psnGPCR

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Orange: nodes, hubs and links specific of nop_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of nop_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	nop_off Int. Strength	nop_on Int. Strength	nop_off Hub1?	nop_on Hub1?	nop_off Hub2?	nop_on Hub2?	ConSurf1	ConSurf2
1	3x32	Lig	nop_off	22.66	0	No	No	Yes	Yes	6	0
2	5x461	Lig	nop_off	3.67333	0	Yes	No	Yes	Yes	6	0
3	7x42	Lig	nop_off	4.76667	0	Yes	Yes	Yes	Yes	6	0
4	1x31	NT.P47	nop_off	7.11667	0	No	No	No	No	4	6
5	1x31	7x36	nop_off	3.65333	0	No	No	No	No	4	5
6	1x39	2x57	nop_off	4.3	0	Yes	Yes	Yes	No	7	7
7	1x39	7x42	nop_off	4.96	0	Yes	Yes	Yes	Yes	7	6
8	1x42	7x43	nop_off	3.21	0	Yes	No	No	No	7	5
9	1x47	2x55	nop_off	3.22667	0	Yes	No	No	No	6	4
10	1x49	7x50	nop_off	4.06	0	No	No	No	No	8	9
11	1x50	2x47	nop_off	4.69	0	No	No	No	No	9	9
12	1x54	2x47	nop_off	3.22	0	No	No	No	No	7	9
13	1x55	1x60	nop_off	5.44667	0	No	No	No	No	4	5
14	1x56	8x53	nop_off	5.69	0	No	No	No	No	7	5
15	1x57	2x40	nop_off	5.66667	0	No	Yes	Yes	No	7	8
16	1x60	I1x48	nop_off	5.93333	0	No	No	No	No	5	5
17	8x49	I1x50	nop_off	5.61	0	No	No	No	No	6	7
18	2x38	3x49	nop_off	4.63	0	No	No	No	No	6	8
19	2x39	3x50	nop_off	3.88	0	No	No	Yes	No	8	9
20	2x39	6x33	nop_off	5.06667	0	No	No	No	No	8	7
21	2x40	8x50	nop_off	7.25	0	Yes	No	Yes	No	8	8
22	2x41	4x42	nop_off	3.79	0	Yes	No	No	No	6	7
23	2x41	4x43	nop_off	3.2	0	Yes	No	No	No	6	3
24	2x42	3x45	nop_off	4.89	0	Yes	Yes	No	No	7	7
25	2x43	7x53	nop_off	17.7267	0	No	No	No	Yes	8	9
26	2x43	8x50	nop_off	3.35	0	No	No	Yes	No	8	8
27	2x45	4x49	nop_off	4.25	0	Yes	No	Yes	No	9	6
28	2x46	3x42	nop_off	7.37	0	No	No	No	No	9	7
29	2x50	7x46	nop_off	4.90667	0	No	Yes	No	No	9	8
30	2x52	3x31	nop_off	9.04333	0	No	No	No	No	7	4
31	2x53	3x35	nop_off	12.3167	0	No	No	No	No	7	8
32	2x53	7x46	nop_off	3.23	0	No	No	No	No	7	8
33	2x54	7x46	nop_off	4	0	No	No	No	No	5	8
34	2x56	3x28	nop_off	6.87333	0	No	No	No	No	6	5
35	2x56	3x31	nop_off	4.56	0	No	No	No	No	6	4
36	2x59	3x24	nop_off	3.65	0	No	No	No	No	6	6
37	2x60	7x42	nop_off	10.8967	0	No	No	Yes	Yes	5	6
38	E1x49	E2.I198	nop_off	3.35	0	No	No	No	No	4	4
39	3x28	E1x50	nop_off	3.27	0	No	No	Yes	Yes	5	8
40	3x34	4x57	nop_off	5.79	0	Yes	Yes	No	No	5	7
41	3x35	3x39	nop_off	3.97333	0	No	No	No	No	8	9
42	3x37	3x41	nop_off	3.93333	0	No	No	Yes	No	6	5
43	3x38	4x49	nop_off	3.54667	0	No	No	Yes	No	6	6
44	3x39	6x44	nop_off	6.61	0	No	No	Yes	No	9	9
45	3x40	3x41	nop_off	3.89	0	No	No	Yes	No	7	5
46	3x41	4x52	nop_off	4.05667	0	Yes	No	No	No	5	4
47	3x43	6x41	nop_off	4.96667	0	No	No	No	No	8	7
48	3x43	6x44	nop_off	6.09	0	No	No	Yes	No	8	9
49	3x44	5x54	nop_off	4.56	0	No	No	No	No	8	8
50	3x46	6x37	nop_off	4.05333	0	No	No	No	No	9	7
51	3x49	3x50	nop_off	3.96667	0	No	No	Yes	No	8	9
52	3x50	3x53	nop_off	4.15	0	Yes	No	No	No	9	8
53	3x50	6x33	nop_off	9.60333	0	Yes	No	No	No	9	7
54	3x50	6x34	nop_off	7.33333	0	Yes	No	No	No	9	6
55	3x50	6x37	nop_off	6.54	0	Yes	No	No	No	9	7
56	3x51	5x61	nop_off	6.78333	0	No	No	No	No	8	8
57	E2.Q192	E2.S190	nop_off	8.18	0	No	No	No	No	2	3
58	E2.E203	E2.Q192	nop_off	5.09667	0	No	No	No	No	1	2
59	E2.D195	E2.E196	nop_off	6.49667	0	No	No	No	No	1	3
60	E2.E196	E2.E197	nop_off	3.38333	0	No	No	No	No	3	2
61	5x39	E2.P205	nop_off	4.81333	0	No	No	No	No	6	4
62	5x34	5x38	nop_off	7.15	0	No	No	No	No	3	3
63	5x35	5x38	nop_off	4.08333	0	Yes	No	No	No	4	3
64	5x35	5x39	nop_off	4.01	0	Yes	No	No	No	4	6
65	5x37	6x60	nop_off	3.28	0	No	No	No	No	3	4
66	5x42	5x46	nop_off	4.19	0	No	No	No	No	3	4
67	5x45	5x46	nop_off	3.65	0	No	No	No	No	4	4
68	5x54	6x41	nop_off	5.12	0	No	No	No	No	8	7
69	5x58	6x34	nop_off	3.74667	0	Yes	Yes	No	No	9	6
70	5x58	6x38	nop_off	15.63	0	Yes	Yes	No	No	9	4
71	5x68	I3.L248	nop_off	9.43667	0	No	No	No	No	6	3
72	I3.L247	I3.R246	nop_off	4.85667	0	No	No	No	No	5	4
73	6x24	I3.L247	nop_off	8.90667	0	No	No	No	No	4	5
74	6x27	I3.G250	nop_off	3.35333	0	No	No	No	No	3	4
75	6x28	6x32	nop_off	7.46	0	No	No	No	No	4	8
76	6x36	8x47	nop_off	4.07	0	No	No	No	No	8	8
77	6x39	7x56	nop_off	4.96667	0	No	No	No	No	6	6
78	6x40	7x49	nop_off	3.45	0	No	No	No	No	8	9
79	6x43	7x52	nop_off	6.45667	0	No	No	No	No	6	8
80	6x48	6x51	nop_off	7.36	0	Yes	Yes	No	No	8	6
81	6x48	7x41	nop_off	10.79	0	Yes	Yes	No	No	8	7
82	6x48	7x42	nop_off	3.53667	0	Yes	Yes	Yes	Yes	8	6
83	6x54	7x37	nop_off	6.05333	0	No	No	No	No	5	6
84	6x55	6x58	nop_off	3.34667	0	No	No	No	No	5	4
85	6x58	E3.Q291	nop_off	4.69333	0	No	No	No	No	4	6
