psnGPCR

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Click on any atom on your molecule and the corresponding residue label will be placed beneath the viewer.

Orange: nodes, hubs and links specific of npy1_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of npy1_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	npy1_off Int. Strength	npy1_on Int. Strength	npy1_off Hub1?	npy1_on Hub1?	npy1_off Hub2?	npy1_on Hub2?	ConSurf1	ConSurf2
1	7x28	NT.C33	npy1_off	6.37	0	No	No	No	No	2	8
2	1x45	7x47	npy1_off	4.76	0	No	No	No	No	5	8
3	1x53	7x53	npy1_off	5.275	0	No	No	Yes	No	9	9
4	1x53	8x50	npy1_off	4.265	0	No	No	Yes	Yes	9	8
5	1x54	2x47	npy1_off	4.645	0	No	No	No	No	7	9
6	1x57	2x40	npy1_off	12.745	0	No	No	No	No	7	8
7	1x57	2x44	npy1_off	6.14	0	No	No	No	No	7	5
8	1x60	I1x50	npy1_off	6.795	0	No	No	No	No	5	7
9	2x40	7x53	npy1_off	8.14	0	No	No	Yes	No	8	9
10	2x41	4x39	npy1_off	5.66	0	No	No	No	No	5	2
11	2x43	7x53	npy1_off	13.9	0	No	No	Yes	No	8	9
12	2x45	3x42	npy1_off	6.705	0	No	No	No	No	9	8
13	2x46	3x39	npy1_off	5.255	0	No	Yes	No	No	9	9
14	2x46	7x49	npy1_off	6.18	0	No	Yes	No	No	9	9
15	2x48	2x52	npy1_off	4.26	0	No	No	No	No	6	7
16	2x49	3x35	npy1_off	6.52	0	No	No	No	No	8	8
17	2x53	3x32	npy1_off	7.165	0	No	No	Yes	Yes	7	6
18	2x59	3x24	npy1_off	6.84	0	No	Yes	No	No	6	6
19	2x60	3x28	npy1_off	7.31	0	No	No	No	No	6	5
20	2x61	2x65	npy1_off	8.525	0	Yes	No	No	No	6	4
21	2x64	7x31	npy1_off	4.39	0	No	No	No	No	4	4
22	2x67	E2.T188	npy1_off	4.335	0	No	No	No	No	4	3
23	E1x51	E1x52	npy1_off	5.895	0	No	No	Yes	Yes	2	7
24	3x25	E2.M179	npy1_off	6.48	0	No	No	No	No	9	4
25	3x30	3x34	npy1_off	7.87	0	Yes	No	No	No	6	5
26	3x30	4x54	npy1_off	4.585	0	Yes	No	No	No	6	4
27	3x30	4x62	npy1_off	12.175	0	Yes	No	No	No	6	5
28	3x32	6x48	npy1_off	7.12	0	Yes	Yes	Yes	Yes	6	8
29	3x33	4x61	npy1_off	5.59	0	No	No	Yes	No	4	5
30	3x36	Lig	npy1_off	8.68	0	No	No	Yes	Yes	7	0
31	3x39	6x44	npy1_off	5.28	0	No	No	No	No	9	9
32	3x41	3x44	npy1_off	7.355	0	Yes	No	No	No	7	7
33	3x41	4x49	npy1_off	5.285	0	Yes	No	No	No	7	7
34	3x41	5x461	npy1_off	6.57	0	Yes	No	No	Yes	7	6
35	3x41	5x50	npy1_off	8.11	0	Yes	No	No	No	7	9
36	3x43	6x41	npy1_off	5.96	0	No	Yes	No	No	8	8
37	3x44	5x54	npy1_off	6.14	0	No	No	No	No	7	8
38	3x46	6x37	npy1_off	4.995	0	No	No	Yes	No	8	8
39	3x49	I2.W148	npy1_off	5.45	0	Yes	Yes	No	No	8	5
40	3x49	I2.P150	npy1_off	6.285	0	Yes	Yes	No	No	8	6
41	3x49	4x41	npy1_off	4.31	0	Yes	Yes	No	No	8	4
42	3x50	6x33	npy1_off	6.89	0	Yes	No	No	No	9	7
43	3x50	6x34	npy1_off	13.86	0	Yes	No	No	No	9	6
44	3x50	6x37	npy1_off	4.86	0	Yes	No	Yes	No	9	8
45	3x52	I2.W148	npy1_off	6.57	0	No	No	No	No	4	5
46	3x54	5x61	npy1_off	6.625	0	No	No	No	No	8	8
47	5x68	I2.P145	npy1_off	4.325	0	No	No	No	No	6	8
48	4x61	Lig	npy1_off	9.055	0	Yes	No	Yes	Yes	5	0
49	4x65	E2x50	npy1_off	4.575	0	No	No	No	No	5	9
50	E2.E182	E2.T180	npy1_off	10.585	0	No	No	No	No	1	3
51	E2.F184	E2x51	npy1_off	4.825	0	Yes	Yes	No	No	1	3
52	E2.D190	E2.K193	npy1_off	4.84	0	No	No	No	No	1	2
53	E2.V197	E2x51	npy1_off	7.865	0	No	No	No	No	4	3
54	E2x52	Lig	npy1_off	4.855	0	No	No	Yes	Yes	4	0
55	5x39	E2.F202	npy1_off	5.675	0	Yes	No	Yes	Yes	6	5
56	5x35	E2.P203	npy1_off	19.825	0	No	No	No	No	3	5
57	5x33	5x36	npy1_off	8.34	0	No	No	Yes	No	1	4
58	5x33	E3.H290	npy1_off	10.715	0	No	No	Yes	No	1	4
59	5x36	E3.H290	npy1_off	12.975	0	Yes	No	Yes	No	4	4
60	5x44	5x48	npy1_off	8.525	0	No	No	No	No	6	5
61	5x47	5x51	npy1_off	7.035	0	Yes	Yes	No	No	8	6
62	5x53	5x57	npy1_off	5.59	0	No	No	No	No	6	7
63	5x54	6x41	npy1_off	6.91	0	No	No	No	No	8	8
64	5x58	6x38	npy1_off	7.035	0	No	Yes	No	No	9	5
65	5x59	5x63	npy1_off	7.535	0	No	No	No	No	4	3
66	6x36	7x53	npy1_off	9.58	0	Yes	No	Yes	No	8	9
67	6x44	6x48	npy1_off	9.02	0	No	No	Yes	Yes	9	8
68	6x48	7x41	npy1_off	7.135	0	Yes	Yes	No	No	8	8
69	6x52	Lig	npy1_off	10.135	0	No	No	Yes	Yes	8	0
70	6x54	6x58	npy1_off	12.325	0	Yes	Yes	Yes	No	5	4
71	6x54	Lig	npy1_off	9.375	0	Yes	Yes	Yes	Yes	5	0
72	6x58	E3.I292	npy1_off	4.395	0	Yes	No	No	No	4	4
73	6x58	7x30	npy1_off	9.615	0	Yes	No	No	Yes	4	3
74	E3.H290	E3.Q291	npy1_off	7.42	0	Yes	No	No	No	4	2
75	7x27	7x30	npy1_off	12.32	0	No	No	No	Yes	1	3
76	7x34	7x38	npy1_off	4.525	0	No	No	Yes	Yes	5	6
77	8x50	8x54	npy1_off	7.915	0	Yes	Yes	No	No	8	5
78	E2.E182	NT.N22	npy1_off	6.575	0	No	No	No	No	1	0
79	E2.Q201	NT.L25	npy1_off	7.32	0	No	No	No	No	3	0
80	7x28	NT.N30	npy1_off	6.3	0	No	No	No	No	2	0
81	NT.D32	NT.H34	npy1_off	5.04	0	No	No	No	No	8	2
82	2x37	I1x49	npy1_off	6.575	0	No	No	No	No	8	5
83	3x52	I2.R149	npy1_off	9.345	0	No	No	No	No	4	5
84	4x38	4x41	npy1_off	6.375	0	No	No	No	No	7	4
85	5x64	5x67	npy1_off	4.265	0	No	Yes	No	No	5	4
86	7x55	8x50	npy1_off	6.965	0	No	No	Yes	Yes	6	8
87	8x57	8x58	npy1_off	6.965	0	No	No	Yes	No	5	5
