psnGPCR

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Orange: nodes, hubs and links specific of ox2_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of ox2_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	ox2_off Int. Strength	ox2_on Int. Strength	ox2_off Hub1?	ox2_on Hub1?	ox2_off Hub2?	ox2_on Hub2?	ConSurf1	ConSurf2
1	NT.F39	NT.L43	ox2_off	100	0	No	No	No	No	5	8
2	NT.E46	NT.Y42	ox2_off	100	0	No	No	No	No	7	4
3	NT.L48	NT.Y47	ox2_off	100	0	No	No	No	No	4	5
4	1x31	NT.K51	ox2_off	100	0	Yes	No	Yes	No	4	4
5	2x67	NT.K51	ox2_off	100	0	No	No	Yes	No	4	4
6	1x35	1x39	ox2_off	100	0	No	No	Yes	Yes	5	7
7	1x36	2x65	ox2_off	100	0	No	No	No	No	5	5
8	1x39	2x60	ox2_off	100	0	Yes	Yes	Yes	No	7	7
9	1x43	2x54	ox2_off	100	0	No	No	No	No	6	7
10	1x49	7x50	ox2_off	100	0	No	No	No	No	8	9
11	1x53	7x50	ox2_off	100	0	No	No	No	No	9	9
12	1x54	1x58	ox2_off	100	0	No	No	No	No	6	3
13	1x55	1x59	ox2_off	100	0	No	No	No	No	5	6
14	8x49	I1x50	ox2_off	100	0	No	No	Yes	Yes	7	8
15	2x41	I1x51	ox2_off	100	0	No	No	No	No	4	8
16	2x38	3x49	ox2_off	100	0	No	No	No	No	6	9
17	2x39	3x50	ox2_off	100	0	No	No	Yes	No	8	9
18	2x40	8x50	ox2_off	100	0	No	No	Yes	Yes	9	8
19	2x42	3x42	ox2_off	100	0	Yes	Yes	No	No	8	7
20	2x42	4x46	ox2_off	100	0	Yes	Yes	No	No	8	8
21	2x43	7x53	ox2_off	100	0	No	No	Yes	Yes	8	9
22	2x52	2x551	ox2_off	100	0	No	No	Yes	No	6	5
23	2x53	3x32	ox2_off	100	0	Yes	No	Yes	Yes	7	7
24	2x53	7x42	ox2_off	100	0	Yes	No	Yes	Yes	7	7
25	2x551	3x31	ox2_off	100	0	Yes	No	No	No	5	5
26	2x59	E1x52	ox2_off	100	0	No	No	No	No	4	6
27	2x60	2x64	ox2_off	100	0	Yes	No	No	No	7	5
28	2x61	2x65	ox2_off	100	0	No	No	No	No	6	5
29	2x62	E1x52	ox2_off	100	0	No	No	No	No	4	6
30	2x64	7x38	ox2_off	100	0	No	No	Yes	Yes	5	5
31	2x66	E1x51	ox2_off	100	0	Yes	No	No	No	5	4
32	2x67	7x27	ox2_off	100	0	No	No	Yes	No	4	1
33	3x28	E1x50	ox2_off	100	0	No	No	Yes	Yes	5	7
34	3x26	E2.E192	ox2_off	100	0	No	No	No	No	6	5
35	3x32	7x42	ox2_off	100	0	Yes	Yes	Yes	Yes	7	7
36	3x33	5x43	ox2_off	100	0	No	No	Yes	No	6	5
37	3x34	4x57	ox2_off	100	0	No	No	Yes	No	5	7
38	3x36	6x48	ox2_off	100	0	No	No	Yes	Yes	6	7
39	3x38	4x49	ox2_off	100	0	No	No	No	No	7	6
40	3x42	4x49	ox2_off	100	0	No	No	No	No	7	6
41	3x44	5x54	ox2_off	100	0	No	No	No	No	7	8
42	3x46	6x37	ox2_off	100	0	No	No	Yes	No	8	8
43	3x47	5x54	ox2_off	100	0	No	No	No	No	8	8
44	3x48	3x52	ox2_off	100	0	No	No	Yes	No	6	4
45	3x49	3x50	ox2_off	100	0	No	No	Yes	No	9	9
46	3x50	3x53	ox2_off	100	0	Yes	No	No	No	9	8
47	3x52	3x56	ox2_off	100	0	Yes	No	Yes	No	4	6
48	3x52	I2x53	ox2_off	100	0	Yes	No	Yes	No	4	7
49	3x54	5x65	ox2_off	100	0	No	No	No	No	8	8
50	3x54	6x30	ox2_off	100	0	No	No	No	No	8	8
51	3x56	I2x51	ox2_off	100	0	Yes	No	No	No	6	7
52	4x41	I2x53	ox2_off	100	0	No	No	Yes	No	7	7
53	E2.F197	E2.K203	ox2_off	100	0	Yes	No	No	No	2	3
54	5x39	5x43	ox2_off	100	0	Yes	Yes	Yes	No	8	5
55	5x40	6x55	ox2_off	100	0	Yes	No	No	No	6	7
56	5x58	6x38	ox2_off	100	0	Yes	Yes	No	Yes	9	6
57	5x63	5x67	ox2_off	100	0	No	No	No	No	4	5
58	5x63	5x68	ox2_off	100	0	No	No	No	No	4	7
59	5x65	5x66	ox2_off	100	0	No	No	Yes	No	8	5
60	5x66	6x35	ox2_off	100	0	Yes	No	No	No	5	8
61	6x35	7x56	ox2_off	100	0	No	No	No	No	8	7
62	6x36	7x53	ox2_off	100	0	No	No	Yes	Yes	8	9
63	6x39	7x52	ox2_off	100	0	No	No	No	No	6	8
64	6x39	7x56	ox2_off	100	0	No	No	No	No	6	7
65	6x40	7x49	ox2_off	100	0	No	No	No	Yes	8	9
66	6x44	7x45	ox2_off	100	0	Yes	Yes	Yes	No	9	9
67	6x47	7x40	ox2_off	100	0	No	No	Yes	No	8	8
68	7x34	7x38	ox2_off	100	0	Yes	Yes	Yes	Yes	4	5
69	7x39	7x40	ox2_off	100	0	Yes	Yes	Yes	No	5	8
70	7x49	7x53	ox2_off	100	0	No	Yes	Yes	Yes	9	9
71	7x53	8x50	ox2_off	100	0	Yes	Yes	Yes	Yes	9	8
72	7x54	8x51	ox2_off	100	0	No	No	No	No	7	8
73	7x54	8x54	ox2_off	100	0	No	No	Yes	Yes	7	7
74	8x50	8x54	ox2_off	100	0	Yes	Yes	Yes	Yes	8	7
75	8x61	8x62	ox2_off	100	0	No	No	No	No	3	1
76	E2.T208	NT.E38	ox2_off	100	0	No	No	No	No	3	0
77	2x66	NT.Y42	ox2_off	100	0	Yes	No	No	No	5	4
78	E2.F207	NT.R45	ox2_off	100	0	Yes	No	No	No	3	6
79	3x56	I2x53	ox2_off	100	0	Yes	No	Yes	No	6	7
80	I2x51	I2x53	ox2_off	100	0	No	No	Yes	No	7	7
81	NT.D33	NT.D35	ox2_off	100	0	No	No	No	No	0	0
82	NT.E37	NT.L40	ox2_off	100	0	No	No	No	No	0	4
83	5x69	6x27	ox2_off	100	0	No	No	No	No	5	4
84	1x56	8x53	ox2_off	25	0	No	No	No	No	8	7
85	1x45	7x47	ox2_off	50	0	No	No	No	No	5	5
86	2x38	4x42	ox2_off	50	0	No	No	No	No	6	7
87	5x64	5x69	ox2_off	50	0	No	No	No	No	5	5
88	2x46	3x39	ox2_off	25	0	No	Yes	No	No	9	9
89	E2.R213	E2.S194	ox2_off	25	0	No	No	No	No	4	3
90	E1x51	NT.E38	ox2_off	50	0	No	No	No	No	4	0
91	3x37	4x56	ox2_off	50	0	No	No	Yes	No	7	5
92	1x58	2x44	ox2_off	50	0	No	No	No	No	3	6
93	1x52	8x58	ox2_off	50	0	Yes	No	No	No	6	5
94	3x27	3x31	ox2_off	0	0	No	No	No	No	4	5
95	1x53	8x54	ox2_off	25	0	No	No	Yes	Yes	9	7
96	2x39	6x37	ox2_off	25	0	No	No	Yes	No	8	8