86	E3.P292	E3.Q291	nop_off	7.37333	0	No	No	No	No	4	6
87	7x43	7x48	nop_off	3.97333	0	No	No	No	No	5	6
88	7x49	7x53	nop_off	6.97667	0	No	No	No	Yes	9	9
89	7x53	8x50	nop_off	5.50333	0	No	Yes	Yes	No	9	8
90	8x47	8x50	nop_off	15.1267	0	No	No	Yes	No	8	8
91	3x50	I2x57	nop_off	4.26333	0	Yes	No	No	No	9	0
92	6x32	6x35	nop_off	4.62	0	No	No	No	No	8	6
93	7x28	NT.P47	nop_off	3.66667	0	No	No	No	No	3	6
94	1x60	8x56	nop_off	3.93	0	No	No	No	No	5	0
95	6x25	6x26	nop_off	5.85	0	No	No	No	No	3	3
96	3x44	5x53	nop_off	3.17	0	No	No	No	No	8	7
97	6x45	6x49	nop_off	3.17	0	No	No	Yes	No	6	6
98	6x58	7x34	nop_off	3.10333	0	No	No	No	No	4	4
99	2x41	4x39	nop_off	3.1	0	Yes	No	No	No	6	3
100	5x43	5x461	nop_off	3.1	0	No	No	Yes	No	4	6
101	E2.E194	E2x51	nop_off	3.09333	0	Yes	No	No	No	1	3
102	1x53	8x50	nop_off	3.05667	0	No	Yes	Yes	No	9	8
103	2x48	4x50	nop_off	3.04	0	No	No	Yes	No	6	9
104	1x42	2x57	nop_off	2.98	0	Yes	No	Yes	No	7	7
105	E2.E194	E2.E199	nop_off	2.96	0	Yes	No	No	No	1	2
106	3x47	5x57	nop_off	2.86667	0	No	No	No	No	9	7
107	3x48	5x57	nop_off	2.85	0	No	No	No	No	7	7
108	6x57	E3.V290	nop_off	2.82667	0	No	No	No	No	4	2
109	1x32	2x65	nop_off	2.82	0	No	No	No	No	4	4
110	8x53	8x56	nop_off	2.69333	0	No	No	No	No	5	0
111	6x47	7x40	nop_off	2.64667	0	No	No	No	No	8	7
112	7x31	7x35	nop_off	2.62	0	No	No	No	No	3	4
113	3x22	E2.A191	nop_off	2.60667	0	No	No	No	No	2	4
114	7x31	NT.L46	nop_off	2.48333	0	No	No	No	No	3	0
115	5x65	6x31	nop_off	2.43	0	No	No	No	No	8	4
116	3x50	6x30	nop_off	2.42667	0	Yes	No	No	No	9	6
117	I2x50	I3.S249	nop_off	2.37667	0	No	No	No	No	7	4
118	2x49	3x38	nop_off	2.24	0	No	No	No	No	8	6
119	3x30	3x34	nop_off	2.22333	0	No	No	Yes	Yes	5	5
120	5x46	5x49	nop_off	2.18333	0	No	No	No	No	4	5
121	4x38	4x40	nop_off	2.13333	0	No	No	No	No	7	4
122	4x57	4x59	nop_off	2.03	0	No	No	No	No	7	7
123	6x39	7x52	nop_off	1.98667	0	No	No	No	No	6	8
124	6x40	7x52	nop_off	1.98667	0	No	No	No	No	8	8
125	I1x49	I1x51	nop_off	1.91333	0	No	No	No	No	6	7
126	1x29	1x32	nop_off	1.88	0	No	No	No	No	5	4
127	4x64	E2.S190	nop_off	1.86	0	No	No	No	No	5	3
128	3x52	3x56	nop_off	1.84333	0	No	No	No	No	5	6
129	1x44	1x45	nop_off	1.84	0	No	No	No	No	5	5
130	6x45	6x46	nop_off	1.84	0	No	No	No	No	6	5
131	6x27	I3.L247	nop_off	1.80667	0	No	No	No	No	3	5
132	1x34	7x36	nop_off	1.72667	0	No	No	No	No	4	5
133	1x45	1x48	nop_off	1.71	0	No	No	No	No	5	4
134	1x49	1x52	nop_off	1.71	0	No	No	No	No	8	6
135	6x54	7x33	nop_off	1.67667	0	No	No	No	No	5	4
136	1x52	8x54	nop_off	1.62667	0	No	No	No	No	6	5
137	5x40	6x56	nop_off	1.58	0	No	No	No	No	4	5
138	1x29	1x30	nop_off	1.14	0	No	No	No	No	5	6
139	5x68	I3.S249	nop_off	1.07667	0	No	No	No	No	6	4
140	3x23	3x24	nop_off	1.05333	0	No	No	No	No	1	6
141	5x66	5x67	nop_off	1	0	No	No	No	No	5	4
142	6x27	I3.S249	nop_off	0.98	0	No	No	No	No	3	4
143	7x55	7x56	nop_off	0.813333	0	No	No	No	No	6	6
144	2x66	2x67	nop_off	0.57	0	No	No	No	No	5	4
145	1x47	1x51	nop_off	0.53	0	Yes	No	No	No	6	4
146	4x41	I2x56	nop_off	0.506667	0	No	No	No	No	4	0
147	7x54	7x55	nop_off	0.463333	0	No	No	No	No	7	6
148	8x48	8x49	nop_off	0.436667	0	No	No	No	No	5	6
149	6x24	6x25	nop_off	0.386667	0	No	No	No	No	4	3
150	2x60	Lig	Shared	12.7367	9.37	No	No	Yes	Yes	5	0
151	2x63	Lig	Shared	7.40333	5.96	No	No	Yes	Yes	4	0
152	3x29	Lig	Shared	8.55333	5.02	No	Yes	Yes	Yes	4	0
153	3x33	Lig	Shared	13.7167	8.25	No	No	Yes	Yes	4	0
154	3x36	Lig	Shared	11.1367	9.95	No	No	Yes	Yes	7	0
155	6x52	Lig	Shared	10.87	4.68	Yes	Yes	Yes	Yes	7	0
156	6x55	Lig	Shared	6.15667	9.71	No	No	Yes	Yes	5	0
157	1x35	1x39	Shared	5.24	6.04	No	Yes	Yes	Yes	5	7
158	1x35	7x36	Shared	9.21	5.02	No	Yes	No	No	5	5
159	1x36	2x61	Shared	3.68	3.68	Yes	Yes	No	No	4	6
160	1x36	2x65	Shared	7.45	11.92	Yes	Yes	No	No	4	4
161	1x37	1x40	Shared	3.42	3.42	No	No	No	No	5	4
162	1x39	2x64	Shared	4.03333	4.84	Yes	Yes	No	Yes	7	4
163	1x42	7x47	Shared	7.4	3.42	Yes	No	No	No	7	7
164	1x43	2x58	Shared	3.77	3.77	No	No	No	No	6	8
165	1x46	2x54	Shared	3.99	1.71	No	No	No	No	7	5
166	1x47	2x54	Shared	6	5.54	Yes	No	No	No	6	5
167	1x50	2x50	Shared	9.42667	6.73	No	No	No	Yes	9	9
168	1x50	7x50	Shared	9.23	6.52	No	No	No	No	9	9
169	1x54	2x44	Shared	11.6133	7.46	No	No	No	No	7	5
170	1x55	1x59	Shared	4.80333	6.17	No	No	No	No	4	5
171	1x57	8x50	Shared	5.02	2.51	No	Yes	Yes	No	7	8
172	1x58	1x59	Shared	6.47667	2.43	No	No	No	No	3	5
173	I1x48	I1x50	Shared	7.02667	4.52	No	No	No	No	5	7
174	2x40	I1x50	Shared	6.07667	5.61	Yes	No	No	No	8	7
