psnGPCR

Press and hold down the left mouse button and move the mouse to rotate.
Press and hold down the central mouse button and move the mouse to translate.
Use the mouse wheel to zoom in or out.
Click on any atom on your molecule and the corresponding residue label will be placed beneath the viewer.

Orange: nodes, hubs and links specific of ot_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of ot_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	ot_off Int. Strength	ot_on Int. Strength	ot_off Hub1?	ot_on Hub1?	ot_off Hub2?	ot_on Hub2?	ConSurf1	ConSurf2
1	1x35	1x39	ot_off	3.98	0	No	No	No	No	5	6
2	1x35	2x64	ot_off	12.99	0	No	No	No	No	5	5
3	1x40	2x61	ot_off	4.76	0	No	No	No	No	4	7
4	1x42	7x43	ot_off	4.28	0	No	No	No	No	7	5
5	1x45	7x51	ot_off	14.81	0	No	No	No	No	5	6
6	1x47	2x51	ot_off	4.15	0	No	No	No	No	6	7
7	1x49	1x52	ot_off	3.92	0	No	No	No	No	8	6
8	1x49	7x50	ot_off	4.06	0	No	No	No	No	8	9
9	1x50	2x47	ot_off	5.96	0	No	No	No	No	9	9
10	1x53	7x53	ot_off	6.31	0	No	No	Yes	Yes	9	9
11	1x54	2x48	ot_off	4.28	0	No	No	No	No	7	6
12	1x57	2x44	ot_off	4.23	0	Yes	No	No	No	7	6
13	2x38	I1x51	ot_off	10.16	0	Yes	No	Yes	No	7	7
14	3x49	I1x51	ot_off	15.13	0	Yes	No	Yes	No	9	7
15	3x50	I1x51	ot_off	6.77	0	Yes	No	Yes	No	9	7
16	3x53	I1x51	ot_off	4.39	0	No	No	Yes	No	8	7
17	I1x51	I2.S147	ot_off	4.18	0	Yes	No	No	No	7	7
18	I1x51	I2.L148	ot_off	5.14	0	Yes	No	No	No	7	5
19	2x37	2x38	ot_off	5.27	0	No	No	Yes	No	8	7
20	2x38	2x42	ot_off	4.28	0	Yes	No	Yes	Yes	7	8
21	2x38	4x39	ot_off	7.46	0	Yes	No	No	No	7	4
22	2x39	2x43	ot_off	4.24	0	Yes	No	No	No	8	7
23	2x39	3x46	ot_off	4.24	0	Yes	No	Yes	No	8	8
24	2x39	6x33	ot_off	4.42	0	Yes	No	No	No	8	8
25	2x39	6x36	ot_off	4.24	0	Yes	No	No	No	8	8
26	2x41	2x45	ot_off	13.58	0	Yes	No	No	Yes	5	9
27	2x41	4x46	ot_off	5.24	0	Yes	No	No	No	5	7
28	2x46	3x43	ot_off	4.15	0	No	No	No	No	9	8
29	2x46	3x46	ot_off	4.24	0	No	No	Yes	No	9	8
30	2x50	3x39	ot_off	4.42	0	Yes	Yes	No	No	9	9
31	2x50	7x49	ot_off	5.53	0	Yes	Yes	No	No	9	9
32	2x56	2x60	ot_off	5.12	0	Yes	Yes	No	Yes	7	7
33	2x60	7x38	ot_off	6.8	0	No	Yes	No	No	7	6
34	2x63	2x64	ot_off	5.58	0	No	No	No	No	5	5
35	2x63	2x67	ot_off	8.02	0	No	No	No	No	5	4
36	2x66	E1x49	ot_off	3.88	0	No	No	No	No	6	5
37	2x66	E1x51	ot_off	8.74	0	No	No	No	No	6	3
38	E1x50	E2.L177	ot_off	4.87	0	Yes	Yes	Yes	No	7	4
39	E1x50	E2x50	ot_off	6.98	0	Yes	Yes	No	No	7	9
40	3x25	E2.L177	ot_off	4.76	0	No	No	Yes	No	9	4
41	3x29	4x65	ot_off	17.37	0	Yes	No	Yes	No	4	6
42	3x29	E2x50	ot_off	6.47	0	Yes	No	No	No	4	9
43	3x29	Lig	ot_off	9.73	0	Yes	No	Yes	Yes	4	0
44	3x30	3x34	ot_off	8.83	0	No	Yes	No	No	7	6
45	3x33	3x37	ot_off	6.09	0	Yes	No	Yes	Yes	5	6
46	3x33	5x43	ot_off	5.71	0	Yes	No	No	No	5	5
47	3x34	4x54	ot_off	4.47	0	No	No	No	No	6	3
48	3x36	6x48	ot_off	5.82	0	No	No	Yes	Yes	6	8
49	3x36	6x52	ot_off	3.73	0	No	No	Yes	Yes	6	7
50	3x36	Lig	ot_off	8.67	0	No	No	Yes	Yes	6	0
51	3x37	4x53	ot_off	4.19	0	Yes	Yes	No	No	6	8
52	3x41	3x44	ot_off	4.69	0	No	No	Yes	No	6	7
53	3x41	5x50	ot_off	4.17	0	No	No	No	No	6	9
54	3x42	4x50	ot_off	4.56	0	No	No	Yes	No	8	9
55	3x43	6x40	ot_off	4.28	0	No	No	Yes	Yes	8	8
56	3x43	6x41	ot_off	4.47	0	No	No	Yes	No	8	8
57	3x44	5x50	ot_off	6.57	0	Yes	No	No	No	7	9
58	3x44	5x54	ot_off	5.54	0	Yes	No	No	No	7	8
59	3x46	6x37	ot_off	4.52	0	Yes	No	No	No	8	8
60	3x47	5x54	ot_off	4.5	0	No	No	No	No	8	8
61	3x49	3x50	ot_off	7.15	0	Yes	No	Yes	No	9	9
62	3x49	3x52	ot_off	4.07	0	Yes	No	No	No	9	3
63	3x50	6x33	ot_off	7.76	0	Yes	No	No	No	9	8
64	3x50	6x34	ot_off	5.23	0	Yes	No	No	No	9	7
65	3x50	6x37	ot_off	9.06	0	Yes	No	No	No	9	8
66	3x52	I2.L148	ot_off	5.54	0	No	No	No	No	3	5
67	3x54	6x30	ot_off	5.82	0	Yes	No	No	No	8	8
68	3x56	I2.R146	ot_off	11.68	0	No	No	No	No	5	5
69	4x61	4x64	ot_off	5.49	0	Yes	Yes	Yes	No	6	5
70	4x64	4x65	ot_off	6.28	0	Yes	No	Yes	No	5	6
71	4x64	5x39	ot_off	12.09	0	Yes	No	Yes	No	5	7
72	4x65	Lig	ot_off	5.6	0	Yes	No	Yes	Yes	6	0
73	E2.R178	E2.S176	ot_off	10.54	0	No	No	No	No	3	5
