Orange: nodes, hubs and links specific of orexin_on_gp network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of orexin_off network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.


Index Hub Owner orexin_on_gp Avg Int. Strength orexin_off Avg Int. Strength orexin_on_gp Num Of Links orexin_off Num Of Links ConSurf
1G.S1.02 orexin_on_gp66.66670406
2G.S1.06 orexin_on_gp66.66670408
3G.s1h1.04 orexin_on_gp33.33330409
4G.s1h1.05 orexin_on_gp00409
5G.S2.06 orexin_on_gp00409
6G.S2.08 orexin_on_gp1000506
7G.S3.01 orexin_on_gp33.33330405
8G.S3.03 orexin_on_gp1000708
9G.S3.04 orexin_on_gp00407
10G.S3.05 orexin_on_gp33.33330608
11G.S3.06 orexin_on_gp1000507
12G.s3h2.03 orexin_on_gp1000509
13G.H2.04 orexin_on_gp33.33330409
14G.H2.06 orexin_on_gp1000609
15G.H2.07 orexin_on_gp1000709
16G.h2s4.01 orexin_on_gp1000609
17G.S4.02 orexin_on_gp1000408
18G.S4.03 orexin_on_gp66.66670507
19G.S4.07 orexin_on_gp33.33330408
20G.s4h3.02 orexin_on_gp33.33330409
21G.s4h3.03 orexin_on_gp00408
22G.s4h3.04 orexin_on_gp1000608
23G.H3.01 orexin_on_gp66.66670409
24G.H3.06 orexin_on_gp00406
25G.H3.09 orexin_on_gp66.66670509
26G.H3.13 orexin_on_gp1000606
27G.H3.14 orexin_on_gp00408
28G.H3.17 orexin_on_gp66.66670505
29G.H3.18 orexin_on_gp33.33330409
30G.S5.05 orexin_on_gp66.66670509
31G.s5hg.01 orexin_on_gp00409
32G.HG.01 orexin_on_gp33.33330406
33G.HG.04 orexin_on_gp33.33330408
34G.HG.07 orexin_on_gp00409
35G.hgh4.02 orexin_on_gp66.66670708
36G.hgh4.04 orexin_on_gp33.33330406
37G.hgh4.08 orexin_on_gp00406
38G.hgh4.11 orexin_on_gp00405
39G.H4.07 orexin_on_gp66.66670405
40G.H4.10 orexin_on_gp1000607
41G.H4.15 orexin_on_gp1000508
42G.S6.02 orexin_on_gp1000408
43G.S6.05 orexin_on_gp66.66670405
44G.H5.05 orexin_on_gp33.33330405
45G.H5.08 orexin_on_gp1000608
46G.H5.17 orexin_on_gp00505
47G.H5.23 orexin_on_gp33.33330404
48b.1x1 orexin_on_gp00404
49b.1x11 orexin_on_gp00408
50b.h2x1 orexin_on_gp33.33330405
51b.lhb1x3 orexin_on_gp33.33330402
52b.lhb1x6 orexin_on_gp66.66670403
53b.l1x3 orexin_on_gp1000409
54b.l1x6 orexin_on_gp66.66670509
55b.b2x1 orexin_on_gp1000408
56b.b2x5 orexin_on_gp1000707
57b.b3x3 orexin_on_gp1000408
58b.l3x1 orexin_on_gp66.66670409
59b.l3x2 orexin_on_gp1000409
60b.b4x6 orexin_on_gp1000709
61b.b5x2 orexin_on_gp33.33330407
62b.b5x3 orexin_on_gp1000409
63b.b5x5 orexin_on_gp1000405
64b.b5x7 orexin_on_gp1000407
65b.l5x1 orexin_on_gp66.66670408
66b.l5x5 orexin_on_gp1000709
67b.b6x5 orexin_on_gp1000606
68b.l6x5 orexin_on_gp1000404
69b.b7x1 orexin_on_gp66.66670504
70b.b8x3 orexin_on_gp1000506
71b.b8x4 orexin_on_gp1000506
72b.l8x3 orexin_on_gp00403
73b.b9x3 orexin_on_gp00406
74b.l9x3 orexin_on_gp1000609
75b.l9x6 orexin_on_gp1000608
76b.b10x5 orexin_on_gp1000609
