psnGPCR

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Orange: nodes, hubs and links specific of orexin_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of orexin_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	orexin_off Int. Strength	orexin_on Int. Strength	orexin_off Hub1?	orexin_on Hub1?	orexin_off Hub2?	orexin_on Hub2?	ConSurf1	ConSurf2
1	NT	NT	orexin_off	100	0	Yes	No	Yes	No	5	5
2	E2	NT	orexin_off	100	0	Yes	Yes	Yes	No	3	5
3	2x66	NT	orexin_off	100	0	No	No	Yes	No	5	5
4	1x31	NT	orexin_off	100	0	No	No	Yes	No	4	5
5	2x67	NT	orexin_off	100	0	No	No	Yes	No	4	5
6	1x35	1x39	orexin_off	100	0	No	No	Yes	Yes	5	7
7	1x39	2x60	orexin_off	100	0	Yes	Yes	No	No	7	7
8	1x43	2x54	orexin_off	100	0	No	No	No	No	6	7
9	1x49	7x50	orexin_off	100	0	No	No	No	No	8	9
10	1x53	7x53	orexin_off	100	0	No	No	Yes	Yes	9	9
11	8x49	I1x50	orexin_off	100	0	No	No	No	Yes	7	8
12	2x41	I1x51	orexin_off	100	0	No	No	No	No	4	8
13	2x38	3x49	orexin_off	100	0	No	No	No	No	6	9
14	2x39	3x50	orexin_off	100	0	No	No	No	No	8	9
15	2x40	8x50	orexin_off	100	0	No	No	Yes	Yes	9	8
16	2x42	3x42	orexin_off	100	0	Yes	Yes	No	No	8	7
17	2x42	4x46	orexin_off	100	0	Yes	Yes	No	No	8	8
18	2x43	7x53	orexin_off	100	0	No	No	Yes	Yes	8	9
19	2x61	2x65	orexin_off	100	0	No	No	No	No	6	5
20	2x62	E1x52	orexin_off	100	0	No	No	No	No	4	6
21	2x64	7x38	orexin_off	100	0	No	No	No	Yes	5	5
22	2x66	E1x51	orexin_off	100	0	No	No	No	No	5	4
23	3x28	E1x50	orexin_off	100	0	No	No	Yes	Yes	5	7
24	3x26	E2	orexin_off	100	0	No	No	Yes	Yes	6	3
25	3x32	7x42	orexin_off	100	0	Yes	No	Yes	Yes	7	7
26	3x36	6x48	orexin_off	100	0	No	No	Yes	Yes	6	7
27	3x38	4x49	orexin_off	100	0	Yes	No	No	No	7	6
28	3x43	6x44	orexin_off	100	0	No	No	Yes	No	9	9
29	3x44	5x54	orexin_off	100	0	No	No	No	No	7	8
30	3x46	6x37	orexin_off	100	0	No	No	Yes	No	8	8
31	3x48	3x52	orexin_off	100	0	No	No	Yes	No	6	4
32	3x49	3x50	orexin_off	100	0	No	No	No	No	9	9
33	3x50	3x53	orexin_off	100	0	No	No	No	No	9	8
34	3x52	3x56	orexin_off	100	0	Yes	No	Yes	No	4	6
35	3x52	I2x53	orexin_off	100	0	Yes	No	Yes	No	4	7
36	3x54	5x65	orexin_off	100	0	Yes	No	No	No	8	8
37	3x54	6x30	orexin_off	100	0	Yes	No	No	No	8	8
38	5x39	5x43	orexin_off	100	0	Yes	Yes	Yes	No	8	5
39	5x40	6x55	orexin_off	100	0	Yes	No	No	No	6	7
40	5x54	6x41	orexin_off	100	0	No	No	No	No	8	8
41	5x58	6x38	orexin_off	100	0	Yes	Yes	No	Yes	9	6
42	5x63	5x68	orexin_off	100	0	No	No	No	No	4	7
43	5x65	5x66	orexin_off	100	0	No	No	Yes	No	8	5
44	6x36	7x53	orexin_off	100	0	No	No	Yes	Yes	8	9
45	6x39	7x52	orexin_off	100	0	No	No	No	No	6	8
46	6x39	7x56	orexin_off	100	0	No	No	No	No	6	7
47	6x40	7x49	orexin_off	100	0	No	No	No	Yes	8	9
48	6x44	7x45	orexin_off	100	0	Yes	No	Yes	No	9	9
49	7x34	E3	orexin_off	100	0	Yes	No	Yes	Yes	4	3
50	7x34	7x38	orexin_off	100	0	Yes	No	No	Yes	4	5
51	7x39	7x40	orexin_off	100	0	Yes	Yes	No	No	5	8
52	7x49	7x53	orexin_off	100	0	No	Yes	Yes	Yes	9	9
53	7x53	8x50	orexin_off	100	0	Yes	Yes	Yes	Yes	9	8
54	7x54	8x51	orexin_off	100	0	No	No	No	No	7	8
55	7x54	8x54	orexin_off	100	0	No	No	No	Yes	7	7
56	8x50	8x54	orexin_off	100	0	Yes	Yes	No	Yes	8	7
57	8x61	8x62	orexin_off	100	0	No	No	No	No	3	1
58	3x56	I2x53	orexin_off	100	0	Yes	No	Yes	No	6	7
59	I2x51	I2x53	orexin_off	100	0	No	No	Yes	No	7	7
60	7x54	7x55	orexin_off	100	0	No	No	No	No	7	5
61	5x69	6x27	orexin_off	100	0	No	No	No	No	5	4
62	6x23	I3	orexin_off	100	0	No	No	No	No	0	0
63	3x47	5x54	orexin_off	75	0	No	No	No	No	8	8
64	2x551	3x31	orexin_off	50	0	Yes	No	No	No	5	5
65	2x53	3x32	orexin_off	70.8333	0	No	No	Yes	No	7	7
66	1x36	2x65	orexin_off	62.5	0	No	No	No	No	5	5
67	3x25	E2	orexin_off	50	0	No	No	Yes	Yes	9	3
68	1x54	1x58	orexin_off	62.5	0	No	No	No	No	6	3
69	1x56	8x53	orexin_off	29.1667	0	No	No	Yes	No	8	7
70	2x59	E1x52	orexin_off	50	0	No	No	No	No	4	6
71	2x39	6x37	orexin_off	62.5	0	No	No	Yes	No	8	8
72	1x45	7x47	orexin_off	29.1667	0	No	No	No	No	5	5
73	3x34	4x57	orexin_off	25	0	No	No	Yes	No	5	7
74	3x37	4x56	orexin_off	45.8333	0	No	No	No	No	7	5
75	6x35	7x56	orexin_off	50	0	No	No	No	No	8	7
76	3x54	5x64	orexin_off	12.5	0	Yes	No	No	No	8	5
77	3x27	3x31	orexin_off	4.16667	0	No	No	No	No	4	5
78	2x38	4x42	orexin_off	25	0	No	No	No	No	6	7
79	2x52	2x551	orexin_off	54.1667	0	No	No	Yes	No	6	5
80	6x53	6x57	orexin_off	4.16667	0	No	No	No	No	5	5
81	1x52	8x57	orexin_off	25	0	Yes	No	No	No	6	6
82	1x59	8x53	orexin_off	50	0	No	No	Yes	No	6	7