97	E2.F207	E2.V209	ox2_off	25	0	Yes	No	No	No	3	5
98	E2.F207	E2.P198	ox2_off	50	0	Yes	No	No	No	3	2
99	6x20	6x23	ox2_off	25	0	No	No	No	No	0	0
100	6x53	6x57	ox2_off	0	0	No	No	No	No	5	5
101	8x51	8x55	ox2_off	50	0	No	No	No	No	8	5
102	1x52	8x57	ox2_off	25	0	Yes	No	No	No	6	6
103	1x44	1x48	ox2_off	0	0	No	No	No	No	4	4
104	2x51	2x55	ox2_off	0	0	No	No	No	No	7	4
105	1x31	7x32	ox2_off	50	0	Yes	No	No	No	4	1
106	2x55	2x551	ox2_off	0	0	No	No	Yes	No	4	5
107	8x60	CT.H388	ox2_off	25	0	No	No	No	No	9	0
108	E2.F197	E2.T195	ox2_off	25	0	Yes	No	No	No	2	2
109	2x49	4x50	ox2_off	0	0	No	No	No	No	8	9
110	5x66	6x34	ox2_off	0	0	Yes	No	No	No	5	7
111	4x59	4x63	ox2_off	0	0	No	No	No	No	5	5
112	NT.L48	NT.W44	ox2_off	25	0	No	No	No	No	4	7
113	7x27	NT.H49	ox2_off	25	0	Yes	No	No	No	1	4
114	1x32	NT.E46	ox2_off	25	0	No	No	No	No	7	7
115	NT.E37	NT.Y34	ox2_off	25	0	No	No	No	No	0	0
116	6x30	I2x52	ox2_off	50	0	No	No	No	No	8	5
117	3x55	5x61	ox2_off	25	0	No	No	No	No	7	9
118	2x63	E1x50	ox2_off	0	0	No	No	Yes	Yes	5	7
119	8x59	CT.H387	ox2_off	25	0	No	No	No	No	4	0
120	8x60	CT.H387	ox2_off	25	0	No	No	No	No	9	0
121	NT.E46	NT.K51	ox2_off	25	0	No	No	Yes	No	7	4
122	NT.E38	NT.R41	ox2_off	25	0	No	No	No	No	0	5
123	E2.T205	NT.R45	ox2_off	50	0	No	No	No	No	3	6
124	7x27	E3.T336	ox2_off	25	0	Yes	No	No	No	1	4
125	5x51	5x55	ox2_off	0	0	No	No	No	No	6	5
126	6x28	6x32	ox2_off	25	0	No	No	No	No	5	8
127	2x41	4x39	ox2_off	25	0	No	No	No	No	4	3
128	1x42	7x47	ox2_off	0	0	No	No	No	No	7	5
129	7x54	7x55	ox2_off	50	0	No	No	No	No	7	5
130	E2.A206	E2.F197	ox2_off	50	0	No	No	Yes	No	0	2
131	5x71	6x23	ox2_off	25	0	Yes	No	No	No	0	0
132	E2.T204	E2.T205	ox2_off	25	0	No	No	No	No	3	3
133	1x31	1x34	ox2_off	25	0	Yes	No	No	No	4	6
134	8x63	CT.V386	ox2_off	25	0	No	No	No	No	0	0
135	NT.F39	NT.Y42	ox2_off	0	0	No	No	No	No	5	4
136	5x53	5x57	ox2_off	25	0	No	No	No	No	7	5
137	4x40	4x43	ox2_off	25	0	No	No	No	No	5	4
138	8x59	CT.V386	ox2_off	0	0	No	No	No	No	4	0
139	NT.H49	NT.L48	ox2_off	25	0	No	No	No	No	4	4
140	8x58	8x62	ox2_off	25	0	No	No	No	No	5	1
141	1x51	1x55	ox2_off	0	0	No	No	No	No	4	5
142	6x54	7x33	ox2_off	0	0	No	No	No	No	5	5
143	4x39	4x43	ox2_off	25	0	No	No	No	No	3	4
144	5x35	5x38	ox2_off	25	0	No	No	No	No	3	4
145	NT.D36	NT.E37	ox2_off	25	0	No	No	No	No	0	0
146	7x26	E3.E337	ox2_off	0	0	No	No	No	No	3	2
147	6x43	7x48	ox2_off	0	0	No	No	No	No	6	6
148	NT.T32	NT.Y34	ox2_off	25	0	No	No	No	No	0	0
149	3x50	I2.K163	ox2_off	25	0	Yes	No	No	No	9	5
150	8x60	8x61	ox2_off	0	0	No	No	No	No	9	3
151	1x41	1x45	ox2_off	0	0	No	No	No	No	3	5
152	8x53	8x56	ox2_off	0	0	No	No	No	No	7	4
153	1x31	NT.E52	ox2_off	25	0	Yes	No	No	No	4	3
154	5x37	E2.E217	ox2_off	0	0	No	No	No	No	4	3
155	7x26	7x28	ox2_off	0	0	No	No	No	No	3	1
156	5x70	6x31	ox2_off	25	0	No	No	No	No	0	5
157	8x63	CT.G385	ox2_off	0	0	No	No	No	No	0	0
158	5x70	5x71	ox2_off	25	0	No	No	Yes	No	0	0
159	5x71	6x24	ox2_off	25	0	Yes	No	No	No	0	0
160	5x71	6x27	ox2_off	25	0	Yes	No	No	No	0	4
161	E3.E337	E3.H335	ox2_off	0	0	No	No	No	No	2	1
162	5x71	5x72	ox2_off	0	0	Yes	No	No	No	0	0
163	6x20	6x22	ox2_off	0	0	No	No	No	No	0	0
164	6x21	6x25	ox2_off	0	0	No	No	No	No	0	3
165	E2.A201	E2.D202	ox2_off	0	0	No	No	No	No	0	0
166	4x55	4x59	ox2_off	0	0	No	No	No	No	3	5
167	5x56	5x59	ox2_off	0	0	No	No	No	No	4	2
168	NT.L40	NT.L43	ox2_off	0	0	No	No	No	No	4	8
169	NT.D33	NT.D36	ox2_off	0	0	No	No	No	No	0	0
170	1x33	1x34	Shared	100	0	No	No	No	No	4	6
171	1x39	2x57	Shared	100	100	Yes	Yes	Yes	Yes	7	7
172	1x39	2x61	Shared	100	100	Yes	Yes	No	No	7	6
173	1x39	7x39	Shared	100	100	Yes	Yes	Yes	Yes	7	5
174	1x39	7x42	Shared	100	100	Yes	Yes	Yes	Yes	7	7
175	1x42	7x39	Shared	100	100	No	No	Yes	Yes	7	5
176	1x43	2x57	Shared	100	100	No	No	Yes	Yes	6	7
177	1x46	2x54	Shared	100	100	No	No	No	No	8	7
178	1x50	2x47	Shared	100	100	No	Yes	No	No	9	9
179	1x50	2x50	Shared	100	100	No	Yes	No	Yes	9	9
180	1x50	7x50	Shared	100	100	No	Yes	No	No	9	9
181	1x53	2x47	Shared	100	100	No	No	No	No	9	9
182	1x57	2x44	Shared	100	100	No	No	No	No	7	6
183	1x60	I1x49	Shared	100	100	No	Yes	No	No	6	5
184	1x60	I1x50	Shared	100	100	No	Yes	Yes	Yes	6	8
185	1x60	8x53	Shared	100	100	No	Yes	No	No	6	7
186	I1x48	I1x51	Shared	100	100	No	No	No	No	7	8
187	8x50	I1x50	Shared	100	100	Yes	Yes	Yes	Yes	8	8
188	2x37	2x40	Shared	100	100	No	No	No	No	7	9
189	2x42	3x45	Shared	100	100	Yes	Yes	No	No	8	6
190	2x42	3x46	Shared	100	100	Yes	Yes	No	No	8	8
191	2x42	4x45	Shared	100	100	Yes	Yes	No	No	8	6
192	2x45	3x42	Shared	100	100	No	No	No	No	9	7
193	2x45	4x46	Shared	100	100	No	No	No	No	9	8
194	2x45	4x50	Shared	100	100	No	No	No	No	9	9
195	2x46	3x43	Shared	100	100	No	Yes	No	Yes	9	9
196	2x50	7x46	Shared	100	100	No	Yes	No	No	9	9
197	2x53	2x56	Shared	100	100	Yes	No	Yes	Yes	7	7
198	2x53	3x35	Shared	100	100	Yes	No	No	No	7	5