77b.l10x1 orexin_on_gp33.33330403
78b.b11x2 orexin_on_gp1000407
79b.b11x3 orexin_on_gp66.66670405
80b.l11x2 orexin_on_gp1000509
81b.b12x6 orexin_on_gp1000708
82b.b12x7 orexin_on_gp00409
83b.b13x7 orexin_on_gp1000507
84b.l13x3 orexin_on_gp1000509
85b.l13x6 orexin_on_gp1000409
86b.b14x3 orexin_on_gp33.33330405
87b.b14x5 orexin_on_gp00405
88b.b15x1 orexin_on_gp1000709
89b.b15x2 orexin_on_gp1000406
90b.l15x1 orexin_on_gp66.66670407
91b.l15x2 orexin_on_gp1000409
92b.b16x4 orexin_on_gp1000406
93b.b16x5 orexin_on_gp66.66670405
94b.b16x6 orexin_on_gp1000508
95b.b17x2 orexin_on_gp00403
96b.b17x5 orexin_on_gp66.66670407
97b.b17x7 orexin_on_gp66.66670408
98b.l17x3 orexin_on_gp1000709
99b.l17x6 orexin_on_gp66.66670409
100b.l17x7 orexin_on_gp1000407
101b.b18x3 orexin_on_gp66.66670408
102b.b18x5 orexin_on_gp00405
103b.l18x1 orexin_on_gp1000706
104b.l18x2 orexin_on_gp1000407
105b.b19x2 orexin_on_gp1000606
106b.b19x4 orexin_on_gp1000508
107b.l19x2 orexin_on_gp1000509
108b.b20x2 orexin_on_gp1000406
109b.b20x4 orexin_on_gp1000508
110b.b20x6 orexin_on_gp1000706
111b.b21x1 orexin_on_gp1000507
112b.b21x2 orexin_on_gp00406
113b.b21x5 orexin_on_gp33.33330404
114b.b21x7 orexin_on_gp1000605
115b.b22x5 orexin_on_gp1000507
116b.l22x5 orexin_on_gp1000509
117b.b23x6 orexin_on_gp1000707
118b.l23x1 orexin_on_gp00406
119b.b24x4 orexin_on_gp1000406
120b.b24x6 orexin_on_gp33.33330408
121b.b25x3 orexin_on_gp33.33330405
122b.b25x7 orexin_on_gp1000407
123b.l25x3 orexin_on_gp1000509
124b.l25x6 orexin_on_gp66.66670408
125b.b26x3 orexin_on_gp66.66670506
126b.l27x1 orexin_on_gp1000609
127b.l27x2 orexin_on_gp1000409
128b.b28x3 orexin_on_gp66.66670507
129b.b28x4 orexin_on_gp1000406
130b.b28x6 orexin_on_gp1000509
131g.h1x10 orexin_on_gp00409
132g.h1x11 orexin_on_gp00409
133g.h2x9 orexin_on_gp00404
134g.h2x11 orexin_on_gp1000406
135g.ctx3 orexin_on_gp1000509
136g.ctx4 orexin_on_gp00407
137g.ctx6 orexin_on_gp00506
138g.ctx15 orexin_on_gp66.66670409
139g.ctx16 orexin_on_gp1000608
1401x60 orexin_on_gp33.33330536
141I1x50 orexin_on_gp33.333329.1667438
1422x46 orexin_on_gp33.33330429
1432x50 orexin_on_gp66.666741.6667529
1442x56 orexin_on_gp025437
1452x60 orexin_on_gp037.5437
1463x24 orexin_on_gp00415
1473x30 orexin_on_gp00536
1483x43 orexin_on_gp33.33330429
1493x50 orexin_on_gp33.33330439
150I2x51 orexin_on_gp66.66670517
151I2 orexin_on_gp1000525
1524x49 orexin_on_gp33.33330436
1535x44 orexin_on_gp33.333312.5436
1546x30 orexin_on_gp33.33330428
1556x38 orexin_on_gp00426
1566x41 orexin_on_gp00418
1576x51 orexin_on_gp66.66670427
1587x38 orexin_on_gp66.666770.8333435
1597x49 orexin_on_gp33.333337.5439
1608x54 orexin_on_gp00537
1611x39 Shared66.6667100567
1621x50 Shared1000449