83	4x41	I2x53	orexin_off	50	0	No	No	Yes	No	7	7
84	1x55	1x59	orexin_off	58.3333	0	No	No	No	No	5	6
85	8x60	CT	orexin_off	50	0	No	No	No	No	9	0
86	2x41	4x39	orexin_off	37.5	0	No	No	No	No	4	3
87	1x52	8x58	orexin_off	20.8333	0	Yes	No	No	No	6	5
88	2x46	3x39	orexin_off	12.5	0	No	Yes	No	No	9	9
89	1x57	2x40	orexin_off	8.33333	0	No	No	No	No	7	9
90	2x63	E1x50	orexin_off	0	0	No	No	Yes	Yes	5	7
91	1x54	2x44	orexin_off	8.33333	0	No	No	No	No	6	6
92	2x41	4x43	orexin_off	50	0	No	No	No	No	4	4
93	2x55	2x551	orexin_off	0	0	No	No	Yes	No	4	5
94	1x42	7x47	orexin_off	12.5	0	No	No	No	No	7	5
95	5x66	6x34	orexin_off	0	0	Yes	No	No	No	5	7
96	8x59	CT	orexin_off	50	0	No	No	No	No	4	0
97	1x44	1x48	orexin_off	0	0	No	No	No	No	4	4
98	8x51	8x55	orexin_off	20.8333	0	No	No	No	No	8	5
99	5x63	5x67	orexin_off	12.5	0	No	No	No	No	4	5
100	6x28	6x32	orexin_off	20.8333	0	No	No	No	No	5	8
101	1x33	1x37	orexin_off	29.1667	0	No	No	No	No	4	4
102	6x54	7x33	orexin_off	0	0	No	No	No	No	5	5
103	3x52	I2x52	orexin_off	8.33333	0	Yes	No	No	No	4	5
104	6x20	6x23	orexin_off	12.5	0	No	No	No	No	0	0
105	6x43	7x48	orexin_off	0	0	No	No	No	No	6	6
106	1x51	1x55	orexin_off	0	0	No	No	No	No	4	5
107	8x63	CT	orexin_off	25	0	No	No	No	No	0	0
108	5x70	5x71	orexin_off	20.8333	0	No	No	No	No	0	0
109	1x31	7x32	orexin_off	25	0	No	No	No	No	4	1
110	8x60	8x61	orexin_off	8.33333	0	No	No	No	No	9	3
111	4x59	4x63	orexin_off	0	0	No	No	No	No	5	5
112	5x46	5x461	orexin_off	0	0	No	No	No	No	4	6
113	5x51	5x55	orexin_off	0	0	No	No	No	No	6	5
114	6x24	6x28	orexin_off	4.16667	0	No	No	No	No	0	5
115	7x45	Na1	orexin_off	12.5	0	Yes	No	No	No	9	0
116	5x71	6x23	orexin_off	12.5	0	No	No	No	No	0	0
117	8x58	8x62	orexin_off	12.5	0	No	No	No	No	5	1
118	4x48	4x51	orexin_off	0	0	No	No	No	No	3	3
119	5x53	5x57	orexin_off	12.5	0	No	No	No	No	7	5
120	5x52	5x55	orexin_off	0	0	No	No	No	No	4	5
121	5x38	5x42	orexin_off	0	0	No	No	No	No	4	4
122	5x35	5x38	orexin_off	0	0	No	No	No	No	3	4
123	7x28	7x31	orexin_off	8.33333	0	No	No	No	No	1	3
124	6x24	I3	orexin_off	8.33333	0	No	No	No	No	0	0
125	8x53	8x56	orexin_off	0	0	Yes	No	No	No	7	4
126	1x41	1x45	orexin_off	0	0	No	No	No	No	3	5
127	5x53	5x56	orexin_off	0	0	No	No	No	No	7	4
128	5x71	5x72	orexin_off	0	0	No	No	No	No	0	0
129	6x20	6x22	orexin_off	0	0	No	No	No	No	0	0
130	6x21	6x25	orexin_off	0	0	No	No	No	No	0	3
131	1x32	NT	Shared	100	33.3333	No	No	Yes	No	7	5
132	1x33	1x34	Shared	100	0	No	No	No	No	4	6
133	1x38	7x39	Shared	100	0	No	No	Yes	Yes	4	5
134	1x39	2x57	Shared	100	100	Yes	Yes	Yes	Yes	7	7
135	1x39	2x61	Shared	100	100	Yes	Yes	No	No	7	6
136	1x39	7x39	Shared	100	100	Yes	Yes	Yes	Yes	7	5
137	1x39	7x42	Shared	100	100	Yes	Yes	Yes	Yes	7	7
138	1x42	7x39	Shared	100	100	No	No	Yes	Yes	7	5
139	1x43	1x47	Shared	100	100	No	No	No	No	6	6
140	1x43	2x57	Shared	100	100	No	No	Yes	Yes	6	7
141	1x46	2x54	Shared	100	100	No	No	No	No	8	7
142	1x50	2x47	Shared	100	100	Yes	Yes	No	No	9	9
143	1x50	2x50	Shared	100	100	Yes	Yes	No	Yes	9	9
144	1x50	7x50	Shared	100	100	Yes	Yes	No	No	9	9
145	1x53	2x47	Shared	100	100	No	No	No	No	9	9
146	1x57	2x44	Shared	100	100	No	No	No	No	7	6
147	1x60	I1x49	Shared	100	100	No	Yes	No	No	6	5
148	1x60	I1x50	Shared	100	100	No	Yes	No	Yes	6	8
149	1x60	8x53	Shared	100	100	No	Yes	Yes	No	6	7
150	I1x48	I1x51	Shared	100	100	No	No	No	No	7	8
151	8x50	I1x50	Shared	100	100	Yes	Yes	No	Yes	8	8
152	2x37	2x40	Shared	100	100	No	No	No	No	7	9
153	2x42	3x45	Shared	100	100	Yes	Yes	No	No	8	6
154	2x42	3x46	Shared	100	100	Yes	Yes	No	No	8	8
155	2x42	4x45	Shared	100	100	Yes	Yes	No	No	8	6
156	2x45	3x42	Shared	100	100	No	No	No	No	9	7
157	2x45	4x46	Shared	100	100	No	No	No	No	9	8
158	2x45	4x50	Shared	100	100	No	No	No	No	9	9
159	2x46	3x43	Shared	100	100	No	Yes	No	No	9	9
160	2x50	7x46	Shared	100	100	No	Yes	No	No	9	9
161	2x53	3x35	Shared	100	100	No	No	No	No	7	5
162	2x56	3x32	Shared	100	100	No	Yes	Yes	No	7	7
163	2x56	7x42	Shared	100	100	No	Yes	Yes	Yes	7	7
164	2x57	2x58	Shared	100	33.3333	Yes	Yes	No	No	7	8
165	2x57	7x42	Shared	100	100	Yes	Yes	Yes	Yes	7	7
166	2x60	7x42	Shared	100	100	No	No	Yes	Yes	7	7
167	2x60	Lig	Shared	100	100	No	No	Yes	Yes	7	0
168	2x64	7x35	Shared	100	100	No	No	No	No	5	4
169	2x66	E1x49	Shared	100	100	No	No	No	No	5	5
170	2x67	7x31	Shared	100	100	No	No	No	No	4	3
171	E1x49	E1x51	Shared	100	100	No	No	No	No	5	4
