psnGPCR

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Orange: nodes, hubs and links specific of npy2_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of npy2_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	npy2_off Int. Strength	npy2_on Int. Strength	npy2_off Hub1?	npy2_on Hub1?	npy2_off Hub2?	npy2_on Hub2?	ConSurf1	ConSurf2
1	E1x50	Lig	npy2_off	4.2	0	Yes	Yes	Yes	Yes	8	0
2	3x37	Lig	npy2_off	3.27	0	Yes	No	Yes	Yes	6	0
3	4x65	Lig	npy2_off	8.22	0	Yes	Yes	Yes	Yes	6	0
4	5x43	Lig	npy2_off	3.69	0	No	No	Yes	Yes	5	0
5	5x44	Lig	npy2_off	3.41	0	Yes	No	Yes	Yes	5	0
6	6x52	Lig	npy2_off	11.07	0	Yes	Yes	Yes	Yes	7	0
7	1x39	2x60	npy2_off	3.75	0	Yes	Yes	No	No	7	6
8	1x42	7x47	npy2_off	10.05	0	No	No	Yes	No	7	7
9	1x45	7x47	npy2_off	8.53	0	No	No	Yes	No	6	7
10	1x50	2x47	npy2_off	4.69	0	No	No	No	No	9	9
11	1x53	7x50	npy2_off	3.53	0	No	No	No	No	9	9
12	1x53	7x53	npy2_off	3.79	0	No	No	Yes	Yes	9	9
13	1x56	1x60	npy2_off	5.24	0	No	No	Yes	No	7	5
14	1x57	2x40	npy2_off	5.91	0	No	No	No	Yes	7	8
15	1x60	I1x50	npy2_off	4.98	0	Yes	No	Yes	No	5	8
16	4x39	I1x48	npy2_off	4.31	0	No	No	No	No	1	6
17	2x38	4x39	npy2_off	3.04	0	No	No	No	No	6	1
18	2x39	3x50	npy2_off	6.47	0	No	No	No	No	8	9
19	2x46	3x43	npy2_off	5.54	0	No	Yes	No	No	9	8
20	2x50	7x46	npy2_off	7.23	0	No	Yes	No	No	9	9
21	2x51	2x55	npy2_off	2.95	0	No	No	No	No	7	5
22	2x56	3x28	npy2_off	3.42	0	Yes	No	No	Yes	6	5
23	2x59	3x24	npy2_off	3.65	0	No	No	No	No	5	6
24	2x64	2x65	npy2_off	2.95	0	No	No	Yes	Yes	4	4
25	E1x50	E2.Y189	npy2_off	3.86	0	Yes	Yes	Yes	No	8	5
26	3x25	E2.Y189	npy2_off	4.03	0	No	No	Yes	No	9	5
27	3x32	7x38	npy2_off	8.65	0	No	Yes	Yes	Yes	6	5
28	3x34	4x50	npy2_off	5.69	0	No	No	Yes	Yes	5	9
29	3x37	4x53	npy2_off	4.33	0	Yes	No	Yes	No	6	8
30	3x39	6x44	npy2_off	3.96	0	No	No	Yes	No	9	9
31	3x43	6x41	npy2_off	2.98	0	No	No	No	No	8	8
32	3x43	6x44	npy2_off	6.09	0	No	No	Yes	No	8	9
33	3x44	5x54	npy2_off	6.08	0	No	No	No	No	7	8
34	3x46	6x37	npy2_off	4.28	0	No	No	Yes	No	9	8
35	3x49	I2.I160	npy2_off	7	0	No	No	No	No	8	5
36	3x50	6x33	npy2_off	9.06	0	No	No	No	No	9	8
37	3x50	6x37	npy2_off	4.86	0	No	No	Yes	No	9	8
38	3x51	3x52	npy2_off	5.14	0	Yes	Yes	Yes	No	8	4
39	3x51	5x61	npy2_off	4.84	0	Yes	Yes	No	No	8	8
40	3x52	3x55	npy2_off	3.92	0	Yes	No	No	No	4	7
41	3x52	3x56	npy2_off	6.17	0	Yes	No	Yes	No	4	7
42	3x52	I2.K159	npy2_off	14.85	0	Yes	No	No	No	4	5
43	3x53	6x30	npy2_off	4.18	0	No	No	Yes	Yes	8	7
44	3x54	6x30	npy2_off	13.78	0	No	No	Yes	Yes	8	7
45	3x56	I2.L156	npy2_off	4.69	0	Yes	No	No	No	7	5
46	3x56	I2.K159	npy2_off	8.36	0	Yes	No	No	No	7	5
47	6x26	I2.E157	npy2_off	5.61	0	No	Yes	No	No	4	4
48	6x30	I2.E157	npy2_off	10.47	0	Yes	Yes	No	No	7	4
49	4x39	4x40	npy2_off	3.71	0	No	No	No	No	1	5
50	4x40	4x43	npy2_off	7.48	0	No	No	No	No	5	4
51	4x42	4x43	npy2_off	3.96	0	No	No	No	No	7	4
52	4x48	4x52	npy2_off	4.28	0	No	No	No	No	3	4
53	4x60	5x39	npy2_off	15.3	0	No	No	Yes	No	8	6
54	4x65	E2x50	npy2_off	4.18	0	Yes	Yes	No	No	6	9
55	E2.E193	E2.I200	npy2_off	5.47	0	No	No	No	No	2	3
56	5x35	E2.P208	npy2_off	9.74	0	No	No	Yes	No	3	4
57	E2.G209	E2.K212	npy2_off	3.49	0	No	No	No	No	4	3
58	5x34	5x35	npy2_off	3.63	0	No	No	No	No	1	3
59	5x39	5x43	npy2_off	7.63	0	Yes	No	No	No	6	5
60	5x44	5x47	npy2_off	3.52	0	Yes	No	No	No	5	8
61	5x45	5x46	npy2_off	4.28	0	No	No	No	No	5	4
62	5x54	6x41	npy2_off	4.61	0	No	No	No	No	8	8
63	5x56	5x57	npy2_off	3.96	0	No	No	No	No	4	7
64	5x58	6x38	npy2_off	8.83	0	No	Yes	No	No	9	6
65	5x61	6x34	npy2_off	3.04	0	No	No	No	No	8	6
66	5x62	6x35	npy2_off	5.8	0	No	No	No	No	5	6
67	5x65	6x34	npy2_off	2.95	0	No	Yes	No	No	8	6
68	5x66	5x67	npy2_off	4.2	0	No	No	No	No	6	4
69	5x68	6x27	npy2_off	15.53	0	No	No	No	No	6	4
70	6x26	6x29	npy2_off	4.12	0	No	Yes	No	No	4	5
71	6x27	6x31	npy2_off	12.36	0	No	No	No	No	4	5
72	6x28	6x32	npy2_off	6.78	0	No	No	No	No	4	8
73	6x33	6x37	npy2_off	2.95	0	No	No	Yes	No	8	8
74	6x34	6x35	npy2_off	7.51	0	No	No	No	No	6	6
75	6x36	7x53	npy2_off	8.38	0	No	No	Yes	Yes	8	9
76	6x36	8x47	npy2_off	8.41	0	No	No	No	No	8	8
77	6x39	7x56	npy2_off	6.48	0	No	No	No	No	6	7
78	6x40	7x49	npy2_off	8.87	0	No	No	No	No	8	9
79	6x44	7x45	npy2_off	3.96	0	Yes	No	No	No	9	9
80	6x47	7x40	npy2_off	3.27	0	No	No	No	No	8	7
81	6x50	7x40	npy2_off	3.39	0	No	No	No	No	9	7
82	6x51	6x55	npy2_off	7.99	0	No	No	No	No	6	5
83	6x52	6x55	npy2_off	6.18	0	Yes	Yes	No	No	7	5
84	6x54	7x34	npy2_off	7.5	0	Yes	Yes	No	No	4	4
85	6x61	E3.V297	npy2_off	4.38	0	No	No	No	No	2	6
86	7x30	E3.V297	npy2_off	6.31	0	Yes	No	No	No	4	6
87	7x26	7x30	npy2_off	3.45	0	No	No	Yes	No	1	4
88	7x27	7x30	npy2_off	5.86	0	No	No	Yes	No	1	4
89	7x32	7x35	npy2_off	4.42	0	No	No	No	No	1	3
90	7x49	7x53	npy2_off	5.81	0	No	No	Yes	Yes	9	9
91	7x53	8x50	npy2_off	6.95	0	Yes	Yes	Yes	Yes	9	8
92	7x54	8x54	npy2_off	3.01	0	No	No	No	Yes	7	6
93	7x55	7x56	npy2_off	8.14	0	No	No	No	No	6	7
94	8x48	8x51	npy2_off	5.27	0	No	No	No	No	5	8
95	8x48	8x52	npy2_off	6.12	0	No	No	No	No	5	4