1632x42 Shared66.666783.3333458
1642x57 Shared66.666795.8333447
165E1x50 Shared66.6667100467
1663x32 Shared025447
1673x38 Shared66.666741.6667447
1683x51 Shared100100558
1694x61 Shared33.333350446
170E2 Shared10010010114
171E2x52 Shared100100654
1725x39 Shared66.666783.3333558
1735x47 Shared10070.8333448
1745x58 Shared1000649
1756x44 Shared10050549
1766x48 Shared66.666762.5547
1776x59 Shared33.333391.6667444
1786x60 Shared33.33330445
179E3 Shared100100873
1807x34 Shared33.333337.5444
1817x39 Shared33.333375555
1827x42 Shared100100657
1837x53 Shared10062.5559
184Lig Shared1001001590
185NT orexin_off050270
1861x52 orexin_off00246
1872x551 orexin_off00145
1883x52 orexin_off00354
1893x54 orexin_off00248
1903x56 orexin_off050346
191I2x53 orexin_off00247
1924x57 orexin_off66.66670347
1935x40 orexin_off66.666725346
1945x43 orexin_off079.1667345
1955x66 orexin_off012.5245
1966x37 orexin_off00248
1977x45 orexin_off33.333329.1667359
1988x50 orexin_off66.6667100358
1998x53 orexin_off00347
   
Orange: nodes, hubs and links specific of orexin_on_gp network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of orexin_off network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Owner orexin_on_gp Recurrence orexin_off Recurrence orexin_on_gp Hub1? orexin_off Hub1? orexin_on_gp Hub2? orexin_off Hub2? ConSurf1 ConSurf2
1b.b11x5 b.b14x3 orexin_on_gp23.24950NoNoYesNo65
2b.b10x1 b.b11x5 orexin_on_gp36.93860NoNoNoNo96
3b.b10x1 b.l9x6 orexin_on_gp37.05330NoNoYesNo98
4G.s3h2.03 b.l9x6 orexin_on_gp44.75330YesNoYesNo98
5G.H2.07 G.s3h2.03 orexin_on_gp52.41640YesNoYesNo99
6G.H2.04 G.H2.07 orexin_on_gp52.53270YesNoYesNo99
7G.H2.04 G.H3.08 orexin_on_gp52.72760YesNoNoNo98
8G.H3.08 G.S4.04 orexin_on_gp53.06160NoNoNoNo89
9G.H3.09 G.S4.04 orexin_on_gp53.16990YesNoNoNo99
10G.H3.09 G.H4.15 orexin_on_gp95.66370YesNoYesNo98
11G.H3.02 G.H4.15 orexin_on_gp47.8870NoNoYesNo88
12G.H3.02 G.hgh4.02 orexin_on_gp47.89830NoNoYesNo88
13G.hgh4.01 G.hgh4.02 orexin_on_gp96.9430NoNoYesNo68
14G.hgh4.01 G.s4h3.04 orexin_on_gp97.06140NoNoYesNo68
15G.HG.07 G.s4h3.04 orexin_on_gp99.72870YesNoYesNo98
16G.HG.07 G.s4h3.02 orexin_on_gp50.01710YesNoYesNo99
17G.s4h3.02 G.s5hg.01 orexin_on_gp49.87690YesNoYesNo99
18G.S5.07 G.s5hg.01 orexin_on_gp1000NoNoYesNo99
19G.H1.04 G.S5.07 orexin_on_gp99.75710NoNoNoNo79
20G.H1.04 G.H1.08 orexin_on_gp99.78030NoNoNoNo79
21G.H3.06 G.H4.15 orexin_on_gp48.01010YesNoYesNo68
22G.H3.06 G.hgh4.02 orexin_on_gp47.89510YesNoYesNo68
23G.HG.03 G.HG.07 orexin_on_gp49.86570NoNoYesNo69
24G.HG.03 G.s5hg.01 orexin_on_gp49.8770NoNoYesNo69
25G.hns1.01 b.l1x4 orexin_on_gp10.01840NoNoNoNo46
26G.S1.03 G.hns1.01 orexin_on_gp10.14070NoNoNoNo94
27G.S3.06 G.h2s4.01 orexin_on_gp11.00320YesNoYesNo79