172	E1x50	E1x52	Shared	100	100	Yes	Yes	No	No	7	6
173	3x25	E1x50	Shared	100	100	No	No	Yes	Yes	9	7
174	E1x50	E2x50	Shared	100	100	Yes	Yes	No	No	7	9
175	3x22	E2	Shared	100	100	No	No	Yes	Yes	4	3
176	3x24	3x28	Shared	100	33.3333	No	Yes	No	No	5	5
177	3x25	E2x50	Shared	100	100	No	No	No	No	9	9
178	3x29	4x65	Shared	100	100	No	No	No	No	5	6
179	3x29	Lig	Shared	100	100	No	No	Yes	Yes	5	0
180	3x30	3x34	Shared	100	100	No	Yes	No	No	6	5
181	3x30	4x54	Shared	100	100	No	Yes	No	No	6	4
182	3x30	4x62	Shared	100	100	No	Yes	No	No	6	6
183	3x32	Lig	Shared	100	100	Yes	No	Yes	Yes	7	0
184	3x33	4x57	Shared	100	100	No	No	Yes	No	6	7
185	3x33	4x61	Shared	100	100	No	No	Yes	Yes	6	6
186	3x36	Lig	Shared	100	100	No	No	Yes	Yes	6	0
187	3x37	4x53	Shared	100	100	No	No	No	No	7	8
188	3x38	4x50	Shared	100	100	Yes	No	No	No	7	9
189	3x38	4x53	Shared	100	100	Yes	No	No	No	7	8
190	3x40	5x50	Shared	100	100	No	No	No	No	8	9
191	3x40	6x44	Shared	100	100	No	No	Yes	No	8	9
192	3x41	4x49	Shared	100	33.3333	No	No	No	No	6	6
193	3x45	4x49	Shared	100	100	No	No	No	No	6	6
194	3x47	5x58	Shared	100	100	No	No	Yes	Yes	8	9
195	3x51	3x52	Shared	100	100	Yes	Yes	Yes	No	8	4
196	3x51	3x55	Shared	100	100	Yes	Yes	No	No	8	7
197	3x51	3x56	Shared	100	100	Yes	Yes	Yes	No	8	6
198	3x51	5x57	Shared	100	100	Yes	Yes	No	No	8	5
199	3x51	5x60	Shared	100	100	Yes	Yes	No	No	8	5
200	3x56	I2x50	Shared	100	0	Yes	No	No	No	6	9
201	4x38	4x41	Shared	100	0	No	No	No	No	5	7
202	4x56	4x57	Shared	100	100	No	No	Yes	No	5	7
203	4x57	5x43	Shared	100	100	Yes	No	Yes	No	7	5
204	4x60	5x39	Shared	100	100	No	No	Yes	Yes	6	8
205	4x61	E2x52	Shared	100	100	Yes	Yes	Yes	Yes	6	4
206	4x61	5x39	Shared	100	100	Yes	Yes	Yes	Yes	6	8
207	4x61	Lig	Shared	100	100	Yes	Yes	Yes	Yes	6	0
208	4x64	E2x52	Shared	100	100	No	No	Yes	Yes	6	4
209	4x64	E2	Shared	100	100	No	No	Yes	Yes	6	3
210	E2	E2	Shared	100	100	Yes	Yes	Yes	Yes	3	3
211	6x59	E2x51	Shared	100	100	Yes	Yes	No	No	4	5
212	E2	E2x52	Shared	100	100	Yes	Yes	Yes	Yes	3	4
213	5x40	E2x52	Shared	100	100	Yes	No	Yes	Yes	6	4
214	6x59	E2x52	Shared	100	100	Yes	Yes	Yes	Yes	4	4
215	5x35	E2	Shared	100	33.3333	No	No	Yes	Yes	3	3
216	5x36	E2	Shared	100	100	No	No	Yes	Yes	5	3
217	5x39	E2	Shared	100	100	Yes	Yes	Yes	Yes	8	3
218	5x34	5x38	Shared	100	0	No	No	No	No	4	4
219	5x39	5x40	Shared	100	100	Yes	Yes	Yes	No	8	6
220	5x40	6x59	Shared	100	100	Yes	No	Yes	Yes	6	4
221	5x41	6x60	Shared	100	0	No	No	Yes	Yes	5	5
222	5x43	5x461	Shared	100	100	Yes	No	No	No	5	6
223	5x43	Lig	Shared	100	100	Yes	No	Yes	Yes	5	0
224	5x44	5x47	Shared	100	100	No	Yes	Yes	Yes	6	8
225	5x44	5x48	Shared	100	33.3333	No	Yes	No	No	6	5
226	5x44	6x56	Shared	100	100	No	Yes	No	No	6	6
227	5x47	5x51	Shared	100	100	Yes	Yes	No	No	8	6
228	5x47	6x49	Shared	100	100	Yes	Yes	No	No	8	6
229	5x47	6x52	Shared	100	100	Yes	Yes	No	No	8	6
230	5x58	6x37	Shared	100	100	Yes	Yes	Yes	No	9	8
231	5x62	5x66	Shared	100	100	No	No	Yes	No	6	5
232	5x66	6x31	Shared	100	100	Yes	No	No	No	5	5
233	6x27	6x31	Shared	100	33.3333	No	No	No	No	4	5
234	6x36	7x56	Shared	100	33.3333	No	No	No	No	8	7
235	6x40	7x52	Shared	100	100	No	No	No	No	8	8
236	6x42	6x46	Shared	100	0	No	No	No	No	4	5
237	6x43	7x52	Shared	100	100	No	No	No	No	6	8
238	6x44	6x48	Shared	100	100	Yes	No	Yes	Yes	9	7
239	6x47	7x45	Shared	100	100	No	No	Yes	No	8	9
240	6x48	7x41	Shared	100	100	Yes	Yes	No	No	7	7
241	6x48	7x45	Shared	100	100	Yes	Yes	Yes	No	7	9
242	6x51	7x37	Shared	100	100	No	Yes	No	No	7	6
243	6x51	Lig	Shared	100	100	No	Yes	Yes	Yes	7	0
244	6x54	7x34	Shared	100	100	No	No	Yes	No	5	4
245	6x55	Lig	Shared	100	100	No	No	Yes	Yes	7	0
246	6x56	6x60	Shared	100	0	No	No	Yes	Yes	6	5
247	6x57	E3	Shared	100	100	No	No	Yes	Yes	5	3
248	6x58	6x59	Shared	100	100	No	No	Yes	Yes	3	4
249	6x58	E3	Shared	100	100	No	No	Yes	Yes	3	3
250	6x58	7x34	Shared	100	100	No	No	Yes	No	3	4
251	6x60	6x61	Shared	100	100	Yes	Yes	No	No	5	3
252	E3	E3	Shared	100	100	Yes	Yes	Yes	Yes	3	3
253	7x30	E3	Shared	100	100	No	No	Yes	Yes	5	3
254	7x26	7x29	Shared	100	100	No	No	No	No	3	4
255	7x27	7x31	Shared	100	100	No	No	No	No	1	3
256	7x36	7x40	Shared	100	100	No	No	No	No	4	8
257	7x38	Lig	Shared	100	100	No	Yes	Yes	Yes	5	0
258	7x39	7x43	Shared	100	33.3333	Yes	Yes	No	No	5	4
259	7x45	7x49	Shared	100	100	Yes	No	No	Yes	9	9
260	8x47	8x50	Shared	100	33.3333	No	No	Yes	Yes	8	8
261	8x48	8x51	Shared	100	33.3333	No	No	No	No	5	8
