psnGPCR

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Orange: nodes, hubs and links specific of p2y1_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of p2y1_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	p2y1_off Int. Strength	p2y1_on Int. Strength	p2y1_off Hub1?	p2y1_on Hub1?	p2y1_off Hub2?	p2y1_on Hub2?	ConSurf1	ConSurf2
1	7x31	NT.L44	p2y1_off	18.76	0	Yes	No	No	No	4	2
2	Lig	NT.L44	p2y1_off	19.89	0	Yes	Yes	No	No	0	2
3	7x28	NT.T45	p2y1_off	8.67	0	No	No	No	No	2	3
4	1x32	NT.K46	p2y1_off	7.44	0	No	No	No	No	3	4
5	E1.T115	NT.K46	p2y1_off	9.01	0	Yes	No	No	No	4	4
6	Lig	NT.K46	p2y1_off	5.29	0	Yes	Yes	No	No	0	4
7	1x30	1x35	p2y1_off	9.74	0	No	No	No	Yes	4	6
8	1x30	7x36	p2y1_off	9.18	0	No	No	No	No	4	5
9	1x31	7x31	p2y1_off	10.15	0	No	No	Yes	No	4	4
10	1x32	E1.K114	p2y1_off	12.41	0	No	No	No	No	3	3
11	1x33	E1.K114	p2y1_off	5.97	0	No	No	No	No	3	3
12	1x36	2x64	p2y1_off	5.56	0	No	No	No	Yes	6	5
13	1x36	2x65	p2y1_off	15.89	0	No	No	No	No	6	4
14	1x39	2x60	p2y1_off	9.38	0	Yes	Yes	No	No	7	7
15	1x47	1x51	p2y1_off	7.93	0	No	No	No	No	5	3
16	1x50	7x50	p2y1_off	9.77	0	No	No	No	No	9	9
17	1x51	2x51	p2y1_off	5.28	0	No	No	Yes	No	3	7
18	1x57	2x40	p2y1_off	5.28	0	Yes	Yes	No	No	6	7
19	1x57	7x53	p2y1_off	5.16	0	Yes	Yes	Yes	Yes	6	9
20	I1.K81	I1.W83	p2y1_off	12.76	0	No	No	Yes	Yes	6	6
21	4x39	I1.W83	p2y1_off	6.96	0	No	No	Yes	Yes	3	6
22	2x37	8x48	p2y1_off	8.83	0	No	No	No	No	7	5
23	2x38	3x49	p2y1_off	4.77	0	No	No	No	No	6	8
24	2x39	2x43	p2y1_off	4.37	0	Yes	No	Yes	No	7	8
25	2x39	3x50	p2y1_off	11.27	0	Yes	No	Yes	No	7	9
26	2x39	8x48	p2y1_off	5.6	0	Yes	No	No	No	7	5
27	2x40	8x48	p2y1_off	5.89	0	No	No	No	No	7	5
28	2x41	4x42	p2y1_off	5.09	0	No	No	No	No	6	8
29	2x43	3x46	p2y1_off	4.37	0	Yes	No	No	Yes	8	8
30	2x43	7x53	p2y1_off	5.99	0	Yes	No	Yes	Yes	8	9
31	2x44	2x48	p2y1_off	6.09	0	Yes	No	No	No	5	5
32	2x46	7x53	p2y1_off	5.86	0	No	No	Yes	Yes	9	9
33	2x47	7x53	p2y1_off	5.34	0	No	No	Yes	Yes	9	9
34	2x50	3x35	p2y1_off	6.73	0	Yes	No	No	No	9	8
35	2x50	7x46	p2y1_off	10.31	0	Yes	No	No	No	9	9
36	2x50	7x49	p2y1_off	6.73	0	Yes	No	No	No	9	9
37	2x53	7x42	p2y1_off	6.36	0	Yes	Yes	No	No	7	7
38	2x53	7x46	p2y1_off	5.09	0	Yes	Yes	No	No	7	9
39	2x54	2x57	p2y1_off	4.47	0	No	No	Yes	Yes	5	7
40	2x60	3x28	p2y1_off	5.32	0	No	No	No	Yes	7	4
41	2x62	2x66	p2y1_off	8.46	0	No	No	No	No	3	4
42	2x62	E1x52	p2y1_off	5.36	0	No	No	Yes	Yes	3	7
43	2x66	E1x49	p2y1_off	5.39	0	No	No	No	No	4	5
44	E1.T115	E2.R195	p2y1_off	5.17	0	Yes	No	Yes	Yes	4	1
45	3x26	E2.G191	p2y1_off	5.23	0	No	No	No	No	7	4
46	3x29	4x64	p2y1_off	5.27	0	No	Yes	No	No	5	5
47	3x30	3x34	p2y1_off	7.87	0	Yes	No	No	No	6	5
48	3x34	4x53	p2y1_off	4.81	0	No	No	No	No	5	7
49	3x35	3x39	p2y1_off	4.47	0	No	No	No	No	8	9
50	3x36	3x37	p2y1_off	14.07	0	No	No	Yes	No	7	7
51	3x37	5x43	p2y1_off	4.99	0	Yes	No	No	No	7	5
52	3x37	6x52	p2y1_off	7.62	0	Yes	No	No	Yes	7	8
53	3x42	4x46	p2y1_off	5.28	0	Yes	Yes	No	No	7	7
54	3x44	5x54	p2y1_off	6.08	0	No	No	No	No	8	8
55	3x47	5x54	p2y1_off	6.19	0	No	No	No	No	9	8
56	3x50	6x30	p2y1_off	4.86	0	Yes	No	No	No	9	4
57	3x50	6x33	p2y1_off	6.19	0	Yes	No	No	No	9	8
58	3x52	I2x56	p2y1_off	6.59	0	Yes	No	No	No	5	4
59	I2x51	I2x52	p2y1_off	5.64	0	No	No	No	No	5	5
60	4x39	4x43	p2y1_off	4.36	0	No	No	No	No	3	4
61	4x47	4x51	p2y1_off	4.47	0	No	No	No	No	4	4