175	2x37	2x40	Shared	5.85	8.77	No	No	Yes	No	7	8
176	2x41	4x46	Shared	3.30667	2.83	Yes	No	No	No	6	7
177	2x42	3x46	Shared	5.19	5.99	Yes	Yes	No	No	7	9
178	2x42	4x42	Shared	6.67333	5.34	Yes	Yes	No	No	7	7
179	2x42	4x45	Shared	9.67333	2.52	Yes	Yes	No	No	7	5
180	2x42	4x46	Shared	5.03667	6.98	Yes	Yes	No	No	7	7
181	2x45	3x42	Shared	8.77	5.85	Yes	No	No	No	9	7
182	2x45	4x46	Shared	19.9767	8.17	Yes	No	No	No	9	7
183	2x45	4x50	Shared	6.02667	12.43	Yes	No	Yes	No	9	9
184	2x50	7x49	Shared	6.28333	8.08	No	Yes	No	No	9	9
185	2x56	2x60	Shared	4.72333	4.25	No	No	No	No	6	5
186	2x57	7x42	Shared	8.59667	8.21	Yes	No	Yes	Yes	7	6
187	2x59	E1x52	Shared	14.2867	12.86	No	No	Yes	Yes	6	6
188	2x62	E1x52	Shared	8.64667	5.19	No	No	Yes	Yes	4	6
189	2x63	E1x50	Shared	8.18667	8.93	No	No	Yes	Yes	4	8
190	2x64	7x35	Shared	3.75667	11.27	No	Yes	No	No	4	4
191	2x66	E1x49	Shared	8.52667	3.65	No	No	No	No	5	4
192	2x66	E1x51	Shared	4.93	3.28	No	No	No	No	5	3
193	E1x49	E1x51	Shared	9.15	8.67	No	No	No	No	4	3
194	E1x50	E1x52	Shared	14.03	22.05	Yes	Yes	Yes	Yes	8	6
195	3x25	E1x50	Shared	4.78667	5.22	No	No	Yes	Yes	9	8
196	E1x50	E2x50	Shared	6.53	14.37	Yes	Yes	No	Yes	8	9
197	E1x51	E1x52	Shared	7.70333	2.89	No	No	Yes	Yes	3	6
198	3x24	E1x52	Shared	4.87	6.09	No	No	Yes	Yes	6	6
199	3x22	3x26	Shared	3.26667	8.39	No	No	No	No	2	6
200	3x22	E2.S190	Shared	3.97333	4.47	No	No	No	No	2	3
201	3x25	E2.A191	Shared	3.61	1.81	No	No	No	No	9	4
202	3x25	E2x50	Shared	7.28	7.28	No	No	No	Yes	9	9
203	3x29	E2x50	Shared	3.27	3.27	No	Yes	No	Yes	4	9
204	3x32	7x42	Shared	5.36667	6.9	No	No	Yes	Yes	6	6
205	3x33	4x60	Shared	10.0933	2.52	No	No	No	No	4	4
206	3x34	4x50	Shared	6.75333	10.61	Yes	Yes	Yes	No	5	9
207	3x34	4x54	Shared	6.78333	7.63	Yes	Yes	No	No	5	4
208	3x36	6x48	Shared	13.5733	6.98	No	No	Yes	Yes	7	8
209	3x37	4x56	Shared	13.5467	5.24	No	No	No	No	6	5
210	3x37	5x461	Shared	8.81	1.32	No	No	Yes	No	6	6
211	3x38	4x50	Shared	6.06333	14.55	No	No	Yes	No	6	9
212	3x40	5x50	Shared	6.99	3.5	No	No	No	No	7	8
213	3x41	4x49	Shared	4.60333	1.26	Yes	No	Yes	No	5	6
214	3x42	4x49	Shared	5.06667	3.04	No	No	Yes	No	7	6
215	3x47	5x54	Shared	10.84	9.29	No	No	No	No	9	8
216	3x47	5x58	Shared	3.39	8.9	No	No	Yes	Yes	9	9
217	3x51	3x55	Shared	10.75	6.72	No	No	No	No	8	7
218	3x51	5x60	Shared	9.38	7.03	No	No	No	No	8	4
219	3x54	5x61	Shared	6.31667	7.29	No	No	No	No	8	8
220	3x54	5x65	Shared	3.80333	2.85	No	No	No	No	8	8
221	3x55	3x56	Shared	6.88	4.42	No	No	No	No	7	6
222	4x38	4x41	Shared	4.50333	9.01	No	No	No	No	7	4
223	4x58	4x59	Shared	4.71	3.53	No	No	No	No	4	7
224	E2.I198	E2.V193	Shared	3.58333	7.68	No	No	No	No	4	2
225	E2.I204	E2.P205	Shared	3.95333	3.39	No	No	No	No	5	4
226	5x35	E2.P205	Shared	10.8067	5.4	Yes	No	No	No	4	4
227	5x31	E2.T206	Shared	4.08333	1.75	No	No	No	No	4	2
228	5x34	5x35	Shared	13.5	2.89	No	No	Yes	No	3	4
229	5x36	5x37	Shared	4.06	4.06	No	No	No	No	3	3
230	5x44	5x48	Shared	9.63	3.77	No	No	No	No	5	4
231	5x44	6x52	Shared	5.07333	7.03	No	No	Yes	Yes	5	7
232	5x44	6x56	Shared	12.5833	10.96	No	No	No	No	5	5
233	5x461	6x52	Shared	4.81333	10.11	Yes	No	Yes	Yes	6	7
234	5x47	6x49	Shared	4.75667	3.89	No	Yes	Yes	No	8	6
235	5x47	6x52	Shared	20.3	5.86	No	Yes	Yes	Yes	8	7
236	5x49	5x50	Shared	4.12	3.53	No	No	No	No	5	8
237	5x58	5x61	Shared	7.18333	4.79	Yes	Yes	No	No	9	8
238	5x58	6x37	Shared	4.20667	6.31	Yes	Yes	No	No	9	7
239	6x44	6x48	Shared	12.36	5.01	Yes	No	Yes	Yes	9	8
240	6x44	7x45	Shared	8.05667	4.83	Yes	No	No	Yes	9	9
241	6x47	7x45	Shared	8.92333	7.87	No	No	No	Yes	8	9
242	6x48	7x45	Shared	5.65	7.91	Yes	Yes	No	Yes	8	9
243	6x49	6x50	Shared	4.08333	3.5	Yes	No	No	No	6	9
244	6x50	7x37	Shared	3.77	3.77	No	No	No	No	9	6
245	7x27	7x29	Shared	4.8	4.8	No	No	No	No	1	3
246	7x38	7x42	Shared	4.16	2.5	No	No	Yes	Yes	5	6
247	8x47	8x49	Shared	4.49	1.35	No	No	No	No	8	6
248	8x54	8x55	Shared	6.77333	4.28	No	No	No	No	5	4
249	3x49	I2x57	Shared	11.5167	5.96	No	No	No	No	8	0
250	3x29	E2x52	Shared	3.07	3.07	No	Yes	No	Yes	4	4
251	4x63	E2x52	Shared	3.04	3.04	No	No	No	Yes	5	4
252	5x56	5x60	Shared	2.98	1.49	No	No	No	No	5	4
253	2x41	I1x51	Shared	2.91	4.36	Yes	No	No	No	6	7
254	7x27	7x30	Shared	2.85	1.71	No	No	No	No	1	3
255	3x21	E1x50	Shared	2.81	2.81	No	No	Yes	Yes	7	8
256	5x31	5x35	Shared	2.7	5.4	No	No	Yes	No	4	4
257	3x34	4x53	Shared	2.67	2.67	Yes	Yes	No	No	5	8
258	E2.D195	E2.E194	Shared	2.6	1.3	No	No	Yes	No	1	1
259	1x36	2x64	Shared	2.56	3.07	Yes	Yes	No	Yes	4	4