74	E2.D186	E2.V180	ot_off	4.38	0	No	No	No	No	4	3
75	E2.D186	E2x51	ot_off	11.17	0	No	No	No	No	4	3
76	5x35	E2.F191	ot_off	4.52	0	No	No	Yes	No	4	6
77	5x39	E2.F191	ot_off	6.19	0	Yes	No	Yes	No	7	6
78	E2.I192	E2.R193	ot_off	3.76	0	No	No	No	No	4	4
79	5x34	E2.I192	ot_off	4.7	0	Yes	No	No	No	2	4
80	E2.P194	E2.R193	ot_off	5.76	0	No	No	No	No	4	4
81	5x34	E2.R193	ot_off	9	0	Yes	No	No	No	2	4
82	5x34	5x35	ot_off	5.63	0	Yes	No	No	No	2	4
83	5x40	Lig	ot_off	5.47	0	No	No	Yes	Yes	5	0
84	5x42	5x46	ot_off	7.78	0	No	No	No	No	4	4
85	5x54	6x41	ot_off	11.92	0	No	No	Yes	No	8	8
86	5x58	6x38	ot_off	13.41	0	Yes	Yes	No	No	9	6
87	5x58	6x41	ot_off	6.31	0	Yes	Yes	Yes	No	9	8
88	5x64	6x25	ot_off	14.1	0	No	No	No	No	6	3
89	6x27	6x30	ot_off	6.12	0	No	No	No	No	4	8
90	6x36	8x47	ot_off	5.78	0	No	No	No	No	8	8
91	6x39	7x56	ot_off	6.28	0	No	No	Yes	No	7	7
92	6x40	7x49	ot_off	5.82	0	Yes	Yes	No	No	8	9
93	6x40	7x52	ot_off	4.42	0	Yes	Yes	No	No	8	8
94	6x48	6x51	ot_off	4.01	0	Yes	Yes	Yes	Yes	8	7
95	6x48	7x41	ot_off	7.78	0	Yes	Yes	No	No	8	7
96	6x48	Lig	ot_off	7.86	0	Yes	Yes	Yes	Yes	8	0
97	6x51	6x55	ot_off	8.2	0	Yes	Yes	No	No	7	6
98	6x56	6x60	ot_off	6.98	0	No	No	No	No	6	5
99	6x57	E3.A302	ot_off	3.89	0	No	No	No	No	4	4
100	E3.N303	E3.P305	ot_off	6.52	0	No	No	No	No	3	4
101	7x29	7x32	ot_off	10.71	0	No	No	No	No	4	2
102	7x35	7x39	ot_off	4.28	0	No	No	No	No	4	5
103	7x45	7x49	ot_off	12.59	0	No	No	No	No	9	9
104	7x55	7x56	ot_off	3.65	0	No	No	Yes	No	5	7
105	6x50	7x37	ot_off	3.53	0	No	No	No	No	9	5
106	6x55	7x34	ot_off	3.51	0	No	No	Yes	No	6	4
107	6x30	I2.P144	ot_off	3.35	0	No	No	No	No	8	9
108	2x58	2x59	ot_off	3.28	0	No	No	No	No	8	4
109	6x50	7x40	ot_off	3.28	0	No	No	No	No	9	7
110	4x39	4x43	ot_off	3.2	0	No	No	No	No	4	3
111	1x38	1x42	ot_off	3.07	0	No	No	No	No	4	7
112	3x54	6x34	ot_off	3.07	0	Yes	No	No	No	8	7
113	5x61	6x34	ot_off	3.07	0	Yes	No	No	No	8	7
114	5x44	5x48	ot_off	3.04	0	No	No	No	No	5	5
115	1x54	2x47	ot_off	3	0	No	No	No	No	7	9
116	1x36	2x61	ot_off	2.98	0	No	No	No	No	6	7
117	1x38	7x39	ot_off	2.98	0	No	No	No	No	4	5
118	1x53	1x57	ot_off	2.98	0	No	No	Yes	No	9	7
119	3x42	4x49	ot_off	2.95	0	No	No	No	No	8	7
120	3x22	E2.S176	ot_off	2.94	0	No	No	No	No	4	5
121	5x61	5x65	ot_off	2.94	0	Yes	No	No	No	8	8
122	6x26	6x31	ot_off	2.94	0	No	No	No	No	6	6
123	3x54	5x64	ot_off	2.91	0	Yes	No	No	No	8	6
124	1x39	7x38	ot_off	2.83	0	No	No	No	No	6	6
125	4x60	5x39	ot_off	2.78	0	No	No	Yes	No	7	7
126	2x42	4x42	ot_off	2.77	0	Yes	Yes	No	No	8	7
127	5x67	5x68	ot_off	2.64	0	No	No	No	No	5	7
128	2x49	4x50	ot_off	2.59	0	No	No	Yes	No	8	9
129	4x38	4x41	ot_off	2.59	0	No	No	No	No	4	7
130	1x57	2x40	ot_off	2.44	0	Yes	No	No	No	7	9
131	3x23	3x26	ot_off	2.43	0	No	No	No	No	3	6
132	3x30	3x31	ot_off	2.34	0	No	Yes	No	No	7	5
133	4x38	4x40	ot_off	2.13	0	No	No	No	No	4	5
134	E3.A304	E3.P305	ot_off	1.87	0	No	No	No	No	3	4
135	2x54	7x46	ot_off	1.81	0	No	No	No	No	7	9
136	6x43	7x48	ot_off	1.81	0	No	No	No	No	6	6
137	E2.A181	E2.V180	ot_off	1.7	0	No	No	No	No	3	3
138	E2.A181	E2.V184	ot_off	1.7	0	No	No	No	No	3	3
139	E2.E179	E2.G183	ot_off	1.64	0	No	No	No	No	3	4
140	7x30	E3.P305	ot_off	1.57	0	No	No	No	No	4	4
141	6x45	6x46	ot_off	1.54	0	No	No	No	No	6	6
142	2x65	2x66	ot_off	1.52	0	No	No	No	No	5	6
143	3x28	3x29	ot_off	1.52	0	No	No	Yes	No	6	4
144	3x54	6x31	ot_off	1.47	0	Yes	No	No	No	8	6
145	4x41	I2.L148	ot_off	1.47	0	No	No	No	No	7	5
146	6x28	6x31	ot_off	1.45	0	No	No	No	No	6	6
147	7x33	7x34	ot_off	1.39	0	No	No	Yes	No	5	4
148	1x57	8x50	ot_off	1.38	0	Yes	No	No	No	7	8
149	4x47	4x51	ot_off	1.38	0	No	No	No	No	3	4
150	1x58	2x44	ot_off	1.31	0	No	No	No	No	2	6
151	E2.D182	E2.E179	ot_off	1.3	0	No	No	No	No	3	3
152	7x53	7x54	ot_off	1.2	0	Yes	Yes	No	No	9	7
153	1x28	1x31	Shared	9.61	6.87	No	No	No	No	5	5
154	1x29	1x33	Shared	6.98	15.12	No	No	No	No	5	5
155	1x39	2x61	Shared	4.15	8.3	No	No	No	No	6	7
156	1x42	7x47	Shared	6.55	3.27	No	No	No	No	7	7
157	1x43	1x47	Shared	4.15	6.92	No	No	No	No	6	6