62	4x60	4x64	p2y1_off	4.64	0	No	No	No	No	4	5
63	4x62	4x63	p2y1_off	7.22	0	No	No	Yes	No	4	4
64	4x63	E2.T206	p2y1_off	8.74	0	Yes	No	No	No	4	5
65	E2.R195	E2.T199	p2y1_off	9.06	0	Yes	Yes	No	No	1	4
66	6x62	E2.T205	p2y1_off	6.47	0	No	Yes	No	Yes	5	5
67	E2.T206	E2.Y210	p2y1_off	4.99	0	No	No	No	No	5	4
68	5x36	6x55	p2y1_off	4.78	0	Yes	Yes	No	Yes	4	6
69	5x36	6x59	p2y1_off	4.69	0	Yes	Yes	No	No	4	4
70	5x37	5x41	p2y1_off	7.46	0	No	No	No	No	4	4
71	5x51	6x45	p2y1_off	8.53	0	No	No	No	No	6	9
72	5x58	6x37	p2y1_off	8.21	0	Yes	Yes	No	No	9	7
73	6x29	8x52	p2y1_off	7.21	0	No	No	No	No	4	5
74	6x33	8x49	p2y1_off	9.01	0	No	No	No	No	8	6
75	6x36	7x55	p2y1_off	9.38	0	No	No	No	No	6	6
76	6x44	6x48	p2y1_off	5.05	0	No	No	Yes	Yes	6	8
77	6x48	7x45	p2y1_off	11.63	0	Yes	Yes	No	No	8	9
78	6x58	Lig	p2y1_off	13.73	0	No	No	Yes	Yes	4	0
79	6x60	E3.F290	p2y1_off	5.34	0	No	No	No	No	4	3
80	6x61	7x27	p2y1_off	4.69	0	No	No	No	No	1	2
81	7x23	E3.F290	p2y1_off	8.71	0	No	No	No	No	4	3
82	7x23	7x27	p2y1_off	5.61	0	No	No	No	No	4	2
83	7x26	7x27	p2y1_off	4.83	0	No	No	No	No	1	2
84	7x34	Lig	p2y1_off	4.4	0	No	Yes	Yes	Yes	4	0
85	7x49	7x53	p2y1_off	4.65	0	No	No	Yes	Yes	9	9
86	8x49	8x52	p2y1_off	11.64	0	No	No	No	No	6	5
87	8x50	8x51	p2y1_off	31	0	No	No	No	No	8	8
88	1x39	7x39	p2y1_off	4.35	0	Yes	Yes	No	No	7	4
89	3x32	6x51	p2y1_off	4.29	0	Yes	No	No	No	7	7
90	5x37	6x60	p2y1_off	4.28	0	No	No	No	No	4	4
91	2x59	E1x52	p2y1_off	4.16	0	No	No	Yes	Yes	6	7
92	1x49	7x50	p2y1_off	4.06	0	No	No	No	No	6	9
93	3x50	6x34	p2y1_off	3.95	0	Yes	No	No	No	9	7
94	1x58	2x44	p2y1_off	3.93	0	No	No	Yes	No	3	5
95	3x25	E2.G191	p2y1_off	3.92	0	No	No	No	No	9	4
96	2x49	4x50	p2y1_off	3.89	0	No	No	No	Yes	8	9
97	3x51	3x52	p2y1_off	3.82	0	Yes	Yes	Yes	No	7	5
98	1x54	2x51	p2y1_off	3.77	0	No	No	Yes	No	7	7
99	NT.G48	NT.T47	p2y1_off	3.64	0	No	No	No	No	4	2
100	1x39	2x61	p2y1_off	3.63	0	Yes	Yes	No	No	7	7
101	3x51	5x61	p2y1_off	3.63	0	Yes	Yes	No	No	7	7
102	6x50	7x37	p2y1_off	3.5	0	No	No	No	No	9	7
103	2x43	8x47	p2y1_off	3.49	0	Yes	No	No	No	8	8
104	3x40	5x50	p2y1_off	3.39	0	No	No	No	No	7	9
105	I2x50	I2x52	p2y1_off	3.35	0	No	No	No	No	8	5
106	E3.Q291	Lig	p2y1_off	3.33	0	No	No	Yes	Yes	2	0
107	1x45	7x47	p2y1_off	3.27	0	No	No	No	No	5	7
108	2x41	4x46	p2y1_off	3.23	0	No	No	No	No	6	7
109	6x461	6x47	p2y1_off	3.23	0	No	No	No	No	6	8
110	7x52	7x56	p2y1_off	3.15	0	No	No	No	No	7	6
111	5x62	5x66	p2y1_off	3.07	0	No	No	No	No	5	3
112	6x57	7x30	p2y1_off	3.04	0	No	No	No	No	5	4
113	7x23	E3.T292	p2y1_off	3.01	0	No	No	No	No	4	2
114	6x47	7x43	p2y1_off	3	0	No	No	No	No	8	5
115	1x42	2x57	p2y1_off	2.98	0	No	No	Yes	Yes	6	7
116	3x54	5x65	p2y1_off	2.98	0	No	No	No	No	8	8
117	3x54	6x30	p2y1_off	2.98	0	No	No	No	No	8	4
118	5x49	5x53	p2y1_off	2.98	0	No	No	No	No	6	6
119	6x461	7x40	p2y1_off	2.98	0	No	No	No	No	6	7
120	6x35	6x39	p2y1_off	2.94	0	No	No	No	No	6	4
121	1x33	NT.G48	p2y1_off	2.9	0	No	No	No	No	3	4
122	1x34	NT.G48	p2y1_off	2.9	0	No	No	No	No	5	4
123	7x51	7x55	p2y1_off	2.85	0	No	No	No	No	6	6
124	3x21	E1x50	p2y1_off	2.81	0	No	No	Yes	Yes	6	8
125	5x47	5x48	p2y1_off	2.79	0	No	No	No	No	8	4
126	3x32	7x41	p2y1_off	2.77	0	Yes	No	No	No	7	7
127	1x53	7x53	p2y1_off	2.67	0	No	No	Yes	Yes	8	9
128	5x37	6x56	p2y1_off	2.59	0	No	No	No	No	4	5
129	5x68	6x31	p2y1_off	2.48	0	No	No	No	No	4	6
