Orange: nodes, hubs and links specific of npy2_on_gp network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of npy2_off network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.


Index Hub Owner npy2_on_gp Avg Int. Strength npy2_off Avg Int. Strength npy2_on_gp Num Of Links npy2_off Num Of Links ConSurf
1G.HN.37 npy2_on_gp1.51250403
2G.HN.43 npy2_on_gp2.90750409
3G.HN.44 npy2_on_gp4.52250406
4G.S1.02 npy2_on_gp5.3180505
5G.S1.05 npy2_on_gp4.4050409
6G.S1.06 npy2_on_gp3.920508
7G.S1.07 npy2_on_gp4.480409
8G.s1h1.01 npy2_on_gp2.3150409
9G.H1.01 npy2_on_gp3.6440509
10G.S2.08 npy2_on_gp6.0650405
11G.S3.01 npy2_on_gp3.8750404
12G.S3.06 npy2_on_gp4.346670605
13G.S3.07 npy2_on_gp4.20409
14G.S3.08 npy2_on_gp3.4150409
15G.s3h2.03 npy2_on_gp9.8750409
16G.H2.02 npy2_on_gp3.64750408
17G.H2.06 npy2_on_gp5.0120509
18G.H2.07 npy2_on_gp6.890709
19G.H2.08 npy2_on_gp2.928330608
20G.H2.09 npy2_on_gp5.28750408
21G.H2.10 npy2_on_gp3.160407
22G.h2s4.01 npy2_on_gp5.781670609
23G.S4.02 npy2_on_gp4.49250408
24G.S4.04 npy2_on_gp4.4320509
25G.S4.05 npy2_on_gp3.2080507
26G.S4.06 npy2_on_gp2.86250407
27G.s4h3.04 npy2_on_gp5.041670608
28G.H3.09 npy2_on_gp5.182860709
29G.H3.15 npy2_on_gp3.510408
30G.H3.17 npy2_on_gp5.3550805
31G.H3.18 npy2_on_gp4.4220509
32G.h3s5.03 npy2_on_gp3.550407
33G.S5.03 npy2_on_gp2.47250408
34G.S5.05 npy2_on_gp3.140609
35G.S5.06 npy2_on_gp3.67250408
36G.HG.04 npy2_on_gp9.30750409
37G.HG.07 npy2_on_gp3.08250409
38G.hgh4.02 npy2_on_gp6.601670607
39G.hgh4.05 npy2_on_gp6.7460507
40G.H4.10 npy2_on_gp7.170406
41G.H4.15 npy2_on_gp3.81250408
42G.S6.02 npy2_on_gp4.694290707
43G.H5.06 npy2_on_gp4.8520503
44G.H5.08 npy2_on_gp3.7750408
45G.H5.13 npy2_on_gp8.1380508
46G.H5.26 npy2_on_gp5.660605
47b.1x18 npy2_on_gp5.33250406
48b.h2x1 npy2_on_gp3.930405
49b.lhb1x6 npy2_on_gp3.81750403
50b.lhb1x9 npy2_on_gp3.7650403
51b.lhb1x11 npy2_on_gp3.78750404
52b.b1x3 npy2_on_gp4.5640507
53b.b1x4 npy2_on_gp3.30407
54b.b1x6 npy2_on_gp8.460409
55b.l1x3 npy2_on_gp7.1760509
56b.b2x1 npy2_on_gp6.780508
57b.b2x3 npy2_on_gp3.2950406
58b.b2x5 npy2_on_gp5.493330607
59b.b3x2 npy2_on_gp4.65750405
60b.b4x3 npy2_on_gp2.9950407
61b.b4x6 npy2_on_gp8.254290709
62b.b5x3 npy2_on_gp5.385710709
63b.b5x5 npy2_on_gp5.60250405
64b.b5x7 npy2_on_gp3.92250407
65b.l5x1 npy2_on_gp4.230408
66b.l5x5 npy2_on_gp5.151250809
67b.b6x3 npy2_on_gp2.97750408
68b.b6x5 npy2_on_gp3.9420506
69b.b7x1 npy2_on_gp7.23750404
70b.b7x2 npy2_on_gp3.440408
71b.b7x3 npy2_on_gp2.39250409