158	1x43	2x57	Shared	5.96	4.47	No	No	No	No	6	7
159	1x45	7x47	Shared	6.35	4.76	No	No	No	No	5	7
160	1x48	1x49	Shared	3.71	1.86	No	No	No	No	4	8
161	1x50	7x50	Shared	11.4	6.52	No	No	No	No	9	9
162	1x53	2x47	Shared	4.85	9.7	No	No	No	No	9	9
163	1x56	8x50	Shared	4.73	4.73	No	No	No	No	7	8
164	2x39	3x50	Shared	9.72	2.43	Yes	No	Yes	No	8	9
165	2x41	2x42	Shared	4.29	5.36	Yes	No	Yes	Yes	5	8
166	2x42	3x45	Shared	9.74	6.09	Yes	Yes	No	No	8	7
167	2x42	3x46	Shared	4.98	8.71	Yes	Yes	Yes	No	8	8
168	2x42	3x49	Shared	9.55	10.75	Yes	Yes	Yes	No	8	9
169	2x43	7x53	Shared	16.76	4.79	No	No	Yes	Yes	7	9
170	2x45	4x46	Shared	8.3	12.45	No	Yes	No	No	9	7
171	2x45	4x50	Shared	5.29	3.17	No	Yes	Yes	No	9	9
172	2x46	2x50	Shared	4.07	6.79	No	No	Yes	Yes	9	9
173	2x50	7x46	Shared	4.67	11.78	Yes	Yes	No	No	9	9
174	2x55	2x551	Shared	7.87	5.24	No	No	No	No	5	5
175	2x551	3x31	Shared	10.96	20.7	No	No	No	No	5	5
176	2x56	3x32	Shared	11.52	7.68	Yes	Yes	No	Yes	7	7
177	2x56	7x42	Shared	4.33	7.22	Yes	Yes	No	No	7	7
178	2x56	Lig	Shared	30.6	19.16	Yes	Yes	Yes	Yes	7	0
179	E1x49	E1x51	Shared	23.66	4.12	No	No	No	No	5	3
180	E1x49	E2.V184	Shared	7.85	6.54	No	No	No	No	5	3
181	E1x50	E1x52	Shared	4.52	4.52	Yes	Yes	No	No	7	6
182	3x25	E1x50	Shared	6.98	4.19	No	No	Yes	Yes	9	7
183	3x21	E1x52	Shared	4.06	4.06	No	No	No	No	7	6
184	3x21	3x24	Shared	11.49	8.21	No	No	No	No	7	5
185	3x22	3x26	Shared	16.68	17.87	No	No	No	No	4	6
186	3x22	E2.L177	Shared	9.5	21.71	No	No	Yes	No	4	4
187	3x25	E2x50	Shared	5.46	5.46	No	No	No	No	9	9
188	3x26	4x62	Shared	5.23	3.92	No	No	No	No	6	5
189	3x27	3x31	Shared	4.15	2.77	No	No	No	No	5	5
190	3x29	3x32	Shared	8.14	9.49	Yes	No	No	Yes	4	7
191	3x30	4x54	Shared	5.86	7.03	No	Yes	No	No	7	3
192	3x32	Lig	Shared	16.32	5.64	No	Yes	Yes	Yes	7	0
193	3x33	4x57	Shared	9.01	6.46	Yes	No	No	No	5	7
194	3x33	4x61	Shared	14.64	10.03	Yes	No	Yes	Yes	5	6
195	3x34	4x57	Shared	6.46	4.85	No	No	No	No	6	7
196	3x37	3x41	Shared	6.19	11.35	Yes	Yes	No	No	6	6
197	3x37	4x56	Shared	7.87	8.32	Yes	Yes	No	No	6	5
198	3x37	5x461	Shared	7.87	5.24	Yes	Yes	No	No	6	5
199	3x38	4x50	Shared	5.19	5.19	No	No	Yes	No	7	9
200	3x40	6x44	Shared	7.78	3.89	No	No	No	No	8	9
201	3x47	5x58	Shared	6.36	6.36	No	No	Yes	Yes	8	9
202	3x48	5x57	Shared	4.76	3.17	No	No	No	Yes	6	6
203	3x51	5x57	Shared	7.28	7.28	No	No	No	Yes	7	6
204	3x51	5x61	Shared	4.91	4.91	No	No	Yes	No	7	8
205	3x54	5x61	Shared	10.3	2.94	Yes	No	Yes	No	8	8
206	4x61	4x65	Shared	5.86	10.54	Yes	Yes	Yes	No	6	6
207	4x61	5x39	Shared	6.76	10.15	Yes	Yes	Yes	No	6	7
208	4x61	Lig	Shared	5.1	8.23	Yes	Yes	Yes	Yes	6	0
209	4x64	E2.F191	Shared	6.28	2.51	Yes	No	Yes	No	5	6
210	4x65	E2x52	Shared	6.93	8.32	Yes	No	No	No	6	5
211	E2.R178	E2.V190	Shared	3.92	2.62	No	No	No	No	3	4
212	E2.E179	E2.F185	Shared	8.16	3.5	No	No	No	No	3	3
213	5x36	E2.F191	Shared	21.67	26.01	No	No	Yes	No	5	6
214	5x35	5x36	Shared	4.06	4.06	No	No	No	No	4	5
215	5x37	6x60	Shared	13.92	8.12	No	No	No	No	4	5
216	5x39	5x43	Shared	7.25	13.3	Yes	No	No	No	7	5
217	5x40	6x59	Shared	10.75	9.22	No	No	No	No	5	4
218	5x41	6x56	Shared	6.02	3.01	No	No	No	No	5	6
219	5x42	5x43	Shared	7.05	3.52	No	No	No	No	4	5
220	5x44	6x52	Shared	10.38	9.08	No	No	Yes	Yes	5	7
221	5x44	6x56	Shared	4.52	4.52	No	No	No	No	5	6
222	5x45	5x48	Shared	7.14	1.43	No	No	No	No	5	5
223	5x461	6x52	Shared	3.93	5.24	No	No	Yes	Yes	5	7
224	5x47	5x51	Shared	10.09	5.05	No	Yes	No	No	8	6
225	5x47	6x49	Shared	9.99	1.25	No	Yes	No	No	8	6
226	5x58	6x37	Shared	7.49	7.49	Yes	Yes	No	No	9	8
227	6x32	6x35	Shared	3.71	3.71	No	No	No	No	8	8
228	6x35	7x56	Shared	4.96	7.44	No	No	Yes	No	8	7
229	6x36	7x56	Shared	16.17	4.98	No	No	Yes	No	8	7
230	6x39	7x52	Shared	7.36	1.47	No	No	No	No	7	8
231	6x40	7x53	Shared	6.04	4.84	Yes	Yes	Yes	Yes	8	9
232	6x44	6x48	Shared	10.02	15.03	No	No	Yes	Yes	9	8
233	6x47	7x45	Shared	4.72	9.45	No	No	No	No	8	9
234	6x48	6x52	Shared	8.02	6.01	Yes	Yes	Yes	Yes	8	7
235	6x48	7x45	Shared	13.56	14.69	Yes	Yes	No	No	8	9