88	6x36	8x47	npy1_off	4.205	0	Yes	No	No	No	8	8
89	E2.Q201	E2x51	npy1_off	4.1	0	No	No	No	No	3	3
90	1x49	7x50	npy1_off	4.06	0	No	No	No	No	8	9
91	3x41	4x52	npy1_off	3.985	0	Yes	No	No	No	7	5
92	6x39	7x52	npy1_off	3.96	0	No	No	No	Yes	5	8
93	1x60	8x53	npy1_off	3.915	0	No	No	No	No	5	5
94	NT.K21	NT.S19	npy1_off	3.825	0	No	No	No	No	0	0
95	7x51	7x55	npy1_off	3.765	0	No	No	No	No	6	6
96	E2.F184	NT.F28	npy1_off	3.75	0	Yes	Yes	No	No	1	0
97	2x52	3x31	npy1_off	3.725	0	No	No	No	No	7	5
98	2x39	6x37	npy1_off	3.685	0	No	No	Yes	No	7	8
99	7x27	NT.N30	npy1_off	3.655	0	No	No	No	No	1	0
100	2x67	E2.V187	npy1_off	3.65	0	No	No	No	No	4	2
101	1x32	2x65	npy1_off	3.565	0	No	No	No	No	3	4
102	1x35	1x39	npy1_off	3.515	0	No	No	Yes	Yes	7	7
103	E2.P183	E2.T180	npy1_off	3.495	0	No	No	No	No	1	3
104	7x32	7x36	npy1_off	3.46	0	No	No	No	No	2	6
105	2x67	E2.K195	npy1_off	3.455	0	No	No	No	Yes	4	3
106	6x22	6x25	npy1_off	3.45	0	No	No	No	No	3	3
107	1x42	7x47	npy1_off	3.42	0	No	No	No	No	7	8
108	6x43	7x48	npy1_off	3.395	0	No	No	No	No	7	6
109	1x59	1x60	npy1_off	3.39	0	No	No	No	No	5	5
110	1x28	NT.L35	npy1_off	3.285	0	No	No	No	Yes	4	3
111	E2.V187	NT.F28	npy1_off	3.275	0	No	No	No	No	2	0
112	3x50	6x30	npy1_off	3.235	0	Yes	No	No	No	9	7
113	6x51	7x37	npy1_off	3.17	0	No	No	No	No	7	6
114	NT.C33	NT.D31	npy1_off	3.11	0	No	No	No	No	8	5
115	4x40	4x43	npy1_off	3.085	0	No	No	No	No	5	3
116	6x24	6x27	npy1_off	3.06	0	No	No	No	No	2	4
117	3x30	4x59	npy1_off	3.045	0	Yes	No	No	No	6	4
118	E2.F184	E2.L189	npy1_off	3.045	0	Yes	Yes	No	No	1	5
119	4x39	I1x51	npy1_off	3.015	0	No	No	No	No	2	6
120	7x54	8x50	npy1_off	3.01	0	No	No	Yes	Yes	7	8
121	NT.N22	NT.S19	npy1_off	2.98	0	No	No	No	No	0	0
122	6x36	6x40	npy1_off	2.915	0	Yes	No	No	No	8	7
123	1x29	1x32	npy1_off	2.855	0	No	No	No	No	3	3
124	3x54	5x65	npy1_off	2.85	0	No	No	No	No	8	8
125	8x49	I1x50	npy1_off	2.805	0	No	No	No	No	6	7
126	5x42	5x46	npy1_off	2.765	0	No	No	No	No	4	5
127	E2.D181	E2.D194	npy1_off	2.66	0	No	No	No	No	1	5
128	3x48	5x53	npy1_off	2.62	0	No	No	No	No	6	6
129	E3.A294	Lig	npy1_off	2.605	0	No	No	Yes	Yes	1	0
130	5x36	5x37	npy1_off	2.425	0	Yes	No	No	No	4	3
131	5x62	5x63	npy1_off	2.42	0	No	No	No	No	5	3
132	6x32	8x47	npy1_off	2.41	0	No	No	No	No	7	8
133	E2.A191	E2.D190	npy1_off	2.315	0	No	No	No	No	3	1
134	1x42	7x39	npy1_off	2.235	0	No	No	No	No	7	5
135	5x56	5x60	npy1_off	2.18	0	No	No	No	No	4	4
136	4x56	5x461	npy1_off	2.165	0	No	No	No	Yes	5	6
137	1x31	7x32	npy1_off	2.12	0	No	Yes	No	No	4	2
138	3x21	E1x50	npy1_off	2.11	0	No	No	Yes	Yes	8	8
139	E2.Q185	E3.I293	npy1_off	2.06	0	No	No	No	No	2	3
140	6x56	Lig	npy1_off	2.02	0	No	No	Yes	Yes	6	0
141	6x26	6x27	npy1_off	1.975	0	No	No	No	No	4	4
142	5x55	6x42	npy1_off	1.965	0	No	No	No	No	5	5
143	5x33	NT.Q24	npy1_off	1.96	0	No	No	No	No	1	0
144	E3.H290	NT.L26	npy1_off	1.93	0	Yes	No	No	No	4	0
145	I1x48	I1x51	npy1_off	1.855	0	No	No	No	No	6	6
146	E2.D190	E2.Y192	npy1_off	1.725	0	No	No	No	No	1	1
147	3x45	4x45	npy1_off	1.71	0	No	No	No	No	7	5
148	1x47	2x54	npy1_off	1.7	0	No	No	No	No	7	7
149	3x56	I2.G147	npy1_off	1.695	0	No	No	No	No	6	4
150	6x42	6x46	npy1_off	1.6	0	No	No	No	No	5	6
151	4x48	4x52	npy1_off	1.49	0	No	No	No	No	4	5
152	6x26	I2.P145	npy1_off	1.44	0	No	No	No	No	4	8
153	1x51	1x55	npy1_off	1.43	0	No	No	No	No	4	3
154	2x51	2x55	npy1_off	1.43	0	No	No	No	No	8	5
155	E2.V187	NT.E29	npy1_off	1.425	0	No	No	No	No	2	0
156	3x26	4x62	npy1_off	1.41	0	No	No	No	No	7	5
157	6x57	6x58	npy1_off	1.31	0	No	No	Yes	No	4	4
158	6x25	6x28	npy1_off	1.27	0	No	No	No	No	3	4
159	8x54	8x58	npy1_off	1.22	0	No	No	Yes	No	5	5
160	8x55	CT.F337	npy1_off	1.17	0	No	No	No	No	4	4
161	8x58	CT.F337	npy1_off	1.07	0	Yes	No	No	No	5	4
162	1x49	1x52	npy1_off	0.975	0	No	No	No	No	8	6
163	1x28	1x30	npy1_off	0.935	0	No	No	No	No	4	2
164	E3.I293	NT.A27	npy1_off	0.81	0	No	No	No	No	3	0
165	4x44	4x48	npy1_off	0.8	0	No	No	No	No	3	4
166	5x41	5x45	npy1_off	0.795	0	No	No	No	No	5	5
167	2x54	2x57	npy1_off	0.79	0	No	No	Yes	No	7	7
168	1x44	1x48	npy1_off	0.775	0	No	No	No	No	5	5
169	NT.A23	NT.Q24	npy1_off	0.76	0	No	No	No	No	0	0
170	I2.G147	I2.R146	npy1_off	0.75	0	No	No	No	No	4	6
171	5x45	5x46	npy1_off	0.745	0	No	No	No	No	5	5
172	NT.D32	NT.N30	npy1_off	0.675	0	No	No	No	No	8	0
173	8x58	CT.N336	npy1_off	0.605	0	Yes	No	No	No	5	4
174	NT.E20	NT.F18	npy1_off	0.585	0	No	No	No	No	0	0
175	8x52	8x56	npy1_off	0.535	0	No	No	No	No	5	4
176	1x32	NT.L35	Shared	5.71	8.56	No	No	No	Yes	3	3
177	1x28	1x31	Shared	8.39	1.68	No	No	No	Yes	4	4
178	1x33	1x37	Shared	8.525	13.4	No	No	No	No	6	5
179	1x39	2x57	Shared	5.275	2.34	Yes	Yes	Yes	No	7	7
180	1x39	2x61	Shared	21.665	2.06	Yes	Yes	Yes	No	7	6
181	1x39	7x38	Shared	8.165	6.53	Yes	Yes	Yes	Yes	7	6
182	1x39	7x39	Shared	15.24	5.86	Yes	Yes	No	No	7	5
