psnGPCR

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Orange: nodes, hubs and links specific of opsins_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of opsins_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	opsins_off Int. Strength	opsins_on Int. Strength	opsins_off Hub1?	opsins_on Hub1?	opsins_off Hub2?	opsins_on Hub2?	ConSurf1	ConSurf2
1	E3	NT	opsins_off	100	0	Yes	Yes	Yes	Yes	0	0
2	3x21	NT	opsins_off	100	0	No	No	Yes	Yes	8	0
3	3x25	NT	opsins_off	100	0	No	No	Yes	Yes	9	0
4	2x67	NT	opsins_off	100	0	No	No	Yes	Yes	4	0
5	1x32	2x67	opsins_off	100	0	No	No	No	No	5	4
6	1x35	2x64	opsins_off	100	0	No	No	No	No	5	5
7	1x35	7x39	opsins_off	100	0	No	No	Yes	No	5	5
8	1x39	2x57	opsins_off	100	0	Yes	No	Yes	No	7	7
9	1x39	2x60	opsins_off	100	0	Yes	No	No	No	7	7
10	1x39	7x39	opsins_off	100	0	Yes	No	Yes	No	7	5
11	1x43	2x54	opsins_off	100	0	No	No	No	No	6	6
12	1x47	1x51	opsins_off	100	0	Yes	No	No	No	6	4
13	1x54	2x44	opsins_off	100	0	No	No	No	No	7	5
14	1x56	8x50	opsins_off	100	0	No	No	Yes	Yes	7	8
15	1x59	8x57	opsins_off	100	0	Yes	No	No	No	5	5
16	1x59	CT	opsins_off	100	0	Yes	No	Yes	No	5	0
17	1x60	I1x50	opsins_off	100	0	Yes	Yes	Yes	Yes	5	7
18	1x60	8x57	opsins_off	100	0	Yes	Yes	No	No	5	5
19	1x60	CT	opsins_off	100	0	Yes	Yes	Yes	No	5	0
20	CT	I1x48	opsins_off	100	0	Yes	No	No	No	0	6
21	CT	I1x49	opsins_off	100	0	Yes	No	No	No	0	5
22	2x40	I1x50	opsins_off	100	0	No	No	Yes	Yes	8	7
23	8x49	I1x50	opsins_off	100	0	Yes	No	Yes	Yes	6	7
24	2x41	I1x51	opsins_off	100	0	Yes	No	No	No	5	6
25	4x39	I1x51	opsins_off	100	0	No	No	No	No	2	6
26	2x38	3x49	opsins_off	100	0	Yes	No	No	No	6	8
27	2x38	I2x56	opsins_off	100	0	Yes	No	Yes	Yes	6	7
28	2x39	6x33	opsins_off	100	0	No	No	No	No	8	8
29	2x40	7x53	opsins_off	100	0	No	No	Yes	Yes	8	9
30	2x41	4x43	opsins_off	100	0	Yes	No	No	No	5	3
31	2x43	6x40	opsins_off	100	0	No	No	No	No	8	8
32	2x43	7x53	opsins_off	100	0	No	No	Yes	Yes	8	9
33	2x46	7x49	opsins_off	100	0	No	No	No	No	9	9
34	2x52	3x31	opsins_off	100	0	No	No	Yes	No	6	4
35	2x53	3x35	opsins_off	100	0	No	No	No	No	7	8
36	2x551	3x31	opsins_off	100	0	No	No	Yes	No	4	4
37	2x59	3x27	opsins_off	100	0	No	No	No	No	5	4
38	2x61	2x65	opsins_off	100	0	No	No	No	No	6	4
39	2x62	E1x51	opsins_off	100	0	No	No	Yes	No	4	4
40	2x62	E1x52	opsins_off	100	0	No	No	No	No	4	7
41	2x66	E1x51	opsins_off	100	0	No	No	Yes	No	4	4
42	E1x50	E2	opsins_off	100	0	No	Yes	Yes	Yes	8	0
43	E1x51	E1x52	opsins_off	100	0	Yes	No	No	No	4	7
44	3x26	4x61	opsins_off	100	0	No	No	No	No	7	5
45	3x28	7x42	opsins_off	100	0	No	Yes	Yes	No	5	7
46	3x28	Lig	opsins_off	100	0	No	Yes	Yes	Yes	5	0
47	3x30	3x31	opsins_off	100	0	Yes	Yes	Yes	No	6	4
48	3x30	3x34	opsins_off	100	0	Yes	Yes	No	No	6	5
49	3x33	Lig	opsins_off	100	0	No	No	Yes	Yes	4	0
50	3x36	6x48	opsins_off	100	0	No	No	Yes	Yes	7	8
51	3x37	3x40	opsins_off	100	0	Yes	Yes	No	No	6	7
52	3x37	Lig	opsins_off	100	0	Yes	Yes	Yes	Yes	6	0
53	3x38	4x53	opsins_off	100	0	No	No	No	No	7	8
54	3x40	5x50	opsins_off	100	0	No	No	No	No	7	9
55	3x42	4x49	opsins_off	100	0	No	Yes	No	No	8	7
56	3x43	6x41	opsins_off	100	0	No	No	No	No	8	8
57	3x43	6x44	opsins_off	100	0	No	No	Yes	Yes	8	9
58	3x44	5x54	opsins_off	100	0	No	No	No	No	7	8
59	3x46	6x37	opsins_off	100	0	No	No	No	No	9	8
60	3x49	3x50	opsins_off	100	0	No	No	Yes	No	8	9
61	3x50	3x53	opsins_off	100	0	Yes	No	No	No	9	8
62	3x50	6x30	opsins_off	100	0	Yes	No	No	Yes	9	7
63	3x50	6x33	opsins_off	100	0	Yes	No	No	No	9	8
64	3x50	6x34	opsins_off	100	0	Yes	No	No	No	9	6
65	3x50	6x37	opsins_off	100	0	Yes	No	No	No	9	8
66	3x54	5x64	opsins_off	100	0	No	No	No	No	8	6
67	3x54	5x65	opsins_off	100	0	No	No	No	No	8	8
68	3x55	5x60	opsins_off	100	0	No	No	No	No	7	4
69	4x59	5x39	opsins_off	100	0	No	No	Yes	Yes	7	6
70	E2	E2x50	opsins_off	100	0	Yes	Yes	No	No	0	9
71	7x39	E2	opsins_off	100	0	Yes	No	Yes	Yes	5	0
72	E2	Lig	opsins_off	100	0	Yes	Yes	Yes	Yes	0	0
73	6x58	E2	opsins_off	100	0	No	No	Yes	Yes	4	0
74	5x37	E2	opsins_off	100	0	No	No	Yes	Yes	3	0
75	5x37	E3	opsins_off	100	0	No	No	Yes	Yes	3	0
76	5x39	5x42	opsins_off	100	0	Yes	Yes	Yes	No	6	4
77	5x40	6x59	opsins_off	100	0	No	No	No	No	4	4
78	5x42	5x461	opsins_off	100	0	Yes	No	Yes	Yes	4	6
79	5x43	5x44	opsins_off	100	0	No	Yes	No	No	5	5
80	5x44	6x56	opsins_off	100	0	No	No	No	No	5	6
81	5x47	5x51	opsins_off	100	0	No	No	No	No	8	7
82	5x47	Lig	opsins_off	100	0	No	No	Yes	Yes	8	0
83	5x54	6x41	opsins_off	100	0	No	No	No	No	8	8
84	5x58	6x38	opsins_off	100	0	No	Yes	No	No	9	5
85	5x65	6x31	opsins_off	100	0	No	No	Yes	No	8	4
