Orange: nodes, hubs and links specific of nop_on_gp network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of nop_off network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.


Index Hub Owner nop_on_gp Avg Int. Strength nop_off Avg Int. Strength nop_on_gp Num Of Links nop_off Num Of Links ConSurf
11x35 nop_on_gp4.41757.225425
21x53 nop_on_gp2.6953.05667419
31x57 nop_on_gp3.07255.34333427
42x50 nop_on_gp6.1356.87222439
52x64 nop_on_gp5.15753.45434
63x29 nop_on_gp3.1084.96444534
73x33 nop_on_gp3.927511.905424
8I2x57 nop_on_gp4.3347.89525
9E2x50 nop_on_gp7.62755.69333439
10E2x52 nop_on_gp2.963.055424
115x47 nop_on_gp4.36258.93444438
125x51 nop_on_gp2.8451.68333426
135x64 nop_on_gp2.3551.85667415
14I3.L247 nop_on_gp3.8255.19435
157x45 nop_on_gp5.2957.54333639
167x53 nop_on_gp4.052510.0689439
17G.HN.11 nop_on_gp3.160402
18G.HN.33 nop_on_gp2.10250404
19G.S1.02 nop_on_gp5.21750405
20G.S1.07 nop_on_gp4.2120509
21G.H1.01 nop_on_gp5.86250409
22G.H1.04 nop_on_gp3.0150407
23G.H1.07 nop_on_gp4.040409
24G.S2.08 nop_on_gp7.840405
25G.S3.03 nop_on_gp8.92750407
26G.S3.06 nop_on_gp8.92250405
27G.s3h2.03 nop_on_gp3.2250409
28G.H2.02 nop_on_gp4.0350408
29G.H2.06 nop_on_gp4.378570709
30G.h2s4.01 nop_on_gp6.8420509
31G.S4.03 nop_on_gp3.8950407
32G.S4.04 nop_on_gp4.4320509
33G.S4.06 nop_on_gp3.8450407
34G.s4h3.03 nop_on_gp5.250408
35G.s4h3.04 nop_on_gp6.626670608
36G.s4h3.05 nop_on_gp6.12750409
37G.s4h3.06 nop_on_gp4.5750408
38G.H3.02 nop_on_gp4.22750408
39G.H3.08 nop_on_gp3.87750409
40G.H3.13 nop_on_gp4.40250405
41G.H3.15 nop_on_gp5.230408
42G.H3.17 nop_on_gp6.412860705
43G.H3.18 nop_on_gp5.350609
44G.S5.02 nop_on_gp3.9050406
45G.S5.03 nop_on_gp3.7340508
46G.S5.04 nop_on_gp3.74250409
47G.S5.05 nop_on_gp4.090609
48G.HG.03 nop_on_gp3.2550406
49G.HG.04 nop_on_gp5.5940509
50G.HG.07 nop_on_gp4.3820509
51G.HG.15 nop_on_gp50407
52G.hgh4.01 nop_on_gp5.2780506
53G.hgh4.02 nop_on_gp5.060607
54G.H4.03 nop_on_gp3.3440504
55G.H4.11 nop_on_gp2.57250407
56G.H4.15 nop_on_gp3.7860508
57G.h4s6.02 nop_on_gp5.040408
58G.h4s6.11 nop_on_gp4.7360507
59G.S6.02 nop_on_gp4.67750407
60G.H5.08 nop_on_gp5.7680508
61G.H5.11 nop_on_gp4.730408
62G.H5.19 nop_on_gp2.81750408
63G.H5.26 nop_on_gp4.890405
64b.1x15 nop_on_gp3.270507
65b.1x19 nop_on_gp4.020406
66b.lhb1x3 nop_on_gp3.733330602
67b.lhb1x11 nop_on_gp4.1520504
68b.l1x3 nop_on_gp8.3140509
69b.b2x1 nop_on_gp5.55250408
70b.b2x5 nop_on_gp6.0650607
71b.b4x2 nop_on_gp5.580408
72b.b4x4 nop_on_gp7.5150408