262	3x49	I2	Shared	100	100	No	No	No	Yes	9	5
263	5x59	5x63	Shared	100	0	No	No	No	No	2	4
264	6x26	6x30	Shared	100	100	No	No	No	No	4	8
265	3x54	5x61	Shared	50	100	Yes	No	No	No	8	9
266	1x52	8x54	Shared	75	0	Yes	No	No	Yes	6	7
267	6x49	6x50	Shared	41.6667	100	No	No	No	No	6	9
268	2x551	2x56	Shared	50	0	Yes	No	No	Yes	5	7
269	5x64	5x68	Shared	58.3333	33.3333	No	No	No	No	5	7
270	7x26	E3	Shared	50	33.3333	No	No	Yes	Yes	3	3
271	6x50	7x40	Shared	41.6667	100	No	No	No	No	9	8
272	4x59	4x60	Shared	33.3333	100	No	No	No	No	5	6
273	5x58	5x61	Shared	25	0	Yes	Yes	No	No	9	9
274	2x49	3x38	Shared	16.6667	66.6667	No	No	Yes	No	8	7
275	7x51	7x55	Shared	20.8333	33.3333	No	No	No	No	6	5
276	5x51	6x45	Shared	4.16667	33.3333	No	No	No	No	6	5
277	4x41	I2	Shared	29.1667	100	No	No	No	Yes	7	5
278	5x45	5x48	Shared	29.1667	0	No	No	No	No	4	5
279	6x33	6x37	Shared	0	0	No	No	Yes	No	8	8
280	4x52	4x56	Shared	12.5	0	No	No	No	No	5	5
281	1x48	1x52	Shared	4.16667	33.3333	No	No	Yes	No	4	6
282	3x21	E1x50	Shared	0	0	No	No	Yes	Yes	8	7
283	1x54	2x48	Shared	12.5	0	No	No	No	No	6	5
284	1x58	I1x51	Shared	25	0	No	No	No	No	3	8
285	1x50	2x51	Shared	4.16667	100	Yes	Yes	No	No	9	7
286	6x25	6x28	Shared	50	33.3333	No	No	No	No	3	5
287	5x49	5x50	Shared	8.33333	0	No	No	No	No	5	9
288	1x36	1x40	Shared	0	0	No	No	No	No	5	3
289	4x38	4x40	Shared	20.8333	100	No	No	No	No	5	5
290	4x47	4x51	Shared	0	0	No	No	No	No	3	3
291	8x52	8x55	Shared	12.5	33.3333	No	No	No	No	5	5
292	4x43	4x44	Shared	12.5	100	No	No	No	No	4	3
293	1x37	1x38	Shared	0	0	No	No	No	No	4	4
294	6x32	6x35	Shared	12.5	100	No	No	No	No	8	8
295	4x51	4x55	Shared	0	0	No	No	No	No	3	3
296	5x37	6x60	Shared	8.33333	100	No	No	Yes	Yes	4	5
297	4x48	4x52	Shared	0	0	No	No	No	No	3	5
298	6x38	6x42	Shared	4.16667	0	No	Yes	No	No	6	4
299	1x35	7x35	orexin_on	0	100	No	No	No	No	5	4
300	1x53	7x54	orexin_on	0	100	No	No	No	No	9	7
301	1x58	1x59	orexin_on	0	100	No	No	No	No	3	6
302	8x53	I1x50	orexin_on	0	100	Yes	No	No	Yes	7	8
303	2x43	7x54	orexin_on	0	100	No	No	No	No	8	7
304	2x46	2x50	orexin_on	0	100	No	Yes	No	Yes	9	9
305	2x46	3x42	orexin_on	0	100	No	Yes	No	No	9	7
306	2x46	7x49	orexin_on	0	100	No	Yes	No	Yes	9	9
307	2x50	7x49	orexin_on	0	100	No	Yes	No	Yes	9	9
308	2x52	3x35	orexin_on	0	100	No	No	No	No	6	5
309	2x53	7x46	orexin_on	0	100	No	No	No	No	7	9
310	2x60	7x38	orexin_on	0	100	No	No	No	Yes	7	5
311	2x63	Lig	orexin_on	0	100	No	No	Yes	Yes	5	0
312	E1x49	E2	orexin_on	0	100	No	No	Yes	Yes	5	3
313	3x24	E1x52	orexin_on	0	100	No	Yes	No	No	5	6
314	3x28	3x29	orexin_on	0	100	No	No	No	No	5	5
315	3x30	4x59	orexin_on	0	100	No	Yes	No	No	6	5
316	3x33	Lig	orexin_on	0	100	No	No	Yes	Yes	6	0
317	3x40	6x48	orexin_on	0	100	No	No	Yes	Yes	8	7
318	3x43	7x49	orexin_on	0	100	No	No	No	Yes	9	9
319	3x43	7x53	orexin_on	0	100	No	No	Yes	Yes	9	9
320	3x44	5x53	orexin_on	0	100	No	No	No	No	7	7
321	3x46	3x50	orexin_on	0	100	No	No	No	No	8	9
322	3x46	7x53	orexin_on	0	100	No	No	Yes	Yes	8	9
323	3x50	5x58	orexin_on	0	100	No	No	Yes	Yes	9	9
324	3x50	7x53	orexin_on	0	100	No	No	Yes	Yes	9	9
325	3x52	I2	orexin_on	0	100	Yes	No	No	Yes	4	5
326	3x52	4x41	orexin_on	0	100	Yes	No	No	No	4	7
327	3x56	I2x52	orexin_on	0	100	Yes	No	No	No	6	5
328	I2	I2x52	orexin_on	0	100	No	Yes	No	No	5	5
329	4x65	E2x52	orexin_on	0	100	No	No	Yes	Yes	6	4
330	5x44	6x52	orexin_on	0	100	No	Yes	No	No	6	6
331	5x54	5x58	orexin_on	0	100	No	No	Yes	Yes	8	9
332	5x54	6x44	orexin_on	0	100	No	No	Yes	No	8	9
333	5x55	6x41	orexin_on	0	100	No	No	No	No	5	8
334	5x58	6x41	orexin_on	0	100	Yes	Yes	No	No	9	8
335	5x62	6x38	orexin_on	0	100	No	No	No	Yes	6	6
336	5x65	6x33	orexin_on	0	100	No	No	No	No	8	8
337	6x40	7x53	orexin_on	0	100	No	No	Yes	Yes	8	9
338	6x51	7x38	orexin_on	0	100	No	Yes	No	Yes	7	5
339	6x51	7x41	orexin_on	0	100	No	Yes	No	No	7	7
340	7x30	7x34	orexin_on	0	100	No	No	Yes	No	5	4
341	7x31	Lig	orexin_on	0	100	No	No	Yes	Yes	3	0
342	7x36	7x39	orexin_on	0	100	No	No	Yes	Yes	4	5
343	7x38	7x42	orexin_on	0	100	No	Yes	Yes	Yes	5	7
344	7x41	7x42	orexin_on	0	100	No	No	Yes	Yes	7	7
345	7x52	7x53	orexin_on	0	100	No	No	Yes	Yes	8	9
346	7x54	8x50	orexin_on	0	100	No	No	Yes	Yes	7	8
347	7x55	8x50	orexin_on	0	100	No	No	Yes	Yes	5	8
348	8x49	8x53	orexin_on	0	100	No	No	Yes	No	7	7
349	2x53	2x56	orexin_on	0	100	No	No	No	Yes	7	7
350	4x40	4x44	orexin_on	0	100	No	No	No	No	5	3
351	E3	Lig	orexin_on	0	100	Yes	Yes	Yes	Yes	3	0
