Corr. Nodes	34.0261	50.3021
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	37.1365	49.7804
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

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