28G.S1.03 G.S3.06 orexin_on_gp10.26440NoNoYesNo97
29G.H1.08 G.S3.05 orexin_on_gp98.62150NoNoYesNo98
30G.S3.05 G.S4.03 orexin_on_gp98.58270YesNoYesNo87
31G.S1.05 G.h2s4.01 orexin_on_gp12.15750NoNoYesNo99
32G.H3.18 G.S4.02 orexin_on_gp28.78850YesNoYesNo98
33G.S1.05 G.S4.02 orexin_on_gp12.37650NoNoYesNo98
34G.S4.03 G.S5.05 orexin_on_gp99.64690YesNoYesNo79
35G.H3.17 b.l25x6 orexin_on_gp27.32140YesNoYesNo58
36b.b22x1 b.l25x6 orexin_on_gp13.01290NoNoYesNo88
37b.b22x1 b.b22x2 orexin_on_gp12.92880NoNoNoNo88
38b.b22x2 b.b26x3 orexin_on_gp12.81220NoNoYesNo86
39G.S5.03 G.S5.05 orexin_on_gp49.72790NoNoYesNo99
40G.S4.02 G.S5.02 orexin_on_gp41.48460YesNoNoNo86
41G.H5.10 G.S6.02 orexin_on_gp99.38560NoNoYesNo78
42G.H5.10 G.S5.03 orexin_on_gp49.68650NoNoNoNo79
43G.H5.10 G.S6.04 orexin_on_gp49.75460NoNoNoNo79
44G.S5.05 G.S6.04 orexin_on_gp49.89910YesNoNoNo99
45G.H5.13 G.S6.02 orexin_on_gp49.81780NoNoYesNo88
46G.H5.13 G.H5.17 orexin_on_gp49.75570NoNoYesNo85
476x26 G.h4s6.20 orexin_on_gp49.34120NoNoNoNo44
48G.S6.02 G.h4s6.20 orexin_on_gp49.40170YesNoNoNo84
496x30 G.H5.17 orexin_on_gp49.32040YesNoYesNo85
506x26 6x30 orexin_on_gp49.27891.29107NoNoYesNo48
511x53 7x54 orexin_on_gp14.82690NoNoNoNo97
521x50 2x47 orexin_on_gp15.94439.11525YesYesNoNo99
531x50 2x50 orexin_on_gp17.06153.07008YesYesYesNo99
542x46 3x43 orexin_on_gp10.28343.07008YesNoYesNo99
553x43 7x53 orexin_on_gp43.1140YesNoYesYes99
563x50 7x53 orexin_on_gp43.77470YesNoYesYes99
573x50 G.H5.25 orexin_on_gp71.49270YesNoNoNo98
586x33 G.H5.25 orexin_on_gp97.55950NoNoNoNo88
595x65 6x33 orexin_on_gp97.69090NoNoNoNo88
605x65 6x30 orexin_on_gp97.82230NoNoYesNo88
613x50 5x58 orexin_on_gp25.8150YesNoYesYes99
626x37 G.H5.25 orexin_on_gp25.93840NoYesNoNo88
63b.b15x1 b.b16x6 orexin_on_gp12.640YesNoYesNo98
64b.b16x6 b.b17x3 orexin_on_gp12.50710YesNoNoNo85
65b.b17x3 g.h1x10 orexin_on_gp24.57310NoNoYesNo59
66g.h1x10 g.h1x13 orexin_on_gp17.99240YesNoNoNo91
67b.b17x2 g.h1x13 orexin_on_gp17.75640YesNoNoNo31
68b.b17x2 b.l16x3 orexin_on_gp17.04750YesNoNoNo33
69b.l16x2 b.l16x3 orexin_on_gp16.81270NoNoNoNo93
70b.l14x5 b.l16x2 orexin_on_gp16.57660NoNoNoNo59
71b.l14x3 b.l14x5 orexin_on_gp16.34050NoNoNoNo55
72b.l14x1 b.l14x3 orexin_on_gp16.10430NoNoNoNo45
73b.b18x5 b.l14x1 orexin_on_gp15.86810YesNoNoNo54
74b.b15x2 b.b18x5 orexin_on_gp14.92310YesNoYesNo65
75b.b12x6 b.l9x3 orexin_on_gp11.15590YesNoYesNo89
76b.b11x5 b.l13x7 orexin_on_gp13.59740NoNoNoNo69
77b.l13x3 b.l13x7 orexin_on_gp13.47930YesNoNoNo99
78b.b16x4 b.l13x3 orexin_on_gp12.66290YesNoYesNo69
79b.b21x7 b.b24x6 orexin_on_gp11.34350YesNoYesNo58
80b.b23x6 b.b24x6 orexin_on_gp11.79470YesNoYesNo78
81b.l21x7 b.l23x1 orexin_on_gp14.16940NoNoYesNo56
827x41 7x42 orexin_on_gp14.08540NoNoYesYes77
