psnGPCR

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Orange: nodes, hubs and links specific of orexin_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of orexin_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	orexin_off Int. Strength	orexin_on Int. Strength	orexin_off Hub1?	orexin_on Hub1?	orexin_off Hub2?	orexin_on Hub2?	ConSurf1	ConSurf2
1	NT	NT	orexin_off	100	0	Yes	No	Yes	No	5	5
2	E1x49	NT	orexin_off	100	0	No	No	Yes	No	5	5
3	E1x51	NT	orexin_off	100	0	No	No	Yes	No	4	5
4	E2	NT	orexin_off	100	0	Yes	Yes	Yes	No	3	5
5	2x66	NT	orexin_off	100	0	No	No	Yes	No	5	5
6	2x67	NT	orexin_off	100	0	No	No	Yes	No	4	5
7	1x31	NT	orexin_off	100	0	No	No	Yes	No	4	5
8	1x35	1x39	orexin_off	100	0	No	No	Yes	Yes	5	7
9	1x39	2x60	orexin_off	100	0	Yes	Yes	No	No	7	7
10	1x43	2x54	orexin_off	100	0	No	Yes	No	No	6	7
11	1x49	7x50	orexin_off	100	0	No	No	No	No	8	9
12	1x53	7x53	orexin_off	100	0	No	No	Yes	Yes	9	9
13	1x53	8x50	orexin_off	100	0	No	No	Yes	Yes	9	8
14	1x56	8x53	orexin_off	100	0	No	No	No	Yes	8	7
15	8x49	I1x50	orexin_off	100	0	No	No	No	Yes	7	8
16	2x38	3x49	orexin_off	100	0	No	No	No	No	6	9
17	2x39	3x50	orexin_off	100	0	No	No	No	No	8	9
18	2x39	6x37	orexin_off	100	0	No	No	Yes	No	8	8
19	2x40	8x50	orexin_off	100	0	No	No	Yes	Yes	9	8
20	2x42	3x42	orexin_off	100	0	Yes	Yes	No	No	8	7
21	2x43	7x53	orexin_off	100	0	No	No	Yes	Yes	8	9
22	2x62	E1x52	orexin_off	100	0	No	No	Yes	No	4	6
23	2x66	E1x51	orexin_off	100	0	No	No	No	No	5	4
24	3x28	E1x50	orexin_off	100	0	No	No	Yes	Yes	5	7
25	3x32	7x42	orexin_off	100	0	No	Yes	Yes	Yes	7	7
26	3x34	4x54	orexin_off	100	0	No	No	No	No	5	4
27	3x36	6x48	orexin_off	100	0	No	No	Yes	Yes	6	7
28	3x38	4x53	orexin_off	100	0	Yes	No	No	No	7	8
29	3x40	6x44	orexin_off	100	0	No	No	Yes	No	8	9
30	3x44	5x54	orexin_off	100	0	No	No	No	No	7	8
31	3x46	6x37	orexin_off	100	0	No	No	Yes	No	8	8
32	3x49	3x50	orexin_off	100	0	No	No	No	No	9	9
33	3x50	3x53	orexin_off	100	0	No	No	No	No	9	8
34	3x52	I2x53	orexin_off	100	0	Yes	Yes	No	No	4	7
35	3x54	5x65	orexin_off	100	0	Yes	No	No	Yes	8	8
36	3x54	6x30	orexin_off	100	0	Yes	No	No	No	8	8
37	3x56	I2x51	orexin_off	100	0	Yes	No	No	No	6	7
38	3x56	I2x53	orexin_off	100	0	Yes	No	No	No	6	7
39	I2x51	I2x53	orexin_off	100	0	No	No	No	No	7	7
40	4x38	4x41	orexin_off	100	0	No	No	No	No	5	7
41	4x61	E2x52	orexin_off	100	0	Yes	No	Yes	Yes	6	4
42	4x61	Lig	orexin_off	100	0	Yes	No	Yes	Yes	6	0
43	5x34	5x38	orexin_off	100	0	No	No	No	No	4	4
44	5x39	5x43	orexin_off	100	0	Yes	Yes	Yes	No	8	5
45	5x58	6x38	orexin_off	100	0	Yes	Yes	No	No	9	6
46	5x63	5x68	orexin_off	100	0	No	No	No	No	4	7
47	5x65	5x66	orexin_off	100	0	No	Yes	Yes	No	8	5
48	5x69	6x27	orexin_off	100	0	No	No	No	No	5	4
49	6x35	7x56	orexin_off	100	0	No	No	No	No	8	7
50	6x36	7x53	orexin_off	100	0	No	No	Yes	Yes	8	9
51	6x39	7x52	orexin_off	100	0	No	No	No	No	6	8
52	6x39	7x56	orexin_off	100	0	No	No	No	No	6	7
53	6x40	7x49	orexin_off	100	0	No	No	No	Yes	8	9
54	6x44	7x45	orexin_off	100	0	Yes	No	Yes	No	9	9
55	7x34	E3	orexin_off	100	0	Yes	No	Yes	Yes	4	3
56	7x34	7x38	orexin_off	100	0	Yes	No	No	Yes	4	5
57	7x39	7x40	orexin_off	100	0	Yes	Yes	No	No	5	8
58	7x53	8x50	orexin_off	100	0	Yes	Yes	Yes	Yes	9	8
59	7x54	7x55	orexin_off	100	0	No	No	No	No	7	5
60	7x54	8x51	orexin_off	100	0	No	No	No	No	7	8
61	7x54	8x54	orexin_off	100	0	No	No	No	Yes	7	7
62	8x50	8x54	orexin_off	100	0	Yes	Yes	No	Yes	8	7
63	8x61	8x62	orexin_off	100	0	No	No	No	No	3	1
64	2x41	I1x51	orexin_off	100	0	No	No	No	No	4	8
65	5x40	6x55	orexin_off	100	0	Yes	No	No	No	6	7
66	5x64	5x68	orexin_off	100	0	No	No	No	No	5	7
67	1x59	8x53	orexin_off	100	0	No	No	No	Yes	6	7
68	6x23	I3	orexin_off	100	0	No	No	No	No	0	0
69	6x42	6x46	orexin_off	60	0	No	No	No	No	4	5
70	E1x50	E2	orexin_off	75	0	Yes	Yes	Yes	Yes	7	3
71	2x551	2x56	orexin_off	50	0	Yes	No	Yes	No	5	7
72	1x55	1x59	orexin_off	55	0	No	No	No	No	5	6
73	1x54	1x58	orexin_off	65	0	No	No	No	No	6	3
74	1x35	2x65	orexin_off	60	0	No	No	No	No	5	5
75	2x59	E1x52	orexin_off	65	0	No	No	Yes	No	4	6
76	8x59	CT	orexin_off	50	0	No	No	No	No	4	3
77	3x54	5x64	orexin_off	50	0	Yes	No	No	No	8	5
78	6x56	6x60	orexin_off	75	0	No	No	Yes	No	6	5