86	5x65	6x34	opsins_off	100	0	No	No	No	No	8	6
87	5x67	6x35	opsins_off	100	0	No	No	No	No	4	7
88	5x70	I3	opsins_off	100	0	No	No	Yes	No	4	0
89	5x71	5x72	opsins_off	100	0	No	No	No	No	2	5
90	6x25	I3	opsins_off	100	0	No	No	Yes	No	4	0
91	6x27	I3	opsins_off	100	0	No	No	Yes	No	4	0
92	6x28	I3	opsins_off	100	0	No	No	Yes	No	4	0
93	6x31	I3	opsins_off	100	0	Yes	No	Yes	No	4	0
94	6x23	6x27	opsins_off	100	0	No	No	No	No	4	4
95	6x27	6x31	opsins_off	100	0	No	No	Yes	No	4	4
96	6x28	6x31	opsins_off	100	0	No	No	Yes	No	4	4
97	6x39	7x56	opsins_off	100	0	No	No	No	No	5	7
98	6x40	7x49	opsins_off	100	0	No	No	No	No	8	9
99	6x48	7x41	opsins_off	100	0	Yes	Yes	No	No	8	8
100	6x48	7x45	opsins_off	100	0	Yes	Yes	No	No	8	9
101	6x51	7x34	opsins_off	100	0	No	Yes	No	No	6	4
102	6x54	7x33	opsins_off	100	0	No	No	No	No	5	4
103	6x54	7x34	opsins_off	100	0	No	No	No	No	5	4
104	6x57	7x33	opsins_off	100	0	No	No	No	No	4	4
105	6x61	E3	opsins_off	100	0	No	No	Yes	Yes	3	0
106	7x39	7x42	opsins_off	100	0	Yes	No	Yes	No	5	7
107	7x48	7x49	opsins_off	100	0	No	No	No	No	5	9
108	7x53	8x47	opsins_off	100	0	Yes	Yes	Yes	No	9	8
109	7x53	8x50	opsins_off	100	0	Yes	Yes	Yes	Yes	9	8
110	7x54	8x54	opsins_off	100	0	No	Yes	Yes	No	7	6
111	8x48	8x51	opsins_off	100	0	No	No	No	No	4	8
112	8x48	8x52	opsins_off	100	0	No	No	No	No	4	5
113	8x48	CT	opsins_off	100	0	No	No	Yes	No	4	0
114	8x49	CT	opsins_off	100	0	Yes	No	Yes	No	6	0
115	8x52	CT	opsins_off	100	0	No	No	Yes	No	5	0
116	8x56	CT	opsins_off	100	0	No	No	Yes	No	4	0
117	CT	CT	opsins_off	100	0	Yes	No	Yes	No	0	0
118	8x49	I1x49	opsins_off	100	0	Yes	No	No	No	6	5
119	6x36	8x47	opsins_off	33.3333	0	No	No	Yes	No	8	8
120	2x53	2x57	opsins_off	33.3333	0	No	No	Yes	No	7	7
121	3x52	I2x56	opsins_off	33.3333	0	No	No	Yes	Yes	4	7
122	1x53	8x50	opsins_off	33.3333	0	No	No	Yes	Yes	9	8
123	1x43	2x57	opsins_off	0	0	No	No	Yes	No	6	7
124	8x54	8x58	opsins_off	66.6667	0	Yes	No	No	No	6	6
125	2x59	3x24	opsins_off	0	0	No	No	No	No	5	5
126	7x32	7x36	opsins_off	0	0	No	No	No	No	1	5
127	4x55	5x461	opsins_off	0	0	No	No	Yes	Yes	4	6
128	1x53	7x50	opsins_off	0	0	No	No	No	No	9	9
129	1x40	2x61	opsins_off	0	0	No	No	No	No	3	6
130	6x47	7x43	opsins_off	0	0	No	No	No	No	8	6
131	1x30	1x34	opsins_off	33.3333	0	Yes	No	No	No	3	4
132	5x66	5x68	opsins_off	33.3333	0	No	No	No	No	5	5
133	4x50	4x54	opsins_off	33.3333	0	Yes	Yes	No	No	9	3
134	2x48	2x52	opsins_off	0	0	No	No	No	No	6	6
135	1x57	8x50	opsins_off	0	0	No	No	Yes	Yes	7	8
136	5x35	5x38	opsins_off	0	0	No	No	No	No	3	4
137	1x46	7x47	opsins_off	0	0	No	No	No	No	8	7
138	5x59	5x62	opsins_off	0	0	No	No	No	No	3	5
139	5x48	5x52	opsins_off	0	0	No	No	No	No	4	4
140	1x40	1x41	opsins_off	0	0	No	No	No	No	3	5
141	5x58	5x67	opsins_off	33.3333	0	No	Yes	No	No	9	4
142	5x69	6x28	opsins_off	33.3333	0	No	No	No	No	5	4
143	5x69	6x31	opsins_off	33.3333	0	No	No	Yes	No	5	4
144	4x38	4x41	opsins_off	33.3333	0	No	No	Yes	No	6	5
145	6x52	Lig	opsins_off	0	0	No	No	Yes	Yes	7	0
146	5x45	5x48	opsins_off	0	0	No	No	No	No	5	4
147	5x45	5x49	opsins_off	0	0	No	No	No	No	5	5
148	4x43	4x44	opsins_off	0	0	No	No	No	No	3	2
149	2x38	4x42	opsins_off	33.3333	0	Yes	No	No	No	6	7
150	3x39	6x44	opsins_off	0	0	No	No	Yes	Yes	9	9
151	5x69	6x35	opsins_off	33.3333	0	No	No	No	No	5	7
152	5x51	6x45	opsins_off	0	0	No	No	No	No	7	6
153	3x53	I2x55	opsins_off	33.3333	0	No	No	No	No	8	4
154	7x40	7x43	opsins_off	0	0	No	No	No	No	7	6
155	5x63	5x64	opsins_off	33.3333	0	No	No	No	No	3	6
156	6x24	6x26	opsins_off	0	0	No	No	No	No	3	5
157	6x46	7x40	opsins_off	0	0	No	No	No	No	5	7
158	1x45	1x49	opsins_off	0	0	No	No	No	No	5	8
159	6x32	8x47	opsins_off	33.3333	0	No	No	Yes	No	7	8
160	8x55	8x59	opsins_off	0	0	No	No	No	No	3	4
161	8x59	CT	opsins_off	0	0	No	No	Yes	No	4	0
162	5x70	5x71	opsins_off	0	0	No	No	No	No	4	2
163	1x54	1x58	opsins_off	0	0	No	No	No	No	7	2
164	1x58	2x44	opsins_off	0	0	No	No	No	No	2	5
165	I2x52	I2x53	opsins_off	0	0	No	No	No	No	4	5
166	4x61	4x62	opsins_off	0	0	No	No	No	No	5	4
167	5x58	5x59	opsins_off	0	0	No	Yes	No	No	9	3
168	1x49	7x51	opsins_off	0	0	No	No	No	No	8	7
169	3x56	I2x52	opsins_off	0	0	No	No	No	No	6	4
170	4x51	4x52	opsins_off	0	0	No	No	No	No	4	4
171	6x29	CT	opsins_off	0	0	No	No	Yes	No	6	0
172	5x66	5x67	opsins_off	0	0	No	No	No	No	5	4
173	1x30	1x33	opsins_off	0	0	Yes	No	No	No	3	2
174	NT	NT	Shared	100	100	Yes	Yes	Yes	Yes	0	0
175	E2	NT	Shared	100	100	Yes	Yes	Yes	Yes	0	0
176	3x22	NT	Shared	100	100	No	No	Yes	Yes	3	0
177	7x31	NT	Shared	100	100	No	No	Yes	Yes	3	0
178	E1x49	NT	Shared	100	100	No	No	Yes	Yes	4	0
