psnGPCR

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Orange: nodes, hubs and links specific of nts1_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of nts1_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	nts1_off Int. Strength	nts1_on Int. Strength	nts1_off Hub1?	nts1_on Hub1?	nts1_off Hub2?	nts1_on Hub2?	ConSurf1	ConSurf2
1	1x35	2x65	nts1_off	4.61	0	No	No	No	No	5	5
2	1x39	2x60	nts1_off	5.625	0	Yes	No	Yes	Yes	7	7
3	1x39	2x61	nts1_off	5.275	0	Yes	No	No	No	7	6
4	1x39	2x65	nts1_off	4.23	0	Yes	No	No	No	7	5
5	1x39	7x42	nts1_off	5.96	0	Yes	No	Yes	No	7	7
6	1x50	2x51	nts1_off	3.435	0	No	No	Yes	No	9	8
7	1x53	1x57	nts1_off	2.95	0	No	No	No	No	9	7
8	1x60	2x40	nts1_off	11.75	0	No	No	No	No	5	8
9	2x33	2x36	nts1_off	3.2	0	Yes	No	Yes	No	4	7
10	2x33	6x29	nts1_off	3.03	0	Yes	No	No	No	4	6
11	2x33	6x32	nts1_off	2.92	0	Yes	No	Yes	No	4	8
12	2x34	2x38	nts1_off	5.93	0	No	No	Yes	Yes	5	6
13	2x34	4x39	nts1_off	4.615	0	No	No	No	No	5	4
14	2x35	2x38	nts1_off	6.68	0	No	No	Yes	Yes	8	6
15	2x35	6x29	nts1_off	3.94	0	No	No	No	No	8	6
16	2x35	6x30	nts1_off	3.46	0	No	No	No	No	8	8
17	2x36	6x32	nts1_off	12.27	0	Yes	No	Yes	No	7	8
18	2x42	3x46	nts1_off	11.72	0	Yes	Yes	No	No	8	9
19	2x42	4x42	nts1_off	4.995	0	Yes	Yes	No	No	8	7
20	2x43	6x36	nts1_off	4.47	0	No	No	No	No	8	8
21	2x43	7x53	nts1_off	8.795	0	No	No	Yes	Yes	8	9
22	2x46	3x39	nts1_off	3.685	0	No	No	Yes	No	9	9
23	2x49	4x50	nts1_off	4.94	0	No	No	Yes	Yes	8	9
24	2x50	7x46	nts1_off	5.26	0	No	Yes	No	No	9	9
25	2x52	3x35	nts1_off	3.965	0	No	No	No	No	6	7
26	2x53	3x32	nts1_off	3.135	0	No	No	Yes	No	7	7
27	2x53	7x41	nts1_off	3.28	0	No	No	Yes	No	7	7
28	2x55	2x551	nts1_off	3.045	0	No	No	No	No	5	5
29	2x61	2x66	nts1_off	17.655	0	No	No	No	Yes	6	7
30	2x62	E1x52	nts1_off	4.64	0	Yes	No	Yes	Yes	4	7
31	2x64	2x65	nts1_off	5.025	0	Yes	Yes	No	No	6	5
32	2x64	7x38	nts1_off	3.625	0	Yes	Yes	Yes	Yes	6	6
33	2x67	E1	nts1_off	7.805	0	No	No	No	No	5	5
34	E1x50	E2	nts1_off	4.555	0	Yes	Yes	Yes	Yes	9	4
35	3x25	E2	nts1_off	3.545	0	No	No	Yes	Yes	9	4
36	3x28	3x32	nts1_off	10.29	0	Yes	Yes	Yes	No	6	7
37	3x29	4x61	nts1_off	2.995	0	Yes	No	No	No	5	6
38	3x29	Lig	nts1_off	6.04	0	Yes	No	Yes	Yes	5	0
39	3x32	7x41	nts1_off	13.185	0	Yes	No	Yes	No	7	7
40	3x32	7x42	nts1_off	6.685	0	Yes	No	Yes	No	7	7
41	3x33	3x37	nts1_off	7.35	0	Yes	No	Yes	No	6	6
42	3x33	4x57	nts1_off	3.825	0	Yes	No	No	No	6	7
43	3x36	5x461	nts1_off	3.2	0	No	No	Yes	No	7	6
44	3x37	5x461	nts1_off	6.995	0	Yes	No	Yes	No	6	6
45	3x39	6x44	nts1_off	5.185	0	Yes	No	Yes	No	9	9
46	3x41	4x49	nts1_off	4.995	0	No	No	No	No	7	8
47	3x45	4x49	nts1_off	3.87	0	No	No	No	No	7	8
48	3x46	6x37	nts1_off	4.155	0	No	No	Yes	No	9	8
49	3x47	5x54	nts1_off	3.42	0	No	No	No	No	9	8
50	3x47	6x37	nts1_off	3.75	0	No	No	Yes	No	9	8
51	3x49	I2x57	nts1_off	10.83	0	Yes	No	No	No	9	6
52	3x49	4x42	nts1_off	12.7	0	Yes	No	No	No	9	7
53	3x50	6x33	nts1_off	3.42	0	No	No	No	No	9	8
54	3x50	6x34	nts1_off	2.98	0	No	No	No	Yes	9	7
55	3x50	6x37	nts1_off	3.46	0	No	No	Yes	No	9	8
56	3x54	5x65	nts1_off	6.425	0	Yes	No	No	No	8	8
57	3x54	5x68	nts1_off	5.105	0	Yes	No	No	No	8	6
58	3x54	6x30	nts1_off	4.28	0	Yes	No	No	No	8	8
59	3x55	3x56	nts1_off	4.42	0	No	No	No	No	7	6
60	I2x50	I2x51	nts1_off	3.61	0	No	No	No	No	9	6
61	I2x52	I2x56	nts1_off	5.64	0	No	No	No	No	5	5
62	6x26	I2x54	nts1_off	5.57	0	Yes	No	No	No	5	4
63	I2x55	I2x56	nts1_off	5.16	0	No	No	No	No	4	5
64	4x61	4x64	nts1_off	4.52	0	No	No	No	Yes	6	4
65	E2x52	Lig	nts1_off	3.15	0	Yes	Yes	Yes	Yes	5	0
66	5x33	5x37	nts1_off	5.82	0	No	No	No	No	1	4
67	5x36	6x58	nts1_off	9.745	0	No	No	No	No	5	3
68	5x36	Lig	nts1_off	3.56	0	No	No	Yes	Yes	5	0
69	5x37	6x59	nts1_off	4.58	0	No	No	No	No	4	4
70	5x40	6x55	nts1_off	5.01	0	No	No	Yes	Yes	5	6
71	5x40	6x58	nts1_off	7.535	0	No	No	No	No	5	3
72	5x41	6x59	nts1_off	6.445	0	No	No	No	No	6	4
73	5x43	5x461	nts1_off	6.705	0	Yes	No	Yes	No	5	6
74	5x44	6x55	nts1_off	3.88	0	No	No	Yes	Yes	5	6
75	5x45	5x49	nts1_off	3.215	0	No	No	No	No	4	5
76	5x47	6x48	nts1_off	3.505	0	Yes	No	Yes	Yes	8	8
77	5x53	5x57	nts1_off	2.98	0	No	No	No	No	5	7
78	5x58	6x38	nts1_off	11.45	0	No	No	No	No	9	5
79	5x63	5x66	nts1_off	3.235	0	No	No	No	No	5	5
80	5x65	5x69	nts1_off	2.98	0	No	No	No	No	8	5
81	6x26	6x30	nts1_off	8.505	0	Yes	No	No	No	5	8
82	6x28	6x31	nts1_off	3.505	0	No	No	No	No	5	6
83	6x28	6x32	nts1_off	3.505	0	No	No	Yes	No	5	8
84	6x31	6x35	nts1_off	3.035	0	No	No	No	No	6	7
85	6x37	6x41	nts1_off	2.98	0	Yes	No	No	No	8	8
86	6x47	6x48	nts1_off	3.92	0	No	No	Yes	Yes	8	8
87	6x48	6x51	nts1_off	5.305	0	Yes	Yes	Yes	Yes	8	5