96	E2.I194	E2.I200	npy2_off	2.94	0	No	No	No	No	1	3
97	1x42	7x42	npy2_off	2.92	0	No	No	No	No	7	7
98	6x33	8x47	npy2_off	2.92	0	No	No	No	No	8	8
99	1x30	1x33	npy2_off	2.85	0	No	No	No	No	2	6
100	E2.D197	E2.I195	npy2_off	2.8	0	No	No	No	No	4	2
101	2x52	2x551	npy2_off	2.77	0	No	No	No	No	7	5
102	7x27	E3.L298	npy2_off	2.77	0	No	No	No	No	1	1
103	E2.E211	E2.K212	npy2_off	2.7	0	No	No	No	No	2	3
104	3x30	4x54	npy2_off	2.67	0	No	No	No	No	6	4
105	5x65	6x31	npy2_off	2.66	0	No	Yes	No	No	8	5
106	8x56	8x59	npy2_off	2.64	0	No	No	No	No	4	3
107	7x26	7x29	npy2_off	2.6	0	No	No	No	No	1	3
108	2x49	4x50	npy2_off	2.59	0	No	No	Yes	Yes	8	9
109	7x47	7x51	npy2_off	2.44	0	Yes	No	No	No	7	7
110	6x29	8x49	npy2_off	2.41	0	No	No	No	No	5	6
111	E2.G209	E2.P208	npy2_off	2.03	0	No	No	Yes	No	4	4
112	3x33	4x57	npy2_off	1.95	0	No	No	No	No	4	7
113	7x35	Lig	npy2_off	1.81	0	No	No	Yes	Yes	3	0
114	2x56	3x31	npy2_off	1.81	0	Yes	No	No	No	6	5
115	1x56	8x57	npy2_off	1.7	0	No	No	No	No	7	4
116	1x40	1x43	npy2_off	1.64	0	No	No	Yes	No	4	6
117	1x54	2x47	npy2_off	1.62	0	No	No	No	No	7	9
118	E2.A202	E2.I192	npy2_off	1.62	0	No	No	No	No	4	2
119	5x38	5x42	npy2_off	1.62	0	No	No	No	No	4	3
120	5x55	5x59	npy2_off	1.6	0	No	No	No	No	5	3
121	6x41	6x42	npy2_off	1.6	0	No	No	No	No	8	4
122	6x42	6x46	npy2_off	1.6	0	No	No	No	No	4	6
123	1x37	1x40	npy2_off	1.59	0	No	No	No	No	6	4
124	5x37	5x38	npy2_off	1.59	0	No	No	No	No	3	4
125	3x41	4x53	npy2_off	1.55	0	No	No	Yes	No	5	8
126	1x43	1x47	npy2_off	1.54	0	Yes	No	No	No	6	6
127	1x47	1x48	npy2_off	1.54	0	No	No	No	No	6	4
128	I1x49	I1x50	npy2_off	1.53	0	No	No	Yes	No	5	8
129	1x51	2x51	npy2_off	1.5	0	No	No	No	No	4	7
130	E2.L191	E2.S190	npy2_off	1.5	0	No	No	No	No	3	1
131	1x31	7x32	npy2_off	1.49	0	No	No	No	No	4	1
132	1x34	1x35	npy2_off	1.49	0	No	No	No	No	5	5
133	3x23	3x24	npy2_off	1.49	0	No	No	No	No	2	6
134	3x23	3x27	npy2_off	1.49	0	No	No	No	No	2	5
135	5x44	6x56	npy2_off	1.38	0	Yes	No	No	No	5	5
136	E1x49	E2.I200	npy2_off	1.37	0	Yes	No	No	No	5	3
137	7x36	7x37	npy2_off	1.31	0	No	No	Yes	No	6	6
138	E1x49	E2.E199	npy2_off	1.27	0	Yes	No	No	No	5	4
139	2x60	Lig	Shared	9.97	12.07	No	No	Yes	Yes	6	0
140	2x63	Lig	Shared	3.6	21.26	No	No	Yes	Yes	5	0
141	3x32	Lig	Shared	11.46	5.62	No	Yes	Yes	Yes	6	0
142	3x33	Lig	Shared	4.21	2.89	No	No	Yes	Yes	4	0
143	3x36	Lig	Shared	8.25	3.78	No	No	Yes	Yes	7	0
144	4x61	Lig	Shared	5.96	3.55	No	No	Yes	Yes	5	0
145	5x39	Lig	Shared	3.6	10.25	Yes	No	Yes	Yes	6	0
146	5x40	Lig	Shared	4.62	5.27	No	No	Yes	Yes	4	0
147	6x55	Lig	Shared	12.28	9.34	No	No	Yes	Yes	5	0
148	7x34	Lig	Shared	8.24	7.77	No	No	Yes	Yes	4	0
149	7x38	Lig	Shared	9.49	7.61	Yes	Yes	Yes	Yes	5	0
150	1x31	1x35	Shared	2.98	1.49	No	No	No	No	4	5
151	1x32	2x65	Shared	6.65	3.99	No	No	Yes	Yes	4	4
152	1x36	2x65	Shared	8.56	2.85	No	No	Yes	Yes	6	4
153	1x39	2x61	Shared	3.52	11.72	Yes	Yes	No	No	7	6
154	1x39	7x38	Shared	8.71	7.62	Yes	Yes	Yes	Yes	7	5
155	1x39	7x39	Shared	10.88	7.25	Yes	Yes	No	No	7	5
156	1x43	2x57	Shared	4.28	5.71	Yes	No	No	Yes	6	7
157	1x43	2x58	Shared	3.39	3.39	Yes	No	No	No	6	8
158	1x44	1x48	Shared	7.14	2.85	No	No	No	No	5	4
159	1x46	2x54	Shared	3.39	3.39	No	No	No	No	7	6
160	1x47	2x51	Shared	2.98	2.98	No	No	No	No	6	7
161	1x49	7x50	Shared	4.06	2.03	No	No	No	No	8	9
162	1x50	2x50	Shared	5.39	4.04	No	No	No	Yes	9	9
163	1x50	7x50	Shared	9.77	6.52	No	No	No	No	9	9
164	1x52	8x54	Shared	9.74	2.44	No	No	No	Yes	7	6
165	1x52	8x58	Shared	8.53	3.65	No	No	No	No	7	5
166	1x53	2x47	Shared	3.39	3.39	No	No	No	No	9	9
167	1x54	2x48	Shared	4.61	3.07	No	No	No	No	7	6
168	1x55	1x59	Shared	3.93	6.55	No	No	No	No	4	5
169	1x56	8x53	Shared	5.09	3.39	No	No	No	No	7	6
170	1x57	2x44	Shared	5.09	1.7	No	No	No	No	7	6
171	1x60	8x56	Shared	3.96	1.32	Yes	No	No	No	5	4
172	I1x48	I1x51	Shared	13.61	4.95	No	No	No	No	6	6
173	8x50	I1x50	Shared	8.38	2.39	Yes	Yes	Yes	No	8	8
174	8x53	I1x50	Shared	3.22	3.22	No	No	Yes	No	6	8
175	2x37	2x40	Shared	7.31	4.39	No	No	No	Yes	7	8
176	2x38	2x42	Shared	3.93	2.62	No	No	Yes	Yes	6	7
177	2x38	4x42	Shared	4.85	9.7	No	No	No	No	6	7
178	2x40	8x50	Shared	11.63	4.65	No	Yes	Yes	Yes	8	8
179	2x41	4x43	Shared	9.65	1.07	No	Yes	No	No	5	4
180	2x42	3x45	Shared	5.24	7.87	Yes	Yes	No	No	7	7
181	2x42	3x46	Shared	5.02	2.51	Yes	Yes	No	No	7	9
182	2x42	4x46	Shared	5.02	5.02	Yes	Yes	No	Yes	7	7
183	2x43	7x53	Shared	12.09	3.63	No	No	Yes	Yes	8	9
184	2x43	8x50	Shared	4.84	9.67	No	No	Yes	Yes	8	8
185	2x45	3x42	Shared	8.77	2.92	No	No	No	No	9	8
186	2x45	4x46	Shared	15.58	8.5	No	No	No	Yes	9	7
187	2x45	4x50	Shared	7.91	6.78	No	No	Yes	Yes	9	9
188	2x46	3x39	Shared	3	3	No	Yes	No	No	9	9
189	2x46	3x42	Shared	5.9	5.9	No	Yes	No	No	9	8
190	2x53	2x56	Shared	3.42	5.12	No	No	Yes	No	7	6
191	2x54	7x46	Shared	10.24	13.16	No	No	No	No	6	9
192	2x56	3x32	Shared	9.16	9.16	Yes	No	No	Yes	6	6
193	2x57	7x42	Shared	8.48	7.07	No	Yes	No	No	7	7
194	2x59	E1x52	Shared	7.46	6.22	No	No	Yes	Yes	5	7