179	1x32	NT	Shared	100	100	No	No	Yes	Yes	5	0
180	1x29	NT	Shared	100	100	No	No	Yes	Yes	3	0
181	1x28	1x30	Shared	100	100	No	No	Yes	No	3	3
182	1x28	1x31	Shared	100	100	No	No	No	No	3	2
183	1x30	1x31	Shared	100	100	Yes	No	No	No	3	2
184	1x32	E2	Shared	100	100	No	No	Yes	Yes	5	0
185	1x35	E2	Shared	100	100	No	No	Yes	Yes	5	0
186	1x38	1x42	Shared	100	100	No	Yes	No	No	4	7
187	1x39	2x61	Shared	100	0	Yes	No	No	No	7	6
188	1x40	1x44	Shared	100	100	No	No	No	No	3	5
189	1x42	2x57	Shared	100	100	No	No	Yes	No	7	7
190	1x47	1x48	Shared	100	50	Yes	No	No	No	6	4
191	1x47	2x55	Shared	100	50	Yes	No	No	No	6	4
192	1x49	7x50	Shared	100	100	No	No	No	No	8	9
193	1x50	2x50	Shared	100	100	No	Yes	No	Yes	9	9
194	1x50	7x50	Shared	100	100	No	Yes	No	No	9	9
195	1x52	8x54	Shared	100	100	No	No	Yes	No	6	6
196	1x55	1x59	Shared	100	100	No	No	Yes	No	3	5
197	1x56	8x57	Shared	100	50	No	No	No	No	7	5
198	1x57	2x44	Shared	100	100	No	No	No	No	7	5
199	1x59	1x60	Shared	100	100	Yes	No	Yes	Yes	5	5
200	1x60	8x53	Shared	100	100	Yes	Yes	No	No	5	5
201	8x53	I1x50	Shared	100	100	No	No	Yes	Yes	5	7
202	2x37	2x38	Shared	100	100	No	No	Yes	No	7	6
203	2x37	2x40	Shared	100	100	No	No	No	No	7	8
204	2x41	4x39	Shared	100	100	Yes	No	No	No	5	2
205	2x41	4x42	Shared	100	50	Yes	No	No	No	5	7
206	2x42	3x42	Shared	100	100	No	Yes	No	Yes	7	8
207	2x42	3x45	Shared	100	100	No	Yes	No	No	7	7
208	2x42	3x46	Shared	100	100	No	Yes	No	No	7	9
209	2x45	4x46	Shared	100	100	No	Yes	No	No	9	7
210	2x45	4x49	Shared	100	100	No	Yes	No	No	9	7
211	2x45	4x50	Shared	100	100	No	Yes	Yes	Yes	9	9
212	2x46	3x42	Shared	100	100	No	No	No	Yes	9	8
213	2x49	3x38	Shared	100	0	No	No	No	No	8	7
214	2x52	4x50	Shared	100	50	No	No	Yes	Yes	6	9
215	2x53	7x46	Shared	100	100	No	No	No	No	7	9
216	2x57	7x42	Shared	100	100	Yes	No	Yes	No	7	7
217	2x60	3x28	Shared	100	100	No	No	No	Yes	7	5
218	2x62	2x66	Shared	100	0	No	No	No	No	4	4
219	2x63	E1x50	Shared	100	100	No	No	No	Yes	5	8
220	2x64	E2	Shared	100	100	No	No	Yes	Yes	5	0
221	E1x49	E1x51	Shared	100	100	No	No	Yes	No	4	4
222	E1x50	E2x50	Shared	100	100	No	Yes	No	No	8	9
223	3x21	3x22	Shared	100	50	No	No	No	No	8	3
224	3x25	E2x50	Shared	100	100	No	No	No	No	9	9
225	3x26	E2	Shared	100	100	No	No	Yes	Yes	7	0
226	3x29	E2	Shared	100	100	No	No	Yes	Yes	5	0
227	3x30	4x61	Shared	100	100	Yes	Yes	No	No	6	5
228	3x32	Lig	Shared	100	50	No	No	Yes	Yes	5	0
229	3x33	E2	Shared	100	100	No	No	Yes	Yes	4	0
230	3x37	3x41	Shared	100	100	Yes	Yes	Yes	Yes	6	5
231	3x37	5x461	Shared	100	100	Yes	Yes	Yes	Yes	6	6
232	3x38	4x50	Shared	100	100	No	No	Yes	Yes	7	9
233	3x40	6x44	Shared	100	100	No	No	Yes	Yes	7	9
234	3x41	3x44	Shared	100	100	Yes	Yes	No	No	5	7
235	3x41	4x48	Shared	100	100	Yes	Yes	No	No	5	3
236	3x41	4x52	Shared	100	100	Yes	Yes	No	No	5	4
237	3x41	5x461	Shared	100	100	Yes	Yes	Yes	Yes	5	6
238	3x41	5x50	Shared	100	100	Yes	Yes	No	No	5	9
239	3x45	4x45	Shared	100	50	No	No	No	No	7	6
240	3x49	I2x56	Shared	100	100	No	No	Yes	Yes	8	7
241	3x51	3x55	Shared	100	100	Yes	Yes	No	No	7	7
242	3x51	I2x50	Shared	100	100	Yes	Yes	No	Yes	7	8
243	3x51	5x60	Shared	100	100	Yes	Yes	No	No	7	4
244	3x54	5x61	Shared	100	100	No	No	No	No	8	8
245	I2x51	I2x54	Shared	100	100	No	No	No	No	6	5
246	4x41	I2x54	Shared	100	100	Yes	No	No	No	5	5
247	4x41	I2x56	Shared	100	100	Yes	No	Yes	Yes	5	7
248	4x40	4x41	Shared	100	0	No	No	Yes	No	4	5
249	4x48	4x52	Shared	100	100	No	No	No	No	3	4
250	4x56	5x461	Shared	100	100	No	Yes	Yes	Yes	5	6
251	4x59	4x60	Shared	100	100	No	No	No	No	7	5
252	4x60	E2	Shared	100	100	No	No	Yes	Yes	5	0
253	4x60	5x39	Shared	100	100	No	No	Yes	Yes	5	6
254	5x38	E2	Shared	100	100	No	No	Yes	Yes	4	0
255	5x39	E2	Shared	100	100	Yes	Yes	Yes	Yes	6	0
256	5x42	E2	Shared	100	100	Yes	No	Yes	Yes	4	0
257	E2	E2x52	Shared	100	100	Yes	Yes	No	No	0	4
258	E2	E2	Shared	100	100	Yes	Yes	Yes	Yes	0	0
259	5x36	E2	Shared	100	100	No	No	Yes	Yes	4	0
260	E2	E2x51	Shared	100	100	Yes	Yes	No	No	0	5
261	6x51	E2	Shared	100	100	No	Yes	Yes	Yes	6	0
262	7x34	E2	Shared	100	100	No	No	Yes	Yes	4	0
263	7x35	E2	Shared	100	100	No	No	Yes	Yes	4	0
264	5x39	E2x52	Shared	100	100	Yes	Yes	No	No	6	4
265	6x55	E2	Shared	100	0	No	No	Yes	Yes	5	0
266	E2	E3	Shared	100	100	Yes	Yes	Yes	Yes	0	0
267	5x37	6x59	Shared	100	100	No	No	No	No	3	4
268	5x42	5x46	Shared	100	100	Yes	No	No	Yes	4	4
269	5x46	5x461	Shared	100	100	No	Yes	Yes	Yes	4	6
270	5x49	5x50	Shared	100	100	No	No	No	No	5	9
271	5x56	5x60	Shared	100	50	No	No	No	No	4	4
272	6x36	7x56	Shared	100	100	No	No	No	No	8	7
273	6x39	7x52	Shared	100	100	No	No	No	No	5	8
