psnGPCR

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Orange: nodes, hubs and links specific of npy2_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of npy2_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	npy2_off Int. Strength	npy2_on Int. Strength	npy2_off Hub1?	npy2_on Hub1?	npy2_off Hub2?	npy2_on Hub2?	ConSurf1	ConSurf2
1	1x39	2x60	npy2_off	3.75	0	Yes	Yes	No	No	7	6
2	1x42	7x47	npy2_off	10.05	0	No	No	Yes	No	7	7
3	1x43	2x58	npy2_off	3.39	0	Yes	No	No	No	6	8
4	1x47	2x51	npy2_off	2.98	0	No	No	No	No	6	7
5	1x50	2x47	npy2_off	4.69	0	No	No	No	No	9	9
6	1x53	7x50	npy2_off	3.53	0	No	No	No	No	9	9
7	1x53	7x53	npy2_off	3.79	0	No	No	Yes	Yes	9	9
8	1x56	1x60	npy2_off	5.24	0	No	No	Yes	No	7	5
9	1x56	8x53	npy2_off	5.09	0	No	No	No	No	7	6
10	1x57	2x40	npy2_off	5.91	0	No	No	No	Yes	7	8
11	4x39	I1x48	npy2_off	4.31	0	No	No	No	No	1	6
12	2x39	3x50	npy2_off	6.47	0	No	No	No	No	8	9
13	2x42	3x46	npy2_off	5.02	0	Yes	Yes	No	No	7	9
14	2x46	3x39	npy2_off	3	0	No	Yes	No	No	9	9
15	2x46	3x43	npy2_off	5.54	0	No	Yes	No	No	9	8
16	2x50	7x46	npy2_off	7.23	0	No	Yes	No	No	9	9
17	2x51	2x55	npy2_off	2.95	0	No	No	No	No	7	5
18	2x56	3x28	npy2_off	3.42	0	Yes	No	No	Yes	6	5
19	2x59	3x24	npy2_off	3.65	0	No	No	No	No	5	6
20	2x62	E1x51	npy2_off	9.01	0	No	No	No	No	4	3
21	2x62	E1x52	npy2_off	3.01	0	No	No	Yes	No	4	7
22	2x64	2x65	npy2_off	2.95	0	No	No	Yes	No	4	4
23	E1x50	E2.Y189	npy2_off	3.86	0	Yes	Yes	Yes	Yes	8	5
24	E1x50	Lig	npy2_off	4.2	0	Yes	Yes	Yes	Yes	8	0
25	E1x51	E1x52	npy2_off	7.2	0	No	No	Yes	No	3	7
26	3x32	7x38	npy2_off	8.65	0	No	Yes	Yes	Yes	6	5
27	3x34	4x50	npy2_off	5.69	0	No	No	Yes	Yes	5	9
28	3x37	4x53	npy2_off	4.33	0	Yes	No	Yes	No	6	8
29	3x37	Lig	npy2_off	3.27	0	Yes	No	Yes	Yes	6	0
30	3x39	6x44	npy2_off	3.96	0	No	No	Yes	Yes	9	9
31	3x43	6x41	npy2_off	2.98	0	No	No	No	No	8	8
32	3x44	5x54	npy2_off	6.08	0	No	No	No	No	7	8
33	3x46	6x37	npy2_off	4.28	0	No	No	Yes	No	9	8
34	3x49	I2.I160	npy2_off	7	0	No	No	No	No	8	5
35	3x50	6x33	npy2_off	9.06	0	No	No	No	No	9	8
36	3x50	6x37	npy2_off	4.86	0	No	No	Yes	No	9	8
37	3x51	3x52	npy2_off	5.14	0	Yes	Yes	Yes	No	8	4
38	3x51	5x61	npy2_off	4.84	0	Yes	Yes	No	No	8	8
39	3x52	3x55	npy2_off	3.92	0	Yes	No	No	No	4	7
40	3x52	3x56	npy2_off	6.17	0	Yes	No	Yes	No	4	7
41	3x52	I2.K159	npy2_off	14.85	0	Yes	No	No	No	4	5
42	3x53	6x30	npy2_off	4.18	0	No	No	Yes	Yes	8	7
43	3x54	6x30	npy2_off	13.78	0	No	No	Yes	Yes	8	7
44	3x56	I2.L156	npy2_off	4.69	0	Yes	No	No	No	7	5
45	3x56	I2.K159	npy2_off	8.36	0	Yes	No	No	No	7	5
46	6x26	I2.E157	npy2_off	5.61	0	No	Yes	No	No	4	4
47	6x30	I2.E157	npy2_off	10.47	0	Yes	Yes	No	No	7	4
48	4x39	4x40	npy2_off	3.71	0	No	No	No	No	1	5
49	4x40	4x43	npy2_off	7.48	0	No	No	No	No	5	4
50	4x42	4x43	npy2_off	3.96	0	No	No	No	No	7	4
51	4x48	4x52	npy2_off	4.28	0	No	No	No	No	3	4
52	4x60	5x39	npy2_off	15.3	0	No	No	Yes	Yes	8	6
53	4x61	Lig	npy2_off	5.96	0	No	No	Yes	Yes	5	0
54	4x65	E2x50	npy2_off	4.18	0	Yes	Yes	No	No	6	9
55	4x65	Lig	npy2_off	8.22	0	Yes	Yes	Yes	Yes	6	0
56	E2.E193	E2.I200	npy2_off	5.47	0	No	No	No	No	2	3
57	5x35	E2.P208	npy2_off	9.74	0	No	No	Yes	No	3	4
58	E2.G209	E2.K212	npy2_off	3.49	0	No	No	No	No	4	3
59	5x39	5x43	npy2_off	7.63	0	Yes	Yes	No	No	6	5
60	5x43	Lig	npy2_off	3.69	0	No	No	Yes	Yes	5	0
61	5x44	5x47	npy2_off	3.52	0	Yes	No	No	No	5	8
62	5x44	Lig	npy2_off	3.41	0	Yes	No	Yes	Yes	5	0
63	5x45	5x46	npy2_off	4.28	0	No	No	No	No	5	4
64	5x47	6x52	npy2_off	9.8	0	No	No	Yes	No	8	7
65	5x54	6x41	npy2_off	4.61	0	No	No	No	No	8	8
66	5x56	5x57	npy2_off	3.96	0	No	No	No	No	4	7
67	5x58	6x38	npy2_off	8.83	0	No	Yes	No	No	9	6
68	5x61	6x34	npy2_off	3.04	0	No	No	No	No	8	6
69	5x62	6x35	npy2_off	5.8	0	No	No	No	No	5	6
70	5x65	6x34	npy2_off	2.95	0	No	Yes	No	No	8	6
71	5x68	6x27	npy2_off	15.53	0	No	No	No	No	6	4
72	6x26	6x29	npy2_off	4.12	0	No	Yes	No	No	4	5
73	6x27	6x31	npy2_off	12.36	0	No	No	No	No	4	5
74	6x33	6x37	npy2_off	2.95	0	No	No	Yes	No	8	8
75	6x34	6x35	npy2_off	7.51	0	No	No	No	No	6	6
76	6x36	7x53	npy2_off	8.38	0	No	No	Yes	Yes	8	9
77	6x36	8x47	npy2_off	8.41	0	No	No	No	No	8	8
78	6x39	7x56	npy2_off	6.48	0	No	No	No	No	6	7
79	6x40	7x49	npy2_off	8.87	0	No	No	No	No	8	9
80	6x44	7x45	npy2_off	3.96	0	Yes	Yes	No	No	9	9
81	6x47	7x40	npy2_off	3.27	0	No	No	No	No	8	7
82	6x50	7x40	npy2_off	3.39	0	No	No	No	No	9	7
83	6x51	6x55	npy2_off	7.99	0	No	No	No	No	6	5
84	6x51	7x34	npy2_off	7.31	0	No	No	No	No	6	4
85	6x52	6x55	npy2_off	6.18	0	Yes	No	No	No	7	5
86	6x52	Lig	npy2_off	11.07	0	Yes	No	Yes	Yes	7	0
87	6x54	6x58	npy2_off	11.8	0	Yes	Yes	No	No	4	4
88	6x54	7x34	npy2_off	7.5	0	Yes	Yes	No	No	4	4
89	6x61	E3.V297	npy2_off	4.38	0	No	No	No	No	2	6
90	7x30	E3.V297	npy2_off	6.31	0	Yes	No	No	No	4	6
91	7x26	7x30	npy2_off	3.45	0	No	No	Yes	No	1	4
92	7x27	7x30	npy2_off	5.86	0	No	No	Yes	No	1	4
93	7x27	7x31	npy2_off	4.23	0	No	No	No	No	1	4
94	7x32	7x35	npy2_off	4.42	0	No	No	No	No	1	3
95	7x49	7x53	npy2_off	5.81	0	No	No	Yes	Yes	9	9
96	7x52	7x56	npy2_off	4.24	0	No	Yes	No	No	8	7