130	3x53	I2x53	p2y1_off	1.86	0	No	No	No	No	7	5
131	4x38	I2x55	p2y1_off	1.74	0	No	No	No	No	6	4
132	I2x54	I2x55	p2y1_off	1.71	0	No	No	No	No	5	4
133	5x38	5x42	p2y1_off	1.64	0	No	No	No	No	3	3
134	2x43	7x56	p2y1_off	1.61	0	Yes	No	No	No	8	6
135	5x46	5x461	p2y1_off	1.61	0	No	No	No	No	4	5
136	1x38	1x42	p2y1_off	1.6	0	No	No	No	No	4	6
137	NT.K41	NT.S39	p2y1_off	1.53	0	No	No	No	No	1	7
138	1x52	1x56	p2y1_off	1.52	0	No	No	No	Yes	5	7
139	1x40	1x44	p2y1_off	1.47	0	No	No	No	No	5	5
140	1x41	1x45	p2y1_off	1.43	0	No	No	No	No	5	5
141	4x48	4x52	p2y1_off	1.43	0	No	No	No	No	3	5
142	6x40	7x55	p2y1_off	1.43	0	No	No	No	No	4	6
143	7x28	NT.L44	p2y1_off	1.36	0	No	No	No	No	2	2
144	3x30	4x54	p2y1_off	1.31	0	Yes	No	No	No	6	4
145	2x51	2x52	p2y1_off	1.22	0	Yes	No	No	No	7	7
146	1x60	8x50	p2y1_off	1.13	0	No	Yes	No	No	5	8
147	E3.P293	NT.F40	Shared	15.89	4.33	No	No	No	No	1	5
148	E3.Q291	NT.C42	Shared	6.1	3.05	No	No	No	No	2	8
149	7x24	NT.C42	Shared	7.28	5.46	No	No	No	No	4	8
150	1x31	7x35	Shared	17.92	7.68	No	No	No	Yes	4	5
151	1x32	E1.T115	Shared	5.19	3.89	No	No	Yes	No	3	4
152	1x33	1x34	Shared	5.96	8.94	No	No	No	No	3	5
153	1x35	1x39	Shared	14.07	5.86	No	Yes	Yes	Yes	6	7
154	1x35	2x64	Shared	8.21	3.52	No	Yes	No	Yes	6	5
155	1x39	2x57	Shared	4.69	4.69	Yes	Yes	Yes	Yes	7	7
156	1x39	7x42	Shared	7.63	7.63	Yes	Yes	No	No	7	7
157	1x40	2x61	Shared	7.36	2.94	No	No	No	No	5	7
158	1x42	7x47	Shared	5.12	5.12	No	No	No	No	6	7
159	1x43	2x57	Shared	4.87	4.87	No	No	Yes	Yes	6	7
160	1x43	2x58	Shared	7.22	10.11	No	No	No	No	6	9
161	1x47	2x51	Shared	7.5	2.14	No	No	Yes	No	5	7
162	1x50	2x50	Shared	5.39	13.46	No	No	Yes	No	9	9
163	1x57	2x44	Shared	6.43	11.79	Yes	Yes	Yes	No	6	5
164	1x58	1x59	Shared	11.8	7.87	No	No	No	No	3	5
165	1x59	1x60	Shared	4.53	7.92	No	No	No	Yes	5	5
166	2x40	I1.W83	Shared	4.94	12.36	No	No	Yes	Yes	7	6
167	2x44	I1.W83	Shared	12.03	14.03	Yes	No	Yes	Yes	5	6
168	2x39	3x49	Shared	9.28	7.95	Yes	No	No	No	7	8
169	2x42	3x45	Shared	10.75	5.38	Yes	Yes	No	No	7	6
170	2x42	3x46	Shared	4.84	3.63	Yes	Yes	No	Yes	7	8
171	2x42	4x42	Shared	5.34	2.67	Yes	Yes	No	No	7	8
172	2x42	4x45	Shared	9.67	6.04	Yes	Yes	No	No	7	5
173	2x45	3x42	Shared	14.5	10.87	No	No	Yes	Yes	9	7
174	2x45	4x46	Shared	5.96	7.45	No	No	No	No	9	7
175	2x45	4x50	Shared	10.17	11.3	No	No	No	Yes	9	9
176	2x51	2x55	Shared	6.09	7.31	Yes	No	No	No	7	5
177	2x53	3x32	Shared	7.22	14.44	Yes	Yes	Yes	No	7	7
178	2x53	3x35	Shared	13.96	4.65	Yes	Yes	No	No	7	8
179	2x56	3x28	Shared	8.5	4.25	No	No	No	Yes	6	4
180	2x56	3x31	Shared	4.56	10.64	No	No	No	No	6	4
181	2x62	E1x51	Shared	5.02	3.77	No	No	No	No	3	3
182	2x63	2x64	Shared	9.93	14.89	No	Yes	No	Yes	5	5
183	2x63	E1.T115	Shared	8.74	4.99	No	Yes	Yes	No	5	4
184	2x63	E1x50	Shared	10.61	11.58	No	Yes	Yes	Yes	5	8
185	E1x49	E2.T199	Shared	10.12	10.12	No	No	No	No	5	4
186	E1x50	E1x52	Shared	14.03	5.01	Yes	Yes	Yes	Yes	8	7
187	3x25	E1x50	Shared	5.22	7.84	No	No	Yes	Yes	9	8
188	3x28	E1x50	Shared	5.48	3.29	No	Yes	Yes	Yes	4	8
189	E1x50	E2x50	Shared	14.37	13.06	Yes	Yes	No	Yes	8	9
190	E1x51	E1x52	Shared	8.79	3.77	No	No	Yes	Yes	3	7
191	3x22	3x26	Shared	12.44	5.53	No	No	No	No	3	7
192	3x25	E2x50	Shared	7.28	7.28	No	No	No	Yes	9	9
193	3x29	E2x50	Shared	11.14	9.75	No	Yes	No	Yes	5	9
194	3x29	E2x52	Shared	17.87	13.1	No	Yes	No	Yes	5	6