79	5x63	5x67	orexin_off	50	0	No	No	No	No	4	5
80	2x551	3x31	orexin_off	50	0	Yes	No	No	No	5	5
81	1x36	2x65	orexin_off	10	0	No	No	No	No	5	5
82	2x52	2x551	orexin_off	55	0	No	No	Yes	No	6	5
83	2x38	4x42	orexin_off	35	0	No	No	No	No	6	7
84	8x60	CT	orexin_off	50	0	No	No	No	No	9	3
85	6x20	6x23	orexin_off	50	0	No	No	No	No	0	0
86	6x53	6x57	orexin_off	5	0	No	No	No	No	5	5
87	2x53	2x56	orexin_off	50	0	No	No	Yes	No	7	7
88	2x46	3x39	orexin_off	50	0	No	Yes	No	No	9	9
89	1x52	8x58	orexin_off	30	0	Yes	No	No	No	6	5
90	1x58	2x44	orexin_off	65	0	No	No	No	No	3	6
91	6x33	6x37	orexin_off	0	0	No	No	Yes	No	8	8
92	2x63	E1x50	orexin_off	0	0	No	No	Yes	Yes	5	7
93	1x57	8x50	orexin_off	0	0	No	No	Yes	Yes	7	8
94	6x28	6x32	orexin_off	55	0	No	No	No	No	5	8
95	1x42	7x47	orexin_off	10	0	No	No	No	No	7	5
96	1x36	1x40	orexin_off	0	0	No	No	No	No	5	3
97	3x55	5x61	orexin_off	25	0	No	No	No	No	7	9
98	2x55	2x551	orexin_off	0	0	No	No	Yes	No	4	5
99	1x52	8x57	orexin_off	10	0	Yes	No	No	No	6	6
100	8x51	8x55	orexin_off	35	0	No	No	No	No	8	5
101	5x71	6x23	orexin_off	50	0	No	No	No	No	0	0
102	5x70	5x71	orexin_off	35	0	No	No	No	No	0	0
103	5x66	6x34	orexin_off	0	0	Yes	No	No	No	5	7
104	4x39	4x43	orexin_off	35	0	No	No	No	No	3	4
105	1x44	1x48	orexin_off	0	0	No	No	No	No	4	4
106	3x52	I2x52	orexin_off	15	0	Yes	Yes	No	No	4	5
107	8x58	8x61	orexin_off	25	0	No	No	No	No	5	3
108	8x63	CT	orexin_off	25	0	No	No	No	No	4	3
109	5x51	5x55	orexin_off	0	0	No	No	No	No	6	5
110	6x54	7x33	orexin_off	0	0	No	No	No	No	5	5
111	1x51	1x55	orexin_off	0	0	No	No	No	No	4	5
112	1x31	1x34	orexin_off	25	0	No	No	No	No	4	6
113	1x33	1x37	orexin_off	20	0	No	Yes	No	No	4	4
114	6x43	7x48	orexin_off	0	0	No	No	No	No	6	6
115	4x59	4x63	orexin_off	0	0	No	No	No	No	5	5
116	5x70	6x31	orexin_off	25	0	No	No	No	No	0	5
117	4x48	4x51	orexin_off	0	0	No	No	No	No	3	3
118	5x38	5x42	orexin_off	0	0	No	No	No	No	4	4
119	7x32	NT	orexin_off	5	0	No	No	Yes	No	1	5
120	5x53	5x56	orexin_off	0	0	No	No	No	No	7	4
121	1x59	8x56	orexin_off	5	0	No	No	No	No	6	4
122	8x60	8x61	orexin_off	5	0	No	No	No	No	9	3
123	1x31	7x28	orexin_off	0	0	No	No	No	No	4	1
124	5x71	5x72	orexin_off	0	0	No	No	No	No	0	0
125	5x34	E2	orexin_off	0	0	No	No	Yes	Yes	4	3
126	6x20	6x22	orexin_off	0	0	No	No	No	No	0	0
127	6x21	6x25	orexin_off	0	0	No	No	No	No	0	3
128	1x41	1x45	orexin_off	0	0	No	No	No	No	3	5
129	6x38	6x42	orexin_off	5	0	No	No	No	No	6	4
130	6x25	I3	orexin_off	5	0	No	No	No	No	3	0
131	1x33	1x34	Shared	100	100	No	Yes	No	No	4	6
132	1x39	2x57	Shared	100	100	Yes	Yes	Yes	Yes	7	7
133	1x39	2x61	Shared	100	100	Yes	Yes	No	No	7	6
134	1x39	7x39	Shared	100	100	Yes	Yes	Yes	Yes	7	5
135	1x39	7x42	Shared	100	100	Yes	Yes	Yes	Yes	7	7
136	1x42	7x39	Shared	100	100	No	No	Yes	Yes	7	5
137	1x43	1x47	Shared	100	100	No	Yes	No	No	6	6
138	1x43	2x57	Shared	100	100	No	Yes	Yes	Yes	6	7
139	1x46	2x54	Shared	100	100	No	No	No	No	8	7
140	1x50	2x47	Shared	100	100	Yes	Yes	No	No	9	9
141	1x50	2x50	Shared	100	100	Yes	Yes	No	Yes	9	9
142	1x50	7x50	Shared	100	100	Yes	Yes	No	No	9	9
143	1x52	8x54	Shared	100	100	Yes	No	No	Yes	6	7
144	1x53	2x47	Shared	100	100	No	No	No	No	9	9
145	1x57	2x44	Shared	100	100	No	No	No	No	7	6
146	1x58	I1x51	Shared	100	0	No	No	No	No	3	8
147	1x60	I1x49	Shared	100	100	No	Yes	No	No	6	5
148	1x60	I1x50	Shared	100	100	No	Yes	No	Yes	6	8
149	1x60	8x53	Shared	100	100	No	Yes	No	Yes	6	7
150	I1x48	I1x51	Shared	100	100	No	No	No	No	7	8
151	8x50	I1x50	Shared	100	100	Yes	Yes	No	Yes	8	8
152	2x37	2x40	Shared	100	100	No	No	No	No	7	9
153	2x38	I2	Shared	100	66.6667	No	No	No	Yes	6	5
154	2x42	3x45	Shared	100	100	Yes	Yes	No	No	8	6
155	2x42	3x46	Shared	100	100	Yes	Yes	No	No	8	8
156	2x42	4x46	Shared	100	100	Yes	Yes	No	No	8	8
157	2x45	3x42	Shared	100	100	No	No	No	No	9	7
158	2x45	4x46	Shared	100	100	No	No	No	No	9	8
159	2x45	4x50	Shared	100	100	No	No	No	No	9	9
160	2x46	3x43	Shared	100	100	No	Yes	No	No	9	9
161	2x50	7x46	Shared	100	100	No	Yes	No	No	9	9
162	2x53	3x35	Shared	100	33.3333	No	No	No	No	7	5
163	2x56	3x32	Shared	100	100	Yes	No	No	Yes	7	7
164	2x56	7x42	Shared	100	100	Yes	No	Yes	Yes	7	7
165	2x57	2x58	Shared	100	66.6667	Yes	Yes	No	No	7	8
166	2x57	7x42	Shared	100	100	Yes	Yes	Yes	Yes	7	7