352	7x27	Lig	orexin_on	0	100	No	No	Yes	Yes	1	0
353	1x39	7x35	orexin_on	0	66.6667	Yes	Yes	No	No	7	4
354	2x40	2x43	orexin_on	0	33.3333	No	No	No	No	9	8
355	5x65	6x30	orexin_on	0	66.6667	No	No	No	No	8	8
356	2x42	4x42	orexin_on	0	33.3333	Yes	Yes	No	No	8	7
357	5x62	6x34	orexin_on	0	33.3333	No	No	No	No	6	7
358	2x38	I2	orexin_on	0	66.6667	No	No	No	Yes	6	5
359	2x65	2x66	orexin_on	0	33.3333	No	No	No	No	5	5
360	3x44	5x50	orexin_on	0	66.6667	No	No	No	No	7	9
361	1x47	2x54	orexin_on	0	0	No	No	No	No	6	7
362	7x55	8x54	orexin_on	0	33.3333	No	No	No	Yes	5	7
363	7x28	7x29	orexin_on	0	66.6667	No	No	No	No	1	4
364	3x48	5x53	orexin_on	0	33.3333	No	No	No	No	6	7
365	I2x50	I2x51	orexin_on	0	66.6667	No	No	No	No	9	7
366	3x22	3x26	orexin_on	0	66.6667	No	No	No	No	4	6
367	2x41	4x42	orexin_on	0	33.3333	No	No	No	No	4	7
368	2x37	2x39	orexin_on	0	33.3333	No	No	No	No	7	8
369	1x60	8x57	orexin_on	0	0	No	Yes	No	No	6	6
370	4x63	4x64	orexin_on	0	0	No	No	No	No	5	6
371	2x42	3x49	orexin_on	0	33.3333	Yes	Yes	No	No	8	9
372	1x47	2x55	orexin_on	0	33.3333	No	No	No	No	6	4
373	1x36	2x61	orexin_on	0	33.3333	No	No	No	No	5	6
374	6x49	6x53	orexin_on	0	0	No	No	No	No	6	5
375	6x38	6x41	orexin_on	0	0	No	Yes	No	No	6	8
376	1x56	8x54	orexin_on	0	0	No	No	No	Yes	8	7
377	1x54	2x47	orexin_on	0	0	No	No	No	No	6	9
378	1x33	1x35	orexin_on	0	33.3333	No	No	No	No	4	5
379	2x38	4x39	orexin_on	0	33.3333	No	No	No	No	6	3
380	5x48	5x52	orexin_on	0	66.6667	No	No	No	No	5	4
381	2x62	2x66	orexin_on	0	33.3333	No	No	No	No	4	5
382	2x59	3x32	orexin_on	0	0	No	No	Yes	No	4	7
383	2x50	3x39	orexin_on	0	33.3333	No	Yes	No	No	9	9
384	6x32	6x36	orexin_on	0	33.3333	No	No	No	No	8	8
385	5x37	5x38	orexin_on	0	33.3333	No	No	No	No	4	4
386	5x67	5x68	orexin_on	0	33.3333	No	No	No	No	5	7
387	1x33	NT	orexin_on	0	33.3333	No	No	Yes	No	4	5
388	1x46	7x47	orexin_on	0	0	No	No	No	No	8	5
389	8x54	8x58	orexin_on	0	33.3333	No	Yes	No	No	7	5
390	1x38	1x41	orexin_on	0	33.3333	No	No	No	No	4	3
391	1x48	1x49	orexin_on	0	0	No	No	No	No	4	8
392	5x68	5x70	orexin_on	0	33.3333	No	No	No	No	7	0
393	3x55	5x64	orexin_on	0	0	No	No	No	No	7	5
394	7x29	7x33	orexin_on	0	0	No	No	No	No	4	5
395	1x59	8x57	orexin_on	0	33.3333	No	No	No	No	6	6
396	1x31	1x32	orexin_on	0	33.3333	No	No	No	No	4	7
397	3x24	3x27	orexin_on	0	0	No	Yes	No	No	5	4
398	7x51	7x56	orexin_on	0	0	No	No	No	No	6	7
399	3x30	3x31	orexin_on	0	0	No	Yes	No	No	6	5
400	7x48	7x51	orexin_on	0	0	No	No	No	No	6	6
401	6x25	6x29	orexin_on	0	0	No	No	No	No	3	6
402	1x44	1x45	orexin_on	0	0	No	No	No	No	4	5
403	1x51	2x51	orexin_on	0	0	No	No	No	No	4	7
404	6x39	6x43	orexin_on	0	0	No	No	No	No	6	6
405	5x52	5x56	orexin_on	0	0	No	No	No	No	4	4
406	1x60	8x56	orexin_on	0	0	No	Yes	No	No	6	4
407	4x56	5x46	orexin_on	0	0	No	No	No	No	5	4
408	1x57	I1x50	orexin_on	0	0	No	No	No	Yes	7	8
409	3x23	3x24	orexin_on	0	0	No	No	No	Yes	3	5
410	5x59	6x38	orexin_on	0	0	No	No	No	Yes	2	6
411	1x43	1x44	orexin_on	0	0	No	No	No	No	6	4
412	1x55	8x58	orexin_on	0	0	No	No	No	No	5	5
413	6x28	6x31	orexin_on	0	0	No	No	No	No	5	5
414	6x23	6x27	orexin_on	0	0	No	No	No	No	0	4
415	6x23	6x24	orexin_on	0	0	No	No	No	No	0	0
416	5x39	5x42	orexin_on	0	0	Yes	Yes	No	No	8	4
417	4x43	4x47	orexin_on	0	0	No	No	No	No	4	3
418	8x54	8x55	orexin_on	0	0	No	Yes	No	No	7	5

Orange: nodes, hubs and links specific of orexin_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of orexin_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	orexin_off Avg Int. Strength	orexin_on Avg Int. Strength	orexin_off Num Of Links	orexin_on Num Of Links	ConSurf
1	NT	orexin_off	50	0	7	2	5
2	1x52	orexin_off	0	0	4	2	6
3	2x551	orexin_off	0	0	4	1	5
4	3x32	orexin_off	25	0	4	3	7
5	3x38	orexin_off	41.6667	33.3333	4	3	7
6	3x52	orexin_off	0	0	5	3	4
7	3x54	orexin_off	0	0	4	1	8
8	3x56	orexin_off	50	0	4	3	6
9	I2x53	orexin_off	0	0	4	0	7
10	4x57	orexin_off	0	33.3333	4	3	7
11	5x40	orexin_off	25	0	4	3	6
12	5x43	orexin_off	79.1667	0	4	3	5
13	5x66	orexin_off	12.5	0	4	2	5
14	6x37	orexin_off	0	0	4	2	8
15	6x44	orexin_off	50	100	4	3	9
16	7x34	orexin_off	37.5	33.3333	4	3	4
17	7x45	orexin_off	29.1667	0	5	3	9
18	8x53	orexin_off	0	0	4	3	7
19	1x39	Shared	100	66.6667	6	5	7
20	1x50	Shared	0	33.3333	4	4	9
21	2x42	Shared	83.3333	66.6667	5	5	8
22	2x57	Shared	95.8333	33.3333	4	4	7
23	E1x50	Shared	100	66.6667	6	4	7
24	3x51	Shared	100	100	5	5	8
