psnGPCR

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Orange: nodes, hubs and links specific of opioid_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of opioid_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	opioid_off Int. Strength	opioid_on Int. Strength	opioid_off Hub1?	opioid_on Hub1?	opioid_off Hub2?	opioid_on Hub2?	ConSurf1	ConSurf2
1	6x48	Lig	opioid_off	100	0	Yes	Yes	Yes	Yes	8	0
2	1x35	1x39	opioid_off	100	0	No	Yes	Yes	No	4	7
3	1x39	2x57	opioid_off	100	0	Yes	No	Yes	No	7	7
4	1x49	7x50	opioid_off	100	0	No	No	No	No	7	9
5	1x50	2x47	opioid_off	100	0	Yes	No	No	No	9	9
6	1x53	7x53	opioid_off	100	0	No	No	Yes	Yes	9	9
7	1x56	8x53	opioid_off	100	0	No	No	No	No	7	5
8	1x57	8x50	opioid_off	100	0	No	No	Yes	Yes	7	9
9	2x40	I1x50	opioid_off	100	0	No	No	No	No	8	7
10	8x50	I1x50	opioid_off	100	0	Yes	Yes	No	No	9	7
11	2x38	3x49	opioid_off	100	0	No	No	No	No	6	8
12	2x39	3x50	opioid_off	100	0	No	No	Yes	No	8	9
13	2x39	6x33	opioid_off	100	0	No	No	No	No	8	7
14	2x40	8x50	opioid_off	100	0	No	No	Yes	Yes	8	9
15	2x41	4x42	opioid_off	100	0	Yes	No	No	No	6	7
16	2x43	7x53	opioid_off	100	0	No	No	Yes	Yes	8	9
17	2x45	4x49	opioid_off	100	0	Yes	No	No	No	9	7
18	2x52	3x31	opioid_off	100	0	No	No	No	No	7	5
19	2x56	3x28	opioid_off	100	0	No	No	No	No	6	5
20	2x56	3x31	opioid_off	100	0	No	No	No	No	6	5
21	2x59	3x24	opioid_off	100	0	No	No	No	No	6	6
22	2x66	E1x49	opioid_off	100	0	No	No	No	No	3	5
23	3x28	E1x50	opioid_off	100	0	No	No	Yes	Yes	5	8
24	3x30	3x34	opioid_off	100	0	No	No	Yes	Yes	6	4
25	3x34	4x57	opioid_off	100	0	Yes	Yes	No	No	4	7
26	3x35	3x39	opioid_off	100	0	No	Yes	No	No	8	9
27	3x36	6x52	opioid_off	100	0	No	No	No	Yes	7	8
28	3x37	3x41	opioid_off	100	0	Yes	No	No	No	7	6
29	3x37	5x461	opioid_off	100	0	Yes	No	No	No	7	6
30	3x39	6x44	opioid_off	100	0	No	No	Yes	No	9	9
31	3x40	6x44	opioid_off	100	0	No	No	Yes	No	8	9
32	3x42	4x49	opioid_off	100	0	No	No	No	No	7	7
33	3x43	6x41	opioid_off	100	0	No	No	No	No	8	8
34	3x43	6x44	opioid_off	100	0	No	No	Yes	No	8	9
35	3x44	5x54	opioid_off	100	0	No	No	No	No	7	8
36	3x46	6x37	opioid_off	100	0	No	No	No	No	8	7
37	3x50	3x53	opioid_off	100	0	Yes	No	No	No	9	8
38	3x50	6x33	opioid_off	100	0	Yes	No	No	No	9	7
39	3x50	6x34	opioid_off	100	0	Yes	No	No	No	9	6
40	3x50	6x37	opioid_off	100	0	Yes	No	No	No	9	7
41	3x51	5x61	opioid_off	100	0	Yes	Yes	No	No	8	8
42	3x51	5x64	opioid_off	100	0	Yes	Yes	No	No	8	5
43	5x54	6x41	opioid_off	100	0	No	No	No	No	8	8
44	5x58	6x38	opioid_off	100	0	Yes	Yes	No	No	9	4
45	6x28	6x32	opioid_off	100	0	No	No	Yes	No	4	7
46	6x32	6x35	opioid_off	100	0	Yes	No	No	No	7	6
47	6x36	8x47	opioid_off	100	0	No	No	No	No	8	8
48	6x39	7x56	opioid_off	100	0	No	No	No	No	6	6
49	6x44	7x45	opioid_off	100	0	Yes	No	Yes	No	9	9
50	6x48	6x51	opioid_off	100	0	Yes	Yes	No	No	8	6
51	6x54	7x37	opioid_off	100	0	No	No	No	No	4	6
52	7x34	7x35	opioid_off	100	0	No	No	No	Yes	5	4
53	1x39	2x61	opioid_off	100	0	Yes	No	No	No	7	6
54	2x42	4x45	opioid_off	100	0	Yes	Yes	No	No	7	5
55	5x32	5x36	opioid_off	100	0	No	No	No	No	3	4
56	I3	I3	opioid_off	100	0	Yes	Yes	Yes	Yes	4	4
57	7x31	E3	opioid_off	100	0	No	No	Yes	Yes	4	2
58	8x48	8x52	opioid_off	100	0	No	No	No	No	4	4
59	5x67	6x25	opioid_off	25	0	No	No	No	No	4	2
60	1x52	8x54	opioid_off	50	0	No	No	Yes	No	6	6
61	5x42	5x46	opioid_off	58.3333	0	No	No	No	No	3	4
62	6x24	I3	opioid_off	50	0	No	No	Yes	Yes	0	4
63	1x46	2x54	opioid_off	25	0	No	No	No	No	8	6
64	1x42	2x57	opioid_off	33.3333	0	Yes	No	Yes	No	7	7
65	1x60	8x53	opioid_off	58.3333	0	Yes	No	No	No	5	5
66	6x40	7x49	opioid_off	50	0	No	No	Yes	Yes	8	9
67	1x55	8x57	opioid_off	50	0	No	No	No	No	4	5
68	6x47	7x40	opioid_off	41.6667	0	No	No	No	No	8	7
69	I1x48	I1x51	opioid_off	33.3333	0	No	No	No	No	6	6
70	2x54	7x46	opioid_off	25	0	No	No	No	No	6	9
71	1x52	8x57	opioid_off	50	0	No	No	No	No	6	5
72	2x49	3x38	opioid_off	0	0	No	No	No	No	8	7
73	6x32	6x33	opioid_off	33.3333	0	Yes	No	No	No	7	7
74	6x27	I3	opioid_off	50	0	Yes	No	Yes	Yes	3	4
75	3x48	5x57	opioid_off	8.33333	0	No	No	No	No	6	7
76	6x26	6x27	opioid_off	25	0	No	No	Yes	No	4	3
77	5x46	5x49	opioid_off	8.33333	0	No	No	No	No	4	5
78	1x60	8x56	opioid_off	50	0	Yes	No	No	No	5	4
79	1x31	NT	opioid_off	25	0	No	No	No	No	3	0
80	6x31	6x34	opioid_off	25	0	No	No	No	No	5	6
81	6x57	6x61	opioid_off	25	0	No	No	No	No	5	3
82	5x31	5x34	opioid_off	33.3333	0	No	No	No	No	1	3