167	2x60	7x42	Shared	100	100	No	No	Yes	Yes	7	7
168	2x60	Lig	Shared	100	100	No	No	Yes	Yes	7	0
169	2x64	7x35	Shared	100	100	No	No	No	No	5	4
170	2x64	7x38	Shared	100	100	No	No	No	Yes	5	5
171	2x66	E1x49	Shared	100	100	No	No	No	No	5	5
172	E1x49	E1x51	Shared	100	100	No	No	No	No	5	4
173	E1x50	E1x52	Shared	100	100	Yes	Yes	Yes	No	7	6
174	3x25	E1x50	Shared	100	100	No	No	Yes	Yes	9	7
175	E1x50	E2x50	Shared	100	100	Yes	Yes	No	No	7	9
176	3x24	E1x52	Shared	100	100	No	Yes	Yes	No	5	6
177	3x22	E2	Shared	100	100	No	No	Yes	Yes	4	3
178	3x24	3x28	Shared	100	100	No	Yes	No	No	5	5
179	3x25	E2x50	Shared	100	100	No	No	No	No	9	9
180	3x26	E2	Shared	100	33.3333	No	No	Yes	Yes	6	3
181	3x29	4x65	Shared	100	100	No	No	No	No	5	6
182	3x29	Lig	Shared	100	100	No	No	Yes	Yes	5	0
183	3x30	3x34	Shared	100	100	No	No	No	No	6	5
184	3x30	4x54	Shared	100	0	No	No	No	No	6	4
185	3x30	4x62	Shared	100	100	No	No	No	No	6	6
186	3x32	Lig	Shared	100	100	No	Yes	Yes	Yes	7	0
187	3x33	4x57	Shared	100	100	No	No	Yes	Yes	6	7
188	3x33	4x61	Shared	100	100	No	No	Yes	No	6	6
189	3x34	4x57	Shared	100	100	No	No	Yes	Yes	5	7
190	3x36	Lig	Shared	100	100	No	No	Yes	Yes	6	0
191	3x37	4x53	Shared	100	100	No	No	No	No	7	8
192	3x38	4x49	Shared	100	100	Yes	No	No	No	7	6
193	3x38	4x50	Shared	100	100	Yes	No	No	No	7	9
194	3x40	5x50	Shared	100	100	No	No	No	No	8	9
195	3x41	4x49	Shared	100	100	No	No	No	No	6	6
196	3x43	6x44	Shared	100	100	No	No	Yes	No	9	9
197	3x45	4x49	Shared	100	100	No	No	No	No	6	6
198	3x47	5x58	Shared	100	100	No	No	Yes	Yes	8	9
199	3x48	3x52	Shared	100	33.3333	No	No	Yes	Yes	6	4
200	3x49	I2	Shared	100	100	No	No	No	Yes	9	5
201	3x51	3x52	Shared	100	100	Yes	Yes	Yes	Yes	8	4
202	3x51	3x55	Shared	100	100	Yes	Yes	No	No	8	7
203	3x51	3x56	Shared	100	100	Yes	Yes	Yes	No	8	6
204	3x51	5x57	Shared	100	100	Yes	Yes	No	No	8	5
205	3x51	5x60	Shared	100	100	Yes	Yes	No	No	8	5
206	3x56	I2x50	Shared	100	0	Yes	No	No	No	6	9
207	4x56	4x57	Shared	100	66.6667	No	No	Yes	Yes	5	7
208	4x57	5x43	Shared	100	100	Yes	Yes	Yes	No	7	5
209	4x60	5x39	Shared	100	100	No	No	Yes	Yes	6	8
210	4x61	5x39	Shared	100	100	Yes	No	Yes	Yes	6	8
211	4x64	E2x52	Shared	100	100	No	No	Yes	Yes	6	4
212	4x64	E2	Shared	100	100	No	No	Yes	Yes	6	3
213	E2	E2	Shared	100	100	Yes	Yes	Yes	Yes	3	3
214	6x59	E2x51	Shared	100	100	Yes	Yes	No	No	4	5
215	E2	E2x52	Shared	100	100	Yes	Yes	Yes	Yes	3	4
216	5x40	E2x52	Shared	100	100	Yes	No	Yes	Yes	6	4
217	6x59	E2x52	Shared	100	100	Yes	Yes	Yes	Yes	4	4
218	5x35	E2	Shared	100	0	No	No	Yes	Yes	3	3
219	5x36	E2	Shared	100	100	No	No	Yes	Yes	5	3
220	5x39	E2	Shared	100	100	Yes	Yes	Yes	Yes	8	3
221	5x39	5x40	Shared	100	100	Yes	Yes	Yes	No	8	6
222	5x40	6x59	Shared	100	100	Yes	No	Yes	Yes	6	4
223	5x41	6x60	Shared	100	0	No	No	Yes	No	5	5
224	5x43	5x461	Shared	100	100	Yes	No	No	No	5	6
225	5x43	Lig	Shared	100	100	Yes	No	Yes	Yes	5	0
226	5x44	5x47	Shared	100	100	No	No	Yes	Yes	6	8
227	5x44	5x48	Shared	100	0	No	No	No	No	6	5
228	5x44	6x56	Shared	100	100	No	No	No	No	6	6
229	5x47	5x51	Shared	100	100	Yes	Yes	No	No	8	6
230	5x47	6x49	Shared	100	100	Yes	Yes	No	No	8	6
231	5x47	6x52	Shared	100	100	Yes	Yes	No	No	8	6
232	5x54	6x41	Shared	100	100	No	No	No	Yes	8	8
233	5x58	6x37	Shared	100	100	Yes	Yes	Yes	No	9	8
234	5x58	6x41	Shared	100	100	Yes	Yes	No	Yes	9	8
235	5x62	5x66	Shared	100	100	No	No	Yes	No	6	5
236	5x66	6x31	Shared	100	100	Yes	No	No	No	5	5
237	6x27	6x31	Shared	100	100	No	No	No	No	4	5
238	6x36	7x56	Shared	100	100	No	No	No	No	8	7
239	6x40	7x52	Shared	100	100	No	No	No	No	8	8
240	6x43	7x52	Shared	100	0	No	No	No	No	6	8
241	6x44	6x48	Shared	100	100	Yes	No	Yes	Yes	9	7
242	6x47	7x45	Shared	100	100	No	No	Yes	No	8	9
243	6x48	7x41	Shared	100	100	Yes	Yes	No	No	7	7
244	6x48	7x45	Shared	100	100	Yes	Yes	Yes	No	7	9
245	6x51	7x37	Shared	100	100	No	Yes	No	No	7	6
246	6x51	Lig	Shared	100	100	No	Yes	Yes	Yes	7	0
247	6x54	7x34	Shared	100	100	No	No	Yes	No	5	4
248	6x55	Lig	Shared	100	100	No	No	Yes	Yes	7	0
249	6x57	E3	Shared	100	33.3333	No	No	Yes	Yes	5	3
250	6x58	6x59	Shared	100	100	No	No	Yes	Yes	3	4
251	6x58	7x34	Shared	100	100	No	No	Yes	No	3	4
252	6x60	6x61	Shared	100	100	Yes	No	No	No	5	3