199	2x551	2x56	Shared	100	0	Yes	No	Yes	Yes	5	7
200	2x56	3x32	Shared	100	100	Yes	Yes	Yes	Yes	7	7
201	2x56	7x42	Shared	100	100	Yes	Yes	Yes	Yes	7	7
202	2x57	2x58	Shared	100	66.6667	Yes	Yes	No	No	7	8
203	2x57	7x42	Shared	100	100	Yes	Yes	Yes	Yes	7	7
204	2x60	7x38	Shared	100	100	Yes	No	Yes	Yes	7	5
205	2x60	7x42	Shared	100	100	Yes	No	Yes	Yes	7	7
206	2x60	Lig	Shared	100	100	Yes	No	Yes	Yes	7	0
207	2x62	2x66	Shared	100	33.3333	No	No	Yes	No	4	5
208	2x64	7x35	Shared	100	100	No	No	No	No	5	4
209	2x66	E1x49	Shared	100	100	Yes	No	No	No	5	5
210	2x67	7x31	Shared	100	100	No	No	No	No	4	3
211	E1x49	E1x51	Shared	100	100	No	No	No	No	5	4
212	E1x50	E1x52	Shared	100	100	Yes	Yes	No	No	7	6
213	3x25	E1x50	Shared	100	100	No	No	Yes	Yes	9	7
214	E1x50	E2x50	Shared	100	100	Yes	Yes	No	No	7	9
215	3x22	E2.E192	Shared	100	33.3333	No	No	No	No	4	5
216	3x22	E2.C193	Shared	100	33.3333	No	No	No	No	4	4
217	3x24	3x28	Shared	100	100	No	Yes	No	No	5	5
218	3x25	E2x50	Shared	100	100	No	No	No	No	9	9
219	3x29	4x65	Shared	100	100	No	No	No	No	5	6
220	3x29	Lig	Shared	100	100	No	No	Yes	Yes	5	0
221	3x30	3x34	Shared	100	100	No	Yes	No	No	6	5
222	3x30	4x54	Shared	100	100	No	Yes	No	No	6	4
223	3x30	4x62	Shared	100	100	No	Yes	No	No	6	6
224	3x32	Lig	Shared	100	100	Yes	Yes	Yes	Yes	7	0
225	3x33	4x57	Shared	100	100	No	No	Yes	No	6	7
226	3x33	4x61	Shared	100	100	No	No	Yes	Yes	6	6
227	3x36	Lig	Shared	100	100	No	No	Yes	Yes	6	0
228	3x37	4x53	Shared	100	100	No	No	No	No	7	8
229	3x38	4x50	Shared	100	100	No	No	No	No	7	9
230	3x38	4x53	Shared	100	100	No	No	No	No	7	8
231	3x40	5x50	Shared	100	100	No	No	No	No	8	9
232	3x40	6x44	Shared	100	100	No	No	Yes	Yes	8	9
233	3x41	4x49	Shared	100	100	No	No	No	No	6	6
234	3x43	6x44	Shared	100	100	No	Yes	Yes	Yes	9	9
235	3x47	5x58	Shared	100	100	No	No	Yes	Yes	8	9
236	3x51	3x52	Shared	100	100	Yes	Yes	Yes	No	8	4
237	3x51	3x55	Shared	100	100	Yes	Yes	No	No	8	7
238	3x51	3x56	Shared	100	100	Yes	Yes	Yes	No	8	6
239	3x51	5x57	Shared	100	100	Yes	Yes	No	No	8	5
240	3x51	5x60	Shared	100	100	Yes	Yes	No	No	8	5
241	3x56	I2x50	Shared	100	0	Yes	No	No	No	6	9
242	4x56	4x57	Shared	100	100	Yes	No	Yes	No	5	7
243	4x57	5x43	Shared	100	100	Yes	No	Yes	No	7	5
244	4x60	5x39	Shared	100	100	No	No	Yes	Yes	6	8
245	4x61	E2x52	Shared	100	100	Yes	Yes	Yes	Yes	6	4
246	4x61	5x39	Shared	100	100	Yes	Yes	Yes	Yes	6	8
247	4x61	Lig	Shared	100	100	Yes	Yes	Yes	Yes	6	0
248	4x64	E2x52	Shared	100	100	No	No	Yes	Yes	6	4
249	4x64	E2.W214	Shared	100	100	No	No	Yes	Yes	6	4
250	E2.E192	E2.R213	Shared	100	100	No	No	No	No	5	4
251	E2.T195	E2.T208	Shared	100	33.3333	No	No	No	No	2	3
252	E2.F207	E2.V196	Shared	100	33.3333	Yes	No	No	No	3	3
253	6x59	E2x51	Shared	100	100	Yes	Yes	No	No	4	5
254	E2.W214	E2x52	Shared	100	100	Yes	Yes	Yes	Yes	4	4
255	5x40	E2x52	Shared	100	100	Yes	No	Yes	Yes	6	4
256	6x59	E2x52	Shared	100	100	Yes	Yes	Yes	Yes	4	4
257	5x36	E2.W214	Shared	100	100	No	No	Yes	Yes	5	4
258	5x39	E2.W214	Shared	100	100	Yes	Yes	Yes	Yes	8	4
259	5x34	5x38	Shared	100	0	No	No	No	No	4	4
260	5x39	5x40	Shared	100	100	Yes	Yes	Yes	No	8	6
261	5x40	6x59	Shared	100	100	Yes	No	Yes	Yes	6	4
262	5x41	6x60	Shared	100	0	No	No	No	Yes	5	5
263	5x43	5x461	Shared	100	100	Yes	No	No	No	5	6
264	5x43	Lig	Shared	100	100	Yes	No	Yes	Yes	5	0
265	5x44	5x47	Shared	100	100	Yes	Yes	Yes	Yes	6	8
266	5x44	5x48	Shared	100	100	Yes	Yes	No	No	6	5
267	5x44	6x52	Shared	100	100	Yes	Yes	No	No	6	6
268	5x44	6x56	Shared	100	100	Yes	Yes	No	No	6	6
269	5x47	5x51	Shared	100	100	Yes	Yes	No	No	8	6
270	5x47	6x49	Shared	100	100	Yes	Yes	No	No	8	6
271	5x47	6x52	Shared	100	100	Yes	Yes	No	No	8	6
272	5x54	6x41	Shared	100	100	No	No	No	Yes	8	8
273	5x58	6x37	Shared	100	100	Yes	Yes	Yes	No	9	8
274	5x62	5x66	Shared	100	100	No	No	Yes	No	6	5
275	5x64	5x68	Shared	100	33.3333	No	No	No	No	5	7
276	5x66	6x31	Shared	100	100	Yes	No	No	No	5	5
277	6x25	6x28	Shared	100	33.3333	No	No	No	No	3	5
278	6x27	6x31	Shared	100	33.3333	No	No	No	No	4	5
279	6x36	7x56	Shared	100	33.3333	No	No	No	No	8	7
280	6x40	7x52	Shared	100	100	No	No	No	No	8	8
281	6x42	6x46	Shared	100	0	No	No	No	No	4	5
282	6x43	7x52	Shared	100	100	No	No	No	No	6	8
283	6x44	6x48	Shared	100	100	Yes	Yes	Yes	Yes	9	7
284	6x47	7x45	Shared	100	100	No	No	Yes	No	8	9
285	6x48	7x41	Shared	100	100	Yes	Yes	No	No	7	7
286	6x48	7x45	Shared	100	100	Yes	Yes	Yes	No	7	9
287	6x49	6x50	Shared	100	100	No	No	No	No	6	9
288	6x51	7x37	Shared	100	100	No	Yes	No	No	7	6
289	6x51	7x41	Shared	100	100	No	Yes	No	No	7	7
290	6x51	Lig	Shared	100	100	No	Yes	Yes	Yes	7	0
291	6x54	7x34	Shared	100	100	No	No	Yes	Yes	5	4
292	6x55	Lig	Shared	100	100	No	No	Yes	Yes	7	0
293	6x56	6x60	Shared	100	33.3333	No	No	No	Yes	6	5
294	6x57	E3.M332	Shared	100	33.3333	No	No	No	No	5	3