260	E2.E194	E2.Q192	Shared	2.54667	5.1	Yes	No	No	No	1	2
261	1x30	1x33	Shared	2.45333	3.68	No	No	No	No	6	5
262	1x47	2x51	Shared	2.45333	2.95	Yes	No	No	No	6	7
263	5x41	5x45	Shared	2.38	2.85	No	No	No	No	5	4
264	1x39	7x39	Shared	2.22333	2.67	Yes	Yes	No	No	7	4
265	1x43	2x57	Shared	2.11333	4.76	No	No	Yes	No	6	7
266	1x45	1x46	Shared	2.11	2.11	No	No	No	No	5	7
267	3x27	3x31	Shared	2.02667	3.04	No	No	No	No	5	4
268	1x38	1x42	Shared	1.98667	2.98	No	No	Yes	No	5	7
269	5x40	6x59	Shared	1.95	1.95	No	No	No	No	4	4
270	6x29	6x33	Shared	1.89	2.83	No	No	No	No	5	7
271	7x30	E3.P292	Shared	1.87	1.87	No	No	No	No	3	4
272	3x55	5x64	Shared	1.85667	2.79	No	No	No	No	7	5
273	5x32	E2.I204	Shared	1.83	5.49	No	No	No	No	5	5
274	3x30	4x61	Shared	1.79	1.79	No	No	No	No	5	4
275	5x36	E2.I204	Shared	1.76	1.76	No	No	No	No	3	5
276	5x47	5x51	Shared	1.74667	3.93	No	Yes	No	Yes	8	6
277	1x48	1x49	Shared	1.71	1.71	No	No	No	No	4	8
278	7x51	7x55	Shared	1.67333	3.77	No	No	No	No	6	6
279	4x39	4x40	Shared	1.63	1.63	No	No	No	No	3	4
280	5x51	5x55	Shared	1.62	1.62	No	Yes	No	No	6	4
281	5x60	5x63	Shared	1.61667	3.64	No	No	No	No	4	3
282	6x49	6x53	Shared	1.59	1.59	Yes	No	No	No	6	6
283	3x56	I2x50	Shared	1.53	1.53	No	No	No	No	6	7
284	6x23	6x26	Shared	1.53	9.18	No	No	No	No	3	3
285	8x48	8x51	Shared	1.35	5.4	No	No	No	No	5	8
286	6x32	8x48	Shared	1.16333	2.33	No	No	No	No	8	5
287	5x38	5x42	Shared	1.14	1.71	No	No	No	No	3	3
288	1x31	7x32	Shared	1.05333	1.58	No	No	No	No	4	1
289	1x36	1x40	Shared	0.993333	1.49	Yes	Yes	No	No	4	4
290	4x58	4x62	Shared	0.513333	3.07	No	No	No	No	4	4
291	5x52	5x56	Shared	0.496667	2.98	No	No	No	No	4	5
292	1x31	1x35	nop_on	0	2.85	No	No	No	Yes	4	5
293	1x35	7x35	nop_on	0	3.76	No	Yes	No	No	5	4
294	1x39	7x38	nop_on	0	2.5	Yes	Yes	No	No	7	5
295	1x43	1x47	nop_on	0	3.17	No	No	Yes	No	6	6
296	1x50	2x51	nop_on	0	4.39	No	No	No	No	9	7
297	1x53	1x57	nop_on	0	3.07	No	Yes	No	Yes	9	7
298	1x53	7x54	nop_on	0	3.39	No	Yes	No	No	9	7
299	1x53	7x55	nop_on	0	2.62	No	Yes	No	No	9	6
300	1x54	2x48	nop_on	0	7.07	No	No	No	No	7	6
301	1x56	1x60	nop_on	0	6.92	No	No	No	No	7	5
302	1x56	8x50	nop_on	0	5.24	No	No	Yes	No	7	8
303	1x57	2x43	nop_on	0	2.94	No	Yes	No	No	7	8
304	1x57	2x44	nop_on	0	3.77	No	Yes	No	No	7	5
305	1x58	2x44	nop_on	0	3.65	No	No	No	No	3	5
306	1x60	8x57	nop_on	0	5.66	No	No	No	No	5	0
307	8x53	I1x48	nop_on	0	5.07	No	No	No	No	5	5
308	8x53	I1x50	nop_on	0	3.24	No	No	No	No	5	7
309	4x39	I1x51	nop_on	0	6.12	No	No	No	No	3	7
310	2x38	2x42	nop_on	0	2.67	No	No	Yes	Yes	6	7
311	2x39	2x43	nop_on	0	3.04	No	No	No	No	8	8
312	2x42	3x49	nop_on	0	6.9	Yes	Yes	No	No	7	8
313	2x46	2x50	nop_on	0	6.79	No	No	No	Yes	9	9
314	2x46	3x43	nop_on	0	5.54	No	No	No	No	9	8
315	2x46	7x49	nop_on	0	2.75	No	No	No	No	9	9
316	2x49	3x39	nop_on	0	3.42	No	No	No	No	8	9
317	2x50	3x39	nop_on	0	2.94	No	Yes	No	No	9	9
318	2x52	3x35	nop_on	0	13.73	No	No	No	No	7	8
319	2x53	7x42	nop_on	0	2.52	No	No	Yes	Yes	7	6
320	2x56	3x32	nop_on	0	11.56	No	No	No	No	6	6
321	2x59	3x28	nop_on	0	2.62	No	No	No	No	6	5
322	E1x49	E2.E197	nop_on	0	3.5	No	No	No	No	4	2
323	3x28	Lig	nop_on	0	2.62	No	No	Yes	Yes	5	0
324	3x31	3x35	nop_on	0	2.83	No	No	No	No	4	8
325	3x33	E2x52	nop_on	0	2.52	No	No	No	Yes	4	4
326	3x34	3x35	nop_on	0	3.49	Yes	Yes	No	No	5	8
327	3x43	7x53	nop_on	0	8.21	No	No	No	Yes	8	9
328	3x44	5x50	nop_on	0	3.5	No	No	No	No	8	8
329	3x50	5x58	nop_on	0	4.12	Yes	No	Yes	Yes	9	9
330	3x50	7x53	nop_on	0	3.09	Yes	No	No	Yes	9	9
331	3x51	5x57	nop_on	0	12.1	No	No	No	No	8	7
332	3x53	I2x57	nop_on	0	5.53	No	No	No	No	8	0
333	I2x55	I2x56	nop_on	0	4.38	No	No	No	No	0	0
334	4x60	E2x52	nop_on	0	3.21	No	No	No	Yes	4	4
335	4x60	5x39	nop_on	0	3.93	No	No	No	No	4	6
336	4x63	5x39	nop_on	0	2.49	No	No	No	No	5	6
337	E2.E203	E2.S190	nop_on	0	8.62	No	No	No	No	1	3
338	E2.Q192	Lig	nop_on	0	2.71	No	No	Yes	Yes	2	0
339	E2.E194	Lig	nop_on	0	10.8	Yes	No	Yes	Yes	1	0
340	E2.E199	E2x51	nop_on	0	2.65	No	No	No	No	2	3
341	E2.E199	Lig	nop_on	0	26.1	No	No	Yes	Yes	2	0
342	E2x50	Lig	nop_on	0	5.59	No	Yes	Yes	Yes	9	0
343	E2x51	Lig	nop_on	0	3.12	No	No	Yes	Yes	3	0
344	5x39	5x43	nop_on	0	6.28	No	No	No	No	6	4
345	5x43	Lig	nop_on	0	2.51	No	No	Yes	Yes	4	0
346	5x45	5x48	nop_on	0	2.85	No	No	No	No	4	4
347	5x47	5x48	nop_on	0	3.77	No	Yes	No	No	8	4
348	5x51	6x44	nop_on	0	2.62	No	Yes	Yes	No	6	9
349	5x51	6x45	nop_on	0	3.21	No	Yes	No	No	6	6
350	5x58	6x41	nop_on	0	2.52	Yes	Yes	No	No	9	7
351	5x62	6x34	nop_on	0	12.16	No	No	No	No	5	6