253	E3	E3	Shared	100	100	Yes	Yes	Yes	Yes	3	3
254	7x30	E3	Shared	100	100	No	No	Yes	Yes	5	3
255	7x26	E3	Shared	100	33.3333	No	No	Yes	Yes	3	3
256	7x26	7x29	Shared	100	100	No	No	No	No	3	4
257	7x27	7x31	Shared	100	100	No	Yes	No	No	1	3
258	7x36	7x40	Shared	100	100	No	No	No	No	4	8
259	7x38	Lig	Shared	100	100	No	Yes	Yes	Yes	5	0
260	7x39	7x43	Shared	100	100	Yes	Yes	No	No	5	4
261	7x45	7x49	Shared	100	100	Yes	No	No	Yes	9	9
262	7x49	7x53	Shared	100	100	No	Yes	Yes	Yes	9	9
263	8x47	8x50	Shared	100	33.3333	No	No	Yes	Yes	8	8
264	8x48	8x51	Shared	100	100	No	No	No	No	5	8
265	1x32	NT	Shared	100	33.3333	No	No	Yes	No	7	5
266	2x67	7x31	Shared	100	100	No	No	No	No	4	3
267	5x59	5x63	Shared	100	0	No	No	No	No	2	4
268	6x26	6x30	Shared	100	100	No	No	No	No	4	8
269	2x42	4x45	Shared	65	33.3333	Yes	Yes	No	No	8	6
270	1x45	7x47	Shared	40	0	No	No	No	No	5	5
271	4x59	4x60	Shared	45	100	No	No	No	No	5	6
272	1x38	7x39	Shared	50	0	No	No	Yes	Yes	4	5
273	3x54	5x61	Shared	50	100	Yes	No	No	No	8	9
274	3x37	4x57	Shared	15	33.3333	No	No	Yes	Yes	7	7
275	6x49	6x50	Shared	40	100	No	No	No	No	6	9
276	6x50	7x37	Shared	50	100	No	No	No	No	9	6
277	7x51	7x55	Shared	35	33.3333	No	No	No	No	6	5
278	3x27	3x31	Shared	5	33.3333	No	No	No	No	4	5
279	5x51	6x45	Shared	5	0	No	No	No	No	6	5
280	5x62	6x38	Shared	40	100	No	No	No	No	6	6
281	5x45	5x48	Shared	20	0	No	No	No	No	4	5
282	2x41	4x43	Shared	50	33.3333	No	No	No	No	4	4
283	4x41	I2	Shared	35	100	No	No	No	Yes	7	5
284	2x49	3x38	Shared	15	66.6667	No	No	Yes	No	8	7
285	4x52	4x56	Shared	15	0	No	No	No	No	5	5
286	1x50	2x51	Shared	10	100	Yes	Yes	No	No	9	7
287	1x48	1x52	Shared	5	33.3333	No	No	Yes	No	4	6
288	1x54	2x48	Shared	25	0	No	No	No	No	6	5
289	8x52	8x55	Shared	50	33.3333	No	No	No	No	5	5
290	3x21	E1x50	Shared	0	0	No	No	Yes	Yes	8	7
291	5x49	5x50	Shared	10	0	No	No	No	No	5	9
292	6x32	6x35	Shared	50	100	No	No	No	No	8	8
293	4x38	4x40	Shared	15	100	No	No	No	No	5	5
294	6x24	6x28	Shared	10	33.3333	No	No	No	No	0	5
295	4x47	4x51	Shared	0	0	No	No	No	No	3	3
296	5x37	6x60	Shared	10	33.3333	No	No	Yes	No	4	5
297	4x51	4x55	Shared	0	0	No	No	No	No	3	3
298	5x46	5x461	Shared	0	0	No	No	No	No	4	6
299	5x48	5x52	Shared	25	100	No	No	No	No	5	4
300	4x48	4x52	Shared	0	0	No	No	No	No	3	5
301	3x44	5x53	Shared	0	33.3333	No	No	No	No	7	7
302	4x40	4x44	Shared	0	100	No	No	No	No	5	3
303	1x35	7x35	orexin_on	0	100	No	No	No	No	5	4
304	1x39	7x35	orexin_on	0	100	Yes	Yes	No	No	7	4
305	1x53	7x54	orexin_on	0	100	No	No	No	No	9	7
306	1x56	8x54	orexin_on	0	100	No	No	No	Yes	8	7
307	1x58	1x59	orexin_on	0	100	No	No	No	No	3	6
308	1x60	8x57	orexin_on	0	100	No	Yes	No	No	6	6
309	8x53	I1x50	orexin_on	0	100	No	Yes	No	Yes	7	8
310	2x37	2x39	orexin_on	0	100	No	No	No	No	7	8
311	2x43	7x54	orexin_on	0	100	No	No	No	No	8	7
312	2x46	2x50	orexin_on	0	100	No	Yes	No	Yes	9	9
313	2x46	3x42	orexin_on	0	100	No	Yes	No	No	9	7
314	2x46	7x49	orexin_on	0	100	No	Yes	No	Yes	9	9
315	2x50	7x49	orexin_on	0	100	No	Yes	No	Yes	9	9
316	2x52	3x35	orexin_on	0	100	No	No	No	No	6	5
317	2x53	7x46	orexin_on	0	100	No	No	No	No	7	9
318	2x60	7x38	orexin_on	0	100	No	No	No	Yes	7	5
319	2x63	Lig	orexin_on	0	100	No	No	Yes	Yes	5	0
320	2x67	7x27	orexin_on	0	100	No	No	No	Yes	4	1
321	E1x49	E2	orexin_on	0	100	No	No	Yes	Yes	5	3
322	E1x50	Lig	orexin_on	0	100	Yes	Yes	Yes	Yes	7	0
323	3x28	3x29	orexin_on	0	100	No	No	No	No	5	5
324	3x28	3x32	orexin_on	0	100	No	No	No	Yes	5	7
325	3x33	Lig	orexin_on	0	100	No	No	Yes	Yes	6	0
326	3x40	6x48	orexin_on	0	100	No	No	Yes	Yes	8	7
327	3x43	7x53	orexin_on	0	100	No	No	Yes	Yes	9	9
328	3x46	3x50	orexin_on	0	100	No	No	No	No	8	9
329	3x46	7x53	orexin_on	0	100	No	No	Yes	Yes	8	9
330	3x50	5x58	orexin_on	0	100	No	No	Yes	Yes	9	9
331	3x50	7x53	orexin_on	0	100	No	No	Yes	Yes	9	9
332	3x52	I2	orexin_on	0	100	Yes	Yes	No	Yes	4	5
333	3x52	4x41	orexin_on	0	100	Yes	Yes	No	No	4	7
334	3x56	I2x52	orexin_on	0	100	Yes	No	No	No	6	5
335	I2	I2x52	orexin_on	0	100	No	Yes	No	No	5	5
336	4x43	4x44	orexin_on	0	100	No	No	No	No	4	3
337	4x65	E2x52	orexin_on	0	100	No	No	Yes	Yes	6	4
338	7x27	E2	orexin_on	0	100	No	Yes	Yes	Yes	1	3
339	5x54	5x58	orexin_on	0	100	No	No	Yes	Yes	8	9
