psnGPCR

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Orange: nodes, hubs and links specific of opioid_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of opioid_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	opioid_off Int. Strength	opioid_on Int. Strength	opioid_off Hub1?	opioid_on Hub1?	opioid_off Hub2?	opioid_on Hub2?	ConSurf1	ConSurf2
1	1x39	2x57	opioid_off	100	0	Yes	Yes	Yes	No	6	7
2	1x50	2x47	opioid_off	100	0	Yes	No	No	No	9	8
3	1x53	7x53	opioid_off	100	0	No	No	Yes	Yes	9	9
4	1x56	8x53	opioid_off	100	0	No	No	No	No	8	6
5	2x40	I1x50	opioid_off	100	0	No	No	No	No	7	7
6	8x50	I1x50	opioid_off	100	0	Yes	Yes	No	No	8	7
7	2x38	3x49	opioid_off	100	0	No	No	No	No	6	8
8	2x39	3x50	opioid_off	100	0	No	No	Yes	No	8	9
9	2x39	6x33	opioid_off	100	0	No	No	No	No	8	7
10	2x41	4x42	opioid_off	100	0	Yes	No	No	No	5	7
11	2x42	4x45	opioid_off	100	0	Yes	Yes	No	No	7	6
12	2x43	7x53	opioid_off	100	0	No	No	Yes	Yes	8	9
13	2x45	4x49	opioid_off	100	0	Yes	No	No	No	9	7
14	2x46	7x53	opioid_off	100	0	No	No	Yes	Yes	9	9
15	2x52	3x31	opioid_off	100	0	No	No	No	No	6	5
16	2x56	3x31	opioid_off	100	0	No	No	No	No	7	5
17	2x59	3x24	opioid_off	100	0	No	No	No	No	5	5
18	2x66	E1x49	opioid_off	100	0	No	No	No	No	4	4
19	3x28	E1x50	opioid_off	100	0	No	No	Yes	Yes	6	8
20	3x30	3x34	opioid_off	100	0	No	No	Yes	Yes	5	5
21	3x34	4x57	opioid_off	100	0	Yes	Yes	No	No	5	6
22	3x35	3x39	opioid_off	100	0	No	Yes	No	No	8	9
23	3x36	6x52	opioid_off	100	0	No	No	No	Yes	7	8
24	3x37	3x41	opioid_off	100	0	Yes	No	No	No	6	6
25	3x37	5x461	opioid_off	100	0	Yes	No	No	No	6	6
26	3x39	6x44	opioid_off	100	0	No	No	Yes	No	9	9
27	3x40	6x44	opioid_off	100	0	No	No	Yes	No	7	9
28	3x42	4x49	opioid_off	100	0	No	No	No	No	7	7
29	3x43	6x41	opioid_off	100	0	No	No	No	No	8	8
30	3x43	6x44	opioid_off	100	0	No	No	Yes	No	8	9
31	3x44	5x54	opioid_off	100	0	No	No	No	No	7	8
32	3x46	6x37	opioid_off	100	0	No	No	No	No	8	8
33	3x50	3x53	opioid_off	100	0	Yes	No	No	No	9	8
34	3x50	6x33	opioid_off	100	0	Yes	No	No	No	9	7
35	3x50	6x34	opioid_off	100	0	Yes	No	No	No	9	6
36	3x50	6x37	opioid_off	100	0	Yes	No	No	No	9	8
37	3x51	5x61	opioid_off	100	0	Yes	Yes	No	No	7	8
38	3x51	5x64	opioid_off	100	0	Yes	Yes	No	No	7	5
39	5x32	5x36	opioid_off	100	0	No	No	No	No	1	4
40	5x40	6x55	opioid_off	100	0	Yes	No	No	No	4	5
41	5x54	6x41	opioid_off	100	0	No	No	No	No	8	8
42	5x58	6x38	opioid_off	100	0	Yes	Yes	No	No	8	4
43	I3	I3	opioid_off	100	0	Yes	Yes	Yes	Yes	4	4
44	6x32	6x35	opioid_off	100	0	No	No	No	No	7	6
45	6x36	8x47	opioid_off	100	0	No	No	No	No	8	8
46	6x39	7x56	opioid_off	100	0	No	No	No	No	5	7
47	6x48	6x51	opioid_off	100	0	Yes	Yes	No	No	8	6
48	6x48	Lig	opioid_off	100	0	Yes	Yes	Yes	Yes	8	0
49	6x50	7x37	opioid_off	100	0	No	No	No	No	9	7
50	6x54	7x37	opioid_off	100	0	No	No	No	No	5	7
51	7x34	7x35	opioid_off	100	0	Yes	No	No	Yes	4	4
52	7x42	Lig	opioid_off	100	0	Yes	No	Yes	Yes	6	0
53	1x35	1x39	opioid_off	100	0	No	Yes	Yes	Yes	5	6
54	2x56	3x28	opioid_off	100	0	No	No	No	No	7	6
55	6x28	6x32	opioid_off	100	0	No	No	No	No	4	7
56	1x52	8x54	opioid_off	50	0	No	No	Yes	No	6	6
57	5x42	5x46	opioid_off	58.3333	0	No	No	No	No	3	4
58	3x55	3x56	opioid_off	33.3333	0	No	No	No	No	7	6
59	1x46	2x54	opioid_off	25	0	No	No	No	No	8	6
60	1x42	2x57	opioid_off	33.3333	0	Yes	No	Yes	No	7	7
61	5x67	6x25	opioid_off	25	0	No	No	No	No	4	3
62	1x60	8x53	opioid_off	58.3333	0	Yes	No	No	No	5	6
63	6x58	7x34	opioid_off	41.6667	0	No	No	Yes	No	5	4
64	6x40	7x49	opioid_off	50	0	No	No	Yes	No	8	9
65	5x66	6x25	opioid_off	25	0	No	No	No	No	4	3
66	1x55	8x57	opioid_off	50	0	No	No	No	No	4	4
67	6x47	7x40	opioid_off	41.6667	0	No	No	No	No	8	8
68	5x66	6x27	opioid_off	25	0	No	No	No	No	4	3
69	I1x48	I1x51	opioid_off	33.3333	0	No	No	No	No	6	7
70	5x67	I3	opioid_off	25	0	No	No	Yes	Yes	4	4
71	2x54	7x46	opioid_off	25	0	No	No	No	No	6	8
72	1x52	8x57	opioid_off	50	0	No	No	No	No	6	4
73	8x48	8x52	opioid_off	25	0	No	No	No	No	4	5
74	6x24	I3	opioid_off	50	0	No	No	Yes	Yes	3	4
75	3x48	5x57	opioid_off	8.33333	0	No	No	No	No	6	7
76	6x26	6x27	opioid_off	25	0	No	No	No	No	4	3
77	5x46	5x49	opioid_off	8.33333	0	No	No	No	No	4	5
78	1x31	NT	opioid_off	25	0	No	No	No	No	4	2
79	6x31	6x34	opioid_off	25	0	No	No	No	No	5	6
80	6x57	6x61	opioid_off	25	0	No	No	No	No	4	2