295	6x58	6x59	Shared	100	100	No	No	Yes	Yes	3	4
296	6x58	7x34	Shared	100	100	No	No	Yes	Yes	3	4
297	6x60	6x61	Shared	100	100	No	Yes	No	No	5	3
298	E3.F333	E3.M332	Shared	100	100	No	Yes	No	No	4	3
299	7x30	E3.F333	Shared	100	100	No	No	No	Yes	5	4
300	7x34	E3.F333	Shared	100	100	Yes	Yes	No	Yes	4	4
301	7x26	7x29	Shared	100	100	No	No	No	No	3	4
302	7x27	7x31	Shared	100	100	Yes	No	No	No	1	3
303	7x36	7x40	Shared	100	100	No	No	Yes	No	4	8
304	7x38	Lig	Shared	100	100	Yes	Yes	Yes	Yes	5	0
305	7x39	7x43	Shared	100	33.3333	Yes	Yes	No	No	5	4
306	7x45	7x49	Shared	100	100	Yes	No	No	Yes	9	9
307	8x47	8x50	Shared	100	33.3333	No	No	Yes	Yes	8	8
308	8x48	8x51	Shared	100	33.3333	No	No	No	No	5	8
309	3x49	I2.S164	Shared	100	100	No	No	No	No	9	5
310	6x26	6x30	Shared	100	100	No	No	No	No	4	8
311	3x28	3x29	Shared	50	100	No	No	No	No	5	5
312	4x59	4x60	Shared	50	100	No	No	No	No	5	6
313	5x58	5x61	Shared	50	0	Yes	Yes	No	No	9	9
314	6x50	7x40	Shared	50	100	No	No	Yes	No	9	8
315	E1x49	E2.F207	Shared	75	100	No	No	Yes	No	5	3
316	3x25	E2.C193	Shared	75	66.6667	No	No	No	No	9	4
317	1x54	2x48	Shared	25	0	No	No	No	No	6	5
318	5x51	6x45	Shared	0	33.3333	No	No	No	No	6	5
319	4x47	4x51	Shared	0	0	No	No	No	No	3	3
320	1x52	8x54	Shared	50	0	Yes	No	Yes	Yes	6	7
321	8x52	8x55	Shared	25	33.3333	No	No	No	No	5	5
322	6x33	6x37	Shared	0	0	No	No	Yes	No	8	8
323	4x38	4x41	Shared	25	0	No	No	No	No	5	7
324	1x47	2x55	Shared	0	33.3333	No	No	No	No	6	4
325	1x48	1x52	Shared	0	33.3333	No	No	Yes	No	4	6
326	7x51	7x55	Shared	25	33.3333	No	No	No	No	6	5
327	3x21	E1x50	Shared	0	0	No	No	Yes	Yes	8	7
328	1x58	I1x51	Shared	25	0	No	No	No	No	3	8
329	5x59	5x63	Shared	25	0	No	No	No	No	2	4
330	NT.H49	NT.P50	Shared	25	0	No	No	No	No	4	5
331	1x57	I1x50	Shared	25	0	No	No	Yes	Yes	7	8
332	5x35	E2.W214	Shared	25	33.3333	No	No	Yes	Yes	3	4
333	5x45	5x48	Shared	25	0	No	No	No	No	4	5
334	1x38	7x39	Shared	25	0	No	No	Yes	Yes	4	5
335	7x29	7x33	Shared	0	0	No	No	No	No	4	5
336	1x32	NT.K51	Shared	25	33.3333	No	No	Yes	No	7	4
337	4x52	4x56	Shared	0	0	No	No	Yes	No	5	5
338	1x36	1x40	Shared	0	0	No	No	No	No	5	3
339	4x43	4x44	Shared	25	100	No	No	No	No	4	3
340	E2.G215	E2.G216	Shared	0	0	No	No	No	No	4	5
341	1x37	1x38	Shared	0	0	No	No	No	No	4	4
342	5x49	5x50	Shared	0	0	No	No	No	No	5	9
343	6x32	6x35	Shared	25	100	No	No	No	No	8	8
344	4x51	4x55	Shared	0	0	No	No	No	No	3	3
345	1x51	2x51	Shared	0	0	No	No	No	No	4	7
346	4x48	4x52	Shared	0	0	No	No	No	No	3	5
347	4x56	5x46	Shared	0	0	Yes	No	No	No	5	4
348	E2.F197	E2.L206	Shared	25	33.3333	Yes	No	No	No	2	4
349	5x48	5x52	Shared	25	66.6667	No	No	No	No	5	4
350	E2.G215	E2.W214	Shared	0	0	No	No	Yes	Yes	4	4
351	E3.A334	E3.H335	Shared	0	33.3333	No	No	No	No	2	1
352	1x35	7x35	ox2_on	0	100	No	No	No	No	5	4
353	1x39	7x35	ox2_on	0	100	Yes	Yes	No	No	7	4
354	1x43	1x47	ox2_on	0	100	No	No	No	No	6	6
355	1x50	2x51	ox2_on	0	100	No	Yes	No	No	9	7
356	1x53	7x54	ox2_on	0	100	No	No	No	No	9	7
357	1x58	1x59	ox2_on	0	100	No	No	No	No	3	6
358	8x53	I1x50	ox2_on	0	100	No	No	Yes	Yes	7	8
359	2x38	I2.S164	ox2_on	0	100	No	No	No	No	6	5
360	2x40	2x43	ox2_on	0	100	No	No	No	No	9	8
361	2x42	4x42	ox2_on	0	100	Yes	Yes	No	No	8	7
362	2x43	7x54	ox2_on	0	100	No	No	No	No	8	7
363	2x46	2x50	ox2_on	0	100	No	Yes	No	Yes	9	9
364	2x46	3x42	ox2_on	0	100	No	Yes	No	No	9	7
365	2x46	7x49	ox2_on	0	100	No	Yes	No	Yes	9	9
366	2x50	7x49	ox2_on	0	100	No	Yes	No	Yes	9	9
367	2x52	3x35	ox2_on	0	100	No	No	No	No	6	5
368	2x53	7x46	ox2_on	0	100	Yes	No	No	No	7	9
369	2x63	Lig	ox2_on	0	100	No	No	Yes	Yes	5	0
370	3x24	E1x52	ox2_on	0	100	No	Yes	No	No	5	6
371	3x28	3x32	ox2_on	0	100	No	No	Yes	Yes	5	7
372	3x30	4x59	ox2_on	0	100	No	Yes	No	No	6	5
373	3x33	Lig	ox2_on	0	100	No	No	Yes	Yes	6	0
374	3x40	6x48	ox2_on	0	100	No	No	Yes	Yes	8	7
375	3x43	7x49	ox2_on	0	100	No	Yes	No	Yes	9	9
376	3x43	7x53	ox2_on	0	100	No	Yes	Yes	Yes	9	9
377	3x44	5x53	ox2_on	0	100	No	No	No	No	7	7
378	3x45	4x49	ox2_on	0	100	No	No	No	No	6	6
379	3x46	3x50	ox2_on	0	100	No	No	Yes	No	8	9
380	3x46	7x53	ox2_on	0	100	No	No	Yes	Yes	8	9
381	3x50	5x58	ox2_on	0	100	Yes	No	Yes	Yes	9	9
382	3x50	7x53	ox2_on	0	100	Yes	No	Yes	Yes	9	9
383	3x52	I2.K163	ox2_on	0	100	Yes	No	No	No	4	5
384	3x52	4x41	ox2_on	0	100	Yes	No	No	No	4	7
385	3x54	5x61	ox2_on	0	100	No	No	No	No	8	9
386	3x56	I2x52	ox2_on	0	100	Yes	No	No	No	6	5
387	I2.K163	I2x52	ox2_on	0	100	No	No	No	No	5	5
388	4x41	I2.K163	ox2_on	0	100	No	No	No	No	7	5
389	4x38	4x40	ox2_on	0	100	No	No	No	No	5	5
390	4x65	E2x52	ox2_on	0	100	No	No	Yes	Yes	6	4
391	E2.K203	E2.P198	ox2_on	0	100	No	No	No	No	3	2
392	5x37	6x60	ox2_on	0	100	No	No	No	Yes	4	5
393	5x51	6x44	ox2_on	0	100	No	No	Yes	Yes	6	9
394	5x54	5x58	ox2_on	0	100	No	No	Yes	Yes	8	9
395	5x54	6x44	ox2_on	0	100	No	No	Yes	Yes	8	9
396	5x55	6x41	ox2_on	0	100	No	No	No	Yes	5	8