97	7x53	8x50	npy2_off	6.95	0	Yes	Yes	Yes	Yes	9	8
98	7x54	8x54	npy2_off	3.01	0	No	No	No	Yes	7	6
99	8x48	8x51	npy2_off	5.27	0	No	No	No	No	5	8
100	8x48	8x52	npy2_off	6.12	0	No	No	No	No	5	4
101	E2.I194	E2.I200	npy2_off	2.94	0	No	No	No	No	1	3
102	1x42	7x42	npy2_off	2.92	0	No	No	No	No	7	7
103	6x33	8x47	npy2_off	2.92	0	No	No	No	No	8	8
104	3x54	5x64	npy2_off	2.91	0	No	No	No	No	8	5
105	1x30	1x33	npy2_off	2.85	0	No	No	No	No	2	6
106	E2.D197	E2.I195	npy2_off	2.8	0	No	No	No	No	4	2
107	2x52	2x551	npy2_off	2.77	0	No	No	No	No	7	5
108	7x27	E3.L298	npy2_off	2.77	0	No	No	No	No	1	1
109	E2.E211	E2.K212	npy2_off	2.7	0	No	No	No	No	2	3
110	3x30	4x54	npy2_off	2.67	0	No	No	No	No	6	4
111	5x65	6x31	npy2_off	2.66	0	No	Yes	No	No	8	5
112	8x56	8x59	npy2_off	2.64	0	No	No	No	No	4	3
113	7x26	7x29	npy2_off	2.6	0	No	No	No	No	1	3
114	2x49	4x50	npy2_off	2.59	0	No	No	Yes	Yes	8	9
115	7x47	7x51	npy2_off	2.44	0	Yes	No	No	No	7	7
116	6x29	8x49	npy2_off	2.41	0	No	No	No	No	5	6
117	2x52	4x50	npy2_off	2.28	0	No	No	Yes	Yes	7	9
118	E2.G209	E2.P208	npy2_off	2.03	0	No	No	Yes	No	4	4
119	3x33	4x57	npy2_off	1.95	0	No	No	No	No	4	7
120	2x56	3x31	npy2_off	1.81	0	Yes	No	No	No	6	5
121	7x35	Lig	npy2_off	1.81	0	No	No	Yes	Yes	3	0
122	6x43	6x47	npy2_off	1.71	0	No	No	No	No	6	8
123	1x56	8x57	npy2_off	1.7	0	No	No	No	No	7	4
124	1x40	1x43	npy2_off	1.64	0	No	No	Yes	No	4	6
125	1x54	2x47	npy2_off	1.62	0	No	No	No	No	7	9
126	E2.A202	E2.I192	npy2_off	1.62	0	No	No	No	No	4	2
127	5x38	5x42	npy2_off	1.62	0	No	No	No	No	4	3
128	5x55	5x59	npy2_off	1.6	0	No	No	No	No	5	3
129	6x41	6x42	npy2_off	1.6	0	No	No	No	No	8	4
130	1x37	1x40	npy2_off	1.59	0	No	No	No	No	6	4
131	5x37	5x38	npy2_off	1.59	0	No	No	No	No	3	4
132	3x41	4x53	npy2_off	1.55	0	No	No	Yes	No	5	8
133	1x43	1x47	npy2_off	1.54	0	Yes	No	No	No	6	6
134	I1x49	I1x50	npy2_off	1.53	0	No	No	Yes	Yes	5	8
135	1x51	2x51	npy2_off	1.5	0	No	No	No	No	4	7
136	E2.L191	E2.S190	npy2_off	1.5	0	No	No	No	No	3	1
137	1x31	7x32	npy2_off	1.49	0	No	No	No	No	4	1
138	1x34	1x35	npy2_off	1.49	0	No	No	No	No	5	5
139	3x23	3x27	npy2_off	1.49	0	No	No	No	No	2	5
140	E2.L191	E2.V201	npy2_off	1.49	0	No	No	No	No	3	4
141	5x44	6x56	npy2_off	1.38	0	Yes	No	No	No	5	5
142	E1x49	E2.I200	npy2_off	1.37	0	No	No	No	No	5	3
143	7x36	7x37	npy2_off	1.31	0	No	No	Yes	No	6	6
144	E1x49	E2.E199	npy2_off	1.27	0	No	No	No	No	5	4
145	1x31	1x35	Shared	2.98	1.49	No	No	No	No	4	5
146	1x32	2x65	Shared	6.65	7.985	No	No	Yes	No	4	4
147	1x36	2x65	Shared	8.56	2.85	No	No	Yes	No	6	4
148	1x39	2x61	Shared	3.52	10.55	Yes	Yes	No	No	7	6
149	1x39	7x38	Shared	8.71	7.62	Yes	Yes	Yes	Yes	7	5
150	1x39	7x39	Shared	10.88	7.855	Yes	Yes	No	No	7	5
151	1x43	2x57	Shared	4.28	6.425	Yes	No	No	Yes	6	7
152	1x44	1x48	Shared	7.14	2.85	No	No	No	No	5	4
153	1x45	7x47	Shared	8.53	2.435	No	No	Yes	No	6	7
154	1x46	2x54	Shared	3.39	3.39	No	No	No	Yes	7	6
155	1x49	7x50	Shared	4.06	2.03	No	No	No	No	8	9
156	1x50	2x50	Shared	5.39	3.365	No	No	No	Yes	9	9
157	1x50	7x50	Shared	9.77	8.145	No	No	No	No	9	9
158	1x52	8x54	Shared	9.74	2.44	No	No	No	Yes	7	6
159	1x52	8x58	Shared	8.53	3.045	No	No	No	No	7	5
160	1x53	2x47	Shared	3.39	3.39	No	No	No	No	9	9
161	1x54	2x48	Shared	4.61	3.07	No	No	No	No	7	6
162	1x55	1x59	Shared	3.93	5.24	No	No	No	No	4	5
163	1x57	2x44	Shared	5.09	0.85	No	No	No	No	7	6
164	1x60	I1x50	Shared	4.98	1.865	Yes	No	Yes	Yes	5	8
165	1x60	8x56	Shared	3.96	2.64	Yes	No	No	No	5	4
166	I1x48	I1x51	Shared	13.61	4.95	No	No	No	No	6	6
167	8x50	I1x50	Shared	8.38	5.985	Yes	Yes	Yes	Yes	8	8
168	8x53	I1x50	Shared	3.22	2.415	No	No	Yes	Yes	6	8
169	2x37	2x40	Shared	7.31	5.12	No	No	No	Yes	7	8
170	2x38	2x42	Shared	3.93	2.62	No	Yes	Yes	Yes	6	7
171	2x38	4x39	Shared	3.04	2.275	No	Yes	No	No	6	1
172	2x38	4x42	Shared	4.85	7.275	No	Yes	No	No	6	7
173	2x40	8x50	Shared	11.63	6.395	No	Yes	Yes	Yes	8	8
174	2x41	4x43	Shared	9.65	2.145	No	No	No	No	5	4
175	2x42	3x45	Shared	5.24	7.87	Yes	Yes	No	No	7	7
176	2x42	4x46	Shared	5.02	5.02	Yes	Yes	No	Yes	7	7
177	2x43	7x53	Shared	12.09	2.42	No	No	Yes	Yes	8	9
178	2x43	8x50	Shared	4.84	7.855	No	No	Yes	Yes	8	8
179	2x45	3x42	Shared	8.77	2.92	No	No	No	No	9	8
180	2x45	4x46	Shared	15.58	7.79	No	No	No	Yes	9	7
181	2x45	4x50	Shared	7.91	6.78	No	No	Yes	Yes	9	9
182	2x46	3x42	Shared	5.9	5.9	No	Yes	No	No	9	8
183	2x53	2x56	Shared	3.42	5.12	No	No	Yes	No	7	6
184	2x54	7x46	Shared	10.24	13.16	No	Yes	No	No	6	9
185	2x56	3x32	Shared	9.16	7.63	Yes	No	No	Yes	6	6
186	2x57	7x42	Shared	8.48	8.485	No	Yes	No	No	7	7
187	2x59	E1x52	Shared	7.46	3.11	No	No	Yes	No	5	7
188	2x60	Lig	Shared	9.97	16.15	No	No	Yes	Yes	6	0
189	2x61	2x65	Shared	4.15	4.845	No	No	Yes	No	6	4
190	2x63	E1x50	Shared	8.68	10.13	No	No	Yes	Yes	5	8
191	2x63	Lig	Shared	3.6	20.075	No	No	Yes	Yes	5	0
192	2x66	E1x51	Shared	10.08	3.6	No	No	No	No	4	3
193	E1x49	E2.V201	Shared	4.28	2.85	No	No	No	No	5	4
194	E1x50	E1x52	Shared	10.47	12.215	Yes	Yes	Yes	No	8	7
195	3x25	E1x50	Shared	5.22	3.265	No	Yes	Yes	Yes	9	8
196	3x24	E1x52	Shared	4.24	4.945	No	No	Yes	No	6	7