72b.b7x4 npy2_on_gp3.1450408
73b.l7x2 npy2_on_gp3.418570709
74b.b8x3 npy2_on_gp3.85750406
75b.b8x4 npy2_on_gp5.20606
76b.l8x10 npy2_on_gp3.76250404
77b.b9x3 npy2_on_gp4.320406
78b.l9x3 npy2_on_gp6.0050609
79b.l9x5 npy2_on_gp1.88250408
80b.l9x6 npy2_on_gp4.208890908
81b.b10x5 npy2_on_gp4.13250409
82b.l10x1 npy2_on_gp3.51750403
83b.b11x4 npy2_on_gp5.1150409
84b.b11x6 npy2_on_gp6.720409
85b.l11x1 npy2_on_gp3.0760509
86b.l11x2 npy2_on_gp7.43750409
87b.b12x6 npy2_on_gp7.6350608
88b.b13x5 npy2_on_gp3.60404
89b.b13x7 npy2_on_gp7.0080507
90b.l13x3 npy2_on_gp6.868330609
91b.l13x6 npy2_on_gp3.12750409
92b.b15x1 npy2_on_gp6.8520509
93b.l15x1 npy2_on_gp3.2420507
94b.l15x2 npy2_on_gp4.950409
95b.b16x4 npy2_on_gp7.0280506
96b.b16x5 npy2_on_gp3.230505
97b.b16x6 npy2_on_gp7.996670608
98b.b16x7 npy2_on_gp4.48250409
99b.b17x4 npy2_on_gp4.24750405
100b.b17x7 npy2_on_gp7.63750408
101b.l17x3 npy2_on_gp7.217140709
102b.l17x6 npy2_on_gp6.56250409
103b.l17x7 npy2_on_gp3.8480507
104b.b18x3 npy2_on_gp3.4750408
105b.b18x5 npy2_on_gp3.330505
106b.l18x1 npy2_on_gp4.528570706
107b.b19x2 npy2_on_gp6.2940506
108b.b19x4 npy2_on_gp5.2360508
109b.b19x6 npy2_on_gp5.83750409
110b.l19x1 npy2_on_gp6.0750409
111b.l19x2 npy2_on_gp7.60409
112b.b20x2 npy2_on_gp4.37750406
113b.b20x4 npy2_on_gp7.60608
114b.b20x6 npy2_on_gp7.003330606
115b.b21x2 npy2_on_gp3.94250406
116b.b21x4 npy2_on_gp3.490405
117b.b21x5 npy2_on_gp6.1650404
118b.b21x7 npy2_on_gp4.987140705
119b.l21x5 npy2_on_gp4.5920504
120b.l21x9 npy2_on_gp4.6240506
121b.b22x1 npy2_on_gp3.0250408
122b.b22x5 npy2_on_gp5.44250407
123b.b23x6 npy2_on_gp6.4880507
124b.b24x4 npy2_on_gp6.2340506
125b.b24x5 npy2_on_gp3.440405
126b.b24x6 npy2_on_gp4.1040508
127b.b25x3 npy2_on_gp5.746670605
128b.b25x7 npy2_on_gp5.980407
129b.l25x3 npy2_on_gp8.57250409
130b.l25x6 npy2_on_gp9.1150408
131b.l26x1 npy2_on_gp5.79250407
132b.l26x5 npy2_on_gp4.23250405
133b.l27x1 npy2_on_gp8.612860709
134b.b28x3 npy2_on_gp5.15750407
135b.b28x4 npy2_on_gp4.3880506
136b.b28x6 npy2_on_gp6.370509
137b.b28x7 npy2_on_gp3.220409
138g.h2x11 npy2_on_gp7.6750406
139g.ctx3 npy2_on_gp5.230509
140g.ctx6 npy2_on_gp3.0740506
141g.ctx9 npy2_on_gp4.2050406
142g.ctx16 npy2_on_gp3.473750808
1432x40 npy2_on_gp4.39258.28333438
1442x46 npy2_on_gp4.7084.81333539
1452x50 npy2_on_gp5.1556.31429
1462x57 npy2_on_gp4.166.38727
1473x28 npy2_on_gp5.2243.475525
1483x32 npy2_on_gp5.83259.75667436
1493x50 npy2_on_gp3.2826.79667539
150I2.H155 npy2_on_gp4.1960508