183	1x43	2x57	Shared	5.71	8.56	No	No	Yes	No	7	7
184	1x50	2x47	Shared	5.96	5.96	Yes	Yes	No	No	9	9
185	1x54	2x44	Shared	4.605	4.61	No	No	No	No	7	5
186	1x56	8x50	Shared	6.28	2.51	No	No	Yes	Yes	7	8
187	2x37	2x40	Shared	12.94	8.17	No	No	No	No	8	8
188	2x38	3x49	Shared	10.695	9.98	No	No	Yes	Yes	6	8
189	2x39	3x49	Shared	4.235	12.7	No	No	Yes	Yes	7	8
190	2x41	4x43	Shared	5.44	1.21	No	No	No	No	5	3
191	2x42	3x45	Shared	4.845	6.92	No	No	No	No	7	7
192	2x42	3x46	Shared	5.71	5.71	No	No	No	No	7	8
193	2x45	4x46	Shared	13.455	5.66	No	No	No	No	9	7
194	2x45	4x50	Shared	7.91	4.52	No	No	No	Yes	9	9
195	2x49	3x38	Shared	5.655	4.85	No	No	No	No	8	7
196	2x50	3x39	Shared	4.415	4.42	No	Yes	No	No	9	9
197	2x50	7x46	Shared	6.505	4.34	No	Yes	No	No	9	8
198	2x53	3x35	Shared	5.655	4.85	No	No	No	No	7	8
199	2x551	3x31	Shared	4.56	3.04	No	No	No	No	5	5
200	2x57	7x42	Shared	12.015	8.48	Yes	No	No	Yes	7	7
201	2x58	2x59	Shared	5.055	2.89	No	No	No	Yes	8	6
202	2x59	E1x52	Shared	11.79	2.14	No	Yes	Yes	Yes	6	7
203	2x60	7x38	Shared	11.635	13.69	No	No	Yes	Yes	6	6
204	2x61	7x35	Shared	4.265	2.44	Yes	No	No	Yes	6	4
205	2x63	E1x50	Shared	13.505	8.68	No	No	Yes	Yes	6	8
206	2x64	7x35	Shared	9.58	2.95	No	No	No	Yes	4	4
207	2x66	E1x51	Shared	7.61	3.04	No	No	No	No	3	2
208	E1x49	E2.K195	Shared	18.995	17.03	No	Yes	No	Yes	5	3
209	E1x50	E1x52	Shared	18.04	17.04	Yes	Yes	Yes	Yes	8	7
210	3x25	E1x50	Shared	5.875	9.14	No	No	Yes	Yes	9	8
211	E1x50	E2x50	Shared	8.49	3.92	Yes	Yes	No	No	8	9
212	3x22	E2.M179	Shared	6.09	6.77	No	No	No	No	3	4
213	3x25	E2x50	Shared	7.28	3.64	No	No	No	No	9	9
214	3x29	4x61	Shared	6.5	2.89	No	No	Yes	No	6	5
215	3x29	4x65	Shared	15	3.16	No	No	No	No	6	5
216	3x32	Lig	Shared	5.465	6.4	Yes	Yes	Yes	Yes	6	0
217	3x33	4x57	Shared	6.89	6.89	No	No	No	Yes	4	7
218	3x34	4x57	Shared	4.85	3.23	No	No	No	Yes	5	7
219	3x36	6x48	Shared	10.57	3.52	No	No	Yes	Yes	7	8
220	3x37	5x461	Shared	7.795	4.25	No	Yes	No	Yes	6	6
221	3x38	4x50	Shared	18.39	12.26	No	No	No	Yes	7	9
222	3x40	5x50	Shared	4.235	3.39	No	No	No	No	7	9
223	3x40	6x44	Shared	6.28	3.77	No	No	No	No	7	9
224	3x45	4x49	Shared	4.28	1.43	No	No	No	No	7	7
225	3x49	3x53	Shared	5.305	1.33	Yes	Yes	No	No	8	8
226	3x51	3x55	Shared	14.585	13.26	No	Yes	No	No	7	6
227	3x51	5x60	Shared	7.86	3.93	No	Yes	No	No	7	4
228	3x52	3x56	Shared	6.6	2.64	No	No	No	No	4	6
229	3x55	5x64	Shared	8.14	2.51	No	No	No	Yes	6	5
230	I2.P150	I2.W148	Shared	8.785	13.51	No	No	No	No	6	5
231	4x38	4x40	Shared	7.835	12.05	No	No	No	No	7	5
232	4x39	4x43	Shared	5.81	4.65	No	No	No	No	2	3
233	4x60	5x39	Shared	21.555	6.95	No	No	Yes	No	8	6
234	4x61	5x39	Shared	9.8	7.22	Yes	No	Yes	No	5	6
235	4x63	4x64	Shared	8.465	4.84	No	No	No	No	4	5
236	4x64	E2.F202	Shared	11.86	3.09	No	No	Yes	Yes	5	5
237	4x64	E2.P203	Shared	16.69	15.3	No	No	No	No	5	5
238	4x65	E2x52	Shared	4.57	2.61	No	No	No	No	5	4
239	E2.Q201	E2.V178	Shared	11.46	12.89	No	No	No	No	3	5
240	E2.M179	E2.Y196	Shared	9.58	3.59	No	No	No	No	4	5
241	E2.D181	E2.Y196	Shared	5.75	10.34	No	No	No	No	1	5
242	E2.P183	E2.V197	Shared	6.185	3.53	No	No	No	No	1	4
243	E2.F202	E2x52	Shared	5.375	2.39	Yes	Yes	No	No	5	4
244	E2.F202	E2.P203	Shared	4.33	2.89	Yes	Yes	No	No	5	5
245	5x36	E2.F202	Shared	8.55	7.48	Yes	No	Yes	Yes	4	5
246	5x32	5x34	Shared	4.89	3.26	No	No	No	No	3	1
247	5x32	5x35	Shared	9.765	5.58	No	No	No	No	3	3
248	5x37	6x60	Shared	13.67	9.11	No	No	No	No	3	4
249	5x39	5x43	Shared	11.14	4.69	Yes	No	No	No	6	5
250	5x40	6x59	Shared	12.285	10.12	No	No	No	Yes	5	4
251	5x40	Lig	Shared	7.305	6.47	No	No	Yes	Yes	5	0
252	5x41	6x60	Shared	4.245	2.43	No	No	No	No	5	4
253	5x47	5x48	Shared	7.22	2.06	Yes	Yes	No	No	8	5
254	5x47	6x49	Shared	5.275	7.03	Yes	Yes	No	No	8	6
255	5x47	6x52	Shared	7.49	7.49	Yes	Yes	No	No	8	8
256	5x58	6x37	Shared	4.69	11.72	No	Yes	Yes	No	9	8
257	5x62	5x66	Shared	13.735	1.19	No	No	No	No	5	4
258	5x64	5x68	Shared	4.795	5.33	No	Yes	No	No	5	6
259	6x29	6x32	Shared	5.23	2.33	No	No	No	No	6	7
260	6x32	8x48	Shared	15.47	4.95	No	No	No	No	7	5
261	6x36	7x56	Shared	4.95	2.83	Yes	No	No	No	8	6
262	6x40	7x52	Shared	6.28	5.02	No	No	No	Yes	7	8
263	6x47	7x45	Shared	4.3	6.89	No	No	No	No	8	9
264	6x48	7x45	Shared	6.795	4.94	Yes	Yes	No	No	8	9
265	6x50	7x40	Shared	5.245	5.25	No	No	No	No	9	7
266	6x51	6x55	Shared	6.865	5.49	No	No	No	No	7	5
267	6x54	7x33	Shared	6.7	2.44	Yes	Yes	No	No	5	6
268	6x54	7x34	Shared	9.645	7.5	Yes	Yes	No	No	5	5
269	6x55	Lig	Shared	24.09	16.75	No	No	Yes	Yes	5	0
270	6x58	Lig	Shared	7.985	20.3	Yes	No	Yes	Yes	4	0
271	6x59	Lig	Shared	13.78	8.34	No	Yes	Yes	Yes	4	0
272	7x27	7x29	Shared	4.385	2.92	No	No	No	No	1	3
273	7x34	Lig	Shared	13.025	6.41	No	No	Yes	Yes	5	0
274	7x38	7x42	Shared	12.475	5.25	Yes	Yes	No	Yes	6	7
275	7x48	7x52	Shared	5.24	5.24	No	No	No	Yes	6	8