197	3x21	3x22	Shared	4.06	4.06	No	No	No	No	8	3
198	3x22	E2.Y189	Shared	18.08	9.735	No	No	Yes	Yes	3	5
199	3x25	E2.Y189	Shared	4.03	2.015	No	Yes	Yes	Yes	9	5
200	3x25	E2x50	Shared	7.28	7.28	No	Yes	No	No	9	9
201	3x26	4x65	Shared	3.39	1.13	No	No	Yes	Yes	7	6
202	3x28	3x29	Shared	3.53	3.53	No	Yes	No	No	5	5
203	3x29	4x65	Shared	12.97	10.81	No	No	Yes	Yes	5	6
204	3x30	4x62	Shared	4	1.33	No	No	No	No	6	5
205	3x32	Lig	Shared	11.46	6.745	No	Yes	Yes	Yes	6	0
206	3x33	Lig	Shared	4.21	2.89	No	No	Yes	Yes	4	0
207	3x34	4x53	Shared	4.5	3	No	No	Yes	No	5	8
208	3x36	6x48	Shared	6.13	3.675	No	No	Yes	Yes	7	8
209	3x36	Lig	Shared	8.25	3.15	No	No	Yes	Yes	7	0
210	3x37	4x56	Shared	3.99	2.66	Yes	No	No	No	6	5
211	3x37	5x461	Shared	14.64	5.985	Yes	No	No	No	6	6
212	3x38	4x50	Shared	17.16	12.26	No	Yes	Yes	Yes	7	9
213	3x38	4x53	Shared	4.85	4.04	No	Yes	Yes	No	7	8
214	3x40	5x50	Shared	3.5	3.5	No	No	No	No	8	9
215	3x41	4x49	Shared	3.25	1.62	No	No	No	No	5	7
216	3x43	6x44	Shared	6.09	3.045	No	No	Yes	Yes	8	9
217	3x44	5x50	Shared	5.25	2.625	No	No	No	No	7	9
218	3x44	5x53	Shared	3.04	3.04	No	No	No	No	7	6
219	3x45	4x45	Shared	3.07	3.07	No	No	No	No	7	5
220	3x47	5x54	Shared	4.87	3.25	No	No	No	No	9	8
221	3x47	5x57	Shared	3.42	2.565	No	No	No	No	9	7
222	3x47	5x58	Shared	5.34	4	No	No	No	Yes	9	9
223	3x49	3x53	Shared	4.67	1.56	No	No	No	No	8	8
224	3x51	3x55	Shared	5.05	5.68	Yes	Yes	No	No	8	7
225	3x51	5x60	Shared	16.46	6.17	Yes	Yes	No	No	8	4
226	3x55	3x56	Shared	3.79	5.05	No	No	Yes	No	7	7
227	4x38	4x41	Shared	3.1	0.775	No	No	No	No	6	5
228	4x59	4x60	Shared	5.34	5.34	No	No	No	No	4	8
229	4x61	5x39	Shared	4.69	5.275	No	No	Yes	Yes	5	6
230	4x64	E2.W207	Shared	26.06	9.02	Yes	Yes	No	Yes	5	5
231	4x64	E2.P208	Shared	5.78	6.5	Yes	Yes	Yes	No	5	4
232	4x65	E2x52	Shared	5.82	6.4	Yes	Yes	No	No	6	4
233	E2.E188	E2x51	Shared	5.64	6.35	No	Yes	No	No	4	4
234	E2.E188	E2.K206	Shared	9.45	8.1	No	Yes	No	No	4	3
235	E2.V201	E2.Y189	Shared	6.31	6.94	No	No	Yes	Yes	4	5
236	E2.I195	E2.P196	Shared	3.39	5.08	No	No	No	No	2	3
237	E2.P208	E2.W207	Shared	5.4	3.375	Yes	No	No	Yes	4	5
238	5x36	E2.W207	Shared	12.67	6.33	No	No	No	Yes	4	5
239	5x34	5x35	Shared	3.63	1.815	No	No	No	No	1	3
240	5x39	Lig	Shared	3.6	10.25	Yes	Yes	Yes	Yes	6	0
241	5x40	6x59	Shared	7.36	5.89	No	No	No	No	4	5
242	5x40	Lig	Shared	4.62	4.61	No	No	Yes	Yes	4	0
243	5x44	6x52	Shared	6.43	1.93	Yes	No	Yes	No	5	7
244	5x45	5x48	Shared	2.98	2.235	No	No	No	No	5	4
245	5x47	5x51	Shared	8.21	3.52	No	No	No	Yes	8	5
246	5x49	5x50	Shared	4.93	4.105	No	No	No	No	6	9
247	5x51	6x45	Shared	4.73	1.58	No	Yes	No	No	5	5
248	5x56	5x60	Shared	11.76	3.745	No	No	No	No	4	4
249	5x58	6x37	Shared	4.69	5.275	No	Yes	Yes	No	9	8
250	5x62	5x63	Shared	3.71	3.09	No	No	No	No	5	4
251	5x65	6x30	Shared	3.64	2.43	No	Yes	Yes	Yes	8	7
252	5x66	5x67	Shared	4.2	2.8	No	No	No	No	6	4
253	6x25	6x29	Shared	5.64	8.465	No	No	No	No	4	5
254	6x28	6x32	Shared	6.78	0.68	No	No	No	No	4	8
255	6x40	7x52	Shared	4.47	3.725	No	No	No	Yes	8	8
256	6x40	7x53	Shared	3.79	6.94	No	No	Yes	Yes	8	9
257	6x44	6x48	Shared	14.03	5.51	Yes	Yes	Yes	Yes	9	8
258	6x48	6x52	Shared	10.58	3.7	Yes	Yes	Yes	No	8	7
259	6x48	7x41	Shared	7.78	3.89	Yes	Yes	No	No	8	7
260	6x48	7x45	Shared	4.94	1.855	Yes	Yes	No	No	8	9
261	6x49	6x50	Shared	3.28	3.28	No	No	No	No	5	9
262	6x50	7x37	Shared	10.11	7.225	No	No	Yes	No	9	6
263	6x54	7x30	Shared	9.28	6.19	Yes	Yes	Yes	No	4	4
264	6x54	7x33	Shared	6.28	4.395	Yes	Yes	No	No	4	5
265	6x54	7x37	Shared	6.43	7.5	Yes	Yes	Yes	No	4	6
266	6x55	Lig	Shared	12.28	8.175	No	No	Yes	Yes	5	0
267	6x58	E3.V297	Shared	3.21	3.21	No	No	No	No	4	6
268	6x61	E3.Q296	Shared	5.22	7.83	No	No	No	No	2	5
269	7x33	7x37	Shared	5.02	3.77	No	No	Yes	No	5	6
270	7x34	Lig	Shared	8.24	6.67	No	No	Yes	Yes	4	0
271	7x38	7x42	Shared	13.13	9.195	Yes	Yes	No	No	5	7
272	7x38	Lig	Shared	9.49	7.61	Yes	Yes	Yes	Yes	5	0
273	7x43	7x47	Shared	6.98	6.285	No	No	Yes	No	5	7
274	7x55	7x56	Shared	8.14	2.325	No	No	No	No	6	7
275	8x47	8x50	Shared	11.63	7.56	No	No	Yes	Yes	8	8
276	8x50	8x54	Shared	5.16	2.575	Yes	Yes	No	Yes	8	6
277	4x41	I2.I160	Shared	2.94	0.735	No	No	No	No	5	5
278	4x41	4x45	Shared	2.94	0.735	No	No	No	No	5	5
279	4x60	4x64	Shared	2.89	2.89	No	No	Yes	Yes	8	5
280	3x48	5x53	Shared	2.85	3.565	No	No	No	No	6	6
281	4x52	4x56	Shared	2.85	1.425	No	No	No	No	4	5
282	4x44	4x48	Shared	2.77	6.23	No	No	No	No	3	3
283	3x30	4x57	Shared	2.67	2.67	No	No	No	No	6	7
284	1x59	1x60	Shared	2.48	6.82	No	No	Yes	No	5	5
285	5x62	5x66	Shared	2.32	6.96	No	No	No	No	5	6
286	1x48	1x49	Shared	1.76	2.645	No	No	No	No	4	8
287	2x66	2x67	Shared	1.75	0.875	No	No	No	No	4	5
288	2x53	3x35	Shared	1.7	1.7	No	No	No	No	7	7
289	6x43	7x48	Shared	1.7	0.85	No	No	No	No	6	6
290	1x38	7x39	Shared	1.62	0.81	No	No	No	No	5	5
291	6x38	6x42	Shared	1.6	1.6	No	No	No	No	6	4
292	6x42	6x46	Shared	1.6	0.8	No	No	No	No	4	6
293	1x47	1x48	Shared	1.54	1.54	No	No	No	No	6	4
294	3x23	3x24	Shared	1.49	1.49	No	No	No	No	2	6
295	1x54	1x58	Shared	1.47	2.205	No	No	No	No	7	3