73b.b4x5 nop_on_gp4.20750407
74b.b4x6 nop_on_gp10.7760509
75b.l4x2 nop_on_gp9.3150404
76b.b5x2 nop_on_gp5.04250407
77b.b5x3 nop_on_gp5.760709
78b.b5x7 nop_on_gp5.0750407
79b.l5x1 nop_on_gp3.82750408
80b.l5x5 nop_on_gp8.716670609
81b.b6x5 nop_on_gp4.2050606
82b.l6x5 nop_on_gp5.51750404
83b.b7x1 nop_on_gp6.4850404
84b.l7x2 nop_on_gp3.73750409
85b.b8x4 nop_on_gp4.110706
86b.b9x3 nop_on_gp6.57250406
87b.l9x3 nop_on_gp5.740709
88b.l9x6 nop_on_gp3.998750808
89b.l9x7 nop_on_gp3.0220507
90b.b10x5 nop_on_gp2.7350409
91b.l10x1 nop_on_gp3.760403
92b.b11x4 nop_on_gp4.990409
93b.b11x6 nop_on_gp6.6550409
94b.l11x2 nop_on_gp5.9660509
95b.b12x5 nop_on_gp5.12250406
96b.b12x6 nop_on_gp8.801670608
97b.b13x7 nop_on_gp7.20607
98b.l13x3 nop_on_gp8.093330609
99b.l13x6 nop_on_gp5.1740509
100b.l13x7 nop_on_gp4.6540509
101b.b14x1 nop_on_gp3.960408
102b.b15x1 nop_on_gp5.4840509
103b.l15x1 nop_on_gp4.6940507
104b.l15x2 nop_on_gp5.180509
105b.b16x4 nop_on_gp11.16750406
106b.b16x5 nop_on_gp5.3120505
107b.b16x6 nop_on_gp7.921430708
108b.b17x5 nop_on_gp9.6450407
109b.b17x7 nop_on_gp9.5050408
110b.l17x3 nop_on_gp7.2950609
111b.b18x5 nop_on_gp5.8250405
112b.l18x1 nop_on_gp5.502860706
113b.l18x2 nop_on_gp5.320407
114b.l18x3 nop_on_gp7.290405
115b.b19x2 nop_on_gp4.940606
116b.b19x4 nop_on_gp4.8580508
117b.l19x2 nop_on_gp5.7750409
118b.b20x4 nop_on_gp6.990608
119b.b20x6 nop_on_gp7.4340506
120b.b20x7 nop_on_gp4.47750409
121b.l20x2 nop_on_gp6.34250409
122b.b21x1 nop_on_gp10.37250407
123b.b21x7 nop_on_gp3.4820505
124b.l21x5 nop_on_gp2.9980504
125b.l21x7 nop_on_gp3.830405
126b.b22x5 nop_on_gp4.3040507
127b.l22x5 nop_on_gp6.380609
128b.b23x3 nop_on_gp4.810407
129b.b23x6 nop_on_gp5.705710707
130b.b24x2 nop_on_gp6.2550405
131b.b24x4 nop_on_gp7.770406
132b.b24x5 nop_on_gp4.23750405
133b.b24x7 nop_on_gp6.57250409
134b.l24x2 nop_on_gp6.8650406
135b.l24x3 nop_on_gp6.140505
136b.b25x3 nop_on_gp5.6060505
137b.b25x6 nop_on_gp3.70403
138b.l25x3 nop_on_gp7.7760509
139b.l25x6 nop_on_gp11.160408
140b.l27x1 nop_on_gp9.950609
141b.l27x2 nop_on_gp7.380409
142b.b28x2 nop_on_gp5.60404
143b.b28x4 nop_on_gp5.11250406
144b.b28x6 nop_on_gp7.260509
145g.h1x10 nop_on_gp3.780409
146g.h1x11 nop_on_gp2.7950409
147g.h1x14 nop_on_gp4.01750409
148g.l1x4 nop_on_gp4.09250408
149g.h2x11 nop_on_gp9.61750406
150g.ctx3 nop_on_gp6.4280509
151g.ctx6 nop_on_gp4.070506
152g.ctx14 nop_on_gp4.9460509
153g.ctx16 nop_on_gp6.225710708
1541x36 Shared5.043.67083444