276	E2.K193	E2.K195	Shared	11.495	8.62	No	No	No	Yes	2	3
277	8x48	8x52	Shared	4.95	7.43	No	No	No	No	5	5
278	E1x49	E1x51	Shared	4.155	2.77	No	Yes	No	No	5	2
279	1x51	2x51	Shared	4.15	2.77	No	No	No	No	4	8
280	1x50	7x50	Shared	4.075	6.52	Yes	Yes	No	No	9	9
281	5x49	5x50	Shared	4.06	4.06	No	No	No	No	5	9
282	2x48	4x50	Shared	4.01	4.01	No	No	No	Yes	6	9
283	3x47	5x58	Shared	4.005	2.67	No	No	No	Yes	9	9
284	3x51	5x61	Shared	3.975	1.33	No	Yes	No	No	7	8
285	5x51	6x45	Shared	3.94	1.58	No	No	No	No	6	6
286	5x55	6x41	Shared	3.93	1.31	No	No	No	No	5	8
287	2x62	E1x52	Shared	3.93	2.62	No	No	Yes	Yes	4	7
288	2x56	3x32	Shared	3.815	9.16	No	No	Yes	Yes	7	6
289	6x50	7x37	Shared	3.77	1.88	No	No	No	No	9	6
290	3x27	3x31	Shared	3.725	1.49	No	No	No	No	5	5
291	6x49	6x53	Shared	3.565	1.43	No	No	No	No	6	5
292	3x55	3x56	Shared	3.54	4.25	No	No	No	No	6	6
293	1x50	2x50	Shared	3.365	4.04	Yes	Yes	No	Yes	9	9
294	3x37	4x53	Shared	3.36	3.36	No	Yes	No	No	6	8
295	3x44	5x53	Shared	3.275	1.31	No	No	No	No	7	6
296	6x47	7x43	Shared	3.27	1.64	No	No	No	No	8	6
297	1x38	7x39	Shared	3.15	1.58	No	No	No	No	6	5
298	6x31	6x35	Shared	2.905	8.72	No	No	No	No	6	6
299	1x54	1x58	Shared	2.85	2.85	No	No	No	No	7	4
300	6x61	E3.I292	Shared	2.835	2.83	No	No	No	No	4	4
301	1x48	1x49	Shared	2.785	3.71	No	No	No	No	5	8
302	1x36	2x61	Shared	2.77	2.77	No	No	Yes	No	5	6
303	1x50	2x51	Shared	2.745	9.61	Yes	Yes	No	No	9	8
304	8x47	8x49	Shared	2.72	8.17	No	No	No	No	8	6
305	8x48	8x51	Shared	2.71	4.07	No	No	No	No	5	8
306	1x40	1x43	Shared	2.645	5.29	No	No	No	No	5	7
307	1x46	7x47	Shared	1.96	1.96	No	No	No	No	7	8
308	2x38	4x42	Shared	1.7	3.39	No	No	No	No	6	7
309	E2.F184	E2.Q185	Shared	1.17	3.51	Yes	Yes	No	No	1	2
310	NT.H34	NT.L35	npy1_on	0	6.43	No	No	No	Yes	2	3
311	2x65	NT.H34	npy1_on	0	2.57	No	No	No	No	4	2
312	1x31	NT.L35	npy1_on	0	4.24	No	Yes	No	Yes	4	3
313	7x32	NT.L35	npy1_on	0	2.77	No	No	No	Yes	2	3
314	1x35	7x35	npy1_on	0	4.15	No	No	No	Yes	7	4
315	1x39	7x35	npy1_on	0	3.52	Yes	Yes	No	Yes	7	4
316	1x47	2x51	npy1_on	0	2.98	No	No	No	No	7	8
317	1x53	1x57	npy1_on	0	7.14	No	No	No	No	9	7
318	1x53	2x47	npy1_on	0	4.5	No	No	No	No	9	9
319	1x56	8x53	npy1_on	0	2.8	No	No	No	No	7	5
320	1x56	8x54	npy1_on	0	7.14	No	No	No	No	7	5
321	1x57	1x58	npy1_on	0	2.85	No	No	No	No	7	4
322	1x57	8x50	npy1_on	0	7.54	No	No	Yes	Yes	7	8
323	1x58	2x44	npy1_on	0	2.98	No	No	No	No	4	5
324	1x59	8x53	npy1_on	0	2.77	No	No	No	No	5	5
325	1x60	8x50	npy1_on	0	4.68	No	No	Yes	Yes	5	8
326	I1x49	I1x51	npy1_on	0	12.79	No	No	No	No	5	6
327	2x37	I1x51	npy1_on	0	6.03	No	No	No	No	8	6
328	2x39	2x43	npy1_on	0	3.04	No	No	No	No	7	8
329	2x40	8x50	npy1_on	0	4.83	No	No	Yes	Yes	8	8
330	2x42	3x49	npy1_on	0	3.98	No	No	Yes	Yes	7	8
331	2x46	2x50	npy1_on	0	8.14	No	Yes	No	Yes	9	9
332	2x46	3x42	npy1_on	0	7.51	No	Yes	No	No	9	8
333	2x46	3x43	npy1_on	0	5.54	No	Yes	No	Yes	9	8
334	2x46	7x53	npy1_on	0	2.34	No	Yes	Yes	No	9	9
335	2x50	7x49	npy1_on	0	5.39	No	Yes	No	No	9	9
336	2x52	3x35	npy1_on	0	4.5	No	No	No	No	7	8
337	2x53	3x36	npy1_on	0	3.07	No	No	No	No	7	7
338	2x55	2x551	npy1_on	0	8.75	No	No	No	No	5	5
339	2x56	7x38	npy1_on	0	2.95	No	No	Yes	Yes	7	6
340	2x56	7x42	npy1_on	0	3.24	No	No	No	Yes	7	7
341	2x59	3x28	npy1_on	0	7.25	No	Yes	No	No	6	5
342	2x59	Lig	npy1_on	0	2.34	No	Yes	Yes	Yes	6	0
343	2x60	3x32	npy1_on	0	2.83	No	No	Yes	Yes	6	6
344	2x60	Lig	npy1_on	0	8.5	No	No	Yes	Yes	6	0
345	2x63	E2x50	npy1_on	0	4.03	No	No	No	No	6	9
346	2x63	Lig	npy1_on	0	17.51	No	No	Yes	Yes	6	0
347	2x64	7x34	npy1_on	0	6.49	No	No	No	No	4	5
348	2x66	E1x49	npy1_on	0	6.57	No	No	No	Yes	3	5
349	2x67	Lig	npy1_on	0	13.47	No	No	Yes	Yes	4	0
350	E1x49	E2.F184	npy1_on	0	2.26	No	Yes	Yes	Yes	5	1
351	E1x50	Lig	npy1_on	0	2.19	Yes	Yes	Yes	Yes	8	0
352	3x24	E1x52	npy1_on	0	4.98	No	No	Yes	Yes	6	7
353	3x28	3x32	npy1_on	0	3.96	No	No	Yes	Yes	5	6
354	3x28	Lig	npy1_on	0	3.96	No	No	Yes	Yes	5	0
355	3x30	4x57	npy1_on	0	3.96	Yes	No	No	Yes	6	7
356	3x37	3x41	npy1_on	0	3.89	No	Yes	Yes	No	6	7
357	3x37	4x56	npy1_on	0	4.8	No	Yes	No	No	6	5
358	3x40	6x48	npy1_on	0	8.22	No	No	Yes	Yes	7	8
359	3x41	5x46	npy1_on	0	2.44	Yes	No	No	No	7	5
360	3x42	3x46	npy1_on	0	3.1	No	No	No	No	8	8
361	3x43	6x44	npy1_on	0	2.44	No	Yes	No	No	8	9
362	3x43	7x49	npy1_on	0	2.75	No	Yes	No	No	8	9
363	3x43	7x53	npy1_on	0	5.86	No	Yes	Yes	No	8	9
364	3x44	5x50	npy1_on	0	3.53	No	No	No	No	7	9
365	3x50	5x58	npy1_on	0	4.12	Yes	No	No	Yes	9	9
366	3x51	5x57	npy1_on	0	5.9	No	Yes	No	No	7	7
367	4x41	I2.W148	npy1_on	0	12.7	No	No	No	No	4	5
368	I2.P150	I2.R149	npy1_on	0	2.88	No	No	No	No	6	5
369	4x46	4x50	npy1_on	0	2.35	No	No	No	Yes	7	9
370	4x56	4x57	npy1_on	0	3.26	No	No	No	Yes	5	7
371	4x59	4x63	npy1_on	0	7.14	No	No	No	No	4	4
372	4x61	E2x52	npy1_on	0	4.78	Yes	No	No	No	5	4