340	5x54	6x44	orexin_on	0	100	No	No	Yes	No	8	9
341	5x55	6x41	orexin_on	0	100	No	No	No	Yes	5	8
342	5x62	6x34	orexin_on	0	100	No	No	No	No	6	7
343	5x65	6x30	orexin_on	0	100	No	Yes	No	No	8	8
344	6x40	7x53	orexin_on	0	100	No	No	Yes	Yes	8	9
345	6x50	7x40	orexin_on	0	100	No	No	No	No	9	8
346	6x51	7x38	orexin_on	0	100	No	Yes	No	Yes	7	5
347	7x31	Lig	orexin_on	0	100	No	No	Yes	Yes	3	0
348	7x38	7x42	orexin_on	0	100	No	Yes	Yes	Yes	5	7
349	7x52	7x53	orexin_on	0	100	No	No	Yes	Yes	8	9
350	7x54	8x50	orexin_on	0	100	No	No	Yes	Yes	7	8
351	7x55	8x50	orexin_on	0	100	No	No	Yes	Yes	5	8
352	8x49	8x53	orexin_on	0	100	No	No	No	Yes	7	7
353	6x25	6x28	orexin_on	0	100	No	No	No	No	3	5
354	E3	Lig	orexin_on	0	100	Yes	Yes	Yes	Yes	3	0
355	7x27	Lig	orexin_on	0	100	No	Yes	Yes	Yes	1	0
356	7x34	Lig	orexin_on	0	100	Yes	No	Yes	Yes	4	0
357	1x28	7x28	orexin_on	0	100	No	No	No	No	0	1
358	8x54	8x58	orexin_on	0	100	No	Yes	No	No	7	5
359	6x51	7x41	orexin_on	0	66.6667	No	Yes	No	No	7	7
360	4x63	4x64	orexin_on	0	33.3333	No	No	No	No	5	6
361	3x44	5x50	orexin_on	0	66.6667	No	No	No	No	7	9
362	2x50	3x39	orexin_on	0	66.6667	No	Yes	No	No	9	9
363	2x61	2x65	orexin_on	0	33.3333	No	No	No	No	6	5
364	2x40	2x43	orexin_on	0	33.3333	No	No	No	No	9	8
365	2x42	4x42	orexin_on	0	0	Yes	Yes	No	No	8	7
366	I2x50	I2x51	orexin_on	0	66.6667	No	No	No	No	9	7
367	8x55	8x59	orexin_on	0	33.3333	No	No	No	No	5	4
368	5x65	6x33	orexin_on	0	33.3333	No	Yes	No	No	8	8
369	6x57	6x61	orexin_on	0	33.3333	No	No	No	No	5	3
370	1x29	1x31	orexin_on	0	33.3333	No	No	No	No	0	4
371	5x61	6x37	orexin_on	0	33.3333	No	No	Yes	No	9	8
372	5x61	5x65	orexin_on	0	33.3333	No	No	No	Yes	9	8
373	6x49	6x53	orexin_on	0	33.3333	No	No	No	No	6	5
374	6x38	6x41	orexin_on	0	0	No	No	No	Yes	6	8
375	1x48	1x49	orexin_on	0	33.3333	No	No	No	No	4	8
376	3x48	5x53	orexin_on	0	33.3333	No	No	No	No	6	7
377	1x54	2x47	orexin_on	0	33.3333	No	No	No	No	6	9
378	1x33	1x35	orexin_on	0	33.3333	No	Yes	No	No	4	5
379	2x38	4x39	orexin_on	0	33.3333	No	No	No	No	6	3
380	2x41	4x42	orexin_on	0	33.3333	No	No	No	No	4	7
381	7x55	8x54	orexin_on	0	33.3333	No	No	No	Yes	5	7
382	2x62	2x66	orexin_on	0	33.3333	No	No	No	No	4	5
383	1x57	I1x50	orexin_on	0	33.3333	No	No	No	Yes	7	8
384	5x34	5x35	orexin_on	0	33.3333	No	No	No	No	4	3
385	3x23	3x24	orexin_on	0	33.3333	No	No	No	Yes	3	5
386	1x47	2x54	orexin_on	0	0	No	No	No	No	6	7
387	1x37	1x38	orexin_on	0	0	No	No	No	No	4	4
388	6x32	6x36	orexin_on	0	33.3333	No	No	No	No	8	8
389	1x47	2x55	orexin_on	0	33.3333	No	No	No	No	6	4
390	2x551	3x32	orexin_on	0	0	Yes	No	No	Yes	5	7
391	5x64	5x65	orexin_on	0	0	No	No	No	Yes	5	8
392	1x33	NT	orexin_on	0	33.3333	No	Yes	Yes	No	4	5
393	1x46	7x47	orexin_on	0	0	No	No	No	No	8	5
394	1x38	1x41	orexin_on	0	33.3333	No	No	No	No	4	3
395	7x26	7x28	orexin_on	0	33.3333	No	No	No	No	3	1
396	7x29	7x33	orexin_on	0	0	No	No	No	No	4	5
397	1x59	8x57	orexin_on	0	33.3333	No	No	No	No	6	6
398	2x59	3x32	orexin_on	0	0	No	No	No	Yes	4	7
399	1x31	1x32	orexin_on	0	33.3333	No	No	No	No	4	7
400	3x24	3x27	orexin_on	0	0	No	Yes	No	No	5	4
401	1x36	2x61	orexin_on	0	33.3333	No	No	No	No	5	6
402	7x51	7x56	orexin_on	0	0	No	No	No	No	6	7
403	1x55	8x58	orexin_on	0	33.3333	No	No	No	No	5	5
404	1x43	1x44	orexin_on	0	0	No	Yes	No	No	6	4
405	1x30	1x33	orexin_on	0	33.3333	No	No	No	Yes	0	4
406	1x51	2x51	orexin_on	0	0	No	No	No	No	4	7
407	1x60	8x56	orexin_on	0	0	No	Yes	No	No	6	4
408	6x36	6x39	orexin_on	0	33.3333	No	No	No	No	8	6
409	4x55	4x56	orexin_on	0	33.3333	No	No	No	No	3	5
410	5x59	6x38	orexin_on	0	0	No	No	No	No	2	6
411	8x52	8x53	orexin_on	0	0	No	No	No	Yes	5	7
412	1x40	1x43	orexin_on	0	0	No	No	No	Yes	3	6
413	6x28	6x31	orexin_on	0	0	No	No	No	No	5	5
414	6x25	6x29	orexin_on	0	0	No	No	No	No	3	6
415	5x42	5x45	orexin_on	0	0	No	No	No	No	4	4
416	4x47	4x48	orexin_on	0	0	No	No	No	No	3	3
417	5x38	5x41	orexin_on	0	0	No	No	No	No	4	5
418	6x23	6x27	orexin_on	0	0	No	No	No	No	0	4
419	6x23	6x24	orexin_on	0	0	No	No	No	No	0	0
420	5x56	5x60	orexin_on	0	0	No	No	No	No	4	5

Orange: nodes, hubs and links specific of orexin_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of orexin_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	orexin_off Avg Int. Strength	orexin_on Avg Int. Strength	orexin_off Num Of Links	orexin_on Num Of Links	ConSurf