1551x39 Shared4.01254.15133457
1562x42 Shared5.066676.29267657
157E1x50 Shared9.3056.60222668
158E1x52 Shared9.8169.90733556
1593x34 Shared6.14.844455
1605x58 Shared4.843336.83133659
1616x44 Shared3.7258.27917449
1626x48 Shared5.59258.87833468
1636x52 Shared6.9210.2642447
1647x42 Shared5.03256.04048476
165Lig Shared7.238710.167323100
1661x42 nop_off3.23.89417247
1671x47 nop_off3.886673.0525346
1682x40 nop_off7.196.21083248
1692x41 nop_off3.5953.26133256
1702x45 nop_off8.816679.75583349
1712x57 nop_off6.4854.4975247
1723x41 nop_off1.264.12083145
1733x50 nop_off3.6055.27042289
1744x49 nop_off1.973334.36667346
1754x50 nop_off12.535.47083349
176E2.E194 nop_off5.733332.8341
1775x35 nop_off4.563337.02354
1785x461 nop_off5.7155.09917246
1796x49 nop_off2.993333.4346
1808x50 nop_off3.656676.55111368
   
Orange: nodes, hubs and links specific of nop_on_gp network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of nop_off network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Owner nop_on_gp Recurrence nop_off Recurrence nop_on_gp Hub1? nop_off Hub1? nop_on_gp Hub2? nop_off Hub2? ConSurf1 ConSurf2
17x45 7x48 nop_on_gp10.61170YesNoNoNo96
27x48 7x51 nop_on_gp10.09920NoNoNoNo66
33x43 7x53 nop_on_gp53.41130NoNoYesNo89
43x46 7x53 nop_on_gp60.76290NoNoYesNo99
52x42 3x49 nop_on_gp66.38320YesYesNoNo78
63x49 I2x57 nop_on_gp66.60620NoNoYesNo85
7G.H5.19 I2x57 nop_on_gp67.49720YesNoYesNo85
8G.H5.19 I2x50 nop_on_gp45.20210YesNoNoNo87
9G.H5.16 I2x50 nop_on_gp45.34180NoNoNoNo67
105x68 G.H5.16 nop_on_gp44.93960NoNoNoNo66
115x68 I3.L247 nop_on_gp49.2310NoNoYesNo65
12G.H5.13 I3.L247 nop_on_gp49.76640NoNoYesNo85
13G.H5.13 G.S6.02 nop_on_gp49.90490NoNoYesNo87
14G.H5.06 G.S6.02 nop_on_gp25.6210NoNoYesNo37
15G.H5.06 G.S5.03 nop_on_gp25.60180NoNoYesNo38
16G.S4.03 G.S5.03 nop_on_gp51.22420YesNoYesNo78
17G.S1.06 G.S4.03 nop_on_gp76.37160NoNoYesNo87
18G.H1.01 G.S1.06 nop_on_gp76.41130YesNoNoNo98
19G.H1.01 G.s1h1.01 nop_on_gp76.48690YesNoNoNo99
20G.S1.07 G.s1h1.01 nop_on_gp53.91430YesNoNoNo99
21G.S1.07 G.S4.02 nop_on_gp42.40320YesNoNoNo98
22G.H3.18 G.S4.02 nop_on_gp42.02170YesNoNoNo98
23G.H3.17 G.H3.18 nop_on_gp41.64360YesNoYesNo59
24G.H3.17 b.l25x6 nop_on_gp56.40580YesNoYesNo58
25b.l23x1 b.l25x6 nop_on_gp1000NoNoYesNo68
26b.l21x7 b.l23x1 nop_on_gp99.79740YesNoNoNo56
27b.b23x6 b.l21x7 nop_on_gp73.64480YesNoYesNo75
28b.b23x6 b.b24x4 nop_on_gp26.93960YesNoYesNo76
29b.b24x4 b.b25x6 nop_on_gp26.41540YesNoYesNo63
30b.b25x5 b.b25x6 nop_on_gp50.85670NoNoYesNo43