88	6x49	6x50	nts1_off	4.105	0	No	No	No	No	6	9
89	6x51	7x41	nts1_off	6.535	0	Yes	Yes	Yes	No	5	7
90	6x53	7x33	nts1_off	4.585	0	No	No	No	No	5	5
91	6x54	7x38	nts1_off	9.04	0	Yes	Yes	Yes	Yes	5	6
92	6x56	6x60	nts1_off	5.275	0	No	No	No	No	5	5
93	6x57	7x33	nts1_off	4.975	0	No	No	No	No	5	5
94	6x57	Lig	nts1_off	10.43	0	No	No	Yes	Yes	5	0
95	6x61	7x30	nts1_off	3.025	0	No	No	Yes	Yes	3	4
96	6x61	Lig	nts1_off	5.085	0	No	No	Yes	Yes	3	0
97	7x29	7x30	nts1_off	4.125	0	No	No	Yes	Yes	4	4
98	7x31	7x35	nts1_off	7.88	0	No	No	No	No	4	4
99	7x32	7x36	nts1_off	13.48	0	No	No	No	No	1	5
100	7x45	7x49	nts1_off	2.98	0	Yes	No	Yes	No	9	9
101	7x48	7x52	nts1_off	6.425	0	No	No	No	No	6	8
102	7x53	7x54	nts1_off	8.725	0	Yes	Yes	No	No	9	7
103	1x31	NT	nts1_off	5.155	0	No	No	No	Yes	2	0
104	2x36	6x29	nts1_off	3.03	0	Yes	No	No	No	7	6
105	2x50	6x44	nts1_off	2.985	0	No	Yes	Yes	No	9	9
106	I2x51	I2x52	nts1_off	4.345	0	No	No	No	No	6	5
107	5x64	5x67	nts1_off	3.925	0	No	No	No	No	5	5
108	6x27	6x31	nts1_off	3.27	0	No	No	No	No	3	6
109	6x32	6x35	nts1_off	4.25	0	Yes	No	No	No	8	7
110	6x40	7x49	nts1_off	5.175	0	No	No	Yes	No	8	9
111	6x44	7x45	nts1_off	4.625	0	Yes	No	Yes	No	9	9
112	6x44	7x49	nts1_off	5.435	0	Yes	No	Yes	No	9	9
113	7x26	7x30	nts1_off	5.86	0	No	No	Yes	Yes	0	4
114	6x26	I2x50	nts1_off	2.88	0	Yes	No	No	No	5	9
115	4x59	4x62	nts1_off	2.855	0	Yes	No	No	No	4	5
116	3x53	6x26	nts1_off	2.77	0	No	No	Yes	No	8	5
117	1x54	2x51	nts1_off	2.765	0	No	No	Yes	No	7	8
118	2x56	3x32	nts1_off	2.765	0	No	No	Yes	No	6	7
119	1x48	1x49	nts1_off	2.76	0	No	No	No	No	4	8
120	2x33	6x25	nts1_off	2.465	0	Yes	No	No	No	4	3
121	6x43	7x49	nts1_off	2.345	0	No	No	Yes	No	5	9
122	5x34	E2	nts1_off	2.315	0	No	No	Yes	Yes	3	4
123	1x30	NT	nts1_off	2.3	0	No	No	No	Yes	3	0
124	4x40	4x44	nts1_off	2.295	0	No	No	No	No	4	3
125	2x39	2x43	nts1_off	2.235	0	No	No	No	No	8	8
126	2x39	3x46	nts1_off	2.235	0	No	No	No	No	8	9
127	3x48	3x52	nts1_off	2.235	0	No	No	No	No	6	4
128	7x48	7x49	nts1_off	2.125	0	No	No	Yes	No	6	9
129	3x52	I2x57	nts1_off	2.12	0	No	No	No	No	4	6
130	5x42	5x46	nts1_off	2.12	0	No	No	No	No	4	4
131	3x21	E1x50	nts1_off	2.11	0	No	No	Yes	Yes	8	9
132	1x49	7x50	nts1_off	2.03	0	No	No	No	No	8	9
133	6x24	6x25	nts1_off	2.03	0	No	No	No	No	3	3
134	3x43	6x44	nts1_off	1.965	0	No	No	Yes	No	8	9
135	2x44	2x47	nts1_off	1.95	0	No	No	No	No	5	9
136	6x38	6x42	nts1_off	1.88	0	No	No	No	No	5	5
137	3x26	3x27	nts1_off	1.74	0	No	No	No	No	7	4
138	1x46	2x54	nts1_off	1.71	0	No	No	No	No	8	6
139	1x51	1x54	nts1_off	1.71	0	No	No	No	No	4	7
140	7x31	Lig	nts1_off	1.665	0	No	No	Yes	Yes	4	0
141	1x52	1x56	nts1_off	1.59	0	No	No	No	No	6	7
142	1x45	7x51	nts1_off	1.54	0	No	No	No	No	5	7
143	5x56	5x60	nts1_off	1.54	0	No	No	No	No	4	5
144	7x24	7x28	nts1_off	1.445	0	No	No	No	No	0	3
145	1x34	1x38	nts1_off	1.425	0	No	No	No	No	5	4
146	7x36	7x40	nts1_off	1.385	0	No	No	No	No	5	7
147	4x59	4x63	nts1_off	1.26	0	Yes	No	No	No	4	4
148	3x23	3x24	nts1_off	0.975	0	No	No	No	No	1	4
149	3x53	I2x53	nts1_off	0.895	0	No	No	No	No	8	6
150	1x29	1x33	nts1_off	0.77	0	No	No	No	No	3	5
151	1x31	1x32	nts1_off	0.765	0	No	No	No	No	2	5
152	1x31	7x35	nts1_off	0.765	0	No	No	No	No	2	4
153	4x40	4x43	nts1_off	0.765	0	No	No	No	No	4	4
154	4x55	4x59	nts1_off	0.715	0	No	No	Yes	No	4	4
155	3x30	4x54	nts1_off	0.695	0	No	Yes	No	No	5	2
156	1x58	1x59	nts1_off	0.69	0	No	No	No	No	2	6
157	2x62	E1x51	nts1_off	0.665	0	Yes	No	No	No	4	4
158	6x39	7x53	nts1_off	0.665	0	No	No	Yes	Yes	6	9
159	1x56	1x59	nts1_off	0.645	0	No	No	No	No	7	6
160	7x28	7x31	nts1_off	0.63	0	No	No	No	No	3	4
161	1x35	1x39	Shared	3.79	8.83	No	No	Yes	No	5	7
162	1x36	2x66	Shared	12.13	7.28	No	No	No	Yes	6	7
163	1x39	2x57	Shared	4.69	3.59	Yes	No	Yes	Yes	7	7
164	1x39	7x39	Shared	4	4	Yes	No	No	No	7	5
165	1x42	7x43	Shared	4.47	2.98	No	No	No	No	7	6
166	1x42	7x47	Shared	3.15	7.37	No	No	No	No	7	6
167	1x43	1x47	Shared	7.78	5.19	No	Yes	No	No	6	6
168	1x43	2x57	Shared	3.045	6.22	No	Yes	Yes	Yes	6	7
169	1x47	2x51	Shared	3.685	2.95	No	No	Yes	No	6	8
170	1x47	2x55	Shared	4.425	2.95	No	No	No	No	6	5
171	1x50	2x50	Shared	10.095	4.04	No	No	No	Yes	9	9
172	1x50	7x50	Shared	12.215	6.52	No	No	No	No	9	9
173	1x53	2x47	Shared	3.36	3.36	No	No	No	No	9	9
174	1x54	2x47	Shared	3.15	3.15	No	No	No	No	7	9
175	1x57	2x40	Shared	4.75	5.14	No	No	No	No	7	8
176	2x36	I1	Shared	5.78	5.32	Yes	No	No	Yes	7	5
177	2x37	I1	Shared	4.075	9.04	No	No	No	Yes	7	5
178	2x37	4x39	Shared	6.585	9.22	No	No	No	No	7	4
179	2x38	3x49	Shared	6.975	4.23	Yes	Yes	Yes	No	6	9
180	2x38	I2x57	Shared	6.825	1.51	Yes	Yes	No	No	6	6
181	2x38	4x42	Shared	11.645	10.99	Yes	Yes	No	No	6	7