296	E2.E188	E2.S190	Shared	1.44	6.465	No	Yes	No	No	4	1
297	5x46	5x461	Shared	1.43	1.425	No	No	No	No	4	6
298	5x41	6x56	Shared	1.38	4.155	No	No	No	No	4	5
299	7x28	7x29	Shared	1.35	3.375	No	No	No	No	3	3
300	2x63	E2.A202	Shared	1.33	2.665	No	No	No	No	5	4
301	4x63	4x64	Shared	1.26	8.165	No	No	Yes	Yes	4	5
302	Lig	Lig	npy2_on	0	84.19	Yes	Yes	Yes	Yes	0	0
303	E2.E188	Lig	npy2_on	0	5.05	No	Yes	Yes	Yes	4	0
304	E2.I192	Lig	npy2_on	0	4.84	No	No	Yes	Yes	2	0
305	E2.E193	Lig	npy2_on	0	3.375	No	No	Yes	Yes	2	0
306	Lig	NT.L40	npy2_on	0	7.46	Yes	Yes	No	No	0	0
307	E2.I194	Lig	npy2_on	0	10.975	No	No	Yes	Yes	1	0
308	7x28	Lig	npy2_on	0	6.805	No	No	Yes	Yes	3	0
309	E3.S295	Lig	npy2_on	0	2.785	No	No	Yes	Yes	1	0
310	E3.L298	Lig	npy2_on	0	16.46	No	No	Yes	Yes	1	0
311	7x26	Lig	npy2_on	0	4.41	No	No	Yes	Yes	1	0
312	7x31	Lig	npy2_on	0	6.58	No	No	Yes	Yes	4	0
313	7x30	Lig	npy2_on	0	13.425	Yes	No	Yes	Yes	4	0
314	E2x52	Lig	npy2_on	0	12.21	No	No	Yes	Yes	4	0
315	6x58	Lig	npy2_on	0	5.885	No	No	Yes	Yes	4	0
316	6x59	Lig	npy2_on	0	4.17	No	No	Yes	Yes	5	0
317	2x64	Lig	npy2_on	0	4.25	No	No	Yes	Yes	4	0
318	2x56	Lig	npy2_on	0	2.68	Yes	No	Yes	Yes	6	0
319	7x29	NT.S43	npy2_on	0	9.34	No	No	No	No	3	0
320	1x35	7x35	npy2_on	0	2.95	No	No	No	No	5	3
321	1x39	2x57	npy2_on	0	5.275	Yes	Yes	No	Yes	7	7
322	1x39	7x35	npy2_on	0	3.745	Yes	Yes	No	No	7	3
323	1x42	2x57	npy2_on	0	2.85	No	No	No	Yes	7	7
324	1x43	2x54	npy2_on	0	2.835	Yes	No	No	Yes	6	6
325	1x50	2x51	npy2_on	0	4.12	No	No	No	No	9	7
326	1x53	8x50	npy2_on	0	4.42	No	No	Yes	Yes	9	8
327	1x56	8x50	npy2_on	0	2.52	No	No	Yes	Yes	7	8
328	1x56	8x54	npy2_on	0	6.55	No	No	No	Yes	7	6
329	1x57	8x50	npy2_on	0	3.79	No	No	Yes	Yes	7	8
330	1x59	8x57	npy2_on	0	2.41	No	No	No	No	5	4
331	2x40	I1x50	npy2_on	0	4.91	No	Yes	Yes	Yes	8	8
332	2x41	I1x51	npy2_on	0	4.28	No	No	No	No	5	6
333	2x38	I2.I160	npy2_on	0	3.07	No	Yes	No	No	6	5
334	2x39	2x40	npy2_on	0	2.92	No	No	No	Yes	8	8
335	2x39	3x49	npy2_on	0	4.34	No	No	No	No	8	8
336	2x41	4x39	npy2_on	0	4.96	No	No	No	No	5	1
337	2x42	3x49	npy2_on	0	5.97	Yes	Yes	No	No	7	8
338	2x42	4x42	npy2_on	0	2.64	Yes	Yes	No	No	7	7
339	2x46	2x50	npy2_on	0	5.43	No	Yes	No	Yes	9	9
340	2x46	7x49	npy2_on	0	6.18	No	Yes	No	No	9	9
341	2x46	7x53	npy2_on	0	2.93	No	Yes	Yes	Yes	9	9
342	2x48	4x50	npy2_on	0	2.45	No	No	Yes	Yes	6	9
343	2x49	3x38	npy2_on	0	2.545	No	No	No	Yes	8	7
344	2x50	3x39	npy2_on	0	5.155	No	Yes	No	No	9	9
345	2x50	7x49	npy2_on	0	6.73	No	Yes	No	No	9	9
346	2x53	7x46	npy2_on	0	3.17	No	No	No	No	7	9
347	2x54	2x57	npy2_on	0	3.435	No	Yes	No	Yes	6	7
348	2x551	3x31	npy2_on	0	2.365	No	No	No	No	5	5
349	2x57	2x58	npy2_on	0	2.46	No	Yes	No	No	7	8
350	2x59	3x28	npy2_on	0	9.835	No	No	No	Yes	5	5
351	2x60	3x32	npy2_on	0	2.835	No	No	No	Yes	6	6
352	2x60	7x38	npy2_on	0	10.265	No	No	Yes	Yes	6	5
353	2x62	2x66	npy2_on	0	3.01	No	No	No	No	4	4
354	E1x49	E1x51	npy2_on	0	14.175	No	No	No	No	5	3
355	3x28	E1x50	npy2_on	0	5.515	No	Yes	Yes	Yes	5	8
356	E1x50	E2x50	npy2_on	0	3.265	Yes	Yes	No	No	8	9
357	3x24	3x28	npy2_on	0	2.98	No	No	No	Yes	6	5
358	3x25	4x65	npy2_on	0	2.79	No	Yes	Yes	Yes	9	6
359	3x28	3x32	npy2_on	0	4.3	No	Yes	No	Yes	5	6
360	3x40	6x44	npy2_on	0	2.59	No	No	Yes	Yes	8	9
361	3x43	7x53	npy2_on	0	4.69	No	No	Yes	Yes	8	9
362	3x46	3x50	npy2_on	0	5.635	No	No	No	No	9	9
363	3x46	7x53	npy2_on	0	4.84	No	No	Yes	Yes	9	9
364	3x50	5x58	npy2_on	0	4.63	No	No	No	Yes	9	9
365	3x50	7x53	npy2_on	0	4.115	No	No	Yes	Yes	9	9
366	3x51	3x56	npy2_on	0	7.445	Yes	Yes	Yes	No	8	7
367	3x51	5x56	npy2_on	0	3.61	Yes	Yes	No	No	8	4
368	3x51	5x57	npy2_on	0	5.09	Yes	Yes	No	No	8	7
369	3x52	I2.I160	npy2_on	0	6.265	Yes	No	No	No	4	5
370	3x53	I2.K159	npy2_on	0	2.425	No	No	No	No	8	5
371	I2.H155	I2.L156	npy2_on	0	5.785	No	No	No	No	8	5
372	5x64	I2.H155	npy2_on	0	5.24	No	No	No	No	5	8
373	4x46	4x50	npy2_on	0	2.35	No	Yes	Yes	Yes	7	9
374	E2.I192	E2.S190	npy2_on	0	3.87	No	No	No	No	2	1
375	E2.F198	E2.I194	npy2_on	0	3.14	No	No	No	No	1	1
376	E2.F198	E2.I195	npy2_on	0	8.79	No	No	No	No	1	2
377	E2.F198	E2.I200	npy2_on	0	3.14	No	No	No	No	1	3
378	E2.W207	E2x52	npy2_on	0	2.725	No	Yes	No	No	5	4
379	5x39	E2.W207	npy2_on	0	2.41	Yes	Yes	No	Yes	6	5
380	5x33	E2.G209	npy2_on	0	2.785	No	No	No	No	2	4
381	5x33	5x35	npy2_on	0	3.18	No	No	No	No	2	3
382	5x37	6x59	npy2_on	0	4.335	No	No	No	No	3	5
383	5x43	5x461	npy2_on	0	3	No	No	No	No	5	6
384	5x43	6x52	npy2_on	0	2.79	No	No	Yes	No	5	7
385	5x47	6x49	npy2_on	0	11.72	No	No	No	No	8	5
386	5x49	5x53	npy2_on	0	2.85	No	No	No	No	6	6
387	5x51	6x44	npy2_on	0	3.045	No	Yes	Yes	Yes	5	9
388	5x57	5x58	npy2_on	0	3.815	No	No	No	Yes	7	9
389	5x58	5x61	npy2_on	0	2.42	No	Yes	No	No	9	8
390	5x58	6x40	npy2_on	0	3.79	No	Yes	No	No	9	8
391	5x58	6x41	npy2_on	0	2.52	No	Yes	No	No	9	8
392	5x62	6x34	npy2_on	0	5.455	No	No	No	No	5	6
393	5x65	6x26	npy2_on	0	3.52	No	Yes	No	Yes	8	4
394	5x66	6x30	npy2_on	0	8.045	No	No	Yes	Yes	6	7
395	5x68	6x26	npy2_on	0	8.71	No	No	No	Yes	6	4
396	5x69	6x23	npy2_on	0	3.695	No	No	No	Yes	4	0