1	NT	orexin_off	50	0	10	2	5
2	1x52	orexin_off	0	0	4	2	6
3	2x551	orexin_off	0	0	4	1	5
4	2x56	orexin_off	0	0	4	2	7
5	E1x52	orexin_off	0	0	4	2	6
6	3x38	orexin_off	40	33.3333	4	3	7
7	3x54	orexin_off	0	0	4	1	8
8	3x56	orexin_off	50	0	4	3	6
9	4x61	orexin_off	50	33.3333	4	2	6
10	5x40	orexin_off	0	0	4	3	6
11	5x43	orexin_off	75	0	4	3	5
12	5x66	orexin_off	0	0	4	2	5
13	6x37	orexin_off	0	0	4	2	8
14	6x44	orexin_off	45	100	4	3	9
15	6x60	orexin_off	0	0	4	3	5
16	7x34	orexin_off	25	33.3333	4	3	4
17	7x45	orexin_off	50	33.3333	4	3	9
18	1x39	Shared	100	100	6	5	7
19	1x50	Shared	0	0	4	4	9
20	2x42	Shared	90	33.3333	5	5	8
21	2x57	Shared	95	33.3333	4	4	7
22	E1x50	Shared	100	100	7	5	7
23	3x51	Shared	100	100	5	5	8
24	3x52	Shared	25	0	4	4	4
25	4x57	Shared	25	33.3333	5	5	7
26	E2	Shared	100	100	12	11	3
27	E2x52	Shared	100	100	5	5	4
28	5x39	Shared	50	33.3333	5	4	8
29	5x47	Shared	70	100	4	4	8
30	5x58	Shared	25	100	4	5	9
31	6x48	Shared	70	66.6667	4	4	7
32	6x59	Shared	90	66.6667	4	4	4
33	E3	Shared	100	100	6	6	3
34	7x39	Shared	75	33.3333	5	4	5
35	7x42	Shared	100	100	5	5	7
36	7x53	Shared	60	100	5	6	9
37	8x50	Shared	100	0	7	4	8
38	Lig	Shared	100	100	9	15	0
39	1x33	orexin_on	0	0	2	4	4
40	1x43	orexin_on	0	0	3	4	6
41	1x60	orexin_on	0	33.3333	3	5	6
42	I1x50	orexin_on	80	33.3333	3	4	8
43	2x46	orexin_on	0	66.6667	2	4	9
44	2x50	orexin_on	35	100	2	5	9
45	3x24	orexin_on	0	0	2	4	5
46	3x32	orexin_on	0	33.3333	3	5	7
47	I2	orexin_on	0	100	3	5	5
48	5x65	orexin_on	0	0	2	4	8
49	6x41	orexin_on	0	0	2	4	8
50	6x51	orexin_on	0	33.3333	2	4	7
51	7x27	orexin_on	0	33.3333	1	4	1
52	7x38	orexin_on	25	66.6667	3	5	5
53	7x49	orexin_on	30	33.3333	3	4	9
54	8x53	orexin_on	0	0	3	4	7
55	8x54	orexin_on	0	0	3	4	7

Orange: nodes, hubs and links specific of orexin_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of orexin_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	orexin_off Recurrence	orexin_on Recurrence	orexin_off Hub1?	orexin_on Hub1?	orexin_off Hub2?	orexin_on Hub2?	ConSurf1	ConSurf2
1	1x31	NT	orexin_off	12.9501	0	No	No	Yes	No	4	5
2	1x39	2x60	orexin_off	30.8063	0	Yes	Yes	No	No	7	7
3	2x60	Lig	orexin_off	42.4141	9.06726	No	No	Yes	Yes	7	0
4	4x61	Lig	orexin_off	50.8701	0	Yes	No	Yes	Yes	6	0
5	4x61	E2x52	orexin_off	26.8999	0	Yes	No	Yes	Yes	6	4
6	E2	E2x52	orexin_off	24.3266	2.72302	Yes	Yes	Yes	Yes	3	4
7	E2	NT	orexin_off	35.2541	0	Yes	Yes	Yes	No	3	5
8	4x61	5x39	orexin_off	25.2013	5.53546	Yes	No	Yes	Yes	6	8
9	5x39	E2	orexin_off	57.734	5.3607	Yes	Yes	Yes	Yes	8	3
10	5x39	5x43	orexin_off	40.6415	0	Yes	Yes	Yes	No	8	5
11	2x60	7x42	orexin_off	10.3073	8.2341	No	No	Yes	Yes	7	7
12	3x32	7x42	orexin_off	10.3397	0	No	Yes	Yes	Yes	7	7
13	3x32	Lig	orexin_off	23.4009	9.26641	No	Yes	Yes	Yes	7	0
14	1x39	7x39	orexin_off	14.1164	9.55497	Yes	Yes	Yes	Yes	7	5
15	1x53	7x53	orexin_off	11.4737	0	No	No	Yes	Yes	9	9
16	3x36	6x48	orexin_off	99.0373	0	No	No	Yes	Yes	6	7
17	3x36	Lig	orexin_off	100	1.36558	No	No	Yes	Yes	6	0
18	1x52	8x54	orexin_off	17.1573	3.68624	Yes	No	No	Yes	6	7
19	8x50	8x54	orexin_off	29.4131	0	Yes	Yes	No	Yes	8	7
20	7x53	8x50	orexin_off	60.7702	0	Yes	Yes	Yes	Yes	9	8
21	1x60	I1x50	orexin_off	13.0658	9.58748	No	Yes	No	Yes	6	8
22	1x57	8x50	orexin_off	16.2409	0	No	No	Yes	Yes	7	8
23	1x57	2x44	orexin_off	14.658	1.22333	No	No	No	No	7	6
24	1x58	2x44	orexin_off	13.0658	0	No	No	No	No	3	6
25	3x49	3x50	orexin_off	10.6544	0	No	No	No	No	9	9
26	2x39	3x50	orexin_off	13.1723	0	No	No	No	No	8	9
27	2x39	6x37	orexin_off	14.3895	0	No	No	Yes	No	8	8
28	3x46	6x37	orexin_off	63.8064	0	No	No	Yes	No	8	8
29	2x42	3x45	orexin_off	64.5654	6.03536	Yes	Yes	No	No	8	6
30	3x45	4x49	orexin_off	65.1717	4.13737	No	No	No	No	6	6
31	3x38	4x49	orexin_off	66.6528	0.796586	Yes	No	No	No	7	6
32	3x38	4x53	orexin_off	72.1836	0	Yes	No	No	No	7	8
33	3x37	4x53	orexin_off	72.8733	2.54013	No	No	No	No	7	8
34	3x37	4x57	orexin_off	73.5536	5.0762	No	No	Yes	Yes	7	7
35	2x56	3x32	orexin_off	11.7329	2.10526	Yes	No	No	Yes	7	7