182	2x41	4x39	Shared	8.745	9.26	No	No	No	No	4	4
183	2x42	3x45	Shared	7.63	5.58	Yes	Yes	No	No	8	7
184	2x42	3x49	Shared	12.91	8.62	Yes	Yes	Yes	No	8	9
185	2x42	4x46	Shared	6.045	5.3	Yes	Yes	No	No	8	7
186	2x45	3x42	Shared	8.94	8.94	No	No	No	Yes	9	8
187	2x45	4x46	Shared	3.1	4.64	No	No	No	No	9	7
188	2x45	4x50	Shared	6.18	6.18	No	No	Yes	Yes	9	9
189	2x46	3x42	Shared	7.555	5.49	No	No	No	Yes	9	8
190	2x48	4x50	Shared	9.11	3.42	No	No	Yes	Yes	6	9
191	2x49	3x39	Shared	4	4.8	No	No	Yes	No	8	9
192	2x51	2x55	Shared	4.845	6.92	Yes	No	No	No	8	5
193	2x53	3x35	Shared	6.55	3.38	No	No	No	No	7	7
194	2x551	3x31	Shared	7.92	6.92	No	No	No	No	5	5
195	2x57	2x58	Shared	5.75	3.35	Yes	Yes	No	No	7	9
196	2x57	7x42	Shared	10.55	7.18	Yes	Yes	Yes	No	7	7
197	2x59	E1x52	Shared	9.835	3.93	No	No	Yes	Yes	5	7
198	2x59	3x28	Shared	9.465	11.36	No	No	Yes	Yes	5	6
199	2x60	2x64	Shared	5.335	4.66	Yes	Yes	Yes	Yes	7	6
200	2x60	3x28	Shared	6.845	4.49	Yes	Yes	Yes	Yes	7	6
201	2x60	3x32	Shared	3.505	9.3	Yes	Yes	Yes	No	7	7
202	2x60	7x38	Shared	8.625	9.2	Yes	Yes	Yes	Yes	7	6
203	2x60	7x42	Shared	13.6	11.22	Yes	Yes	Yes	No	7	7
204	2x62	2x63	Shared	8.14	5.81	Yes	No	No	No	4	5
205	2x62	2x67	Shared	12.62	8.83	Yes	No	No	No	4	5
206	2x63	E1x50	Shared	11.865	9.04	No	No	Yes	Yes	5	9
207	2x63	E1x52	Shared	8.46	4.83	No	No	Yes	Yes	5	7
208	2x64	7x34	Shared	8.25	12.38	Yes	Yes	Yes	Yes	6	4
209	E1x50	E1x52	Shared	11.525	10.02	Yes	Yes	Yes	Yes	9	7
210	3x25	E1x50	Shared	4.57	9.14	No	No	Yes	Yes	9	9
211	E1x50	E2x50	Shared	13.06	19.59	Yes	Yes	No	No	9	9
212	3x22	3x26	Shared	10.37	14.29	No	No	No	No	3	7
213	3x22	E2	Shared	8.785	8.55	No	No	Yes	Yes	3	4
214	3x25	E2x50	Shared	7.28	7.28	No	No	No	No	9	9
215	3x28	3x29	Shared	13.405	5.96	Yes	Yes	Yes	No	6	5
216	3x29	4x65	Shared	12.575	10.78	Yes	No	No	Yes	5	5
217	3x30	4x57	Shared	4.16	4.16	No	Yes	No	No	5	7
218	3x30	4x62	Shared	10.96	10.96	No	Yes	No	No	5	5
219	3x32	6x51	Shared	7.715	9.26	Yes	No	Yes	Yes	7	5
220	3x32	7x38	Shared	3.015	3.62	Yes	No	Yes	Yes	7	6
221	3x33	4x61	Shared	8.2	9.7	Yes	No	No	No	6	6
222	3x33	5x43	Shared	15.275	4.04	Yes	No	Yes	No	6	5
223	3x36	6x48	Shared	4.245	3.64	No	No	Yes	Yes	7	8
224	3x37	4x56	Shared	15.235	14.07	Yes	No	No	No	6	5
225	3x37	5x43	Shared	6.98	9.3	Yes	No	Yes	No	6	5
226	3x37	5x46	Shared	5.985	4.79	Yes	No	No	No	6	4
227	3x38	4x50	Shared	7.78	7.78	No	No	Yes	Yes	7	9
228	3x38	4x53	Shared	3.42	3.42	No	No	No	No	7	8
229	3x39	6x48	Shared	3.635	4.85	Yes	No	Yes	Yes	9	8
230	3x40	5x50	Shared	3.74	3.74	No	No	No	Yes	7	9
231	3x42	4x49	Shared	7.08	4.25	No	Yes	No	No	8	8
232	3x45	4x45	Shared	3.3	5.28	No	No	No	No	7	5
233	3x47	5x57	Shared	5.255	6.01	No	No	No	No	9	7
234	3x51	3x55	Shared	9.41	6.72	Yes	Yes	No	No	8	7
235	3x51	3x56	Shared	4.355	6.53	Yes	Yes	No	No	8	6
236	3x51	5x57	Shared	11.72	10.55	Yes	Yes	No	No	8	7
237	3x51	5x60	Shared	3.79	3.63	Yes	Yes	No	No	8	5
238	4x38	4x40	Shared	3.26	1.63	No	No	No	No	7	4
239	4x38	4x41	Shared	5.93	9.22	No	No	No	No	7	6
240	4x59	4x60	Shared	3.39	3.53	Yes	No	No	No	4	8
241	4x64	5x39	Shared	3.175	1.59	No	Yes	No	No	4	7
242	4x65	E2x52	Shared	5.87	10.06	No	Yes	Yes	Yes	5	5
243	4x65	Lig	Shared	5.005	4.24	No	Yes	Yes	Yes	5	0
244	E2	E2	Shared	22.57	69.07	Yes	Yes	Yes	Yes	4	4
245	E2	E2x51	Shared	13.18	19.21	Yes	Yes	No	No	4	3
246	E2x51	E2x52	Shared	5.25	5.25	No	No	Yes	Yes	3	5
247	5x36	E2x52	Shared	3.28	5.3	No	No	Yes	Yes	5	5
248	5x35	E2	Shared	8.165	3.04	No	No	Yes	Yes	4	4
249	5x40	Lig	Shared	4.145	5.71	No	No	Yes	Yes	5	0
250	5x41	6x60	Shared	9.58	1.13	No	No	No	No	6	5
251	5x43	6x55	Shared	5.425	14.46	Yes	No	Yes	Yes	5	6
252	5x44	6x52	Shared	11.635	12.32	No	No	Yes	Yes	5	7
253	5x44	6x56	Shared	5.16	7.37	No	No	No	No	5	5
254	5x461	6x52	Shared	3.485	6.97	Yes	No	Yes	Yes	6	7
255	5x47	5x51	Shared	3.73	7.46	Yes	No	No	No	8	7
256	5x47	6x49	Shared	5.48	7.31	Yes	No	No	No	8	6
257	5x47	6x52	Shared	20.93	4.53	Yes	No	Yes	Yes	8	7
258	5x49	5x53	Shared	3.935	3.93	No	No	No	No	5	5
259	5x51	6x45	Shared	3.04	3.04	No	No	No	No	7	6
260	5x52	5x56	Shared	4.28	1.6	No	No	No	No	3	4
261	5x58	6x37	Shared	10.985	9.61	No	No	Yes	No	9	8
262	5x64	5x68	Shared	4.34	4.32	No	No	No	No	5	6
263	6x44	6x48	Shared	9.02	7.02	Yes	No	Yes	Yes	9	8
264	6x47	7x45	Shared	6.025	3.44	No	No	Yes	No	8	9
265	6x48	7x41	Shared	15.035	12.03	Yes	Yes	Yes	No	8	7
266	6x49	6x53	Shared	2.98	2.98	No	No	No	No	6	5
267	6x50	7x40	Shared	4.105	4.93	No	No	No	No	9	7
268	6x51	6x52	Shared	9.255	6.53	Yes	Yes	Yes	Yes	5	7
269	6x51	6x54	Shared	7.715	8.23	Yes	Yes	Yes	Yes	5	5
270	6x51	6x55	Shared	10.805	8.23	Yes	Yes	Yes	Yes	5	6