397	5x70	5x71	npy2_on	0	3.56	No	Yes	No	No	0	0
398	5x70	6x23	npy2_on	0	2.98	No	Yes	No	Yes	0	0
399	5x70	6x26	npy2_on	0	3.82	No	Yes	No	Yes	0	4
400	6x23	6x27	npy2_on	0	3.83	No	Yes	No	No	0	4
401	6x24	6x28	npy2_on	0	9.135	No	No	No	No	4	4
402	6x26	6x27	npy2_on	0	9.8	No	Yes	No	No	4	4
403	6x26	6x30	npy2_on	0	4.115	No	Yes	Yes	Yes	4	7
404	6x27	6x30	npy2_on	0	6.77	No	No	Yes	Yes	4	7
405	6x30	6x31	npy2_on	0	4.085	Yes	Yes	No	No	7	5
406	6x36	7x56	npy2_on	0	6.5	No	No	No	No	8	7
407	6x39	7x52	npy2_on	0	2.38	No	No	No	Yes	6	8
408	6x47	7x45	npy2_on	0	3.44	No	No	No	No	8	9
409	6x51	7x41	npy2_on	0	3.15	No	No	No	No	6	7
410	6x54	E3.V297	npy2_on	0	2.62	Yes	Yes	No	No	4	6
411	6x55	7x34	npy2_on	0	2.34	No	No	No	No	5	4
412	6x58	E3.L298	npy2_on	0	2.98	No	No	No	No	4	1
413	6x60	6x61	npy2_on	0	3.5	No	No	No	No	4	2
414	7x30	E3.L298	npy2_on	0	4.69	Yes	No	No	No	4	1
415	7x29	7x32	npy2_on	0	6.63	No	No	No	No	3	1
416	7x55	8x51	npy2_on	0	8.5	No	No	No	No	6	8
417	7x55	8x54	npy2_on	0	8.02	No	No	No	Yes	6	6
418	8x48	8x49	npy2_on	0	3.725	No	No	No	No	5	6
419	8x55	8x59	npy2_on	0	4.25	No	No	No	No	4	3
420	1x28	1x30	npy2_on	0	5.3	No	No	No	No	0	2
421	E2.I192	E2.I200	npy2_on	0	2.945	No	No	No	No	2	3
422	E2.E193	E2.E199	npy2_on	0	10.15	No	No	No	No	2	4
423	3x55	5x64	npy2_on	0	2.275	No	No	No	No	7	5
424	5x51	5x55	npy2_on	0	2.25	No	Yes	No	No	5	5
425	3x56	I2.E157	npy2_on	0	2.245	Yes	No	No	No	7	4
426	6x43	7x52	npy2_on	0	2.235	No	No	No	Yes	6	8
427	1x28	1x31	npy2_on	0	2.235	No	No	No	No	0	4
428	1x27	NT.I41	npy2_on	0	2.18	No	No	No	No	0	0
429	7x54	8x50	npy2_on	0	2.175	No	No	Yes	Yes	7	8
430	5x61	5x65	npy2_on	0	2.14	No	No	No	Yes	8	8
431	5x44	5x45	npy2_on	0	2.075	Yes	No	No	No	5	5
432	8x47	8x49	npy2_on	0	2.045	No	No	No	No	8	6
433	E2.Y189	E2x50	npy2_on	0	2.015	Yes	Yes	No	No	5	9
434	E2.E199	E2.L191	npy2_on	0	1.99	No	No	No	No	4	3
435	7x26	E3.Q296	npy2_on	0	1.96	No	No	No	No	1	5
436	7x46	7x47	npy2_on	0	1.945	No	No	Yes	No	9	7
437	2x551	2x59	npy2_on	0	1.83	No	No	No	No	5	5
438	4x46	4x47	npy2_on	0	1.76	No	Yes	No	No	7	4
439	2x52	3x35	npy2_on	0	1.58	No	No	No	No	7	7
440	3x34	4x54	npy2_on	0	1.58	No	No	No	No	5	4
441	3x34	4x57	npy2_on	0	1.58	No	No	No	No	5	7
442	E2.E211	Lig	npy2_on	0	1.57	No	No	Yes	Yes	2	0
443	1x41	1x42	npy2_on	0	1.55	No	No	No	No	5	7
444	5x34	5x37	npy2_on	0	1.52	No	No	No	No	1	3
445	1x51	1x52	npy2_on	0	1.5	No	No	No	No	4	7
446	5x37	E2.K212	npy2_on	0	1.5	No	No	No	No	3	3
447	2x55	2x551	npy2_on	0	1.475	No	No	No	No	5	5
448	3x54	5x61	npy2_on	0	1.47	No	No	No	No	8	8
449	5x65	6x33	npy2_on	0	1.47	No	Yes	No	No	8	8
450	6x56	6x60	npy2_on	0	1.43	No	No	No	No	5	4
451	7x31	NT.D42	npy2_on	0	1.385	No	No	No	No	4	0
452	7x51	7x52	npy2_on	0	1.385	No	No	No	Yes	7	8
453	7x26	7x27	npy2_on	0	1.355	No	No	No	No	1	1
454	4x38	4x40	npy2_on	0	1.32	No	No	No	No	6	5
455	E2.E210	E2.E211	npy2_on	0	1.27	No	No	No	No	1	2
456	5x35	5x38	npy2_on	0	1.26	No	No	No	No	3	4
457	5x71	5x72	npy2_on	0	1.015	No	No	No	No	0	0
458	4x51	4x54	npy2_on	0	0.975	No	No	No	No	4	4
459	5x70	I3.A255	npy2_on	0	0.855	No	Yes	No	No	0	0
460	6x45	6x46	npy2_on	0	0.85	No	No	No	No	5	6
461	3x38	4x49	npy2_on	0	0.85	No	Yes	No	No	7	7
462	6x57	E3.V297	npy2_on	0	0.85	No	No	No	No	5	6
463	1x36	1x40	npy2_on	0	0.82	No	No	No	No	6	4
464	E2.D197	E2.P196	npy2_on	0	0.805	No	No	No	No	4	3
465	1x33	1x34	npy2_on	0	0.8	No	No	No	No	6	5
466	7x35	7x36	npy2_on	0	0.795	No	No	No	No	3	6
467	4x54	4x55	npy2_on	0	0.79	No	No	No	No	4	4
468	1x29	1x33	npy2_on	0	0.77	No	No	No	No	0	6
469	7x31	NT.T44	npy2_on	0	0.75	No	No	No	No	4	0
470	1x33	1x37	npy2_on	0	0.745	No	No	No	No	6	6
471	1x28	1x29	npy2_on	0	0.715	No	No	No	No	0	0
472	6x23	6x24	npy2_on	0	0.675	No	Yes	No	No	0	4
473	3x52	I2.S158	npy2_on	0	0.66	Yes	No	No	No	4	5
474	5x59	5x60	npy2_on	0	0.645	No	No	No	No	3	4
475	5x39	5x42	npy2_on	0	0.635	Yes	Yes	No	No	6	3

Orange: nodes, hubs and links specific of npy2_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of npy2_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	npy2_off Avg Int. Strength	npy2_on Avg Int. Strength	npy2_off Num Of Links	npy2_on Num Of Links	ConSurf
1	1x43	npy2_off	2.7125	4.63	4	2	6
2	1x60	npy2_off	4.165	3.775	4	3	5
3	2x56	npy2_off	4.4525	5.14333	4	3	6
4	2x65	npy2_off	5.5775	5.22667	4	3	4
5	E1x52	npy2_off	6.476	6.75667	5	3	7
6	3x37	npy2_off	6.5575	4.3225	4	2	6
7	3x52	npy2_off	7.52	3.4625	4	2	4
8	3x56	npy2_off	5.7525	4.91333	4	3	7
9	4x53	npy2_off	3.8075	3.52	4	2	8
10	E2.P208	npy2_off	5.7375	4.9375	4	2	4
11	5x44	npy2_off	3.685	2.0025	4	2	5
12	6x37	npy2_off	4.195	5.275	4	1	8
13	6x52	npy2_off	8.812	2.80667	5	3	7
14	7x30	npy2_off	6.225	8.10167	4	3	4
15	7x37	npy2_off	5.7175	6.165	4	3	6
16	7x47	npy2_off	7	3.555	4	3	7
17	1x39	Shared	6.715	7.009	4	5	7
18	I1x50	Shared	4.5275	3.79375	4	4	8
19	2x42	Shared	4.8025	4.824	4	5	7
20	E1x50	Shared	6.486	6.878	5	5	8
21	3x51	Shared	7.8725	5.599	4	5	8
22	4x50	Shared	7.126	5.96	5	4	9
23	4x64	Shared	8.9975	6.64375	4	4	5
24	4x65	Shared	6.916	5.2825	5	4	6