36	E1x50	E1x52	orexin_off	10.3212	5.58423	Yes	Yes	Yes	No	7	6
37	E1x50	E2	orexin_off	27.9274	0	Yes	Yes	Yes	Yes	7	3
38	5x58	6x37	orexin_off	52.5872	8.89657	Yes	Yes	Yes	No	9	8
39	3x51	3x55	orexin_off	14.5052	1.28429	Yes	Yes	No	No	8	7
40	3x55	5x61	orexin_off	15.7688	0	No	No	No	No	7	9
41	3x54	5x61	orexin_off	17.023	1.03637	Yes	No	No	No	8	9
42	3x54	5x65	orexin_off	26.3723	0	Yes	No	No	Yes	8	8
43	5x65	5x66	orexin_off	27.5479	0	No	Yes	Yes	No	8	5
44	5x58	6x38	orexin_off	45.816	0	Yes	Yes	No	No	9	6
45	5x44	5x47	orexin_off	14.658	7.60415	No	No	Yes	Yes	6	8
46	5x66	6x31	orexin_off	14.3988	9.38427	Yes	No	No	No	5	5
47	7x54	8x54	orexin_off	11.4644	0	No	No	No	Yes	7	7
48	1x52	8x58	orexin_off	10.7933	0	Yes	No	No	No	6	5
49	5x70	6x31	orexin_off	10.5063	0	No	No	No	No	0	5
50	7x34	7x38	orexin_off	11.0247	0	Yes	No	No	Yes	4	5
51	5x43	Lig	Shared	88.1885	20.1138	Yes	No	Yes	Yes	5	0
52	2x57	7x42	Shared	17.8515	16.4479	Yes	Yes	Yes	Yes	7	7
53	1x43	2x57	Shared	18.0829	14.2613	No	Yes	Yes	Yes	6	7
54	1x53	2x47	Shared	11.4644	40.9226	No	No	No	No	9	9
55	7x49	7x53	Shared	80.8757	22.3369	No	Yes	Yes	Yes	9	9
56	7x45	7x49	Shared	87.8367	57.5208	Yes	No	No	Yes	9	9
57	6x48	7x45	Shared	87.7858	58.5288	Yes	Yes	Yes	No	7	9
58	8x50	I1x50	Shared	16.2409	18.7401	Yes	Yes	No	Yes	8	8
59	2x42	3x46	Shared	64.6256	22.7149	Yes	Yes	No	No	8	8
60	4x57	5x43	Shared	77.7516	16.7608	Yes	Yes	Yes	No	7	5
61	7x38	Lig	Shared	15.3707	12.2048	No	Yes	Yes	Yes	5	0
62	5x62	5x66	Shared	41.6921	10.7214	No	No	Yes	No	6	5
63	5x62	6x38	Shared	42.7242	13.1965	No	No	No	No	6	6
64	5x47	6x49	Shared	22.4799	12.5137	Yes	Yes	No	No	8	6
65	6x49	6x50	Shared	24.0165	14.9197	No	No	No	No	6	9
66	6x50	7x37	Shared	25.5438	18.4678	No	No	No	No	9	6
67	6x51	7x37	Shared	27.0619	19.6342	No	Yes	No	No	7	6
68	6x51	Lig	Shared	28.5708	75.0904	No	Yes	Yes	Yes	7	0
69	1x39	7x42	orexin_on	0.689623	15.2652	Yes	Yes	Yes	Yes	7	7
70	2x64	7x38	orexin_on	2.98528	10.2743	No	No	No	Yes	5	5
71	6x51	7x38	orexin_on	0	24.0195	No	Yes	No	Yes	7	5
72	6x51	7x41	orexin_on	0	100	No	Yes	No	No	7	7
73	6x48	7x41	orexin_on	1.66158	99.9715	Yes	Yes	No	No	7	7
74	2x50	7x49	orexin_on	0	46.9457	No	Yes	No	Yes	9	9
75	1x50	2x50	orexin_on	3.31852	47.3481	Yes	Yes	No	Yes	9	9
76	1x50	2x47	orexin_on	9.85374	43.7391	Yes	Yes	No	No	9	9
77	1x53	7x54	orexin_on	0	39.9553	No	No	No	No	9	7
78	7x54	8x50	orexin_on	0	35.2571	No	No	Yes	Yes	7	8
79	7x55	8x50	orexin_on	0	16.2772	No	No	Yes	Yes	5	8
80	6x44	6x48	orexin_on	9.29371	39.5692	Yes	No	Yes	Yes	9	7
81	3x43	6x44	orexin_on	4.96621	23.3327	No	No	Yes	No	9	9
82	3x43	7x53	orexin_on	0	13.6111	No	No	Yes	Yes	9	9
83	3x46	7x53	orexin_on	0	22.4873	No	No	Yes	Yes	8	9
84	2x46	3x42	orexin_on	0	11.3066	No	Yes	No	No	9	7
85	7x27	Lig	orexin_on	0	22.3613	No	Yes	Yes	Yes	1	0
86	7x27	E2	orexin_on	0	20.3861	No	Yes	Yes	Yes	1	3
87	E1x50	Lig	orexin_on	0	10.4735	Yes	Yes	Yes	Yes	7	0
88	3x33	Lig	orexin_on	0	23.1376	No	No	Yes	Yes	6	0
89	3x33	4x57	orexin_on	2.69832	18.0451	No	No	Yes	Yes	6	7
90	3x34	4x57	orexin_on	5.36425	10.124	No	No	Yes	Yes	5	7
91	3x40	6x48	orexin_on	0	24.7836	No	No	Yes	Yes	8	7
92	3x40	5x50	orexin_on	3.31852	23.6578	No	No	No	No	8	9
93	5x54	6x44	orexin_on	0	23.4424	No	No	Yes	No	8	9
94	3x44	5x50	orexin_on	0	21.3818	No	No	No	No	7	9
95	3x44	5x53	orexin_on	2.71684	20.2317	No	No	No	No	7	7
96	3x48	5x53	orexin_on	0	19.0734	No	No	No	No	6	7
97	3x48	3x52	orexin_on	1.36536	17.9069	No	No	Yes	Yes	6	4
98	2x42	4x42	orexin_on	0	11.5058	Yes	Yes	No	No	8	7
99	5x54	6x41	orexin_on	5.40128	14.5824	No	No	No	Yes	8	8
100	6x38	6x41	orexin_on	0	17.1144	No	No	No	Yes	6	8
101	E3	Lig	orexin_on	0	16.3422	Yes	Yes	Yes	Yes	3	0
102	4x56	4x57	orexin_on	7.99315	17.6346	No	No	Yes	Yes	5	7
103	7x38	7x42	orexin_on	0	24.4503	No	Yes	Yes	Yes	5	7

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
1x39	2x60	orexin_off	4.856	0	2	1	2	1
1x39	7x42	Shared	4.6655	5.62333	2	1	2	2
2x56	3x32	Shared	6.254	7.63	2	0	2	1
2x56	7x42	Shared	3.695	5.82333	2	0	2	2
2x60	7x42	Shared	9.8215	8.32333	2	1	1	2
2x60	Lig	Shared	7.1335	5.42667	2	1	1	0
2x64	7x38	Shared	8.8225	5.04	0	0	2	1
E1x50	E1x52	Shared	15.886	13.0267	1	1	1	2
3x25	E1x50	Shared	6.2655	6.53333	1	1	2	1