195	2x61	2x65	Shared	4.15	4.15	No	No	Yes	Yes	6	4
196	2x62	E1x52	Shared	3.01	3.01	No	No	Yes	Yes	4	7
197	2x63	E1x50	Shared	8.68	9.65	No	No	Yes	Yes	5	8
198	2x66	E1x51	Shared	4.32	4.32	No	No	No	No	4	3
199	E1x49	E2.V201	Shared	4.28	2.85	Yes	No	No	No	5	4
200	E1x50	E1x52	Shared	10.47	15.12	Yes	Yes	Yes	Yes	8	7
201	3x25	E1x50	Shared	5.22	5.22	No	No	Yes	Yes	9	8
202	3x24	E1x52	Shared	4.24	4.24	No	No	Yes	Yes	6	7
203	3x21	3x22	Shared	4.06	4.06	No	No	No	No	8	3
204	3x22	E2.Y189	Shared	18.08	11.13	No	No	Yes	No	3	5
205	3x25	E2x50	Shared	7.28	7.28	No	No	No	No	9	9
206	3x26	4x65	Shared	3.39	1.13	No	No	Yes	Yes	7	6
207	3x28	3x29	Shared	3.53	3.53	No	Yes	No	No	5	5
208	3x29	4x65	Shared	12.97	11.53	No	No	Yes	Yes	5	6
209	3x30	4x62	Shared	4	1.33	No	No	No	No	6	5
210	3x34	4x53	Shared	4.5	3	No	No	Yes	No	5	8
211	3x36	6x48	Shared	6.13	2.45	No	No	Yes	Yes	7	8
212	3x37	4x56	Shared	3.99	1.33	Yes	No	No	No	6	5
213	3x37	5x461	Shared	14.64	5.32	Yes	No	No	No	6	6
214	3x38	4x50	Shared	17.16	12.26	No	No	Yes	Yes	7	9
215	3x38	4x53	Shared	4.85	3.23	No	No	Yes	No	7	8
216	3x40	5x50	Shared	3.5	3.5	No	No	No	No	8	9
217	3x41	4x49	Shared	3.25	1.62	No	No	No	No	5	7
218	3x44	5x50	Shared	5.25	3.5	No	No	No	No	7	9
219	3x44	5x53	Shared	3.04	4.56	No	No	No	No	7	6
220	3x45	4x45	Shared	3.07	3.07	No	No	No	No	7	5
221	3x47	5x54	Shared	4.87	3.25	No	No	No	No	9	8
222	3x47	5x57	Shared	3.42	1.71	No	No	No	No	9	7
223	3x47	5x58	Shared	5.34	4	No	No	No	Yes	9	9
224	3x49	3x53	Shared	4.67	1.56	No	No	No	No	8	8
225	3x51	3x55	Shared	5.05	7.57	Yes	Yes	No	No	8	7
226	3x51	5x60	Shared	16.46	7.2	Yes	Yes	No	No	8	4
227	3x55	3x56	Shared	3.79	6.31	No	No	Yes	No	7	7
228	4x59	4x60	Shared	5.34	5.34	No	No	No	No	4	8
229	4x61	5x39	Shared	4.69	7.03	No	No	Yes	No	5	6
230	4x64	E2.W207	Shared	26.06	8.02	Yes	Yes	No	Yes	5	5
231	4x64	E2.P208	Shared	5.78	10.11	Yes	Yes	Yes	No	5	4
232	4x65	E2x52	Shared	5.82	5.82	Yes	Yes	No	No	6	4
233	E2.E188	E2x51	Shared	5.64	7.06	No	Yes	No	No	4	4
234	E2.E188	E2.K206	Shared	9.45	9.45	No	Yes	No	No	4	3
235	E2.V201	E2.Y189	Shared	6.31	5.05	No	No	Yes	No	4	5
236	E2.I195	E2.P196	Shared	3.39	5.08	No	No	No	No	2	3
237	E2.P208	E2.W207	Shared	5.4	2.7	Yes	No	No	Yes	4	5
238	5x36	E2.W207	Shared	12.67	8.44	No	No	No	Yes	4	5
239	5x40	6x59	Shared	7.36	4.42	No	No	No	No	4	5
240	5x44	6x52	Shared	6.43	1.29	Yes	No	Yes	Yes	5	7
241	5x45	5x48	Shared	2.98	2.98	No	No	No	No	5	4
242	5x47	5x51	Shared	8.21	3.52	No	No	No	Yes	8	5
243	5x47	6x52	Shared	9.8	2.18	No	No	Yes	Yes	8	7
244	5x49	5x50	Shared	4.93	4.93	No	No	No	No	6	9
245	5x51	6x45	Shared	4.73	1.58	No	Yes	No	No	5	5
246	5x56	5x60	Shared	11.76	3.21	No	No	No	No	4	4
247	5x58	6x37	Shared	4.69	5.86	No	Yes	Yes	No	9	8
248	5x62	5x63	Shared	3.71	2.47	No	No	No	No	5	4
249	5x65	6x30	Shared	3.64	2.43	No	Yes	Yes	Yes	8	7
250	6x25	6x29	Shared	5.64	14.67	No	No	No	No	4	5
251	6x40	7x52	Shared	4.47	7.45	No	No	No	Yes	8	8
252	6x40	7x53	Shared	3.79	7.57	No	No	Yes	Yes	8	9
253	6x44	6x48	Shared	14.03	6.01	Yes	No	Yes	Yes	9	8
254	6x48	6x52	Shared	10.58	3.17	Yes	Yes	Yes	Yes	8	7
255	6x48	7x41	Shared	7.78	2.59	Yes	Yes	No	No	8	7
256	6x48	7x45	Shared	4.94	2.47	Yes	Yes	No	No	8	9
257	6x49	6x50	Shared	3.28	3.28	No	No	No	No	5	9
258	6x50	7x37	Shared	10.11	5.78	No	No	Yes	No	9	6
259	6x51	7x34	Shared	7.31	2.44	No	No	No	No	6	4
260	6x54	6x58	Shared	11.8	2.62	Yes	Yes	No	No	4	4
261	6x54	7x30	Shared	9.28	6.19	Yes	Yes	Yes	No	4	4
262	6x54	7x33	Shared	6.28	3.77	Yes	Yes	No	No	4	5
263	6x54	7x37	Shared	6.43	8.57	Yes	Yes	Yes	No	4	6
264	6x58	E3.V297	Shared	3.21	3.21	No	No	No	No	4	6
265	6x61	E3.Q296	Shared	5.22	15.66	No	No	No	No	2	5
266	7x33	7x37	Shared	5.02	3.77	No	No	Yes	No	5	6
267	7x38	7x42	Shared	13.13	10.51	Yes	Yes	No	No	5	7
268	7x43	7x47	Shared	6.98	6.98	No	No	Yes	No	5	7
269	7x52	7x56	Shared	4.24	1.41	No	Yes	No	No	8	7
270	8x47	8x50	Shared	11.63	4.65	No	No	Yes	Yes	8	8
271	8x50	8x54	Shared	5.16	2.06	Yes	Yes	No	Yes	8	6
272	4x41	I2.I160	Shared	2.94	1.47	No	No	No	No	5	5
273	4x41	4x45	Shared	2.94	1.47	No	No	No	No	5	5
274	3x54	5x64	Shared	2.91	1.45	No	No	No	No	8	5
275	4x60	4x64	Shared	2.89	2.89	No	No	Yes	Yes	8	5
276	3x48	5x53	Shared	2.85	4.28	No	No	No	No	6	6
277	4x52	4x56	Shared	2.85	2.85	No	No	No	No	4	5
278	4x44	4x48	Shared	2.77	6.92	No	No	No	No	3	3
279	E1x49	E1x51	Shared	2.7	14.85	Yes	No	No	No	5	3
280	3x30	4x57	Shared	2.67	2.67	No	No	No	No	6	7
281	1x59	1x60	Shared	2.48	6.2	No	No	Yes	No	5	5
282	5x62	5x66	Shared	2.32	8.12	No	No	No	No	5	6
283	2x52	4x50	Shared	2.28	2.28	No	No	Yes	Yes	7	9
284	1x48	1x49	Shared	1.76	3.53	No	No	No	No	4	8
285	2x66	2x67	Shared	1.75	1.75	No	No	No	No	4	5
286	6x43	6x47	Shared	1.71	1.71	No	No	No	No	6	8
287	2x53	3x35	Shared	1.7	1.7	No	No	No	No	7	7
288	6x43	7x48	Shared	1.7	1.7	No	No	No	No	6	6
289	1x38	7x39	Shared	1.62	1.62	No	No	No	No	5	5
290	6x38	6x42	Shared	1.6	1.6	No	No	No	No	6	4
291	E2.L191	E2.V201	Shared	1.49	1.49	No	No	No	No	3	4
292	1x54	1x58	Shared	1.47	2.94	No	No	No	No	7	3