81	6x31	I3	opioid_off	50	0	No	No	Yes	Yes	5	4
82	5x31	5x34	opioid_off	33.3333	0	No	No	No	No	4	1
83	1x60	I1x48	opioid_off	33.3333	0	Yes	No	No	No	5	6
84	6x43	7x45	opioid_off	8.33333	0	No	No	Yes	Yes	7	9
85	6x45	6x49	opioid_off	8.33333	0	No	No	No	No	6	5
86	5x51	5x55	opioid_off	0	0	No	No	No	No	6	5
87	3x50	6x30	opioid_off	16.6667	0	Yes	No	No	Yes	9	6
88	2x41	4x39	opioid_off	0	0	Yes	No	No	No	5	2
89	I1x48	I1x49	opioid_off	33.3333	0	No	No	No	No	6	5
90	5x37	5x41	opioid_off	25	0	No	No	No	No	3	5
91	5x31	5x33	opioid_off	33.3333	0	No	No	No	No	4	2
92	I2x55	I2x57	opioid_off	25	0	No	No	No	No	4	6
93	1x38	1x42	opioid_off	8.33333	0	No	No	Yes	No	5	7
94	1x60	8x56	opioid_off	41.6667	0	Yes	No	No	No	5	3
95	8x54	8x55	opioid_off	25	0	Yes	No	No	No	6	5
96	1x31	1x32	opioid_off	25	0	No	No	No	No	4	4
97	1x47	2x55	opioid_off	16.6667	0	No	No	No	No	6	4
98	7x55	7x56	opioid_off	8.33333	0	No	No	No	No	6	7
99	1x32	2x65	opioid_off	0	0	No	No	No	No	4	4
100	6x27	6x29	opioid_off	25	0	No	No	No	No	3	5
101	7x54	8x54	opioid_off	8.33333	0	No	No	Yes	No	7	6
102	8x58	8x59	opioid_off	8.33333	0	No	No	No	No	5	4
103	2x67	E2	opioid_off	25	0	No	No	Yes	Yes	5	3
104	3x23	3x24	opioid_off	0	0	No	No	No	No	1	5
105	5x48	5x52	opioid_off	0	0	No	No	No	No	4	3
106	6x41	6x42	opioid_off	0	0	No	No	No	No	8	5
107	7x28	NT	opioid_off	25	0	No	No	No	No	0	2
108	1x29	1x32	opioid_off	0	0	No	No	No	No	0	4
109	1x33	2x65	opioid_off	0	0	No	No	No	No	5	4
110	6x57	E3	opioid_off	16.6667	0	No	No	No	Yes	4	2
111	7x32	7x33	opioid_off	0	0	No	No	No	No	2	4
112	1x44	1x48	opioid_off	0	0	No	No	No	No	5	4
113	1x25	1x29	opioid_off	0	0	No	No	No	No	0	0
114	8x57	8x58	opioid_off	0	0	No	No	No	No	4	5
115	4x61	4x62	opioid_off	8.33333	0	No	No	No	No	4	4
116	6x45	6x46	opioid_off	0	0	No	No	No	No	6	6
117	5x59	5x62	opioid_off	0	0	No	No	No	No	4	5
118	5x62	5x66	opioid_off	8.33333	0	No	No	No	No	5	4
119	1x27	1x28	opioid_off	0	0	No	No	No	No	0	0
120	8x59	CT	opioid_off	0	0	No	No	No	No	4	4
121	1x28	2x67	opioid_off	0	0	No	No	No	No	0	5
122	4x41	4x44	opioid_off	0	0	No	No	No	No	5	3
123	I2x50	I2x51	opioid_off	0	0	No	No	No	No	8	5
124	1x39	2x61	Shared	100	37.5	Yes	Yes	No	No	6	6
125	1x42	7x47	Shared	100	50	Yes	No	No	No	7	7
126	1x43	2x58	Shared	100	100	No	Yes	No	No	7	8
127	1x47	2x54	Shared	100	100	No	No	No	No	6	6
128	1x49	7x50	Shared	100	21.875	No	No	No	No	7	9
129	1x50	2x50	Shared	100	100	Yes	No	No	Yes	9	9
130	1x50	7x50	Shared	100	100	Yes	No	No	No	9	9
131	1x54	2x44	Shared	100	100	No	No	No	Yes	7	5
132	1x54	2x48	Shared	100	100	No	No	No	No	7	6
133	1x55	1x59	Shared	100	100	No	No	No	No	4	5
134	1x57	8x50	Shared	100	31.25	No	No	Yes	Yes	7	8
135	1x58	2x44	Shared	100	56.25	No	No	No	Yes	3	5
136	1x59	1x60	Shared	100	100	No	No	Yes	No	5	5
137	2x37	2x40	Shared	100	100	No	No	No	No	7	7
138	2x40	8x50	Shared	100	37.5	No	No	Yes	Yes	7	8
139	2x41	4x46	Shared	100	78.125	Yes	No	No	No	5	7
140	2x42	3x45	Shared	100	100	Yes	Yes	No	No	7	6
141	2x42	3x46	Shared	100	100	Yes	Yes	No	No	7	8
142	2x42	3x49	Shared	100	100	Yes	Yes	No	No	7	8
143	2x42	4x42	Shared	100	100	Yes	Yes	No	No	7	7
144	2x42	4x46	Shared	100	100	Yes	Yes	No	No	7	7
145	2x45	3x42	Shared	100	100	Yes	No	No	No	9	7
146	2x45	4x46	Shared	100	100	Yes	No	No	No	9	7
147	2x45	4x50	Shared	100	100	Yes	No	Yes	Yes	9	9
148	2x46	3x42	Shared	100	100	No	No	No	No	9	7
149	2x48	4x50	Shared	100	62.5	No	No	Yes	Yes	6	9
150	2x50	7x46	Shared	100	100	No	Yes	No	No	9	8
151	2x50	7x49	Shared	100	100	No	Yes	Yes	No	9	9
152	2x53	3x35	Shared	100	28.125	No	No	No	Yes	7	8
153	2x57	7x42	Shared	100	100	Yes	No	Yes	No	7	6
154	2x59	E1x52	Shared	100	100	No	No	Yes	Yes	5	7
155	2x60	7x42	Shared	100	100	No	No	Yes	No	7	6
156	2x60	Lig	Shared	100	100	No	No	Yes	Yes	7	0
157	2x62	E1x52	Shared	100	100	No	No	Yes	Yes	4	7
158	2x63	E1x50	Shared	100	100	No	No	Yes	Yes	5	8
159	2x64	7x35	Shared	100	100	No	No	No	Yes	4	4
160	2x66	E1x51	Shared	100	100	No	No	No	No	4	1
161	E1x49	E2	Shared	100	100	No	No	Yes	Yes	4	3
162	E1x50	E1x52	Shared	100	100	Yes	Yes	Yes	Yes	8	7
163	3x25	E1x50	Shared	100	100	No	No	Yes	Yes	9	8
164	E1x50	E2x50	Shared	100	100	Yes	Yes	No	No	8	9
165	E1x51	E1x52	Shared	100	100	No	No	Yes	Yes	1	7
166	3x24	E1x52	Shared	100	100	No	No	Yes	Yes	5	7
167	3x22	E2	Shared	100	100	No	No	Yes	Yes	2	3