83	1x60	I1x48	opioid_off	33.3333	0	Yes	No	No	No	5	6
84	6x43	7x45	opioid_off	8.33333	0	No	No	Yes	No	6	9
85	6x45	6x49	opioid_off	8.33333	0	No	No	No	No	5	5
86	5x51	5x55	opioid_off	0	0	No	No	No	No	6	4
87	3x50	6x30	opioid_off	16.6667	0	Yes	No	No	Yes	9	6
88	1x45	1x46	opioid_off	8.33333	0	No	No	No	No	5	8
89	2x41	4x39	opioid_off	0	0	Yes	No	No	No	6	1
90	1x31	1x32	opioid_off	25	0	No	No	No	No	3	4
91	5x37	5x41	opioid_off	25	0	No	No	No	No	3	4
92	5x31	5x33	opioid_off	33.3333	0	No	No	No	No	1	2
93	I2x55	I2x57	opioid_off	25	0	No	No	No	No	4	6
94	1x38	1x42	opioid_off	8.33333	0	No	No	Yes	No	5	7
95	8x54	8x55	opioid_off	25	0	Yes	No	No	No	6	5
96	1x47	2x55	opioid_off	16.6667	0	No	No	No	No	6	5
97	7x55	7x56	opioid_off	8.33333	0	No	No	No	No	6	6
98	6x25	6x26	opioid_off	25	0	No	No	No	No	2	4
99	1x32	2x65	opioid_off	0	0	No	No	No	No	4	5
100	7x54	8x54	opioid_off	8.33333	0	No	No	Yes	No	7	6
101	8x58	8x59	opioid_off	8.33333	0	No	No	No	No	5	2
102	2x67	E2	opioid_off	25	0	No	No	Yes	Yes	4	4
103	3x23	3x24	opioid_off	0	0	No	No	No	No	2	6
104	5x48	5x52	opioid_off	0	0	No	No	No	No	5	3
105	6x41	6x42	opioid_off	0	0	No	No	No	No	8	5
106	7x28	NT	opioid_off	25	0	No	No	No	No	4	0
107	5x66	6x27	opioid_off	0	0	No	No	Yes	No	4	3
108	1x29	1x32	opioid_off	8.33333	0	No	No	No	No	2	4
109	1x33	2x65	opioid_off	0	0	No	No	No	No	4	5
110	6x57	E3	opioid_off	16.6667	0	No	No	Yes	Yes	5	2
111	7x32	7x33	opioid_off	0	0	No	No	No	No	1	5
112	1x44	1x48	opioid_off	0	0	No	No	No	No	5	4
113	1x25	1x29	opioid_off	0	0	No	No	No	No	0	2
114	8x57	8x58	opioid_off	0	0	No	No	No	No	5	5
115	4x61	4x62	opioid_off	8.33333	0	No	No	No	No	4	5
116	6x45	6x46	opioid_off	0	0	No	No	No	No	5	6
117	5x59	5x62	opioid_off	0	0	No	No	No	No	2	5
118	1x27	1x28	opioid_off	0	0	No	No	No	No	0	0
119	8x59	CT	opioid_off	0	0	No	No	No	No	2	0
120	1x28	2x67	opioid_off	0	0	No	No	No	No	0	4
121	4x41	4x44	opioid_off	0	0	No	No	No	No	4	3
122	3x32	Lig	Shared	100	100	No	No	Yes	Yes	6	0
123	3x33	Lig	Shared	100	100	No	No	Yes	Yes	4	0
124	3x36	Lig	Shared	100	100	No	No	Yes	Yes	7	0
125	5x40	Lig	Shared	100	100	Yes	Yes	Yes	Yes	4	0
126	5x43	Lig	Shared	100	100	No	No	Yes	Yes	5	0
127	6x51	Lig	Shared	100	50	No	No	Yes	Yes	6	0
128	6x52	Lig	Shared	100	100	No	Yes	Yes	Yes	8	0
129	6x55	Lig	Shared	100	100	No	No	Yes	Yes	5	0
130	7x38	Lig	Shared	100	100	No	No	Yes	Yes	5	0
131	7x42	Lig	Shared	100	100	Yes	Yes	Yes	Yes	7	0
132	1x36	2x65	Shared	100	100	No	Yes	No	No	5	5
133	1x42	7x47	Shared	100	53.8462	Yes	No	No	Yes	7	7
134	1x43	2x58	Shared	100	100	No	Yes	No	No	6	8
135	1x47	2x54	Shared	100	100	No	No	No	No	6	6
136	1x50	2x50	Shared	100	100	Yes	No	No	Yes	9	9
137	1x50	7x50	Shared	100	100	Yes	No	No	No	9	9
138	1x54	2x44	Shared	100	100	No	No	No	Yes	7	6
139	1x54	2x48	Shared	100	100	No	No	No	No	7	6
140	1x55	1x59	Shared	100	100	No	No	No	No	4	4
141	1x58	2x44	Shared	100	55.7692	No	No	No	Yes	3	6
142	1x59	1x60	Shared	100	100	No	No	Yes	No	4	5
143	2x37	2x40	Shared	100	100	No	No	No	No	8	8
144	2x41	4x46	Shared	100	64.1026	Yes	No	No	No	6	7
145	2x42	3x45	Shared	100	100	Yes	Yes	No	No	7	7
146	2x42	3x46	Shared	100	100	Yes	Yes	No	No	7	8
147	2x42	3x49	Shared	100	100	Yes	Yes	No	No	7	8
148	2x42	4x42	Shared	100	100	Yes	Yes	No	No	7	7
149	2x42	4x46	Shared	100	100	Yes	Yes	No	No	7	7
150	2x45	3x42	Shared	100	100	Yes	No	No	No	9	7
151	2x45	4x46	Shared	100	100	Yes	No	No	No	9	7
152	2x45	4x50	Shared	100	100	Yes	No	Yes	Yes	9	9
153	2x46	3x42	Shared	100	100	No	Yes	No	No	9	7
154	2x46	7x53	Shared	100	100	No	Yes	Yes	Yes	9	9
155	2x48	4x50	Shared	100	100	No	No	Yes	Yes	6	9
156	2x50	7x46	Shared	100	100	No	Yes	No	No	9	9
157	2x50	7x49	Shared	100	100	No	Yes	Yes	Yes	9	9
158	2x53	3x35	Shared	100	32.6923	No	No	No	Yes	7	8
159	2x57	7x42	Shared	100	100	Yes	No	Yes	Yes	7	7
160	2x59	E1x52	Shared	100	100	No	No	Yes	Yes	6	7
161	2x60	7x42	Shared	100	100	No	No	Yes	Yes	6	7
162	2x62	E1x52	Shared	100	100	No	No	Yes	Yes	5	7
163	2x63	E1x50	Shared	100	100	No	No	Yes	Yes	6	8
164	2x64	7x35	Shared	100	100	No	Yes	No	Yes	5	4
165	2x66	E1x51	Shared	100	69.8718	No	No	No	No	3	4
166	E1x49	E2	Shared	100	100	No	No	Yes	Yes	5	4
167	E1x50	E1x52	Shared	100	100	Yes	Yes	Yes	Yes	8	7
168	3x25	E1x50	Shared	100	100	No	No	Yes	Yes	9	8
169	E1x50	E2x50	Shared	100	100	Yes	Yes	No	No	8	9
170	E1x51	E1x52	Shared	100	100	No	No	Yes	Yes	4	7
171	3x24	E1x52	Shared	100	100	No	No	Yes	Yes	6	7
172	3x22	E2	Shared	100	100	No	No	Yes	Yes	1	4