293	E2.E188	E2.S190	Shared	1.44	4.31	No	Yes	No	No	4	1
294	5x46	5x461	Shared	1.43	2.85	No	No	No	No	4	6
295	5x41	6x56	Shared	1.38	2.77	No	No	No	No	4	5
296	7x28	7x29	Shared	1.35	4.05	No	No	No	No	3	3
297	2x63	E2.A202	Shared	1.33	4	No	No	No	No	5	4
298	4x63	4x64	Shared	1.26	6.28	No	No	Yes	Yes	4	5
299	Lig	Lig	npy2_on	0	106.55	Yes	Yes	Yes	Yes	0	0
300	E2.E188	Lig	npy2_on	0	10.1	No	Yes	Yes	Yes	4	0
301	E2.I192	Lig	npy2_on	0	6.05	No	No	Yes	Yes	2	0
302	E2x51	Lig	npy2_on	0	4.29	No	No	Yes	Yes	4	0
303	E2.E211	Lig	npy2_on	0	3.14	No	No	Yes	Yes	2	0
304	E2.E193	Lig	npy2_on	0	6.75	No	No	Yes	Yes	2	0
305	Lig	NT.L40	npy2_on	0	9.56	Yes	Yes	No	No	0	0
306	E2.I194	Lig	npy2_on	0	9.68	No	No	Yes	Yes	1	0
307	7x28	Lig	npy2_on	0	3.71	No	No	Yes	Yes	3	0
308	E3.L298	Lig	npy2_on	0	15.9	No	No	Yes	Yes	1	0
309	E2.I200	Lig	npy2_on	0	2.94	No	No	Yes	Yes	3	0
310	7x31	Lig	npy2_on	0	7.15	No	No	Yes	Yes	4	0
311	7x30	Lig	npy2_on	0	12.26	Yes	No	Yes	Yes	4	0
312	E2x52	Lig	npy2_on	0	12.79	No	No	Yes	Yes	4	0
313	6x58	Lig	npy2_on	0	5.23	No	No	Yes	Yes	4	0
314	6x59	Lig	npy2_on	0	5.96	No	No	Yes	Yes	5	0
315	2x64	Lig	npy2_on	0	4.25	No	No	Yes	Yes	4	0
316	2x56	Lig	npy2_on	0	2.68	Yes	No	Yes	Yes	6	0
317	7x29	NT.S43	npy2_on	0	10.06	No	No	No	No	3	0
318	1x28	1x31	npy2_on	0	4.47	No	No	No	No	0	4
319	1x35	2x61	npy2_on	0	2.77	No	No	No	No	5	6
320	1x35	7x35	npy2_on	0	5.9	No	No	No	No	5	3
321	1x39	2x57	npy2_on	0	3.52	Yes	Yes	No	Yes	7	7
322	1x39	7x35	npy2_on	0	4.99	Yes	Yes	No	No	7	3
323	1x42	2x57	npy2_on	0	2.85	No	No	No	Yes	7	7
324	1x45	1x46	npy2_on	0	1.71	No	No	No	No	6	7
325	1x50	2x51	npy2_on	0	5.49	No	No	No	No	9	7
326	1x53	8x50	npy2_on	0	3.79	No	No	Yes	Yes	9	8
327	1x56	8x50	npy2_on	0	2.52	No	No	Yes	Yes	7	8
328	1x56	8x54	npy2_on	0	6.55	No	No	No	Yes	7	6
329	1x57	8x50	npy2_on	0	3.79	No	No	Yes	Yes	7	8
330	2x40	I1x50	npy2_on	0	5.61	No	Yes	Yes	No	8	8
331	2x41	I1x51	npy2_on	0	4.28	No	Yes	No	No	5	6
332	2x38	I2.I160	npy2_on	0	3.07	No	No	No	No	6	5
333	2x39	2x40	npy2_on	0	2.92	No	No	No	Yes	8	8
334	2x39	3x49	npy2_on	0	4.34	No	No	No	No	8	8
335	2x41	4x39	npy2_on	0	3.72	No	Yes	No	No	5	1
336	2x42	3x49	npy2_on	0	3.58	Yes	Yes	No	No	7	8
337	2x42	4x42	npy2_on	0	2.64	Yes	Yes	No	No	7	7
338	2x46	2x50	npy2_on	0	5.43	No	Yes	No	Yes	9	9
339	2x46	7x49	npy2_on	0	6.87	No	Yes	No	No	9	9
340	2x46	7x53	npy2_on	0	2.34	No	Yes	Yes	Yes	9	9
341	2x48	4x50	npy2_on	0	2.45	No	No	Yes	Yes	6	9
342	2x49	3x38	npy2_on	0	3.39	No	No	No	No	8	7
343	2x49	3x39	npy2_on	0	1.71	No	No	No	No	8	9
344	2x50	3x39	npy2_on	0	4.42	No	Yes	No	No	9	9
345	2x50	7x49	npy2_on	0	6.73	No	Yes	No	No	9	9
346	2x53	7x46	npy2_on	0	3.17	No	No	No	No	7	9
347	2x54	2x57	npy2_on	0	4.12	No	No	No	Yes	6	7
348	2x551	2x59	npy2_on	0	2.44	No	No	No	No	5	5
349	2x551	3x31	npy2_on	0	3.15	No	No	No	No	5	5
350	2x57	2x58	npy2_on	0	3.28	No	Yes	No	No	7	8
351	2x57	7x38	npy2_on	0	2.57	No	Yes	Yes	Yes	7	5
352	2x59	3x28	npy2_on	0	9.18	No	No	No	Yes	5	5
353	2x60	3x32	npy2_on	0	4.25	No	No	No	Yes	6	6
354	2x60	7x38	npy2_on	0	10.95	No	No	Yes	Yes	6	5
355	2x62	2x66	npy2_on	0	3.01	No	No	No	No	4	4
356	3x28	E1x50	npy2_on	0	6.13	No	Yes	Yes	Yes	5	8
357	E1x50	E2x50	npy2_on	0	2.61	Yes	Yes	No	No	8	9
358	3x21	E1x52	npy2_on	0	1.75	No	No	Yes	Yes	8	7
359	3x24	3x28	npy2_on	0	2.98	No	No	No	Yes	6	5
360	3x25	4x65	npy2_on	0	2.79	No	No	Yes	Yes	9	6
361	3x28	3x32	npy2_on	0	4.3	No	Yes	No	Yes	5	6
362	3x33	4x61	npy2_on	0	1.71	No	No	No	No	4	5
363	3x40	6x44	npy2_on	0	2.59	No	No	Yes	No	8	9
364	3x43	7x53	npy2_on	0	4.69	No	No	Yes	Yes	8	9
365	3x46	3x50	npy2_on	0	5.01	No	No	No	No	9	9
366	3x46	7x53	npy2_on	0	4.84	No	No	Yes	Yes	9	9
367	3x50	5x58	npy2_on	0	4.12	No	No	No	Yes	9	9
368	3x50	7x53	npy2_on	0	2.06	No	No	Yes	Yes	9	9
369	3x51	3x56	npy2_on	0	9.93	Yes	Yes	Yes	No	8	7
370	3x51	5x56	npy2_on	0	2.06	Yes	Yes	No	No	8	4
371	3x51	5x57	npy2_on	0	3.82	Yes	Yes	No	No	8	7
372	3x52	I2.I160	npy2_on	0	5.01	Yes	No	No	No	4	5
373	3x53	I2.K159	npy2_on	0	3.23	No	No	No	No	8	5
374	3x54	5x61	npy2_on	0	2.94	No	No	No	No	8	8
375	I2.H155	I2.L156	npy2_on	0	6.43	No	No	No	No	8	5
376	5x64	I2.H155	npy2_on	0	5.24	No	No	No	No	5	8
377	4x38	4x40	npy2_on	0	2.64	No	No	No	No	6	5
378	4x46	4x47	npy2_on	0	1.76	No	Yes	No	No	7	4
379	4x46	4x50	npy2_on	0	2.35	No	Yes	Yes	Yes	7	9
380	4x59	4x63	npy2_on	0	3.1	No	No	No	No	4	4
381	4x64	5x35	npy2_on	0	2.06	Yes	Yes	No	No	5	3
382	E2.Y189	E2x50	npy2_on	0	4.03	Yes	No	No	No	5	9
383	E2.I192	E2.S190	npy2_on	0	4.64	No	No	No	No	2	1
384	E2.E199	E2.L191	npy2_on	0	3.98	No	No	No	No	4	3
385	E2.F198	E2.I194	npy2_on	0	6.28	No	No	No	No	1	1
386	E2.F198	E2.I195	npy2_on	0	5.02	No	No	No	No	1	2
387	E2.F198	E2.I200	npy2_on	0	6.28	No	No	No	No	1	3
388	E2.W207	E2x52	npy2_on	0	3.27	No	Yes	No	No	5	4
389	5x39	E2.W207	npy2_on	0	1.93	Yes	No	No	Yes	6	5
390	5x33	E2.G209	npy2_on	0	1.86	No	No	No	No	2	4
391	5x34	5x37	npy2_on	0	3.04	No	No	No	No	1	3
392	5x35	5x38	npy2_on	0	2.52	No	No	No	No	3	4
393	5x37	6x59	npy2_on	0	2.89	No	No	No	No	3	5