168	3x25	E2x50	Shared	100	100	No	No	No	No	9	9
169	3x30	4x61	Shared	100	100	No	No	No	No	5	4
170	3x32	Lig	Shared	100	100	No	No	Yes	Yes	6	0
171	3x33	4x60	Shared	100	100	No	No	No	No	5	5
172	3x33	Lig	Shared	100	100	No	No	Yes	Yes	5	0
173	3x34	4x50	Shared	100	100	Yes	Yes	Yes	Yes	5	9
174	3x34	4x54	Shared	100	100	Yes	Yes	No	No	5	4
175	3x36	6x48	Shared	100	100	No	No	Yes	Yes	7	8
176	3x36	Lig	Shared	100	100	No	No	Yes	Yes	7	0
177	3x37	4x56	Shared	100	100	Yes	No	No	No	6	5
178	3x37	5x43	Shared	100	100	Yes	No	No	No	6	5
179	3x38	4x50	Shared	100	100	No	Yes	Yes	Yes	7	9
180	3x40	5x50	Shared	100	100	No	No	No	No	7	9
181	3x41	4x49	Shared	100	31.25	No	No	No	No	6	7
182	3x41	4x52	Shared	100	9.375	No	No	No	No	6	4
183	3x45	4x45	Shared	100	53.125	No	No	No	No	6	6
184	3x47	5x54	Shared	100	100	No	No	No	No	9	8
185	3x47	5x58	Shared	100	100	No	No	Yes	Yes	9	8
186	3x51	5x60	Shared	100	100	Yes	Yes	No	No	7	4
187	3x54	5x61	Shared	100	100	No	No	No	No	8	8
188	3x55	5x64	Shared	100	46.875	No	No	No	No	7	5
189	3x56	I2x52	Shared	100	9.375	No	No	No	No	6	4
190	4x38	4x39	Shared	100	28.125	No	No	No	No	7	2
191	E2	E2	Shared	100	100	Yes	Yes	Yes	Yes	3	3
192	E2	E2x51	Shared	100	100	Yes	Yes	No	No	3	4
193	5x32	E2	Shared	100	100	No	No	Yes	Yes	1	3
194	5x35	E2	Shared	100	100	No	No	Yes	Yes	7	3
195	5x36	E2	Shared	100	100	No	No	Yes	Yes	4	3
196	5x39	E2	Shared	100	100	No	No	Yes	Yes	5	3
197	5x34	5x35	Shared	100	100	No	No	No	No	1	7
198	5x34	5x38	Shared	100	100	No	No	No	No	1	4
199	5x36	5x40	Shared	100	100	No	No	Yes	No	4	4
200	5x40	Lig	Shared	100	100	Yes	No	Yes	Yes	4	0
201	5x43	Lig	Shared	100	100	No	No	Yes	Yes	5	0
202	5x44	5x48	Shared	100	100	No	Yes	No	No	5	4
203	5x44	6x56	Shared	100	100	No	Yes	No	No	5	5
204	5x45	5x46	Shared	100	37.5	No	No	No	No	5	4
205	5x47	5x51	Shared	100	100	Yes	Yes	No	No	8	6
206	5x47	6x49	Shared	100	100	Yes	Yes	No	No	8	5
207	5x47	6x52	Shared	100	100	Yes	Yes	No	Yes	8	8
208	5x49	5x50	Shared	100	100	No	No	No	No	5	9
209	5x58	5x61	Shared	100	100	Yes	Yes	No	No	8	8
210	5x58	6x37	Shared	100	100	Yes	Yes	No	No	8	8
211	6x32	8x48	Shared	100	100	No	No	No	No	7	4
212	6x36	7x56	Shared	100	100	No	No	No	No	8	7
213	6x44	6x48	Shared	100	100	Yes	No	Yes	Yes	9	8
214	6x44	7x45	Shared	100	100	Yes	No	Yes	Yes	9	9
215	6x47	7x45	Shared	100	100	No	No	Yes	Yes	8	9
216	6x48	7x41	Shared	100	9.375	Yes	Yes	No	No	8	7
217	6x48	7x45	Shared	100	100	Yes	Yes	Yes	Yes	8	9
218	6x51	Lig	Shared	100	100	No	No	Yes	Yes	6	0
219	6x52	Lig	Shared	100	100	No	Yes	Yes	Yes	8	0
220	6x54	7x34	Shared	100	100	No	No	Yes	No	5	4
221	6x55	Lig	Shared	100	100	No	No	Yes	Yes	5	0
222	7x31	7x35	Shared	100	25	No	No	No	Yes	4	4
223	7x34	7x38	Shared	100	100	Yes	No	No	No	4	5
224	7x38	Lig	Shared	100	100	No	No	Yes	Yes	5	0
225	7x45	7x49	Shared	100	100	Yes	Yes	Yes	No	9	9
226	7x49	7x53	Shared	100	100	Yes	No	Yes	Yes	9	9
227	8x47	8x49	Shared	100	100	No	No	No	No	8	6
228	8x47	8x50	Shared	100	100	No	No	Yes	Yes	8	8
229	1x36	2x61	Shared	100	100	No	No	No	No	5	6
230	1x36	2x65	Shared	100	100	No	No	No	No	5	4
231	3x32	7x42	Shared	100	100	No	No	Yes	No	6	6
232	3x49	I2x57	Shared	100	100	No	No	No	No	8	6
233	3x51	3x55	Shared	100	100	Yes	Yes	No	No	7	7
234	6x58	E3	Shared	100	100	No	No	No	Yes	5	2
235	E2	Lig	Shared	100	100	Yes	Yes	Yes	Yes	3	0
236	Lig	Lig	Shared	100	100	Yes	Yes	Yes	Yes	0	0
237	6x43	7x52	Shared	33.3333	50	No	No	No	No	7	8
238	3x51	5x57	Shared	66.6667	100	Yes	Yes	No	No	7	7
239	1x57	2x44	Shared	41.6667	100	No	No	No	Yes	7	5
240	5x68	I3	Shared	33.3333	100	No	No	Yes	Yes	6	4
241	1x43	2x57	Shared	33.3333	100	No	Yes	Yes	No	7	7
242	7x27	7x29	Shared	50	25	No	No	No	No	0	4
243	3x29	Lig	Shared	33.3333	100	No	No	Yes	Yes	4	0
244	8x49	8x52	Shared	50	34.375	No	No	No	No	6	5
245	3x38	4x53	Shared	50	100	No	Yes	No	No	7	8
246	4x54	4x58	Shared	25	31.25	No	No	No	No	4	4
247	8x50	8x54	Shared	33.3333	25	Yes	Yes	Yes	No	8	6
248	4x38	4x41	Shared	50	100	No	No	No	No	7	5
249	1x42	7x43	Shared	8.33333	50	Yes	No	No	No	7	5
250	3x54	5x65	Shared	66.6667	100	No	No	No	No	8	8
251	4x63	E2	Shared	33.3333	100	No	No	Yes	Yes	4	3
252	3x33	E2x52	Shared	16.6667	31.25	No	No	No	No	5	4
253	3x44	5x53	Shared	25	100	No	No	No	No	7	6
254	2x49	3x38	Shared	0	40.625	No	No	No	Yes	8	7
255	2x41	4x43	Shared	8.33333	43.75	Yes	No	No	No	5	4