836x48 7x41 orexin_on_gp15.74771.5372YesYesNoNo77
846x44 6x48 orexin_on_gp56.78268.24733YesYesYesYes97
853x43 6x44 orexin_on_gp22.87044.59433YesNoYesYes99
865x54 6x44 orexin_on_gp45.59750NoNoYesYes89
875x54 5x58 orexin_on_gp45.82880NoNoYesYes89
88G.H3.15 G.H3.17 orexin_on_gp28.46580NoNoYesNo85
89b.l23x1 b.l25x6 orexin_on_gp14.37390YesNoYesNo68
90b.b23x6 b.l21x7 orexin_on_gp13.56940YesNoNoNo75
91G.H3.09 G.S5.02 orexin_on_gp41.4440YesNoNoNo96
92b.b16x4 b.b17x3 orexin_on_gp12.30150YesNoNoNo65
93b.b14x3 b.b15x1 orexin_on_gp13.35010YesNoYesNo59
94G.H3.15 G.H3.18 orexin_on_gp28.51010NoNoYesNo89
951x53 2x47 Shared15.106310.6049NoNoNoNo99
965x58 6x37 Shared25.803428.5936YesYesNoYes98
973x36 Lig Shared40.2883100NoNoYesYes60
983x36 6x48 Shared40.692499.2098NoNoYesYes67
994x61 Lig Shared18.774245.5892YesYesYesYes60
1004x61 5x39 Shared10.015522.4837YesYesYesYes68
1011x39 7x39 orexin_off2.9268138.322YesYesYesYes75
1021x39 2x60 orexin_off050.9478YesYesYesNo77
1032x60 Lig orexin_off0.8547660.9439YesNoYesYes70
1044x61 E2x52 orexin_off8.3445324.0511YesYesYesYes64
105E2 E2x52 orexin_off5.8421521.2617YesYesYesYes44
106E2 NT orexin_off027.0737YesYesNoYes40
1075x39 E2 orexin_off5.8416250.1447YesYesYesYes84
1085x43 Lig orexin_off2.4948383.1426NoYesYesYes50
1095x39 5x43 orexin_off035.4765YesYesNoYes85
1102x57 7x42 orexin_off4.1770915.5145YesYesYesYes77
1113x32 Lig orexin_off3.7889220.3204YesYesYesYes70
1121x43 2x57 orexin_off3.3435716.0586NoNoYesYes67
1131x53 7x53 orexin_off011.8442NoNoYesYes99
1147x49 7x53 orexin_off083.0951YesNoYesYes99
1157x45 7x49 orexin_off0.34344289.1921NoYesYesNo99
1166x48 7x45 orexin_off0.068905389.3519YesYesNoYes79
1171x57 2x40 orexin_off016.4774NoNoNoNo79
1182x40 8x50 orexin_off019.1243NoNoNoYes98
1197x53 8x50 orexin_off058.949YesYesNoYes98
1201x57 2x44 orexin_off0.28038515.0222NoNoNoNo76
1211x60 I1x50 orexin_off1.6818412.086YesNoYesNo68
1228x50 I1x50 orexin_off3.6436315.0222NoYesYesNo88
1231x54 1x58 orexin_off010.6049NoNoNoNo63
1241x54 2x44 orexin_off013.5584NoNoNoNo66
1253x49 3x50 orexin_off030.8649NoNoYesNo99
1262x39 3x50 orexin_off032.9893NoNoYesNo89
1272x39 6x37 orexin_off034.0343NoNoNoYes88
1283x46 6x37 orexin_off058.1113NoNoNoYes88
1292x42 3x46 orexin_off1.6741158.9361YesYesNoNo88
1302x42 3x45 orexin_off1.1117359.0915YesYesNoNo86
1313x45 4x49 orexin_off0.97553259.7133NoNoYesNo66
1323x38 4x49 orexin_off0.70730861.2289YesYesYesNo76
1333x38 4x53 orexin_off0.28458766.6911YesYesNoNo78
1343x37 4x53 orexin_off0.14229867.3993NoNoNoNo78
1353x37 4x56 orexin_off068.0988NoNoNoNo75
1364x56 4x57 orexin_off3.342272.1145NoNoNoYes57
1374x57 5x43 orexin_off2.0877972.8356NoYesNoYes75
1383x25 E1x50 orexin_off1.664520.5406NoNoYesYes97