394	5x43	5x461	npy2_on	0	4.5	No	No	No	No	5	6
395	5x43	6x52	npy2_on	0	2.79	No	No	Yes	Yes	5	7
396	5x47	6x49	npy2_on	0	12.89	No	No	No	No	8	5
397	5x49	5x53	npy2_on	0	2.85	No	No	No	No	6	6
398	5x51	5x55	npy2_on	0	3	No	Yes	No	No	5	5
399	5x51	6x44	npy2_on	0	2.44	No	Yes	Yes	No	5	9
400	5x54	5x58	npy2_on	0	2.42	No	No	No	Yes	8	9
401	5x57	5x58	npy2_on	0	5.09	No	No	No	Yes	7	9
402	5x58	5x61	npy2_on	0	2.42	No	Yes	No	No	9	8
403	5x58	6x40	npy2_on	0	3.79	No	Yes	No	No	9	8
404	5x58	6x41	npy2_on	0	2.52	No	Yes	No	No	9	8
405	5x58	7x53	npy2_on	0	1.99	No	Yes	Yes	Yes	9	9
406	5x61	5x65	npy2_on	0	2.85	No	No	No	Yes	8	8
407	5x62	6x34	npy2_on	0	4.85	No	No	No	No	5	6
408	5x65	6x26	npy2_on	0	3.52	No	Yes	No	Yes	8	4
409	5x66	6x30	npy2_on	0	12.38	No	No	Yes	Yes	6	7
410	5x68	6x26	npy2_on	0	5.44	No	No	No	Yes	6	4
411	5x69	6x23	npy2_on	0	4.43	No	No	No	No	4	0
412	5x70	5x71	npy2_on	0	3.56	No	Yes	No	No	0	0
413	5x70	I3.A255	npy2_on	0	1.71	No	Yes	No	No	0	0
414	5x70	6x26	npy2_on	0	3.82	No	Yes	No	Yes	0	4
415	6x24	6x28	npy2_on	0	5.22	No	No	No	No	4	4
416	6x26	6x27	npy2_on	0	10.89	No	Yes	No	No	4	4
417	6x26	6x30	npy2_on	0	5.14	No	Yes	Yes	Yes	4	7
418	6x27	6x30	npy2_on	0	6.77	No	No	Yes	Yes	4	7
419	6x30	6x31	npy2_on	0	4.67	Yes	Yes	No	No	7	5
420	6x36	7x56	npy2_on	0	5.78	No	No	No	No	8	7
421	6x39	7x52	npy2_on	0	3.17	No	No	No	Yes	6	8
422	6x43	7x52	npy2_on	0	2.98	No	No	No	Yes	6	8
423	6x47	7x43	npy2_on	0	1.82	No	No	No	No	8	5
424	6x47	7x45	npy2_on	0	3.44	No	No	No	No	8	9
425	6x48	7x42	npy2_on	0	2.33	Yes	Yes	No	No	8	7
426	6x51	7x41	npy2_on	0	3.15	No	No	No	No	6	7
427	6x54	E3.V297	npy2_on	0	2.62	Yes	Yes	No	No	4	6
428	6x55	7x34	npy2_on	0	2.34	No	No	No	No	5	4
429	7x26	E3.Q296	npy2_on	0	2.61	No	No	No	No	1	5
430	7x30	E3.L298	npy2_on	0	4.69	Yes	No	No	No	4	1
431	7x26	7x27	npy2_on	0	2.71	No	No	No	No	1	1
432	7x29	7x32	npy2_on	0	6.63	No	No	No	No	3	1
433	7x46	7x47	npy2_on	0	2.59	No	No	Yes	No	9	7
434	7x55	8x51	npy2_on	0	9	No	No	No	No	6	8
435	7x55	8x54	npy2_on	0	9.02	No	No	No	Yes	6	6
436	8x47	8x48	npy2_on	0	2.98	No	No	No	No	8	5
437	8x47	8x49	npy2_on	0	4.09	No	No	No	No	8	6
438	8x48	8x49	npy2_on	0	4.47	No	No	No	No	5	6
439	8x55	8x59	npy2_on	0	7.29	No	No	No	No	4	3
440	6x45	6x46	npy2_on	0	1.7	No	No	No	No	5	6
441	1x59	8x57	npy2_on	0	1.61	No	No	No	No	5	4
442	E2.D197	E2.P196	npy2_on	0	1.61	No	No	No	No	4	3
443	1x33	1x34	npy2_on	0	1.6	No	No	No	No	6	5
444	3x34	4x54	npy2_on	0	1.58	No	No	No	No	5	4
445	3x34	4x57	npy2_on	0	1.58	No	No	No	No	5	7
446	4x54	4x55	npy2_on	0	1.58	No	No	No	No	4	4
447	4x38	4x41	npy2_on	0	1.55	No	No	No	No	6	5
448	5x37	6x60	npy2_on	0	1.52	No	No	No	No	3	4
449	1x41	1x45	npy2_on	0	1.5	No	No	No	No	5	6
450	1x51	1x52	npy2_on	0	1.5	No	No	No	No	4	7
451	1x33	1x37	npy2_on	0	1.49	No	No	No	No	6	6
452	5x44	5x48	npy2_on	0	1.49	Yes	No	No	No	5	4
453	5x63	5x67	npy2_on	0	1.49	No	No	No	No	4	4
454	5x70	6x23	npy2_on	0	1.49	No	Yes	No	No	0	0
455	7x27	E3.V297	npy2_on	0	1.49	No	No	No	No	1	6
456	2x65	NT.T44	npy2_on	0	1.47	Yes	Yes	No	No	4	0
457	5x65	6x33	npy2_on	0	1.47	No	Yes	No	No	8	8
458	6x56	6x60	npy2_on	0	1.43	No	No	No	No	5	4
459	E3.S295	Lig	npy2_on	0	1.39	No	No	Yes	Yes	1	0
460	8x57	8x58	npy2_on	0	1.39	No	No	No	No	4	5
461	7x28	NT.D42	npy2_on	0	1.38	No	No	No	No	3	0
462	1x29	1x30	npy2_on	0	1.37	No	No	No	No	0	2
463	1x29	1x32	npy2_on	0	1.37	No	No	No	No	0	4
464	6x23	6x24	npy2_on	0	1.35	No	No	No	No	0	4
465	3x52	I2.S158	npy2_on	0	1.32	Yes	No	No	No	4	5
466	1x57	2x41	npy2_on	0	1.31	No	No	No	Yes	7	5
467	4x49	4x50	npy2_on	0	1.3	No	No	Yes	Yes	7	9
468	5x59	5x60	npy2_on	0	1.29	No	No	No	No	3	4
469	5x33	5x35	npy2_on	0	1.27	No	No	No	No	2	3
470	3x56	I2.E157	npy2_on	0	1.12	Yes	No	No	No	7	4

Orange: nodes, hubs and links specific of npy2_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of npy2_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	npy2_off Avg Int. Strength	npy2_on Avg Int. Strength	npy2_off Num Of Links	npy2_on Num Of Links	ConSurf
1	1x43	npy2_off	2.7125	4.55	4	2	6
2	1x60	npy2_off	4.165	3.76	4	2	5
3	I1x50	npy2_off	4.5275	3.74	4	3	8
4	2x56	npy2_off	4.4525	5.65333	4	3	6
5	E1x49	npy2_off	2.405	8.85	4	2	5
6	3x37	npy2_off	6.5575	3.325	4	2	6
7	3x52	npy2_off	7.52	3.165	4	2	4
8	3x56	npy2_off	5.7525	5.78667	4	3	7
9	4x53	npy2_off	3.8075	3.115	4	2	8
10	E2.Y189	npy2_off	8.07	6.73667	4	3	5
11	E2.P208	npy2_off	5.7375	6.405	4	2	4
12	5x39	npy2_off	7.805	6.40333	4	3	6
13	5x44	npy2_off	3.685	1.39	4	2	5
14	6x37	npy2_off	4.195	5.86	4	1	8
15	6x44	npy2_off	7.01	3.68	4	3	9
16	7x30	npy2_off	6.225	7.71333	4	3	4
17	7x37	npy2_off	5.7175	6.04	4	3	6
18	7x47	npy2_off	7	4.785	4	2	7
19	Lig	Shared	6.51944	13.7529	18	31	0
20	1x39	Shared	6.715	7.02	4	5	7
21	2x42	Shared	4.8025	4.04	4	6	7
22	2x65	Shared	5.5775	3.115	4	4	4
23	E1x50	Shared	6.486	7.746	5	5	8
24	E1x52	Shared	6.295	6.068	4	5	7
25	3x51	Shared	7.8725	6.116	4	5	8
26	4x50	Shared	7.126	4.57	5	6	9
27	4x64	Shared	8.9975	5.872	4	5	5