25	E2.Y189	Shared	8.07	5.17625	4	4	5
26	5x39	Shared	7.805	4.6425	4	4	6
27	6x30	Shared	8.0175	5.089	4	5	7
28	6x44	Shared	7.01	3.5475	4	4	9
29	6x48	Shared	8.692	3.726	5	5	8
30	6x54	Shared	8.258	5.17625	5	4	4
31	7x38	Shared	9.995	8.6725	4	4	5
32	7x53	Shared	6.80167	4.3225	6	6	9
33	8x50	Shared	8.09833	4.80833	6	9	8
34	Lig	Shared	6.51944	12.6771	18	29	0
35	2x38	npy2_on	3.94	3.81	3	4	6
36	2x40	npy2_on	8.28333	4.83625	3	4	8
37	2x46	npy2_on	4.81333	5.11	3	4	9
38	2x50	npy2_on	6.31	5.17	2	4	9
39	2x54	npy2_on	6.815	5.705	2	4	6
40	2x57	npy2_on	6.38	4.82167	2	6	7
41	3x25	npy2_on	5.51	3.8375	3	4	9
42	3x28	npy2_on	3.475	5.232	2	5	5
43	3x32	npy2_on	9.75667	5.3775	3	4	6
44	3x38	npy2_on	11.005	4.92375	2	4	7
45	4x46	npy2_on	10.3	4.23	2	4	7
46	E2.E188	npy2_on	5.51	6.49125	3	4	4
47	E2.W207	npy2_on	14.71	4.772	3	5	5
48	5x51	npy2_on	6.47	2.59875	2	4	5
49	5x58	npy2_on	6.28667	3.77857	3	7	9
50	5x65	npy2_on	3.08333	2.39	3	4	8
51	5x70	npy2_on	0	2.80375	0	4	0
52	6x23	npy2_on	0	2.795	0	4	0
53	6x26	npy2_on	4.865	5.993	2	5	4
54	7x52	npy2_on	4.355	2.43125	2	4	8
55	8x54	npy2_on	5.97	4.89625	3	4	6

Orange: nodes, hubs and links specific of npy2_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of npy2_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	npy2_off Recurrence	npy2_on Recurrence	npy2_off Hub1?	npy2_on Hub1?	npy2_off Hub2?	npy2_on Hub2?	ConSurf1	ConSurf2
1	7x35	Lig	npy2_off	11.9339	0	No	No	Yes	Yes	3	0
2	2x60	Lig	npy2_off	17.7144	0.814788	No	No	Yes	Yes	6	0
3	1x39	2x60	npy2_off	16.1361	0	Yes	Yes	No	No	7	6
4	1x39	2x61	npy2_off	22.1031	5.12604	Yes	Yes	No	No	7	6
5	2x61	2x65	npy2_off	17.7078	4.11085	No	No	Yes	No	6	4
6	7x38	7x42	npy2_off	66.2427	7.48602	Yes	Yes	No	No	5	7
7	1x42	7x42	npy2_off	12.3468	0	No	No	No	No	7	7
8	2x57	7x42	npy2_off	56.6529	6.57367	No	Yes	No	No	7	7
9	1x43	2x57	npy2_off	55.1412	1.93545	Yes	No	No	Yes	6	7
10	1x43	1x47	npy2_off	49.2275	0	Yes	No	No	No	6	6
11	1x47	1x48	npy2_off	48.2152	1.02574	No	No	No	No	6	4
12	1x48	1x49	npy2_off	48.162	3.06666	No	No	No	No	4	8
13	1x49	7x50	npy2_off	48.2352	4.07921	No	No	No	No	8	9
14	1x50	7x50	npy2_off	15.65	5.08649	No	No	No	No	9	9
15	1x50	2x50	npy2_off	14.3514	7.08522	No	No	No	Yes	9	9
16	2x50	7x46	npy2_off	10.7818	0	No	Yes	No	No	9	9
17	1x50	2x47	npy2_off	10.4555	0	No	No	No	No	9	9
18	1x53	7x50	npy2_off	45.305	0	No	No	No	No	9	9
19	1x53	2x47	npy2_off	15.8897	1.06793	No	No	No	No	9	9
20	1x53	7x53	npy2_off	53.1233	0	No	No	Yes	Yes	9	9
21	7x53	8x50	npy2_off	37.5133	0	Yes	Yes	Yes	Yes	9	8
22	1x54	2x47	npy2_off	10.4422	0	No	No	No	No	7	9
23	8x50	I1x50	npy2_off	23.8879	6.29153	Yes	Yes	Yes	Yes	8	8
24	1x60	I1x50	npy2_off	14.0583	5.0944	Yes	No	Yes	Yes	5	8
25	3x37	Lig	npy2_off	83.5842	0	Yes	No	Yes	Yes	6	0
26	3x37	4x53	npy2_off	77.0511	0	Yes	No	Yes	No	6	8
27	3x34	4x53	npy2_off	38.7986	7.41747	No	No	Yes	No	5	8
28	3x34	4x50	npy2_off	38.5922	0	No	No	Yes	Yes	5	9
29	2x38	4x39	npy2_off	12.1337	5.06012	No	Yes	No	No	6	1
30	3x38	4x53	npy2_off	38.7986	8.45639	No	Yes	Yes	No	7	8
31	2x42	3x45	npy2_off	42.7078	4.95992	Yes	Yes	No	No	7	7
32	6x52	Lig	npy2_off	53.4563	0	Yes	No	Yes	Yes	7	0
33	3x32	Lig	npy2_off	11.9539	7.77608	No	Yes	Yes	Yes	6	0
34	2x56	3x32	npy2_off	12.4534	0.912351	Yes	No	No	Yes	6	6
35	4x65	Lig	npy2_off	14.0184	0	Yes	Yes	Yes	Yes	6	0
36	E1x50	Lig	npy2_off	57.1657	0	Yes	Yes	Yes	Yes	8	0
37	E1x50	E1x52	npy2_off	21.9033	1.39226	Yes	Yes	Yes	No	8	7
38	E1x50	E2.Y189	npy2_off	33.1846	0	Yes	Yes	Yes	Yes	8	5
39	3x33	Lig	npy2_off	12.7464	1.0231	No	No	Yes	Yes	4	0
40	3x33	4x57	npy2_off	10.2224	0	No	No	No	No	4	7
41	3x37	4x56	npy2_off	10.329	2.04356	Yes	No	No	No	6	5
42	3x37	5x461	npy2_off	10.329	3.05875	Yes	No	No	No	6	6
43	3x43	6x41	npy2_off	93.4936	0	No	No	No	No	8	8
44	5x54	6x41	npy2_off	73.728	0	No	No	No	No	8	8
45	3x44	5x54	npy2_off	17.7744	0	No	No	No	No	7	8
46	3x45	4x45	npy2_off	39.8575	3.96846	No	No	No	No	7	5
47	3x47	5x54	npy2_off	65.2437	1.64012	No	No	No	No	9	8
48	3x47	5x58	npy2_off	34.9161	3.2196	No	No	No	Yes	9	9
49	5x58	6x37	npy2_off	47.0964	1.64012	No	Yes	Yes	No	9	8
50	6x41	6x42	npy2_off	20.1985	0	No	No	No	No	8	4
51	6x38	6x42	npy2_off	17.3082	1.02837	No	No	No	No	6	4
52	5x58	6x38	npy2_off	16.2693	0	No	Yes	No	No	9	6
53	3x47	5x57	npy2_off	60.7485	0.0553739	No	No	No	No	9	7
54	4x41	4x45	npy2_off	37.1204	2.99546	No	No	No	No	5	5
55	4x41	I2.I160	npy2_off	31.6329	3.05875	No	No	No	No	5	5
56	3x49	I2.I160	npy2_off	28.8825	0	No	No	No	No	8	5
57	3x49	3x53	npy2_off	26.1321	2.04883	No	No	No	No	8	8
58	5x56	5x57	npy2_off	58.078	0	No	No	No	No	4	7
59	5x56	5x60	npy2_off	55.4076	0.00263685	No	No	No	No	4	4
60	3x51	5x60	npy2_off	52.7504	3.27233	Yes	Yes	No	No	8	4
61	3x51	3x52	npy2_off	12.167	0	Yes	Yes	Yes	No	8	4
62	3x51	5x61	npy2_off	31.1201	0	Yes	Yes	No	No	8	8
63	3x53	6x30	npy2_off	23.4816	0	No	No	Yes	Yes	8	7
64	6x30	I2.E157	npy2_off	14.6644	0	Yes	Yes	No	No	7	4
65	6x26	I2.E157	npy2_off	11.7075	0	No	Yes	No	No	4	4
66	5x39	Lig	npy2_off	31.26	9.09714	Yes	Yes	Yes	Yes	6	0