274	6x43	7x48	Shared	100	50	No	No	No	No	7	5
275	6x44	6x48	Shared	100	100	Yes	Yes	Yes	Yes	9	8
276	6x45	6x49	Shared	100	50	No	No	No	No	6	6
277	6x48	Lig	Shared	100	100	Yes	Yes	Yes	Yes	8	0
278	6x50	7x40	Shared	100	100	No	No	No	No	9	7
279	6x51	Lig	Shared	100	100	No	Yes	Yes	Yes	6	0
280	6x54	7x37	Shared	100	100	No	No	No	No	5	6
281	6x56	6x60	Shared	100	100	No	No	No	No	6	5
282	6x57	6x61	Shared	100	100	No	No	No	No	4	3
283	6x58	E3	Shared	100	100	No	No	Yes	Yes	4	0
284	6x60	6x61	Shared	100	50	No	No	No	No	5	3
285	7x33	E3	Shared	100	100	No	No	Yes	Yes	4	0
286	7x30	7x31	Shared	100	100	No	No	No	No	4	3
287	7x42	Lig	Shared	100	100	Yes	No	Yes	Yes	7	0
288	8x47	8x49	Shared	100	100	Yes	No	Yes	No	8	6
289	7x36	7x37	Shared	33.3333	0	No	No	No	No	5	6
290	1x36	2x65	Shared	33.3333	50	No	No	No	No	5	4
291	1x28	1x29	Shared	33.3333	50	No	No	No	No	3	3
292	1x50	2x51	Shared	33.3333	100	No	Yes	No	No	9	7
293	5x51	5x55	Shared	33.3333	100	No	No	No	No	7	5
294	3x47	5x57	Shared	0	100	No	No	No	No	9	8
295	1x56	8x54	Shared	33.3333	0	No	No	Yes	No	7	6
296	2x56	3x31	Shared	33.3333	50	No	No	Yes	No	6	4
297	6x47	6x48	Shared	66.6667	100	No	No	Yes	Yes	8	8
298	1x53	2x47	Shared	0	50	No	No	No	No	9	9
299	3x30	4x57	Shared	33.3333	100	Yes	Yes	No	No	6	7
300	3x55	5x61	Shared	0	0	No	No	No	No	7	8
301	1x47	2x51	Shared	33.3333	50	Yes	No	No	No	6	7
302	7x38	E2	Shared	33.3333	50	No	No	Yes	Yes	5	0
303	3x51	5x57	Shared	33.3333	100	Yes	Yes	No	No	7	8
304	3x44	5x53	Shared	0	100	No	No	No	No	7	6
305	7x51	7x55	Shared	0	50	No	No	No	No	7	6
306	5x41	6x59	Shared	0	100	No	No	No	No	5	4
307	1x46	2x54	Shared	0	100	No	No	No	No	8	6
308	6x23	6x26	Shared	33.3333	100	No	No	No	No	4	5
309	3x27	3x31	Shared	0	50	No	No	Yes	No	4	4
310	6x42	6x46	Shared	0	100	No	No	No	No	5	5
311	4x58	4x59	Shared	0	0	No	No	No	No	3	7
312	3x23	3x24	Shared	0	0	No	No	No	No	1	5
313	4x63	E2	Shared	0	50	No	No	Yes	Yes	5	0
314	3x48	3x52	Shared	0	100	No	No	No	No	6	4
315	6x52	6x53	Shared	0	50	No	No	No	No	7	5
316	3x56	I2x50	Shared	0	0	No	No	No	Yes	6	8
317	2x58	2x59	Shared	0	100	No	No	No	No	8	5
318	E1x50	NT	opsins_on	0	100	No	Yes	Yes	Yes	8	0
319	1x38	7x39	opsins_on	0	100	No	Yes	Yes	No	4	5
320	1x38	7x43	opsins_on	0	100	No	Yes	No	No	4	6
321	1x42	7x47	opsins_on	0	100	No	No	No	No	7	7
322	1x43	2x58	opsins_on	0	100	No	No	No	No	6	8
323	1x49	1x50	opsins_on	0	100	No	No	No	Yes	8	9
324	1x53	7x54	opsins_on	0	100	No	No	No	Yes	9	7
325	1x57	I1x50	opsins_on	0	100	No	No	Yes	Yes	7	7
326	1x60	I1x49	opsins_on	0	100	Yes	Yes	No	No	5	5
327	I1x48	I1x51	opsins_on	0	100	No	No	No	No	6	6
328	8x50	I1x50	opsins_on	0	100	Yes	Yes	Yes	Yes	8	7
329	2x39	3x49	opsins_on	0	100	No	No	No	No	8	8
330	2x39	I2x56	opsins_on	0	100	No	No	Yes	Yes	8	7
331	2x40	2x43	opsins_on	0	100	No	No	No	No	8	8
332	2x40	8x50	opsins_on	0	100	No	No	Yes	Yes	8	8
333	2x42	3x49	opsins_on	0	100	No	Yes	No	No	7	8
334	2x43	7x54	opsins_on	0	100	No	No	No	Yes	8	7
335	2x46	2x50	opsins_on	0	100	No	No	No	Yes	9	9
336	2x46	3x43	opsins_on	0	100	No	No	No	No	9	8
337	2x50	7x46	opsins_on	0	100	No	Yes	No	No	9	9
338	2x50	7x49	opsins_on	0	100	No	Yes	No	No	9	9
339	2x53	3x36	opsins_on	0	100	No	No	No	No	7	7
340	2x54	2x57	opsins_on	0	100	No	No	Yes	No	6	7
341	2x59	3x28	opsins_on	0	100	No	No	No	Yes	5	5
342	E1x50	E1x52	opsins_on	0	100	No	Yes	No	No	8	7
343	3x25	E1x50	opsins_on	0	100	No	No	No	Yes	9	8
344	3x24	E1x52	opsins_on	0	100	No	No	No	No	5	7
345	3x28	E2x50	opsins_on	0	100	No	Yes	No	No	5	9
346	3x30	E2	opsins_on	0	100	Yes	Yes	Yes	Yes	6	0
347	3x33	4x57	opsins_on	0	100	No	No	No	No	4	7
348	3x37	4x56	opsins_on	0	100	Yes	Yes	No	Yes	6	5
349	3x40	6x48	opsins_on	0	100	No	No	Yes	Yes	7	8
350	3x43	7x49	opsins_on	0	100	No	No	No	No	8	9
351	3x43	7x53	opsins_on	0	100	No	No	Yes	Yes	8	9
352	3x46	3x50	opsins_on	0	100	No	No	Yes	No	9	9
353	3x46	7x53	opsins_on	0	100	No	No	Yes	Yes	9	9
354	3x47	5x54	opsins_on	0	100	No	No	No	No	9	8
355	3x47	5x58	opsins_on	0	100	No	No	No	Yes	9	9
356	3x50	5x58	opsins_on	0	100	Yes	No	No	Yes	9	9
357	3x50	7x53	opsins_on	0	100	Yes	No	Yes	Yes	9	9
358	3x52	I2x50	opsins_on	0	100	No	No	No	Yes	4	8
359	4x49	4x50	opsins_on	0	100	No	No	Yes	Yes	7	9
360	4x56	5x43	opsins_on	0	100	No	Yes	No	Yes	5	5
361	4x59	E2	opsins_on	0	100	No	No	Yes	Yes	7	0
362	E2x52	Lig	opsins_on	0	100	No	No	Yes	Yes	4	0
363	5x40	E2	opsins_on	0	100	No	No	Yes	Yes	4	0
364	6x54	E2	opsins_on	0	100	No	No	Yes	Yes	5	0
365	5x39	5x43	opsins_on	0	100	Yes	Yes	No	Yes	6	5
366	5x43	5x461	opsins_on	0	100	No	Yes	Yes	Yes	5	6