1514x46 npy2_on_gp4.407510.3427
152E2.E188 npy2_on_gp7.735.51434
153E2.W207 npy2_on_gp4.87214.71535
1545x51 npy2_on_gp2.6356.47425
1555x58 npy2_on_gp3.578896.28667939
1565x70 npy2_on_gp3.8580504
1575x71 npy2_on_gp4.620504
1586x26 npy2_on_gp5.494.865624
1597x52 npy2_on_gp3.75254.355428
1608x47 npy2_on_gp4.20257.65333438
1618x48 npy2_on_gp3.455.695425
1628x54 npy2_on_gp5.01755.97436
163Lig Shared13.75296.5194431180
1641x39 Shared7.026.715547
1652x42 Shared4.044.8025647
1662x65 Shared3.1155.5775444
167E1x50 Shared7.7466.486558
168E1x52 Shared6.0686.295547
1693x51 Shared6.1167.8725548
1704x50 Shared4.577.126659
1714x64 Shared5.8728.9975545
1724x65 Shared5.31756.916456
1736x30 Shared6.2788.0175547
1746x48 Shared3.178.692658
1756x52 Shared2.35758.812457
1766x54 Shared4.7548.258554
1777x38 Shared7.8529.995545
1787x53 Shared3.874296.80167769
1798x50 Shared4.198.09833868
1801x43 npy2_off4.552.7125246
1811x60 npy2_off3.764.165245
182I1x50 npy2_off3.744.5275348
1832x56 npy2_off5.653334.4525346
184E1x49 npy2_off8.852.405245
1853x37 npy2_off3.3256.5575246
1863x52 npy2_off3.1657.52244
1873x56 npy2_off5.786675.7525347
1884x53 npy2_off3.1153.8075248
189E2.Y189 npy2_off6.736678.07345
190E2.P208 npy2_off6.4055.7375244
1915x39 npy2_off6.403337.805346
1925x44 npy2_off1.393.685245
1936x37 npy2_off5.864.195148
1946x44 npy2_off3.687.01349
1957x30 npy2_off7.713336.225344
1967x37 npy2_off6.045.7175346
1977x47 npy2_off4.7857247
   
Orange: nodes, hubs and links specific of npy2_on_gp network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of npy2_off network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Owner npy2_on_gp Recurrence npy2_off Recurrence npy2_on_gp Hub1? npy2_off Hub1? npy2_on_gp Hub2? npy2_off Hub2? ConSurf1 ConSurf2
1b.b2x3 b.b3x2 npy2_on_gp11.39550YesNoYesNo65
2b.b26x2 b.b2x3 npy2_on_gp18.71540NoNoYesNo76
3b.b26x1 b.b26x2 npy2_on_gp19.10670NoNoNoNo97
4b.b26x1 b.l27x1 npy2_on_gp19.30340NoNoYesNo99
5G.H3.17 b.l27x1 npy2_on_gp17.71870YesNoYesNo59
6G.H2.08 G.H3.17 npy2_on_gp54.37310YesNoYesNo85
7G.H2.07 G.H2.08 npy2_on_gp52.81710YesNoYesNo98
8G.H2.07 G.s3h2.03 npy2_on_gp21.83810YesNoYesNo99
9G.H2.02 G.s3h2.03 npy2_on_gp23.52670YesNoYesNo89
10G.H2.02 b.l9x5 npy2_on_gp57.14210YesNoYesNo88
11b.l7x4 b.l9x5 npy2_on_gp1000NoNoYesNo98
12G.hfs2.07 b.l7x4 npy2_on_gp99.91490NoNoNoNo99
13G.hfs2.06 G.hfs2.07 npy2_on_gp99.82960NoNoNoNo79
14G.S2.02 G.hfs2.06 npy2_on_gp99.74420NoNoNoNo57
15G.S2.02 G.S3.07 npy2_on_gp99.65870NoNoYesNo59