195	3x30	4x61	Shared	8.53	19.49	Yes	No	No	No	6	5
196	3x32	3x33	Shared	9.05	3.39	Yes	No	No	No	7	5
197	3x33	4x60	Shared	7.95	3.98	No	No	No	No	5	4
198	3x33	E2x52	Shared	6.3	3.78	No	No	No	Yes	5	6
199	3x37	4x57	Shared	4.84	3.63	Yes	No	No	No	7	7
200	3x37	5x461	Shared	10.78	7.18	Yes	No	No	No	7	5
201	3x40	6x48	Shared	10.88	15.71	No	No	Yes	Yes	7	8
202	3x42	4x49	Shared	13.11	3.93	Yes	Yes	No	No	7	7
203	3x42	4x50	Shared	12.03	11.02	Yes	Yes	No	Yes	7	9
204	3x47	5x58	Shared	10.17	8.9	No	No	Yes	Yes	9	9
205	3x49	I2x57	Shared	18	12.86	No	No	No	No	8	8
206	3x51	3x55	Shared	7.57	7.57	Yes	Yes	No	No	7	7
207	3x51	3x56	Shared	5.96	6.95	Yes	Yes	No	Yes	7	6
208	3x51	5x57	Shared	5.38	8.06	Yes	Yes	No	No	7	6
209	3x51	5x60	Shared	8.21	8.21	Yes	Yes	No	No	7	4
210	3x52	I2x57	Shared	6.01	4.5	Yes	No	No	No	5	8
211	3x55	3x56	Shared	10.09	12.62	No	No	No	Yes	7	6
212	3x56	I2x52	Shared	5.97	9.55	No	Yes	No	No	6	5
213	4x38	4x41	Shared	8.39	1.4	No	No	No	No	6	4
214	4x58	4x59	Shared	5.34	5.34	No	No	No	No	4	8
215	4x59	5x39	Shared	15.3	13.91	No	No	Yes	Yes	8	5
216	4x60	5x39	Shared	4.84	9.67	No	No	Yes	Yes	4	5
217	4x63	5x35	Shared	6.36	3.82	Yes	No	No	No	4	1
218	4x63	5x36	Shared	16.88	8.94	Yes	No	Yes	Yes	4	4
219	4x63	5x39	Shared	4.96	5.96	Yes	No	Yes	Yes	4	5
220	E2.I200	E2.T192	Shared	4.56	4.56	No	No	No	No	4	5
221	E2.N197	E2.R195	Shared	4.82	7.23	No	No	Yes	Yes	4	1
222	E2.R195	E2.T201	Shared	10.35	9.06	Yes	Yes	No	Yes	1	3
223	E2.R195	Lig	Shared	8.35	11.32	Yes	Yes	Yes	Yes	1	0
224	E2.N197	E2.T199	Shared	13.16	14.62	No	No	No	No	4	4
225	E2.T201	E2x51	Shared	4.99	19.97	No	Yes	No	Yes	3	4
226	E2.S207	E2x51	Shared	6.36	1.27	No	No	No	Yes	5	4
227	7x38	E2x52	Shared	9.53	3.57	No	Yes	No	Yes	5	6
228	5x36	E2.T205	Shared	9.99	11.24	Yes	Yes	No	Yes	4	5
229	E2.T205	Lig	Shared	6.45	10.07	No	Yes	Yes	Yes	5	0
230	5x36	E2.T206	Shared	6.24	11.24	Yes	Yes	No	No	4	5
231	5x33	6x62	Shared	14.58	3.64	No	Yes	No	Yes	4	5
232	5x34	6x63	Shared	8.5	4.86	No	No	No	Yes	1	3
233	5x39	5x43	Shared	4.99	8.74	Yes	Yes	No	No	5	5
234	5x40	6x55	Shared	9.18	6.12	No	No	No	Yes	5	6
235	5x44	6x52	Shared	9.58	4.11	No	No	No	Yes	5	8
236	5x47	6x52	Shared	26.02	18.1	No	No	No	Yes	8	8
237	5x51	5x55	Shared	5.54	6.92	No	No	No	No	6	4
238	5x54	5x58	Shared	8.46	9.67	No	No	Yes	Yes	8	9
239	5x58	6x38	Shared	11.36	5.05	Yes	Yes	No	No	9	7
240	5x58	6x41	Shared	8.83	3.79	Yes	Yes	No	No	9	7
241	5x58	6x42	Shared	4.69	10.55	Yes	Yes	No	No	9	7
242	5x60	5x63	Shared	4.86	3.64	No	No	No	No	4	5
243	5x65	6x31	Shared	10.93	8.5	No	No	No	No	8	6
244	6x40	7x52	Shared	5.71	2.85	No	No	No	No	4	7
245	6x45	6x48	Shared	11.35	8.25	No	No	Yes	Yes	9	8
246	6x54	7x33	Shared	6.02	3.01	No	Yes	No	No	5	4
247	6x54	7x37	Shared	9.03	4.52	No	Yes	No	No	5	7
248	6x58	7x30	Shared	4.43	4.43	No	No	No	No	4	4
249	6x58	7x34	Shared	17.44	8.14	No	No	No	Yes	4	4
250	6x60	6x64	Shared	10.72	9.53	No	No	No	No	4	1
251	6x62	Lig	Shared	24.29	10.56	No	Yes	Yes	Yes	5	0
252	E3.P293	E3.T292	Shared	5.25	3.5	No	No	No	No	1	2
253	7x26	7x30	Shared	5.24	7.87	No	No	No	No	1	4
254	7x31	7x35	Shared	11.27	19.16	Yes	No	No	Yes	4	5
255	7x31	Lig	Shared	11.72	10.92	Yes	No	Yes	Yes	4	0
256	7x34	7x38	Shared	12.35	14.4	No	Yes	No	Yes	4	5
257	7x35	7x38	Shared	9.35	8.18	No	Yes	No	Yes	5	5
258	7x45	7x49	Shared	6.81	10.77	No	No	No	No	9	9