367	5x43	Lig	opsins_on	0	100	No	Yes	Yes	Yes	5	0
368	5x44	5x48	opsins_on	0	100	No	No	No	No	5	4
369	5x47	6x52	opsins_on	0	100	No	No	No	No	8	7
370	5x51	6x44	opsins_on	0	100	No	No	Yes	Yes	7	9
371	5x54	6x44	opsins_on	0	100	No	No	Yes	Yes	8	9
372	5x55	6x41	opsins_on	0	100	No	No	No	No	5	8
373	5x58	6x37	opsins_on	0	100	No	Yes	No	No	9	8
374	5x58	6x40	opsins_on	0	100	No	Yes	No	No	9	8
375	5x60	5x63	opsins_on	0	100	No	No	No	No	4	3
376	5x65	6x33	opsins_on	0	100	No	No	No	No	8	8
377	6x30	6x31	opsins_on	0	100	No	Yes	Yes	No	7	4
378	6x32	6x35	opsins_on	0	100	No	No	No	No	7	7
379	6x40	7x53	opsins_on	0	100	No	No	Yes	Yes	8	9
380	6x47	7x45	opsins_on	0	100	No	No	No	No	8	9
381	6x47	7x48	opsins_on	0	100	No	No	No	No	8	5
382	6x51	7x37	opsins_on	0	100	No	Yes	No	No	6	6
383	6x57	E3	opsins_on	0	100	No	No	Yes	Yes	4	0
384	E3	E3	opsins_on	0	100	Yes	Yes	Yes	Yes	0	0
385	7x45	7x49	opsins_on	0	100	No	No	No	No	9	9
386	7x52	7x53	opsins_on	0	100	No	No	Yes	Yes	8	9
387	7x54	8x50	opsins_on	0	100	No	Yes	Yes	Yes	7	8
388	7x55	8x54	opsins_on	0	100	No	No	Yes	No	6	6
389	8x47	8x50	opsins_on	0	100	Yes	No	Yes	Yes	8	8
390	1x29	1x33	opsins_on	0	100	No	No	No	No	3	2
391	2x39	3x53	opsins_on	0	100	No	No	No	No	8	8
392	2x64	E1x50	opsins_on	0	100	No	No	No	Yes	5	8
393	2x65	E2	opsins_on	0	100	No	No	Yes	Yes	4	0
394	2x67	E1x51	opsins_on	0	100	No	No	Yes	No	4	4
395	3x56	I2x55	opsins_on	0	100	No	No	No	No	6	4
396	I2x50	I2x51	opsins_on	0	100	No	Yes	No	No	8	6
397	4x38	4x40	opsins_on	0	100	No	No	No	No	6	4
398	4x52	4x56	opsins_on	0	100	No	No	No	Yes	4	5
399	4x56	5x46	opsins_on	0	100	No	Yes	No	Yes	5	4
400	5x62	6x34	opsins_on	0	100	No	No	No	No	5	6
401	5x66	5x70	opsins_on	0	100	No	No	No	No	5	4
402	6x54	E3	opsins_on	0	100	No	No	Yes	Yes	5	0
403	5x35	E2	opsins_on	0	50	No	No	Yes	Yes	3	0
404	1x45	7x47	opsins_on	0	50	No	No	No	No	5	7
405	5x69	6x27	opsins_on	0	50	No	No	No	No	5	4
406	2x45	3x42	opsins_on	0	50	No	Yes	No	Yes	9	8
407	1x38	1x39	opsins_on	0	50	No	Yes	Yes	No	4	7
408	5x66	6x30	opsins_on	0	50	No	No	No	Yes	5	7
409	5x72	6x23	opsins_on	0	50	No	No	No	No	5	4
410	6x36	6x40	opsins_on	0	50	No	No	No	No	8	8
411	6x49	6x50	opsins_on	0	50	No	No	No	No	6	9
412	6x30	6x34	opsins_on	0	50	No	Yes	No	No	7	6
413	6x24	6x28	opsins_on	0	50	No	No	No	No	3	4
414	6x51	7x41	opsins_on	0	50	No	Yes	No	No	6	8
415	3x55	5x64	opsins_on	0	0	No	No	No	No	7	6
416	2x52	3x35	opsins_on	0	50	No	No	No	No	6	8
417	7x50	7x54	opsins_on	0	50	No	No	No	Yes	9	7
418	6x35	6x39	opsins_on	0	50	No	No	No	No	7	5
419	2x56	3x28	opsins_on	0	50	No	No	No	Yes	6	5
420	5x62	6x37	opsins_on	0	50	No	No	No	No	5	8
421	3x37	4x53	opsins_on	0	50	Yes	Yes	No	No	6	8
422	5x37	6x62	opsins_on	0	50	No	No	No	No	3	0
423	1x60	8x56	opsins_on	0	50	Yes	Yes	No	No	5	4
424	1x56	I1x50	opsins_on	0	0	No	No	Yes	Yes	7	7
425	3x34	4x50	opsins_on	0	50	No	No	Yes	Yes	5	9
426	5x69	6x30	opsins_on	0	0	No	No	No	Yes	5	7
427	5x44	5x47	opsins_on	0	50	No	No	No	No	5	8
428	7x39	7x40	opsins_on	0	50	Yes	No	No	No	5	7
429	5x65	6x30	opsins_on	0	50	No	No	No	Yes	8	7
430	1x57	I1x51	opsins_on	0	50	No	No	No	No	7	6
431	5x67	5x71	opsins_on	0	50	No	No	No	No	4	2
432	3x30	4x54	opsins_on	0	0	Yes	Yes	No	No	6	3
433	7x56	8x51	opsins_on	0	50	No	No	No	No	7	8
434	3x39	3x42	opsins_on	0	50	No	No	No	Yes	9	8
435	6x49	6x52	opsins_on	0	50	No	No	No	No	6	7
436	8x51	8x52	opsins_on	0	0	No	No	No	No	8	5
437	8x51	CT	opsins_on	0	0	No	No	Yes	No	8	0
438	5x69	6x26	opsins_on	0	0	No	No	No	No	5	5
439	6x23	6x25	opsins_on	0	50	No	No	No	No	4	4
440	4x42	I2x56	opsins_on	0	50	No	No	Yes	Yes	7	7
441	4x58	4x62	opsins_on	0	50	No	No	No	No	3	4
442	1x54	2x51	opsins_on	0	0	No	No	No	No	7	7
443	1x37	1x41	opsins_on	0	50	No	No	No	No	5	5
444	6x46	7x48	opsins_on	0	0	No	No	No	No	5	5
445	2x551	2x56	opsins_on	0	0	No	No	No	No	4	6
446	1x51	1x55	opsins_on	0	0	No	No	No	No	4	3
447	2x67	2x68	opsins_on	0	0	No	No	No	No	4	0
448	6x61	6x62	opsins_on	0	0	No	No	No	No	3	0
449	1x36	1x37	opsins_on	0	0	No	No	No	No	5	5
450	5x45	5x46	opsins_on	0	0	No	No	No	Yes	5	4
451	5x68	6x26	opsins_on	0	0	No	No	No	No	5	5
452	7x32	7x35	opsins_on	0	0	No	No	No	No	1	4
453	I2x52	I2x55	opsins_on	0	0	No	No	No	No	4	4
454	1x54	2x48	opsins_on	0	0	No	No	No	No	7	6
455	1x40	2x62	opsins_on	0	0	No	No	No	No	3	4
456	1x58	1x59	opsins_on	0	0	No	No	Yes	No	2	5
457	5x59	5x63	opsins_on	0	0	No	No	No	No	3	3
458	4x39	4x43	opsins_on	0	0	No	No	No	No	2	3
459	4x55	5x42	opsins_on	0	0	No	No	Yes	No	4	4
460	4x48	4x51	opsins_on	0	0	No	No	No	No	3	4
461	1x40	1x43	opsins_on	0	0	No	No	No	No	3	6
462	5x63	5x67	opsins_on	0	0	No	No	No	No	3	4