271	6x54	7x34	Shared	15.95	11.32	Yes	Yes	Yes	Yes	5	4
272	6x54	7x37	Shared	9.225	7.76	Yes	Yes	No	Yes	5	5
273	6x54	Lig	Shared	10.645	4.86	Yes	Yes	Yes	Yes	5	0
274	6x55	Lig	Shared	6.3	8.5	Yes	Yes	Yes	Yes	6	0
275	6x58	Lig	Shared	20.055	17.32	No	No	Yes	Yes	3	0
276	6x59	6x60	Shared	12.62	5.38	No	No	No	No	4	5
277	7x30	Lig	Shared	14.32	10.91	Yes	Yes	Yes	Yes	4	0
278	7x34	Lig	Shared	17.775	6.04	Yes	Yes	Yes	Yes	4	0
279	7x43	7x48	Shared	3.07	1.54	No	No	No	No	6	6
280	3x26	E2	Shared	3.34	6	No	No	Yes	Yes	7	4
281	5x45	5x48	Shared	4.87	8.79	No	No	No	No	4	5
282	6x48	7x45	Shared	3.09	8.65	Yes	Yes	Yes	No	8	9
283	E3	E3	Shared	7.66	5.72	Yes	Yes	Yes	Yes	3	3
284	7x26	E3	Shared	5.125	3.42	No	No	Yes	Yes	0	3
285	7x30	E3	Shared	4.34	4.82	Yes	Yes	Yes	Yes	4	3
286	7x34	7x38	Shared	4.65	10.47	Yes	Yes	Yes	Yes	4	6
287	7x41	7x42	Shared	4.125	5.16	Yes	No	Yes	No	7	7
288	7x49	7x53	Shared	2.905	6.98	Yes	No	Yes	Yes	9	9
289	5x49	5x50	Shared	2.885	4.33	No	No	No	Yes	5	9
290	1x38	1x42	Shared	2.85	2.98	No	No	No	No	4	7
291	7x27	Lig	Shared	2.755	29.24	No	No	Yes	Yes	3	0
292	5x66	5x70	Shared	2.74	3.88	No	No	No	No	5	4
293	3x54	5x61	Shared	2.435	4.42	Yes	No	No	No	8	8
294	1x29	1x30	Shared	2.42	3.63	No	No	No	No	3	3
295	1x36	1x40	Shared	2.21	1.47	No	No	No	No	6	3
296	1x46	7x47	Shared	1.95	3.64	No	No	No	No	8	6
297	3x34	4x57	Shared	1.79	1.79	No	No	No	No	5	7
298	3x44	5x50	Shared	1.77	1.87	No	No	No	Yes	7	9
299	5x62	6x34	Shared	1.7	1.7	No	No	No	Yes	6	7
300	5x55	6x41	Shared	1.62	1.62	No	No	No	No	5	8
301	1x44	1x45	Shared	1.6	1.6	No	No	No	No	5	5
302	1x48	1x52	Shared	1.6	1.6	No	No	No	No	4	6
303	6x42	6x46	Shared	1.54	1.54	No	No	No	No	5	5
304	3x24	E1x52	Shared	1.51	1.51	No	No	Yes	Yes	4	7
305	5x38	5x42	Shared	1.49	1.6	No	No	No	No	4	4
306	7x23	7x26	Shared	1.475	8.84	No	No	No	No	0	0
307	1x43	1x44	Shared	1.31	1.31	No	Yes	No	No	6	5
308	1x55	1x59	Shared	1.07	13.9	No	No	No	No	3	6
309	7x23	7x25	Shared	0.84	2.59	No	No	No	No	0	0
310	5x63	5x67	Shared	0.655	1.48	No	No	No	No	5	5
311	NT	NT	nts1_on	0	10.19	No	Yes	No	Yes	0	0
312	E2	NT	nts1_on	0	23.32	Yes	Yes	No	Yes	4	0
313	E1	NT	nts1_on	0	42.56	No	No	No	Yes	5	0
314	Lig	NT	nts1_on	0	5.86	Yes	Yes	No	Yes	0	0
315	7x27	NT	nts1_on	0	5.05	No	No	No	Yes	3	0
316	7x31	NT	nts1_on	0	16.61	No	No	No	Yes	4	0
317	7x28	NT	nts1_on	0	8.08	No	No	No	Yes	3	0
318	1x32	NT	nts1_on	0	7.51	No	No	No	Yes	5	0
319	7x32	NT	nts1_on	0	4.99	No	No	No	Yes	1	0
320	1x28	1x31	nts1_on	0	5.89	No	No	No	No	0	2
321	1x28	7x32	nts1_on	0	10.34	No	No	No	No	0	1
322	1x32	2x66	nts1_on	0	12.76	No	No	No	Yes	5	7
323	1x35	7x35	nts1_on	0	10.65	No	No	No	No	5	4
324	1x43	2x54	nts1_on	0	4.87	No	Yes	No	No	6	6
325	1x52	8x54	nts1_on	0	6.55	No	No	No	No	6	0
326	1x53	7x54	nts1_on	0	8.77	No	No	No	No	9	7
327	1x53	8x50	nts1_on	0	5.19	No	No	No	Yes	9	0
328	1x56	8x50	nts1_on	0	7.78	No	No	No	Yes	7	0
329	1x60	I1	nts1_on	0	6	No	No	No	Yes	5	5
330	I1	I1	nts1_on	0	12.69	No	Yes	No	Yes	5	5
331	2x40	I1	nts1_on	0	15.43	No	No	No	Yes	8	5
332	4x39	I1	nts1_on	0	11.68	No	No	No	Yes	4	5
333	2x34	2x36	nts1_on	0	8.66	No	No	Yes	No	5	7
334	2x35	I2x54	nts1_on	0	5.64	No	No	No	No	8	4
335	2x35	I2x57	nts1_on	0	5.65	No	No	No	No	8	6
336	2x36	2x40	nts1_on	0	7.42	Yes	No	No	No	7	8
337	2x37	2x41	nts1_on	0	5.09	No	No	No	No	7	4
338	2x41	4x43	nts1_on	0	7.17	No	No	No	No	4	4
339	2x42	4x45	nts1_on	0	4.53	Yes	Yes	No	No	8	5
340	2x43	3x46	nts1_on	0	4.15	No	No	No	No	8	9
341	2x43	7x54	nts1_on	0	5.49	No	No	No	No	8	7
342	2x46	2x50	nts1_on	0	5.43	No	No	No	Yes	9	9
343	2x46	7x53	nts1_on	0	7.03	No	No	Yes	Yes	9	9
344	2x49	3x42	nts1_on	0	4.47	No	No	No	Yes	8	8
345	2x50	3x39	nts1_on	0	7.23	No	Yes	Yes	No	9	9
346	2x50	7x49	nts1_on	0	9.42	No	Yes	Yes	No	9	9
347	2x53	7x46	nts1_on	0	6.4	No	No	No	No	7	9
348	2x56	3x28	nts1_on	0	4	No	No	Yes	Yes	6	6
349	2x57	2x61	nts1_on	0	5.65	Yes	Yes	No	No	7	6
350	2x60	7x34	nts1_on	0	5.61	Yes	Yes	Yes	Yes	7	4
351	2x64	E1x50	nts1_on	0	4.01	Yes	Yes	Yes	Yes	6	9
352	2x64	3x28	nts1_on	0	4.13	Yes	Yes	Yes	Yes	6	6
353	2x64	3x29	nts1_on	0	5.16	Yes	Yes	Yes	No	6	5
354	2x64	Lig	nts1_on	0	10.05	Yes	Yes	Yes	Yes	6	0
355	E1	Lig	nts1_on	0	6.78	No	No	Yes	Yes	5	0
356	E1x49	E2	nts1_on	0	6.09	No	No	Yes	Yes	0	4
357	E1x51	E1x52	nts1_on	0	4.16	No	No	Yes	Yes	4	7
358	3x21	E2	nts1_on	0	4.91	No	No	Yes	Yes	8	4
359	3x36	7x41	nts1_on	0	7.78	No	No	Yes	No	7	7
360	3x41	4x53	nts1_on	0	4.5	No	No	No	No	7	8
361	3x42	4x50	nts1_on	0	4.52	No	Yes	Yes	Yes	8	9
362	3x43	7x53	nts1_on	0	5.05	No	No	Yes	Yes	8	9
363	3x46	3x50	nts1_on	0	3.64	No	No	No	No	9	9
364	3x46	7x53	nts1_on	0	4.69	No	No	Yes	Yes	9	9