352	5x64	5x68	nop_on	0	2.62	No	No	No	No	5	6
353	5x65	I3.L248	nop_on	0	5.54	No	No	No	No	8	3
354	5x68	I3.L247	nop_on	0	4.47	No	No	No	No	6	5
355	6x30	I3.L248	nop_on	0	2.77	No	No	No	No	6	3
356	6x26	I3.G250	nop_on	0	3.49	No	No	No	No	3	4
357	6x25	6x28	nop_on	0	11.63	No	No	No	No	3	4
358	6x27	6x30	nop_on	0	2.71	No	No	No	No	3	6
359	6x29	6x32	nop_on	0	3.62	No	No	No	No	5	8
360	6x30	6x34	nop_on	0	2.95	No	No	No	No	6	6
361	6x40	7x53	nop_on	0	2.52	No	No	No	Yes	8	9
362	6x43	7x45	nop_on	0	2.96	No	No	No	Yes	6	9
363	6x51	Lig	nop_on	0	2.62	No	No	Yes	Yes	6	0
364	6x54	6x58	nop_on	0	7.03	No	No	No	No	5	4
365	6x54	7x34	nop_on	0	10.96	No	No	No	No	5	4
366	6x58	E3.P292	nop_on	0	9.47	No	No	No	No	4	4
367	6x58	Lig	nop_on	0	7.19	No	No	Yes	Yes	4	0
368	E3.Q291	Lig	nop_on	0	8.55	No	No	Yes	Yes	6	0
369	E3.P292	Lig	nop_on	0	3.65	No	No	Yes	Yes	4	0
370	E3.S293	Lig	nop_on	0	6.01	No	No	Yes	Yes	1	0
371	7x34	7x38	nop_on	0	2.95	No	No	No	No	4	5
372	7x45	7x48	nop_on	0	2.75	No	Yes	No	No	9	6
373	7x45	7x49	nop_on	0	5.45	No	Yes	No	No	9	9
374	7x48	7x51	nop_on	0	2.85	No	No	No	No	6	6
375	7x48	7x52	nop_on	0	6.92	No	No	No	No	6	8
376	7x55	8x50	nop_on	0	3.22	No	No	Yes	No	6	8
377	8x51	8x55	nop_on	0	3.71	No	No	No	No	8	4
378	8x56	8x57	nop_on	0	2.48	No	No	No	No	0	0
379	Lig	Lig	nop_on	0	14.44	Yes	Yes	Yes	Yes	0	0
380	6x48	7x46	nop_on	0	2.47	Yes	Yes	No	No	8	8
381	3x46	7x53	nop_on	0	2.39	No	No	No	Yes	9	9
382	6x27	6x31	nop_on	0	2.38	No	No	No	No	3	4
383	1x46	7x47	nop_on	0	1.96	No	No	No	No	7	7
384	4x56	4x57	nop_on	0	1.84	No	No	No	No	5	7
385	6x51	7x41	nop_on	0	1.84	No	No	No	No	6	7
386	3x29	4x64	nop_on	0	1.76	No	Yes	No	No	4	5
387	3x26	4x64	nop_on	0	1.74	No	No	No	No	6	5
388	5x53	5x57	nop_on	0	1.71	No	No	No	No	7	7
389	1x53	2x47	nop_on	0	1.7	No	Yes	No	No	9	9
390	7x31	Lig	nop_on	0	1.7	No	No	Yes	Yes	3	0
391	4x63	E2.P205	nop_on	0	1.68	No	No	No	No	5	4
392	7x33	7x37	nop_on	0	1.64	No	No	No	No	4	6
393	3x45	4x49	nop_on	0	1.62	No	No	Yes	No	7	6
394	E2.A191	E2.I198	nop_on	0	1.62	No	No	No	No	4	4
395	5x55	6x41	nop_on	0	1.62	No	No	No	No	4	7
396	3x48	3x52	nop_on	0	1.6	No	No	No	No	7	5
397	3x48	5x53	nop_on	0	1.6	No	No	No	No	7	7
398	3x52	I2x56	nop_on	0	1.6	No	No	No	No	5	0
399	5x49	5x53	nop_on	0	1.6	No	No	No	No	5	7
400	6x39	6x43	nop_on	0	1.6	No	No	No	No	6	6
401	1x56	I1x48	nop_on	0	1.59	No	No	No	No	7	5
402	1x32	1x33	nop_on	0	1.52	No	No	No	No	4	5
403	3x36	3x40	nop_on	0	1.51	No	No	No	No	7	7
404	2x67	Lig	nop_on	0	1.5	No	No	Yes	Yes	4	0
405	5x64	5x67	nop_on	0	1.5	No	No	No	No	5	4
406	6x36	6x40	nop_on	0	1.49	No	No	No	No	8	8
407	1x32	2x64	nop_on	0	1.45	No	No	No	Yes	4	4
408	2x39	8x47	nop_on	0	1.45	No	No	No	No	8	8
409	6x23	6x25	nop_on	0	1.44	No	No	No	No	3	3
410	5x65	6x33	nop_on	0	1.43	No	No	No	No	8	7
411	2x52	2x55	nop_on	0	1.38	No	No	No	No	7	4
412	I2x53	I2x57	nop_on	0	1.38	No	No	No	No	0	0
413	6x36	7x56	nop_on	0	1.38	No	No	No	No	8	6
414	6x35	6x39	nop_on	0	1.31	No	No	No	No	6	6
415	5x62	5x66	nop_on	0	1.25	No	No	No	No	5	5

Orange: nodes, hubs and links specific of nop_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of nop_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	nop_off Avg Int. Strength	nop_on Avg Int. Strength	nop_off Num Of Links	nop_on Num Of Links	ConSurf
1	1x42	nop_off	3.89417	3.2	4	2	7
2	1x47	nop_off	3.0525	3.88667	4	3	6
3	2x40	nop_off	6.21083	7.19	4	2	8
4	2x41	nop_off	3.26133	3.595	5	2	6
5	2x45	nop_off	9.75583	8.81667	4	3	9
6	2x57	nop_off	4.4975	6.485	4	2	7
7	3x41	nop_off	4.12083	1.26	4	1	5
8	3x50	nop_off	5.27042	3.605	8	2	9
9	4x49	nop_off	4.36667	1.97333	4	3	6
10	4x50	nop_off	5.47083	12.53	4	3	9
11	E2.E194	nop_off	2.8	5.73333	4	3	1
12	5x35	nop_off	7.02	4.56333	5	3	4
13	5x461	nop_off	5.09917	5.715	4	2	6
14	6x44	nop_off	8.27917	4.15333	4	3	9
15	6x49	nop_off	3.4	2.99333	4	3	6
16	8x50	nop_off	6.55111	3.65667	6	3	8
17	Lig	Shared	10.1673	7.2387	10	23	0
18	1x36	Shared	3.67083	5.04	4	4	4
19	1x39	Shared	4.15133	4.0125	5	4	7
20	2x42	Shared	6.29267	5.06667	5	6	7
21	E1x50	Shared	6.60222	10.676	6	5	8
22	E1x52	Shared	9.90733	9.816	5	5	6
23	3x34	Shared	4.844	6.1	5	4	5
24	5x58	Shared	6.83133	5.328	5	5	9
25	6x48	Shared	8.87833	5.5925	6	4	8
26	6x52	Shared	10.2642	6.92	4	4	7
27	7x42	Shared	6.04048	5.0325	7	4	6
28	1x35	nop_on	7.225	4.4175	2	4	5
29	1x53	nop_on	3.05667	2.695	1	4	9
30	1x57	nop_on	5.34333	3.0725	2	4	7
31	2x50	nop_on	6.87222	6.135	3	4	9
32	2x64	nop_on	3.45	5.1575	3	4	4
33	3x29	nop_on	4.96444	3.28	3	4	4