259	E2.G193	E2x51	Shared	4.35	2.9	No	No	No	Yes	2	4
260	3x22	E2.T192	Shared	4.34	8.67	No	No	No	No	3	5
261	3x27	3x31	Shared	4.28	4.28	No	No	No	No	4	4
262	5x33	6x63	Shared	4.15	4.15	No	Yes	No	Yes	4	3
263	6x32	6x36	Shared	4.12	8.23	No	No	No	No	5	6
264	1x55	1x59	Shared	4.01	12.03	No	No	No	No	3	5
265	1x56	1x60	Shared	3.94	6.57	No	Yes	No	Yes	7	5
266	3x30	4x57	Shared	3.77	5.02	Yes	No	No	No	6	7
267	5x47	6x49	Shared	3.77	6.28	No	No	No	Yes	8	5
268	1x57	I1.M80	Shared	3.73	6.22	Yes	Yes	No	No	6	5
269	5x49	5x50	Shared	3.53	3.53	No	No	No	No	6	9
270	3x44	5x50	Shared	3.5	5.25	No	No	No	No	8	9
271	6x49	6x50	Shared	3.39	5.08	No	Yes	No	No	5	9
272	3x52	I2x53	Shared	3.26	3.26	Yes	No	No	No	5	5
273	4x56	5x461	Shared	3.22	3.22	No	No	No	No	4	5
274	6x53	6x54	Shared	3.04	1.52	No	No	No	Yes	6	5
275	3x41	4x49	Shared	2.98	4.47	No	No	No	No	5	7
276	5x65	6x35	Shared	2.85	5.71	No	No	No	No	8	6
277	2x46	3x43	Shared	2.77	5.54	No	No	No	Yes	9	8
278	6x51	7x41	Shared	2.77	5.55	No	No	No	No	7	7
279	1x54	2x44	Shared	2.51	2.51	No	No	Yes	No	7	5
280	3x24	E1x52	Shared	2.49	6.22	No	No	Yes	Yes	5	7
281	E2.E209	E2.Y210	Shared	2.24	1.12	No	No	No	No	3	4
282	5x63	5x67	Shared	2.06	5.14	No	No	No	No	5	5
283	1x46	7x47	Shared	1.96	1.96	No	No	No	No	8	7
284	3x52	3x53	Shared	1.86	3.71	Yes	No	No	No	5	7
285	3x38	4x53	Shared	1.84	3.68	No	No	No	No	6	7
286	1x48	1x49	Shared	1.71	1.71	No	No	No	No	4	6
287	3x54	5x64	Shared	1.7	1.7	No	No	No	No	8	5
288	3x55	5x64	Shared	1.7	1.7	No	No	No	No	7	5
289	3x23	3x24	Shared	1.61	1.61	No	No	No	No	1	5
290	6x44	7x48	Shared	1.6	1.6	No	No	No	No	6	5
291	6x43	6x461	Shared	1.59	1.59	No	No	No	No	4	6
292	5x41	5x45	Shared	1.52	1.52	No	No	No	No	4	5
293	6x39	6x43	Shared	1.52	1.52	No	No	No	No	4	4
294	E3.Q291	NT.K41	p2y1_on	0	9.49	No	No	No	No	2	1
295	E2.K196	NT.A43	p2y1_on	0	4.82	No	No	No	No	2	4
296	7x28	NT.K46	p2y1_on	0	12.44	No	No	No	No	2	4
297	7x28	NT.T47	p2y1_on	0	11.56	No	No	No	No	2	2
298	1x30	1x34	p2y1_on	0	5.16	No	No	No	No	4	5
299	1x31	7x32	p2y1_on	0	4.55	No	No	No	No	4	3
300	1x31	7x36	p2y1_on	0	5.73	No	No	No	No	4	5
301	1x32	2x64	p2y1_on	0	4.13	No	No	No	Yes	3	5
302	1x32	7x31	p2y1_on	0	13.41	No	No	Yes	No	3	4
303	1x35	7x35	p2y1_on	0	3.99	No	Yes	No	Yes	6	5
304	1x42	7x42	p2y1_on	0	4.85	No	No	No	No	6	7
305	1x43	2x54	p2y1_on	0	3.93	No	No	No	No	6	5
306	1x50	2x51	p2y1_on	0	7.25	No	No	Yes	No	9	7
307	1x55	1x56	p2y1_on	0	4.65	No	No	No	Yes	3	7
308	1x55	1x60	p2y1_on	0	5.29	No	No	No	Yes	3	5
309	1x56	7x54	p2y1_on	0	4.98	No	Yes	No	Yes	7	6
310	1x56	8x54	p2y1_on	0	8.48	No	Yes	No	No	7	0
311	1x57	I1.W83	p2y1_on	0	8.02	Yes	Yes	Yes	Yes	6	6
312	1x57	2x43	p2y1_on	0	3.73	Yes	Yes	Yes	No	6	8
313	1x60	8x57	p2y1_on	0	4.39	No	Yes	No	No	5	0
314	I1.M80	I1.W83	p2y1_on	0	3.49	No	No	Yes	Yes	5	6
315	8x53	I1.M80	p2y1_on	0	8.69	No	No	No	No	5	5
316	2x41	I1.W83	p2y1_on	0	4.9	No	No	Yes	Yes	6	6
317	2x37	2x38	p2y1_on	0	3.71	No	No	No	No	7	6
318	2x39	3x46	p2y1_on	0	4.42	Yes	No	No	Yes	7	8
319	2x41	4x39	p2y1_on	0	4.55	No	No	No	No	6	3
320	2x42	3x49	p2y1_on	0	6.53	Yes	Yes	No	No	7	8
321	2x43	8x50	p2y1_on	0	3.73	Yes	No	No	No	8	8
322	2x46	3x42	p2y1_on	0	4.87	No	No	Yes	Yes	9	7
323	2x50	7x50	p2y1_on	0	14.49	Yes	No	No	No	9	9
324	2x52	3x35	p2y1_on	0	9.61	No	No	No	No	7	8
325	2x53	2x57	p2y1_on	0	3.52	Yes	Yes	Yes	Yes	7	7