365	3x47	5x58	nts1_on	0	5.96	No	No	No	No	9	9
366	3x50	7x53	nts1_on	0	5.14	No	No	Yes	Yes	9	9
367	3x51	5x61	nts1_on	0	3.63	Yes	Yes	No	No	8	8
368	4x63	4x64	nts1_on	0	3.89	No	No	No	Yes	4	4
369	4x64	4x65	nts1_on	0	7.53	No	Yes	No	Yes	4	5
370	4x64	E2	nts1_on	0	6.08	No	Yes	Yes	Yes	4	4
371	E2	Lig	nts1_on	0	16.17	Yes	Yes	Yes	Yes	4	0
372	6x58	E2x52	nts1_on	0	5.78	No	No	Yes	Yes	3	5
373	5x37	6x60	nts1_on	0	4.78	No	No	No	No	4	5
374	5x40	6x59	nts1_on	0	8.18	No	No	No	No	5	4
375	5x45	5x46	nts1_on	0	6.22	No	No	No	No	4	4
376	5x50	6x44	nts1_on	0	5.78	No	Yes	Yes	No	9	9
377	5x51	6x44	nts1_on	0	4.98	No	No	Yes	No	7	9
378	5x54	6x41	nts1_on	0	4.61	No	No	No	No	8	8
379	5x58	6x41	nts1_on	0	4.43	No	No	No	No	9	8
380	5x61	6x37	nts1_on	0	4.28	No	No	Yes	No	8	8
381	5x65	6x34	nts1_on	0	4.47	No	No	No	Yes	8	7
382	5x69	6x31	nts1_on	0	3.92	No	No	No	No	5	6
383	6x32	7x56	nts1_on	0	4.15	Yes	No	No	No	8	0
384	6x40	7x53	nts1_on	0	7.57	No	No	Yes	Yes	8	9
385	6x51	7x38	nts1_on	0	5.81	Yes	Yes	Yes	Yes	5	6
386	6x54	6x55	nts1_on	0	7.46	Yes	Yes	Yes	Yes	5	6
387	6x54	7x30	nts1_on	0	11.32	Yes	Yes	Yes	Yes	5	4
388	6x54	7x33	nts1_on	0	4.28	Yes	Yes	No	No	5	5
389	6x58	7x30	nts1_on	0	6.19	No	No	Yes	Yes	3	4
390	6x61	E3	nts1_on	0	17.23	No	No	Yes	Yes	3	3
391	E3	Lig	nts1_on	0	20.47	Yes	Yes	Yes	Yes	3	0
392	7x27	7x31	nts1_on	0	18.51	No	No	No	No	3	4
393	7x33	7x37	nts1_on	0	7.78	No	No	No	Yes	5	5
394	7x37	7x38	nts1_on	0	4.39	No	Yes	Yes	Yes	5	6
395	7x54	8x50	nts1_on	0	13.29	No	No	No	Yes	7	0
396	7x55	8x54	nts1_on	0	7.31	No	No	No	No	5	0
397	8x48	8x51	nts1_on	0	5.53	No	No	No	No	0	0
398	8x50	8x54	nts1_on	0	8.57	No	Yes	No	No	0	0
399	Lig	Lig	nts1_on	0	8.19	Yes	Yes	Yes	Yes	0	0
400	2x65	2x66	nts1_on	0	3.52	No	No	No	Yes	5	7
401	6x50	7x37	nts1_on	0	3.5	No	No	No	Yes	9	5
402	7x23	7x24	nts1_on	0	3.5	No	No	No	No	0	0
403	6x47	7x43	nts1_on	0	3.42	No	No	No	No	8	6
404	7x45	7x46	nts1_on	0	3.26	Yes	No	No	No	9	9
405	3x55	5x64	nts1_on	0	3.23	No	No	No	No	7	5
406	5x55	5x56	nts1_on	0	3.23	No	No	No	No	5	4
407	2x38	2x39	nts1_on	0	3.17	Yes	Yes	No	No	6	8
408	5x66	6x34	nts1_on	0	3.17	No	No	No	Yes	5	7
409	3x43	5x54	nts1_on	0	3.07	No	No	No	No	8	8
410	1x56	8x53	nts1_on	0	3.04	No	No	No	No	7	0
411	3x48	5x57	nts1_on	0	2.98	No	No	No	No	6	7
412	5x69	6x30	nts1_on	0	2.98	No	No	No	No	5	8
413	1x51	2x51	nts1_on	0	2.95	No	No	Yes	No	4	8
414	1x29	1x32	nts1_on	0	2.91	No	No	No	No	3	5
415	1x60	8x53	nts1_on	0	2.91	No	No	No	No	5	0
416	4x60	4x63	nts1_on	0	2.89	No	No	No	No	8	4
417	5x65	5x68	nts1_on	0	2.83	No	No	No	No	8	6
418	6x32	6x36	nts1_on	0	2.77	Yes	No	No	No	8	8
419	5x68	5x71	nts1_on	0	2.72	No	No	No	No	6	0
420	3x30	4x59	nts1_on	0	2.62	No	Yes	Yes	No	5	4
421	6x34	6x38	nts1_on	0	2.62	No	Yes	No	No	7	5
422	6x57	7x29	nts1_on	0	2.49	No	No	No	No	5	4
423	2x52	4x50	nts1_on	0	2.28	No	No	Yes	Yes	6	9
424	6x33	6x36	nts1_on	0	1.84	No	No	No	No	8	8
425	1x54	2x44	nts1_on	0	1.71	No	No	No	No	7	5
426	1x57	2x44	nts1_on	0	1.71	No	No	No	No	7	5
427	5x72	6x27	nts1_on	0	1.7	No	No	No	No	0	3
428	3x53	3x54	nts1_on	0	1.62	No	No	Yes	No	8	8
429	6x43	7x48	nts1_on	0	1.62	No	No	No	No	5	6
430	2x551	3x35	nts1_on	0	1.59	No	No	No	No	5	7
431	3x52	I2x53	nts1_on	0	1.58	No	No	No	No	4	6
432	6x39	7x52	nts1_on	0	1.58	No	No	No	No	6	8
433	7x51	7x56	nts1_on	0	1.54	No	No	No	No	7	0
434	3x56	I2x50	nts1_on	0	1.53	No	No	No	No	6	9
435	5x72	5x75	nts1_on	0	1.52	No	No	No	No	0	0
436	3x27	3x30	nts1_on	0	1.51	No	No	No	Yes	4	5
437	5x33	Lig	nts1_on	0	1.5	No	No	Yes	Yes	1	0
438	6x40	7x52	nts1_on	0	1.49	No	No	No	No	8	8
439	7x52	7x56	nts1_on	0	1.49	No	No	No	No	8	0
440	8x47	8x49	nts1_on	0	1.49	No	No	No	No	0	0
441	6x57	6x61	nts1_on	0	1.46	No	No	No	No	5	3
442	5x41	5x42	nts1_on	0	1.43	No	No	No	No	6	4
443	5x65	6x30	nts1_on	0	1.38	No	No	No	No	8	8
444	6x26	6x29	nts1_on	0	1.38	Yes	No	No	No	5	6
445	8x47	8x50	nts1_on	0	1.32	No	No	No	Yes	0	0
446	3x56	I2x52	nts1_on	0	1.31	No	No	No	No	6	5
447	1x33	2x66	nts1_on	0	1.23	No	No	No	Yes	5	7
448	6x32	8x51	nts1_on	0	1.13	Yes	No	No	No	8	0

Orange: nodes, hubs and links specific of nts1_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of nts1_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	nts1_off Avg Int. Strength	nts1_on Avg Int. Strength	nts1_off Num Of Links	nts1_on Num Of Links	ConSurf
1	1x39	nts1_off	4.79571	5.47333	7	3	7
2	2x33	nts1_off	2.90375	0	4	0	4
3	2x36	nts1_off	6.07	7.13333	4	3	7
4	2x51	nts1_off	3.6825	4.27333	4	3	8
5	2x62	nts1_off	6.51625	7.32	4	2	4
6	3x29	nts1_off	8.75375	7.3	4	3	5
7	3x32	nts1_off	6.28687	7.39333	8	3	7
8	3x33	nts1_off	8.6625	6.87	4	2	6
9	3x37	nts1_off	8.509	9.38667	5	3	6