28	4x65	Shared	6.916	5.3175	5	4	6
29	6x30	Shared	8.0175	6.278	4	5	7
30	6x48	Shared	8.692	3.17	5	6	8
31	6x52	Shared	8.812	2.3575	5	4	7
32	6x54	Shared	8.258	4.754	5	5	4
33	7x38	Shared	9.995	7.852	4	5	5
34	7x53	Shared	6.80167	3.87429	6	7	9
35	8x50	Shared	8.09833	4.19	6	8	8
36	2x40	npy2_on	8.28333	4.3925	3	4	8
37	2x41	npy2_on	9.65	2.595	1	4	5
38	2x46	npy2_on	4.81333	4.708	3	5	9
39	2x50	npy2_on	6.31	5.155	2	4	9
40	2x57	npy2_on	6.38	4.16	2	7	7
41	3x28	npy2_on	3.475	5.224	2	5	5
42	3x32	npy2_on	9.75667	5.8325	3	4	6
43	4x46	npy2_on	10.3	4.4075	2	4	7
44	E2.E188	npy2_on	5.51	7.73	3	4	4
45	E2.W207	npy2_on	14.71	4.872	3	5	5
46	5x51	npy2_on	6.47	2.635	2	4	5
47	5x58	npy2_on	6.28667	3.57889	3	9	9
48	5x65	npy2_on	3.08333	2.5675	3	4	8
49	5x70	npy2_on	0	2.645	0	4	0
50	6x26	npy2_on	4.865	5.762	2	5	4
51	7x52	npy2_on	4.355	3.7525	2	4	8
52	8x54	npy2_on	5.97	5.0175	3	4	6

Orange: nodes, hubs and links specific of npy2_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of npy2_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	npy2_off Recurrence	npy2_on Recurrence	npy2_off Hub1?	npy2_on Hub1?	npy2_off Hub2?	npy2_on Hub2?	ConSurf1	ConSurf2
1	2x60	Lig	npy2_off	17.6759	0.936645	No	No	Yes	Yes	6	0
2	3x32	Lig	npy2_off	11.9294	7.26087	No	Yes	Yes	Yes	6	0
3	3x33	Lig	npy2_off	12.7484	1.17643	No	No	Yes	Yes	4	0
4	3x37	Lig	npy2_off	81.8542	0	Yes	No	Yes	Yes	6	0
5	1x39	2x60	npy2_off	16.105	0	Yes	Yes	No	No	7	6
6	7x35	Lig	npy2_off	11.9294	0	No	No	Yes	Yes	3	0
7	1x42	7x42	npy2_off	12.3456	0	No	No	No	No	7	7
8	1x43	2x57	npy2_off	55.1557	1.19891	Yes	No	No	Yes	6	7
9	1x47	1x48	npy2_off	48.2277	0	No	No	No	No	6	4
10	1x43	1x47	npy2_off	49.275	0	Yes	No	No	No	6	6
11	2x50	7x46	npy2_off	10.768	0	No	Yes	No	No	9	9
12	1x50	2x50	npy2_off	14.3327	8.51973	No	No	No	Yes	9	9
13	1x50	7x50	npy2_off	15.6485	4.91177	No	No	No	No	9	9
14	1x49	7x50	npy2_off	48.2277	3.69413	No	No	No	No	8	9
15	1x48	1x49	npy2_off	48.1606	2.469	No	No	No	No	4	8
16	1x50	2x47	npy2_off	10.4458	0	No	No	No	No	9	9
17	1x53	2x47	npy2_off	15.87	1.3188	No	No	No	No	9	9
18	1x53	7x50	npy2_off	45.2605	0	No	No	No	No	9	9
19	7x53	8x50	npy2_off	37.4731	0	Yes	Yes	Yes	Yes	9	8
20	1x53	7x53	npy2_off	53.0411	0	No	No	Yes	Yes	9	9
21	1x54	2x47	npy2_off	10.4458	0	No	No	No	No	7	9
22	1x60	I1x50	npy2_off	14.0776	0	Yes	No	Yes	No	5	8
23	8x50	I1x50	npy2_off	23.9192	2.1393	Yes	Yes	Yes	No	8	8
24	3x37	4x53	npy2_off	75.2081	0	Yes	No	Yes	No	6	8
25	3x34	4x53	npy2_off	37.8692	7.23465	No	No	Yes	No	5	8
26	3x34	4x50	npy2_off	37.6611	0	No	No	Yes	Yes	5	9
27	2x45	4x50	npy2_off	71.0996	7.40324	No	No	Yes	Yes	9	9
28	2x45	4x46	npy2_off	69.6294	0.251021	No	No	No	Yes	9	7
29	2x38	2x42	npy2_off	24.2213	9.70739	No	No	Yes	Yes	6	7
30	2x38	4x39	npy2_off	12.1509	0	No	No	No	No	6	1
31	3x38	4x53	npy2_off	37.8692	8.41482	No	No	Yes	No	7	8
32	3x38	4x50	npy2_off	37.6611	1.39373	No	No	Yes	Yes	7	9
33	2x42	3x45	npy2_off	39.9033	7.00985	Yes	Yes	No	No	7	7
34	2x46	3x42	npy2_off	10.1772	9.50508	No	Yes	No	No	9	8
35	6x52	Lig	npy2_off	53.4305	0	Yes	Yes	Yes	Yes	7	0
36	3x43	6x44	npy2_off	94.5959	0	No	No	Yes	No	8	9
37	2x56	3x32	npy2_off	12.453	0.955378	Yes	No	No	Yes	6	6
38	4x65	Lig	npy2_off	14.0105	0	Yes	Yes	Yes	Yes	6	0
39	E1x50	Lig	npy2_off	57.1227	0	Yes	Yes	Yes	Yes	8	0
40	E1x50	E1x52	npy2_off	14.4468	8.32865	Yes	Yes	Yes	Yes	8	7
41	E1x50	E2.Y189	npy2_off	40.2591	0	Yes	Yes	Yes	No	8	5
42	E2.V201	E2.Y189	npy2_off	34.2038	4.68323	No	No	Yes	No	4	5
43	E1x49	E2.V201	npy2_off	19.381	1.24386	Yes	No	No	No	5	4
44	3x33	4x57	npy2_off	10.2242	0	No	No	No	No	4	7
45	3x37	4x56	npy2_off	10.3316	2.45401	Yes	No	No	No	6	5
46	3x37	5x461	npy2_off	10.3316	3.67165	Yes	No	No	No	6	6
47	3x43	6x41	npy2_off	93.6224	0	No	No	No	No	8	8
48	5x54	6x41	npy2_off	73.8319	0	No	No	No	No	8	8
49	3x44	5x54	npy2_off	17.7967	0	No	No	No	No	7	8
50	3x45	4x45	npy2_off	37.0368	5.61987	No	No	No	No	7	5
51	3x47	5x54	npy2_off	65.3263	0.0299727	No	No	No	No	9	8
52	3x47	5x58	npy2_off	35.043	1.30756	No	No	No	Yes	9	9
53	5x58	6x37	npy2_off	47.2342	1.34128	No	Yes	Yes	No	9	8
54	6x41	6x42	npy2_off	20.2336	0	No	No	No	No	8	4
55	6x38	6x42	npy2_off	17.3335	0	No	No	No	No	6	4
56	5x58	6x38	npy2_off	16.293	0	No	Yes	No	No	9	6
57	3x47	5x57	npy2_off	60.9291	0.0561987	No	No	No	No	9	7
58	4x41	4x45	npy2_off	34.2844	4.23738	No	No	No	No	5	5
59	4x41	I2.I160	npy2_off	31.532	4.2711	No	No	No	No	5	5
60	3x49	I2.I160	npy2_off	28.7795	0	No	No	No	No	8	5
61	3x49	3x53	npy2_off	26.0271	2.69379	No	No	No	No	8	8
62	5x56	5x57	npy2_off	58.2573	0	No	No	No	No	4	7
63	5x56	5x60	npy2_off	55.5854	0.00374658	No	No	No	No	4	4
64	3x51	5x60	npy2_off	52.9135	2.67881	Yes	Yes	No	No	8	4
65	3x51	3x52	npy2_off	12.1845	0	Yes	Yes	Yes	No	8	4
66	3x51	5x61	npy2_off	31.1627	0	Yes	Yes	No	No	8	8
67	3x53	6x30	npy2_off	23.3754	0	No	No	Yes	Yes	8	7
68	6x30	I2.E157	npy2_off	14.6818	0	Yes	Yes	No	No	7	4
69	6x26	I2.E157	npy2_off	11.7213	0	No	Yes	No	No	4	4