31b.b24x5 b.b25x5 nop_on_gp50.39890YesNoNoNo54
32b.b23x1 b.b24x5 nop_on_gp27.46230NoNoYesNo55
33b.b28x6 b.lhb1x11 nop_on_gp10.63490YesNoYesNo94
34b.b28x4 b.b28x6 nop_on_gp12.22070YesNoYesNo69
35G.H5.10 G.S6.02 nop_on_gp25.54450NoNoYesNo67
36G.H5.10 G.S5.03 nop_on_gp25.60390NoNoYesNo68
37G.H5.15 G.H5.19 nop_on_gp22.8920NoNoYesNo78
38G.H5.11 G.H5.15 nop_on_gp22.95130YesNoNoNo87
39G.H5.11 G.S3.03 nop_on_gp23.05010YesNoYesNo87
40G.S2.06 G.S3.03 nop_on_gp23.4160NoNoYesNo97
41G.H1.08 G.S2.06 nop_on_gp23.47520NoNoNoNo89
42G.H1.04 G.H1.08 nop_on_gp24.16510YesNoNoNo78
43G.H1.04 G.s6h5.01 nop_on_gp24.36120YesNoNoNo79
44G.S5.05 G.s6h5.01 nop_on_gp24.640YesNoNoNo99
45G.S4.03 G.S5.05 nop_on_gp25.06160YesNoYesNo79
46b.l21x7 b.l23x2 nop_on_gp25.74740YesNoNoNo58
47b.b24x2 b.l23x2 nop_on_gp25.56410YesNoNoNo58
48b.b24x2 b.b25x6 nop_on_gp24.85210YesNoYesNo53
49b.b23x3 b.b24x5 nop_on_gp22.13980YesNoYesNo75
50b.b23x3 b.b26x3 nop_on_gp14.12310YesNoNoNo76
51b.b26x3 b.b27x3 nop_on_gp13.17560NoNoNoNo68
52b.b26x1 b.l27x1 nop_on_gp20.63780NoNoYesNo99
53b.b26x1 b.b26x2 nop_on_gp20.45270NoNoNoNo97
54b.b26x2 b.b2x3 nop_on_gp20.26980NoNoNoNo76
55b.b2x3 b.b2x5 nop_on_gp19.89450NoNoYesNo67
56b.b2x5 b.l4x1 nop_on_gp11.99010YesNoNoNo75
57G.S1.07 G.S4.04 nop_on_gp20.2130YesNoYesNo99
58G.H3.08 G.s1h1.01 nop_on_gp22.73550YesNoNoNo99
59G.H3.08 G.S4.04 nop_on_gp14.29970YesNoYesNo99
60G.S4.04 G.S4.06 nop_on_gp15.71990YesNoYesNo97
61G.H4.15 G.S4.06 nop_on_gp14.44410YesNoYesNo87
62G.H3.02 G.H4.15 nop_on_gp13.01720YesNoYesNo88
63G.S4.04 G.S5.04 nop_on_gp15.1650YesNoYesNo99
64G.H4.15 G.S5.04 nop_on_gp14.44590YesNoYesNo89
65G.h2s4.01 b.l7x2 nop_on_gp21.34360YesNoYesNo99
66G.s3h2.03 b.l7x2 nop_on_gp38.41010YesNoYesNo99
67G.s3h2.03 b.l7x4 nop_on_gp13.74990YesNoNoNo99
68G.H2.04 G.H3.08 nop_on_gp12.35920NoNoYesNo99
69G.H2.04 G.H2.07 nop_on_gp12.20760NoNoNoNo99
70G.H2.02 G.H2.07 nop_on_gp12.76550YesNoNoNo89
71b.l7x4 b.l9x5 nop_on_gp12.31140NoNoNoNo98
72b.l11x2 b.l9x5 nop_on_gp11.83190YesNoNoNo98
73b.l11x1 b.l9x6 nop_on_gp42.83340NoNoYesNo98
74b.b11x6 b.l11x1 nop_on_gp47.18440YesNoNoNo99
75G.H2.09 G.H3.17 nop_on_gp21.85030NoNoYesNo85
76G.H2.10 G.h2s4.01 nop_on_gp21.26610NoNoYesNo79
77G.H2.10 b.b2x1 nop_on_gp49.72910NoNoYesNo78
78G.H4.11 G.H4.15 nop_on_gp15.25140YesNoYesNo78
79b.b23x6 b.l21x9 nop_on_gp48.08180YesNoNoNo76
80b.b20x3 b.l21x9 nop_on_gp47.16720NoNoNoNo86
81b.b20x3 b.b21x7 nop_on_gp46.93820NoNoYesNo85
82b.b20x5 b.b21x7 nop_on_gp40.72640NoNoYesNo75