236	6x51	6x52	Shared	15	9.65	Yes	Yes	Yes	Yes	7	7
237	6x51	7x41	Shared	4.16	8.32	Yes	Yes	No	No	7	7
238	6x51	Lig	Shared	9.33	5.16	Yes	Yes	Yes	Yes	7	0
239	6x54	7x34	Shared	3.93	10.49	No	No	Yes	No	5	4
240	6x54	7x37	Shared	6.41	4.81	No	No	No	No	5	5
241	6x55	Lig	Shared	10.2	16.73	No	No	Yes	Yes	6	0
242	6x58	7x34	Shared	3.96	2.64	No	No	Yes	No	5	4
243	2x59	3x28	Shared	3.53	3.53	No	No	No	No	4	6
244	5x49	5x50	Shared	3.53	3.53	No	No	No	No	5	9
245	6x49	6x50	Shared	3.5	5.25	No	No	No	No	6	9
246	2x53	7x46	Shared	3.42	4.85	No	No	No	No	7	9
247	7x48	7x52	Shared	3.27	1.64	No	No	No	No	6	8
248	2x57	7x42	Shared	3.23	3.23	No	No	No	No	7	7
249	3x55	5x64	Shared	3.23	4.85	No	No	No	No	7	6
250	3x51	5x60	Shared	3.17	3.17	No	No	No	No	7	6
251	3x45	4x45	Shared	3.15	3.15	No	No	No	No	7	5
252	3x44	5x53	Shared	2.98	10.43	Yes	No	No	No	7	6
253	2x41	4x42	Shared	2.77	6.19	Yes	No	No	No	5	7
254	1x35	7x35	Shared	2.73	4.1	No	No	No	No	5	4
255	5x34	5x38	Shared	2.59	2.59	Yes	No	No	No	2	4
256	6x57	E3.A304	Shared	2.59	2.59	No	No	No	No	4	3
257	6x38	6x42	Shared	2.44	3.65	No	No	No	No	6	5
258	E2.R178	E2x51	Shared	2	6	No	No	No	No	3	3
259	3x35	3x38	Shared	1.95	1.95	No	No	No	No	6	7
260	4x59	4x60	Shared	1.87	1.87	No	No	No	No	4	7
261	1x46	7x47	Shared	1.81	3.61	No	No	No	No	8	7
262	6x46	6x47	Shared	1.71	1.71	No	No	No	No	6	8
263	1x34	1x38	Shared	1.6	1.6	No	No	No	No	5	4
264	3x56	I2.P144	Shared	1.58	1.58	No	No	No	No	5	9
265	6x41	6x45	Shared	1.54	1.54	Yes	No	No	No	8	6
266	1x41	1x44	Shared	1.38	1.38	No	No	No	No	4	4
267	2x52	2x551	Shared	1.31	2.62	No	No	No	No	6	5
268	8x47	8x49	Shared	1.31	6.85	No	No	No	No	8	6
269	E2.F185	E2.L177	Shared	1.22	6.09	No	No	Yes	No	3	4
270	Lig	Lig	ot_on	0	27.89	Yes	Yes	Yes	Yes	0	0
271	7x38	Lig	ot_on	0	3.3	No	No	Yes	Yes	6	0
272	7x39	Lig	ot_on	0	5.04	No	No	Yes	Yes	5	0
273	2x60	Lig	ot_on	0	14.65	No	Yes	Yes	Yes	7	0
274	5x39	Lig	ot_on	0	3.63	Yes	No	Yes	Yes	7	0
275	5x43	Lig	ot_on	0	4.42	No	No	Yes	Yes	5	0
276	6x58	Lig	ot_on	0	7.22	No	No	Yes	Yes	5	0
277	E2x51	Lig	ot_on	0	13.56	No	No	Yes	Yes	3	0
278	7x35	Lig	ot_on	0	7.84	No	No	Yes	Yes	4	0
279	1x35	Lig	ot_on	0	9.91	No	No	Yes	Yes	5	0
280	1x31	1x35	ot_on	0	6.63	No	No	No	No	5	5
281	1x43	2x58	ot_on	0	5.54	No	No	No	No	6	8
282	1x50	2x50	ot_on	0	6.73	No	No	Yes	Yes	9	9
283	1x50	2x51	ot_on	0	5.49	No	No	No	No	9	7
284	2x37	2x40	ot_on	0	5.28	No	No	No	No	8	9
285	2x38	3x49	ot_on	0	7.15	Yes	No	Yes	No	7	9
286	2x38	4x42	ot_on	0	9.26	Yes	No	No	No	7	7
287	2x40	8x50	ot_on	0	7.31	No	No	No	No	9	8
288	2x41	4x39	ot_on	0	7.48	Yes	No	No	No	5	4
289	2x45	3x42	ot_on	0	9	No	Yes	No	No	9	8
290	2x46	3x42	ot_on	0	5.54	No	No	No	No	9	8
291	2x50	7x50	ot_on	0	4.83	Yes	Yes	No	No	9	9
292	2x52	4x50	ot_on	0	3.68	No	No	Yes	No	6	9
293	2x56	3x36	ot_on	0	16.31	Yes	Yes	No	No	7	6
294	2x59	2x60	ot_on	0	6.32	No	No	No	Yes	4	7
295	2x59	3x32	ot_on	0	6.32	No	No	No	Yes	4	7
296	2x60	3x29	ot_on	0	4.07	No	Yes	Yes	No	7	4
297	2x60	3x32	ot_on	0	11.52	No	Yes	No	Yes	7	7
298	2x61	2x65	ot_on	0	4.28	No	No	No	No	7	5
299	2x62	2x66	ot_on	0	4.42	No	No	No	No	4	6
300	2x63	E1x49	ot_on	0	6	No	No	No	No	5	5
301	2x63	E2.D186	ot_on	0	8.93	No	No	No	No	5	4
302	2x64	7x39	ot_on	0	4.07	No	No	No	No	5	5
303	3x24	E1x50	ot_on	0	7.31	No	No	Yes	Yes	5	7
304	E1x50	E2.D186	ot_on	0	3.58	Yes	Yes	No	No	7	4
305	3x28	3x32	ot_on	0	4.3	No	No	No	Yes	6	7
306	3x30	4x57	ot_on	0	8.9	No	Yes	No	No	7	7
307	3x30	4x62	ot_on	0	6.31	No	Yes	No	No	7	5
308	3x39	7x46	ot_on	0	3.26	No	No	No	No	9	9
309	3x40	5x50	ot_on	0	3.5	No	No	No	No	8	9
310	3x40	6x48	ot_on	0	4.85	No	No	Yes	Yes	8	8
311	3x41	4x53	ot_on	0	5.38	No	No	No	No	6	8
312	3x43	7x49	ot_on	0	5.49	No	No	No	No	8	9
313	3x46	7x53	ot_on	0	7.18	Yes	No	Yes	Yes	8	9
314	3x47	5x57	ot_on	0	3.44	No	No	No	Yes	8	6
315	3x50	5x58	ot_on	0	5.14	Yes	No	Yes	Yes	9	9
316	3x52	3x56	ot_on	0	3.99	No	No	No	No	3	5
317	4x40	4x43	ot_on	0	26.66	No	No	No	No	5	3
318	4x41	4x42	ot_on	0	3.75	No	No	No	No	7	7
319	4x43	4x47	ot_on	0	6.07	No	No	No	No	3	3