256	4x58	4x59	Shared	25	53.125	No	No	No	No	4	7
257	3x21	E1x50	Shared	0	25	No	No	Yes	Yes	7	8
258	4x38	4x40	Shared	25	0	No	No	No	No	7	4
259	3x22	3x26	Shared	41.6667	100	No	No	No	No	2	6
260	5x44	5x47	Shared	41.6667	100	No	Yes	Yes	Yes	5	8
261	3x52	I2x56	Shared	33.3333	100	No	No	No	Yes	5	4
262	7x27	7x30	Shared	50	25	No	No	No	No	0	3
263	7x30	E3	Shared	25	100	No	No	No	Yes	3	2
264	3x26	4x64	Shared	25	53.125	No	No	No	No	6	4
265	1x35	7x36	Shared	25	25	No	Yes	No	No	5	5
266	5x60	5x63	Shared	33.3333	25	No	No	No	No	4	4
267	5x40	6x59	Shared	25	100	Yes	No	No	No	4	4
268	6x54	7x33	Shared	25	50	No	No	No	No	5	4
269	8x48	8x51	Shared	25	100	No	No	No	No	4	8
270	1x45	1x46	Shared	8.33333	0	No	No	No	No	5	8
271	7x43	7x48	Shared	25	31.25	No	No	No	No	5	6
272	1x50	2x51	Shared	0	100	Yes	No	No	No	9	8
273	4x41	I2x56	Shared	33.3333	50	No	No	No	Yes	5	4
274	1x48	1x49	Shared	25	6.25	No	No	No	No	4	7
275	6x56	6x60	Shared	25	0	No	No	No	No	5	4
276	3x27	3x31	Shared	0	28.125	No	No	No	No	5	5
277	6x23	6x26	Shared	33.3333	100	No	No	No	No	0	4
278	4x47	4x51	Shared	33.3333	6.25	No	No	No	No	4	4
279	5x41	5x45	Shared	8.33333	28.125	No	No	No	No	5	5
280	5x56	5x60	Shared	0	6.25	No	No	No	No	4	4
281	3x56	I2x50	Shared	0	0	No	No	No	No	6	8
282	7x51	7x55	Shared	0	100	No	No	No	No	7	6
283	6x49	6x53	Shared	0	6.25	No	No	No	No	5	5
284	1x39	7x39	Shared	0	50	Yes	Yes	No	No	6	5
285	1x36	1x40	Shared	0	0	No	No	No	No	5	4
286	1x30	1x33	Shared	16.6667	25	No	No	No	No	4	5
287	1x37	1x40	Shared	25	25	No	No	No	No	5	4
288	1x30	1x34	Shared	0	0	No	No	No	No	4	5
289	I2x54	I2x55	Shared	8.33333	0	No	No	No	No	5	4
290	I2x53	I2x57	Shared	0	6.25	No	No	No	No	5	6
291	4x44	4x48	Shared	0	0	No	No	No	No	3	4
292	1x47	1x51	Shared	8.33333	31.25	No	No	No	No	6	4
293	1x41	1x45	Shared	0	0	No	No	No	No	5	5
294	4x55	4x56	Shared	0	6.25	No	No	No	No	4	5
295	1x35	2x64	opioid_on	0	100	No	Yes	No	No	5	4
296	1x39	7x35	opioid_on	0	100	Yes	Yes	No	Yes	6	4
297	1x39	7x38	opioid_on	0	100	Yes	Yes	No	No	6	5
298	1x43	1x47	opioid_on	0	100	No	Yes	No	No	7	6
299	1x53	7x54	opioid_on	0	100	No	No	No	No	9	7
300	1x56	1x60	opioid_on	0	100	No	No	Yes	No	8	5
301	1x56	8x50	opioid_on	0	100	No	No	Yes	Yes	8	8
302	2x40	I1x48	opioid_on	0	100	No	No	No	No	7	6
303	2x44	I1x50	opioid_on	0	100	No	Yes	No	No	5	7
304	2x46	2x50	opioid_on	0	100	No	No	No	Yes	9	9
305	2x46	3x43	opioid_on	0	100	No	No	No	No	9	8
306	2x50	3x39	opioid_on	0	100	No	Yes	No	No	9	9
307	2x52	3x35	opioid_on	0	100	No	No	No	Yes	6	8
308	2x56	2x60	opioid_on	0	100	No	No	No	No	7	7
309	2x56	3x32	opioid_on	0	100	No	No	No	No	7	6
310	2x59	3x28	opioid_on	0	100	No	No	No	No	5	6
311	3x34	3x38	opioid_on	0	100	Yes	Yes	No	Yes	5	7
312	3x34	4x53	opioid_on	0	100	Yes	Yes	No	No	5	8
313	3x40	6x48	opioid_on	0	100	No	No	Yes	Yes	7	8
314	3x43	7x53	opioid_on	0	100	No	No	Yes	Yes	8	9
315	3x44	5x50	opioid_on	0	100	No	No	No	No	7	9
316	3x45	4x49	opioid_on	0	100	No	No	No	No	6	7
317	3x46	7x53	opioid_on	0	100	No	No	Yes	Yes	8	9
318	3x50	5x58	opioid_on	0	100	Yes	No	Yes	Yes	9	8
319	3x50	7x53	opioid_on	0	100	Yes	No	Yes	Yes	9	9
320	3x51	3x56	opioid_on	0	100	Yes	Yes	No	No	7	6
321	3x53	I2x57	opioid_on	0	100	No	No	No	No	8	6
322	E2x50	Lig	opioid_on	0	100	No	No	Yes	Yes	9	0
323	5x31	E2	opioid_on	0	100	No	No	Yes	Yes	4	3
324	5x44	6x52	opioid_on	0	100	No	Yes	No	Yes	5	8
325	5x51	6x44	opioid_on	0	100	No	No	Yes	No	6	9
326	5x54	5x58	opioid_on	0	100	No	No	Yes	Yes	8	8
327	5x62	6x34	opioid_on	0	100	No	No	No	No	5	6
328	5x65	I3	opioid_on	0	100	No	No	Yes	Yes	8	4
329	6x30	I3	opioid_on	0	100	No	Yes	Yes	Yes	6	4
330	6x25	6x28	opioid_on	0	100	No	No	No	No	3	4
331	6x29	6x32	opioid_on	0	100	No	No	No	No	5	7
332	6x31	6x35	opioid_on	0	100	No	No	No	No	5	6
333	6x40	7x53	opioid_on	0	100	No	No	Yes	Yes	8	9
334	6x48	6x52	opioid_on	0	100	Yes	Yes	No	Yes	8	8
335	6x49	6x50	opioid_on	0	100	No	No	No	No	5	9
336	6x54	6x58	opioid_on	0	100	No	No	No	No	5	5
337	6x58	Lig	opioid_on	0	100	No	No	Yes	Yes	5	0
338	7x34	Lig	opioid_on	0	100	Yes	No	Yes	Yes	4	0
339	1x35	7x35	opioid_on	0	100	No	Yes	No	Yes	5	4
340	5x461	6x52	opioid_on	0	100	No	No	No	Yes	6	8
341	E2	E3	opioid_on	0	100	Yes	Yes	No	Yes	3	2
342	E3	E3	opioid_on	0	100	No	Yes	No	Yes	2	2
343	2x63	Lig	opioid_on	0	100	No	No	Yes	Yes	5	0