83b.b20x5 b.b21x4 nop_on_gp40.49410NoNoNoNo75
84b.b20x7 b.b21x4 nop_on_gp40.03290YesNoNoNo95
85b.b20x7 b.l20x3 nop_on_gp38.72130YesNoNoNo97
86b.b21x2 b.l20x3 nop_on_gp38.48670NoNoNoNo67
87b.1x19 b.b21x2 nop_on_gp38.0170YesNoNoNo66
88b.1x15 b.1x19 nop_on_gp21.85270YesNoYesNo76
89b.1x15 g.h1x14 nop_on_gp17.83720YesNoYesNo79
90b.1x19 g.l1x4 nop_on_gp15.22320YesNoYesNo68
91b.b23x1 g.ctx6 nop_on_gp20.96860NoNoYesNo56
92b.l22x5 g.ctx6 nop_on_gp21.98040YesNoYesNo96
93b.h2x1 b.h2x5 nop_on_gp13.89590NoNoNoNo55
94b.b2x1 b.l1x6 nop_on_gp28.40590YesNoNoNo89
95b.l1x6 b.l27x1 nop_on_gp28.39560NoNoYesNo99
96b.l3x1 b.l5x5 nop_on_gp28.73780NoNoYesNo99
97b.l5x3 b.l5x5 nop_on_gp19.57490NoNoYesNo89
98b.l5x3 b.l7x3 nop_on_gp19.27320NoNoNoNo89
99b.l7x3 b.l7x5 nop_on_gp18.97140NoNoNoNo96
100b.b9x3 b.l7x5 nop_on_gp18.36740YesNoNoNo66
101b.b6x1 b.l7x2 nop_on_gp24.07820NoNoYesNo99
102b.b17x6 g.h1x14 nop_on_gp10.29030NoNoYesNo79
103b.b16x4 b.b17x6 nop_on_gp10.04350YesNoNoNo67
104b.b13x7 b.b16x6 nop_on_gp10.06030YesNoYesNo78
105b.b11x6 b.l9x3 nop_on_gp23.76180YesNoYesNo99
106b.b11x4 b.l9x3 nop_on_gp24.94530YesNoYesNo99
107b.b11x2 b.b11x4 nop_on_gp40.80510NoNoYesNo79
108b.b11x6 b.l9x7 nop_on_gp21.83110YesNoYesNo97
109b.b11x4 b.l9x7 nop_on_gp17.79340YesNoYesNo97
110b.b11x2 b.l12x1 nop_on_gp31.09490NoNoNoNo76
111b.b8x3 b.l12x1 nop_on_gp25.26720NoNoNoNo66
112b.b7x1 b.b8x3 nop_on_gp21.38070YesNoNoNo46
113b.b7x1 b.b8x5 nop_on_gp11.66450YesNoNoNo44
114b.b21x1 g.l1x4 nop_on_gp14.81750YesNoYesNo78
1156x44 7x45 nop_on_gp11.43481.25121YesYesYesNo99
116G.H2.10 b.l5x5 nop_on_gp28.4660NoNoYesNo79
117G.H2.09 b.b2x1 nop_on_gp50.06980NoNoYesNo88
118b.b2x1 b.l3x1 nop_on_gp28.76790YesNoNoNo89
119G.H2.09 b.l27x1 nop_on_gp28.31660NoNoYesNo89
120b.l25x6 b.l27x1 nop_on_gp44.20130YesNoYesNo89
121b.l5x5 b.l7x2 nop_on_gp41.53430YesNoYesNo99
122G.s3h2.03 b.l9x6 nop_on_gp23.68460YesNoYesNo98
123b.b6x1 b.l9x6 nop_on_gp23.68120NoNoYesNo98
1243x36 Lig Shared31.428645.1435NoNoYesYes70
1253x36 6x48 Shared31.669445.072NoNoYesYes78
1266x44 6x48 Shared31.6735100YesYesYesYes98
1273x43 6x44 Shared48.306252.3684NoNoYesYes89
1282x42 3x46 Shared60.989318.811YesYesNoNo79
1296x52 Lig nop_off0.4306217.9852YesYesYesYes70
1301x39 7x42 nop_off021.0203YesYesYesYes76
1311x39 2x64 nop_off2.5885713.1305YesYesYesNo74
1322x54 7x46 nop_off014.0707NoNoNoNo58
1332x53 7x46 nop_off075.6444NoNoNoNo78
1342x53 3x35 nop_off076.892NoNoNoNo78
1353x35 3x39 nop_off078.1325NoNoNoNo89