320	4x63	4x64	ot_on	0	3.98	No	No	Yes	No	5	5
321	E2.I192	E2.Q193	ot_on	0	10.98	No	No	No	No	4	0
322	5x34	E2.Q193	ot_on	0	13.14	Yes	No	No	No	2	0
323	5x35	E2.Q193	ot_on	0	3.29	No	No	No	No	4	0
324	5x34	E2.P194	ot_on	0	4.05	Yes	No	No	No	2	4
325	5x37	6x59	ot_on	0	7.59	No	No	No	No	4	4
326	5x40	6x55	ot_on	0	6.86	No	No	No	No	5	6
327	5x461	6x48	ot_on	0	4.9	No	No	Yes	Yes	5	8
328	5x47	6x45	ot_on	0	6.04	No	Yes	No	No	8	6
329	5x51	6x45	ot_on	0	4.61	No	No	No	No	6	6
330	5x54	5x58	ot_on	0	4.69	No	No	Yes	Yes	8	9
331	5x54	6x40	ot_on	0	4.28	No	No	Yes	Yes	8	8
332	5x54	6x44	ot_on	0	3.65	No	No	No	No	8	9
333	5x58	6x36	ot_on	0	3.59	Yes	Yes	No	No	9	8
334	5x58	6x40	ot_on	0	13.3	Yes	Yes	Yes	Yes	9	8
335	5x62	6x33	ot_on	0	9.59	No	No	No	No	5	8
336	5x62	6x37	ot_on	0	6.4	No	No	No	No	5	8
337	5x63	5x67	ot_on	0	4.68	No	No	No	No	4	5
338	5x64	5x67	ot_on	0	4.07	No	No	No	No	6	5
339	5x65	6x30	ot_on	0	4.36	No	No	No	No	8	8
340	5x65	6x33	ot_on	0	4.56	No	No	No	No	8	8
341	5x66	6x34	ot_on	0	4.9	No	No	No	No	6	7
342	6x32	7x56	ot_on	0	5.34	No	No	Yes	No	8	7
343	6x51	7x38	ot_on	0	3.73	Yes	Yes	No	No	7	6
344	6x53	6x54	ot_on	0	3.93	No	No	No	No	5	5
345	6x53	6x57	ot_on	0	6.01	No	No	No	No	5	4
346	6x58	7x29	ot_on	0	4.59	No	No	No	No	5	4
347	7x49	7x50	ot_on	0	3.26	No	No	No	No	9	9
348	7x49	7x53	ot_on	0	6.98	No	No	Yes	Yes	9	9
349	8x47	8x50	ot_on	0	5.9	No	No	No	No	8	8
350	8x51	8x52	ot_on	0	7.92	No	No	No	No	8	0
351	1x52	7x54	ot_on	0	3.24	No	No	No	No	6	7
352	E2.S176	E2.V190	ot_on	0	3.23	No	No	No	No	5	4
353	6x47	7x43	ot_on	0	3.17	No	No	No	No	8	5
354	1x36	2x65	ot_on	0	3.07	No	No	No	No	6	5
355	1x53	7x54	ot_on	0	3.04	No	No	No	No	9	7
356	3x24	3x28	ot_on	0	2.98	No	No	No	No	5	6
357	6x39	6x40	ot_on	0	2.94	No	No	Yes	Yes	7	8
358	5x47	6x48	ot_on	0	2.89	No	Yes	Yes	Yes	8	8
359	2x38	3x53	ot_on	0	2.77	Yes	No	No	No	7	8
360	3x37	5x46	ot_on	0	2.77	Yes	Yes	No	No	6	4
361	E2.F191	E2x52	ot_on	0	2.77	Yes	No	No	No	6	5
362	7x29	E3.D301	ot_on	0	2.77	No	No	No	No	4	4
363	7x40	7x43	ot_on	0	2.77	No	No	No	No	7	5
364	1x39	2x64	ot_on	0	2.71	No	No	No	No	6	5
365	6x57	E3.P305	ot_on	0	2.7	No	No	No	No	4	4
366	3x30	4x59	ot_on	0	2.67	No	Yes	No	No	7	4
367	2x45	2x48	ot_on	0	2.65	No	Yes	No	No	9	6
368	1x55	8x51	ot_on	0	2.44	No	No	No	No	4	8
369	1x55	1x58	ot_on	0	2.43	No	No	No	No	4	2
370	7x51	7x54	ot_on	0	2.33	No	No	No	No	6	7
371	7x31	E3.P305	ot_on	0	1.87	No	No	No	No	2	4
372	5x59	5x62	ot_on	0	1.86	No	No	No	No	3	5
373	4x52	4x55	ot_on	0	1.84	No	No	No	No	4	3
374	5x53	5x57	ot_on	0	1.71	No	No	No	Yes	6	6
375	5x55	6x41	ot_on	0	1.7	No	No	Yes	No	4	8
376	5x56	5x57	ot_on	0	1.69	No	No	No	Yes	4	6
377	6x43	7x52	ot_on	0	1.62	No	No	No	No	6	8
378	1x40	1x44	ot_on	0	1.59	No	No	No	No	4	4
379	4x46	4x49	ot_on	0	1.59	No	No	No	No	7	7
380	6x33	6x34	ot_on	0	1.59	No	No	No	No	8	7
381	1x47	2x54	ot_on	0	1.58	No	No	No	No	6	7
382	2x49	3x42	ot_on	0	1.58	No	No	No	No	8	8
383	1x28	1x32	ot_on	0	1.56	No	No	No	No	5	5
384	1x42	7x42	ot_on	0	1.55	No	No	No	No	7	7
385	3x55	3x56	ot_on	0	1.53	No	No	No	No	7	5
386	5x52	5x56	ot_on	0	1.52	No	No	No	No	3	4
387	1x31	7x32	ot_on	0	1.5	No	No	No	No	5	2
388	4x51	4x55	ot_on	0	1.49	No	No	No	No	4	3
389	5x45	5x49	ot_on	0	1.49	No	No	No	No	5	5
390	2x44	2x48	ot_on	0	1.45	No	No	No	No	6	6
391	7x36	7x40	ot_on	0	1.43	No	No	No	No	5	7
392	1x32	2x67	ot_on	0	1.39	No	No	No	No	5	4
393	1x44	1x45	ot_on	0	1.38	No	No	No	No	4	5
394	7x30	Lig	ot_on	0	1.33	No	No	Yes	Yes	4	0
395	4x40	4x44	ot_on	0	1.21	No	No	No	No	5	3

Orange: nodes, hubs and links specific of ot_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of ot_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	ot_off Avg Int. Strength	ot_on Avg Int. Strength	ot_off Num Of Links	ot_on Num Of Links	ConSurf
1	1x57	ot_off	2.7575	0	4	0	7
2	I1x51	ot_off	7.62833	0	6	0	7
3	2x38	ot_off	6.7925	6.39333	4	3	7
4	2x39	ot_off	5.372	2.43	5	1	8
5	2x41	ot_off	6.47	6.34333	4	3	5
6	3x29	ot_off	8.646	6.78	5	2	4
7	3x33	ot_off	8.8625	8.245	4	2	5