Orange: nodes, hubs and links specific of opsins_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of opsins_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	opsins_off Avg Int. Strength	opsins_on Avg Int. Strength	opsins_off Num Of Links	opsins_on Num Of Links	ConSurf
1	1x30	opsins_off	0	0	4	2	3
2	1x39	opsins_off	66.6667	0	4	2	7
3	1x47	opsins_off	0	0	4	3	6
4	1x59	opsins_off	33.3333	0	4	3	5
5	2x38	opsins_off	0	0	4	1	6
6	2x41	opsins_off	33.3333	0	4	2	5
7	2x57	opsins_off	33.3333	50	5	3	7
8	E1x51	opsins_off	66.6667	0	4	2	4
9	3x31	opsins_off	0	0	5	2	4
10	3x50	opsins_off	100	0	6	3	9
11	4x41	opsins_off	33.3333	0	4	3	5
12	5x42	opsins_off	66.6667	50	4	3	4
13	I3	opsins_off	66.6667	0	5	0	0
14	6x31	opsins_off	33.3333	0	5	1	4
15	7x39	opsins_off	100	0	4	2	5
16	7x42	opsins_off	100	0	4	2	7
17	8x47	opsins_off	0	0	4	2	8
18	8x49	opsins_off	0	0	4	1	6
19	8x54	opsins_off	0	0	4	3	6
20	CT	opsins_off	100	0	12	1	0
21	NT	Shared	100	100	12	9	0
22	1x60	Shared	66.6667	0	5	4	5
23	I1x50	Shared	66.6667	0	4	4	7
24	3x30	Shared	66.6667	0	4	4	6
25	3x37	Shared	66.6667	0	4	4	6
26	3x41	Shared	100	100	6	6	5
27	3x51	Shared	66.6667	100	4	4	7
28	I2x56	Shared	33.3333	50	4	4	7
29	4x50	Shared	66.6667	50	4	5	9
30	E2	Shared	100	100	29	29	0
31	5x39	Shared	100	100	5	4	6
32	5x461	Shared	100	100	6	5	6
33	6x44	Shared	0	50	4	4	9
34	6x48	Shared	66.6667	100	6	4	8
35	E3	Shared	100	100	6	7	0
36	7x53	Shared	100	100	4	5	9
37	8x50	Shared	0	100	4	4	8
38	Lig	Shared	100	100	10	6	0
39	1x38	opsins_on	0	50	1	4	4
40	1x50	opsins_on	0	50	3	4	9
41	2x42	opsins_on	0	50	3	4	7
42	2x45	opsins_on	66.6667	100	3	4	9
43	2x50	opsins_on	0	50	1	4	9
44	E1x50	opsins_on	66.6667	100	3	6	8
45	3x28	opsins_on	33.3333	0	3	4	5
46	3x42	opsins_on	33.3333	50	3	4	8
47	I2x50	opsins_on	0	0	2	4	8
48	4x56	opsins_on	33.3333	50	1	5	5
49	5x43	opsins_on	33.3333	0	1	4	5
50	5x46	opsins_on	0	0	2	4	4
51	5x58	opsins_on	0	50	3	4	9
52	6x30	opsins_on	0	50	1	5	7
53	6x51	opsins_on	33.3333	50	3	4	6
54	7x54	opsins_on	0	0	1	4	7

Orange: nodes, hubs and links specific of opsins_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of opsins_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	opsins_off Recurrence	opsins_on Recurrence	opsins_off Hub1?	opsins_on Hub1?	opsins_off Hub2?	opsins_on Hub2?	ConSurf1	ConSurf2
1	1x39	2x57	opsins_off	10.3455	0	Yes	No	Yes	No	7	7
2	1x39	7x39	opsins_off	18.7405	0	Yes	No	Yes	No	7	5
3	7x39	E2	opsins_off	27.7735	0	Yes	No	Yes	Yes	5	0
4	7x39	7x42	opsins_off	11.0775	0	Yes	No	Yes	No	5	7
5	E2	Lig	opsins_off	48.5422	0	Yes	Yes	Yes	Yes	0	0
6	1x39	2x61	opsins_off	10.1779	0.949832	Yes	No	No	No	7	6
7	1x43	2x57	opsins_off	11.6254	0	No	No	Yes	No	6	7
8	1x53	7x50	opsins_off	15.6001	0	No	No	No	No	9	9
9	1x53	8x50	opsins_off	18.0699	0	No	No	Yes	Yes	9	8
10	7x53	8x50	opsins_off	29.7076	0	Yes	Yes	Yes	Yes	9	8
11	2x43	7x53	opsins_off	44.1259	0	No	No	Yes	Yes	8	9
12	2x43	6x40	opsins_off	44.4858	0	No	No	No	No	8	8
13	6x40	7x49	opsins_off	45.0133	0	No	No	No	No	8	9
14	2x46	7x49	opsins_off	47.0742	0	No	No	No	No	9	9
15	3x42	4x49	opsins_off	96.0499	0	No	Yes	No	No	8	7
16	2x45	4x49	opsins_off	96.3116	1.44997	No	Yes	No	No	9	7
17	2x45	4x50	opsins_off	96.8105	8.71082	No	Yes	Yes	Yes	9	9
18	2x52	4x50	opsins_off	97.9145	2.92408	No	No	Yes	Yes	6	9
19	2x52	3x31	opsins_off	98.2989	0	No	No	Yes	No	6	4
20	3x30	3x31	opsins_off	99.5093	0	Yes	Yes	Yes	No	6	4
21	3x30	4x61	opsins_off	99.8283	1.21087	Yes	Yes	No	No	6	5
22	3x26	4x61	opsins_off	100	0	No	No	No	No	7	5
23	3x26	E2	opsins_off	99.9796	1.10558	No	No	Yes	Yes	7	0
24	1x56	8x50	opsins_off	10.047	0	No	No	Yes	Yes	7	8
25	2x40	I1x50	opsins_off	10.4396	0	No	No	Yes	Yes	8	7
26	2x40	7x53	opsins_off	14.1852	0	No	No	Yes	Yes	8	9
27	8x49	CT	opsins_off	11.8462	0	Yes	No	Yes	No	6	0
28	8x47	8x49	opsins_off	11.466	1.12751	Yes	No	Yes	No	8	6
29	7x53	8x47	opsins_off	17.9841	0	Yes	Yes	Yes	No	9	8
30	2x38	3x49	opsins_off	18.5933	0	Yes	No	No	No	6	8
31	3x49	3x50	opsins_off	27.0374	0	No	No	Yes	No	8	9
32	3x50	6x37	opsins_off	48.4809	0	Yes	No	No	No	9	8
33	3x46	6x37	opsins_off	48.898	0	No	No	No	No	9	8
34	2x37	2x38	opsins_off	15.6655	2.19799	No	No	Yes	No	7	6
35	2x37	2x40	opsins_off	15.6696	4.3938	No	No	No	No	7	8
36	3x37	Lig	opsins_off	21.4598	0	Yes	Yes	Yes	Yes	6	0
37	3x37	3x41	opsins_off	13.3919	0.0438722	Yes	Yes	Yes	Yes	6	5
38	3x41	5x461	opsins_off	11.0202	6.3834	Yes	Yes	Yes	Yes	5	6
39	5x42	5x461	opsins_off	13.576	0	Yes	No	Yes	Yes	4	6
40	5x42	E2	opsins_off	15.367	6.10042	Yes	No	Yes	Yes	4	0