10	3x39	nts1_off	4.12625	5.62667	4	3	9
11	3x49	nts1_off	10.8538	6.425	4	2	9
12	3x54	nts1_off	4.56125	3.02	4	2	8
13	4x59	nts1_off	2.055	3.075	4	2	4
14	5x43	nts1_off	8.59625	9.26667	4	3	5
15	5x461	nts1_off	5.09625	6.97	4	1	6
16	5x47	nts1_off	8.41125	6.43333	4	3	8
17	6x26	nts1_off	4.93125	1.38	4	1	5
18	6x32	nts1_off	5.73625	2.68333	4	3	8
19	6x37	nts1_off	5.066	6.945	5	2	8
20	6x44	nts1_off	4.86917	5.92667	6	3	9
21	7x41	nts1_off	8.432	8.32333	5	3	7
22	7x42	nts1_off	8.184	7.85333	5	3	7
23	7x45	nts1_off	4.18	5.11667	4	3	9
24	7x49	nts1_off	3.49417	8.2	6	2	9
25	2x38	Shared	7.611	4.975	5	4	6
26	2x42	Shared	8.66	6.0075	5	4	8
27	2x57	Shared	6.00875	5.198	4	5	7
28	2x60	Shared	7.25583	7.41333	6	6	7
29	2x64	Shared	5.55875	6.73167	4	6	6
30	E1x50	Shared	7.9475	10.36	6	5	9
31	E1x52	Shared	7.194	4.89	5	5	7
32	3x28	Shared	10.0013	5.988	4	5	6
33	3x51	Shared	7.31875	6.212	4	5	8
34	4x50	Shared	7.0025	4.836	4	5	9
35	E2	Shared	9.89167	21.0464	9	11	4
36	E2x52	Shared	4.3875	6.5975	4	4	5
37	6x48	Shared	5.96938	7.238	8	5	8
38	6x51	Shared	7.88833	7.612	6	5	5
39	6x52	Shared	11.3263	7.5875	4	4	7
40	6x54	Shared	10.515	7.89	5	7	5
41	6x55	Shared	6.284	9.6625	5	4	6
42	E3	Shared	6.19625	9.56333	4	6	3
43	7x30	Shared	6.334	8.31	5	4	4
44	7x34	Shared	11.6563	9.164	4	5	4
45	7x38	Shared	5.791	6.698	5	5	6
46	7x53	Shared	5.2725	6.07667	4	6	9
47	Lig	Shared	7.92357	10.2519	14	16	0
48	NT	nts1_on	3.7275	13.436	2	10	0
49	1x43	nts1_on	4.045	4.3975	3	4	6
50	I1	nts1_on	4.9275	10.4071	2	7	5
51	2x50	nts1_on	6.11333	6.53	3	4	9
52	2x66	nts1_on	14.8925	6.1975	2	4	7
53	3x30	nts1_on	5.27167	4.8125	3	4	5
54	3x42	nts1_on	7.85833	5.534	3	5	8
55	4x64	nts1_on	3.8475	4.7725	2	4	4
56	4x65	nts1_on	7.81667	8.1525	3	4	5
57	5x50	nts1_on	2.79833	3.93	3	4	9
58	6x34	nts1_on	2.34	2.99	2	4	7
59	7x37	nts1_on	9.225	5.8575	1	4	5
60	8x50	nts1_on	0	7.23	0	5	0

Orange: nodes, hubs and links specific of nts1_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of nts1_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	nts1_off Recurrence	nts1_on Recurrence	nts1_off Hub1?	nts1_on Hub1?	nts1_off Hub2?	nts1_on Hub2?	ConSurf1	ConSurf2
1	6x44	7x49	nts1_off	20.0679	0	Yes	No	Yes	No	9	9
2	7x45	7x49	nts1_off	14.457	0	Yes	No	Yes	No	9	9
3	1x43	2x57	nts1_off	10.6023	6.52377	No	Yes	Yes	Yes	6	7
4	1x50	2x51	nts1_off	11.3308	0	No	No	Yes	No	9	8
5	2x50	6x44	nts1_off	21.3068	0	No	Yes	Yes	No	9	9
6	2x46	3x39	nts1_off	73.7666	0	No	No	Yes	No	9	9
7	2x46	3x42	nts1_off	73.7432	3.31358	No	No	No	Yes	9	8
8	2x45	3x42	nts1_off	36.5612	7.67261	No	No	No	Yes	9	8
9	2x45	4x46	nts1_off	73.0065	7.14743	No	No	No	No	9	7
10	2x42	4x46	nts1_off	72.4408	6.5008	Yes	Yes	No	No	8	7
11	2x42	3x49	nts1_off	60.1209	4.533	Yes	Yes	Yes	No	8	9
12	2x38	3x49	nts1_off	55.6192	3.94216	Yes	Yes	Yes	No	6	9
13	2x35	2x38	nts1_off	97.6381	0	No	No	Yes	Yes	8	6
14	2x35	6x29	nts1_off	48.4493	0	No	No	No	No	8	6
15	2x36	6x29	nts1_off	22.0697	0	Yes	No	No	No	7	6
16	2x49	4x50	nts1_off	37.8953	0	No	No	Yes	Yes	8	9
17	2x45	4x50	nts1_off	37.1172	0.116525	No	No	Yes	Yes	9	9
18	3x42	4x49	nts1_off	37.2399	0.677816	No	Yes	No	No	8	8
19	3x45	4x49	nts1_off	36.8233	0	No	No	No	No	7	8
20	2x42	3x45	nts1_off	36.437	0.674533	Yes	Yes	No	No	8	7
21	2x42	4x42	nts1_off	56.9201	0	Yes	Yes	No	No	8	7
22	2x38	4x42	nts1_off	55.8799	0.672892	Yes	Yes	No	No	6	7
23	2x34	2x38	nts1_off	12.2289	0	No	No	Yes	Yes	5	6
24	2x33	6x29	nts1_off	24.4868	0	Yes	No	No	No	4	6
25	2x33	6x32	nts1_off	17.1693	0	Yes	No	Yes	No	4	8
26	2x36	6x32	nts1_off	17.1983	0	Yes	No	Yes	No	7	8
27	2x35	6x30	nts1_off	47.9761	0	No	No	No	No	8	8
28	2x43	7x53	nts1_off	26.8142	0	No	No	Yes	Yes	8	9
29	2x39	2x43	nts1_off	26.0789	0	No	No	No	No	8	8
30	2x39	3x46	nts1_off	25.7243	0	No	No	No	No	8	9
31	2x59	3x28	nts1_off	18.6952	1.94975	No	No	Yes	Yes	5	6
32	2x59	E1x52	nts1_off	17.4356	1.41307	No	No	Yes	Yes	5	7
33	E2x52	Lig	nts1_off	12.2579	0	Yes	Yes	Yes	Yes	5	0
34	E2x51	E2x52	nts1_off	11.0866	0.0787776	No	No	Yes	Yes	3	5
35	3x33	4x57	nts1_off	19.1573	0	Yes	No	No	No	6	7
36	3x30	4x57	nts1_off	14.9192	5.63096	No	Yes	No	No	5	7
37	3x30	4x62	nts1_off	10.6699	2.8163	No	Yes	No	No	5	5
38	3x32	6x51	nts1_off	17.1845	4.77097	Yes	No	Yes	Yes	7	5
39	3x37	5x461	nts1_off	11.5612	0	Yes	No	Yes	No	6	6
40	3x36	6x48	nts1_off	20.6694	0.390606	No	No	Yes	Yes	7	8
41	3x36	5x461	nts1_off	19.9685	0	No	No	Yes	No	7	6
42	3x46	6x37	nts1_off	23.1375	0	No	No	Yes	No	9	8
43	3x47	6x37	nts1_off	14.2763	0	No	No	Yes	No	9	8
44	3x54	6x30	nts1_off	24.6537	0	Yes	No	No	No	8	8
45	3x54	5x68	nts1_off	14.8322	0	Yes	No	No	No	8	6