344	E3	Lig	opioid_on	0	100	No	Yes	Yes	Yes	2	0
345	1x60	8x57	opioid_on	0	100	Yes	No	No	No	5	4
346	5x33	5x34	opioid_on	0	100	No	No	No	No	2	1
347	5x45	5x48	opioid_on	0	78.125	No	No	No	No	5	4
348	3x34	3x35	opioid_on	0	65.625	Yes	Yes	No	Yes	5	8
349	1x46	7x47	opioid_on	0	56.25	No	No	No	No	8	7
350	3x31	3x35	opioid_on	0	75	No	No	No	Yes	5	8
351	5x51	6x45	opioid_on	0	62.5	No	No	No	No	6	6
352	5x58	6x41	opioid_on	0	18.75	Yes	Yes	No	No	8	8
353	6x51	7x37	opioid_on	0	75	No	No	No	No	6	7
354	2x43	3x46	opioid_on	0	40.625	No	No	No	No	8	8
355	1x53	2x47	opioid_on	0	37.5	No	No	No	No	9	8
356	1x53	1x57	opioid_on	0	53.125	No	No	No	No	9	7
357	6x30	6x34	opioid_on	0	56.25	No	Yes	No	No	6	6
358	7x55	8x50	opioid_on	0	56.25	No	No	Yes	Yes	6	8
359	3x48	3x52	opioid_on	0	31.25	No	No	No	No	6	5
360	1x31	7x32	opioid_on	0	34.375	No	No	No	No	4	2
361	7x36	7x40	opioid_on	0	34.375	No	No	No	No	5	8
362	7x48	7x52	opioid_on	0	34.375	No	No	No	No	6	8
363	1x31	1x35	opioid_on	0	50	No	No	No	Yes	4	5
364	2x39	2x43	opioid_on	0	40.625	No	No	No	No	8	8
365	1x38	7x39	opioid_on	0	50	No	No	No	No	5	5
366	6x40	7x52	opioid_on	0	50	No	No	No	No	8	8
367	5x38	5x42	opioid_on	0	25	No	No	No	No	4	3
368	5x64	5x67	opioid_on	0	9.375	No	No	No	No	5	4
369	6x26	I3	opioid_on	0	53.125	No	No	Yes	Yes	4	4
370	5x64	5x68	opioid_on	0	50	No	No	No	No	5	6
371	3x49	I2x56	opioid_on	0	31.25	No	No	No	Yes	8	4
372	6x61	E3	opioid_on	0	25	No	No	No	Yes	2	2
373	5x55	6x41	opioid_on	0	6.25	No	No	No	No	5	8
374	6x29	6x33	opioid_on	0	31.25	No	No	No	No	5	7
375	8x53	I1x48	opioid_on	0	31.25	No	No	No	No	6	6
376	2x38	4x42	opioid_on	0	0	No	No	No	No	6	7
377	4x39	I1x51	opioid_on	0	31.25	No	No	No	No	2	7
378	4x40	4x44	opioid_on	0	37.5	No	No	No	No	4	3
379	6x34	6x38	opioid_on	0	31.25	No	No	No	No	6	4
380	7x27	7x28	opioid_on	0	25	No	No	No	No	0	0
381	4x56	4x57	opioid_on	0	0	No	No	No	No	5	6
382	6x32	6x36	opioid_on	0	31.25	No	No	No	No	7	8
383	5x66	6x30	opioid_on	0	25	No	No	No	Yes	4	6
384	6x27	6x31	opioid_on	0	25	No	No	No	No	3	5
385	4x58	4x62	opioid_on	0	25	No	No	No	No	4	4
386	5x37	6x59	opioid_on	0	25	No	No	No	No	3	4
387	5x65	6x33	opioid_on	0	0	No	No	No	No	8	7
388	1x52	7x55	opioid_on	0	18.75	No	No	No	No	6	6
389	8x51	8x55	opioid_on	0	28.125	No	No	No	No	8	5
390	8x56	8x57	opioid_on	0	3.125	No	No	No	No	3	4
391	6x53	6x57	opioid_on	0	3.125	No	No	No	No	5	4
392	2x52	2x55	opioid_on	0	0	No	No	No	No	6	4
393	5x52	5x56	opioid_on	0	25	No	No	No	No	3	4
394	I1x49	I1x51	opioid_on	0	25	No	No	No	No	5	7
395	1x32	2x64	opioid_on	0	3.125	No	No	No	No	4	4
396	I2x55	I2x56	opioid_on	0	25	No	No	No	Yes	4	4
397	6x23	6x25	opioid_on	0	6.25	No	No	No	No	0	3
398	3x30	4x57	opioid_on	0	0	No	No	No	No	5	6
399	6x27	6x30	opioid_on	0	25	No	No	No	Yes	3	6
400	6x39	6x43	opioid_on	0	0	No	No	No	No	5	7
401	3x23	3x27	opioid_on	0	6.25	No	No	No	No	1	5
402	4x43	4x47	opioid_on	0	6.25	No	No	No	No	4	4
403	2x67	Lig	opioid_on	0	3.125	No	No	Yes	Yes	5	0
404	1x29	1x33	opioid_on	0	6.25	No	No	No	No	0	5
405	1x32	1x33	opioid_on	0	0	No	No	No	No	4	5
406	5x59	5x63	opioid_on	0	0	No	No	No	No	4	4
407	6x42	6x46	opioid_on	0	0	No	No	No	No	5	6
408	1x28	1x29	opioid_on	0	0	No	No	No	No	0	0
409	6x24	6x25	opioid_on	0	6.25	No	No	No	No	3	3
410	1x43	1x44	opioid_on	0	6.25	No	Yes	No	No	7	5
411	Lig	NT	opioid_on	0	3.125	Yes	Yes	No	No	0	2
412	6x46	6x47	opioid_on	0	0	No	No	No	No	6	8
413	I2x51	I2x52	opioid_on	0	0	No	No	No	No	5	4

Orange: nodes, hubs and links specific of opioid_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of opioid_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	opioid_off Avg Int. Strength	opioid_on Avg Int. Strength	opioid_off Num Of Links	opioid_on Num Of Links	ConSurf
1	1x42	opioid_off	0	0	4	2	7
2	1x50	opioid_off	0	0	4	3	9
3	1x60	opioid_off	0	0	4	3	5
4	2x41	opioid_off	0	0	4	2	5
5	2x45	opioid_off	75	0	4	3	9
6	2x57	opioid_off	25	0	4	2	7
7	3x37	opioid_off	25	18.75	4	2	6
8	3x50	opioid_off	50	0	6	2	9
9	5x40	opioid_off	0	25	4	3	4
10	6x44	opioid_off	100	0	5	3	9
11	7x34	opioid_off	16.6667	25	4	3	4
12	7x42	opioid_off	91.6667	31.25	4	3	6
13	7x49	opioid_off	0	68.75	4	3	9
14	8x54	opioid_off	0	0	4	1	6
15	1x39	Shared	25	9.375	4	4	6
16	2x42	Shared	91.6667	71.875	6	5	7
17	E1x50	Shared	66.6667	93.75	6	5	8
18	E1x52	Shared	66.6667	90.625	5	5	7