8	3x44	ot_off	4.945	10.43	4	1	7
9	3x46	ot_off	4.495	7.945	4	2	8
10	3x49	ot_off	8.975	8.95	4	2	9
11	3x50	ot_off	7.615	3.785	6	2	9
12	3x54	ot_off	4.714	2.94	5	1	8
13	4x50	ot_off	4.4075	4.01333	4	3	9
14	4x64	ot_off	7.535	3.245	4	2	5
15	4x65	ot_off	8.408	9.43	5	2	6
16	E2.L177	ot_off	5.0875	13.9	4	2	4
17	E2.F191	ot_off	9.665	10.43	4	3	6
18	5x34	ot_off	5.48	6.59333	4	3	2
19	5x39	ot_off	7.014	9.02667	5	3	7
20	5x61	ot_off	5.305	3.925	4	2	8
21	6x41	ot_off	6.06	1.62	4	2	8
22	7x34	ot_off	3.1975	6.565	4	2	4
23	7x56	ot_off	7.765	5.92	4	3	7
24	2x42	Shared	5.935	7.7275	6	4	8
25	2x50	Shared	4.6725	7.5325	4	4	9
26	2x56	Shared	12.8925	12.5925	4	4	7
27	E1x50	Shared	5.8375	4.9	4	4	7
28	3x37	Shared	6.442	6.92	5	4	6
29	4x61	Shared	7.57	9.7375	5	4	6
30	5x58	Shared	8.3925	6.76167	4	6	9
31	6x40	Shared	5.14	6.34	4	4	8
32	6x48	Shared	8.15286	8.06167	7	6	8
33	6x51	Shared	8.14	6.715	5	4	7
34	6x52	Shared	8.212	7.495	5	4	7
35	7x53	Shared	7.5775	5.9475	4	4	9
36	Lig	Shared	10.888	10.6824	10	17	0
37	2x45	ot_on	9.05667	6.8175	3	4	9
38	2x60	ot_on	5.96	9.14	2	4	7
39	3x30	ot_on	5.67667	6.2275	3	4	7
40	3x32	ot_on	11.9933	7.49167	3	6	7
41	5x47	ot_on	10.04	3.8075	2	4	8
42	5x57	ot_on	6.02	3.458	2	5	6

Orange: nodes, hubs and links specific of ot_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of ot_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	ot_off Recurrence	ot_on Recurrence	ot_off Hub1?	ot_on Hub1?	ot_off Hub2?	ot_on Hub2?	ConSurf1	ConSurf2
1	1x35	1x39	ot_off	20.4148	0	No	No	No	No	5	6
2	1x35	7x35	ot_off	14.7045	0.0509476	No	No	No	No	5	4
3	7x35	7x39	ot_off	13.2696	0	No	No	No	No	4	5
4	1x38	7x39	ot_off	11.8166	0	No	No	No	No	4	5
5	1x39	7x38	ot_off	26.0089	0	No	No	No	No	6	6
6	2x60	7x38	ot_off	27.2113	0	No	Yes	No	No	7	6
7	2x56	2x60	ot_off	28.5989	0	Yes	Yes	No	Yes	7	7
8	6x48	Lig	ot_off	88.5866	0	Yes	Yes	Yes	Yes	8	0
9	7x45	7x49	ot_off	96.847	0	No	No	No	No	9	9
10	6x40	7x49	ot_off	39.1514	0	Yes	Yes	No	No	8	9
11	1x53	7x53	ot_off	14.7481	0	No	No	Yes	Yes	9	9
12	2x50	7x49	ot_off	58.6908	0	Yes	Yes	No	No	9	9
13	2x46	3x46	ot_off	59.3156	0	No	No	Yes	No	9	8
14	2x39	3x46	ot_off	21.3884	0	Yes	No	Yes	No	8	8
15	2x39	3x50	ot_off	34.7742	1.69146	Yes	No	Yes	No	8	9
16	3x50	I1x51	ot_off	17.6468	0	Yes	No	Yes	No	9	7
17	2x43	7x53	ot_off	22.4418	1.74241	No	No	Yes	Yes	7	9
18	2x39	2x43	ot_off	21.9478	0	Yes	No	No	No	8	7
19	3x46	6x37	ot_off	20.2296	0	Yes	No	No	No	8	8
20	3x50	6x37	ot_off	29.2019	0	Yes	No	No	No	9	8
21	I1x51	I2.L148	ot_off	14.2359	0	Yes	No	No	No	7	5
22	2x41	2x42	ot_off	10.8177	7.31608	Yes	No	Yes	Yes	5	8
23	3x34	4x57	ot_off	12.4923	2.04809	No	No	No	No	6	7
24	3x29	E2x50	ot_off	62.7193	0	Yes	No	No	No	4	9
25	E1x50	E2x50	ot_off	32.7509	0	Yes	Yes	No	No	7	9
26	E1x50	E2.L177	ot_off	27.9887	0	Yes	Yes	Yes	No	7	4
27	3x22	E2.L177	ot_off	42.7731	6.10353	No	No	Yes	No	4	4
28	3x22	E2.S176	ot_off	32.2533	0	No	No	No	No	4	5
29	E2.R178	E2.S176	ot_off	29.6051	0	No	No	No	No	3	5
30	E2.R178	E2x51	ot_off	24.2871	6.04239	No	No	No	No	3	3
31	E2.D186	E2x51	ot_off	21.6172	0	No	No	No	No	4	3
32	E2.D186	E2.V180	ot_off	18.94	0	No	No	No	No	4	3
33	E2.A181	E2.V180	ot_off	16.2556	0	No	No	No	No	3	3
34	E2.A181	E2.V184	ot_off	13.5639	0	No	No	No	No	3	3
35	E1x49	E2.V184	ot_off	10.8649	2.01753	No	No	No	No	5	3
36	3x29	Lig	ot_off	52.9478	0	Yes	No	Yes	Yes	4	0
37	3x25	E2x50	ot_off	29.0058	2.01753	No	No	No	No	9	9
38	3x25	E2.L177	ot_off	27.7635	0	No	No	Yes	No	9	4
39	3x33	3x37	ot_off	21.8969	0	Yes	No	Yes	Yes	5	6
40	4x61	5x39	ot_off	16.2774	0.774404	Yes	Yes	Yes	No	6	7
41	3x37	3x41	ot_off	22.489	4.04524	Yes	Yes	No	No	6	6
42	3x41	3x44	ot_off	20.7527	0	No	No	Yes	No	6	7
43	3x44	5x54	ot_off	21.9151	0	Yes	No	No	No	7	8
44	5x58	6x41	ot_off	12.7974	0	Yes	Yes	Yes	No	9	8
45	3x50	6x34	ot_off	44.4005	0	Yes	No	No	No	9	7
46	5x61	6x34	ot_off	14.047	0	Yes	No	No	No	8	7
47	3x54	6x34	ot_off	28.2829	0	Yes	No	No	No	8	7
48	3x54	6x30	ot_off	12.1109	0	Yes	No	No	No	8	8