1363x39 6x44 nop_off079.3658NoNoYesYes99
1376x48 7x42 nop_off060.7407YesYesYesYes86
1381x50 2x50 nop_off3.7726714.178NoNoYesNo99
1392x50 7x46 nop_off062.4674YesNoNoNo98
1401x60 I1x48 nop_off011.1NoNoNoNo55
141I1x48 I1x50 nop_off0.78198512.6765NoNoNoNo57
1422x40 I1x50 nop_off0.52156714.06NoYesNoNo87
1432x40 8x50 nop_off016.902NoYesNoYes88
1447x53 8x50 nop_off033.6003YesNoNoYes98
1457x49 7x53 nop_off036.4709NoNoYesNo99
1462x50 7x49 nop_off0.11499649.3261YesNoNoNo99
1478x47 8x50 nop_off012.294NoNoNoYes88
1483x43 6x41 nop_off051.4139NoNoNoNo87
1495x54 6x41 nop_off050.656NoNoNoNo87
1503x47 5x54 nop_off048.629NoNoNoNo98
1513x47 5x58 nop_off0.2626147.0096NoNoYesYes99
1525x58 6x37 nop_off0.26267721.8854YesYesNoNo97
1533x50 6x37 nop_off012.1117NoYesNoNo97
1542x41 4x46 nop_off1.0376213.1234NoYesNoNo67
1552x45 4x46 nop_off3.880323.2367NoYesNoNo97
1562x45 4x49 nop_off031.1944NoYesNoYes96
1573x41 4x49 nop_off0.25955445.8299NoYesNoYes56
1583x37 3x41 nop_off058.2919NoNoNoYes65
1593x37 5x461 nop_off0.78995759.3787NoNoNoYes66
1605x461 Lig nop_off055.9969NoYesYesYes60
1612x42 4x46 nop_off5.1671116.3658YesYesNoNo77
1622x45 4x50 nop_off2.5901613.6203NoYesNoYes99
1633x38 4x49 nop_off012.9768NoNoNoYes66
1643x38 4x50 nop_off0.25955411.1036NoNoNoYes69
165E1x50 E1x52 nop_off5.3543815.9153YesYesYesYes86
1662x63 E1x50 nop_off2.2898236.9249NoNoYesYes48
1672x63 Lig nop_off2.5437937.9616NoNoYesYes40
1683x25 E1x50 nop_off0.0033880919.9156NoNoYesYes98
1693x29 Lig nop_off4.3224723.7014YesNoYesYes40
1703x29 E2x50 nop_off0.018534920.3482YesNoYesNo49
1713x25 E2x50 nop_off1.0227419.1149NoNoYesNo99
1723x25 E2.A191 nop_off0.76982836.2921NoNoNoNo94
1733x22 E2.A191 nop_off033.5431NoNoNoNo24
1743x22 E2.S190 nop_off0.51332928.0235NoNoNoNo23
1753x34 4x50 nop_off2.0731819.5581YesYesNoYes59
1763x40 3x41 nop_off023.4977NoNoNoYes75
1773x40 5x50 nop_off0.18222622.3251NoNoNoNo78
1785x58 5x61 nop_off5.2295531.0228YesYesNoNo98
1793x51 5x61 nop_off026.5363NoNoNoNo88
1803x51 3x55 nop_off3.9796820.4411NoNoNoNo87
1813x55 3x56 nop_off0.18222617.9459NoNoNoNo76
182E2.Q192 E2.S190 nop_off022.4752NoNoNoNo23
183E2.E194 E2.Q192 nop_off6.64332e-0516.8984NoYesNoNo12
1845x49 5x50 nop_off0.54641321.1454NoNoNoNo58
1855x46 5x49 nop_off019.9585NoNoNoNo45
1865x42 5x46 nop_off016.3551NoNoNoNo34
1875x38 5x42 nop_off015.1396NoNoNoNo33
1885x35 5x38 nop_off012.6515NoYesNoNo43
1895x47 6x52 nop_off2.0647414.9787YesNoYesYes87
1905x47 6x49 nop_off1.3003610.9784YesNoNoYes86