67	4x60	5x39	npy2_off	29.3287	0	No	No	Yes	Yes	8	6
68	4x60	4x64	npy2_off	24.8002	3.73115	No	No	Yes	Yes	8	5
69	E2.L191	E2.V201	npy2_off	12.9129	0	No	No	No	No	3	4
70	E2.L191	E2.S190	npy2_off	10.3556	0	No	No	No	No	3	1
71	4x64	E2.P208	npy2_off	14.8109	0.00791056	Yes	Yes	Yes	No	5	4
72	5x61	6x34	npy2_off	28.3564	0	No	No	No	No	8	6
73	6x34	6x35	npy2_off	14.6311	0	No	No	No	No	6	6
74	5x62	6x35	npy2_off	11.7275	0	No	No	No	No	5	6
75	5x65	6x34	npy2_off	14.4113	0	No	Yes	No	No	8	6
76	6x40	7x52	npy2_off	10.2224	4.44046	No	No	No	Yes	8	8
77	7x34	Lig	npy2_off	60.7152	0.930809	No	No	Yes	Yes	4	0
78	6x54	7x34	npy2_off	57.805	0	Yes	Yes	No	No	4	4
79	6x54	7x37	npy2_off	20.1718	1.38698	Yes	Yes	Yes	No	4	6
80	6x50	7x37	npy2_off	15.2571	2.0251	No	No	Yes	No	9	6
81	6x50	7x40	npy2_off	10.2224	0	No	No	No	No	9	7
82	6x54	6x58	npy2_off	10.0027	0	Yes	Yes	No	No	4	4
83	6x54	7x30	npy2_off	24.9267	3.27497	Yes	Yes	Yes	No	4	4
84	6x61	E3.V297	npy2_off	10.0759	0	No	No	No	No	2	6
85	2x42	3x46	npy2_off	35.9017	0	Yes	Yes	No	No	7	9
86	3x46	6x37	npy2_off	34.8162	0	No	No	Yes	No	9	8
87	6x33	6x37	npy2_off	59.2302	0	No	No	Yes	No	8	8
88	6x36	7x53	npy2_off	17.4547	0	No	No	Yes	Yes	8	9
89	6x33	8x47	npy2_off	56.6462	0	No	No	No	No	8	8
90	6x36	8x47	npy2_off	17.4614	0	No	No	No	No	8	8
91	8x47	8x50	npy2_off	36.4678	3.19323	No	No	Yes	Yes	8	8
92	7x38	Lig	Shared	76.7048	31.0648	Yes	Yes	Yes	Yes	5	0
93	1x39	7x38	Shared	19.9188	23.6236	Yes	Yes	Yes	Yes	7	5
94	2x45	4x50	Shared	72.9688	14.384	No	No	Yes	Yes	9	9
95	2x45	4x46	Shared	71.6436	17.9069	No	No	No	Yes	9	7
96	2x42	4x46	Shared	70.285	18.5766	Yes	Yes	No	Yes	7	7
97	2x38	2x42	Shared	24.1875	11.7815	No	Yes	Yes	Yes	6	7
98	3x38	4x50	Shared	38.5922	12.5593	No	Yes	Yes	Yes	7	9
99	3x36	Lig	Shared	49.2874	95.5279	No	No	Yes	Yes	7	0
100	3x36	6x48	Shared	48.8146	95.6835	No	No	Yes	Yes	7	8
101	6x44	6x48	Shared	100	97.4633	Yes	Yes	Yes	Yes	9	8
102	2x46	3x42	Shared	10.269	33.8836	No	Yes	No	No	9	8
103	6x48	6x52	Shared	55.5208	10.0174	Yes	Yes	Yes	No	8	7
104	3x43	6x44	Shared	94.5525	100	No	No	Yes	Yes	8	9
105	E2.V201	E2.Y189	Shared	26.858	16.831	No	No	Yes	Yes	4	5
106	E1x49	E2.V201	Shared	11.7941	14.0386	No	No	No	No	5	4
107	6x40	7x53	Shared	12.6598	41.4909	No	No	Yes	Yes	8	9
108	1x39	7x35	npy2_on	0	10.1229	Yes	Yes	No	No	7	3
109	2x46	7x53	npy2_on	0	42.4692	No	Yes	Yes	Yes	9	9
110	3x43	7x53	npy2_on	0	99.9789	No	No	Yes	Yes	8	9
111	2x43	8x50	npy2_on	0.925679	26.8933	No	No	Yes	Yes	8	8
112	2x43	7x53	npy2_on	1.08551	27.6632	No	No	Yes	Yes	8	9
113	2x45	3x42	npy2_on	9.06367	33.0767	No	No	No	No	9	8
114	2x63	E1x50	npy2_on	0.512786	19.3624	No	No	Yes	Yes	5	8
115	2x63	Lig	npy2_on	6.4398	20.8311	No	No	Yes	Yes	5	0
116	E1x49	E1x51	npy2_on	0	11.2409	No	No	No	No	5	3
117	3x25	E2.Y189	npy2_on	0.625999	16.657	No	Yes	Yes	Yes	9	5
118	4x65	E2x52	npy2_on	2.6838	11.8368	Yes	Yes	No	No	6	4
119	E2x52	Lig	npy2_on	0	18.2971	No	No	Yes	Yes	4	0
120	3x50	7x53	npy2_on	0	37.7307	No	No	Yes	Yes	9	9
121	3x50	5x58	npy2_on	0	37.2877	No	No	No	Yes	9	9
122	5x58	6x40	npy2_on	0	37.7676	No	Yes	No	No	9	8
123	5x57	5x58	npy2_on	0	17.6089	No	No	No	Yes	7	9
124	3x51	5x57	npy2_on	0	16.0769	Yes	Yes	No	No	8	7
125	5x58	5x61	npy2_on	0	52.4628	No	Yes	No	No	9	8
126	5x65	6x30	npy2_on	5.72722	20.1113	No	Yes	Yes	Yes	8	7
127	5x61	5x65	npy2_on	0	49.5728	No	No	No	Yes	8	8
128	5x65	6x26	npy2_on	0	26.6058	No	Yes	No	Yes	8	4
129	5x70	6x26	npy2_on	0	14.2258	No	Yes	No	Yes	0	4
130	6x23	6x27	npy2_on	0	15.8027	No	Yes	No	No	0	4
131	6x23	6x24	npy2_on	0	14.2364	No	Yes	No	No	0	4

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
1x39	2x60	npy2_off	3.75	0	0	0	2	1
1x39	7x38	Shared	8.71	7.62	0	0	2	1
2x53	2x56	Shared	3.42	5.12	0	0	2	1
2x56	3x28	npy2_off	3.42	0	0	1	1	2
2x56	3x32	Shared	9.16	7.63	0	1	1	1
2x60	Lig	Shared	9.97	16.15	0	1	1	0
2x63	E1x50	Shared	8.68	10.13	1	1	1	1
2x63	Lig	Shared	3.6	20.075	1	1	1	0
2x64	2x65	npy2_off	2.95	0	0	0	1	2
E1x50	E1x52	Shared	10.47	12.215	1	1	1	2
3x25	E1x50	Shared	5.22	3.265	1	1	2	1
E1x50	E2.Y189	npy2_off	3.86	0	1	1	1	2
E1x50	Lig	npy2_off	4.2	0	1	1	1	0
3x25	E2.Y189	Shared	4.03	2.015	1	1	2	2
3x25	E2x50	Shared	7.28	7.28	1	1	2	2
3x26	4x65	Shared	3.39	1.13	0	0	2	1
3x28	3x29	Shared	3.53	3.53	0	0	2	2
3x29	4x65	Shared	12.97	10.81	0	0	2	1
3x32	7x38	npy2_off	8.65	0	1	1	1	1
3x32	Lig	Shared	11.46	6.745	1	1	1	0
3x33	Lig	Shared	4.21	2.89	0	0	1	0
3x36	6x48	Shared	6.13	3.675	0	1	1	2
3x36	Lig	Shared	8.25	3.15	0	1	1	0
3x37	4x53	npy2_off	4.33	0	0	0	1	2
3x37	4x56	Shared	3.99	2.66	0	0	1	2
3x37	5x461	Shared	14.64	5.985	0	0	1	2
3x37	Lig	npy2_off	3.27	0	0	0	1	0
4x60	5x39	npy2_off	15.3	0	0	0	2	1
4x61	5x39	Shared	4.69	5.275	1	0	1	1
4x61	Lig	npy2_off	5.96	0	1	0	1	0
4x65	E2x50	npy2_off	4.18	0	0	0	1	2
4x65	E2x52	Shared	5.82	6.4	0	0	1	1
4x65	Lig	npy2_off	8.22	0	0	0	1	0
E2.E188	E2x51	Shared	5.64	6.35	0	1	1	2
E2.E188	E2.K206	Shared	9.45	8.1	0	1	1	2
E2.E193	E2.I200	npy2_off	5.47	0	0	1	1	2
5x39	5x43	npy2_off	7.63	0	1	1	1	1