326	2x53	3x36	p2y1_on	0	10.55	Yes	Yes	No	No	7	7
327	2x59	3x28	p2y1_on	0	4.55	No	No	No	Yes	6	4
328	2x60	3x29	p2y1_on	0	9.72	No	No	No	Yes	7	5
329	2x60	3x32	p2y1_on	0	4.87	No	No	Yes	No	7	7
330	2x63	E2x50	p2y1_on	0	6.72	No	Yes	No	Yes	5	9
331	2x63	Lig	p2y1_on	0	8.74	No	Yes	Yes	Yes	5	0
332	2x64	7x38	p2y1_on	0	6.17	No	Yes	No	Yes	5	5
333	2x64	Lig	p2y1_on	0	8.01	No	Yes	Yes	Yes	5	0
334	2x66	E1.K114	p2y1_on	0	16.79	No	No	No	No	4	3
335	E1.K114	E1x49	p2y1_on	0	11.06	No	No	No	No	3	5
336	E1.T115	E2.T201	p2y1_on	0	4.71	Yes	No	No	Yes	4	3
337	3x24	E1x50	p2y1_on	0	3.49	No	No	Yes	Yes	5	8
338	3x25	E2.T192	p2y1_on	0	3.38	No	No	No	No	9	5
339	3x26	4x64	p2y1_on	0	6.12	No	No	No	No	7	5
340	3x28	3x31	p2y1_on	0	8.23	No	Yes	No	No	4	4
341	3x29	Lig	p2y1_on	0	4.53	No	Yes	Yes	Yes	5	0
342	3x34	4x57	p2y1_on	0	7.68	No	No	No	No	5	7
343	3x43	6x45	p2y1_on	0	3.65	No	Yes	No	No	8	9
344	3x43	7x49	p2y1_on	0	4.07	No	Yes	No	No	8	9
345	3x43	7x53	p2y1_on	0	4.69	No	Yes	Yes	Yes	8	9
346	3x46	3x50	p2y1_on	0	7.52	No	Yes	Yes	No	8	9
347	3x46	7x53	p2y1_on	0	6.04	No	Yes	Yes	Yes	8	9
348	3x47	5x57	p2y1_on	0	5.16	No	No	No	No	9	6
349	3x50	7x53	p2y1_on	0	9.26	Yes	No	Yes	Yes	9	9
350	3x54	5x61	p2y1_on	0	4.61	No	No	No	No	8	7
351	I2x53	I2x56	p2y1_on	0	3.95	No	No	No	No	5	4
352	4x40	4x43	p2y1_on	0	5.82	No	No	No	No	5	4
353	4x46	4x50	p2y1_on	0	6.18	No	No	No	Yes	7	9
354	4x60	5x36	p2y1_on	0	3.63	No	No	Yes	Yes	4	4
355	4x64	E2.G191	p2y1_on	0	3.71	No	No	No	No	5	4
356	E2.K196	E2.R195	p2y1_on	0	17.33	No	No	Yes	Yes	2	1
357	E2.R195	E2x51	p2y1_on	0	9.26	Yes	Yes	No	Yes	1	4
358	E2.T201	Lig	p2y1_on	0	3.66	No	Yes	Yes	Yes	3	0
359	E2x51	Lig	p2y1_on	0	10.19	No	Yes	Yes	Yes	4	0
360	E2.T205	E2x52	p2y1_on	0	10.12	No	Yes	No	Yes	5	6
361	E2x52	Lig	p2y1_on	0	14.33	No	Yes	Yes	Yes	6	0
362	E2.T205	E2.T206	p2y1_on	0	4.71	No	Yes	No	No	5	5
363	5x33	E2.T206	p2y1_on	0	4.42	No	Yes	No	No	4	5
364	E2.E209	E2.S207	p2y1_on	0	11.5	No	No	No	No	3	5
365	5x34	5x37	p2y1_on	0	10.69	No	No	No	No	1	4
366	5x34	5x38	p2y1_on	0	10.02	No	No	No	No	1	3
367	5x36	5x40	p2y1_on	0	3.82	Yes	Yes	No	No	4	5
368	5x37	6x59	p2y1_on	0	8.53	No	No	No	No	4	4
369	5x37	6x63	p2y1_on	0	4.87	No	No	No	Yes	4	3
370	5x44	6x55	p2y1_on	0	6.01	No	No	No	Yes	5	6
371	5x47	5x51	p2y1_on	0	8.53	No	No	No	No	8	6
372	5x51	6x49	p2y1_on	0	7.14	No	No	No	Yes	6	5
373	5x54	6x45	p2y1_on	0	6.28	No	No	No	No	8	9
374	5x55	6x42	p2y1_on	0	4.15	No	No	No	No	4	7
375	5x58	5x61	p2y1_on	0	3.63	Yes	Yes	No	No	9	7
376	5x61	6x38	p2y1_on	0	6.14	No	No	No	No	7	7
377	5x65	6x34	p2y1_on	0	6.01	No	No	No	No	8	7
378	5x66	5x67	p2y1_on	0	6.04	No	No	No	No	3	5
379	6x29	6x31	p2y1_on	0	8.65	No	No	No	No	4	6
380	6x30	6x32	p2y1_on	0	8.5	No	No	No	No	4	5
381	6x41	7x53	p2y1_on	0	5.05	No	No	Yes	Yes	7	9
382	6x44	7x45	p2y1_on	0	8.87	No	No	No	No	6	9
383	6x47	6x48	p2y1_on	0	6.36	No	No	Yes	Yes	8	8
384	6x47	7x45	p2y1_on	0	10.43	No	No	No	No	8	9
385	6x48	6x52	p2y1_on	0	4.36	Yes	Yes	No	Yes	8	8
386	6x48	7x46	p2y1_on	0	3.82	Yes	Yes	No	No	8	9
387	6x51	6x52	p2y1_on	0	10.18	No	No	No	Yes	7	8
388	6x51	7x34	p2y1_on	0	4.13	No	No	No	Yes	7	4
389	6x55	6x59	p2y1_on	0	5.64	No	Yes	No	No	6	4
390	6x55	7x34	p2y1_on	0	8.36	No	Yes	No	Yes	6	4
391	6x58	6x62	p2y1_on	0	9.64	No	No	No	Yes	4	5
392	6x61	E3.F290	p2y1_on	0	5.55	No	No	No	No	1	3