16G.S1.06 G.S3.07 npy2_on_gp54.88450YesNoYesNo89
17G.S1.06 G.S4.03 npy2_on_gp52.57010YesNoNoNo87
18G.H2.07 b.l9x6 npy2_on_gp49.12720YesNoYesNo98
19G.H2.02 b.l9x6 npy2_on_gp33.64480YesNoYesNo88
20b.l11x1 b.l9x6 npy2_on_gp35.95260YesNoYesNo98
21b.l11x1 b.l9x5 npy2_on_gp39.960YesNoYesNo98
22G.H1.01 G.S3.07 npy2_on_gp44.5160YesNoYesNo99
23G.H2.04 G.H3.08 npy2_on_gp19.31620NoNoNoNo99
24G.H3.08 G.S4.04 npy2_on_gp19.13090NoNoYesNo99
25G.H1.01 G.S4.05 npy2_on_gp43.54510YesNoYesNo97
26G.S4.04 G.S4.06 npy2_on_gp14.24570YesNoYesNo97
27G.S4.03 G.S5.05 npy2_on_gp42.80680NoNoYesNo79
28G.S4.05 G.S5.05 npy2_on_gp42.99480YesNoYesNo79
29G.H2.06 b.l9x6 npy2_on_gp14.82060YesNoYesNo98
30G.H2.06 b.l17x6 npy2_on_gp14.35920YesNoYesNo99
31G.H5.06 G.S5.05 npy2_on_gp83.56920YesNoYesNo39
325x71 G.H5.06 npy2_on_gp78.72010YesNoYesNo43
335x70 5x71 npy2_on_gp77.12020YesNoYesNo44
345x70 6x26 npy2_on_gp75.320YesNoYesNo44
355x61 5x65 npy2_on_gp63.42680NoNoNoNo88
365x65 6x26 npy2_on_gp63.51170NoNoYesNo84
37b.l17x6 b.l19x1 npy2_on_gp20.18750YesNoYesNo99
38b.l19x1 b.l19x2 npy2_on_gp19.86340YesNoYesNo99
39b.b19x6 b.l19x2 npy2_on_gp12.53860YesNoYesNo99
40b.l23x1 b.l25x6 npy2_on_gp30.28610NoNoYesNo68
41b.l21x7 b.l23x1 npy2_on_gp31.36590NoNoNoNo56
42b.l21x7 b.l23x2 npy2_on_gp31.18330NoNoNoNo58
43b.l21x5 b.l23x2 npy2_on_gp21.19480YesNoNoNo48
44b.b23x6 b.l21x5 npy2_on_gp10.41660YesNoYesNo74
45b.b21x7 b.b24x6 npy2_on_gp27.1910YesNoYesNo58
46b.b21x7 b.b23x2 npy2_on_gp10.3330YesNoNoNo56
47b.b22x1 b.l25x6 npy2_on_gp12.95090YesNoYesNo88
48b.b22x1 b.b23x5 npy2_on_gp11.10980YesNoNoNo87
495x58 5x61 npy2_on_gp62.99960YesNoNoNo98
505x58 6x40 npy2_on_gp55.43780YesNoNoNo98
516x43 7x52 npy2_on_gp55.8090NoNoYesNo68
526x43 6x47 npy2_on_gp55.26665.13561NoNoNoNo68
536x47 7x45 npy2_on_gp52.16970NoNoNoNo89
546x48 7x45 npy2_on_gp51.89652.18179YesYesNoNo89
556x48 7x42 npy2_on_gp11.71110YesYesNoNo87
56G.H2.04 G.H2.07 npy2_on_gp17.08210NoNoYesNo99
57G.H3.17 b.l25x6 npy2_on_gp39.97880YesNoYesNo58
586x40 7x52 Shared56.892310.2242NoNoYesNo88
593x36 6x48 Shared31.65348.8185NoNoYesYes78
603x36 Lig Shared31.378149.2884NoNoYesYes70
612x60 Lig npy2_off0.2924817.6759NoNoYesYes60
623x32 Lig npy2_off2.0459811.9294YesNoYesYes60
633x33 Lig npy2_off0.29467812.7484NoNoYesYes40
643x37 Lig npy2_off081.8542NoYesYesYes60
651x39 2x60 npy2_off016.105YesYesNoNo76
661x39 7x38 npy2_off4.9849119.9181YesYesYesYes75
677x35 Lig npy2_off011.9294NoNoYesYes30
682x61 2x65 npy2_off3.4803117.6893NoNoYesYes64