41	3x41	5x50	opsins_off	10.2719	1.86676	Yes	Yes	No	No	5	9
42	3x50	6x34	opsins_off	41.6684	0	Yes	No	No	No	9	6
43	3x55	5x61	opsins_off	12.6723	2.32303	No	No	No	No	7	8
44	3x54	5x61	opsins_off	13.8949	1.16261	No	No	No	No	8	8
45	3x54	5x65	opsins_off	17.5138	0	No	No	No	No	8	8
46	5x65	6x34	opsins_off	40.6502	0	No	No	No	No	8	6
47	5x49	5x50	opsins_off	12.754	0.934477	No	No	No	No	5	9
48	5x69	6x35	opsins_off	10.3578	0	No	No	No	No	5	7
49	5x69	6x31	opsins_off	11.3964	0	No	No	Yes	No	5	4
50	5x65	6x31	opsins_off	24.3958	0	No	No	Yes	No	8	4
51	E2	E3	Shared	10.1084	12.7778	Yes	Yes	Yes	Yes	0	0
52	2x57	7x42	Shared	20.9364	18.2048	Yes	No	Yes	No	7	7
53	7x42	Lig	Shared	14.4919	19.069	Yes	No	Yes	Yes	7	0
54	2x46	3x42	Shared	47.843	28.9929	No	No	No	Yes	9	8
55	2x42	3x46	Shared	49.3601	14.9341	No	Yes	No	No	7	9
56	2x42	3x42	Shared	51.605	16.4937	No	Yes	No	Yes	7	8
57	6x48	Lig	Shared	15.9967	100	Yes	Yes	Yes	Yes	8	0
58	E2	NT	Shared	20.4907	36.585	Yes	Yes	Yes	Yes	0	0
59	1x38	1x42	opsins_on	2.91556	12.9269	No	Yes	No	No	4	7
60	1x42	2x57	opsins_on	5.82703	15.5856	No	No	Yes	No	7	7
61	E2x52	Lig	opsins_on	0	45.4779	No	No	Yes	Yes	4	0
62	E2	E2x52	opsins_on	1.25946	44.3372	Yes	Yes	No	No	0	4
63	6x51	Lig	opsins_on	1.36168	46.5988	No	Yes	Yes	Yes	6	0
64	6x51	E2	opsins_on	0.740135	44.9909	No	Yes	Yes	Yes	6	0
65	1x43	2x58	opsins_on	0	11.262	No	No	No	No	6	8
66	2x58	2x59	opsins_on	1.2799	13.5017	No	No	No	No	8	5
67	2x59	3x28	opsins_on	0	15.7369	No	No	No	Yes	5	5
68	3x28	E2x50	opsins_on	0	28.8218	No	Yes	No	No	5	9
69	E1x50	E2x50	opsins_on	0.0122674	30.8268	No	Yes	No	No	8	9
70	E1x50	NT	opsins_on	0	22.2278	No	Yes	Yes	Yes	8	0
71	1x50	2x50	opsins_on	1.34124	42.4858	No	Yes	No	Yes	9	9
72	2x50	7x49	opsins_on	0	47.6035	No	Yes	No	No	9	9
73	7x45	7x49	opsins_on	0	63.0969	No	No	No	No	9	9
74	6x47	7x45	opsins_on	0	63.3624	No	No	No	No	8	9
75	6x47	6x48	opsins_on	7.3073	65.2269	No	No	Yes	Yes	8	8
76	1x50	7x50	opsins_on	9.24146	34.7643	No	Yes	No	No	9	9
77	8x50	I1x50	opsins_on	0	20.576	Yes	Yes	Yes	Yes	8	7
78	7x54	8x50	opsins_on	0	26.5931	No	Yes	Yes	Yes	7	8
79	7x50	7x54	opsins_on	0	33.843	No	No	No	Yes	9	7
80	2x42	3x49	opsins_on	0	21.5237	No	Yes	No	No	7	8
81	2x46	2x50	opsins_on	0	25.0817	No	No	No	Yes	9	9
82	2x46	3x43	opsins_on	0	22.1532	No	No	No	No	9	8
83	3x43	7x49	opsins_on	0	32.2241	No	No	No	No	8	9
84	3x43	7x53	opsins_on	0	27.3477	No	No	Yes	Yes	8	9
85	3x50	5x58	opsins_on	0	16.8513	Yes	No	No	Yes	9	9
86	3x47	5x58	opsins_on	0	30.2433	No	No	No	Yes	9	9
87	3x47	5x54	opsins_on	0	34.2291	No	No	No	No	9	8
88	5x54	6x44	opsins_on	0	34.7226	No	No	Yes	Yes	8	9
89	6x44	6x48	opsins_on	4.87426	36.7429	Yes	Yes	Yes	Yes	9	8
90	3x49	I2x56	opsins_on	7.77346	14.3265	No	No	Yes	Yes	8	7
91	4x42	I2x56	opsins_on	0	10.1674	No	No	Yes	Yes	7	7
92	2x45	3x42	opsins_on	0	13.0278	No	Yes	No	Yes	9	8
93	2x64	E1x50	opsins_on	0	21.7628	No	No	No	Yes	5	8
94	3x47	5x57	opsins_on	1.30035	22.3814	No	No	No	No	9	8
95	3x51	5x57	opsins_on	2.59661	21.3394	Yes	Yes	No	No	7	8
96	5x58	6x37	opsins_on	0	17.8933	No	Yes	No	No	9	8
97	5x58	6x40	opsins_on	0	11.5186	No	Yes	No	No	9	8
98	6x30	6x34	opsins_on	0	14.5612	No	Yes	No	No	7	6
99	5x62	6x34	opsins_on	0	15.6755	No	No	No	No	5	6
100	5x62	6x37	opsins_on	0	16.7899	No	No	No	No	5	8
101	2x64	E2	opsins_on	1.12043	22.717	No	No	Yes	Yes	5	0
102	5x43	Lig	opsins_on	0	10.5776	No	Yes	Yes	Yes	5	0

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
E3	NT	opsins_off	21.6967	0	1	1	2	2
NT	NT	Shared	237.287	96.07	1	1	2	2
E2	NT	Shared	78.2267	45.84	1	1	1	2
1x32	NT	Shared	12.5767	9.1	1	1	2	2
1x32	E2	Shared	8.59667	8.61	1	1	2	1
1x35	2x64	opsins_off	5.00667	0	1	0	2	2
1x35	E2	Shared	4.94333	3.625	1	0	2	1
1x35	7x39	opsins_off	15.4233	0	1	0	2	2
2x57	7x42	Shared	8.27	5.77	0	0	2	1
2x60	3x28	Shared	11.29	4.115	0	0	2	1
2x64	E2	Shared	4.58667	3.18	1	1	2	1
E1x50	E2	opsins_off	4.33333	0	1	1	2	1
E1x50	E2x50	Shared	7.91667	4.19	1	1	2	2
3x26	E2	Shared	5.03667	5.355	1	0	2	1
3x28	7x42	opsins_off	8.55	0	1	0	1	1
3x28	Lig	opsins_off	4.91667	0	1	0	1	0
3x29	E2	Shared	5.31	6.52	0	0	2	1
3x32	Lig	Shared	6.04667	3.055	0	0	1	0
3x33	E2	Shared	5.82667	5.04	1	1	1	1
3x33	Lig	opsins_off	8.78	0	1	1	1	0
3x36	6x48	opsins_off	4.69	0	0	0	2	1
3x37	3x40	opsins_off	6.63	0	1	1	1	2
3x37	3x41	Shared	5.81333	4.99	1	1	1	2
3x37	5x461	Shared	7.39	9.63	1	1	1	2
3x37	Lig	opsins_off	5.41667	0	1	1	1	0
3x40	6x44	Shared	10.15	6.54	0	6	2	2
3x41	5x461	Shared	4.93667	5.535	1	1	2	2
4x56	5x461	Shared	13.2667	5.645	0	1	2	2