34	E2x50	nop_on	5.69333	7.6275	3	4	9
35	E2x52	nop_on	3.055	2.96	2	4	4
36	5x47	nop_on	8.93444	4.3625	3	4	8
37	5x51	nop_on	1.68333	2.845	2	4	6
38	7x45	nop_on	7.54333	5.295	3	6	9
39	7x53	nop_on	10.0689	4.0525	3	4	9

Orange: nodes, hubs and links specific of nop_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of nop_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	nop_off Recurrence	nop_on Recurrence	nop_off Hub1?	nop_on Hub1?	nop_off Hub2?	nop_on Hub2?	ConSurf1	ConSurf2
1	1x39	7x42	nop_off	21.0203	0	Yes	Yes	Yes	Yes	7	6
2	2x54	7x46	nop_off	14.0707	0	No	No	No	No	5	8
3	2x53	7x46	nop_off	75.6444	0	No	No	No	No	7	8
4	2x53	3x35	nop_off	76.892	0	No	No	No	No	7	8
5	3x35	3x39	nop_off	78.1325	0	No	No	No	No	8	9
6	3x39	6x44	nop_off	79.3658	0	No	No	Yes	No	9	9
7	6x44	6x48	nop_off	100	6.16402	Yes	No	Yes	Yes	9	8
8	6x48	7x42	nop_off	60.7407	0	Yes	Yes	Yes	Yes	8	6
9	2x50	7x46	nop_off	62.4674	0	No	Yes	No	No	9	8
10	1x60	I1x48	nop_off	11.1	0	No	No	No	No	5	5
11	I1x48	I1x50	nop_off	12.6765	6.35403	No	No	No	No	5	7
12	2x40	I1x50	nop_off	14.06	4.26389	Yes	No	No	No	8	7
13	2x40	8x50	nop_off	16.902	0	Yes	No	Yes	No	8	8
14	7x53	8x50	nop_off	33.6003	0	No	Yes	Yes	No	9	8
15	7x49	7x53	nop_off	36.4709	0	No	No	No	Yes	9	9
16	8x47	8x50	nop_off	12.294	0	No	No	Yes	No	8	8
17	3x43	6x44	nop_off	52.3684	0	No	No	Yes	No	8	9
18	3x43	6x41	nop_off	51.4139	0	No	No	No	No	8	7
19	5x54	6x41	nop_off	50.656	0	No	No	No	No	8	7
20	3x47	5x54	nop_off	48.629	2.14335	No	No	No	No	9	8
21	3x47	5x58	nop_off	47.0096	4.27909	No	No	Yes	Yes	9	9
22	5x58	6x37	nop_off	21.8854	2.07494	Yes	Yes	No	No	9	7
23	3x50	6x37	nop_off	12.1117	0	Yes	No	No	No	9	7
24	2x41	4x46	nop_off	13.1234	8.53538	Yes	No	No	No	6	7
25	2x45	4x49	nop_off	31.1944	0	Yes	No	Yes	No	9	6
26	3x41	4x49	nop_off	45.8299	2.15095	Yes	No	Yes	No	5	6
27	3x37	3x41	nop_off	58.2919	0	No	No	Yes	No	6	5
28	3x37	5x461	nop_off	59.3787	7.63092	No	No	Yes	No	6	6
29	5x461	Lig	nop_off	55.9969	0	Yes	No	Yes	Yes	6	0
30	3x38	4x49	nop_off	12.9768	0	No	No	Yes	No	6	6
31	3x38	4x50	nop_off	11.1036	2.15095	No	No	Yes	No	6	9
32	3x25	E1x50	nop_off	19.9156	0.326822	No	No	Yes	Yes	9	8
33	3x29	E2x50	nop_off	20.3482	1.89253	No	Yes	No	Yes	4	9
34	3x25	E2x50	nop_off	19.1149	7.10648	No	No	No	Yes	9	9
35	3x25	E2.A191	nop_off	36.2921	5.60158	No	No	No	No	9	4
36	3x22	E2.A191	nop_off	33.5431	0	No	No	No	No	2	4
37	3x22	E2.S190	nop_off	28.0235	3.77746	No	No	No	No	2	3
38	3x40	3x41	nop_off	23.4977	0	No	No	Yes	No	7	5
39	3x51	5x61	nop_off	26.5363	0	No	No	No	No	8	8
40	3x55	3x56	nop_off	17.9459	4.30949	No	No	No	No	7	6
41	E2.Q192	E2.S190	nop_off	22.4752	0	No	No	No	No	2	3
42	E2.E194	E2.Q192	nop_off	16.8984	0.00760052	Yes	No	No	No	1	2
43	5x46	5x49	nop_off	19.9585	0	No	No	No	No	4	5
44	5x42	5x46	nop_off	16.3551	0	No	No	No	No	3	4
45	5x38	5x42	nop_off	15.1396	0	No	No	No	No	3	3
46	5x35	5x38	nop_off	12.6515	0	Yes	No	No	No	4	3
47	3x56	I2x50	nop_off	15.4292	2.15855	No	No	No	No	6	7
48	I2x50	I3.S249	nop_off	14.1601	0	No	No	No	No	7	4
49	6x27	I3.S249	nop_off	10.4458	0	No	No	No	No	3	4
50	6x40	7x49	nop_off	12.8088	0	No	No	No	No	8	9
51	6x40	7x52	nop_off	11.2323	0	No	No	No	No	8	8
52	6x55	Lig	nop_off	11.5933	1.93813	No	No	Yes	Yes	5	0
53	6x55	6x58	nop_off	10.3457	0	No	No	No	No	5	4
54	7x42	Lig	nop_off	60.8909	0	Yes	Yes	Yes	Yes	6	0
55	3x46	6x37	nop_off	18.6716	0	No	No	No	No	9	7
56	6x52	Lig	Shared	17.9852	46.5608	Yes	Yes	Yes	Yes	7	0
57	1x39	2x64	Shared	13.1305	20.7114	Yes	Yes	No	Yes	7	4
58	1x50	2x50	Shared	14.178	22.4291	No	No	No	Yes	9	9
59	2x50	7x49	Shared	49.3261	14.6766	No	Yes	No	No	9	9
60	2x45	4x46	Shared	23.2367	30.7745	Yes	No	No	No	9	7
61	2x42	4x46	Shared	16.3658	40.2751	Yes	Yes	No	No	7	7
62	2x42	3x46	Shared	18.811	54.6857	Yes	Yes	No	No	7	9
63	2x45	4x50	Shared	13.6203	20.8938	Yes	No	Yes	No	9	9
64	E1x50	E1x52	Shared	15.9153	24.2228	Yes	Yes	Yes	Yes	8	6
65	2x63	E1x50	Shared	36.9249	14.7602	No	No	Yes	Yes	4	8
66	2x63	Lig	Shared	37.9616	16.3183	No	No	Yes	Yes	4	0
67	3x29	Lig	Shared	23.7014	27.0502	No	Yes	Yes	Yes	4	0
68	3x34	4x50	Shared	19.5581	16.8351	Yes	Yes	Yes	No	5	9
69	3x40	5x50	Shared	22.3251	42.0689	No	No	No	No	7	8
70	5x58	5x61	Shared	31.0228	33.8299	Yes	Yes	No	No	9	8
71	3x51	3x55	Shared	20.4411	14.6158	No	No	No	No	8	7
72	5x49	5x50	Shared	21.1454	38.3294	No	No	No	No	5	8
73	5x47	6x52	Shared	14.9787	38.9526	No	Yes	Yes	Yes	8	7
74	5x47	6x49	Shared	10.9784	10.5951	No	Yes	Yes	No	8	6
75	3x36	6x48	Shared	45.072	97.3854	No	No	Yes	Yes	7	8