691x39 2x61 npy2_off5.7972322.0798YesYesNoNo76
701x42 7x42 npy2_off012.3456NoNoNoNo77
717x38 7x42 npy2_off5.4309766.2057YesYesNoNo57
727x38 Lig npy2_off0.19232976.5709YesYesYesYes50
731x43 2x57 npy2_off0.29499255.1557NoYesYesNo67
742x57 7x42 npy2_off6.0050756.6595YesNoNoNo77
751x47 1x48 npy2_off048.2277NoNoNoNo64
761x43 1x47 npy2_off049.275NoYesNoNo66
772x50 7x46 npy2_off010.768YesNoNoNo99
781x50 2x50 npy2_off2.9698814.3327NoNoYesNo99
791x50 7x50 npy2_off1.697815.6485NoNoNoNo99
801x49 7x50 npy2_off1.2735348.2277NoNoNoNo89
811x48 1x49 npy2_off0.84912248.1606NoNoNoNo48
821x50 2x47 npy2_off010.4458NoNoNoNo99
831x53 2x47 npy2_off0.29461515.87NoNoNoNo99
841x53 7x50 npy2_off045.2605NoNoNoNo99
857x53 8x50 npy2_off037.4731YesYesYesYes98
861x53 7x53 npy2_off053.0411NoNoYesYes99
871x54 2x47 npy2_off010.4458NoNoNoNo79
881x60 I1x50 npy2_off014.0776NoYesNoYes58
898x50 I1x50 npy2_off0.57773923.9192YesYesNoYes88
903x37 4x53 npy2_off075.2081NoYesNoYes68
913x34 4x53 npy2_off1.1584337.8692NoNoNoYes58
923x34 4x50 npy2_off037.6611NoNoYesYes59
932x45 4x50 npy2_off0.32444171.0996NoNoYesYes99
942x45 4x46 npy2_off0.1397169.6294NoNoYesNo97
952x42 4x46 npy2_off3.2349368.2666YesYesYesNo77
962x38 2x42 npy2_off1.2124924.2213NoNoYesYes67
972x38 4x39 npy2_off012.1509NoNoNoNo61
983x38 4x53 npy2_off1.3510737.8692NoNoNoYes78
993x38 4x50 npy2_off1.7359837.6611NoNoYesYes79
1002x42 3x45 npy2_off0.86626439.9033YesYesNoNo77
1016x44 6x48 npy2_off3.8234100NoYesYesYes98
1022x46 3x42 npy2_off1.1684110.1772YesNoNoNo98
1036x52 Lig npy2_off053.4305YesYesYesYes70
1046x48 6x52 npy2_off4.0986155.5384YesYesYesYes87
1053x43 6x44 npy2_off094.5959NoNoNoYes89
1062x56 3x32 npy2_off0.016011712.453NoYesYesNo66
1074x65 Lig npy2_off014.0105YesYesYesYes60
108E1x50 Lig npy2_off057.1227YesYesYesYes80
109E1x50 E1x52 npy2_off2.0638714.4468YesYesYesYes87
110E1x50 E2.Y189 npy2_off040.2591YesYesNoYes85
111E2.V201 E2.Y189 npy2_off1.1780834.2038NoNoNoYes45
112E1x49 E2.V201 npy2_off0.29574519.381NoYesNoNo54
1133x33 4x57 npy2_off010.2242NoNoNoNo47
1143x37 4x56 npy2_off0.59092510.3316NoYesNoNo65
1153x37 5x461 npy2_off0.88623110.3316NoYesNoNo66
1163x43 6x41 npy2_off093.6224NoNoNoNo88
1175x54 6x41 npy2_off073.8319NoNoNoNo88
1183x44 5x54 npy2_off017.7967NoNoNoNo78
1193x45 4x45 npy2_off0.69321237.0368NoNoNoNo75
1203x47 5x54 npy2_off065.3263NoNoNoNo98
1213x47 5x58 npy2_off0.29543135.043NoNoYesNo99
1225x58 6x37 npy2_off0.29549447.2342YesNoNoYes98
1236x41 6x42 npy2_off020.2336NoNoNoNo84