373	E2.T180	E2x51	npy1_on	0	2.59	No	No	No	No	3	3
374	E2.D181	E2.Q185	npy1_on	0	3.92	No	No	No	No	1	2
375	E2.E182	E2.P183	npy1_on	0	7.86	No	No	No	No	1	1
376	E2.E182	E2.N186	npy1_on	0	13.15	No	No	No	No	1	1
377	E2.E182	Lig	npy1_on	0	9.45	No	No	Yes	Yes	1	0
378	E2.P183	Lig	npy1_on	0	5.02	No	No	Yes	Yes	1	0
379	E2.F184	E2.K195	npy1_on	0	3.72	Yes	Yes	No	Yes	1	3
380	E2.F184	E2.V197	npy1_on	0	7.87	Yes	Yes	No	No	1	4
381	E2.F184	Lig	npy1_on	0	2.51	Yes	Yes	Yes	Yes	1	0
382	E2.N186	Lig	npy1_on	0	4.2	No	No	Yes	Yes	1	0
383	E2.T188	E2.V187	npy1_on	0	6.35	No	No	No	No	3	2
384	E2.V187	Lig	npy1_on	0	3.53	No	No	Yes	Yes	2	0
385	E2.D190	E2.T188	npy1_on	0	2.89	No	No	No	No	1	3
386	E2.A191	E2.K193	npy1_on	0	3.21	No	No	No	No	3	2
387	E2.D194	E2.K195	npy1_on	0	2.77	No	No	No	Yes	5	3
388	E2x51	Lig	npy1_on	0	11.67	No	No	Yes	Yes	3	0
389	5x36	6x59	npy1_on	0	5.96	Yes	No	No	Yes	4	4
390	5x36	Lig	npy1_on	0	10.33	Yes	No	Yes	Yes	4	0
391	5x43	5x461	npy1_on	0	9.32	No	No	No	Yes	5	6
392	5x43	Lig	npy1_on	0	3.52	No	No	Yes	Yes	5	0
393	5x44	6x56	npy1_on	0	2.95	No	No	No	No	6	6
394	5x45	5x48	npy1_on	0	9.18	No	No	No	No	5	5
395	5x46	5x461	npy1_on	0	2.66	No	No	No	Yes	5	6
396	5x461	Lig	npy1_on	0	4.51	No	Yes	Yes	Yes	6	0
397	5x47	6x48	npy1_on	0	2.89	Yes	Yes	Yes	Yes	8	8
398	5x51	6x44	npy1_on	0	2.44	No	No	No	No	6	9
399	5x54	5x58	npy1_on	0	4.84	No	No	No	Yes	8	9
400	5x58	5x61	npy1_on	0	2.42	No	Yes	No	No	9	8
401	5x58	6x40	npy1_on	0	2.42	No	Yes	No	No	9	7
402	5x58	6x41	npy1_on	0	5.05	No	Yes	No	No	9	8
403	5x59	5x62	npy1_on	0	2.06	No	No	No	No	4	5
404	5x62	6x34	npy1_on	0	9.3	No	No	No	No	5	6
405	5x63	5x67	npy1_on	0	2.51	No	No	No	No	3	4
406	5x65	5x69	npy1_on	0	9.61	No	No	No	No	8	0
407	5x66	5x70	npy1_on	0	8.39	No	No	No	No	4	0
408	5x66	5x71	npy1_on	0	2.88	No	No	No	No	4	0
409	5x70	6x30	npy1_on	0	13.16	No	No	No	No	0	7
410	5x73	I3.K247	npy1_on	0	4.15	No	No	No	No	0	0
411	6x22	I3.K247	npy1_on	0	4.15	No	No	No	No	3	0
412	6x23	6x25	npy1_on	0	2.33	No	No	No	No	3	3
413	6x23	6x26	npy1_on	0	12.05	No	No	No	No	3	4
414	6x25	6x26	npy1_on	0	3.09	No	No	No	No	3	4
415	6x28	6x29	npy1_on	0	2.87	No	No	No	No	4	6
416	6x32	6x36	npy1_on	0	2.48	No	No	Yes	No	7	8
417	6x48	7x46	npy1_on	0	2.43	Yes	Yes	No	No	8	8
418	6x49	6x50	npy1_on	0	3.28	No	No	No	No	6	9
419	6x51	7x41	npy1_on	0	3.15	No	No	No	No	7	8
420	6x54	7x30	npy1_on	0	2.26	Yes	Yes	No	Yes	5	3
421	6x54	7x37	npy1_on	0	5.59	Yes	Yes	No	No	5	6
422	6x59	6x60	npy1_on	0	2.23	No	Yes	No	No	4	4
423	7x30	E3.I293	npy1_on	0	2.65	No	Yes	No	No	3	3
424	7x30	7x31	npy1_on	0	5.1	No	Yes	No	No	3	4
425	7x30	Lig	npy1_on	0	10.78	No	Yes	Yes	Yes	3	0
426	7x31	Lig	npy1_on	0	9.54	No	No	Yes	Yes	4	0
427	7x49	7x53	npy1_on	0	2.33	No	No	Yes	No	9	9
428	7x51	7x52	npy1_on	0	3.77	No	No	No	Yes	6	8
429	7x55	8x51	npy1_on	0	11.71	No	No	No	No	6	8
430	7x55	8x54	npy1_on	0	2.44	No	No	No	No	6	5
431	8x47	8x50	npy1_on	0	2.42	No	No	Yes	Yes	8	8
432	8x53	8x56	npy1_on	0	3.58	No	No	No	No	5	4
433	8x55	8x56	npy1_on	0	7.03	No	No	No	No	4	4
434	Lig	Lig	npy1_on	0	117.82	Yes	Yes	Yes	Yes	0	0
435	4x44	4x45	npy1_on	0	1.84	No	No	No	No	3	5
436	4x45	4x48	npy1_on	0	1.84	No	No	No	No	5	4
437	1x45	1x46	npy1_on	0	1.71	No	No	No	No	5	7
438	1x53	7x54	npy1_on	0	1.71	No	No	No	No	9	7
439	6x46	6x47	npy1_on	0	1.71	No	No	No	No	6	8
440	1x46	1x50	npy1_on	0	1.7	No	No	Yes	Yes	7	9
441	3x38	4x53	npy1_on	0	1.7	No	No	No	No	7	8
442	7x27	7x28	npy1_on	0	1.69	No	No	No	No	1	2
443	5x56	5x57	npy1_on	0	1.64	No	No	No	No	4	7
444	3x56	I2.P145	npy1_on	0	1.63	No	No	No	No	6	8
445	3x31	3x35	npy1_on	0	1.62	No	No	No	No	5	8
446	1x30	1x31	npy1_on	0	1.61	No	No	No	Yes	2	4
447	2x54	7x42	npy1_on	0	1.61	No	No	No	Yes	7	7
448	3x34	4x54	npy1_on	0	1.6	No	No	No	No	5	4
449	6x27	6x30	npy1_on	0	1.6	No	No	No	No	4	7
450	1x52	8x54	npy1_on	0	1.58	No	No	No	No	6	5
451	6x52	6x56	npy1_on	0	1.57	No	No	No	No	8	6
452	6x39	6x40	npy1_on	0	1.55	No	No	No	No	5	7
453	1x42	1x43	npy1_on	0	1.54	No	No	No	No	7	7
454	6x57	E3.I292	npy1_on	0	1.54	No	No	No	No	4	4
455	7x27	E3.I293	npy1_on	0	1.52	No	No	No	No	1	3
456	1x31	1x34	npy1_on	0	1.51	No	Yes	No	No	4	5
457	3x21	E1x52	npy1_on	0	1.51	No	No	Yes	Yes	8	7
458	1x34	1x35	npy1_on	0	1.47	No	No	No	No	5	7
459	1x54	1x55	npy1_on	0	1.47	No	No	No	No	7	3
460	2x41	4x46	npy1_on	0	1.47	No	No	No	No	5	7
461	5x65	6x30	npy1_on	0	1.47	No	No	No	No	8	7
462	5x65	6x33	npy1_on	0	1.43	No	No	No	No	8	7
463	7x51	7x56	npy1_on	0	1.43	No	No	No	No	6	6
464	6x43	7x52	npy1_on	0	1.39	No	No	No	Yes	7	8
465	E2.L189	E2.N186	npy1_on	0	1.37	No	No	No	No	5	1
466	4x38	4x39	npy1_on	0	1.36	No	No	No	No	7	2
467	3x22	3x26	npy1_on	0	1.35	No	No	No	No	3	7
468	5x69	5x73	npy1_on	0	1.35	No	No	No	No	0	0
469	5x70	6x22	npy1_on	0	1.35	No	No	No	No	0	3
470	4x62	4x65	npy1_on	0	1.33	No	No	No	No	5	5