76	3x36	Lig	Shared	45.1435	100	No	No	Yes	Yes	7	0
77	1x35	1x39	nop_on	7.28917	10.5951	No	Yes	Yes	Yes	5	7
78	1x36	2x64	nop_on	9.44482	10.8231	Yes	Yes	No	Yes	4	4
79	1x39	7x38	nop_on	0	34.6508	Yes	Yes	No	No	7	5
80	2x57	7x42	nop_on	7.80395	17.5724	Yes	No	Yes	Yes	7	6
81	1x43	2x57	nop_on	2.1485	17.1848	No	No	Yes	No	6	7
82	1x43	1x47	nop_on	0	16.5463	No	No	Yes	No	6	6
83	1x47	2x54	nop_on	6.4598	12.8069	Yes	No	No	No	6	5
84	1x46	2x54	nop_on	6.29536	10.7091	No	No	No	No	7	5
85	1x47	2x51	nop_on	1.62299	17.3976	Yes	No	No	No	6	7
86	1x50	2x51	nop_on	0	19.0697	No	No	No	No	9	7
87	7x34	7x38	nop_on	0	29.3684	No	No	No	No	4	5
88	6x54	7x34	nop_on	0	30.7441	No	No	No	No	5	4
89	6x54	6x58	nop_on	0	32.401	No	No	No	No	5	4
90	6x58	Lig	nop_on	0	32.8418	No	No	Yes	Yes	4	0
91	6x48	7x45	nop_on	3.39613	90.9554	Yes	Yes	No	Yes	8	9
92	7x45	7x48	nop_on	0	74.105	No	Yes	No	No	9	6
93	7x48	7x51	nop_on	0	70.8368	No	No	No	No	6	6
94	7x51	7x55	nop_on	1.62299	69.1799	No	No	No	No	6	6
95	1x53	7x55	nop_on	0	27.4607	No	Yes	No	No	9	6
96	1x53	1x57	nop_on	0	21.8743	No	Yes	No	Yes	9	7
97	7x55	8x50	nop_on	0	40.4956	No	No	Yes	No	6	8
98	1x57	8x50	nop_on	1.58367	22.0415	No	Yes	Yes	No	7	8
99	1x57	2x44	nop_on	0	23.9492	No	Yes	No	No	7	5
100	1x58	2x44	nop_on	0	12.138	No	No	No	No	3	5
101	1x56	8x50	nop_on	0	18.5301	No	No	Yes	No	7	8
102	1x57	2x43	nop_on	0	16.1359	No	Yes	No	No	7	8
103	1x56	I1x48	nop_on	0	10.5571	No	No	No	No	7	5
104	2x46	2x50	nop_on	0	12.7613	No	No	No	Yes	9	9
105	2x46	3x43	nop_on	0	57.4675	No	No	No	No	9	8
106	3x43	7x53	nop_on	0	56.0614	No	No	No	Yes	8	9
107	3x46	7x53	nop_on	0	56.3578	No	No	No	Yes	9	9
108	2x39	2x43	nop_on	0	12.1304	No	No	No	No	8	8
109	7x45	7x49	nop_on	0	61.6554	No	Yes	No	No	9	9
110	3x34	3x35	nop_on	0	10.6331	Yes	Yes	No	No	5	8
111	3x32	7x42	nop_on	0.554106	12.5485	No	No	Yes	Yes	6	6
112	2x56	3x32	nop_on	0	13.8633	No	No	No	No	6	6
113	2x56	2x60	nop_on	4.47574	15.4899	No	No	No	No	6	5
114	3x28	Lig	nop_on	0	15.049	No	No	Yes	Yes	5	0
115	2x59	3x28	nop_on	0	13.3845	No	No	No	No	6	5
116	E2x50	Lig	nop_on	0	22.6343	No	Yes	Yes	Yes	9	0
117	E1x50	E2x50	nop_on	0.207343	15.9611	Yes	Yes	No	Yes	8	9
118	2x59	E1x52	nop_on	1.46212	11.5604	No	No	Yes	Yes	6	6
119	E1x51	E1x52	nop_on	8.79062	20.453	No	No	Yes	Yes	3	6
120	E1x49	E1x51	nop_on	4.40425	10.2379	No	No	No	No	4	3
121	3x29	E2x52	nop_on	2.72048	19.3357	No	Yes	No	Yes	4	4
122	3x33	Lig	nop_on	2.7884	20.7646	No	No	Yes	Yes	4	0
123	3x33	E2x52	nop_on	0	17.5268	No	No	No	Yes	4	4
124	5x461	6x52	nop_on	4.79748	10.1467	Yes	No	Yes	Yes	6	7
125	3x36	3x40	nop_on	0	43.9158	No	No	No	No	7	7
126	5x47	5x51	nop_on	2.78483	38.7322	No	Yes	No	Yes	8	6
127	5x51	5x55	nop_on	1.3942	42.1525	No	Yes	No	No	6	4
128	5x55	6x41	nop_on	0	40.868	No	No	No	No	4	7
129	5x58	6x41	nop_on	0	39.6291	Yes	Yes	No	No	9	7
130	3x50	5x58	nop_on	0	15.011	Yes	No	Yes	Yes	9	9
131	3x50	7x53	nop_on	0	14.8134	Yes	No	No	Yes	9	9
132	5x49	5x53	nop_on	0	36.4369	No	No	No	No	5	7
133	5x53	5x57	nop_on	0	26.7462	No	No	No	No	7	7
134	3x51	5x57	nop_on	0	24.7625	No	No	No	No	8	7
135	3x54	5x61	nop_on	3.74647	31.9146	No	No	No	No	8	8
136	3x54	5x65	nop_on	2.54531	30.1893	No	No	No	No	8	8
137	5x43	Lig	nop_on	0	19.6017	No	No	Yes	Yes	4	0
138	5x39	5x43	nop_on	0	17.998	No	No	No	No	6	4
139	4x63	E2x52	nop_on	1.47642	33.7691	No	No	No	Yes	5	4
140	4x63	5x39	nop_on	0	16.2651	No	No	No	No	5	6
141	4x63	E2.P205	nop_on	0	45.1395	No	No	No	No	5	4
142	E2.I204	E2.P205	nop_on	6.42763	20.3922	No	No	No	No	5	4
143	5x35	E2.P205	nop_on	7.67526	20.3922	Yes	No	No	No	4	4
144	5x31	5x35	nop_on	2.59178	10.2227	No	No	Yes	No	4	4
145	5x36	E2.I204	nop_on	3.87517	10.2227	No	No	No	No	3	5
146	5x65	I3.L248	nop_on	0	14.7298	No	No	No	No	8	3
147	6x30	I3.L248	nop_on	0	12.6701	No	No	No	No	6	3
148	5x65	6x33	nop_on	0	14.2586	No	No	No	No	8	7
149	6x29	6x33	nop_on	2.34154	12.442	No	No	No	No	5	7
150	6x29	6x32	nop_on	0	10.3671	No	No	No	No	5	8
151	2x60	Lig	nop_on	2.23787	16.8883	No	No	Yes	Yes	5	0
152	6x44	7x45	nop_on	1.25121	17.2912	Yes	No	No	Yes	9	9
153	5x51	6x44	nop_on	0	21.9731	No	Yes	Yes	No	6	9
154	2x46	7x49	nop_on	0	46.0439	No	No	No	No	9	9

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
2x60	Lig	Shared	12.7367	9.37	1	1	1	0
2x63	Lig	Shared	7.40333	5.96	0	1	1	0
3x29	Lig	Shared	8.55333	5.02	0	1	1	0
3x32	Lig	nop_off	22.66	0	1	0	1	0
3x33	Lig	Shared	13.7167	8.25	0	1	1	0
3x36	Lig	Shared	11.1367	9.95	0	1	1	0
5x461	Lig	nop_off	3.67333	0	1	0	1	0