1246x38 6x42 npy2_off017.3335NoNoNoNo64
1255x58 6x38 npy2_off016.293YesNoNoNo96
1263x47 5x57 npy2_off060.9291NoNoNoNo97
1274x41 4x45 npy2_off0.52028634.2844NoNoNoNo55
1284x41 I2.I160 npy2_off0.52085131.532NoNoNoNo55
1293x49 I2.I160 npy2_off028.7795NoNoNoNo85
1303x49 3x53 npy2_off026.0271NoNoNoNo88
1315x56 5x57 npy2_off058.2573NoNoNoNo47
1325x56 5x60 npy2_off6.27909e-0555.5854NoNoNoNo44
1333x51 5x60 npy2_off0.590852.9135YesYesNoNo84
1343x51 3x52 npy2_off012.1845YesYesNoYes84
1353x51 5x61 npy2_off031.1627YesYesNoNo88
1363x53 6x30 npy2_off023.3754NoNoYesYes87
1376x30 I2.E157 npy2_off014.6818YesYesNoNo74
1386x26 I2.E157 npy2_off011.7213YesNoNoNo44
1395x39 Lig npy2_off3.7998631.25NoYesYesYes60
1404x60 5x39 npy2_off029.3233NoNoNoYes86
1414x60 4x64 npy2_off1.1733124.7986NoNoYesYes85
142E2.L191 E2.V201 npy2_off0.58954412.9162NoNoNoNo34
143E2.L191 E2.S190 npy2_off010.3585NoNoNoNo31
1444x64 E2.P208 npy2_off0.00050232714.8093YesYesNoYes54
1455x61 6x34 npy2_off028.3835NoNoNoNo86
1466x34 6x35 npy2_off014.6482NoNoNoNo66
1475x62 6x35 npy2_off011.7414NoNoNoNo56
1485x65 6x34 npy2_off014.3663NoNoNoNo86
1496x36 7x53 npy2_off017.3872NoNoYesYes89
1506x40 7x53 npy2_off1.7249312.6611NoNoYesYes89
1517x34 Lig npy2_off0.30698558.4452NoNoYesYes40
1526x54 7x34 npy2_off055.5183YesYesNoNo44
1536x54 7x37 npy2_off0.61685820.1732YesYesNoYes46
1546x50 7x37 npy2_off0.31922915.2591NoNoNoYes96
1556x50 7x40 npy2_off010.2242NoNoNoNo97
1566x54 6x58 npy2_off0.89263610.0228YesYesNoNo44
1576x54 7x30 npy2_off0.89357822.4893YesYesNoYes44
1586x61 E3.V297 npy2_off010.09NoNoNoNo26
1593x46 6x37 npy2_off034.3314NoNoNoYes98
1602x42 3x46 npy2_off5.7552335.4055YesYesNoNo79
1616x33 6x37 npy2_off059.0561NoNoNoYes88
1626x33 8x47 npy2_off056.4984NoNoYesNo88
1636x36 8x47 npy2_off017.3939NoNoYesNo88
1648x47 8x50 npy2_off6.603636.4125YesNoYesYes88

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Midway



Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Node1Node2OwnerNet1LinkStrengthNet2LinkStrengthComm1Comm2Node1ShellNode2Shell
2x60LigShared9.9712.070210
2x63LigShared3.621.261210
E1x50Lignpy2_off4.201210
3x32LigShared11.465.621210
3x33LigShared4.212.890010
3x36LigShared8.253.780210
3x37Lignpy2_off3.2700010
4x61LigShared5.963.551210
4x65Lignpy2_off8.2200010
5x39LigShared3.610.251210
5x40LigShared4.625.270210
5x43Lignpy2_off3.6901010
5x44Lignpy2_off3.4101010
6x52Lignpy2_off11.0701010
6x55LigShared12.289.341210
7x34LigShared8.247.770210
7x38LigShared9.497.611210