397	5x58	6x41	ox2_on	0	100	Yes	Yes	No	Yes	9	8
398	5x62	6x34	ox2_on	0	100	No	No	No	No	6	7
399	5x62	6x38	ox2_on	0	100	No	No	No	Yes	6	6
400	5x65	6x30	ox2_on	0	100	No	No	No	No	8	8
401	5x65	6x33	ox2_on	0	100	No	No	No	No	8	8
402	6x40	7x53	ox2_on	0	100	No	No	Yes	Yes	8	9
403	6x51	7x38	ox2_on	0	100	No	Yes	Yes	Yes	7	5
404	6x58	E3.F333	ox2_on	0	100	No	No	No	Yes	3	4
405	7x30	7x34	ox2_on	0	100	No	No	Yes	Yes	5	4
406	7x31	Lig	ox2_on	0	100	No	No	Yes	Yes	3	0
407	7x36	7x39	ox2_on	0	100	No	No	Yes	Yes	4	5
408	7x38	7x42	ox2_on	0	100	Yes	Yes	Yes	Yes	5	7
409	7x41	7x42	ox2_on	0	100	No	No	Yes	Yes	7	7
410	7x52	7x53	ox2_on	0	100	No	No	Yes	Yes	8	9
411	7x54	8x50	ox2_on	0	100	No	No	Yes	Yes	7	8
412	7x55	8x50	ox2_on	0	100	No	No	Yes	Yes	5	8
413	8x49	8x53	ox2_on	0	100	No	No	No	No	7	7
414	4x40	4x44	ox2_on	0	100	No	No	No	No	5	3
415	5x461	Lig	ox2_on	0	100	No	No	Yes	Yes	6	0
416	7x27	Lig	ox2_on	0	100	Yes	No	Yes	Yes	1	0
417	2x65	2x66	ox2_on	0	33.3333	No	No	Yes	No	5	5
418	3x44	5x50	ox2_on	0	66.6667	No	No	No	No	7	9
419	1x47	2x54	ox2_on	0	0	No	No	No	No	6	7
420	E1x51	E1x52	ox2_on	0	33.3333	No	No	No	No	4	6
421	7x55	8x54	ox2_on	0	33.3333	No	No	Yes	Yes	5	7
422	2x49	3x38	ox2_on	0	66.6667	No	No	No	No	8	7
423	7x28	7x29	ox2_on	0	66.6667	No	No	No	No	1	4
424	3x48	5x53	ox2_on	0	33.3333	No	No	No	No	6	7
425	I2x50	I2x51	ox2_on	0	66.6667	No	No	No	No	9	7
426	3x22	3x26	ox2_on	0	66.6667	No	No	No	No	4	6
427	2x41	4x42	ox2_on	0	33.3333	No	No	No	No	4	7
428	2x37	2x39	ox2_on	0	33.3333	No	No	No	No	7	8
429	1x60	8x57	ox2_on	0	33.3333	No	Yes	No	No	6	6
430	E2.F207	E2.T208	ox2_on	0	33.3333	Yes	No	No	No	3	3
431	4x63	4x64	ox2_on	0	0	No	No	No	No	5	6
432	2x42	3x49	ox2_on	0	33.3333	Yes	Yes	No	No	8	9
433	1x36	2x61	ox2_on	0	33.3333	No	No	No	No	5	6
434	6x49	6x53	ox2_on	0	0	No	No	No	No	6	5
435	6x38	6x41	ox2_on	0	0	No	Yes	No	Yes	6	8
436	3x51	5x61	ox2_on	0	0	Yes	Yes	No	No	8	9
437	1x56	8x54	ox2_on	0	0	No	No	Yes	Yes	8	7
438	1x54	2x47	ox2_on	0	33.3333	No	No	No	No	6	9
439	E3.T336	Lig	ox2_on	0	33.3333	No	No	Yes	Yes	4	0
440	1x33	1x35	ox2_on	0	33.3333	No	No	No	No	4	5
441	2x38	4x39	ox2_on	0	33.3333	No	No	No	No	6	3
442	E2.E217	E2.G216	ox2_on	0	33.3333	No	No	No	No	3	5
443	E2.V209	Lig	ox2_on	0	33.3333	No	No	Yes	Yes	5	0
444	2x59	3x32	ox2_on	0	0	No	No	Yes	Yes	4	7
445	E2.F197	E2.G199	ox2_on	0	33.3333	Yes	No	No	No	2	0
446	2x50	3x39	ox2_on	0	33.3333	No	Yes	No	No	9	9
447	6x32	6x36	ox2_on	0	33.3333	No	No	No	No	8	8
448	5x37	5x38	ox2_on	0	33.3333	No	No	No	No	4	4
449	E2.K203	E2.L200	ox2_on	0	33.3333	No	No	No	No	3	0
450	5x67	5x68	ox2_on	0	33.3333	No	No	No	No	5	7
451	1x33	NT.E52	ox2_on	0	33.3333	No	No	No	No	4	3
452	1x46	7x47	ox2_on	0	0	No	No	No	No	8	5
453	8x54	8x58	ox2_on	0	33.3333	Yes	Yes	No	No	7	5
454	1x38	1x41	ox2_on	0	33.3333	No	No	No	No	4	3
455	1x48	1x49	ox2_on	0	0	No	No	No	No	4	8
456	5x68	5x70	ox2_on	0	33.3333	No	No	No	No	7	0
457	3x55	5x64	ox2_on	0	0	No	No	No	No	7	5
458	1x59	8x57	ox2_on	0	33.3333	No	No	No	No	6	6
459	1x31	1x32	ox2_on	0	33.3333	Yes	No	No	No	4	7
460	3x24	3x27	ox2_on	0	0	No	Yes	No	No	5	4
461	E2.L206	E2.T195	ox2_on	0	33.3333	No	No	No	No	4	2
462	7x26	E3.T336	ox2_on	0	33.3333	No	No	No	No	3	4
463	E2.F197	E2.P198	ox2_on	0	33.3333	Yes	No	No	No	2	2
464	7x51	7x56	ox2_on	0	0	No	No	No	No	6	7
465	1x32	1x35	ox2_on	0	33.3333	No	No	No	No	7	5
466	3x30	3x31	ox2_on	0	0	No	Yes	No	No	6	5
467	7x48	7x51	ox2_on	0	33.3333	No	No	No	No	6	6
468	E2.S194	E2.V209	ox2_on	0	0	No	No	No	No	3	5
469	6x25	6x29	ox2_on	0	0	No	No	No	No	3	6
470	1x44	1x45	ox2_on	0	0	No	No	No	No	4	5
471	6x39	6x43	ox2_on	0	0	No	No	No	No	6	6
472	5x52	5x56	ox2_on	0	0	No	No	No	No	4	4
473	1x60	8x56	ox2_on	0	0	No	Yes	No	No	6	4
474	E2.K203	E2.T205	ox2_on	0	0	No	No	No	No	3	3
475	3x23	3x24	ox2_on	0	0	No	No	No	Yes	3	5
476	6x38	6x42	ox2_on	0	0	No	Yes	No	No	6	4
477	5x59	6x38	ox2_on	0	0	No	No	No	Yes	2	6
478	1x43	1x44	ox2_on	0	0	No	No	No	No	6	4
479	1x55	8x58	ox2_on	0	0	No	No	No	No	5	5
480	6x28	6x31	ox2_on	0	0	No	No	No	No	5	5
481	E3.A334	Lig	ox2_on	0	0	No	No	Yes	Yes	2	0
482	6x23	6x27	ox2_on	0	0	No	No	No	No	0	4
483	6x23	6x24	ox2_on	0	0	No	No	No	No	0	0
484	5x39	5x42	ox2_on	0	0	Yes	Yes	No	No	8	4
485	4x43	4x47	ox2_on	0	0	No	No	No	No	4	3
486	8x54	8x55	ox2_on	0	0	Yes	Yes	No	No	7	5

Orange: nodes, hubs and links specific of ox2_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of ox2_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	ox2_off Avg Int. Strength	ox2_on Avg Int. Strength	ox2_off Num Of Links	ox2_on Num Of Links	ConSurf
1	NT.K51	ox2_off	0	0	4	1	4
2	1x31	ox2_off	0	0	4	1	4
3	1x52	ox2_off	0	0	4	2	6
4	2x53	ox2_off	0	0	4	3	7
5	2x551	ox2_off	0	0	4	1	5
6	2x60	ox2_off	100	0	5	3	7
7	2x66	ox2_off	50	0	4	3	5
8	3x50	ox2_off	50	0	4	3	9
9	3x52	ox2_off	25	0	4	3	4