173	3x25	E2x50	Shared	100	100	No	No	No	No	9	9
174	3x30	4x61	Shared	100	100	No	No	No	No	6	4
175	3x32	7x42	Shared	100	100	No	No	Yes	Yes	6	7
176	3x33	4x60	Shared	100	100	No	No	No	No	4	5
177	3x34	4x50	Shared	100	100	Yes	Yes	Yes	Yes	4	9
178	3x34	4x54	Shared	100	100	Yes	Yes	No	No	4	3
179	3x36	6x48	Shared	100	100	No	No	Yes	Yes	7	8
180	3x37	4x56	Shared	100	100	Yes	No	No	No	7	4
181	3x37	5x43	Shared	100	100	Yes	No	No	No	7	5
182	3x38	4x50	Shared	100	100	No	No	Yes	Yes	7	9
183	3x40	5x50	Shared	100	100	No	No	No	No	8	9
184	3x41	4x49	Shared	100	100	No	No	No	No	6	7
185	3x41	4x52	Shared	100	10.2564	No	No	No	No	6	4
186	3x45	4x45	Shared	100	55.7692	No	No	No	No	7	5
187	3x47	5x54	Shared	100	100	No	No	No	No	9	8
188	3x47	5x58	Shared	100	100	No	No	Yes	Yes	9	9
189	3x49	I2x57	Shared	100	100	No	No	No	No	8	6
190	3x51	3x55	Shared	100	100	Yes	Yes	No	No	8	7
191	3x51	5x60	Shared	100	100	Yes	Yes	No	No	8	4
192	3x55	5x64	Shared	100	39.1026	No	No	No	No	7	5
193	4x38	4x39	Shared	100	30.7692	No	No	No	No	7	1
194	E2	E2	Shared	100	100	Yes	Yes	Yes	Yes	4	4
195	E2	E2x51	Shared	100	100	Yes	Yes	No	No	4	3
196	5x32	E2	Shared	100	100	No	No	Yes	Yes	3	4
197	5x35	E2	Shared	100	100	No	No	Yes	Yes	3	4
198	5x36	E2	Shared	100	100	No	No	Yes	Yes	4	4
199	5x39	E2	Shared	100	100	No	No	Yes	Yes	5	4
200	5x34	5x35	Shared	100	100	No	No	No	No	3	3
201	5x34	5x38	Shared	100	100	No	No	No	No	3	4
202	5x36	5x40	Shared	100	100	No	No	Yes	Yes	4	4
203	5x40	6x55	Shared	100	100	Yes	Yes	No	No	4	5
204	5x44	5x48	Shared	100	100	No	Yes	No	No	5	5
205	5x44	6x56	Shared	100	100	No	Yes	No	No	5	6
206	5x45	5x46	Shared	100	50	No	No	No	No	4	4
207	5x47	5x51	Shared	100	100	Yes	Yes	No	No	8	6
208	5x47	6x49	Shared	100	100	Yes	Yes	No	No	8	5
209	5x47	6x52	Shared	100	100	Yes	Yes	No	Yes	8	8
210	5x49	5x50	Shared	100	100	No	No	No	No	5	9
211	5x58	5x61	Shared	100	100	Yes	Yes	No	No	9	8
212	6x36	7x56	Shared	100	41.6667	No	No	No	No	8	6
213	6x44	6x48	Shared	100	100	Yes	No	Yes	Yes	9	8
214	6x47	7x45	Shared	100	100	No	No	Yes	No	8	9
215	6x48	7x45	Shared	100	100	Yes	Yes	Yes	No	8	9
216	6x50	7x37	Shared	100	33.3333	No	No	No	No	9	6
217	6x54	7x34	Shared	100	100	No	No	No	No	4	5
218	6x58	E3	Shared	100	100	No	No	Yes	Yes	4	2
219	7x34	7x38	Shared	100	100	No	No	No	No	5	5
220	7x45	7x49	Shared	100	100	Yes	No	Yes	Yes	9	9
221	7x49	7x53	Shared	100	100	Yes	Yes	Yes	Yes	9	9
222	8x47	8x49	Shared	100	100	No	No	No	No	8	6
223	8x47	8x50	Shared	100	100	No	No	Yes	Yes	8	9
224	1x36	2x61	Shared	100	100	No	Yes	No	No	5	6
225	2x60	Lig	Shared	100	100	No	No	Yes	Yes	6	0
226	3x54	5x61	Shared	100	100	No	No	No	No	8	8
227	5x58	6x37	Shared	100	100	Yes	Yes	No	No	9	7
228	6x48	7x41	Shared	100	7.69231	Yes	Yes	No	No	8	7
229	E2	Lig	Shared	100	100	Yes	Yes	Yes	Yes	4	0
230	6x32	8x48	Shared	100	100	Yes	No	No	No	7	4
231	7x31	7x35	Shared	100	26.9231	No	No	No	Yes	4	4
232	Lig	Lig	Shared	100	100	Yes	Yes	Yes	Yes	0	0
233	6x43	7x52	Shared	33.3333	50	No	No	No	No	6	8
234	3x51	5x57	Shared	66.6667	100	Yes	Yes	No	No	8	7
235	3x55	3x56	Shared	33.3333	100	No	No	No	Yes	7	6
236	3x56	I2x52	Shared	25	12.1795	No	Yes	No	No	6	4
237	1x57	2x44	Shared	41.6667	100	No	No	No	Yes	7	6
238	1x43	2x57	Shared	33.3333	100	No	Yes	Yes	No	6	7
239	7x27	7x29	Shared	50	25	No	No	No	No	1	2
240	3x29	Lig	Shared	33.3333	100	No	No	Yes	Yes	5	0
241	5x68	I3	Shared	33.3333	100	No	No	Yes	Yes	6	4
242	3x38	4x53	Shared	50	100	No	No	No	No	7	8
243	4x54	4x58	Shared	25	21.7949	No	No	No	No	3	3
244	8x50	8x54	Shared	33.3333	25	Yes	Yes	Yes	No	9	6
245	4x38	4x41	Shared	50	100	No	No	No	No	7	4
246	1x42	7x43	Shared	8.33333	100	Yes	No	No	No	7	5
247	3x54	5x65	Shared	66.6667	100	No	No	No	No	8	8
248	4x63	E2	Shared	33.3333	100	No	No	Yes	Yes	4	4
249	3x33	E2x52	Shared	16.6667	34.6154	No	No	No	No	4	5
250	3x44	5x53	Shared	25	100	No	No	No	No	7	7
251	2x41	4x43	Shared	8.33333	39.1026	Yes	No	No	No	6	2
252	4x58	4x59	Shared	25	51.9231	No	No	No	No	3	7
253	3x21	E1x50	Shared	0	25	No	No	Yes	Yes	7	8
254	4x38	4x40	Shared	25	0	No	No	No	No	7	3
255	3x22	3x26	Shared	41.6667	100	No	No	No	No	1	6
256	5x44	5x47	Shared	41.6667	100	No	Yes	Yes	Yes	5	8
257	3x52	I2x56	Shared	33.3333	100	No	No	No	Yes	5	4
258	7x27	7x30	Shared	50	25	No	No	No	No	1	4
259	7x30	E3	Shared	25	100	No	No	Yes	Yes	4	2
260	3x26	4x64	Shared	25	28.8462	No	No	No	No	6	4
261	1x35	7x36	Shared	25	25	No	Yes	No	No	4	5
262	5x60	5x63	Shared	33.3333	25	No	No	No	No	4	2