471	3x54	5x64	npy1_on	0	1.25	No	No	No	Yes	8	5
472	3x53	I2.R149	npy1_on	0	1.21	No	No	No	No	8	5
473	5x64	5x69	npy1_on	0	1.21	No	Yes	No	No	5	0
474	5x67	5x68	npy1_on	0	1.07	No	No	No	No	4	6

Orange: nodes, hubs and links specific of npy1_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of npy1_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	npy1_off Avg Int. Strength	npy1_on Avg Int. Strength	npy1_off Num Of Links	npy1_on Num Of Links	ConSurf
1	2x57	npy1_off	5.9475	6.46	4	3	7
2	2x61	npy1_off	9.30625	2.42333	4	3	6
3	3x30	npy1_off	6.91875	3.96	4	1	6
4	3x41	npy1_off	6.261	3.165	5	2	7
5	3x50	npy1_off	7.21125	4.12	4	1	9
6	4x61	npy1_off	7.73625	4.96333	4	3	5
7	5x36	npy1_off	8.0725	7.92333	4	3	4
8	5x39	npy1_off	12.0425	6.28667	4	3	6
9	6x36	npy1_off	5.4125	2.655	4	2	8
10	6x37	npy1_off	4.5575	11.72	4	1	8
11	6x58	npy1_off	7.126	20.3	5	1	4
12	E3.H290	npy1_off	8.26	0	4	0	4
13	7x53	npy1_off	9.22375	3.51	4	3	9
14	8x58	npy1_off	2.465	0	4	0	5
15	1x39	Shared	10.772	4.062	5	5	7
16	1x50	Shared	4.03625	5.566	4	5	9
17	E1x50	Shared	9.604	8.194	5	5	8
18	E1x52	Shared	9.91375	5.658	4	5	7
19	3x32	Shared	5.89125	5.5875	4	4	6
20	3x49	Shared	6.04667	6.9975	6	4	8
21	E2.F184	Shared	3.1975	3.974	4	5	1
22	E2.F202	Shared	7.158	3.9625	5	4	5
23	5x47	Shared	6.755	4.8675	4	4	8
24	6x48	Shared	8.128	4.4	5	5	8
25	6x54	Shared	9.51125	4.4475	4	4	5
26	7x38	Shared	9.2	7.105	4	4	6
27	8x50	Shared	5.687	4.396	5	5	8
28	Lig	Shared	9.10577	16.9336	13	25	0
29	NT.L35	npy1_on	4.4975	5.5	2	4	3
30	1x31	npy1_on	5.255	2.26	2	4	4
31	2x46	npy1_on	5.7175	5.8825	2	4	9
32	2x50	npy1_on	4.76167	5.266	3	5	9
33	2x59	npy1_on	7.895	3.655	3	4	6
34	E1x49	npy1_on	11.575	7.1575	2	4	5
35	3x37	npy1_on	5.5775	4.075	2	4	6
36	3x43	npy1_on	5.96	4.1475	1	4	8
37	3x51	npy1_on	8.80667	6.105	3	4	7
38	4x50	npy1_on	10.1033	5.785	3	4	9
39	4x57	npy1_on	5.87	4.335	2	4	7
40	E2.K195	npy1_on	11.315	8.035	3	4	3
41	5x461	npy1_on	5.51	5.185	3	4	6
42	5x58	npy1_on	5.24333	4.74857	3	7	9
43	5x64	npy1_on	5.73333	2.575	3	4	5
44	6x59	npy1_on	13.0325	6.6625	2	4	4
45	7x30	npy1_on	10.9675	5.1975	2	4	3
46	7x35	npy1_on	6.9225	3.265	2	4	4
47	7x42	npy1_on	12.245	4.645	2	4	7
48	7x52	npy1_on	5.16	3.855	3	4	8

Orange: nodes, hubs and links specific of npy1_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of npy1_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	npy1_off Recurrence	npy1_on Recurrence	npy1_off Hub1?	npy1_on Hub1?	npy1_off Hub2?	npy1_on Hub2?	ConSurf1	ConSurf2
1	1x39	2x61	npy1_off	14.9327	0.735414	Yes	Yes	Yes	No	7	6
2	1x39	7x38	npy1_off	27.8283	3.21621	Yes	Yes	Yes	Yes	7	6
3	7x34	7x38	npy1_off	36.6421	0	No	No	Yes	Yes	5	6
4	6x58	7x30	npy1_off	10.1321	0	Yes	No	No	Yes	4	3
5	6x58	Lig	npy1_off	13.3198	1.29106	Yes	No	Yes	Yes	4	0
6	2x50	3x39	npy1_off	52.0295	1.1832	No	Yes	No	No	9	9
7	3x39	6x44	npy1_off	54.5822	0	No	No	No	No	9	9
8	6x44	6x48	npy1_off	100	0	No	No	Yes	Yes	9	8
9	3x32	6x48	npy1_off	53.5789	0	Yes	Yes	Yes	Yes	6	8
10	3x32	Lig	npy1_off	54.3028	6.14479	Yes	Yes	Yes	Yes	6	0
11	3x36	6x48	npy1_off	48.8951	9.227	No	No	Yes	Yes	7	8
12	3x36	Lig	npy1_off	48.9053	0	No	No	Yes	Yes	7	0
13	1x53	7x53	npy1_off	12.9058	0	No	No	Yes	No	9	9
14	2x40	7x53	npy1_off	33.8329	0	No	No	Yes	No	8	9
15	1x57	2x40	npy1_off	36.7005	0	No	No	No	No	7	8
16	1x57	2x44	npy1_off	37.6429	0	No	No	No	No	7	5
17	1x54	2x44	npy1_off	38.5801	0.00326851	No	No	No	No	7	5
18	1x54	2x47	npy1_off	40.4394	0	No	No	No	No	7	9
19	1x53	8x50	npy1_off	11.8263	0	No	No	Yes	Yes	9	8
20	6x36	8x47	npy1_off	13.0124	0	Yes	No	No	No	8	8
21	6x36	7x53	npy1_off	20.2438	0	Yes	No	Yes	No	8	9
22	2x39	3x49	npy1_off	33.9243	2.33698	No	No	Yes	Yes	7	8
23	2x39	6x37	npy1_off	34.8895	0	No	No	Yes	No	7	8
24	3x46	6x37	npy1_off	42.0472	0	No	No	Yes	No	8	8
25	2x42	3x45	npy1_off	43.8659	2.34352	No	No	No	No	7	7
26	3x45	4x49	npy1_off	45.6642	1.17339	No	No	No	No	7	7
27	3x41	4x49	npy1_off	46.5735	0	Yes	No	No	No	7	7
28	3x41	5x50	npy1_off	61.7526	0	Yes	No	No	No	7	9
29	3x40	5x50	npy1_off	63.3376	4.63801	No	No	No	No	7	9
30	3x40	6x44	npy1_off	64.1224	4.33077	No	No	No	No	7	9
31	E1x50	E1x52	npy1_off	33.0226	5.20673	Yes	Yes	Yes	Yes	8	7
32	E1x50	E2x50	npy1_off	35.1791	1.32701	Yes	Yes	No	No	8	9
33	4x65	E2x50	npy1_off	41.8237	0	No	No	No	No	5	9
34	4x65	E2x52	npy1_off	41.2979	2.86975	No	No	No	No	5	4
35	E2x52	Lig	npy1_off	56.7793	0	No	No	Yes	Yes	4	0
36	E1x51	E1x52	npy1_off	28.509	0	No	No	Yes	Yes	2	7
37	2x67	E2.K195	npy1_off	20.8128	0	No	No	No	Yes	4	3
38	E1x49	E2.K195	npy1_off	25.6718	0.0359536	No	Yes	No	Yes	5	3
39	E1x49	E1x51	npy1_off	26.6243	1.34009	No	Yes	No	No	5	2
40	4x61	Lig	npy1_off	11.4453	0	Yes	No	Yes	Yes	5	0
41	3x41	3x44	npy1_off	11.0211	0	Yes	No	No	No	7	7
42	3x49	I2.W148	npy1_off	21.082	0	Yes	Yes	No	No	8	5