1393x25 E2 orexin_off3.3318625.4847NoNoYesYes94
1407x38 Lig orexin_off0.43171614.5559YesNoYesYes50
1413x52 I2x53 orexin_off011.0324NoYesNoYes47
1424x41 I2x53 orexin_off023.1314NoNoNoYes77
1434x41 I2 orexin_off0.28032826.4994NoNoYesNo75
1443x49 I2 orexin_off3.3634627.6048NoNoYesNo95
1453x54 5x61 orexin_off1.1237718.4118NoYesNoNo89
1465x58 5x61 orexin_off1.4046719.5777YesYesNoNo99
1475x35 E2 orexin_off0.83540110.6006NoNoYesYes34
1485x44 5x47 orexin_off5.0241511.6369YesNoYesYes68
1495x47 6x49 orexin_off2.0962920.0052YesYesNoNo86
1506x49 6x50 orexin_off1.2667721.3697NoNoNoNo69
1516x50 7x40 orexin_off0.83701822.7255NoNoNoNo98
1527x39 7x40 orexin_off025.4113YesYesNoNo58
1536x36 7x53 orexin_off020.2599NoNoYesYes89
1546x36 7x56 orexin_off0.84111618.8739NoNoNoNo87
1552x67 NT orexin_off010.0782NoNoNoYes40
1567x54 8x54 orexin_off010.6049NoNoYesNo77
1578x50 8x54 orexin_off027.3241NoYesYesNo87
1581x52 8x58 orexin_off010.1084NoYesNoNo60
1591x52 8x54 orexin_off0.84111615.9938NoYesYesNo67
1606x35 7x56 orexin_off017.4964NoNoNoNo87
1616x28 6x32 orexin_off014.612NoNoNoNo58
1626x32 6x35 orexin_off0.28038516.0586NoNoNoNo88
1636x24 6x28 orexin_off010.3631NoNoNoNo25
1647x34 7x38 orexin_off010.4711YesYesYesNo45

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Midway



Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Node1Node2OwnerNet1LinkStrengthNet2LinkStrengthComm1Comm2Node1ShellNode2Shell
1x392x60orexin_off5.0441702321
1x397x42Shared4.964174.32322
2x563x32Shared6.610427.122021
2x567x42Shared3.86256.272022
2x607x42Shared9.548337.073332312
2x60LigShared6.3754.276672310
2x647x38orexin_off9.4520800021
2x677x31Shared11.270811.22331021
3x28E1x50orexin_off4.600022
3x294x65Shared8.318333.913330012
3x29LigShared12.95833.863330010
3x327x42orexin_off7.3279202012
3x32LigShared16.282115.29672010
3x334x57Shared8.019178.026670312
3x334x61Shared4.862926.140311
3x366x48Shared5.837082.943330012
3x36LigShared3.8566710.57330010
4x575x43Shared5.1854.980021
4x61E2x52Shared6.849174.246670312
4x615x39Shared9.630833.756670312
4x61LigShared7.099173.370310
5x40E2x52Shared9.33759.031322
5x395x40Shared7.214174.716671322
5x395x43orexin_off4.2979201321
5x406x55orexin_off4.3570801321
5x435x461Shared13.72623.890311
5x43LigShared9.857086.406670310
6x487x41Shared8.777924.203334522
6x517x37Shared5.546674.130312
6x51LigShared12.34585.706670310
6x55LigShared10.69259.913330010
6x57E3Shared11.55173.981021
6x58E3Shared3.784584.133331321
6x587x34Shared4.547924.961322
E3E3Shared13.87379.361311
7x30E3Shared9.576259.270321
7x34E3Shared4.332923.213331321
7x277x31Shared8.916676.860311
7x347x38orexin_off3.8633301321
7x38LigShared13.13297.786670310
2x533x32orexin_off3.5112500021
7x26E3Shared3.317921.446671321