46	6x26	6x30	nts1_off	21.6517	0	Yes	No	No	No	5	8
47	6x26	I2x50	nts1_off	12.3462	0	Yes	No	No	No	5	9
48	5x44	6x56	nts1_off	12.7794	0.86163	No	No	No	No	5	5
49	6x56	6x60	nts1_off	10.6561	0	No	No	No	No	5	5
50	5x47	6x48	nts1_off	11.8964	0	Yes	No	Yes	Yes	8	8
51	6x28	6x32	nts1_off	14.7343	0	No	No	Yes	No	5	8
52	6x32	6x35	nts1_off	14.7343	0	Yes	No	No	No	8	7
53	7x31	Lig	nts1_off	16.1636	0	No	No	Yes	Yes	4	0
54	7x31	7x35	nts1_off	11.4839	0	No	No	No	No	4	4
55	6x54	Lig	nts1_off	23.4631	2.68829	Yes	Yes	Yes	Yes	5	0
56	3x33	5x43	nts1_off	17.0093	5.10249	Yes	No	Yes	No	6	5
57	6x51	6x54	nts1_off	25.6263	2.73424	Yes	Yes	Yes	Yes	5	5
58	1x50	2x50	nts1_off	19.4636	1.64941	No	No	No	Yes	9	9
59	3x28	3x32	nts1_off	23.2865	0	Yes	Yes	Yes	No	6	7
60	6x48	6x51	nts1_off	78.4021	0	Yes	Yes	Yes	Yes	8	5
61	3x32	7x41	nts1_off	14.0403	0	Yes	No	Yes	No	7	7
62	2x42	3x46	nts1_off	10.9293	0	Yes	Yes	No	No	8	9
63	3x39	6x44	nts1_off	11.7088	0	Yes	No	Yes	No	9	9
64	7x41	7x42	Shared	11.6853	94.8663	Yes	No	Yes	No	7	7
65	6x48	7x41	Shared	26.4072	94.4117	Yes	Yes	Yes	No	8	7
66	6x44	6x48	Shared	20.519	11.4113	Yes	No	Yes	Yes	9	8
67	6x48	7x45	Shared	14.3977	11.28	Yes	Yes	Yes	No	8	9
68	3x39	6x48	Shared	100	100	Yes	No	Yes	Yes	9	8
69	2x49	3x39	Shared	38.0953	10.1164	No	No	Yes	No	8	9
70	7x49	7x53	Shared	28.3621	44.2665	Yes	No	Yes	Yes	9	9
71	6x51	6x55	Shared	38.0705	12.8178	Yes	Yes	Yes	Yes	5	6
72	5x43	6x55	Shared	10.5899	20.3361	Yes	No	Yes	Yes	5	6
73	6x55	Lig	Shared	23.6107	10.3625	Yes	Yes	Yes	Yes	6	0
74	3x47	5x57	Shared	12.5338	21.6556	No	No	No	No	9	7
75	5x64	5x68	Shared	12.3669	24.0633	No	No	No	No	5	6
76	2x57	7x42	Shared	10.4934	12.0612	Yes	Yes	Yes	No	7	7
77	2x60	7x42	nts1_on	3.5801	95.1896	Yes	Yes	Yes	No	7	7
78	2x60	2x64	nts1_on	2.92478	40.9611	Yes	Yes	Yes	Yes	7	6
79	2x64	Lig	nts1_on	0	32.696	Yes	Yes	Yes	Yes	6	0
80	Lig	NT	nts1_on	0	13.4382	Yes	Yes	No	Yes	0	0
81	2x60	7x34	nts1_on	0	35.9965	Yes	Yes	Yes	Yes	7	4
82	7x34	Lig	nts1_on	3.14966	31.1516	Yes	Yes	Yes	Yes	4	0
83	2x50	3x39	nts1_on	0	89.7507	No	Yes	Yes	No	9	9
84	7x54	8x50	nts1_on	0	22.1546	No	No	No	Yes	7	0
85	2x43	7x54	nts1_on	0	30.0094	No	No	No	No	8	7
86	2x43	3x46	nts1_on	0	31.0909	No	No	No	No	8	9
87	3x46	7x53	nts1_on	0	32.0658	No	No	Yes	Yes	9	9
88	2x46	7x53	nts1_on	0	47.4126	No	No	Yes	Yes	9	9
89	2x46	2x50	nts1_on	0	44.7441	No	No	No	Yes	9	9
90	2x50	7x49	nts1_on	0	44.6111	No	Yes	Yes	No	9	9
91	1x56	8x50	nts1_on	0	14.5673	No	No	No	Yes	7	0
92	1x60	I1	nts1_on	0	11.1864	No	No	No	Yes	5	5
93	1x60	8x53	nts1_on	0	12.3156	No	No	No	No	5	0
94	1x56	8x53	nts1_on	0	13.4447	No	No	No	No	7	0
95	3x30	4x59	nts1_on	0	14.0552	No	Yes	Yes	No	5	4
96	4x59	4x60	nts1_on	2.1384	16.8568	Yes	No	No	No	4	8
97	4x60	4x63	nts1_on	0	19.655	No	No	No	No	8	4
98	4x63	4x64	nts1_on	0	22.45	No	No	No	Yes	4	4
99	3x37	5x43	nts1_on	0.743612	12.7341	Yes	No	Yes	No	6	5
100	3x43	7x53	nts1_on	0	53.7986	No	No	Yes	Yes	8	9
101	3x47	5x58	nts1_on	0	22.7257	No	No	No	No	9	9
102	5x58	6x41	nts1_on	0	47.6982	No	No	No	No	9	8
103	5x54	6x41	nts1_on	0	51.7815	No	No	No	No	8	8
104	3x43	5x54	nts1_on	0	52.7941	No	No	No	No	8	8
105	3x51	5x57	nts1_on	5.43706	19.5188	Yes	Yes	No	No	8	7
106	3x51	5x61	nts1_on	0	19.8175	Yes	Yes	No	No	8	8
107	5x61	6x37	nts1_on	0	22.8882	No	No	Yes	No	8	8
108	5x58	6x37	nts1_on	3.63529	23.9615	No	No	Yes	No	9	8
109	3x51	3x55	nts1_on	0.910546	28.3386	Yes	Yes	No	No	8	7
110	4x65	Lig	nts1_on	1.1506	12.4846	No	Yes	Yes	Yes	5	0
111	3x55	5x64	nts1_on	0	26.1328	No	No	No	No	7	5
112	5x65	5x68	nts1_on	0	19.6419	No	No	No	No	8	6
113	5x65	6x34	nts1_on	0	11.0322	No	No	No	Yes	8	7
114	6x40	7x52	nts1_on	0	10.2608	No	No	No	No	8	8
115	6x40	7x53	nts1_on	0	11.4014	No	No	Yes	Yes	8	9
116	E2	Lig	nts1_on	0	15.7687	Yes	Yes	Yes	Yes	4	0
117	3x29	4x65	nts1_on	0.423542	11.0518	Yes	No	No	Yes	5	5
118	4x64	4x65	nts1_on	0	18.1172	No	Yes	No	Yes	4	5

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
2x60	2x64	Shared	5.335	4.66	1	1	2	1
2x60	3x28	Shared	6.845	4.49	1	1	2	2
2x60	7x38	Shared	8.625	9.2	1	1	2	2
2x64	2x65	nts1_off	5.025	0	1	1	1	2
2x64	7x34	Shared	8.25	12.38	1	1	1	1
2x64	7x38	nts1_off	3.625	0	1	1	1	2
2x67	E1	nts1_off	7.805	0	0	0	2	1
3x25	E1x50	Shared	4.57	9.14	1	1	2	2
E1x50	E2	nts1_off	4.555	0	1	1	2	1
3x22	3x26	Shared	10.37	14.29	1	1	2	2
3x22	E2	Shared	8.785	8.55	1	1	2	1
3x25	E2	nts1_off	3.545	0	1	1	2	1
3x28	3x29	Shared	13.405	5.96	1	1	2	1
3x29	4x61	nts1_off	2.995	0	1	1	1	2
3x29	4x65	Shared	12.575	10.78	1	1	1	1
3x29	Lig	nts1_off	6.04	0	1	1	1	0
4x61	4x64	nts1_off	4.52	0	0	0	2	2
4x65	E2x52	Shared	5.87	10.06	1	1	1	1