1913x56 I2x50 nop_off015.4292NoNoNoNo67
192I2x50 I3.S249 nop_off014.1601NoNoNoNo74
1936x27 I3.S249 nop_off010.4458NoNoNoNo34
1946x40 7x49 nop_off012.8088NoNoNoNo89
1956x40 7x52 nop_off011.2323NoNoNoNo88
1966x55 Lig nop_off0.25948811.5933NoNoYesYes50
1976x55 6x58 nop_off010.3457NoNoNoNo54
1987x42 Lig nop_off060.8909YesYesYesYes60
1993x46 6x37 nop_off018.6716NoNoNoNo97

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Midway



Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Node1Node2OwnerNet1LinkStrengthNet2LinkStrengthComm1Comm2Node1ShellNode2Shell
2x60LigShared12.73679.371210
2x63LigShared7.403335.960210
3x29LigShared8.553335.020210
3x32Lignop_off22.6601010
3x33LigShared13.71678.250210
3x36LigShared11.13679.950210
5x461Lignop_off3.6733301010
6x52LigShared10.874.681210
6x55LigShared6.156679.710010
7x42Lignop_off4.7666701010
1x392x57nop_off4.301022
1x397x42nop_off4.9601021
2x562x60Shared4.723334.250021
2x563x28nop_off6.8733300021
2x577x42Shared8.596678.211021
2x607x42nop_off10.896701211
2x63E1x50Shared8.186678.930212
3x25E1x50Shared4.786675.222222
3x28E1x50Shared3.272.450212
E1x50E2x50Shared6.5314.372221
3x25E2x50Shared7.287.282221
3x29E2x50Shared3.273.270211
3x327x42Shared5.366676.91011
3x334x60Shared10.09332.520212
3x366x48Shared13.57336.980212
3x375x461Shared8.811.320021
E2.Q192E2.S190nop_off8.1800212
E2.E203E2.Q192nop_off5.0966700021
5x446x52Shared5.073337.030021
5x4616x52Shared4.8133310.111011
5x476x52Shared20.35.860021
6x486x51nop_off7.3601221
6x487x41nop_off10.7901222
6x487x42nop_off3.5366701221
6x556x58nop_off3.3466700011
6x58E3.Q291nop_off4.6933300211
E3.P292E3.Q291nop_off7.3733300211
7x387x42Shared4.162.50021
6x587x34nop_off3.1033300212
5x435x461nop_off3.100211
E2.E194E2x51nop_off3.0933300211
3x29E2x52Shared3.073.070212
E2.E194E2.E199nop_off2.9600211
7x317x35nop_off2.6200012
E2.D195E2.E194Shared2.61.30021
E2.E194E2.Q192Shared2.546675.10211
7x31NT.L46nop_off2.4833300012
7x30E3.P292Shared1.871.870021
4x64E2.S190nop_off1.8600022
2x662x67nop_off0.57022021
1x397x38nop_on_gp02.51022
2x537x42nop_on_gp02.520021
2x563x32nop_on_gp011.560021
2x593x28nop_on_gp02.622021
3x28Lignop_on_gp02.620210
3x293x33nop_on_gp02.420211
3x33E2x52nop_on_gp02.520212
4x60E2x52nop_on_gp03.210222
4x605x39nop_on_gp03.930222
E2.E203E2.S190nop_on_gp08.620022
E2.Q192Lignop_on_gp02.710210
E2.E194Lignop_on_gp010.80210
E2.E199E2x51nop_on_gp02.650211
E2.E199Lignop_on_gp026.10210
E2x50Lignop_on_gp05.592210
E2x51Lignop_on_gp03.120210