19	3x34	Shared	16.6667	50	4	5	5
20	3x51	Shared	25	62.5	5	4	7
21	4x50	Shared	66.6667	43.75	4	4	9
22	E2	Shared	100	100	12	13	3
23	5x47	Shared	0	37.5	4	4	8
24	5x58	Shared	50	81.25	4	6	8
25	I3	Shared	41.6667	50	6	4	4
26	6x48	Shared	75	68.75	6	6	8
27	7x45	Shared	33.3333	46.875	5	4	9
28	7x53	Shared	66.6667	50	4	5	9
29	8x50	Shared	66.6667	31.25	5	6	8
30	Lig	Shared	100	100	16	21	0
31	1x35	opioid_on	0	25	2	4	5
32	1x43	opioid_on	0	0	2	4	7
33	2x44	opioid_on	0	25	3	4	5
34	2x50	opioid_on	25	75	3	5	9
35	3x35	opioid_on	0	0	2	4	8
36	3x38	opioid_on	0	0	3	4	7
37	I2x56	opioid_on	0	0	2	4	4
38	5x44	opioid_on	0	37.5	3	4	5
39	6x30	opioid_on	0	0	1	4	6
40	6x52	opioid_on	25	75	3	5	8
41	E3	opioid_on	0	25	3	7	2
42	7x35	opioid_on	0	25	3	4	4

Orange: nodes, hubs and links specific of opioid_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of opioid_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	opioid_off Recurrence	opioid_on Recurrence	opioid_off Hub1?	opioid_on Hub1?	opioid_off Hub2?	opioid_on Hub2?	ConSurf1	ConSurf2
1	1x39	2x57	opioid_off	39.2048	0	Yes	Yes	Yes	No	6	7
2	1x42	2x57	opioid_off	11.9807	0	Yes	No	Yes	No	7	7
3	7x42	Lig	opioid_off	56.9085	0	Yes	No	Yes	Yes	6	0
4	6x48	Lig	opioid_off	79.9786	0	Yes	Yes	Yes	Yes	8	0
5	2x50	7x46	opioid_off	21.314	1.07629	No	Yes	No	No	9	8
6	2x54	7x46	opioid_off	18.711	0	No	No	No	No	6	8
7	1x50	2x50	opioid_off	18.711	5.33915	Yes	No	No	Yes	9	9
8	1x50	7x50	opioid_off	10.7952	3.2183	Yes	No	No	No	9	9
9	5x43	Lig	opioid_off	78.7663	8.02063	No	No	Yes	Yes	5	0
10	3x37	5x43	opioid_off	78.481	6.99193	Yes	No	No	No	6	5
11	3x37	3x41	opioid_off	77.4113	0	Yes	No	No	No	6	6
12	3x41	4x49	opioid_off	77.447	2.15523	No	No	No	No	6	7
13	2x45	4x49	opioid_off	75.7889	0	Yes	No	No	No	9	7
14	8x50	8x54	opioid_off	37.0209	1.03398	Yes	Yes	Yes	No	8	6
15	1x52	8x54	opioid_off	30.7185	0	No	No	Yes	No	6	6
16	1x52	8x57	opioid_off	28.4988	0	No	No	No	No	6	4
17	1x55	8x57	opioid_off	21.0822	0	No	No	No	No	4	4
18	1x55	1x59	opioid_off	18.7912	1.23232	No	No	No	No	4	5
19	1x59	1x60	opioid_off	16.4468	2.46199	No	No	Yes	No	5	5
20	6x44	6x48	opioid_off	59.458	0.682269	Yes	No	Yes	Yes	9	8
21	3x43	6x44	opioid_off	62.9881	0	No	No	Yes	No	8	9
22	3x43	6x41	opioid_off	61.5885	0	No	No	No	No	8	8
23	5x54	6x41	opioid_off	59.8592	0	No	No	No	No	8	8
24	3x47	5x54	opioid_off	58.629	0	No	No	No	No	9	8
25	3x47	5x58	opioid_off	58.2368	1.19265	No	No	Yes	Yes	9	8
26	5x58	6x37	opioid_off	50.517	0.978448	Yes	Yes	No	No	8	8
27	3x50	6x37	opioid_off	47.397	0	Yes	No	No	No	9	8
28	2x41	4x46	opioid_off	24.7014	4.29195	Yes	No	No	No	5	7
29	2x46	7x53	opioid_off	34.8993	0	No	No	Yes	Yes	9	9
30	E1x49	E2	opioid_off	40.2924	1.02076	No	No	Yes	Yes	4	3
31	2x66	E1x49	opioid_off	38.6076	0	No	No	No	No	4	4
32	2x66	E1x51	opioid_off	36.4503	2.30596	No	No	No	No	4	1
33	E1x51	E1x52	opioid_off	34.2753	4.60928	No	No	Yes	Yes	1	7
34	3x28	E1x50	opioid_off	11.535	0	No	No	Yes	Yes	6	8
35	7x34	7x38	opioid_off	35.1221	0.169245	Yes	No	No	No	4	5
36	3x40	6x44	opioid_off	20.6721	0	No	No	Yes	No	7	9
37	3x40	5x50	opioid_off	18.1494	4.22848	No	No	No	No	7	9
38	3x50	6x34	opioid_off	35.6035	0	Yes	No	No	No	9	6
39	3x51	5x61	opioid_off	30.6917	0	Yes	Yes	No	No	7	8
40	3x55	3x56	opioid_off	10.5099	0	No	No	No	No	7	6
41	2x41	4x39	opioid_off	22.0449	0	Yes	No	No	No	5	2
42	4x38	4x39	opioid_off	19.2369	3.22623	No	No	No	No	7	2
43	5x35	E2	opioid_off	12.0253	5.97382	No	No	Yes	Yes	7	3
44	5x47	6x52	opioid_off	37.11	4.26815	Yes	Yes	No	Yes	8	8
45	5x44	5x47	opioid_off	15.7693	0.145445	No	Yes	Yes	Yes	5	8
46	5x49	5x50	opioid_off	15.6088	1.06307	No	No	No	No	5	9
47	5x46	5x49	opioid_off	13.0505	0	No	No	No	No	4	5
48	5x47	6x49	opioid_off	12.6493	4.66217	Yes	Yes	No	No	8	5
49	6x31	6x34	opioid_off	33.0451	0	No	No	No	No	5	6
50	6x31	I3	opioid_off	30.4332	0	No	No	Yes	Yes	5	4
51	8x47	8x50	opioid_off	29.5596	3.68637	No	No	Yes	Yes	8	8
52	8x47	8x49	opioid_off	16.117	2.46199	No	No	No	No	8	6
53	8x49	8x52	opioid_off	13.7547	1.23232	No	No	No	No	6	5
54	8x48	8x52	opioid_off	11.3746	0	No	No	No	No	4	5
55	6x36	8x47	opioid_off	11.7846	0	No	No	No	No	8	8
56	6x54	7x34	opioid_off	11.5083	2.20547	No	No	Yes	No	5	4
57	1x36	2x61	opioid_off	28.7039	4.71506	No	No	No	No	5	6