393	6x62	E3.Q291	p2y1_on	0	10.51	No	Yes	No	No	5	2
394	7x26	E3.F290	p2y1_on	0	5.36	No	No	No	No	1	3
395	7x27	E3.F290	p2y1_on	0	6.04	No	No	No	No	2	3
396	7x26	7x29	p2y1_on	0	10.69	No	No	No	No	1	2
397	7x34	7x35	p2y1_on	0	5.64	No	Yes	No	Yes	4	5
398	7x34	7x37	p2y1_on	0	3.75	No	Yes	No	No	4	7
399	7x40	7x43	p2y1_on	0	4.15	No	No	No	No	7	5
400	7x54	7x55	p2y1_on	0	3.65	No	Yes	No	No	6	6
401	7x54	8x50	p2y1_on	0	4.29	No	Yes	No	No	6	8
402	7x54	8x54	p2y1_on	0	4.87	No	Yes	No	No	6	0
403	8x47	8x51	p2y1_on	0	7.51	No	No	No	No	8	8
404	8x48	8x49	p2y1_on	0	5.78	No	No	No	No	5	6
405	8x52	8x55	p2y1_on	0	7.91	No	No	No	No	5	0
406	I1.K81	I1.P82	p2y1_on	0	3.35	No	No	No	No	6	5
407	1x35	1x36	p2y1_on	0	3.28	No	Yes	No	No	6	6
408	2x46	7x50	p2y1_on	0	3.28	No	No	No	No	9	9
409	2x37	2x40	p2y1_on	0	3.26	No	No	No	No	7	7
410	3x39	7x46	p2y1_on	0	3.26	No	No	No	No	9	9
411	5x62	6x38	p2y1_on	0	3.21	No	No	No	No	5	7
412	8x52	8x59	p2y1_on	0	3.2	No	No	No	No	5	0
413	2x37	2x39	p2y1_on	0	3.1	No	No	Yes	No	7	7
414	4x49	4x52	p2y1_on	0	3.07	No	No	No	No	7	5
415	5x62	6x39	p2y1_on	0	3.07	No	No	No	No	5	4
416	5x68	I3.S252	p2y1_on	0	3.06	No	No	No	No	4	0
417	6x41	7x52	p2y1_on	0	2.98	No	No	No	No	7	7
418	3x34	3x35	p2y1_on	0	2.96	No	No	No	No	5	8
419	3x44	5x53	p2y1_on	0	2.95	No	No	No	No	8	6
420	1x45	7x51	p2y1_on	0	2.94	No	No	No	No	5	6
421	5x66	6x35	p2y1_on	0	2.94	No	No	No	No	3	6
422	1x44	1x48	p2y1_on	0	2.85	No	No	No	No	5	4
423	2x57	2x61	p2y1_on	0	2.85	Yes	Yes	No	No	7	7
424	6x37	6x40	p2y1_on	0	2.85	No	No	No	No	7	4
425	4x41	4x45	p2y1_on	0	2.83	No	No	No	No	4	5
426	2x49	3x42	p2y1_on	0	2.77	No	No	Yes	Yes	8	7
427	Lig	NT.T45	p2y1_on	0	2.75	Yes	Yes	No	No	0	3
428	5x33	E2.D208	p2y1_on	0	2.71	No	Yes	No	No	4	3
429	6x63	6x64	p2y1_on	0	2.71	No	Yes	No	No	3	1
430	8x49	8x50	p2y1_on	0	2.59	No	No	No	No	6	8
431	7x39	7x42	p2y1_on	0	1.86	No	No	No	No	4	7
432	1x49	1x52	p2y1_on	0	1.84	No	No	No	No	6	5
433	5x59	5x62	p2y1_on	0	1.84	No	No	No	No	3	5
434	6x29	I3.S252	p2y1_on	0	1.78	No	No	No	No	4	0
435	1x45	1x46	p2y1_on	0	1.76	No	No	No	No	5	8
436	3x38	3x41	p2y1_on	0	1.71	No	No	No	No	6	5
437	5x48	5x52	p2y1_on	0	1.71	No	No	No	No	4	3
438	5x55	5x56	p2y1_on	0	1.71	No	No	No	No	4	3
439	7x32	NT.T47	p2y1_on	0	1.68	No	No	No	No	3	2
440	E3.A294	E3.T292	p2y1_on	0	1.68	No	No	No	No	3	2
441	1x51	1x52	p2y1_on	0	1.62	No	No	No	No	3	5
442	1x54	2x47	p2y1_on	0	1.62	No	No	No	No	7	9
443	4x40	4x44	p2y1_on	0	1.62	No	No	No	No	5	3
444	5x41	5x42	p2y1_on	0	1.62	No	No	No	No	4	3
445	6x46	6x49	p2y1_on	0	1.62	No	No	No	Yes	5	5
446	6x33	7x56	p2y1_on	0	1.61	No	No	No	No	8	6
447	3x34	4x54	p2y1_on	0	1.6	No	No	No	No	5	4
448	6x37	7x56	p2y1_on	0	1.58	No	No	No	No	7	6
449	4x43	4x47	p2y1_on	0	1.54	No	No	No	No	4	4
450	3x40	3x44	p2y1_on	0	1.52	No	No	No	No	7	8
451	3x21	E1x52	p2y1_on	0	1.51	No	No	Yes	Yes	6	7
452	I3.L249	I3.S252	p2y1_on	0	1.5	No	No	No	No	0	0
453	6x47	7x40	p2y1_on	0	1.5	No	No	No	No	8	7
454	6x55	6x56	p2y1_on	0	1.5	No	Yes	No	No	6	5
455	8x54	8x58	p2y1_on	0	1.47	No	No	No	No	0	0
456	5x38	5x41	p2y1_on	0	1.46	No	No	No	No	3	4
457	6x54	6x57	p2y1_on	0	1.44	No	Yes	No	No	5	5
458	1x53	7x54	p2y1_on	0	1.39	No	No	No	Yes	8	6
459	3x56	I2x50	p2y1_on	0	1.39	No	Yes	No	No	6	8
460	I2x51	I2x54	p2y1_on	0	1.38	No	No	No	No	5	5
461	4x58	4x62	p2y1_on	0	1.32	No	No	No	No	4	4