25	4x61	Shared	50	33.3333	4	4	6
26	E2	Shared	100	100	11	9	3
27	E2x52	Shared	100	100	5	6	4
28	5x39	Shared	83.3333	33.3333	5	5	8
29	5x47	Shared	70.8333	66.6667	4	4	8
30	5x58	Shared	0	100	4	6	9
31	6x48	Shared	62.5	66.6667	4	4	7
32	6x59	Shared	91.6667	33.3333	4	4	4
33	6x60	Shared	0	0	4	4	5
34	E3	Shared	100	100	7	7	3
35	7x39	Shared	75	0	5	5	5
36	7x42	Shared	100	100	5	6	7
37	7x53	Shared	62.5	100	5	5	9
38	8x50	Shared	100	33.3333	5	4	8
39	Lig	Shared	100	100	9	14	0
40	1x60	orexin_on	0	0	3	5	6
41	I1x50	orexin_on	29.1667	33.3333	3	4	8
42	2x46	orexin_on	0	33.3333	2	4	9
43	2x50	orexin_on	41.6667	66.6667	2	5	9
44	2x56	orexin_on	25	0	3	4	7
45	3x24	orexin_on	0	0	1	4	5
46	3x30	orexin_on	0	0	3	5	6
47	I2	orexin_on	0	66.6667	2	5	5
48	5x44	orexin_on	12.5	33.3333	3	4	6
49	6x38	orexin_on	0	0	2	4	6
50	6x51	orexin_on	0	33.3333	2	4	7
51	7x38	orexin_on	70.8333	66.6667	3	4	5
52	7x49	orexin_on	37.5	33.3333	3	4	9
53	8x54	orexin_on	0	0	3	5	7

Orange: nodes, hubs and links specific of orexin_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of orexin_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	orexin_off Recurrence	orexin_on Recurrence	orexin_off Hub1?	orexin_on Hub1?	orexin_off Hub2?	orexin_on Hub2?	ConSurf1	ConSurf2
1	1x39	2x60	orexin_off	50.9478	0	Yes	Yes	No	No	7	7
2	E2	NT	orexin_off	27.0737	0	Yes	Yes	Yes	No	3	5
3	5x39	5x43	orexin_off	35.4765	0	Yes	Yes	Yes	No	8	5
4	1x53	7x53	orexin_off	11.8442	0	No	No	Yes	Yes	9	9
5	7x49	7x53	orexin_off	83.0951	0	No	Yes	Yes	Yes	9	9
6	3x36	6x48	orexin_off	99.2098	0	No	No	Yes	Yes	6	7
7	3x36	Lig	orexin_off	100	2.22868	No	No	Yes	Yes	6	0
8	1x57	2x40	orexin_off	16.4774	0	No	No	No	No	7	9
9	2x40	8x50	orexin_off	19.1243	0	No	No	Yes	Yes	9	8
10	7x53	8x50	orexin_off	58.949	0	Yes	Yes	Yes	Yes	9	8
11	1x57	2x44	orexin_off	15.0222	2.04094	No	No	No	No	7	6
12	1x54	1x58	orexin_off	10.6049	0	No	No	No	No	6	3
13	1x54	2x44	orexin_off	13.5584	0	No	No	No	No	6	6
14	3x49	3x50	orexin_off	30.8649	0	No	No	No	No	9	9
15	2x39	3x50	orexin_off	32.9893	0	No	No	No	No	8	9
16	2x39	6x37	orexin_off	34.0343	0	No	No	Yes	No	8	8
17	3x46	6x37	orexin_off	58.1113	0	No	No	Yes	No	8	8
18	2x42	3x45	orexin_off	59.0915	8.51502	Yes	Yes	No	No	8	6
19	3x45	4x49	orexin_off	59.7133	5.68677	No	No	No	No	6	6
20	3x38	4x49	orexin_off	61.2289	0	Yes	No	No	No	7	6
21	3x38	4x53	orexin_off	66.6911	4.98425	Yes	No	No	No	7	8
22	3x37	4x53	orexin_off	67.3993	2.49516	No	No	No	No	7	8
23	3x37	4x56	orexin_off	68.0988	0	No	No	No	No	7	5
24	4x57	5x43	orexin_off	72.8356	9.41134	Yes	No	Yes	No	7	5
25	3x25	E1x50	orexin_off	20.5406	2.1439	No	No	Yes	Yes	9	7
26	3x25	E2	orexin_off	25.4847	0	No	No	Yes	Yes	9	3
27	5x58	6x37	orexin_off	28.5936	9.41739	Yes	Yes	Yes	No	9	8
28	3x52	I2x53	orexin_off	11.0324	0	Yes	No	Yes	No	4	7
29	4x41	I2x53	orexin_off	23.1314	0	No	No	Yes	No	7	7
30	3x54	5x61	orexin_off	18.4118	1.78658	Yes	No	No	No	8	9
31	5x58	5x61	orexin_off	19.5777	3.79118	Yes	Yes	No	No	9	9
32	5x35	E2	orexin_off	10.6006	4.04554	No	No	Yes	Yes	3	3
33	7x39	7x40	orexin_off	25.4113	0	Yes	Yes	No	No	5	8
34	6x36	7x53	orexin_off	20.2599	0	No	No	Yes	Yes	8	9
35	6x36	7x56	orexin_off	18.8739	5.86846	No	No	No	No	8	7
36	2x67	NT	orexin_off	10.0782	0	No	No	Yes	No	4	5
37	7x54	8x54	orexin_off	10.6049	0	No	No	No	Yes	7	7
38	8x50	8x54	orexin_off	27.3241	0	Yes	Yes	No	Yes	8	7
39	1x52	8x58	orexin_off	10.1084	0	Yes	No	No	No	6	5
40	1x52	8x54	orexin_off	15.9938	6.1531	Yes	No	No	Yes	6	7
41	6x35	7x56	orexin_off	17.4964	0	No	No	No	No	8	7
42	6x28	6x32	orexin_off	14.612	0	No	No	No	No	5	8
43	6x32	6x35	orexin_off	16.0586	2.07122	No	No	No	No	8	8
44	6x24	6x28	orexin_off	10.3631	0	No	No	No	No	0	5
45	7x34	7x38	orexin_off	10.4711	0	Yes	No	No	Yes	4	5
46	1x39	7x39	Shared	38.322	61.64	Yes	Yes	Yes	Yes	7	5
47	2x60	Lig	Shared	60.9439	24.5216	No	No	Yes	Yes	7	0
48	4x61	Lig	Shared	45.5892	66.0853	Yes	Yes	Yes	Yes	6	0
49	4x61	E2x52	Shared	24.0511	28.5913	Yes	Yes	Yes	Yes	6	4
50	E2	E2x52	Shared	21.2617	19.5918	Yes	Yes	Yes	Yes	3	4
51	4x61	5x39	Shared	22.4837	37.4576	Yes	Yes	Yes	Yes	6	8
52	5x39	E2	Shared	50.1447	19.0952	Yes	Yes	Yes	Yes	8	3
53	5x43	Lig	Shared	83.1426	13.3539	Yes	No	Yes	Yes	5	0
54	2x57	7x42	Shared	15.5145	21.4935	Yes	Yes	Yes	Yes	7	7
55	3x32	Lig	Shared	20.3204	31.1652	Yes	No	Yes	Yes	7	0
56	1x43	2x57	Shared	16.0586	19.18	No	No	Yes	Yes	6	7