58	1x39	2x61	opioid_off	30.8968	5.88126	Yes	Yes	No	No	6	6
59	1x36	2x65	opioid_off	21.9736	1.18472	No	No	No	No	5	4
60	6x58	7x34	opioid_off	15.7604	0	No	No	Yes	No	5	4
61	6x58	E3	opioid_off	13.8795	0.134867	No	No	No	Yes	5	2
62	5x67	I3	opioid_off	23.2929	0	No	No	Yes	Yes	4	4
63	5x67	6x25	opioid_off	21.0198	0	No	No	No	No	4	3
64	5x66	6x25	opioid_off	18.7377	0	No	No	No	No	4	3
65	4x38	4x41	opioid_off	13.5675	7.45736	No	No	No	No	7	5
66	5x66	6x27	opioid_off	10.6347	0	No	No	No	No	4	3
67	1x32	2x65	opioid_off	12.7385	0	No	No	No	No	4	4
68	6x44	7x45	opioid_off	22.348	3.23417	Yes	No	Yes	Yes	9	9
69	3x46	6x37	opioid_off	40.123	0	No	No	No	No	8	8
70	2x57	7x42	Shared	55.6071	16.0836	Yes	No	Yes	No	7	6
71	6x48	7x45	Shared	31.3692	97.895	Yes	Yes	Yes	Yes	8	9
72	7x45	7x49	Shared	49.9376	100	Yes	Yes	Yes	No	9	9
73	2x50	7x49	Shared	41.4958	39.0718	No	Yes	Yes	No	9	9
74	7x49	7x53	Shared	36.6197	64.3105	Yes	No	Yes	Yes	9	9
75	2x45	4x50	Shared	100	48.3961	Yes	No	Yes	Yes	9	9
76	2x48	4x50	Shared	79.8895	30.5487	No	No	Yes	Yes	6	9
77	1x54	2x48	Shared	78.0977	29.4513	No	No	No	No	7	6
78	1x54	2x44	Shared	76.2881	28.3485	No	No	No	Yes	7	5
79	1x57	2x44	Shared	72.6154	25.199	No	No	No	Yes	7	5
80	1x57	8x50	Shared	70.7524	20.6638	No	No	Yes	Yes	7	8
81	2x45	4x46	Shared	67.57	11.1067	Yes	No	No	No	9	7
82	2x42	4x46	Shared	50.9538	14.9808	Yes	Yes	No	No	7	7
83	2x42	3x49	Shared	13.9508	17.2841	Yes	Yes	No	No	7	8
84	2x42	3x46	Shared	41.5404	33.2355	Yes	Yes	No	No	7	8
85	E2	Lig	Shared	70.1105	17.1704	Yes	Yes	Yes	Yes	3	0
86	E1x50	E1x52	Shared	23.1236	16.0465	Yes	Yes	Yes	Yes	8	7
87	7x38	Lig	Shared	36.9139	25.1144	No	No	Yes	Yes	5	0
88	3x34	4x50	Shared	19.2459	15.5362	Yes	Yes	Yes	Yes	5	9
89	6x52	Lig	Shared	29.9073	51.6594	No	Yes	Yes	Yes	8	0
90	5x58	5x61	Shared	37.5557	42.9777	Yes	Yes	No	No	8	8
91	3x51	3x55	Shared	13.0505	12.8838	Yes	Yes	No	No	7	7
92	2x46	3x42	Shared	34.5249	39.5346	No	No	No	No	9	7
93	2x45	3x42	Shared	34.204	38.8602	Yes	No	No	No	9	7
94	3x36	6x48	Shared	10.6258	47.3198	No	No	Yes	Yes	7	8
95	1x39	7x35	opioid_on	0	15.6869	Yes	Yes	No	Yes	6	4
96	1x39	7x38	opioid_on	0	24.2893	Yes	Yes	No	No	6	5
97	2x60	Lig	opioid_on	1.75611	11.0406	No	No	Yes	Yes	7	0
98	1x43	2x57	opioid_on	4.84044	13.8014	No	Yes	Yes	No	7	7
99	3x32	Lig	opioid_on	1.95222	11.3103	No	No	Yes	Yes	6	0
100	3x36	Lig	opioid_on	1.32822	47.0977	No	No	Yes	Yes	7	0
101	6x48	6x52	opioid_on	0	52.9049	Yes	Yes	No	Yes	8	8
102	2x46	2x50	opioid_on	0	32.8309	No	No	No	Yes	9	9
103	3x46	7x53	opioid_on	0	35.076	No	No	Yes	Yes	8	9
104	E2x50	Lig	opioid_on	0	12.3575	No	No	Yes	Yes	9	0
105	E1x50	E2x50	opioid_on	2.42467	10.2816	Yes	Yes	No	No	8	9
106	2x63	Lig	opioid_on	0	11.2283	No	No	Yes	Yes	5	0
107	2x63	E1x50	opioid_on	2.43359	10.2843	No	No	Yes	Yes	5	8
108	3x50	7x53	opioid_on	0	49.208	Yes	No	Yes	Yes	9	9
109	3x50	5x58	opioid_on	0	48.4358	Yes	No	Yes	Yes	9	8
110	3x54	5x61	opioid_on	4.86718	41.9833	No	No	No	No	8	8
111	3x54	5x65	opioid_on	2.63862	40.9758	No	No	No	No	8	8
112	5x65	I3	opioid_on	0	32.1433	No	No	Yes	Yes	8	4
113	5x68	I3	opioid_on	2.78124	17.382	No	No	Yes	Yes	6	4
114	5x64	5x68	opioid_on	0	16.2687	No	No	No	No	5	6
115	3x55	5x64	opioid_on	0.035657	14.005	No	No	No	No	7	5
116	3x49	I2x56	opioid_on	0	13.2752	No	No	No	Yes	8	4
117	6x40	7x53	opioid_on	0	12.6802	No	No	Yes	Yes	8	9
118	6x40	7x52	opioid_on	0	11.7334	No	No	No	No	8	8

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
1x39	2x57	opioid_off	6.18833	0	0	0	2	2
2x57	7x42	Shared	9.66833	10.6012	0	0	2	1
2x60	7x42	Shared	9.01833	7.60938	1	1	1	1
2x60	Lig	Shared	7.12167	10.4116	1	1	1	0
2x63	E1x50	Shared	6.76333	5.91187	0	1	1	2
E1x49	E2	Shared	7.37167	4.99937	1	0	2	1
3x25	E1x50	Shared	4.35167	5.50938	2	1	2	2
E1x50	E2x50	Shared	11.5375	13.6306	2	1	2	1
3x22	E2	Shared	11.5192	8.63375	1	1	2	1
3x25	E2x50	Shared	7.28	7.28	2	1	2	1
3x32	Lig	Shared	21.9942	6.38969	1	1	1	0
3x33	4x60	Shared	7.37583	5.16062	1	1	1	2
3x33	Lig	Shared	9.58583	9.49719	1	1	1	0
3x36	6x48	Shared	8.82083	5.6725	1	1	1	1
3x36	6x52	opioid_off	4.62417	0	1	1	1	1
3x36	Lig	Shared	10.8825	8.88063	1	1	1	0
3x37	5x43	Shared	3.9025	3.42687	0	0	2	1
3x37	5x461	opioid_off	7.05583	0	0	0	2	2
3x40	6x44	opioid_off	5.88167	0	0	0	2	2
E2	E2	Shared	48.955	34.2606	1	1	1	1