10	3x56	ox2_off	100	0	5	3	6
11	I2x53	ox2_off	0	0	4	0	7
12	4x56	ox2_off	0	0	4	3	5
13	4x57	ox2_off	25	33.3333	4	3	7
14	E2.F197	ox2_off	0	0	4	3	2
15	E2.F207	ox2_off	0	0	5	3	3
16	5x40	ox2_off	50	0	4	3	6
17	5x43	ox2_off	100	0	5	3	5
18	5x66	ox2_off	25	0	5	2	5
19	6x37	ox2_off	0	0	4	2	8
20	7x27	ox2_off	25	0	4	2	1
21	7x40	ox2_off	50	0	4	2	8
22	7x45	ox2_off	25	0	4	3	9
23	5x71	ox2_off	25	0	5	0	0
24	1x39	Shared	100	66.6667	6	5	7
25	I1x50	Shared	75	33.3333	4	4	8
26	2x42	Shared	100	66.6667	5	5	8
27	2x56	Shared	75	0	4	4	7
28	2x57	Shared	100	66.6667	4	4	7
29	E1x50	Shared	100	66.6667	6	4	7
30	3x32	Shared	50	0	4	4	7
31	3x51	Shared	100	100	5	6	8
32	4x61	Shared	100	33.3333	4	4	6
33	E2x52	Shared	100	100	5	6	4
34	E2.W214	Shared	100	66.6667	6	6	4
35	5x39	Shared	75	33.3333	5	5	8
36	5x44	Shared	25	33.3333	4	4	6
37	5x47	Shared	50	66.6667	4	4	8
38	5x58	Shared	75	100	4	6	9
39	6x44	Shared	25	100	4	5	9
40	6x48	Shared	100	66.6667	4	4	7
41	6x59	Shared	100	33.3333	4	4	4
42	7x34	Shared	50	33.3333	4	4	4
43	7x38	Shared	75	66.6667	4	4	5
44	7x39	Shared	50	0	5	5	5
45	7x42	Shared	100	100	6	6	7
46	7x53	Shared	75	100	4	5	9
47	8x50	Shared	100	33.3333	5	4	8
48	8x54	Shared	25	0	4	5	7
49	Lig	Shared	100	100	9	17	0
50	1x50	ox2_on	0	33.3333	3	4	9
51	1x60	ox2_on	0	0	3	5	6
52	2x46	ox2_on	0	33.3333	2	4	9
53	2x50	ox2_on	0	66.6667	2	5	9
54	3x24	ox2_on	0	0	1	4	5
55	3x30	ox2_on	25	0	3	5	6
56	3x43	ox2_on	0	33.3333	2	4	9
57	6x38	ox2_on	0	0	1	4	6
58	6x41	ox2_on	0	0	1	4	8
59	6x51	ox2_on	0	33.3333	3	4	7
60	6x60	ox2_on	0	0	3	4	5
61	E3.F333	ox2_on	75	33.3333	3	4	4
62	7x49	ox2_on	0	33.3333	3	4	9

Orange: nodes, hubs and links specific of ox2_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of ox2_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	ox2_off Recurrence	ox2_on Recurrence	ox2_off Hub1?	ox2_on Hub1?	ox2_off Hub2?	ox2_on Hub2?	ConSurf1	ConSurf2
1	NT.F39	NT.Y42	ox2_off	11.421	0	No	No	No	No	5	4
2	NT.E46	NT.Y42	ox2_off	22.8742	0	No	No	No	No	7	4
3	NT.E46	NT.K51	ox2_off	20.359	0	No	No	Yes	No	7	4
4	2x67	NT.K51	ox2_off	12.4029	0	No	No	Yes	No	4	4
5	1x39	2x60	ox2_off	28.2506	0	Yes	Yes	Yes	No	7	7
6	3x28	E1x50	ox2_off	69.371	0	No	No	Yes	Yes	5	7
7	2x62	E1x52	ox2_off	55.9781	0	No	No	No	No	4	6
8	2x62	2x66	ox2_off	55.0243	2.7137	No	No	Yes	No	4	5
9	2x66	NT.Y42	ox2_off	34.5688	0	Yes	No	No	No	5	4
10	1x53	8x54	ox2_off	13.8476	0	No	No	Yes	Yes	9	7
11	8x50	8x54	ox2_off	40.5811	0	Yes	Yes	Yes	Yes	8	7
12	7x53	8x50	ox2_off	65.3185	0	Yes	Yes	Yes	Yes	9	8
13	7x49	7x53	ox2_off	95.1185	0	No	Yes	Yes	Yes	9	9
14	7x45	7x49	ox2_off	100	8.08845	Yes	No	No	Yes	9	9
15	3x36	6x48	ox2_off	88.8366	0	No	No	Yes	Yes	6	7
16	3x36	Lig	ox2_off	89.2712	1.79956	No	No	Yes	Yes	6	0
17	1x58	2x44	ox2_off	13.9201	0	No	No	No	No	3	6
18	1x57	2x44	ox2_off	15.2682	2.17766	No	No	No	No	7	6
19	1x57	I1x50	ox2_off	16.6083	4.37446	No	No	Yes	Yes	7	8
20	2x551	2x56	ox2_off	14.403	1.63205	Yes	No	Yes	Yes	5	7
21	2x39	6x37	ox2_off	10.7449	0	No	No	Yes	No	8	8
22	3x46	6x37	ox2_off	40.8548	0	No	No	Yes	No	8	8
23	2x42	3x42	ox2_off	44.6014	0	Yes	Yes	No	No	8	7
24	3x42	4x49	ox2_off	45.2413	0	No	No	No	No	7	6
25	3x38	4x49	ox2_off	47.358	0	No	No	No	No	7	6
26	3x38	4x53	ox2_off	53.2376	5.12587	No	No	No	No	7	8
27	3x37	4x53	ox2_off	54.2638	2.56533	No	No	No	No	7	8
28	3x37	4x56	ox2_off	55.2819	0	No	No	Yes	No	7	5
29	4x57	5x43	ox2_off	62.5337	7.58591	Yes	No	Yes	No	7	5
30	5x43	Lig	ox2_off	75.2586	8.95472	Yes	No	Yes	Yes	5	0
31	2x66	E1x49	ox2_off	10.6322	8.12195	Yes	No	No	No	5	5
32	3x55	5x61	ox2_off	21.0029	0	No	No	No	No	7	9
33	5x66	6x35	ox2_off	36.7741	0	Yes	No	No	No	5	8
34	6x35	7x56	ox2_off	42.5168	0	No	No	No	No	8	7
35	6x36	7x56	ox2_off	43.1848	6.25538	No	No	No	No	8	7
36	6x36	7x53	ox2_off	44.2915	0	No	No	Yes	Yes	8	9
37	5x39	5x43	ox2_off	18.7492	0	Yes	Yes	Yes	No	8	5
38	5x39	E2.W214	ox2_off	16.1254	8.13152	Yes	Yes	Yes	Yes	8	4
39	E1x51	NT.E38	ox2_off	10.3344	0	No	No	No	No	4	0
40	2x66	E1x51	ox2_off	11.4572	0	Yes	No	No	No	5	4
41	5x35	E2.W214	ox2_off	10.0769	2.9195	No	No	Yes	Yes	3	4
42	5x47	6x49	ox2_off	17.9404	7.31789	Yes	Yes	No	No	8	6
43	6x49	6x50	ox2_off	19.2644	4.37925	No	No	No	No	6	9
44	6x50	7x40	ox2_off	20.5803	4.42232	No	No	Yes	No	9	8
45	7x39	7x40	ox2_off	24.331	0	Yes	Yes	Yes	No	5	8
46	6x27	6x31	ox2_off	17.8398	5.52312	No	No	No	No	4	5
47	6x47	7x45	ox2_off	17.6546	1.71341	No	No	Yes	No	8	9
48	6x54	7x34	ox2_off	11.3928	1.58419	No	No	Yes	Yes	5	4
49	7x34	7x38	ox2_off	19.6708	0	Yes	Yes	Yes	Yes	4	5
50	8x61	8x62	ox2_off	10.3304	0	No	No	No	No	3	1
51	8x58	8x62	ox2_off	11.6946	0	No	No	No	No	5	1
52	1x52	8x58	ox2_off	13.0468	0	Yes	No	No	No	6	5
53	1x52	8x54	ox2_off	18.1979	6.55691	Yes	No	Yes	Yes	6	7
54	NT.F39	NT.L43	ox2_off	10.2258	0	No	No	No	No	5	8