49	4x61	4x64	ot_off	10.7523	0	Yes	Yes	Yes	No	6	5
50	4x64	4x65	ot_off	10.9412	0	Yes	No	Yes	No	5	6
51	4x64	E2.F191	ot_off	18.2753	4.086	Yes	No	Yes	No	5	6
52	5x39	E2.F191	ot_off	11.9256	0	Yes	No	Yes	No	7	6
53	E2.F185	E2.L177	ot_off	10.8649	4.086	No	No	Yes	No	3	4
54	5x35	E2.F191	ot_off	22.8595	0	No	No	Yes	No	4	6
55	5x34	5x35	ot_off	19.0853	0	Yes	No	No	No	2	4
56	5x44	6x52	ot_off	14.541	6.04239	No	No	Yes	Yes	5	7
57	6x55	Lig	ot_off	12.5686	9.80232	No	No	Yes	Yes	6	0
58	6x55	7x34	ot_off	18.8928	0	No	No	Yes	No	6	4
59	6x54	7x37	ot_off	11.6132	2.00734	No	No	No	No	5	5
60	4x41	I2.L148	ot_off	12.8228	0	No	No	No	No	7	5
61	5x54	6x41	ot_off	12.3397	0	No	No	Yes	No	8	8
62	2x56	Lig	Shared	31.6394	25.3821	Yes	Yes	Yes	Yes	7	0
63	6x48	7x45	Shared	100	11.718	Yes	Yes	No	No	8	9
64	6x40	7x53	Shared	31.2616	60.9028	Yes	Yes	Yes	Yes	8	9
65	2x46	2x50	Shared	57.256	29.6413	No	No	Yes	Yes	9	9
66	2x42	3x46	Shared	28.8895	18.3513	Yes	Yes	Yes	No	8	8
67	4x61	Lig	Shared	31.7701	45.4453	Yes	Yes	Yes	Yes	6	0
68	3x33	4x61	Shared	21.9441	24.8523	Yes	No	Yes	Yes	5	6
69	3x33	4x57	Shared	14.0216	23.3442	Yes	No	No	No	5	7
70	6x54	7x34	Shared	13.5167	13.6336	No	No	Yes	No	5	4
71	5x58	6x37	Shared	18.1845	15.7224	Yes	Yes	No	No	9	8
72	1x35	Lig	ot_on	0	11.8504	No	No	Yes	Yes	5	0
73	7x39	Lig	ot_on	0	11.5345	No	No	Yes	Yes	5	0
74	1x42	7x42	ot_on	0	13.7559	No	No	No	No	7	7
75	2x56	7x42	ot_on	7.47939	24.7605	Yes	Yes	No	No	7	7
76	1x42	7x47	ot_on	5.93556	11.8504	No	No	No	No	7	7
77	7x49	7x50	ot_on	0	41.1963	No	No	No	No	9	9
78	7x49	7x53	ot_on	0	44.1003	No	No	Yes	Yes	9	9
79	5x54	6x40	ot_on	0	55.9201	No	No	Yes	Yes	8	8
80	5x54	6x44	ot_on	0	90.2996	No	No	No	No	8	9
81	6x44	6x48	ot_on	2.61906	87.365	No	No	Yes	Yes	9	8
82	6x48	6x52	ot_on	9.80057	93.3768	Yes	Yes	Yes	Yes	8	7
83	6x51	6x52	ot_on	4.51524	100	Yes	Yes	Yes	Yes	7	7
84	6x51	Lig	ot_on	4.50797	98.9403	Yes	Yes	Yes	Yes	7	0
85	2x50	7x50	ot_on	0	35.9588	Yes	Yes	No	No	9	9
86	3x46	7x53	ot_on	0	19.9307	Yes	No	Yes	Yes	8	9
87	2x45	3x42	ot_on	0	24.353	No	Yes	No	No	9	8
88	2x46	3x42	ot_on	0	27.9091	No	No	No	No	9	8
89	2x45	4x50	ot_on	7.38494	15.4269	No	Yes	Yes	No	9	9
90	3x24	E1x50	ot_on	0	17.0776	No	No	Yes	Yes	5	7
91	3x24	3x28	ot_on	0	22.6513	No	No	No	No	5	6
92	3x28	3x32	ot_on	0	23.8639	No	No	No	Yes	6	7
93	3x32	Lig	ot_on	0.995314	25.7591	No	Yes	Yes	Yes	7	0
94	3x26	4x62	ot_on	2.7244	10.0774	No	No	No	No	6	5
95	3x30	4x62	ot_on	0	12.0338	No	Yes	No	No	7	5
96	3x30	4x57	ot_on	0	19.6556	No	Yes	No	No	7	7
97	3x47	5x57	ot_on	0	19.4314	No	No	No	Yes	8	6
98	3x47	5x58	ot_on	9.25569	20.9497	No	No	Yes	Yes	8	9
99	5x54	5x58	ot_on	0	33.7477	No	No	Yes	Yes	8	9
100	4x61	4x65	ot_on	5.9174	23.3442	Yes	Yes	Yes	No	6	6
101	E2.F191	E2x52	ot_on	0	19.6556	Yes	No	No	No	6	5
102	4x65	E2x52	ot_on	1.31134	21.5101	Yes	No	No	No	6	5
103	5x36	E2.F191	ot_on	3.80689	13.9698	No	No	Yes	No	5	6
104	5x35	E2.Q193	ot_on	0	10.0774	No	No	No	No	4	0
105	5x35	5x36	ot_on	0.0181627	12.0338	No	No	No	No	4	5
106	5x47	6x48	ot_on	0	13.8272	No	Yes	Yes	Yes	8	8
107	5x62	6x37	ot_on	0	13.8272	No	No	No	No	5	8
108	6x58	7x34	ot_on	1.94341	15.2028	No	No	Yes	No	5	4
109	6x58	Lig	ot_on	0	20.43	No	No	Yes	Yes	5	0
110	5x58	6x40	ot_on	0	10.9028	Yes	Yes	Yes	Yes	9	8

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
1x35	1x39	ot_off	3.98	0	0	1	1	2
1x35	2x64	ot_off	12.99	0	0	1	1	2
2x56	2x60	ot_off	5.12	0	1	1	1	1
2x56	3x32	Shared	11.52	7.68	1	1	1	1
2x56	7x42	Shared	4.33	7.22	1	1	1	2
2x56	Lig	Shared	30.6	19.16	1	1	1	0
2x60	7x38	ot_off	6.8	0	0	1	1	1
3x29	3x32	Shared	8.14	9.49	1	1	1	1
3x29	4x65	ot_off	17.37	0	1	1	1	1
3x29	E2x50	ot_off	6.47	0	1	1	1	2
3x29	Lig	ot_off	9.73	0	1	1	1	0
3x32	Lig	Shared	16.32	5.64	1	1	1	0
3x33	4x61	Shared	14.64	10.03	0	0	2	1
3x33	5x43	ot_off	5.71	0	0	0	2	1
3x36	6x48	ot_off	5.82	0	1	0	1	1
3x36	6x52	ot_off	3.73	0	1	0	1	2
3x36	Lig	ot_off	8.67	0	1	0	1	0
3x40	6x44	Shared	7.78	3.89	0	1	2	2
4x61	4x64	ot_off	5.49	0	1	1	1	2
4x61	4x65	Shared	5.86	10.54	1	1	1	1