4x65	Lig	Shared	5.005	4.24	1	1	1	0
E2	E2	Shared	22.57	69.07	1	1	1	1
E2	E2x51	Shared	13.18	19.21	1	1	1	2
E2x51	E2x52	Shared	5.25	5.25	1	1	2	1
5x36	E2x52	Shared	3.28	5.3	1	0	1	1
E2x52	Lig	nts1_off	3.15	0	1	0	1	0
5x35	E2	Shared	8.165	3.04	0	0	2	1
5x33	5x37	nts1_off	5.82	0	0	0	1	2
5x36	6x58	nts1_off	9.745	0	1	0	1	1
5x36	Lig	nts1_off	3.56	0	1	0	1	0
5x37	6x59	nts1_off	4.58	0	0	0	2	2
5x40	6x55	nts1_off	5.01	0	1	1	1	1
5x40	6x58	nts1_off	7.535	0	1	1	1	1
5x40	Lig	Shared	4.145	5.71	1	1	1	0
5x43	6x55	Shared	5.425	14.46	1	0	2	1
5x44	6x55	nts1_off	3.88	0	0	0	2	1
6x51	6x54	Shared	7.715	8.23	1	1	2	1
6x51	6x55	Shared	10.805	8.23	1	1	2	1
6x54	7x34	Shared	15.95	11.32	1	1	1	1
6x54	7x37	Shared	9.225	7.76	1	1	1	2
6x54	7x38	nts1_off	9.04	0	1	1	1	2
6x54	Lig	Shared	10.645	4.86	1	1	1	0
6x55	Lig	Shared	6.3	8.5	1	1	1	0
6x57	7x33	nts1_off	4.975	0	0	0	1	2
6x57	Lig	nts1_off	10.43	0	0	0	1	0
6x58	Lig	Shared	20.055	17.32	1	1	1	0
6x61	7x30	nts1_off	3.025	0	1	1	1	1
6x61	Lig	nts1_off	5.085	0	1	1	1	0
7x29	7x30	nts1_off	4.125	0	0	0	2	1
7x30	Lig	Shared	14.32	10.91	1	1	1	0
7x31	7x35	nts1_off	7.88	0	0	1	1	2
7x34	Lig	Shared	17.775	6.04	1	1	1	0
1x31	NT	nts1_off	5.155	0	0	0	2	1
3x26	E2	Shared	3.34	6	1	1	2	1
E3	E3	Shared	7.66	5.72	1	1	1	1
7x26	E3	Shared	5.125	3.42	1	1	2	1
7x30	E3	Shared	4.34	4.82	1	1	1	1
7x26	7x30	nts1_off	5.86	0	1	1	2	1
7x34	7x38	Shared	4.65	10.47	1	1	1	2
7x27	Lig	Shared	2.755	29.24	0	1	1	0
5x34	E2	nts1_off	2.315	0	0	0	2	1
1x30	NT	nts1_off	2.3	0	0	0	2	1
3x21	E1x50	nts1_off	2.11	0	0	0	2	2
7x31	Lig	nts1_off	1.665	0	0	1	1	0
1x31	1x32	nts1_off	0.765	0	0	0	2	2
1x31	7x35	nts1_off	0.765	0	0	0	2	2
7x28	7x31	nts1_off	0.63	0	0	0	2	1
NT	NT	nts1_on	0	10.19	0	1	1	1
E2	NT	nts1_on	0	23.32	1	1	1	1
E1	NT	nts1_on	0	42.56	0	1	1	1
Lig	NT	nts1_on	0	5.86	1	1	0	1
7x27	NT	nts1_on	0	5.05	0	1	1	1
7x31	NT	nts1_on	0	16.61	0	1	1	1
7x28	NT	nts1_on	0	8.08	0	0	2	1
1x32	NT	nts1_on	0	7.51	0	1	2	1
7x32	NT	nts1_on	0	4.99	0	1	2	1
2x60	7x34	nts1_on	0	5.61	1	1	2	1
2x64	E1x50	nts1_on	0	4.01	1	1	1	2
2x64	3x28	nts1_on	0	4.13	1	1	1	2
2x64	3x29	nts1_on	0	5.16	1	1	1	1
2x64	Lig	nts1_on	0	10.05	1	1	1	0
E1	Lig	nts1_on	0	6.78	0	1	1	0
E1x49	E2	nts1_on	0	6.09	0	0	2	1
3x21	E2	nts1_on	0	4.91	0	0	2	1
4x64	4x65	nts1_on	0	7.53	0	1	2	1
4x64	E2	nts1_on	0	6.08	0	1	2	1
E2	Lig	nts1_on	0	16.17	1	1	1	0
6x58	E2x52	nts1_on	0	5.78	1	1	1	1
5x40	6x59	nts1_on	0	8.18	1	1	1	2
6x51	7x38	nts1_on	0	5.81	1	1	2	2
6x54	6x55	nts1_on	0	7.46	1	1	1	1
6x54	7x30	nts1_on	0	11.32	1	1	1	1
6x54	7x33	nts1_on	0	4.28	1	1	1	2
6x58	7x30	nts1_on	0	6.19	1	1	1	1
6x61	E3	nts1_on	0	17.23	1	1	1	1
E3	Lig	nts1_on	0	20.47	1	1	1	0
7x27	7x31	nts1_on	0	18.51	0	1	1	1
7x33	7x37	nts1_on	0	7.78	0	1	2	2
7x37	7x38	nts1_on	0	4.39	0	1	2	2
6x57	7x29	nts1_on	0	2.49	0	0	1	2
5x33	Lig	nts1_on	0	1.5	0	0	1	0
6x57	6x61	nts1_on	0	1.46	0	0	1	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	nts1_off	6Z4Q-NTS₁-SR142948A 6Z4S-NTS₁-SR48692
	nts1_on	6OS9-NTS₁-JMV449-Gi1/&β;1/&γ;2

Network Difference
Value	nts1_off	nts1_on
I_min	2.92	3.59
Number of Linked Nodes	252	249
Number of Specific Nodes	17 (6.75%)	14 (5.62%)
Number of Shared Nodes	235 (93.25%)	235 (94.38%)
Number of Links	310	288
Number of Specific Links	160 (51.61%)	138 (47.92%)
Number of Shared Links	150 (48.39%)	150 (52.08%)
Number of Hubs	47	36
Number of Specific Hubs	24 (51.06%)	13 (36.11%)
Number of Shared Hubs	23 (48.94%)	23 (63.89%)
Average % Shared Neighbours (Jaccard)	35.74
Average % Shared Neighbours (Otsuka)	44.42
Average % Shared Neighbours (Overlap Coefficient)	52.67
Average % Shared Cliques (k3-6)	77.31
Graphlets Similarity	0.609502

Paths Difference
Value	nts1_off	nts1_on
Number Of Nodes in MetaPath	69	53
Specific Nodes in MetaPath	44 (63.77%)	28 (52.83%)
Shared Nodes in MetaPath	235 (93.25%)	235 (93.25%)
Number Of Links MetaPath	76	55
Specific Links in MetaPath	63 (82.89%)	42 (76.36%)
Shared Links in MetaPath	150 (48.39%)	150 (48.39%)
Number of Shortest Paths	138376	86258
Length Of Smallest Path	3	3
Average Path Length	15.6186	16.6814
Length of Longest Path	28	32
Minimum Path Strength	0.6675	1.28
Average Path Strength	6.0746	6.61961
Maximum Path Strength	16.2825	29.585
Minimum Path Correlation	0.7	0.7
Average Path Correlation	0.91155	0.926527
Maximum Path Correlation	0.99	0.99
Minimum % Of Corr. Nodes	5	4.16667
Average % Of Corr. Nodes	34.4203	46.1985
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	48.9925	39.3245
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

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