55	6x47	7x40	ox2_off	16.7371	0	No	No	Yes	No	8	8
56	2x60	Lig	Shared	33.2569	10.6251	Yes	No	Yes	Yes	7	0
57	3x29	Lig	Shared	73.3792	21.1448	No	No	Yes	Yes	5	0
58	3x28	3x29	Shared	71.4395	22.3461	No	No	No	No	5	5
59	E1x50	E1x52	Shared	58.2196	24.117	Yes	Yes	No	No	7	6
60	3x32	Lig	Shared	21.5059	39.7722	Yes	Yes	Yes	Yes	7	0
61	1x39	7x39	Shared	27.2607	15.7174	Yes	Yes	Yes	Yes	7	5
62	6x48	7x45	Shared	83.5044	10.0029	Yes	Yes	Yes	No	7	9
63	8x50	I1x50	Shared	25.7636	27.9123	Yes	Yes	Yes	Yes	8	8
64	2x56	3x32	Shared	13.1877	54.5276	Yes	Yes	Yes	Yes	7	7
65	2x42	3x46	Shared	41.8045	24.5812	Yes	Yes	No	No	8	8
66	4x56	4x57	Shared	59.274	13.0947	Yes	No	Yes	No	5	7
67	7x38	Lig	Shared	18.9746	10.8309	Yes	Yes	Yes	Yes	5	0
68	3x25	E1x50	Shared	10.0527	16.1338	No	No	Yes	Yes	9	7
69	4x61	Lig	Shared	27.0313	48.5881	Yes	Yes	Yes	Yes	6	0
70	5x58	6x37	Shared	29.5143	11.6876	Yes	Yes	Yes	No	9	8
71	3x51	3x55	Shared	19.7231	11.2329	Yes	Yes	No	No	8	7
72	5x58	5x61	Shared	22.2745	55.5327	Yes	Yes	No	No	9	9
73	4x60	5x39	Shared	14.7732	12.1279	No	No	Yes	Yes	6	8
74	4x61	5x39	Shared	14.4151	23.222	Yes	Yes	Yes	Yes	6	8
75	4x61	E2x52	Shared	11.916	25.3996	Yes	Yes	Yes	Yes	6	4
76	5x44	5x47	Shared	11.1675	23.7149	Yes	Yes	Yes	Yes	6	8
77	5x66	6x31	Shared	27.2647	12.8793	Yes	No	No	No	5	5
78	4x59	4x60	Shared	12.3305	10.448	No	No	No	No	5	6
79	1x35	7x35	ox2_on	0	11.7211	No	No	No	No	5	4
80	1x39	7x35	ox2_on	0	14.9469	Yes	Yes	No	No	7	4
81	1x39	7x42	ox2_on	2.3341	33.6365	Yes	Yes	Yes	Yes	7	7
82	1x43	2x57	ox2_on	8.91786	14.43	No	No	Yes	Yes	6	7
83	2x56	7x42	ox2_on	2.51922	31.387	Yes	Yes	Yes	Yes	7	7
84	2x53	2x56	ox2_on	0.0845104	45.793	Yes	No	Yes	Yes	7	7
85	2x53	7x46	ox2_on	0	46.8268	Yes	No	No	No	7	9
86	2x50	7x46	ox2_on	2.80897	47.6213	No	Yes	No	No	9	9
87	1x50	2x50	ox2_on	5.61391	87.0681	No	Yes	No	Yes	9	9
88	1x50	2x47	ox2_on	4.2054	79.8315	No	Yes	No	No	9	9
89	1x53	2x47	ox2_on	5.58976	74.2797	No	No	No	No	9	9
90	1x53	7x54	ox2_on	0	72.3988	No	No	No	No	9	7
91	7x54	8x50	ox2_on	0	63.2287	No	No	Yes	Yes	7	8
92	1x60	I1x50	ox2_on	7.05863	17.2968	No	Yes	Yes	Yes	6	8
93	1x60	8x57	ox2_on	0	10.9314	No	Yes	No	No	6	6
94	7x41	7x42	ox2_on	0	34.0289	No	No	Yes	Yes	7	7
95	6x48	7x41	ox2_on	1.56546	100	Yes	Yes	No	No	7	7
96	6x44	6x48	ox2_on	6.50328	86.6852	Yes	Yes	Yes	Yes	9	7
97	3x43	6x44	ox2_on	4.49918	64.7171	No	Yes	Yes	Yes	9	9
98	3x43	7x53	ox2_on	0	50.9524	No	Yes	Yes	Yes	9	9
99	3x46	7x53	ox2_on	0	23.8729	No	No	Yes	Yes	8	9
100	2x46	2x50	ox2_on	0	40.8778	No	Yes	No	Yes	9	9
101	2x46	3x42	ox2_on	0	20.2881	No	Yes	No	No	9	7
102	2x45	3x42	ox2_on	0.474868	17.785	No	No	No	No	9	7
103	2x46	3x43	ox2_on	3.00616	42.8592	No	Yes	No	Yes	9	9
104	2x45	4x50	ox2_on	3.0464	12.7501	No	No	No	No	9	9
105	2x60	7x42	ox2_on	6.26182	11.1515	Yes	No	Yes	Yes	7	7
106	7x38	7x42	ox2_on	0	11.6014	Yes	Yes	Yes	Yes	5	7
107	3x28	3x32	ox2_on	0	51.6464	No	No	Yes	Yes	5	7
108	3x24	3x28	ox2_on	1.46082	70.6662	No	Yes	No	No	5	5
109	3x24	E1x52	ox2_on	0	63.2861	No	Yes	No	No	5	6
110	E1x51	E1x52	ox2_on	0	38.0636	No	No	No	No	4	6
111	E1x49	E1x51	ox2_on	0.229385	35.4887	No	No	No	No	5	4
112	E1x49	E2.F207	ox2_on	9.44907	25.0838	No	No	Yes	No	5	3
113	3x38	4x50	ox2_on	4.87344	10.2182	No	No	No	No	7	9
114	3x40	5x50	ox2_on	3.00616	10.7639	No	No	No	No	8	9
115	3x50	7x53	ox2_on	0	18.9289	Yes	No	Yes	Yes	9	9
116	5x54	6x44	ox2_on	0	78.7595	No	No	Yes	Yes	8	9
117	5x54	5x58	ox2_on	0	50.1101	No	No	Yes	Yes	8	9
118	3x50	5x58	ox2_on	0	21.164	Yes	No	Yes	Yes	9	9
119	3x51	5x61	ox2_on	0	51.3018	Yes	Yes	No	No	8	9
120	3x51	3x52	ox2_on	6.57974	24.1265	Yes	Yes	Yes	No	8	4
121	3x52	4x41	ox2_on	0	19.2687	Yes	No	No	No	4	7
122	4x38	4x41	ox2_on	2.74458	17.4165	No	No	No	No	5	7
123	4x38	4x40	ox2_on	0	14.9564	No	No	No	No	5	5
124	4x40	4x44	ox2_on	0	12.4868	No	No	No	No	5	3
125	4x43	4x44	ox2_on	1.4246	10.0077	No	No	No	No	4	3
126	3x25	E2.C193	ox2_on	8.66433	13.4919	No	No	No	No	9	4
127	3x22	E2.C193	ox2_on	7.23973	10.8117	No	No	No	No	4	4
128	E2.F207	E2.T208	ox2_on	0	20.6231	Yes	No	No	No	3	3
129	E2.T195	E2.T208	ox2_on	6.41877	17.9573	No	No	No	No	2	3
130	E2.L206	E2.T195	ox2_on	0	15.7126	No	No	No	No	4	2
131	E2.F197	E2.L206	ox2_on	1.24351	13.468	Yes	No	No	No	2	4
132	6x59	E2x52	ox2_on	3.0303	14.3486	Yes	Yes	Yes	Yes	4	4
133	5x44	6x56	ox2_on	5.6622	14.0327	Yes	Yes	No	No	6	6
134	6x56	6x60	ox2_on	4.25772	12.0561	No	No	No	Yes	6	5
135	5x51	6x44	ox2_on	0	35.2206	No	No	Yes	Yes	6	9
136	5x47	5x51	ox2_on	4.25772	31.7077	Yes	Yes	No	No	8	6
137	5x54	6x41	ox2_on	1.39643	27.2806	No	No	No	Yes	8	8
138	6x38	6x41	ox2_on	0	27.5486	No	Yes	No	Yes	6	8
139	5x62	6x38	ox2_on	0	18.2493	No	No	No	Yes	6	6
140	5x62	5x66	ox2_on	1.4246	14.7889	No	No	Yes	No	6	5
141	7x55	8x50	ox2_on	0	33.4259	No	No	Yes	Yes	5	8
142	7x51	7x55	ox2_on	1.4246	12.7596	No	No	No	No	6	5