263	5x40	6x59	Shared	25	100	Yes	Yes	No	No	4	4
264	6x54	7x33	Shared	25	50	No	No	No	No	4	5
265	8x48	8x51	Shared	25	100	No	No	No	No	4	8
266	6x29	6x32	Shared	25	100	No	No	Yes	No	5	7
267	7x43	7x48	Shared	25	35.2564	No	No	No	No	5	7
268	1x50	2x51	Shared	0	100	Yes	No	No	No	9	7
269	4x41	I2x56	Shared	33.3333	28.2051	No	No	No	Yes	4	4
270	1x48	1x49	Shared	25	0	No	No	No	No	4	7
271	6x56	6x60	Shared	25	0	No	No	No	No	6	5
272	3x27	3x31	Shared	0	26.9231	No	No	No	No	5	5
273	4x47	4x51	Shared	33.3333	8.33333	No	No	No	No	4	4
274	5x41	5x45	Shared	8.33333	26.9231	No	No	No	No	4	4
275	5x56	5x60	Shared	0	16.6667	No	No	No	No	4	4
276	3x56	I2x50	Shared	0	0	No	Yes	No	No	6	7
277	6x27	6x30	Shared	25	25	Yes	No	No	Yes	3	6
278	7x51	7x55	Shared	0	100	No	No	No	No	6	6
279	6x49	6x53	Shared	0	18.5897	No	No	No	No	5	6
280	6x23	6x26	Shared	8.33333	100	No	No	No	No	0	4
281	1x39	7x39	Shared	0	50	Yes	No	No	No	7	4
282	I1x49	I1x51	Shared	8.33333	30.7692	No	No	No	No	5	6
283	1x36	1x40	Shared	0	1.92308	No	Yes	No	No	5	4
284	1x30	1x33	Shared	16.6667	25	No	No	No	No	2	4
285	1x37	1x40	Shared	25	25	No	No	No	No	5	4
286	1x30	1x34	Shared	0	0	No	No	No	No	2	4
287	I2x54	I2x55	Shared	8.33333	0	No	No	No	No	5	4
288	I2x53	I2x57	Shared	0	0	No	No	No	No	6	6
289	4x44	4x48	Shared	0	0	No	No	No	No	3	4
290	1x47	1x51	Shared	8.33333	33.3333	No	No	No	No	6	4
291	I2x50	I2x51	Shared	0	0	No	No	No	No	7	5
292	1x41	1x45	Shared	0	0	No	No	No	No	5	5
293	4x55	4x56	Shared	0	8.33333	No	No	No	No	4	4
294	5x55	5x59	Shared	0	0	No	No	No	No	4	2
295	7x34	Lig	opioid_on	0	100	No	No	Yes	Yes	5	0
296	2x63	Lig	opioid_on	0	100	No	No	Yes	Yes	6	0
297	3x28	Lig	opioid_on	0	100	No	No	Yes	Yes	5	0
298	E2x50	Lig	opioid_on	0	100	No	No	Yes	Yes	9	0
299	1x35	2x64	opioid_on	0	100	No	Yes	No	Yes	4	5
300	1x35	7x35	opioid_on	0	100	No	Yes	No	Yes	4	4
301	1x39	7x35	opioid_on	0	100	Yes	No	No	Yes	7	4
302	1x39	7x38	opioid_on	0	100	Yes	No	No	No	7	5
303	1x43	1x47	opioid_on	0	100	No	Yes	No	No	6	6
304	1x53	7x54	opioid_on	0	100	No	No	No	No	9	7
305	1x56	1x60	opioid_on	0	100	No	No	Yes	No	7	5
306	1x56	8x50	opioid_on	0	100	No	No	Yes	Yes	7	9
307	1x60	8x57	opioid_on	0	100	Yes	No	No	No	5	5
308	2x40	I1x48	opioid_on	0	100	No	No	No	No	8	6
309	2x44	I1x50	opioid_on	0	100	No	Yes	No	No	6	7
310	2x46	2x50	opioid_on	0	100	No	Yes	No	Yes	9	9
311	2x46	3x43	opioid_on	0	100	No	Yes	No	No	9	8
312	2x46	7x49	opioid_on	0	100	No	Yes	Yes	Yes	9	9
313	2x50	3x39	opioid_on	0	100	No	Yes	No	No	9	9
314	2x52	3x35	opioid_on	0	100	No	No	No	Yes	7	8
315	2x56	2x60	opioid_on	0	100	No	No	No	No	6	6
316	2x56	3x32	opioid_on	0	100	No	No	No	No	6	6
317	2x59	3x28	opioid_on	0	100	No	No	No	No	6	5
318	3x25	E2	opioid_on	0	100	No	No	Yes	Yes	9	4
319	3x34	3x38	opioid_on	0	100	Yes	Yes	No	No	4	7
320	3x34	4x53	opioid_on	0	100	Yes	Yes	No	No	4	8
321	3x40	6x48	opioid_on	0	100	No	No	Yes	Yes	8	8
322	3x43	7x53	opioid_on	0	100	No	No	Yes	Yes	8	9
323	3x44	5x50	opioid_on	0	100	No	No	No	No	7	9
324	3x45	4x49	opioid_on	0	100	No	No	No	No	7	7
325	3x46	7x53	opioid_on	0	100	No	No	Yes	Yes	8	9
326	3x50	5x58	opioid_on	0	100	Yes	No	Yes	Yes	9	9
327	3x50	7x53	opioid_on	0	100	Yes	No	Yes	Yes	9	9
328	3x51	3x56	opioid_on	0	100	Yes	Yes	No	Yes	8	6
329	3x53	I2x57	opioid_on	0	100	No	No	No	No	8	6
330	5x31	E2	opioid_on	0	100	No	No	Yes	Yes	1	4
331	5x33	5x34	opioid_on	0	100	No	No	No	No	2	3
332	5x44	6x52	opioid_on	0	100	No	Yes	No	Yes	5	8
333	5x45	5x48	opioid_on	0	100	No	No	No	No	4	5
334	5x461	6x52	opioid_on	0	100	No	No	No	Yes	6	8
335	5x51	6x44	opioid_on	0	100	No	No	Yes	No	6	9
336	5x62	6x34	opioid_on	0	100	No	No	No	No	5	6
337	5x65	I3	opioid_on	0	100	No	No	Yes	Yes	8	4
338	6x30	I3	opioid_on	0	100	No	Yes	Yes	Yes	6	4
339	6x25	6x28	opioid_on	0	100	No	No	No	No	2	4
340	6x40	7x53	opioid_on	0	100	No	No	Yes	Yes	8	9
341	6x48	6x52	opioid_on	0	100	Yes	Yes	No	Yes	8	8
342	6x49	6x50	opioid_on	0	100	No	No	No	No	5	9
343	E3	E3	opioid_on	0	100	Yes	Yes	Yes	Yes	2	2
344	6x54	6x58	opioid_on	0	100	No	No	No	No	4	4
345	6x31	6x35	opioid_on	0	100	No	No	No	No	5	6
346	6x58	Lig	opioid_on	0	100	No	No	Yes	Yes	4	0
347	E2	E3	opioid_on	0	100	Yes	Yes	Yes	Yes	4	2
348	E3	Lig	opioid_on	0	100	Yes	Yes	Yes	Yes	2	0
349	3x34	3x35	opioid_on	0	65.3846	Yes	Yes	No	Yes	4	8
350	1x46	7x47	opioid_on	0	66.6667	No	No	No	Yes	8	7
351	5x38	5x42	opioid_on	0	26.9231	No	No	No	No	4	3
352	1x53	2x47	opioid_on	0	36.5385	No	No	No	No	9	9