5x39	Lig	Shared	3.6	10.25	1	1	1	0
5x40	6x59	Shared	7.36	5.89	0	1	1	1
5x40	Lig	Shared	4.62	4.61	0	1	1	0
5x43	Lig	npy2_off	3.69	0	1	0	1	0
5x44	5x47	npy2_off	3.52	0	1	0	1	2
5x44	6x52	Shared	6.43	1.93	1	0	1	1
5x44	Lig	npy2_off	3.41	0	1	0	1	0
5x47	6x52	npy2_off	9.8	0	1	0	2	1
6x48	6x52	Shared	10.58	3.7	1	0	2	1
6x51	6x55	npy2_off	7.99	0	0	0	2	1
6x51	7x34	npy2_off	7.31	0	0	0	2	1
6x52	6x55	npy2_off	6.18	0	1	0	1	1
6x52	Lig	npy2_off	11.07	0	1	0	1	0
6x54	6x58	npy2_off	11.8	0	6	1	2	1
6x54	7x30	Shared	9.28	6.19	6	1	2	1
6x54	7x34	npy2_off	7.5	0	6	1	2	1
6x55	Lig	Shared	12.28	8.175	1	1	1	0
6x58	E3.V297	Shared	3.21	3.21	0	1	1	2
7x30	E3.V297	npy2_off	6.31	0	0	1	1	2
7x26	7x30	npy2_off	3.45	0	0	1	1	1
7x27	7x30	npy2_off	5.86	0	0	0	2	1
7x27	7x31	npy2_off	4.23	0	0	0	2	1
7x32	7x35	npy2_off	4.42	0	0	0	2	1
7x34	Lig	Shared	8.24	6.67	0	1	1	0
7x38	7x42	Shared	13.13	9.195	1	1	1	2
7x38	Lig	Shared	9.49	7.61	1	1	1	0
E2.I194	E2.I200	npy2_off	2.94	0	0	1	1	2
7x27	E3.L298	npy2_off	2.77	0	0	0	2	1
E2.E211	E2.K212	npy2_off	2.7	0	0	1	1	2
7x26	7x29	npy2_off	2.6	0	0	1	1	2
3x33	4x57	npy2_off	1.95	0	0	0	1	2
2x56	3x31	npy2_off	1.81	0	0	1	1	2
7x35	Lig	npy2_off	1.81	0	0	0	1	0
E2.A202	E2.I192	npy2_off	1.62	0	0	0	2	1
E2.E188	E2.S190	Shared	1.44	6.465	0	1	1	2
5x44	6x56	npy2_off	1.38	0	1	0	1	2
7x28	7x29	Shared	1.35	3.375	0	1	1	2
2x63	E2.A202	Shared	1.33	2.665	1	1	1	2
E2.E188	Lig	npy2_on	0	5.05	0	1	1	0
E2.I192	Lig	npy2_on	0	4.84	0	1	1	0
E2.E193	Lig	npy2_on	0	3.375	0	1	1	0
Lig	NT.L40	npy2_on	0	7.46	1	1	0	1
E2.I194	Lig	npy2_on	0	10.975	0	1	1	0
7x28	Lig	npy2_on	0	6.805	0	1	1	0
E3.S295	Lig	npy2_on	0	2.785	0	0	1	0
E3.L298	Lig	npy2_on	0	16.46	0	1	1	0
7x26	Lig	npy2_on	0	4.41	0	1	1	0
7x31	Lig	npy2_on	0	6.58	0	1	1	0
7x30	Lig	npy2_on	0	13.425	0	1	1	0
E2x52	Lig	npy2_on	0	12.21	0	1	1	0
6x58	Lig	npy2_on	0	5.885	0	1	1	0
6x59	Lig	npy2_on	0	4.17	0	1	1	0
2x64	Lig	npy2_on	0	4.25	0	0	1	0
2x56	Lig	npy2_on	0	2.68	0	1	1	0
1x35	7x35	npy2_on	0	2.95	0	0	2	1
1x39	7x35	npy2_on	0	3.745	0	0	2	1
2x60	3x32	npy2_on	0	2.835	0	1	1	1
2x60	7x38	npy2_on	0	10.265	0	1	1	1
3x28	E1x50	npy2_on	0	5.515	0	0	2	1
E1x50	E2x50	npy2_on	0	3.265	1	1	1	2
3x25	4x65	npy2_on	0	2.79	1	1	2	1
3x28	3x32	npy2_on	0	4.3	0	0	2	1
E2.I192	E2.S190	npy2_on	0	3.87	0	1	1	2
E2.F198	E2.I194	npy2_on	0	3.14	0	0	2	1
E2.F198	E2.I200	npy2_on	0	3.14	0	0	2	2
E2.W207	E2x52	npy2_on	0	2.725	5	1	2	1
5x39	E2.W207	npy2_on	0	2.41	1	1	1	2
5x37	6x59	npy2_on	0	4.335	0	0	2	1
5x43	5x461	npy2_on	0	3	1	0	1	2
5x43	6x52	npy2_on	0	2.79	1	0	1	1
6x54	E3.V297	npy2_on	0	2.62	6	1	2	2
6x55	7x34	npy2_on	0	2.34	1	1	1	1
6x58	E3.L298	npy2_on	0	2.98	0	1	1	1
7x30	E3.L298	npy2_on	0	4.69	0	1	1	1
7x29	7x32	npy2_on	0	6.63	0	0	2	2
E2.I192	E2.I200	npy2_on	0	2.945	0	1	1	2
E2.E193	E2.E199	npy2_on	0	10.15	0	1	1	2
5x44	5x45	npy2_on	0	2.075	1	0	1	2
E2.Y189	E2x50	npy2_on	0	2.015	1	1	2	2
7x26	E3.Q296	npy2_on	0	1.96	0	1	1	2
E2.E211	Lig	npy2_on	0	1.57	0	1	1	0
5x37	E2.K212	npy2_on	0	1.5	0	0	2	2
7x31	NT.D42	npy2_on	0	1.385	0	1	1	2
7x26	7x27	npy2_on	0	1.355	0	1	1	2
E2.E210	E2.E211	npy2_on	0	1.27	0	0	2	1
7x35	7x36	npy2_on	0	0.795	0	0	1	2
7x31	NT.T44	npy2_on	0	0.75	0	1	1	2
5x39	5x42	npy2_on	0	0.635	1	1	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	npy2_off	7DDZ-Y₂-JNJ-31020028
	npy2_on	7YOO-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y₂-Peptide YY(3-36)-Gi1/&β;1/&γ;2

Network Difference
Value	npy2_off	npy2_on
I_min	2.95	2.3
Number of Linked Nodes	272	295
Number of Specific Nodes	5 (1.84%)	28 (9.49%)
Number of Shared Nodes	267 (98.16%)	267 (90.51%)
Number of Links	301	331
Number of Specific Links	144 (47.84%)	174 (52.57%)
Number of Shared Links	157 (52.16%)	157 (47.43%)
Number of Hubs	34	39
Number of Specific Hubs	16 (47.06%)	21 (53.85%)
Number of Shared Hubs	18 (52.94%)	18 (46.15%)
Average % Shared Neighbours (Jaccard)	37.34
Average % Shared Neighbours (Otsuka)	45.81
Average % Shared Neighbours (Overlap Coefficient)	53.83
Average % Shared Cliques (k3-6)	76.25
Graphlets Similarity	0.634139

Paths Difference
Value	npy2_off	npy2_on
Number Of Nodes in MetaPath	102	42
Specific Nodes in MetaPath	70 (68.63%)	10 (23.81%)
Shared Nodes in MetaPath	267 (98.16%)	267 (98.16%)
Number Of Links MetaPath	107	40
Specific Links in MetaPath	91 (85.05%)	24 (60.00%)
Shared Links in MetaPath	157 (52.16%)	157 (52.16%)
Number of Shortest Paths	56043	70509
Length Of Smallest Path	3	3
Average Path Length	12.737	12.3825
Length of Longest Path	27	25
Minimum Path Strength	1.32	0.735
Average Path Strength	6.21964	4.74111
Maximum Path Strength	19.365	15.555
Minimum Path Correlation	0.7	0.71
Average Path Correlation	0.925368	0.940883
Maximum Path Correlation	0.99	0.99
Minimum % Of Corr. Nodes	4.16667	5.55556
Average % Of Corr. Nodes	51.0833	60.1392
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	38.2479	47.2698
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

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