43	3x55	3x56	npy1_off	14.8844	3.53653	No	No	No	No	6	6
44	3x52	3x56	npy1_off	18.0315	1.1832	No	No	No	No	4	6
45	3x52	I2.W148	npy1_off	20.1041	0	No	No	No	No	4	5
46	E2.F202	E2x52	npy1_off	19.9797	4.10851	Yes	Yes	No	No	5	4
47	2x67	E2.V187	npy1_off	18.8849	0	No	No	No	No	4	2
48	E2.V187	NT.F28	npy1_off	17.0434	0	No	No	No	No	2	0
49	E2.F184	NT.F28	npy1_off	16.124	0	Yes	Yes	No	No	1	0
50	E2.F184	E2x51	npy1_off	11.1938	0	Yes	Yes	No	No	1	3
51	7x34	Lig	Shared	36.0503	48.6517	No	No	Yes	Yes	5	0
52	1x50	2x50	Shared	50.3023	74.7835	Yes	Yes	No	Yes	9	9
53	1x50	2x47	Shared	41.3614	69.2924	Yes	Yes	No	No	9	9
54	2x42	3x46	Shared	42.9591	14.7835	No	No	No	No	7	8
55	5x36	E2.F202	Shared	13.302	10.5475	Yes	No	Yes	Yes	4	5
56	2x50	7x46	npy1_on	1.12268	84.1608	No	Yes	No	No	9	8
57	6x48	7x46	npy1_on	0	84.6576	Yes	Yes	No	No	8	8
58	5x47	6x48	npy1_on	0	96.4765	Yes	Yes	Yes	Yes	8	8
59	5x47	6x49	npy1_on	2.1463	98.4965	Yes	Yes	No	No	8	6
60	6x49	6x50	npy1_on	0	99.1175	No	No	No	No	6	9
61	6x50	7x37	npy1_on	2.1463	99.7124	No	No	No	No	9	6
62	6x54	7x37	npy1_on	0	100	Yes	Yes	No	No	5	6
63	6x54	7x34	npy1_on	1.40462	54.1624	Yes	Yes	No	No	5	5
64	2x64	7x34	npy1_on	0	14.2278	No	No	No	No	4	5
65	2x64	7x35	npy1_on	2.19202	13.5185	No	No	No	Yes	4	4
66	1x53	2x47	npy1_on	0	68.5766	No	No	No	No	9	9
67	1x53	1x57	npy1_on	0	67.1254	No	No	No	No	9	7
68	1x56	8x50	npy1_on	1.11252	57.0453	No	No	Yes	Yes	7	8
69	1x57	8x50	npy1_on	0	63.3829	No	No	Yes	Yes	7	8
70	1x56	8x54	npy1_on	0	52.8779	No	No	No	No	7	5
71	2x42	3x49	npy1_on	0	11.4627	No	No	Yes	Yes	7	8
72	3x42	3x46	npy1_on	0	15.8751	No	No	No	No	8	8
73	2x46	3x42	npy1_on	0	16.9603	No	Yes	No	No	9	8
74	2x46	2x50	npy1_on	0	19.5097	No	Yes	No	Yes	9	9
75	3x38	4x50	npy1_on	6.55829	12.0281	No	No	No	Yes	7	9
76	3x38	4x53	npy1_on	0	14.6298	No	No	No	No	7	8
77	3x37	4x53	npy1_on	1.12268	15.9209	No	Yes	No	No	6	8
78	3x37	5x461	npy1_on	2.24282	25.9454	No	Yes	No	Yes	6	6
79	5x461	Lig	npy1_on	0	28.9394	No	Yes	Yes	Yes	6	0
80	E2.F184	Lig	npy1_on	0	19.3561	Yes	Yes	Yes	Yes	1	0
81	5x36	Lig	npy1_on	0	11.5673	Yes	No	Yes	Yes	4	0
82	5x58	6x40	npy1_on	0	37.5421	No	Yes	No	No	9	7
83	6x40	7x52	npy1_on	4.46787	39.4672	No	No	No	Yes	7	8
84	7x51	7x52	npy1_on	0	42.2814	No	No	No	Yes	6	8
85	7x51	7x56	npy1_on	0	43.2064	No	No	No	No	6	6
86	6x36	7x56	npy1_on	1.1176	44.1216	Yes	No	No	No	8	6
87	6x32	6x36	npy1_on	0	45.0335	No	No	Yes	No	7	8
88	6x32	8x48	npy1_on	4.46533	47.6548	No	No	No	No	7	5
89	8x48	8x51	npy1_on	1.12268	49.4231	No	No	No	No	5	8
90	7x55	8x51	npy1_on	0	50.2958	No	No	No	No	6	8
91	7x55	8x54	npy1_on	0	51.162	No	No	No	No	6	5
92	3x51	5x61	npy1_on	3.35789	29.7075	No	Yes	No	No	7	8
93	5x58	5x61	npy1_on	0	30.7174	No	Yes	No	No	9	8
94	3x51	3x55	npy1_on	6.67259	25.6022	No	Yes	No	No	7	6
95	3x55	5x64	npy1_on	7.36347	21.376	No	No	No	Yes	6	5
96	5x65	5x69	npy1_on	0	11.4496	No	No	No	No	8	0
97	5x64	5x69	npy1_on	0	15.9569	No	Yes	No	No	5	0
98	6x54	7x30	npy1_on	0	46.8769	Yes	Yes	No	Yes	5	3
99	7x30	Lig	npy1_on	0	45.9781	No	Yes	Yes	Yes	3	0

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
2x53	3x32	npy1_off	7.165	0	0	0	2	1
2x58	2x59	Shared	5.055	2.89	0	0	2	1
2x59	E1x52	Shared	11.79	2.14	0	1	1	2
2x59	3x24	npy1_off	6.84	0	0	1	1	2
2x60	3x28	npy1_off	7.31	0	0	1	1	1
2x60	7x38	Shared	11.635	13.69	0	1	1	2
2x63	E1x50	Shared	13.505	8.68	0	1	1	1
2x64	7x31	npy1_off	4.39	0	0	0	2	1
2x67	E2.T188	npy1_off	4.335	0	0	0	1	2
E1x49	E2.K195	Shared	18.995	17.03	0	1	2	2
E1x50	E1x52	Shared	18.04	17.04	5	1	1	2
3x25	E1x50	Shared	5.875	9.14	5	1	2	1
E1x50	E2x50	Shared	8.49	3.92	5	1	1	2
3x25	E2x50	Shared	7.28	3.64	5	1	2	2
3x29	4x61	Shared	6.5	2.89	0	0	2	1
3x29	4x65	Shared	15	3.16	0	0	2	2
3x32	6x48	npy1_off	7.12	0	0	1	1	2
3x32	Lig	Shared	5.465	6.4	0	1	1	0
3x33	4x61	npy1_off	5.59	0	0	0	2	1
3x36	6x48	Shared	10.57	3.52	0	0	1	2
3x36	Lig	npy1_off	8.68	0	0	0	1	0
3x37	5x461	Shared	7.795	4.25	0	0	2	1
3x41	5x461	npy1_off	6.57	0	0	0	2	1
4x61	5x39	Shared	9.8	7.22	0	0	1	2
4x61	Lig	npy1_off	9.055	0	0	0	1	0
4x65	E2x50	npy1_off	4.575	0	0	0	2	2
4x65	E2x52	Shared	4.57	2.61	0	0	2	1
E2.E182	E2.T180	npy1_off	10.585	0	0	1	1	2
E2.P183	E2.V197	Shared	6.185	3.53	0	1	1	2
E2.F184	E2x51	npy1_off	4.825	0	0	1	1	1
E2.V197	E2x51	npy1_off	7.865	0	0	0	2	1
E2.F202	E2x52	Shared	5.375	2.39	2	1	2	1
E2x52	Lig	npy1_off	4.855	0	0	0	1	0
5x36	E2.F202	Shared	8.55	7.48	2	1	1	2
5x39	E2.F202	npy1_off	5.675	0	0	0	2	2
5x33	5x36	npy1_off	8.34	0	2	0	2	1
5x33	E3.H290	npy1_off	10.715	0	2	0	2	2
5x36	E3.H290	npy1_off	12.975	0	2	1	1	2
5x37	6x60	Shared	13.67	9.11	0	0	2	2
5x39	5x43	Shared	11.14	4.69	0	0	2	1
5x40	6x59	Shared	12.285	10.12	1	1	1	1
5x40	Lig	Shared	7.305	6.47	1	1	1	0
5x47	6x52	Shared	7.49	7.49	0	0	2	1
6x51	6x55	Shared	6.865	5.49	0	0	2	1
6x52	Lig	npy1_off	10.135	0	0	0	1	0