70	4x60	5x39	npy2_off	29.3233	0	No	No	Yes	No	8	6
71	4x60	4x64	npy2_off	24.7986	4.40598	No	No	Yes	Yes	8	5
72	E2.L191	E2.V201	npy2_off	12.9162	2.37159	No	No	No	No	3	4
73	E2.L191	E2.S190	npy2_off	10.3585	0	No	No	No	No	3	1
74	4x64	E2.P208	npy2_off	14.8093	0.0299727	Yes	Yes	Yes	No	5	4
75	5x61	6x34	npy2_off	28.3835	0	No	No	No	No	8	6
76	6x34	6x35	npy2_off	14.6482	0	No	No	No	No	6	6
77	5x62	6x35	npy2_off	11.7414	0	No	No	No	No	5	6
78	5x65	6x34	npy2_off	14.3663	0	No	Yes	No	No	8	6
79	6x36	7x53	npy2_off	17.3872	0	No	No	Yes	Yes	8	9
80	7x34	Lig	npy2_off	58.4452	1.98943	No	No	Yes	Yes	4	0
81	6x54	7x34	npy2_off	55.5183	0	Yes	Yes	No	No	4	4
82	6x54	7x37	npy2_off	20.1732	4.00135	Yes	Yes	Yes	No	4	6
83	6x50	7x37	npy2_off	15.2591	2.64509	No	No	Yes	No	9	6
84	6x50	7x40	npy2_off	10.2242	0	No	No	No	No	9	7
85	6x54	6x58	npy2_off	10.0228	4.0538	Yes	Yes	No	No	4	4
86	6x54	7x30	npy2_off	22.4893	4.10251	Yes	Yes	Yes	No	4	4
87	6x61	E3.V297	npy2_off	10.09	0	No	No	No	No	2	6
88	3x46	6x37	npy2_off	34.3314	0	No	No	Yes	No	9	8
89	6x33	6x37	npy2_off	59.0561	0	No	No	Yes	No	8	8
90	6x33	8x47	npy2_off	56.4984	0	No	No	No	No	8	8
91	6x36	8x47	npy2_off	17.3939	0	No	No	No	No	8	8
92	8x47	8x50	npy2_off	36.4125	3.9414	No	No	Yes	Yes	8	8
93	3x36	Lig	Shared	49.2884	68.7198	No	No	Yes	Yes	7	0
94	1x39	7x38	Shared	19.9181	18.5943	Yes	Yes	Yes	Yes	7	5
95	2x61	2x65	Shared	17.6893	10.8314	No	No	Yes	Yes	6	4
96	1x39	2x61	Shared	22.0798	17.8562	Yes	Yes	No	No	7	6
97	7x38	7x42	Shared	66.2057	12.4049	Yes	Yes	No	No	5	7
98	7x38	Lig	Shared	76.5709	11.5395	Yes	Yes	Yes	Yes	5	0
99	2x57	7x42	Shared	56.6595	13.8549	No	Yes	No	No	7	7
100	2x42	4x46	Shared	68.2666	12.9107	Yes	Yes	No	Yes	7	7
101	3x36	6x48	Shared	48.8185	68.8584	No	No	Yes	Yes	7	8
102	6x44	6x48	Shared	100	15.0313	Yes	No	Yes	Yes	9	8
103	6x48	6x52	Shared	55.5384	14.9189	Yes	Yes	Yes	Yes	8	7
104	5x39	Lig	Shared	31.25	13.3828	Yes	No	Yes	Yes	6	0
105	6x40	7x53	Shared	12.6611	69.4054	No	No	Yes	Yes	8	9
106	6x40	7x52	Shared	10.2242	98.6587	No	No	No	Yes	8	8
107	2x42	3x46	Shared	35.4055	31.5013	Yes	Yes	No	No	7	9
108	2x46	7x53	npy2_on	0	30.3735	No	Yes	Yes	Yes	9	9
109	6x43	7x52	npy2_on	0	99.5579	No	No	No	Yes	6	8
110	6x43	6x47	npy2_on	5.13561	100	No	No	No	No	6	8
111	6x47	7x45	npy2_on	0	95.6427	No	No	No	No	8	9
112	6x48	7x45	npy2_on	2.18179	95.8113	Yes	Yes	No	No	8	9
113	1x52	8x54	npy2_on	4.1152	10.3368	No	No	No	Yes	7	6
114	8x50	8x54	npy2_on	8.1834	14.0085	Yes	Yes	No	Yes	8	6
115	2x43	8x50	npy2_on	0.926423	33.6106	No	No	Yes	Yes	8	8
116	2x43	7x53	npy2_on	1.08754	34.6072	No	No	Yes	Yes	8	9
117	4x46	4x50	npy2_on	0	10.2207	No	Yes	Yes	Yes	7	9
118	3x46	7x53	npy2_on	0	28.4515	No	No	Yes	Yes	9	9
119	2x46	3x39	npy2_on	6.49839	10.3743	No	Yes	No	No	9	9
120	2x63	E1x50	npy2_on	0.516917	16.6273	No	No	Yes	Yes	5	8
121	2x63	Lig	npy2_on	6.43126	18.3845	No	No	Yes	Yes	5	0
122	E2x52	Lig	npy2_on	0	17.2605	No	No	Yes	Yes	4	0
123	5x58	6x40	npy2_on	0	28.9611	No	Yes	No	No	9	8
124	5x57	5x58	npy2_on	0	10.5167	No	No	No	Yes	7	9
125	5x58	5x61	npy2_on	0	30.913	No	Yes	No	No	9	8
126	4x64	E2.W207	npy2_on	5.05505	19.6208	Yes	Yes	No	Yes	5	5
127	E2.W207	E2x52	npy2_on	0	13.5476	No	Yes	No	No	5	4
128	5x39	E2.W207	npy2_on	0	12.5585	Yes	No	No	Yes	6	5
129	6x58	Lig	npy2_on	0	10.6178	No	No	Yes	Yes	4	0
130	5x61	5x65	npy2_on	0	25.0909	No	No	No	Yes	8	8
131	5x65	6x30	npy2_on	5.6391	10.0446	No	Yes	Yes	Yes	8	7
132	5x65	6x26	npy2_on	0	12.7122	No	Yes	No	Yes	8	4
133	6x48	7x42	npy2_on	0	26.2823	Yes	Yes	No	No	8	7
134	1x39	2x57	npy2_on	0	11.5245	Yes	Yes	No	Yes	7	7
135	5x58	7x53	npy2_on	0	12.8957	No	Yes	Yes	Yes	9	9

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
2x60	Lig	Shared	9.97	12.07	0	1	1	0
2x63	Lig	Shared	3.6	21.26	1	1	1	0
E1x50	Lig	npy2_off	4.2	0	1	1	1	0
3x32	Lig	Shared	11.46	5.62	1	1	1	0
3x33	Lig	Shared	4.21	2.89	0	1	1	0
3x36	Lig	Shared	8.25	3.78	0	1	1	0
3x37	Lig	npy2_off	3.27	0	0	0	1	0
4x61	Lig	Shared	5.96	3.55	1	1	1	0
4x65	Lig	npy2_off	8.22	0	0	0	1	0
5x39	Lig	Shared	3.6	10.25	1	1	1	0
5x40	Lig	Shared	4.62	5.27	0	1	1	0
5x43	Lig	npy2_off	3.69	0	1	0	1	0
5x44	Lig	npy2_off	3.41	0	1	0	1	0
6x52	Lig	npy2_off	11.07	0	1	0	1	0
6x55	Lig	Shared	12.28	9.34	1	1	1	0
7x34	Lig	Shared	8.24	7.77	0	1	1	0
7x38	Lig	Shared	9.49	7.61	1	1	1	0
1x39	2x60	npy2_off	3.75	0	0	1	2	1
1x39	7x38	Shared	8.71	7.62	0	1	2	1
2x53	2x56	Shared	3.42	5.12	0	0	2	1
2x56	3x28	npy2_off	3.42	0	0	1	1	2
2x56	3x32	Shared	9.16	9.16	0	1	1	1
2x57	7x42	Shared	8.48	7.07	0	1	2	2
2x63	E1x50	Shared	8.68	9.65	1	1	1	1
2x64	2x65	npy2_off	2.95	0	0	0	1	2
E1x50	E1x52	Shared	10.47	15.12	1	1	1	2
3x25	E1x50	Shared	5.22	5.22	1	1	2	1
E1x50	E2.Y189	npy2_off	3.86	0	1	1	1	2
3x25	E2.Y189	npy2_off	4.03	0	1	1	2	2
3x25	E2x50	Shared	7.28	7.28	1	1	2	2
3x26	4x65	Shared	3.39	1.13	0	0	2	1
3x28	3x29	Shared	3.53	3.53	0	0	2	2
3x29	4x65	Shared	12.97	11.53	0	0	2	1
3x32	7x38	npy2_off	8.65	0	1	1	1	1
3x36	6x48	Shared	6.13	2.45	0	1	1	2