6x52	Lig	Shared	10.87	4.68	1	1	1	0
6x55	Lig	Shared	6.15667	9.71	0	0	1	0
7x42	Lig	nop_off	4.76667	0	1	0	1	0
1x39	2x57	nop_off	4.3	0	1	0	2	2
1x39	7x42	nop_off	4.96	0	1	0	2	1
2x56	2x60	Shared	4.72333	4.25	0	0	2	1
2x56	3x28	nop_off	6.87333	0	0	0	2	1
2x57	7x42	Shared	8.59667	8.21	1	0	2	1
2x60	7x42	nop_off	10.8967	0	1	1	1	1
2x63	E1x50	Shared	8.18667	8.93	0	1	1	2
3x25	E1x50	Shared	4.78667	5.22	2	1	2	2
3x28	E1x50	nop_off	3.27	0	0	1	1	2
E1x50	E2x50	Shared	6.53	14.37	2	1	2	1
3x25	E2x50	Shared	7.28	7.28	2	1	2	1
3x29	E2x50	Shared	3.27	3.27	0	1	1	1
3x32	7x42	Shared	5.36667	6.9	1	0	1	1
3x33	4x60	Shared	10.0933	2.52	0	1	1	2
3x36	6x48	Shared	13.5733	6.98	0	1	1	2
3x37	5x461	Shared	8.81	1.32	0	0	2	1
E2.Q192	E2.S190	nop_off	8.18	0	0	1	1	2
E2.E203	E2.Q192	nop_off	5.09667	0	0	0	2	1
5x44	6x52	Shared	5.07333	7.03	0	0	2	1
5x461	6x52	Shared	4.81333	10.11	1	0	1	1
5x47	6x52	Shared	20.3	5.86	0	0	2	1
6x48	6x51	nop_off	7.36	0	1	1	2	1
6x48	7x41	nop_off	10.79	0	1	1	2	2
6x48	7x42	nop_off	3.53667	0	1	1	2	1
6x55	6x58	nop_off	3.34667	0	0	0	1	1
6x58	E3.Q291	nop_off	4.69333	0	0	1	1	1
E3.P292	E3.Q291	nop_off	7.37333	0	0	1	1	1
7x38	7x42	Shared	4.16	2.5	0	0	2	1
6x58	7x34	nop_off	3.10333	0	0	1	1	2
5x43	5x461	nop_off	3.1	0	0	1	1	1
E2.E194	E2x51	nop_off	3.09333	0	0	1	1	1
3x29	E2x52	Shared	3.07	3.07	0	1	1	2
E2.E194	E2.E199	nop_off	2.96	0	0	1	1	1
7x31	7x35	nop_off	2.62	0	0	0	1	2
E2.D195	E2.E194	Shared	2.6	1.3	0	0	2	1
E2.E194	E2.Q192	Shared	2.54667	5.1	0	1	1	1
7x31	NT.L46	nop_off	2.48333	0	0	0	1	2
7x30	E3.P292	Shared	1.87	1.87	0	0	2	1
4x64	E2.S190	nop_off	1.86	0	0	0	2	2
2x66	2x67	nop_off	0.57	0	2	3	2	1
1x39	7x38	nop_on	0	2.5	1	0	2	2
2x53	7x42	nop_on	0	2.52	0	0	2	1
2x56	3x32	nop_on	0	11.56	0	0	2	1
2x59	3x28	nop_on	0	2.62	2	0	2	1
3x28	Lig	nop_on	0	2.62	0	1	1	0
3x33	E2x52	nop_on	0	2.52	0	1	1	2
4x60	E2x52	nop_on	0	3.21	0	1	2	2
4x60	5x39	nop_on	0	3.93	0	1	2	2
E2.E203	E2.S190	nop_on	0	8.62	0	0	2	2
E2.Q192	Lig	nop_on	0	2.71	0	1	1	0
E2.E194	Lig	nop_on	0	10.8	0	1	1	0
E2.E199	E2x51	nop_on	0	2.65	0	1	1	1
E2.E199	Lig	nop_on	0	26.1	0	1	1	0
E2x50	Lig	nop_on	0	5.59	2	1	1	0
E2x51	Lig	nop_on	0	3.12	0	1	1	0
5x39	5x43	nop_on	0	6.28	5	0	2	1
5x43	Lig	nop_on	0	2.51	0	1	1	0
6x51	Lig	nop_on	0	2.62	0	1	1	0
6x54	6x58	nop_on	0	7.03	0	0	2	1
6x54	7x34	nop_on	0	10.96	0	0	2	2
6x58	E3.P292	nop_on	0	9.47	0	1	1	1
6x58	Lig	nop_on	0	7.19	0	1	1	0
E3.Q291	Lig	nop_on	0	8.55	0	0	1	0
E3.P292	Lig	nop_on	0	3.65	0	1	1	0
E3.S293	Lig	nop_on	0	6.01	0	0	1	0
7x34	7x38	nop_on	0	2.95	0	0	2	2
6x51	7x41	nop_on	0	1.84	0	1	1	2
3x29	4x64	nop_on	0	1.76	0	1	1	2
7x31	Lig	nop_on	0	1.7	0	0	1	0
3x36	3x40	nop_on	0	1.51	0	1	1	2
2x67	Lig	nop_on	0	1.5	0	0	1	0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	nop_off	4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
	nop_on	8F7X-NOP-Nociceptin-Gi1/β1/γ2

Network Difference
Value	nop_off	nop_on
I_min	3.17667	2.48
Number of Linked Nodes	270	251
Number of Specific Nodes	24 (8.89%)	5 (1.99%)
Number of Shared Nodes	246 (91.11%)	246 (98.01%)
Number of Links	291	266
Number of Specific Links	149 (51.20%)	124 (46.62%)
Number of Shared Links	142 (48.80%)	142 (53.38%)
Number of Hubs	27	23
Number of Specific Hubs	16 (59.26%)	12 (52.17%)
Number of Shared Hubs	11 (40.74%)	11 (47.83%)
Average % Shared Neighbours (Jaccard)	37.84
Average % Shared Neighbours (Otsuka)	46.50
Average % Shared Neighbours (Overlap Coefficient)	55.92
Average % Shared Cliques (k3-6)	78.41
Graphlets Similarity	0.457506

Paths Difference
Value	nop_off	nop_on
Number Of Nodes in MetaPath	73	91
Specific Nodes in MetaPath	31 (42.47%)	49 (53.85%)
Shared Nodes in MetaPath	246 (91.11%)	246 (91.11%)
Number Of Links MetaPath	76	99
Specific Links in MetaPath	55 (72.37%)	78 (78.79%)
Shared Links in MetaPath	142 (48.80%)	142 (48.80%)
Number of Shortest Paths	56756	37861
Length Of Smallest Path	3	3
Average Path Length	15.2646	12.622
Length of Longest Path	34	27
Minimum Path Strength	0.638333	1.4
Average Path Strength	6.12225	5.0537
Maximum Path Strength	17.9433	18.21
Minimum Path Correlation	0.7	0.7
Average Path Correlation	0.921481	0.92271
Maximum Path Correlation	0.99	0.99
Minimum % Of Corr. Nodes	3.7037	4.54545
Average % Of Corr. Nodes	46.8626	47.9901
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	34.3763	31.532
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

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