3x28	E1x50	orexin_off	4.4035	0	0	0	2	1
E1x50	E2x50	Shared	9.7945	16.1067	1	1	1	2
3x25	E2x50	Shared	7.28	6.67333	1	1	2	2
3x29	4x65	Shared	7.8855	3.91333	0	0	1	2
3x29	Lig	Shared	13.456	5.99667	0	0	1	0
3x32	7x42	orexin_off	6.2005	0	2	0	1	2
3x32	Lig	Shared	17.945	15.99	2	0	1	0
3x33	4x57	Shared	7.4935	9.53333	0	0	1	2
3x33	4x61	Shared	4.125	6.14	0	0	1	1
3x36	6x48	orexin_off	6.435	0	0	0	1	2
3x36	Lig	Shared	4.968	10.1867	0	0	1	0
4x57	5x43	Shared	4.9155	4.15	0	0	2	1
4x61	E2x52	orexin_off	7.9645	0	0	0	1	2
4x61	5x39	Shared	9.6965	6.38667	0	0	1	2
4x61	Lig	orexin_off	7.2375	0	0	0	1	0
E2	E2	Shared	50.5395	55.61	1	1	2	2
E2	E2x52	Shared	9.7555	11.2633	1	1	2	2
5x40	E2x52	Shared	9.481	6.15667	1	1	2	2
5x39	E2	Shared	8.9235	4.82	1	1	2	2
5x39	5x40	Shared	5.3365	5.80667	1	1	2	2
5x39	5x43	orexin_off	3.764	0	1	1	2	1
5x43	5x461	Shared	12.9065	8.64667	0	0	1	2
5x43	Lig	Shared	10.659	4.82667	0	0	1	0
6x48	7x41	Shared	8.0115	6.30667	7	0	2	2
6x51	7x37	Shared	5.8035	3.61333	0	1	1	2
6x51	Lig	Shared	11.1675	5.70667	0	1	1	0
6x54	7x34	Shared	11.6325	4.87	0	0	2	1
6x55	Lig	Shared	10.2135	7.77333	0	0	1	0
6x57	E3	Shared	10.9615	2.29333	3	1	2	1
6x58	7x34	Shared	5.3965	5.37333	0	0	2	1
E3	E3	Shared	13.0015	6.46667	3	1	1	1
7x30	E3	Shared	9.2485	8.39333	0	0	2	1
7x34	E3	orexin_off	4.0195	0	3	0	1	1
7x26	E3	Shared	3.713	1.44667	3	1	2	1
7x27	7x31	Shared	11.317	4.11667	0	1	1	1
7x34	7x38	orexin_off	3.6175	0	3	0	1	1
7x38	Lig	Shared	14.06	8.45333	0	1	1	0
2x67	7x31	Shared	5.3875	8.60333	1	1	2	1
5x40	6x55	orexin_off	4.0165	0	1	1	2	1
E1x50	E2	orexin_off	3.454	0	1	1	1	2
2x551	2x56	orexin_off	3.4345	0	0	0	2	2
2x59	E1x52	orexin_off	3.3265	0	0	0	2	2
2x63	E1x50	orexin_off	2.45	0	0	0	1	1
3x21	E1x50	Shared	2.3185	0.94	0	0	2	1
2x60	7x38	orexin_on	0	5.02	2	1	1	1
2x63	Lig	orexin_on	0	4.28333	0	0	1	0
2x67	7x27	orexin_on	0	5.04	1	1	2	1
E1x50	Lig	orexin_on	0	5.02333	1	1	1	0
3x28	3x29	orexin_on	0	3.39	0	0	2	1
3x28	3x32	orexin_on	0	4.57667	0	0	2	1
3x33	Lig	orexin_on	0	4.01667	0	0	1	0
4x65	E2x52	orexin_on	0	5.41333	0	0	2	2
7x27	E2	orexin_on	0	12.3833	0	1	1	2
6x51	7x38	orexin_on	0	7.07	0	1	1	1
7x31	Lig	orexin_on	0	7.89	0	1	1	0
7x38	7x42	orexin_on	0	3.63	0	1	1	2
E3	Lig	orexin_on	0	3.72667	3	1	1	0
7x27	Lig	orexin_on	0	6.01667	0	1	1	0
7x34	Lig	orexin_on	0	3.14667	3	0	1	0
6x51	7x41	orexin_on	0	3.07333	0	1	1	2
2x551	3x32	orexin_on	0	1.88667	0	0	2	1
2x59	3x32	orexin_on	0	1.52	0	0	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	orexin_off	ox2_off ox1_off
	orexin_on	ox2_on

Network Difference
Value	orexin_off	orexin_on
I_min	3.5235	3.08333
Number of Linked Nodes	274	258
Number of Specific Nodes	21 (7.66%)	5 (1.94%)
Number of Shared Nodes	253 (92.34%)	253 (98.06%)
Number of Links	302	290
Number of Specific Links	130 (43.05%)	118 (40.69%)
Number of Shared Links	172 (56.95%)	172 (59.31%)
Number of Hubs	38	38
Number of Specific Hubs	17 (44.74%)	17 (44.74%)
Number of Shared Hubs	21 (55.26%)	21 (55.26%)
Average % Shared Neighbours (Jaccard)	43.32
Average % Shared Neighbours (Otsuka)	52.95
Average % Shared Neighbours (Overlap Coefficient)	62.54
Average % Shared Cliques (k3-6)	53.85
Graphlets Similarity	0.516277

Paths Difference
Value	orexin_off	orexin_on
Number Of Nodes in MetaPath	66	52
Specific Nodes in MetaPath	37 (56.06%)	23 (44.23%)
Shared Nodes in MetaPath	253 (92.34%)	253 (92.34%)
Number Of Links MetaPath	68	53
Specific Links in MetaPath	50 (73.53%)	35 (66.04%)
Shared Links in MetaPath	172 (56.95%)	172 (56.95%)
Number of Shortest Paths	51099	47334
Length Of Smallest Path	3	3
Average Path Length	14.1681	12.3086
Length of Longest Path	35	27
Minimum Path Strength	0.69275	0.513333
Average Path Strength	6.46122	5.5182
Maximum Path Strength	23.0443	20.0867
Minimum Path Correlation	0.7005	0.7
Average Path Correlation	0.925675	0.923166
Maximum Path Correlation	0.99	0.99
Minimum % Of Corr. Nodes	3.125	4.34783
Average % Of Corr. Nodes	49.8689	51.2593
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	48.3615	44.1866
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

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