3x37	4x53	npy2_off	4.33	0	0	0	1	2
3x37	4x56	Shared	3.99	1.33	0	0	1	2
3x37	5x461	Shared	14.64	5.32	0	0	1	2
4x60	5x39	npy2_off	15.3	0	0	0	2	1
4x61	5x39	Shared	4.69	7.03	1	1	1	1
4x65	E2x50	npy2_off	4.18	0	0	0	1	2
4x65	E2x52	Shared	5.82	5.82	0	0	1	1
E2.E188	E2x51	Shared	5.64	7.06	0	1	1	1
E2.E188	E2.K206	Shared	9.45	9.45	0	1	1	2
E2.E193	E2.I200	npy2_off	5.47	0	0	0	1	1
5x39	5x43	npy2_off	7.63	0	1	1	1	1
5x40	6x59	Shared	7.36	4.42	0	1	1	1
5x44	5x47	npy2_off	3.52	0	1	0	1	2
5x44	6x52	Shared	6.43	1.29	1	0	1	1
5x47	6x52	Shared	9.8	2.18	1	0	2	1
6x48	6x52	Shared	10.58	3.17	1	0	2	1
6x51	6x55	npy2_off	7.99	0	0	0	2	1
6x51	7x34	Shared	7.31	2.44	0	0	2	1
6x52	6x55	npy2_off	6.18	0	1	0	1	1
6x54	6x58	Shared	11.8	2.62	6	1	2	1
6x54	7x30	Shared	9.28	6.19	6	1	2	1
6x54	7x34	npy2_off	7.5	0	6	1	2	1
6x58	E3.V297	Shared	3.21	3.21	0	1	1	2
7x30	E3.V297	npy2_off	6.31	0	0	1	1	2
7x26	7x30	npy2_off	3.45	0	0	0	2	1
7x27	7x30	npy2_off	5.86	0	0	0	2	1
7x32	7x35	npy2_off	4.42	0	0	0	2	1
7x38	7x42	Shared	13.13	10.51	1	1	1	2
E2.I194	E2.I200	npy2_off	2.94	0	0	1	1	1
7x27	E3.L298	npy2_off	2.77	0	0	0	2	1
E2.E211	E2.K212	npy2_off	2.7	0	0	0	1	2
7x26	7x29	npy2_off	2.6	0	0	0	2	2
3x33	4x57	npy2_off	1.95	0	0	1	1	2
7x35	Lig	npy2_off	1.81	0	0	0	1	0
2x56	3x31	npy2_off	1.81	0	0	1	1	2
E2.A202	E2.I192	npy2_off	1.62	0	0	0	2	1
E2.E188	E2.S190	Shared	1.44	4.31	0	1	1	2
5x44	6x56	npy2_off	1.38	0	1	0	1	2
E1x49	E2.I200	npy2_off	1.37	0	0	0	2	1
7x28	7x29	Shared	1.35	4.05	0	1	1	2
2x63	E2.A202	Shared	1.33	4	1	1	1	2
E2.E188	Lig	npy2_on	0	10.1	0	1	1	0
E2.I192	Lig	npy2_on	0	6.05	0	1	1	0
E2x51	Lig	npy2_on	0	4.29	0	1	1	0
E2.E211	Lig	npy2_on	0	3.14	0	0	1	0
E2.E193	Lig	npy2_on	0	6.75	0	0	1	0
Lig	NT.L40	npy2_on	0	9.56	1	1	0	1
E2.I194	Lig	npy2_on	0	9.68	0	1	1	0
7x28	Lig	npy2_on	0	3.71	0	1	1	0
E3.L298	Lig	npy2_on	0	15.9	0	1	1	0
E2.I200	Lig	npy2_on	0	2.94	0	1	1	0
7x31	Lig	npy2_on	0	7.15	0	0	1	0
7x30	Lig	npy2_on	0	12.26	0	1	1	0
E2x52	Lig	npy2_on	0	12.79	0	1	1	0
6x58	Lig	npy2_on	0	5.23	0	1	1	0
6x59	Lig	npy2_on	0	5.96	0	1	1	0
2x64	Lig	npy2_on	0	4.25	0	0	1	0
2x56	Lig	npy2_on	0	2.68	0	1	1	0
1x35	7x35	npy2_on	0	5.9	0	0	2	1
1x39	2x57	npy2_on	0	3.52	0	1	2	2
1x39	7x35	npy2_on	0	4.99	0	1	2	1
2x57	7x38	npy2_on	0	2.57	0	1	2	1
2x60	3x32	npy2_on	0	4.25	0	1	1	1
2x60	7x38	npy2_on	0	10.95	0	1	1	1
3x28	E1x50	npy2_on	0	6.13	0	0	2	1
E1x50	E2x50	npy2_on	0	2.61	1	1	1	2
3x25	4x65	npy2_on	0	2.79	1	1	2	1
3x28	3x32	npy2_on	0	4.3	0	0	2	1
3x33	4x61	npy2_on	0	1.71	0	1	1	1
E2.Y189	E2x50	npy2_on	0	4.03	1	0	2	2
E2.I192	E2.S190	npy2_on	0	4.64	0	1	1	2
E2.F198	E2.I194	npy2_on	0	6.28	0	0	2	1
E2.F198	E2.I200	npy2_on	0	6.28	0	0	2	1
E2.W207	E2x52	npy2_on	0	3.27	5	1	2	1
5x39	E2.W207	npy2_on	0	1.93	1	1	1	2
5x37	6x59	npy2_on	0	2.89	0	0	2	1
5x43	5x461	npy2_on	0	4.5	1	0	1	2
5x43	6x52	npy2_on	0	2.79	1	0	1	1
6x48	7x42	npy2_on	0	2.33	1	0	2	2
6x54	E3.V297	npy2_on	0	2.62	6	1	2	2
6x55	7x34	npy2_on	0	2.34	1	1	1	1
7x30	E3.L298	npy2_on	0	4.69	0	1	1	1
7x26	7x27	npy2_on	0	2.71	0	0	2	2
7x29	7x32	npy2_on	0	6.63	0	0	2	2
5x44	5x48	npy2_on	0	1.49	1	0	1	2
7x27	E3.V297	npy2_on	0	1.49	0	0	2	2
E3.S295	Lig	npy2_on	0	1.39	0	0	1	0
7x28	NT.D42	npy2_on	0	1.38	0	1	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	npy2_off	7DDZ-Y₂-JNJ-31020028
	npy2_on	7YOO-Y₂-Neuropeptide-Y-Gi1/β1/γ2

Network Difference
Value	npy2_off	npy2_on
I_min	2.95	1.71
Number of Linked Nodes	270	280
Number of Specific Nodes	14 (5.19%)	24 (8.57%)
Number of Shared Nodes	256 (94.81%)	256 (91.43%)
Number of Links	298	332
Number of Specific Links	138 (46.31%)	172 (51.81%)
Number of Shared Links	160 (53.69%)	160 (48.19%)
Number of Hubs	35	34
Number of Specific Hubs	18 (51.43%)	17 (50.00%)
Number of Shared Hubs	17 (48.57%)	17 (50.00%)
Average % Shared Neighbours (Jaccard)	36.18
Average % Shared Neighbours (Otsuka)	45.60
Average % Shared Neighbours (Overlap Coefficient)	54.74
Average % Shared Cliques (k3-6)	76.60
Graphlets Similarity	0.595035

Paths Difference
Value	npy2_off	npy2_on
Number Of Nodes in MetaPath	102	40
Specific Nodes in MetaPath	72 (70.59%)	10 (25.00%)
Shared Nodes in MetaPath	256 (94.81%)	256 (94.81%)
Number Of Links MetaPath	107	43
Specific Links in MetaPath	92 (85.98%)	28 (65.12%)
Shared Links in MetaPath	160 (53.69%)	160 (53.69%)
Number of Shortest Paths	55205	52931
Length Of Smallest Path	3	3
Average Path Length	12.7589	11.8555
Length of Longest Path	27	25
Minimum Path Strength	1.32	1.19
Average Path Strength	6.1897	4.62692
Maximum Path Strength	19.365	15.6033
Minimum Path Correlation	0.7	0.7
Average Path Correlation	0.92526	0.940093
Maximum Path Correlation	0.99	0.99
Minimum % Of Corr. Nodes	4.16667	6.25
Average % Of Corr. Nodes	51.1476	62.8494
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	38.5273	39.001
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

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