E2	E2x51	Shared	7.47917	4.94406	1	1	1	2
5x32	E2	Shared	4.91333	3.44531	1	0	2	1
5x35	E2	Shared	9.4225	6.26219	1	1	2	1
5x36	E2	Shared	6.735	7.59375	1	1	2	1
5x39	E2	Shared	5.3	3.60781	0	0	2	1
5x32	5x36	opioid_off	3.63	0	1	0	2	2
5x36	5x40	Shared	7.9175	5.78969	1	1	2	1
5x40	6x55	opioid_off	3.71583	0	1	1	1	1
5x40	Lig	Shared	4.21667	3.83156	1	1	1	0
5x43	Lig	Shared	5.08417	4.54781	1	1	1	0
5x47	6x52	Shared	16.39	5.60094	0	1	2	1
6x44	6x48	Shared	18.8733	8.04781	1	1	2	1
6x44	7x45	Shared	6.54417	3.09469	1	1	2	2
6x48	6x51	opioid_off	3.60167	0	1	1	1	1
6x48	7x41	Shared	5.62833	0.659687	1	1	1	2
6x48	7x45	Shared	5.74417	9.25187	1	1	1	2
6x48	Lig	opioid_off	4.57083	0	1	1	1	0
6x51	Lig	Shared	4.125	3.34437	1	1	1	0
6x52	Lig	Shared	5.47833	3.86938	1	1	1	0
6x54	7x34	Shared	6.09	8.99094	0	0	2	1
6x54	7x37	opioid_off	3.68083	0	0	0	2	2
6x55	Lig	Shared	12.4858	7.37594	1	0	1	0
7x34	7x35	opioid_off	3.70333	0	0	1	1	2
7x34	7x38	Shared	5.9725	5.34969	0	1	1	1
7x38	Lig	Shared	4.39417	5.61906	1	1	1	0
7x42	Lig	opioid_off	8.33417	0	1	0	1	0
3x32	7x42	Shared	5.175	6.75625	1	1	1	1
6x58	E3	Shared	4.81417	3.75375	0	1	1	1
E2	Lig	Shared	4.88	13.1406	1	1	1	0
3x29	Lig	Shared	3.18583	5.91375	0	0	1	0
6x58	7x34	opioid_off	2.99917	0	0	1	1	1
4x63	E2	Shared	2.79417	3.13094	0	0	2	1
3x33	E2x52	Shared	2.78167	2.79063	1	1	1	2
5x44	5x47	Shared	2.41167	6.0625	0	1	2	2
7x30	E3	Shared	2.36333	3.76875	0	1	2	1
1x31	NT	opioid_off	2.28167	0	0	0	2	1
6x57	6x61	opioid_off	2.215	0	0	0	2	2
5x40	6x59	Shared	2.14917	4.29562	1	1	1	2
2x67	E2	opioid_off	1.1075	0	1	0	1	1
7x28	NT	opioid_off	0.916667	0	0	0	2	1
6x57	E3	opioid_off	0.829167	0	0	0	2	1
1x28	2x67	opioid_off	0.36	0	0	0	2	1
1x39	7x35	opioid_on	0	9.71594	0	0	2	2
1x39	7x38	opioid_on	0	4.515	0	0	2	1
2x56	2x60	opioid_on	0	3.18906	0	0	2	1
2x56	3x32	opioid_on	0	5.69125	0	0	2	1
3x40	6x48	opioid_on	0	3.26562	0	0	2	1
E2x50	Lig	opioid_on	0	4.61688	2	1	1	0
5x31	E2	opioid_on	0	3.85063	0	0	2	1
5x44	6x52	opioid_on	0	6.63781	0	1	2	1
6x48	6x52	opioid_on	0	4.34062	1	1	1	1
6x54	6x58	opioid_on	0	4.41781	0	0	2	1
6x58	Lig	opioid_on	0	4.96844	0	1	1	0
7x34	Lig	opioid_on	0	6.06063	0	1	1	0
5x461	6x52	opioid_on	0	3.44156	0	0	2	1
E2	E3	opioid_on	0	3.5675	1	1	1	1
E3	E3	opioid_on	0	5.62687	0	1	1	1
2x63	Lig	opioid_on	0	6.99063	0	1	1	0
E3	Lig	opioid_on	0	5.54125	0	1	1	0
6x51	7x37	opioid_on	0	2.60687	1	1	1	2
6x61	E3	opioid_on	0	1.84375	0	0	2	1
2x67	Lig	opioid_on	0	0.617813	1	0	1	0
Lig	NT	opioid_on	0	0.11125	1	1	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	opioid_off	kop_off mop_off nop_off dop_off
	opioid_on	kop_on mop_on nop_on dop_on

Network Difference
Value	opioid_off	opioid_on
I_min	3.59583	2.96625
Number of Linked Nodes	274	269
Number of Specific Nodes	5 (1.82%)	0 (0.00%)
Number of Shared Nodes	269 (98.18%)	269 (100.00%)
Number of Links	294	290
Number of Specific Links	123 (41.84%)	119 (41.03%)
Number of Shared Links	171 (58.16%)	171 (58.97%)
Number of Hubs	30	28
Number of Specific Hubs	14 (46.67%)	12 (42.86%)
Number of Shared Hubs	16 (53.33%)	16 (57.14%)
Average % Shared Neighbours (Jaccard)	46.13
Average % Shared Neighbours (Otsuka)	54.70
Average % Shared Neighbours (Overlap Coefficient)	63.48
Average % Shared Cliques (k3-6)	77.17
Graphlets Similarity	0.504975

Paths Difference
Value	opioid_off	opioid_on
Number Of Nodes in MetaPath	92	48
Specific Nodes in MetaPath	57 (61.96%)	13 (27.08%)
Shared Nodes in MetaPath	269 (98.18%)	269 (98.18%)
Number Of Links MetaPath	94	49
Specific Links in MetaPath	69 (73.40%)	24 (48.98%)
Shared Links in MetaPath	171 (58.16%)	171 (58.16%)
Number of Shortest Paths	38118	61553
Length Of Smallest Path	3	3
Average Path Length	13.0331	13.8803
Length of Longest Path	30	28
Minimum Path Strength	0.4225	0.253438
Average Path Strength	5.81897	5.41588
Maximum Path Strength	15.1461	16.0392
Minimum Path Correlation	0.704167	0.700312
Average Path Correlation	0.919541	0.914169
Maximum Path Correlation	0.989167	0.989375
Minimum % Of Corr. Nodes	3.84615	4
Average % Of Corr. Nodes	48.3493	43.2466
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	39.1362	40.9587
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

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