353	5x51	6x45	opioid_on	0	63.4615	No	No	No	No	6	5
354	3x31	3x35	opioid_on	0	75	No	No	No	Yes	5	8
355	2x49	3x39	opioid_on	0	58.3333	No	No	No	No	8	9
356	5x58	6x41	opioid_on	0	19.8718	Yes	Yes	No	No	9	8
357	1x36	2x64	opioid_on	0	50	No	Yes	No	Yes	5	5
358	6x30	6x34	opioid_on	0	58.3333	No	Yes	No	No	6	6
359	3x48	3x52	opioid_on	0	35.2564	No	No	No	No	6	5
360	1x38	7x39	opioid_on	0	50	No	No	No	No	5	4
361	1x31	7x32	opioid_on	0	37.1795	No	No	No	No	3	1
362	8x49	8x52	opioid_on	0	50	No	No	No	No	6	4
363	7x55	8x50	opioid_on	0	50	No	No	Yes	Yes	6	9
364	2x43	3x46	opioid_on	0	35.2564	No	No	No	No	8	8
365	2x39	2x43	opioid_on	0	43.5897	No	No	No	No	8	8
366	1x31	1x35	opioid_on	0	50	No	No	No	Yes	3	4
367	5x64	5x67	opioid_on	0	10.2564	No	No	No	No	5	4
368	6x26	I3	opioid_on	0	53.8462	No	No	Yes	Yes	4	4
369	1x53	1x57	opioid_on	0	51.9231	No	No	No	No	9	7
370	7x48	7x52	opioid_on	0	30.7692	No	No	No	No	7	8
371	7x54	8x50	opioid_on	0	34.6154	No	No	Yes	Yes	7	9
372	2x54	7x47	opioid_on	0	26.9231	No	No	No	Yes	6	7
373	8x53	I1x48	opioid_on	0	33.3333	No	No	No	No	5	6
374	6x61	E3	opioid_on	0	25	No	No	Yes	Yes	3	2
375	6x32	6x36	opioid_on	0	33.3333	Yes	No	No	No	7	8
376	5x64	5x68	opioid_on	0	34.6154	No	No	No	No	5	6
377	2x38	4x42	opioid_on	0	0	No	No	No	No	6	7
378	5x55	6x41	opioid_on	0	8.33333	No	No	No	No	4	8
379	7x27	7x28	opioid_on	0	26.9231	No	No	No	No	1	4
380	4x58	4x62	opioid_on	0	26.9231	No	No	No	No	3	5
381	8x50	I1x48	opioid_on	0	30.7692	Yes	Yes	No	No	9	6
382	5x65	6x33	opioid_on	0	8.33333	No	No	No	No	8	7
383	6x34	6x38	opioid_on	0	33.3333	No	No	No	No	6	4
384	3x49	I2x56	opioid_on	0	19.8718	No	No	No	Yes	8	4
385	7x36	7x40	opioid_on	0	32.6923	No	No	No	No	5	7
386	6x29	6x33	opioid_on	0	28.8462	No	No	No	No	5	7
387	4x39	I1x51	opioid_on	0	25	No	No	No	No	1	6
388	4x56	4x57	opioid_on	0	0	No	No	No	No	4	7
389	1x32	2x64	opioid_on	0	5.76923	No	No	No	Yes	4	5
390	6x23	6x24	opioid_on	0	25	No	No	No	No	0	0
391	5x37	6x59	opioid_on	0	25	No	No	No	No	3	4
392	I2x55	I2x56	opioid_on	0	25	No	No	No	Yes	4	4
393	6x53	6x57	opioid_on	0	1.92308	No	No	No	No	6	5
394	3x30	4x57	opioid_on	0	0	No	No	No	No	6	7
395	8x51	8x55	opioid_on	0	26.9231	No	No	No	No	8	5
396	2x52	2x55	opioid_on	0	8.33333	No	No	No	No	7	5
397	4x40	4x44	opioid_on	0	17.9487	No	No	No	No	3	3
398	1x52	7x55	opioid_on	0	21.7949	No	No	No	No	6	6
399	5x66	6x30	opioid_on	0	8.33333	No	No	No	Yes	4	6
400	5x52	5x56	opioid_on	0	25	No	No	No	No	3	4
401	8x56	8x57	opioid_on	0	1.92308	No	No	No	No	4	5
402	6x39	6x43	opioid_on	0	0	No	No	No	No	6	6
403	6x25	6x29	opioid_on	0	26.9231	No	No	No	No	2	5
404	1x45	7x47	opioid_on	0	19.8718	No	No	No	Yes	5	7
405	1x33	2x64	opioid_on	0	25	No	No	No	Yes	4	5
406	6x27	6x31	opioid_on	0	8.33333	Yes	No	No	No	3	5
407	1x49	7x51	opioid_on	0	25	No	No	No	No	7	6
408	1x43	1x44	opioid_on	0	25	No	Yes	No	No	6	5
409	2x67	Lig	opioid_on	0	1.92308	No	No	Yes	Yes	4	0
410	3x23	3x27	opioid_on	0	0	No	No	No	No	2	5
411	6x42	6x46	opioid_on	0	0	No	No	No	No	5	6
412	1x28	1x29	opioid_on	0	0	No	No	No	No	0	2
413	1x29	1x33	opioid_on	0	3.84615	No	No	No	No	2	4
414	4x51	4x54	opioid_on	0	0	No	No	No	No	4	3
415	8x57	8x59	opioid_on	0	1.92308	No	No	No	No	5	2
416	6x46	6x47	opioid_on	0	0	No	No	No	No	6	8
417	Lig	NT	opioid_on	0	1.92308	Yes	Yes	No	No	0	0

Orange: nodes, hubs and links specific of opioid_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of opioid_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	opioid_off Avg Int. Strength	opioid_on Avg Int. Strength	opioid_off Num Of Links	opioid_on Num Of Links	ConSurf
1	1x39	opioid_off	25	0	4	3	7
2	1x42	opioid_off	0	0	4	2	7
3	1x50	opioid_off	0	0	4	3	9
4	1x60	opioid_off	8.33333	0	4	3	5
5	2x41	opioid_off	0	0	4	2	6
6	2x45	opioid_off	66.6667	0	4	3	9
7	2x57	opioid_off	25	0	4	2	7
8	3x37	opioid_off	25	34.6154	4	2	7
9	3x50	opioid_off	50	0	6	2	9
10	6x27	opioid_off	0	0	4	2	3
11	6x32	opioid_off	0	0	5	3	7
12	6x44	opioid_off	100	0	5	2	9
13	7x45	opioid_off	33.3333	25	5	3	9
14	8x54	opioid_off	0	0	4	1	6
15	Lig	Shared	100	100	16	23	0
16	2x42	Shared	91.6667	73.0769	6	5	7
17	E1x50	Shared	66.6667	91.6667	6	5	8
18	E1x52	Shared	66.6667	79.4872	5	5	7
19	3x34	Shared	16.6667	50	4	5	4
20	3x51	Shared	25	60.8974	5	4	8
21	4x50	Shared	50	40.3846	4	4	9
22	E2	Shared	100	100	12	14	4
23	5x40	Shared	0	25	4	4	4
24	5x47	Shared	0	34.6154	4	4	8
25	5x58	Shared	50	50	4	5	9