5x395x43nop_on_gp06.285021
5x43Lignop_on_gp02.510210
6x51Lignop_on_gp02.620210
6x546x58nop_on_gp07.030021
6x547x34nop_on_gp010.960022
6x58E3.P292nop_on_gp09.470211
6x58Lignop_on_gp07.190210
E3.Q291Lignop_on_gp08.550010
E3.P292Lignop_on_gp03.650210
E3.S293Lignop_on_gp06.010010
7x347x38nop_on_gp02.950022
6x517x41nop_on_gp01.840212
3x294x64nop_on_gp01.760212
7x31Lignop_on_gp01.70010
2x67Lignop_on_gp01.50010

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
Id Description
nop_on_gp 8F7X-NOP-Nociceptin-Gi1/β1/γ2
nop_off 4EA3-NOP-PubChem 10296561
5DHG-NOP-C-35
5DHH-NOP-SB-612111
Network Difference
Value nop_on_gp nop_off
Imin 2.38 3.17667
Number of Linked Nodes 820 270
Number of Specific Nodes 572 (69.76%) 22  (8.15%)
Number of Shared Nodes 248 (30.24%) 248  (91.85%)
Number of Links 1009 291
Number of Specific Links 865 (85.73%) 147  (50.52%)
Number of Shared Links 144 (14.27%) 144  (49.48%)
Number of Hubs 165 27
Number of Specific Hubs 153 (92.73%) 15  (55.56%)
Number of Shared Hubs 12 (7.27%) 12  (44.44%)
Average % Shared Neighbours (Jaccard) 12.32
Average % Shared Neighbours (Otsuka) 15.15
Average % Shared Neighbours (Overlap Coefficient) 18.19
Average % Shared Cliques (k3-6) 75.54
Graphlets Similarity 0.53195
Paths Difference
Value nop_on_gp nop_off
Number Of Nodes in MetaPath 121 73
Specific Nodes in MetaPath 112 (92.56%) 64  (87.67%)
Shared Nodes in MetaPath 248 (30.24%) 248  (30.24%)
Number Of Links MetaPath 128 76
Specific Links in MetaPath 123 (96.09%) 71  (93.42%)
Shared Links in MetaPath 144 (14.27%) 144  (14.27%)
Number of Shortest Paths 2692393 56756
Length Of Smallest Path 3 3
Average Path Length 30.3486 15.2646
Length of Longest Path 62 34
Minimum Path Strength 1.29 0.638333
Average Path Strength 5.53749 6.12225
Maximum Path Strength 18.98 17.9433
Minimum Path Correlation 0.7 0.7
Average Path Correlation 0.989244 0.921481
Maximum Path Correlation 1 0.99
Minimum % Of Corr. Nodes 2 3.7037
Average % Of Corr. Nodes 43.4144 46.8626
Maximum % Of Corr. Nodes 100 100
Minimum Path Hubs % 0 0
Average Path Hubs % 53.7043 34.3763
Maximum Path Hubs % 100 100

Details about the values in these tables can be found in the corresponding documentation page .

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download nop_off_on_gp.zip<



You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.



You can also  read or  download a guide explaining the meaning of all files and numerical data.