143	6x51	7x41	ox2_on	1.96789	66.9187	No	Yes	No	No	7	7
144	6x58	6x59	ox2_on	1.97191	12.0417	No	No	Yes	Yes	3	4
145	7x55	8x54	ox2_on	0	19.0868	No	No	Yes	Yes	5	7
146	2x57	7x42	ox2_on	7.9641	16.7943	Yes	Yes	Yes	Yes	7	7
147	2x50	7x49	ox2_on	0	35.996	No	Yes	No	Yes	9	9
148	3x43	7x49	ox2_on	0	33.6652	No	Yes	No	Yes	9	9
149	6x51	Lig	ox2_on	2.96591	65.5738	No	Yes	Yes	Yes	7	0

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
1x39	2x60	ox2_off	4.6825	0	1	1	2	1
1x39	7x42	Shared	5.4625	4.3	1	1	2	2
2x53	2x56	Shared	5.9775	3.41333	1	0	2	2
2x53	3x32	ox2_off	3.94	0	1	0	2	1
2x53	7x42	ox2_off	3.47	0	1	0	2	2
2x56	3x32	Shared	6.1	7.12	1	0	2	1
2x56	7x42	Shared	3.695	6.27	1	0	2	2
2x60	2x64	ox2_off	3.9775	0	1	1	1	2
2x60	7x38	Shared	4.11	8.21667	1	1	1	1
2x60	7x42	Shared	10.3025	7.07333	1	1	1	2
2x60	Lig	Shared	8.11	4.27667	1	1	1	0
2x64	7x38	ox2_off	8.505	0	1	0	2	1
2x67	7x27	ox2_off	4.6525	0	2	0	2	1
2x67	7x31	Shared	10.1025	11.2233	2	0	2	1
3x28	E1x50	ox2_off	4.405	0	0	0	2	2
3x29	4x65	Shared	8.3875	3.91333	0	0	1	2
3x29	Lig	Shared	14.05	3.86333	0	0	1	0
3x32	7x42	ox2_off	7.0475	0	1	0	1	2
3x32	Lig	Shared	16.08	15.2967	1	0	1	0
3x33	4x57	Shared	9.785	8.02667	1	1	1	2
3x33	4x61	Shared	6.7325	6.14	1	1	1	1
3x33	5x43	ox2_off	5.515	0	1	1	1	1
3x36	6x48	ox2_off	5.995	0	0	0	1	2
3x36	Lig	Shared	4.84	10.5733	0	0	1	0
4x57	5x43	Shared	5.29	4.98	1	0	2	1
4x61	E2x52	Shared	7.965	4.24667	0	1	1	2
4x61	5x39	Shared	9.585	3.75667	0	1	1	2
4x61	Lig	Shared	5.36	3.37	0	1	1	0
5x40	E2x52	Shared	9.5425	9.03	4	1	2	2
5x39	5x40	Shared	6.535	4.71667	0	0	2	2
5x39	5x43	ox2_off	4.125	0	0	0	2	1
5x40	6x55	ox2_off	6.0575	0	4	1	2	1
5x43	5x461	Shared	14.915	3.89	1	1	1	1
5x43	Lig	Shared	11.6025	6.40667	1	1	1	0
6x48	7x41	Shared	8.83	4.20333	7	2	2	2
6x51	7x37	Shared	5.805	4.13	0	1	1	2
6x51	7x41	Shared	3.455	3.58667	0	1	1	2
6x51	Lig	Shared	13.54	5.70667	0	1	1	0
6x55	Lig	Shared	11.26	9.91333	0	0	1	0
7x27	7x31	Shared	8.745	6.86	2	1	1	1
7x34	7x38	ox2_off	3.9575	0	0	1	2	1
7x38	Lig	Shared	14.9075	7.78667	1	1	1	0
3x28	3x29	Shared	3.39	3.95333	0	0	2	1
E2.F207	E2.V209	ox2_off	2.9475	0	0	0	2	1
7x27	NT.H49	ox2_off	2.54	0	2	1	1	2
2x63	E1x50	ox2_off	2.45	0	0	0	1	2
7x27	E3.T336	ox2_off	2.2625	0	2	1	1	1
E3.A334	E3.H335	Shared	0.365	1.46333	0	0	1	2
2x63	Lig	ox2_on	0	5.05667	0	0	1	0
3x28	3x32	ox2_on	0	3.20333	0	0	2	1
3x33	Lig	ox2_on	0	5.16667	1	1	1	0
4x65	E2x52	ox2_on	0	3.61	0	0	2	2
6x51	7x38	ox2_on	0	5.30333	0	1	1	1
7x31	Lig	ox2_on	0	7.89	2	1	1	0
7x38	7x42	ox2_on	0	5.44333	1	1	1	2
7x41	7x42	ox2_on	0	4.21	0	0	2	2
5x461	Lig	ox2_on	0	3.18333	0	1	1	0
7x27	Lig	ox2_on	0	6.01667	2	1	1	0
E3.T336	Lig	ox2_on	0	2.28333	0	0	1	0
E2.V209	Lig	ox2_on	0	2.11333	0	0	1	0
2x59	3x32	ox2_on	0	2.02333	0	0	2	1
7x26	E3.T336	ox2_on	0	1.44667	0	0	2	1
E2.S194	E2.V209	ox2_on	0	1.08	0	0	2	1
E3.A334	Lig	ox2_on	0	0.52	0	0	1	0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	ox2_off	5WQC-OX₂-EMPA 6TPN-OX₂-HTL6641 7XRR-OX₂-Lemborexant 6TPJ-OX₂-Suvorexant
	ox2_on	7L1V-OX₂-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX₂-TAK-925-Gi1/β1/γ2 7L1U-OX₂-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2

Network Difference
Value	ox2_off	ox2_on
I_min	3.4025	3.18
Number of Linked Nodes	322	287
Number of Specific Nodes	40 (12.42%)	5 (1.74%)
Number of Shared Nodes	282 (87.58%)	282 (98.26%)
Number of Links	351	317
Number of Specific Links	169 (48.15%)	135 (42.59%)
Number of Shared Links	182 (51.85%)	182 (57.41%)
Number of Hubs	49	39
Number of Specific Hubs	23 (46.94%)	13 (33.33%)
Number of Shared Hubs	26 (53.06%)	26 (66.67%)
Average % Shared Neighbours (Jaccard)	39.07
Average % Shared Neighbours (Otsuka)	48.02
Average % Shared Neighbours (Overlap Coefficient)	56.98
Average % Shared Cliques (k3-6)	54.29
Graphlets Similarity	0.623329

Paths Difference
Value	ox2_off	ox2_on
Number Of Nodes in MetaPath	77	90
Specific Nodes in MetaPath	35 (45.45%)	48 (53.33%)
Shared Nodes in MetaPath	282 (87.58%)	282 (87.58%)
Number Of Links MetaPath	78	94
Specific Links in MetaPath	55 (70.51%)	71 (75.53%)
Shared Links in MetaPath	182 (51.85%)	182 (51.85%)
Number of Shortest Paths	61089	62790
Length Of Smallest Path	3	3
Average Path Length	15.0486	13.2706
Length of Longest Path	37	32
Minimum Path Strength	0.49	0.731667
Average Path Strength	5.97843	5.306
Maximum Path Strength	19.79	20.9667
Minimum Path Correlation	0.7025	0.7
Average Path Correlation	0.924255	0.923274
Maximum Path Correlation	0.99	0.99
Minimum % Of Corr. Nodes	2.85714	3.33333
Average % Of Corr. Nodes	46.2346	46.1061
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	45.7495	46.7899
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

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