26	I3	Shared	16.6667	66.6667	5	4	4
27	6x48	Shared	75	75	6	6	8
28	E3	Shared	0	25	4	7	2
29	7x42	Shared	91.6667	40.3846	4	4	7
30	7x49	Shared	0	67.3077	4	4	9
31	7x53	Shared	66.6667	50	4	6	9
32	8x50	Shared	66.6667	23.7179	5	6	9
33	1x35	opioid_on	0	25	2	4	4
34	1x36	opioid_on	0	0	3	4	5
35	1x43	opioid_on	0	8.33333	2	4	6
36	2x44	opioid_on	0	25	3	4	6
37	2x46	opioid_on	0	36.5385	2	5	9
38	2x50	opioid_on	25	75	3	5	9
39	2x64	opioid_on	0	0	1	5	5
40	3x35	opioid_on	0	0	2	4	8
41	3x56	opioid_on	0	0	3	4	6
42	I2x56	opioid_on	0	0	2	4	4
43	5x44	opioid_on	0	36.5385	3	4	5
44	6x30	opioid_on	0	0	2	4	6
45	6x52	opioid_on	25	74.359	3	5	8
46	7x35	opioid_on	0	38.4615	3	4	4
47	7x47	opioid_on	0	0	1	4	7

Orange: nodes, hubs and links specific of opioid_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of opioid_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	opioid_off Recurrence	opioid_on Recurrence	opioid_off Hub1?	opioid_on Hub1?	opioid_off Hub2?	opioid_on Hub2?	ConSurf1	ConSurf2
1	1x39	2x57	opioid_off	43.1669	0	Yes	No	Yes	No	7	7
2	1x36	2x61	opioid_off	31.6099	1.17414	No	Yes	No	No	5	6
3	1x39	2x61	opioid_off	34.0233	0	Yes	No	No	No	7	6
4	1x36	2x65	opioid_off	24.2029	1.17414	No	Yes	No	No	5	5
5	1x42	2x57	opioid_off	13.1855	0	Yes	No	Yes	No	7	7
6	2x54	7x46	opioid_off	21.0046	0	No	No	No	No	6	9
7	2x50	7x46	opioid_off	23.9282	1.27198	No	Yes	No	No	9	9
8	2x50	7x49	opioid_off	46.6104	6.3652	No	Yes	Yes	Yes	9	9
9	6x48	Lig	opioid_off	93.162	0	Yes	Yes	Yes	Yes	8	0
10	1x50	7x50	opioid_off	12.1162	1.27198	Yes	No	No	No	9	9
11	1x50	2x50	opioid_off	21.0046	3.80537	Yes	No	No	Yes	9	9
12	2x45	4x49	opioid_off	78.8384	0	Yes	No	No	No	9	7
13	3x41	4x49	opioid_off	80.7221	2.1711	No	No	No	No	6	7
14	3x37	3x41	opioid_off	80.7613	0	Yes	No	No	No	7	6
15	3x37	5x43	opioid_off	82.0956	6.92318	Yes	No	No	No	7	5
16	5x43	Lig	opioid_off	82.4487	7.97567	No	No	Yes	Yes	5	0
17	1x55	8x57	opioid_off	23.212	0	No	No	No	No	4	5
18	1x52	8x57	opioid_off	31.4137	0	No	No	No	No	6	5
19	1x52	8x54	opioid_off	33.8762	0	No	No	Yes	No	6	6
20	8x50	8x54	opioid_off	40.8025	0.864736	Yes	Yes	Yes	No	9	6
21	1x57	8x50	opioid_off	65.8099	0	No	No	Yes	Yes	7	9
22	1x55	1x59	opioid_off	20.6907	1.06836	No	No	No	No	4	4
23	1x59	1x60	opioid_off	18.1105	2.13407	No	No	Yes	No	4	5
24	2x42	4x46	opioid_off	56.6173	6.40751	Yes	Yes	No	No	7	7
25	2x45	4x46	opioid_off	74.0606	6.25678	Yes	No	No	No	9	7
26	3x50	6x37	opioid_off	62.5429	0	Yes	No	No	No	9	7
27	5x58	6x37	opioid_off	61.6992	0.87267	Yes	Yes	No	No	9	7
28	3x47	5x58	opioid_off	71.1763	2.1711	No	No	Yes	Yes	9	9
29	3x47	5x54	opioid_off	71.6668	1.08687	No	No	No	No	9	8
30	5x54	6x41	opioid_off	73.1973	0	No	No	No	No	8	8
31	3x43	6x41	opioid_off	75.1006	0	No	No	No	No	8	8
32	3x43	6x44	opioid_off	76.582	0	No	No	Yes	No	8	9
33	6x44	6x48	opioid_off	71.971	1.88285	Yes	No	Yes	Yes	9	8
34	3x50	6x33	opioid_off	23.2709	0	Yes	No	No	No	9	7
35	2x41	4x46	opioid_off	27.1657	3.5515	Yes	No	No	No	6	7
36	2x46	7x53	opioid_off	36.7213	8.03914	No	Yes	Yes	Yes	9	9
37	2x56	3x28	opioid_off	10.6249	0	No	No	No	No	6	5
38	3x28	E1x50	opioid_off	12.695	0	No	No	Yes	Yes	5	8
39	E1x51	E1x52	opioid_off	37.722	6.60849	No	No	Yes	Yes	4	7
40	2x66	E1x51	opioid_off	40.1158	3.30557	No	No	No	No	3	4
41	2x66	E1x49	opioid_off	42.4899	0	No	No	No	No	3	5
42	E1x49	E2	opioid_off	44.3442	0.975803	No	No	Yes	Yes	5	4
43	7x34	7x38	opioid_off	38.654	0.169245	No	No	No	No	5	5
44	7x34	7x35	opioid_off	24.507	0	No	No	No	Yes	5	4
45	3x40	6x44	opioid_off	22.9079	0	No	No	Yes	No	8	9
46	3x40	5x50	opioid_off	20.1118	4.29195	No	No	No	No	8	9
47	3x49	I2x57	opioid_off	10.0854	3.25003	No	No	No	No	8	6
48	3x51	5x61	opioid_off	34.0135	0	Yes	Yes	No	No	8	8
49	3x51	3x55	opioid_off	14.4609	6.39164	Yes	Yes	No	No	8	7
50	2x41	4x39	opioid_off	24.5757	0	Yes	No	No	No	6	1
51	4x38	4x39	opioid_off	21.4461	3.25003	No	No	No	No	7	1
52	5x35	E2	opioid_off	13.2346	5.76226	No	No	Yes	Yes	3	4
53	5x34	5x35	opioid_off	10.6249	4.61986	No	No	No	No	3	3
54	5x47	6x52	opioid_off	47.925	5.02711	Yes	Yes	No	Yes	8	8
55	5x44	5x47	opioid_off	17.5513	0.163956	No	Yes	Yes	Yes	5	8
56	5x49	5x50	opioid_off	17.2962	1.07894	No	No	No	No	5	9
57	5x46	5x49	opioid_off	14.4609	0	No	No	No	No	4	5
58	5x47	5x51	opioid_off	14.0783	0.735158	Yes	Yes	No	No	8	6
59	5x47	6x49	opioid_off	14.0783	3.80537	Yes	Yes	No	No	8	5
60	6x32	6x33	opioid_off	20.3964	0	Yes	No	No	No	7	7