57	1x53	2x47	Shared	10.6049	67.9506	No	No	No	No	9	9
58	7x45	7x49	Shared	89.1921	45.5911	Yes	No	No	Yes	9	9
59	6x48	7x45	Shared	89.3519	46.548	Yes	Yes	Yes	No	7	9
60	1x60	I1x50	Shared	12.086	16.1701	No	Yes	No	Yes	6	8
61	8x50	I1x50	Shared	15.0222	26.0296	Yes	Yes	No	Yes	8	8
62	2x42	3x46	Shared	58.9361	83.0184	Yes	Yes	No	No	8	8
63	4x56	4x57	Shared	72.1145	16.2003	No	No	Yes	No	5	7
64	7x38	Lig	Shared	14.5559	24.679	No	Yes	Yes	Yes	5	0
65	4x41	I2	Shared	26.4994	22.0385	No	No	No	Yes	7	5
66	3x49	I2	Shared	27.6048	62.827	No	No	No	Yes	9	5
67	5x44	5x47	Shared	11.6369	28.4096	No	Yes	Yes	Yes	6	8
68	5x47	6x49	Shared	20.0052	37.5908	Yes	Yes	No	No	8	6
69	6x49	6x50	Shared	21.3697	42.0724	No	No	No	No	6	9
70	6x50	7x40	Shared	22.7255	44.2951	No	No	No	No	9	8
71	1x35	7x35	orexin_on	0	13.0814	No	No	No	No	5	4
72	1x39	7x35	orexin_on	0	17.2783	Yes	Yes	No	No	7	4
73	1x39	7x42	orexin_on	1.46379	81.9525	Yes	Yes	Yes	Yes	7	7
74	1x43	1x47	orexin_on	4.02435	12.0761	No	No	No	No	6	6
75	2x56	7x42	orexin_on	1.08381	21.4692	No	Yes	Yes	Yes	7	7
76	2x53	2x56	orexin_on	0	51.4898	No	No	No	Yes	7	7
77	2x53	7x46	orexin_on	0	51.6897	No	No	No	No	7	9
78	2x50	7x46	orexin_on	1.5372	51.9985	No	Yes	No	No	9	9
79	1x50	2x50	orexin_on	3.07008	79.1303	Yes	Yes	No	Yes	9	9
80	1x50	2x47	orexin_on	9.11525	72.8319	Yes	Yes	No	No	9	9
81	1x53	7x54	orexin_on	0	66.2851	No	No	No	No	9	7
82	7x54	8x50	orexin_on	0	58.085	No	No	Yes	Yes	7	8
83	1x60	8x57	orexin_on	0	10.2592	No	Yes	No	No	6	6
84	7x41	7x42	orexin_on	0	39.8014	No	No	Yes	Yes	7	7
85	6x48	7x41	orexin_on	1.5372	100	Yes	Yes	No	No	7	7
86	6x44	6x48	orexin_on	8.24733	52.6163	Yes	No	Yes	Yes	9	7
87	5x54	6x44	orexin_on	0	54.1546	No	No	Yes	No	8	9
88	5x54	5x58	orexin_on	0	53.3127	No	No	Yes	Yes	8	9
89	3x50	5x58	orexin_on	0	52.7313	No	No	Yes	Yes	9	9
90	3x46	3x50	orexin_on	0	33.6785	No	No	No	No	8	9
91	3x43	7x49	orexin_on	0	53.8093	No	No	No	Yes	9	9
92	3x43	7x53	orexin_on	0	77.0409	No	No	Yes	Yes	9	9
93	3x46	7x53	orexin_on	0	51.7563	No	No	Yes	Yes	8	9
94	2x46	2x50	orexin_on	0	31.0804	No	Yes	No	Yes	9	9
95	2x46	3x42	orexin_on	0	19.6645	No	Yes	No	No	9	7
96	2x45	3x42	orexin_on	1.52425	17.2481	No	No	No	No	9	7
97	2x45	4x50	orexin_on	3.54938	12.3789	No	No	No	No	9	9
98	2x56	3x32	orexin_on	7.69031	32.6672	No	Yes	Yes	No	7	7
99	2x60	7x42	orexin_on	8.95116	25.4663	No	No	Yes	Yes	7	7
100	7x38	7x42	orexin_on	0	26.2536	No	Yes	Yes	Yes	5	7
101	E1x49	E2	orexin_on	0	19.5312	No	No	Yes	Yes	5	3
102	2x66	E1x49	orexin_on	2.65556	12.1124	No	No	No	No	5	5
103	3x29	Lig	orexin_on	3.07008	21.3542	No	No	Yes	Yes	5	0
104	3x28	3x29	orexin_on	0	18.962	No	No	No	No	5	5
105	3x24	3x28	orexin_on	2.65987	16.9029	No	Yes	No	No	5	5
106	3x24	E1x52	orexin_on	0	10.6529	No	Yes	No	No	5	6
107	4x60	5x39	orexin_on	5.94153	14.656	No	No	Yes	Yes	6	8
108	4x59	4x60	orexin_on	3.96822	12.6393	No	No	No	No	5	6
109	3x30	4x59	orexin_on	0	10.562	No	Yes	No	No	6	5
110	3x33	Lig	orexin_on	0	11.4038	No	No	Yes	Yes	6	0
111	3x33	4x57	orexin_on	2.40943	10.6044	No	No	Yes	No	6	7
112	2x42	3x49	orexin_on	0	65.3888	Yes	Yes	No	No	8	9
113	3x52	I2	orexin_on	0	22.7471	Yes	No	No	Yes	4	5
114	3x51	3x52	orexin_on	7.43124	20.585	Yes	Yes	Yes	No	8	4
115	3x51	3x55	orexin_on	2.49147	12.2759	Yes	Yes	No	No	8	7
116	I2	I2x52	orexin_on	0	10.6468	No	Yes	No	No	5	5
117	4x38	4x41	orexin_on	2.57783	19.8341	No	No	No	No	5	7
118	4x38	4x40	orexin_on	1.29107	17.0361	No	No	No	No	5	5
119	4x40	4x44	orexin_on	0	14.226	No	No	No	No	5	3
120	4x43	4x44	orexin_on	1.5372	11.4038	No	No	No	No	4	3
121	E3	Lig	orexin_on	0	25.9569	Yes	Yes	Yes	Yes	3	0
122	7x36	7x39	orexin_on	0	48.704	No	No	Yes	Yes	4	5
123	7x36	7x40	orexin_on	1.48107	46.5056	No	No	No	No	4	8
124	5x44	6x56	orexin_on	7.33624	16.8241	No	Yes	No	No	6	6
125	6x56	6x60	orexin_on	5.8854	14.4562	No	No	Yes	Yes	6	5
126	5x58	6x41	orexin_on	0	32.0736	Yes	Yes	No	No	9	8
127	6x38	6x41	orexin_on	0	28.4581	No	Yes	No	No	6	8
128	5x62	6x38	orexin_on	0	19.0831	No	No	No	Yes	6	6
129	5x62	5x66	orexin_on	1.29107	15.2616	No	No	Yes	No	6	5
130	5x66	6x31	orexin_on	3.85595	13.3236	Yes	No	No	No	5	5
131	7x55	8x50	orexin_on	0	31.0925	No	No	Yes	Yes	5	8
132	7x51	7x55	orexin_on	1.5372	11.9549	No	No	No	No	6	5
133	6x51	7x41	orexin_on	0	61.4341	No	Yes	No	No	7	7
134	7x55	8x54	orexin_on	0	17.8537	No	No	No	Yes	5	7
135	1x33	1x35	orexin_on	0	10.7134	No	No	No	No	4	5