4x61	5x39	Shared	6.76	10.15	1	1	1	1
4x61	Lig	Shared	5.1	8.23	1	1	1	0
4x64	4x65	ot_off	6.28	0	1	0	2	1
4x64	E2.F191	Shared	6.28	2.51	1	0	2	2
4x64	5x39	ot_off	12.09	0	1	0	2	1
4x65	E2x52	Shared	6.93	8.32	1	0	1	2
4x65	Lig	ot_off	5.6	0	1	0	1	0
E2.D186	E2x51	ot_off	11.17	0	0	0	2	1
5x39	E2.F191	ot_off	6.19	0	1	1	1	2
5x39	5x43	Shared	7.25	13.3	1	1	1	1
5x40	6x59	Shared	10.75	9.22	0	0	1	2
5x40	Lig	ot_off	5.47	0	0	0	1	0
5x42	5x43	Shared	7.05	3.52	0	0	2	1
5x461	6x52	Shared	3.93	5.24	0	1	2	2
6x44	6x48	Shared	10.02	15.03	0	1	2	1
6x48	6x51	ot_off	4.01	0	1	1	1	1
6x48	6x52	Shared	8.02	6.01	1	1	1	2
6x48	7x41	ot_off	7.78	0	1	1	1	2
6x48	7x45	Shared	13.56	14.69	1	1	1	2
6x48	Lig	ot_off	7.86	0	1	1	1	0
6x51	6x52	Shared	15	9.65	1	1	1	2
6x51	6x55	ot_off	8.2	0	1	1	1	1
6x51	7x41	Shared	4.16	8.32	1	1	1	2
6x51	Lig	Shared	9.33	5.16	1	1	1	0
6x55	Lig	Shared	10.2	16.73	1	1	1	0
6x58	7x34	Shared	3.96	2.64	0	1	1	2
7x35	7x39	ot_off	4.28	0	0	1	1	1
2x59	3x28	Shared	3.53	3.53	0	1	2	2
6x55	7x34	ot_off	3.51	0	1	1	1	2
1x38	7x39	ot_off	2.98	0	0	0	2	1
1x39	7x38	ot_off	2.83	0	0	0	2	1
4x60	5x39	ot_off	2.78	0	0	0	2	1
1x35	7x35	Shared	2.73	4.1	0	1	1	1
E2.R178	E2x51	Shared	2	6	0	0	2	1
7x30	E3.P305	ot_off	1.57	0	0	0	1	2
3x28	3x29	ot_off	1.52	0	0	1	2	1
7x38	Lig	ot_on	0	3.3	0	1	1	0
7x39	Lig	ot_on	0	5.04	0	1	1	0
2x60	Lig	ot_on	0	14.65	0	1	1	0
5x39	Lig	ot_on	0	3.63	1	1	1	0
5x43	Lig	ot_on	0	4.42	0	1	1	0
6x58	Lig	ot_on	0	7.22	0	1	1	0
E2x51	Lig	ot_on	0	13.56	0	1	1	0
7x35	Lig	ot_on	0	7.84	0	1	1	0
1x35	Lig	ot_on	0	9.91	0	1	1	0
1x31	1x35	ot_on	0	6.63	0	0	2	1
2x56	3x36	ot_on	0	16.31	1	1	1	1
2x59	2x60	ot_on	0	6.32	0	1	2	1
2x59	3x32	ot_on	0	6.32	0	1	2	1
2x60	3x29	ot_on	0	4.07	0	1	1	1
2x60	3x32	ot_on	0	11.52	0	1	1	1
2x64	7x39	ot_on	0	4.07	0	0	2	1
3x28	3x32	ot_on	0	4.3	0	1	2	1
3x40	6x48	ot_on	0	4.85	0	1	2	1
5x40	6x55	ot_on	0	6.86	0	0	1	1
5x461	6x48	ot_on	0	4.9	0	1	2	1
6x51	7x38	ot_on	0	3.73	1	1	1	1
6x58	7x29	ot_on	0	4.59	0	1	1	2
5x47	6x48	ot_on	0	2.89	0	1	2	1
E2.F191	E2x52	ot_on	0	2.77	1	0	2	2
1x39	2x64	ot_on	0	2.71	0	0	2	2
7x30	Lig	ot_on	0	1.33	0	0	1	0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	ot_off	6TPK-OT-Retosiban
	ot_on	7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2

Network Difference
Value	ot_off	ot_on
I_min	3.71	3.26
Number of Linked Nodes	239	237
Number of Specific Nodes	23 (9.62%)	21 (8.86%)
Number of Shared Nodes	216 (90.38%)	216 (91.14%)
Number of Links	269	243
Number of Specific Links	152 (56.51%)	126 (51.85%)
Number of Shared Links	117 (43.49%)	117 (48.15%)
Number of Hubs	36	19
Number of Specific Hubs	23 (63.89%)	6 (31.58%)
Number of Shared Hubs	13 (36.11%)	13 (68.42%)
Average % Shared Neighbours (Jaccard)	32.30
Average % Shared Neighbours (Otsuka)	41.29
Average % Shared Neighbours (Overlap Coefficient)	50.83
Average % Shared Cliques (k3-6)	75.64
Graphlets Similarity	0.572226

Paths Difference
Value	ot_off	ot_on
Number Of Nodes in MetaPath	68	49
Specific Nodes in MetaPath	42 (61.76%)	23 (46.94%)
Shared Nodes in MetaPath	216 (90.38%)	216 (90.38%)
Number Of Links MetaPath	71	49
Specific Links in MetaPath	61 (85.92%)	39 (79.59%)
Shared Links in MetaPath	117 (43.49%)	117 (43.49%)
Number of Shortest Paths	55617	19318
Length Of Smallest Path	3	3
Average Path Length	13.6516	11.548
Length of Longest Path	30	29
Minimum Path Strength	1.46	1.38
Average Path Strength	7.01631	6.72118
Maximum Path Strength	18.31	19.79
Minimum Path Correlation	0.7	0.7
Average Path Correlation	0.912031	0.909872
Maximum Path Correlation	0.99	0.99
Minimum % Of Corr. Nodes	4	5
Average % Of Corr. Nodes	39.2088	47.4382
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	45.2043	39.0629
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download ot_off_on.zip<

You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.

You can also read or download a guide explaining the meaning of all files and numerical data.