4x59	4x60	Shared	7.14	5.84	1	1	2	2
4x59	5x39	opsins_off	6.26	0	1	1	2	2
4x60	E2	Shared	13.9667	19.165	1	1	2	1
4x60	5x39	Shared	6.74	6.98	1	1	2	2
5x38	E2	Shared	4.94	5.56	1	0	2	1
5x39	E2	Shared	29.7167	17.575	1	1	2	1
5x42	E2	Shared	9.96667	5.565	1	1	2	1
E2	E2x52	Shared	15.7	3.81	1	1	1	1
E2	E2	Shared	138.603	102.615	1	1	1	1
5x36	E2	Shared	35.3233	18.415	0	0	2	1
E2	E2x51	Shared	7.39	4.865	1	1	1	2
E2	E2x50	opsins_off	6.09667	0	1	1	1	2
6x51	E2	Shared	16.6767	9.495	1	1	1	1
7x34	E2	Shared	17.84	5.82	1	0	2	1
7x35	E2	Shared	15.1833	4.145	0	1	2	1
7x39	E2	opsins_off	8.05	0	1	0	2	1
E2	Lig	opsins_off	4.83333	0	1	1	1	0
5x39	E2x52	Shared	4.18667	3.205	1	1	2	1
6x55	E2	Shared	8.89667	1.515	0	0	2	1
6x58	E2	opsins_off	12.09	0	1	0	2	1
E2	E3	Shared	9.39333	3.2	1	1	1	2
5x37	E2	opsins_off	7.56	0	1	0	2	1
5x37	E3	opsins_off	9.77	0	1	0	2	2
5x39	5x42	opsins_off	7.22333	0	1	1	2	2
5x42	5x461	opsins_off	11.6133	0	1	1	2	2
5x43	5x44	opsins_off	4.97333	0	0	1	1	2
5x47	5x51	opsins_off	4.87333	0	0	0	1	2
5x47	Lig	opsins_off	6.35333	0	0	0	1	0
6x44	6x48	Shared	16.37	5.475	0	6	2	1
6x48	7x41	opsins_off	6.48333	0	0	6	1	2
6x48	7x45	opsins_off	8.23667	0	0	6	1	2
6x48	Lig	Shared	14.0967	4.545	0	6	1	0
6x51	7x34	opsins_off	7.98333	0	1	1	1	2
6x51	Lig	Shared	21.77	18.32	1	1	1	0
6x54	7x34	opsins_off	6.59333	0	0	1	2	2
6x54	7x37	Shared	6.48	4.335	0	1	2	2
6x58	E3	Shared	8.37333	4.67	1	0	2	2
7x39	7x42	opsins_off	9.1	0	1	0	2	1
7x42	Lig	Shared	8.74333	8.435	1	0	1	0
6x47	6x48	Shared	3.48333	5.875	0	0	2	1
3x30	4x57	Shared	3.23333	5.13	0	1	2	2
7x38	E2	Shared	2.78333	2.22	0	0	2	1
5x35	5x38	opsins_off	2.48333	0	0	0	2	2
6x52	Lig	opsins_off	2.09333	0	0	0	1	0
4x63	E2	Shared	1.82	1.5	0	0	2	1
6x52	6x53	Shared	1.3	1.945	0	0	1	2
E1x50	NT	opsins_on	0	3.4	1	1	2	2
2x59	3x28	opsins_on	0	5.645	0	0	2	1
3x28	E2x50	opsins_on	0	4.565	1	0	1	2
3x30	E2	opsins_on	0	6.035	0	1	2	1
3x33	4x57	opsins_on	0	5.675	1	1	1	2
3x37	4x56	opsins_on	0	6.075	1	1	1	2
3x40	6x48	opsins_on	0	13.665	0	6	2	1
4x56	5x43	opsins_on	0	3.33	0	1	2	1
4x59	E2	opsins_on	0	5.4	1	1	2	1
E2x52	Lig	opsins_on	0	5.72	1	1	1	0
5x40	E2	opsins_on	0	5.2	0	0	2	1
6x54	E2	opsins_on	0	3.595	0	1	2	1
5x39	5x43	opsins_on	0	10.91	1	1	2	1
5x43	5x461	opsins_on	0	3.555	0	1	1	2
5x43	Lig	opsins_on	0	5.15	0	1	1	0
5x47	6x52	opsins_on	0	5.005	0	0	1	1
5x51	6x44	opsins_on	0	5.91	0	0	2	2
6x47	7x45	opsins_on	0	4.385	0	0	2	2
6x51	7x37	opsins_on	0	6.255	1	1	1	2
E3	E3	opsins_on	0	4.69	1	1	2	2
2x64	E1x50	opsins_on	0	6.04	1	1	2	2
2x65	E2	opsins_on	0	4.25	0	1	2	1
6x54	E3	opsins_on	0	3.75	0	1	2	2
5x35	E2	opsins_on	0	3.075	0	0	2	1
6x51	7x41	opsins_on	0	2.67	1	1	1	2
2x56	3x28	opsins_on	0	2.455	0	0	2	1
3x37	4x53	opsins_on	0	2.38	1	1	1	2
5x44	5x47	opsins_on	0	2.145	0	0	2	1
6x49	6x52	opsins_on	0	1.82	0	0	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	opsins_off	rhodopsin_off
	opsins_on	rhodopsin_on opsin1lw_on

Network Difference
Value	opsins_off	opsins_on
I_min	3.98667	3.075
Number of Linked Nodes	266	258
Number of Specific Nodes	11 (4.14%)	3 (1.16%)
Number of Shared Nodes	255 (95.86%)	255 (98.84%)
Number of Links	317	289
Number of Specific Links	173 (54.57%)	145 (50.17%)
Number of Shared Links	144 (45.43%)	144 (49.83%)
Number of Hubs	38	34
Number of Specific Hubs	20 (52.63%)	16 (47.06%)
Number of Shared Hubs	18 (47.37%)	18 (52.94%)
Average % Shared Neighbours (Jaccard)	35.51
Average % Shared Neighbours (Otsuka)	44.50
Average % Shared Neighbours (Overlap Coefficient)	53.04
Average % Shared Cliques (k3-6)	78.26
Graphlets Similarity	0.643227

Paths Difference
Value	opsins_off	opsins_on
Number Of Nodes in MetaPath	55	50
Specific Nodes in MetaPath	32 (58.18%)	27 (54.00%)
Shared Nodes in MetaPath	255 (95.86%)	255 (95.86%)
Number Of Links MetaPath	58	52
Specific Links in MetaPath	50 (86.21%)	44 (84.62%)
Shared Links in MetaPath	144 (45.43%)	144 (45.43%)
Number of Shortest Paths	47383	74924
Length Of Smallest Path	3	3
Average Path Length	14.6951	13.7255
Length of Longest Path	32	28
Minimum Path Strength	0.751667	0.6375
Average Path Strength	7.72581	6.36392
Maximum Path Strength	56.775	32.5025
Minimum Path Correlation	0.7	0.7
Average Path Correlation	0.935553	0.919972
Maximum Path Correlation	1	0.995
Minimum % Of Corr. Nodes	4.54545	5
Average % Of Corr. Nodes	57.6049	47.303
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	39.5057	44.7774
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

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