1x392x60npy2_off3.7500221
1x397x38Shared8.717.620221
2x532x56Shared3.425.120021
2x563x28npy2_off3.4200212
2x563x32Shared9.169.160211
2x577x42Shared8.487.070222
2x63E1x50Shared8.689.651211
2x642x65npy2_off2.9500012
E1x50E1x52Shared10.4715.121212
3x25E1x50Shared5.225.221221
E1x50E2.Y189npy2_off3.8601212
3x25E2.Y189npy2_off4.0301222
3x25E2x50Shared7.287.281222
3x264x65Shared3.391.130021
3x283x29Shared3.533.530022
3x294x65Shared12.9711.530021
3x327x38npy2_off8.6501211
3x366x48Shared6.132.450212
3x374x53npy2_off4.3300012
3x374x56Shared3.991.330012
3x375x461Shared14.645.320012
4x605x39npy2_off15.300021
4x615x39Shared4.697.031211
4x65E2x50npy2_off4.1800012
4x65E2x52Shared5.825.820011
E2.E188E2x51Shared5.647.060211
E2.E188E2.K206Shared9.459.450212
E2.E193E2.I200npy2_off5.4700011
5x395x43npy2_off7.6301211
5x406x59Shared7.364.420211
5x445x47npy2_off3.5201012
5x446x52Shared6.431.291011
5x476x52Shared9.82.181021
6x486x52Shared10.583.171021
6x516x55npy2_off7.9900021
6x517x34Shared7.312.440021
6x526x55npy2_off6.1801011
6x546x58Shared11.82.626221
6x547x30Shared9.286.196221
6x547x34npy2_off7.506221
6x58E3.V297Shared3.213.210212
7x30E3.V297npy2_off6.3100212
7x267x30npy2_off3.4500021
7x277x30npy2_off5.8600021
7x327x35npy2_off4.4200021
7x387x42Shared13.1310.511212
E2.I194E2.I200npy2_off2.9400211
7x27E3.L298npy2_off2.7700021
E2.E211E2.K212npy2_off2.700012
7x267x29npy2_off2.600022
3x334x57npy2_off1.9500012
7x35Lignpy2_off1.8100010
2x563x31npy2_off1.8100212
E2.A202E2.I192npy2_off1.6200021
E2.E188E2.S190Shared1.444.310212
5x446x56npy2_off1.3801012
E1x49E2.I200npy2_off1.3700021
7x287x29Shared1.354.050212
2x63E2.A202Shared1.3341212
E2.E188Lignpy2_on_gp010.10210
E2.I192Lignpy2_on_gp06.050210
E2x51Lignpy2_on_gp04.290210
E2.E211Lignpy2_on_gp03.140010
E2.E193Lignpy2_on_gp06.750010
LigNT.L40npy2_on_gp09.561201
E2.I194Lignpy2_on_gp09.680210
7x28Lignpy2_on_gp03.710210
E3.L298Lignpy2_on_gp015.90210
E2.I200Lignpy2_on_gp02.940210
7x31Lignpy2_on_gp07.150010
7x30Lignpy2_on_gp012.260210
E2x52Lignpy2_on_gp012.790210
6x58Lignpy2_on_gp05.230210
6x59Lignpy2_on_gp05.960210
2x64Lignpy2_on_gp04.250010
2x56Lignpy2_on_gp02.680210
1x357x35npy2_on_gp05.90021
1x392x57npy2_on_gp03.520222
1x397x35npy2_on_gp04.990221
2x577x38npy2_on_gp02.570221
2x603x32npy2_on_gp04.250211
2x607x38npy2_on_gp010.950211
3x28E1x50npy2_on_gp06.130021
E1x50E2x50npy2_on_gp02.611212
3x254x65npy2_on_gp02.791221
3x283x32npy2_on_gp04.30021
E2.Y189E2x50npy2_on_gp04.031022