61	8x47	8x50	opioid_off	18.1988	3.1945	No	No	Yes	Yes	8	9
62	6x36	8x47	opioid_off	12.9795	0	No	No	No	No	8	8
63	6x36	7x56	opioid_off	10.7427	1.06836	No	No	No	No	8	6
64	6x54	7x34	opioid_off	12.6557	2.17903	No	No	No	No	4	5
65	7x31	7x35	opioid_off	19.8862	1.17414	No	No	No	Yes	4	4
66	7x31	E3	opioid_off	17.3452	0	No	No	Yes	Yes	4	2
67	3x50	6x30	opioid_off	27.4306	0	Yes	No	No	Yes	9	6
68	6x27	6x30	opioid_off	24.9387	3.25003	Yes	No	No	Yes	3	6
69	6x26	6x27	opioid_off	11.3117	0	No	No	Yes	No	4	3
70	3x55	3x56	opioid_off	11.6452	4.26021	No	No	No	Yes	7	6
71	4x38	4x41	opioid_off	15.128	7.51289	No	No	No	No	7	4
72	1x32	2x65	opioid_off	14.039	0	No	No	No	No	4	5
73	5x51	5x55	opioid_off	10.5857	0	No	No	No	No	6	4
74	3x46	6x37	opioid_off	45.7961	0	No	No	No	No	8	7
75	3x36	6x52	opioid_off	13.2346	0	No	No	No	Yes	7	8
76	6x44	7x45	opioid_off	24.6149	0	Yes	No	Yes	No	9	9
77	2x57	7x42	Shared	61.2185	19.3733	Yes	No	Yes	Yes	7	7
78	7x45	7x49	Shared	55.234	98.7518	Yes	No	Yes	Yes	9	9
79	6x48	7x45	Shared	35.4655	100	Yes	Yes	Yes	No	8	9
80	7x49	7x53	Shared	38.8109	56.7526	Yes	Yes	Yes	Yes	9	9
81	1x54	2x48	Shared	74.3648	28.137	No	No	No	No	7	6
82	2x48	4x50	Shared	76.4544	29.0546	No	No	Yes	Yes	6	9
83	2x45	4x50	Shared	100	44.6675	Yes	No	Yes	Yes	9	9
84	1x54	2x44	Shared	72.2555	27.2141	No	No	No	Yes	7	6
85	1x57	2x44	Shared	67.978	24.4136	No	No	No	Yes	7	6
86	2x42	3x49	Shared	15.3733	17.3979	Yes	Yes	No	No	7	8
87	2x42	3x46	Shared	47.2775	24.6965	Yes	Yes	No	No	7	8
88	E1x50	E1x52	Shared	25.4488	11.1093	Yes	Yes	Yes	Yes	8	7
89	E2	Lig	Shared	77.1412	17.0171	Yes	Yes	Yes	Yes	4	0
90	7x38	Lig	Shared	40.6455	24.8526	No	No	Yes	Yes	5	0
91	3x34	4x50	Shared	21.1812	15.4277	Yes	Yes	Yes	Yes	4	9
92	5x58	5x61	Shared	41.6462	37.7681	Yes	Yes	No	No	9	8
93	6x52	Lig	Shared	37.722	52.6643	No	Yes	Yes	Yes	8	0
94	7x42	Lig	Shared	62.6508	20.1904	Yes	Yes	Yes	Yes	7	0
95	3x36	6x48	Shared	13.99	47.8646	No	No	Yes	Yes	7	8
96	2x46	3x42	Shared	36.2504	44.4162	No	Yes	No	No	9	7
97	2x45	3x42	Shared	35.8776	43.7525	Yes	No	No	No	9	7
98	1x39	7x35	opioid_on	0	20.9917	Yes	No	No	Yes	7	4
99	1x39	7x38	opioid_on	0	24.046	Yes	No	No	No	7	5
100	2x64	7x35	opioid_on	2.22702	13.1482	No	Yes	No	Yes	5	4
101	2x54	7x47	opioid_on	0	11.5801	No	No	No	Yes	6	7
102	1x47	2x54	opioid_on	9.1141	12.7092	No	No	No	No	6	6
103	1x43	1x47	opioid_on	0	14.9517	No	Yes	No	No	6	6
104	1x43	2x57	opioid_on	5.32719	18.2758	No	Yes	Yes	No	6	7
105	3x36	Lig	opioid_on	1.40292	47.661	No	No	Yes	Yes	7	0
106	6x48	6x52	opioid_on	0	53.6189	Yes	Yes	No	Yes	8	8
107	1x53	1x57	opioid_on	0	23.4695	No	No	No	No	9	7
108	2x46	7x49	opioid_on	0	38.1542	No	Yes	Yes	Yes	9	9
109	1x53	7x54	opioid_on	0	21.5655	No	No	No	No	9	7
110	7x54	8x50	opioid_on	0	20.6056	No	No	Yes	Yes	7	9
111	3x46	7x53	opioid_on	0	26.5371	No	No	Yes	Yes	8	9
112	3x50	5x58	opioid_on	0	43.4642	Yes	No	Yes	Yes	9	9
113	3x50	7x53	opioid_on	0	44.1306	Yes	No	Yes	Yes	9	9
114	3x55	5x64	opioid_on	0.0392426	11.6726	No	No	No	No	7	5
115	5x64	5x68	opioid_on	0	13.73	No	No	No	No	5	6
116	5x68	I3	opioid_on	3.08055	14.7402	No	No	Yes	Yes	6	4
117	5x65	I3	opioid_on	0	26.1695	No	No	Yes	Yes	8	4
118	3x54	5x65	opioid_on	2.92357	35.9725	No	No	No	No	8	8
119	3x54	5x61	opioid_on	5.41548	36.8769	No	No	No	No	8	8
120	3x49	I2x56	opioid_on	0	13.3545	No	No	No	Yes	8	4
121	5x65	6x33	opioid_on	0	10.2261	No	No	No	No	8	7

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
3x32	Lig	Shared	21.9942	7.36987	1	1	1	0
3x33	Lig	Shared	9.58583	9.87404	1	1	1	0
3x36	Lig	Shared	10.8825	8.55199	1	1	1	0
5x40	Lig	Shared	4.21667	3.56058	1	1	1	0
5x43	Lig	Shared	5.08417	4.08603	1	1	1	0
6x48	Lig	opioid_off	4.57083	0	1	0	1	0
6x51	Lig	Shared	4.125	2.86615	1	0	1	0
6x52	Lig	Shared	5.47833	3.76141	1	1	1	0
6x55	Lig	Shared	12.4858	6.0543	1	1	1	0
7x38	Lig	Shared	4.39417	5.18737	1	1	1	0
7x42	Lig	Shared	8.33417	3.61282	1	1	1	0
1x39	2x57	opioid_off	6.18833	0	0	0	2	2
2x56	3x28	opioid_off	5.28833	0	0	0	2	1
2x57	7x42	Shared	9.66833	11.0778	0	0	2	1
2x60	7x42	Shared	9.01833	7.65276	1	1	1	1
2x63	E1x50	Shared	6.76333	5.87385	0	1	1	2
E1x49	E2	Shared	6.415	5.00449	1	0	2	1
3x25	E1x50	Shared	4.35167	5.26487	2	1	2	2
3x28	E1x50	opioid_off	3.78083	0	0	1	1	2
E1x50	E2x50	Shared	11.5375	12.0222	2	1	2	1
3x22	E2	Shared	11.5192	8.06263	1	1	2	1
3x25	E2x50	Shared	7.28	7.175	2	1	2	1
3x32	7x42	Shared	5.175	6.87769	1	1	1	1