6x54	6x58	npy1_off	12.325	0	1	0	1	1
6x54	7x33	Shared	6.7	2.44	1	0	1	2
6x54	7x34	Shared	9.645	7.5	1	0	1	1
6x54	Lig	npy1_off	9.375	0	1	0	1	0
6x55	Lig	Shared	24.09	16.75	0	1	1	0
6x58	E3.I292	npy1_off	4.395	0	1	0	1	2
6x58	7x30	npy1_off	9.615	0	1	0	1	1
6x58	Lig	Shared	7.985	20.3	1	0	1	0
6x59	Lig	Shared	13.78	8.34	1	1	1	0
7x27	7x30	npy1_off	12.32	0	0	0	2	1
7x34	7x38	npy1_off	4.525	0	1	1	1	2
7x34	Lig	Shared	13.025	6.41	1	1	1	0
E2.E182	NT.N22	npy1_off	6.575	0	0	1	1	2
E2.Q201	E2x51	npy1_off	4.1	0	0	0	2	1
2x56	3x32	Shared	3.815	9.16	0	1	2	1
E2.F184	NT.F28	npy1_off	3.75	0	0	1	1	2
2x67	E2.V187	npy1_off	3.65	0	0	0	1	1
E2.P183	E2.T180	npy1_off	3.495	0	0	1	1	2
2x67	E2.K195	npy1_off	3.455	0	0	0	1	2
E2.V187	NT.F28	npy1_off	3.275	0	0	1	1	2
6x51	7x37	npy1_off	3.17	0	0	0	2	2
E2.F184	E2.L189	npy1_off	3.045	0	0	1	1	2
E3.A294	Lig	npy1_off	2.605	0	0	0	1	0
5x36	5x37	npy1_off	2.425	0	2	1	1	2
4x56	5x461	npy1_off	2.165	0	0	0	2	1
3x21	E1x50	npy1_off	2.11	0	0	0	2	1
E2.Q185	E3.I293	npy1_off	2.06	0	0	0	2	2
6x56	Lig	npy1_off	2.02	0	0	0	1	0
E2.V187	NT.E29	npy1_off	1.425	0	0	1	1	2
6x57	6x58	npy1_off	1.31	0	0	0	2	1
E2.F184	E2.Q185	Shared	1.17	3.51	0	1	1	2
2x53	3x36	npy1_on	0	3.07	0	0	2	1
2x56	7x38	npy1_on	0	2.95	0	1	2	2
2x59	3x28	npy1_on	0	7.25	0	1	1	1
2x59	Lig	npy1_on	0	2.34	0	1	1	0
2x60	3x32	npy1_on	0	2.83	0	1	1	1
2x60	Lig	npy1_on	0	8.5	0	1	1	0
2x63	E2x50	npy1_on	0	4.03	0	1	1	2
2x63	Lig	npy1_on	0	17.51	0	1	1	0
2x64	7x34	npy1_on	0	6.49	0	0	2	1
2x67	Lig	npy1_on	0	13.47	0	0	1	0
E1x49	E2.F184	npy1_on	0	2.26	0	1	2	1
E1x50	Lig	npy1_on	0	2.19	5	1	1	0
3x24	E1x52	npy1_on	0	4.98	0	0	2	2
3x28	3x32	npy1_on	0	3.96	0	1	1	1
3x28	Lig	npy1_on	0	3.96	0	1	1	0
3x37	3x41	npy1_on	0	3.89	0	0	2	2
3x37	4x56	npy1_on	0	4.8	0	0	2	2
3x41	5x46	npy1_on	0	2.44	0	0	2	2
4x61	E2x52	npy1_on	0	4.78	0	0	1	1
E2.T180	E2x51	npy1_on	0	2.59	0	0	2	1
E2.E182	E2.P183	npy1_on	0	7.86	0	1	1	1
E2.E182	E2.N186	npy1_on	0	13.15	0	1	1	1
E2.E182	Lig	npy1_on	0	9.45	0	1	1	0
E2.P183	Lig	npy1_on	0	5.02	0	1	1	0
E2.F184	E2.K195	npy1_on	0	3.72	0	1	1	2
E2.F184	E2.V197	npy1_on	0	7.87	0	1	1	2
E2.F184	Lig	npy1_on	0	2.51	0	1	1	0
E2.N186	Lig	npy1_on	0	4.2	0	1	1	0
E2.T188	E2.V187	npy1_on	0	6.35	0	0	2	1
E2.V187	Lig	npy1_on	0	3.53	0	1	1	0
E2x51	Lig	npy1_on	0	11.67	0	1	1	0
5x36	6x59	npy1_on	0	5.96	2	1	1	1
5x36	Lig	npy1_on	0	10.33	2	1	1	0
5x43	5x461	npy1_on	0	9.32	0	1	1	1
5x43	Lig	npy1_on	0	3.52	0	1	1	0
5x44	6x56	npy1_on	0	2.95	0	0	2	1
5x46	5x461	npy1_on	0	2.66	0	0	2	1
5x461	Lig	npy1_on	0	4.51	0	1	1	0
5x47	6x48	npy1_on	0	2.89	0	0	2	2
6x54	7x30	npy1_on	0	2.26	1	0	1	1
6x54	7x37	npy1_on	0	5.59	1	0	1	2
6x59	6x60	npy1_on	0	2.23	1	1	1	2
7x30	E3.I293	npy1_on	0	2.65	0	1	1	2
7x30	7x31	npy1_on	0	5.1	0	1	1	1
7x30	Lig	npy1_on	0	10.78	0	1	1	0
7x31	Lig	npy1_on	0	9.54	0	1	1	0
6x52	6x56	npy1_on	0	1.57	0	0	1	1
6x57	E3.I292	npy1_on	0	1.54	0	0	2	2
7x27	E3.I293	npy1_on	0	1.52	0	0	2	2
3x21	E1x52	npy1_on	0	1.51	0	0	2	2
E2.L189	E2.N186	npy1_on	0	1.37	0	0	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	npy1_off	5ZBH-Y₁-BMS-193885 5ZBQ-Y₁-UR-MK-299
	npy1_on	8K6M-Y₁-Neuropeptide-Y-Gi2/β1/γ1

Network Difference
Value	npy1_off	npy1_on
I_min	4.235	1.88
Number of Linked Nodes	303	273
Number of Specific Nodes	38 (12.54%)	8 (2.93%)
Number of Shared Nodes	265 (87.46%)	265 (97.07%)
Number of Links	309	299
Number of Specific Links	175 (56.63%)	165 (55.18%)
Number of Shared Links	134 (43.37%)	134 (44.82%)
Number of Hubs	28	34
Number of Specific Hubs	14 (50.00%)	20 (58.82%)
Number of Shared Hubs	14 (50.00%)	14 (41.18%)
Average % Shared Neighbours (Jaccard)	30.72
Average % Shared Neighbours (Otsuka)	38.94
Average % Shared Neighbours (Overlap Coefficient)	46.60
Average % Shared Cliques (k3-6)	77.78
Graphlets Similarity	0.47945

Paths Difference
Value	npy1_off	npy1_on
Number Of Nodes in MetaPath	55	49
Specific Nodes in MetaPath	37 (67.27%)	31 (63.27%)
Shared Nodes in MetaPath	265 (87.46%)	265 (87.46%)
Number Of Links MetaPath	55	49
Specific Links in MetaPath	50 (90.91%)	44 (89.80%)
Shared Links in MetaPath	134 (43.37%)	134 (43.37%)
Number of Shortest Paths	62074	49091
Length Of Smallest Path	3	3
Average Path Length	17.0752	18.0512
Length of Longest Path	42	49
Minimum Path Strength	0.77	1.27
Average Path Strength	6.73783	4.89513
Maximum Path Strength	18.935	18.525
Minimum Path Correlation	0.7	0.7
Average Path Correlation	0.930094	0.940054
Maximum Path Correlation	0.99	0.99
Minimum % Of Corr. Nodes	2.5641	2.77778
Average % Of Corr. Nodes	47.1036	54.3306
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	31.6318	38.9574
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

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