E2.I192E2.S190npy2_on_gp04.640212
E2.F198E2.I194npy2_on_gp06.280021
E2.F198E2.I200npy2_on_gp06.280021
E2.W207E2x52npy2_on_gp03.275221
5x39E2.W207npy2_on_gp01.931212
5x376x59npy2_on_gp02.890021
5x435x461npy2_on_gp04.51012
5x436x52npy2_on_gp02.791011
6x487x42npy2_on_gp02.331022
6x54E3.V297npy2_on_gp02.626222
6x557x34npy2_on_gp02.341211
7x30E3.L298npy2_on_gp04.690211
7x267x27npy2_on_gp02.710022
7x297x32npy2_on_gp06.630022
5x445x48npy2_on_gp01.491012
7x27E3.V297npy2_on_gp01.490022
E3.S295Lignpy2_on_gp01.390010
7x28NT.D42npy2_on_gp01.380212

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
Id Description
npy2_on_gp 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
npy2_off 7DDZ-Y2-JNJ-31020028
Network Difference
Value npy2_on_gp npy2_off
Imin 1.74 2.95
Number of Linked Nodes 855 270
Number of Specific Nodes 599 (70.06%) 14  (5.19%)
Number of Shared Nodes 256 (29.94%) 256  (94.81%)
Number of Links 1104 298
Number of Specific Links 947 (85.78%) 141  (47.32%)
Number of Shared Links 157 (14.22%) 157  (52.68%)
Number of Hubs 179 35
Number of Specific Hubs 162 (90.50%) 18  (51.43%)
Number of Shared Hubs 17 (9.50%) 17  (48.57%)
Average % Shared Neighbours (Jaccard) 12.06
Average % Shared Neighbours (Otsuka) 15.14
Average % Shared Neighbours (Overlap Coefficient) 18.10
Average % Shared Cliques (k3-6) 50.43
Graphlets Similarity 0.637835
Paths Difference
Value npy2_on_gp npy2_off
Number Of Nodes in MetaPath 59 102
Specific Nodes in MetaPath 49 (83.05%) 92  (90.20%)
Shared Nodes in MetaPath 256 (29.94%) 256  (29.94%)
Number Of Links MetaPath 60 107
Specific Links in MetaPath 57 (95.00%) 104  (97.20%)
Shared Links in MetaPath 157 (14.22%) 157  (14.22%)
Number of Shortest Paths 2109303 55205
Length Of Smallest Path 3 3
Average Path Length 29.3396 12.7589
Length of Longest Path 51 27
Minimum Path Strength 1.225 1.32
Average Path Strength 4.31291 6.1897
Maximum Path Strength 17.355 19.365
Minimum Path Correlation 0.7 0.7
Average Path Correlation 0.986216 0.92526
Maximum Path Correlation 1 0.99
Minimum % Of Corr. Nodes 2.38095 4.16667
Average % Of Corr. Nodes 38.6141 51.1476
Maximum % Of Corr. Nodes 100 100
Minimum Path Hubs % 0 0
Average Path Hubs % 56.5631 38.5273
Maximum Path Hubs % 100 100

Details about the values in these tables can be found in the corresponding documentation page .

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download npy2_off_on_gp.zip<



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