3x33	4x60	Shared	7.37583	5.06019	1	1	1	2
3x36	6x48	Shared	8.82083	5.80314	1	1	1	1
3x36	6x52	opioid_off	4.62417	0	1	1	1	1
3x37	5x43	Shared	3.9025	3.51481	0	0	2	1
3x37	5x461	opioid_off	7.05583	0	0	0	2	2
3x40	6x44	opioid_off	5.88167	0	0	0	2	2
E2	E2	Shared	49.6258	38.5697	1	1	1	1
E2	E2x51	Shared	6.88083	4.29673	1	1	1	2
5x32	E2	Shared	4.55333	3.49987	1	0	2	1
5x35	E2	Shared	9.4225	6.5284	1	1	2	1
5x36	E2	Shared	6.735	8.42006	1	1	2	1
5x39	E2	Shared	5.3	3.44718	0	0	2	1
5x36	5x40	Shared	7.9175	5.29712	1	1	2	1
5x40	6x55	Shared	3.71583	3.38814	1	1	1	1
5x47	6x52	Shared	16.39	6.2141	0	1	2	1
6x44	6x48	Shared	18.8733	7.69551	1	0	2	1
6x44	7x45	opioid_off	6.54417	0	1	0	2	2
6x48	6x51	opioid_off	3.60167	0	1	0	1	1
6x48	7x45	Shared	5.74417	8.475	1	0	1	2
6x54	7x34	Shared	6.09	9.2907	0	0	2	1
6x58	E3	Shared	7.06417	3.78519	0	1	1	1
7x34	7x35	opioid_off	3.70333	0	0	1	1	2
7x34	7x38	Shared	5.9725	5.43756	0	1	1	1
2x60	Lig	Shared	7.12167	11.9785	1	1	1	0
5x32	5x36	opioid_off	3.63	0	1	0	2	2
6x48	7x41	Shared	5.62833	0.829359	1	0	1	2
7x31	E3	opioid_off	3.74	0	0	0	2	1
E2	Lig	Shared	4.88	12.1108	1	1	1	0
7x31	7x35	Shared	3.62833	2.32859	0	0	2	2
3x29	Lig	Shared	3.18583	5.54955	0	0	1	0
4x63	E2	Shared	2.79417	3.56205	0	0	2	1
3x33	E2x52	Shared	2.78167	2.89135	1	1	1	2
5x44	5x47	Shared	2.41167	5.88115	0	1	2	2
7x30	E3	Shared	2.36333	4.21712	0	1	2	1
1x31	NT	opioid_off	2.28167	0	0	0	2	1
6x57	6x61	opioid_off	2.215	0	0	0	2	2
5x40	6x59	Shared	2.14917	4.27378	1	1	1	2
2x67	E2	opioid_off	1.1075	0	1	0	1	1
7x28	NT	opioid_off	0.916667	0	0	0	2	1
6x57	E3	opioid_off	0.829167	0	0	0	2	1
1x28	2x67	opioid_off	0.36	0	0	0	2	1
7x34	Lig	opioid_on	0	5.41359	0	1	1	0
2x63	Lig	opioid_on	0	6.24039	0	1	1	0
3x28	Lig	opioid_on	0	3.02096	0	1	1	0
E2x50	Lig	opioid_on	0	3.79333	2	1	1	0
1x39	7x35	opioid_on	0	8.36808	0	0	2	2
1x39	7x38	opioid_on	0	4.53756	0	0	2	1
2x56	2x60	opioid_on	0	3.45256	0	0	2	1
2x56	3x32	opioid_on	0	6.03128	0	0	2	1
2x59	3x28	opioid_on	0	5.45173	2	0	2	1
3x25	E2	opioid_on	0	3.455	2	1	2	1
3x40	6x48	opioid_on	0	3.21404	0	0	2	1
5x31	E2	opioid_on	0	3.99647	0	0	2	1
5x44	6x52	opioid_on	0	6.60353	0	1	2	1
5x461	6x52	opioid_on	0	3.19359	0	0	2	1
6x48	6x52	opioid_on	0	4.17378	1	0	1	1
E3	E3	opioid_on	0	5.46474	0	1	1	1
6x54	6x58	opioid_on	0	3.97596	0	0	2	1
6x58	Lig	opioid_on	0	4.23192	0	1	1	0
E2	E3	opioid_on	0	3.77917	1	1	1	1
E3	Lig	opioid_on	0	4.5525	0	1	1	0
6x61	E3	opioid_on	0	1.94981	0	0	2	1
2x67	Lig	opioid_on	0	0.475577	1	0	1	0
Lig	NT	opioid_on	0	0.0684615	1	1	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	opioid_off	mop_off nop_off dop_off kop_off
	opioid_on	mop_on nop_on dop_on kop_on

Network Difference
Value	opioid_off	opioid_on
I_min	3.59417	2.96474
Number of Linked Nodes	274	270
Number of Specific Nodes	4 (1.46%)	0 (0.00%)
Number of Shared Nodes	270 (98.54%)	270 (100.00%)
Number of Links	294	296
Number of Specific Links	121 (41.16%)	123 (41.55%)
Number of Shared Links	173 (58.84%)	173 (58.45%)
Number of Hubs	32	33
Number of Specific Hubs	14 (43.75%)	15 (45.45%)
Number of Shared Hubs	18 (56.25%)	18 (54.55%)
Average % Shared Neighbours (Jaccard)	46.32
Average % Shared Neighbours (Otsuka)	55.55
Average % Shared Neighbours (Overlap Coefficient)	65.25
Average % Shared Cliques (k3-6)	78.85
Graphlets Similarity	0.522407

Paths Difference
Value	opioid_off	opioid_on
Number Of Nodes in MetaPath	94	46
Specific Nodes in MetaPath	60 (63.83%)	12 (26.09%)
Shared Nodes in MetaPath	270 (98.54%)	270 (98.54%)
Number Of Links MetaPath	97	45
Specific Links in MetaPath	76 (78.35%)	24 (53.33%)
Shared Links in MetaPath	173 (58.84%)	173 (58.84%)
Number of Shortest Paths	38429	58354
Length Of Smallest Path	3	3
Average Path Length	12.7195	13.9075
Length of Longest Path	31	32
Minimum Path Strength	0.40375	0.27125
Average Path Strength	5.79821	5.17267
Maximum Path Strength	15.1461	15.131
Minimum Path Correlation	0.704167	0.700513
Average Path Correlation	0.918207	0.915598
Maximum Path Correlation	0.989167	0.989167
Minimum % Of Corr. Nodes	4	3.33333
Average % Of Corr. Nodes	48.6939	43.7688
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	39.4921	43.5337
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

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Download opioid_off_on.zip<

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