136	2x46	3x43	orexin_on	3.07008	24.4852	No	Yes	No	No	9	9
137	2x50	7x49	orexin_on	0	25.1696	No	Yes	No	Yes	9	9
138	3x50	7x53	orexin_on	0	19.1134	No	No	Yes	Yes	9	9
139	6x51	Lig	orexin_on	3.07008	58.9147	No	Yes	Yes	Yes	7	0

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
1x39	2x60	orexin_off	5.04417	0	2	1	2	1
1x39	7x42	Shared	4.96417	4.3	2	1	2	2
2x56	3x32	Shared	6.61042	7.12	2	0	2	1
2x56	7x42	Shared	3.8625	6.27	2	0	2	2
2x60	7x42	Shared	9.54833	7.07333	2	1	1	2
2x60	Lig	Shared	6.375	4.27667	2	1	1	0
2x64	7x38	orexin_off	9.45208	0	0	0	2	1
2x67	7x31	Shared	11.2708	11.2233	1	0	2	1
3x28	E1x50	orexin_off	4.6	0	0	0	2	2
3x29	4x65	Shared	8.31833	3.91333	0	0	1	2
3x29	Lig	Shared	12.9583	3.86333	0	0	1	0
3x32	7x42	orexin_off	7.32792	0	2	0	1	2
3x32	Lig	Shared	16.2821	15.2967	2	0	1	0
3x33	4x57	Shared	8.01917	8.02667	0	1	1	2
3x33	4x61	Shared	4.86292	6.14	0	1	1	1
3x36	6x48	orexin_off	5.83708	0	0	0	1	2
3x36	Lig	Shared	3.85667	10.5733	0	0	1	0
4x57	5x43	Shared	5.185	4.98	0	0	2	1
4x61	E2x52	Shared	6.84917	4.24667	0	1	1	2
4x61	5x39	Shared	9.63083	3.75667	0	1	1	2
4x61	Lig	Shared	7.09917	3.37	0	1	1	0
5x40	E2x52	Shared	9.3375	9.03	1	1	2	2
5x39	5x40	Shared	7.21417	4.71667	1	1	2	2
5x39	5x43	orexin_off	4.29792	0	1	1	2	1
5x40	6x55	orexin_off	4.35708	0	1	1	2	1
5x43	5x461	Shared	13.7262	3.89	0	0	1	2
5x43	Lig	Shared	9.85708	6.40667	0	0	1	0
6x48	7x41	Shared	8.77792	4.20333	4	5	2	2
6x51	7x37	Shared	5.54667	4.13	0	1	1	2
6x51	Lig	Shared	12.3458	5.70667	0	1	1	0
6x55	Lig	Shared	10.6925	9.91333	0	0	1	0
6x57	E3	Shared	11.5517	3.98	1	0	2	1
6x58	E3	Shared	3.78458	4.13333	1	1	2	1
6x58	7x34	Shared	4.54792	4.96	1	1	2	2
E3	E3	Shared	13.8737	9.36	1	1	1	1
7x30	E3	Shared	9.57625	9.27	0	1	2	1
7x34	E3	orexin_off	4.33292	0	1	0	2	1
7x27	7x31	Shared	8.91667	6.86	0	1	1	1
7x34	7x38	orexin_off	3.86333	0	1	0	2	1
7x38	Lig	Shared	13.1329	7.78667	0	1	1	0
2x53	3x32	orexin_off	3.51125	0	0	0	2	1
7x26	E3	Shared	3.31792	1.44667	1	1	2	1
2x63	E1x50	orexin_off	2.45	0	0	0	1	2
7x28	7x31	orexin_off	0.747917	0	0	0	2	1
2x60	7x38	orexin_on	0	8.21667	2	1	1	1
2x63	Lig	orexin_on	0	5.05667	0	0	1	0
3x28	3x29	orexin_on	0	3.95333	0	0	2	1
3x33	Lig	orexin_on	0	5.16667	0	1	1	0
4x65	E2x52	orexin_on	0	3.61	0	0	2	2
6x51	7x38	orexin_on	0	5.30333	0	1	1	1
6x51	7x41	orexin_on	0	3.58667	0	1	1	2
7x30	7x34	orexin_on	0	3.93	0	1	2	2
7x31	Lig	orexin_on	0	7.89	0	1	1	0
7x38	7x42	orexin_on	0	5.44333	0	1	1	2
7x41	7x42	orexin_on	0	4.21	0	0	2	2
2x53	2x56	orexin_on	0	3.41333	0	0	2	2
E3	Lig	orexin_on	0	3.72667	1	1	1	0
7x27	Lig	orexin_on	0	6.01667	0	1	1	0
2x59	3x32	orexin_on	0	2.02333	0	0	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	orexin_off	ox2_off ox1_off
	orexin_on	ox2_on

Network Difference
Value	orexin_off	orexin_on
I_min	3.62583	3.34333
Number of Linked Nodes	275	260
Number of Specific Nodes	17 (6.18%)	2 (0.77%)
Number of Shared Nodes	258 (93.82%)	258 (99.23%)
Number of Links	298	288
Number of Specific Links	130 (43.62%)	120 (41.67%)
Number of Shared Links	168 (56.38%)	168 (58.33%)
Number of Hubs	39	35
Number of Specific Hubs	18 (46.15%)	14 (40.00%)
Number of Shared Hubs	21 (53.85%)	21 (60.00%)
Average % Shared Neighbours (Jaccard)	42.96
Average % Shared Neighbours (Otsuka)	52.42
Average % Shared Neighbours (Overlap Coefficient)	61.96
Average % Shared Cliques (k3-6)	79.17
Graphlets Similarity	0.544401

Paths Difference
Value	orexin_off	orexin_on
Number Of Nodes in MetaPath	70	87
Specific Nodes in MetaPath	30 (42.86%)	47 (54.02%)
Shared Nodes in MetaPath	258 (93.82%)	258 (93.82%)
Number Of Links MetaPath	70	94
Specific Links in MetaPath	45 (64.29%)	69 (73.40%)
Shared Links in MetaPath	168 (56.38%)	168 (56.38%)
Number of Shortest Paths	51948	49812
Length Of Smallest Path	3	3
Average Path Length	14.8651	13.6012
Length of Longest Path	38	32
Minimum Path Strength	0.697083	0.731667
Average Path Strength	5.95345	5.49919
Maximum Path Strength	19.1548	20.9667
Minimum Path Correlation	0.700833	0.7
Average Path Correlation	0.927205	0.921507
Maximum Path Correlation	0.99	0.99
Minimum % Of Corr. Nodes	3.33333	3.84615
Average % Of Corr. Nodes	48.9826	45.2673
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	46.6222	43.5399
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download orexin_off_on.zip<

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