2x63E1x50orexin_off2.4500012
5x465x461orexin_off1.1916700021
7x287x31orexin_off0.74791700021
2x607x38orexin_on_gp08.216672311
2x63Ligorexin_on_gp05.056670010
3x283x29orexin_on_gp03.953330021
3x283x32orexin_on_gp03.203330021
3x33Ligorexin_on_gp05.166670310
4x65E2x52orexin_on_gp03.610022
6x517x38orexin_on_gp05.303330311
6x517x41orexin_on_gp03.586670312
7x307x34orexin_on_gp03.930322
7x31Ligorexin_on_gp07.890310
7x387x42orexin_on_gp05.443330312
7x417x42orexin_on_gp04.210022
2x532x56orexin_on_gp03.413330022
2x602x64orexin_on_gp02.892312
5x461Ligorexin_on_gp03.183330310
E3Ligorexin_on_gp03.726671310
7x27Ligorexin_on_gp06.016670310
2x593x32orexin_on_gp02.023330021

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
Id Description
orexin_on_gp ox2_on_gp
orexin_off ox2_off
ox1_off
Network Difference
Value orexin_on_gp orexin_off
Imin 2.86667 3.62583
Number of Linked Nodes 880 275
Number of Specific Nodes 620 (70.45%) 15  (5.45%)
Number of Shared Nodes 260 (29.55%) 260  (94.55%)
Number of Links 1081 298
Number of Specific Links 912 (84.37%) 129  (43.29%)
Number of Shared Links 169 (15.63%) 169  (56.71%)
Number of Hubs 184 39
Number of Specific Hubs 160 (86.96%) 15  (38.46%)
Number of Shared Hubs 24 (13.04%) 24  (61.54%)
Average % Shared Neighbours (Jaccard) 12.82
Average % Shared Neighbours (Otsuka) 15.73
Average % Shared Neighbours (Overlap Coefficient) 18.72
Average % Shared Cliques (k3-6) 50.96
Graphlets Similarity 0.596562
Paths Difference
Value orexin_on_gp orexin_off
Number Of Nodes in MetaPath 96 70
Specific Nodes in MetaPath 83 (86.46%) 57  (81.43%)
Shared Nodes in MetaPath 260 (29.55%) 260  (29.55%)
Number Of Links MetaPath 100 70
Specific Links in MetaPath 94 (94.00%) 64  (91.43%)
Shared Links in MetaPath 169 (15.63%) 169  (15.63%)
Number of Shortest Paths 11208001 51948
Length Of Smallest Path 3 3
Average Path Length 47.9077 14.8651
Length of Longest Path 72 38
Minimum Path Strength 0.72 0.697083
Average Path Strength 4.82076 5.95345
Maximum Path Strength 20.9667 19.1548
Minimum Path Correlation 0.703333 0.700833
Average Path Correlation 0.99563 0.927205
Maximum Path Correlation 1 0.99
Minimum % Of Corr. Nodes 1.63934 3.33333
Average % Of Corr. Nodes 25.1643 48.9826
Maximum % Of Corr. Nodes 100 100
Minimum Path Hubs % 0 0
Average Path Hubs % 57.7098 46.6222
Maximum Path Hubs % 100 100

Details about the values in these tables can be found in the corresponding documentation page .

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download orexin_off_on_gp.zip<



You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.



You can also  read or  download a guide explaining the meaning of all files and numerical data.