462	8x58	8x59	p2y1_on	0	1.29	No	No	No	No	0	0
463	1x38	1x39	p2y1_on	0	1.26	No	No	Yes	Yes	4	7
464	1x47	1x48	p2y1_on	0	1.22	No	No	No	No	5	4
465	7x55	8x51	p2y1_on	0	1.21	No	No	No	No	6	8
466	2x48	4x50	p2y1_on	0	1.14	No	No	No	Yes	5	9
467	8x52	8x56	p2y1_on	0	1.07	No	No	No	No	5	0

Orange: nodes, hubs and links specific of p2y1_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of p2y1_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	p2y1_off Avg Int. Strength	p2y1_on Avg Int. Strength	p2y1_off Num Of Links	p2y1_on Num Of Links	ConSurf
1	2x39	p2y1_off	7.63	5.15667	4	3	7
2	2x43	p2y1_off	3.966	3.73	5	2	8
3	2x44	p2y1_off	6.198	9.44333	5	3	5
4	2x50	p2y1_off	7.29	13.975	4	2	9
5	2x51	p2y1_off	4.772	5.56667	5	3	7
6	E1.T115	p2y1_off	7.0275	4.53	4	3	4
7	3x30	p2y1_off	5.37	12.255	4	2	6
8	3x32	p2y1_off	5.8325	7.56667	4	3	7
9	3x37	p2y1_off	8.46	5.405	5	2	7
10	3x50	p2y1_off	6.5675	8.39	4	2	9
11	3x52	p2y1_off	4.308	3.82333	5	3	5
12	4x63	p2y1_off	8.832	6.24	5	3	4
13	7x31	p2y1_off	12.975	14.4967	4	3	4
14	1x39	Shared	7.29167	4.86	6	4	7
15	1x57	Shared	5.15	7.44	4	4	6
16	I1.W83	Shared	9.1725	8.56	4	5	6
17	2x42	Shared	7.65	4.85	4	5	7
18	2x53	Shared	8.1575	8.29	4	4	7
19	2x57	Shared	4.2525	3.9825	4	4	7
20	E1x50	Shared	8.75333	7.37833	6	6	8
21	E1x52	Shared	6.966	4.1275	5	4	7
22	3x42	Shared	11.23	6.692	4	5	7
23	3x51	Shared	5.76167	7.6975	6	4	7
24	E2.R195	Shared	7.55	10.84	5	5	1
25	5x36	Shared	8.516	7.774	5	5	4
26	5x39	Shared	7.5225	9.57	4	4	5
27	5x58	Shared	8.62	6.93167	6	6	9
28	6x48	Shared	9.7275	7.7	4	5	8
29	7x53	Shared	4.945	6.26	6	4	9
30	Lig	Shared	10.8278	8.64364	9	11	0
31	1x35	p2y1_on	10.6733	4.1625	3	4	6
32	1x56	p2y1_on	2.73	6.17	2	4	7
33	1x60	p2y1_on	3.2	6.0425	3	4	5
34	2x63	p2y1_on	9.76	9.384	3	5	5
35	2x64	p2y1_on	7.9	7.344	3	5	5
36	3x28	p2y1_on	6.43333	5.08	3	4	4
37	3x29	p2y1_on	11.4267	9.275	3	4	5
38	3x43	p2y1_on	2.77	4.4875	1	4	8
39	3x46	p2y1_on	4.605	5.4025	2	4	8
40	3x56	p2y1_on	7.34	7.6275	3	4	6
41	4x50	p2y1_on	8.69667	7.41	3	4	9
42	E2.T201	p2y1_on	7.67	9.35	2	4	3
43	E2x50	p2y1_on	10.93	9.2025	3	4	9
44	E2x51	p2y1_on	5.23333	8.718	3	5	4
45	E2x52	p2y1_on	11.2333	8.98	3	5	6
46	E2.T205	p2y1_on	7.63667	9.035	3	4	5
47	5x33	p2y1_on	9.365	3.73	2	4	4
48	6x49	p2y1_on	3.58	5.03	2	4	5
49	6x52	p2y1_on	14.4067	9.1875	3	4	8
50	6x54	p2y1_on	6.03	2.6225	3	4	5
51	6x55	p2y1_on	6.98	5.526	2	5	6
52	6x62	p2y1_on	15.1133	8.5875	3	4	5
53	6x63	p2y1_on	6.325	4.1475	2	4	3
54	7x34	p2y1_on	11.3967	7.40333	3	6	4
55	7x35	p2y1_on	12.8467	8.93	3	5	5
56	7x38	p2y1_on	10.41	8.08	3	4	5
57	7x54	p2y1_on	0	3.836	0	5	6

Orange: nodes, hubs and links specific of p2y1_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of p2y1_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	p2y1_off Recurrence	p2y1_on Recurrence	p2y1_off Hub1?	p2y1_on Hub1?	p2y1_off Hub2?	p2y1_on Hub2?	ConSurf1	ConSurf2
1	7x23	7x27	p2y1_off	12.2104	0	No	No	No	No	4	2
2	7x26	7x27	p2y1_off	14.3635	0	No	No	No	No	1	2
3	7x26	7x30	p2y1_off	15.4323	6.23047	No	No	No	No	1	4
4	6x58	7x30	p2y1_off	17.5543	7.45768	No	No	No	No	4	4
5	E1.T115	E2.R195	p2y1_off	10.2934	0	Yes	No	Yes	Yes	4	1
6	1x35	2x64	p2y1_off	17.6762	4.88932	No	Yes	No	Yes	6	5
7	2x63	E1.T115	p2y1_off	20.0809	1.20443	No	Yes	Yes	No	5	4
8	2x60	3x28	p2y1_off	14.4855	0	No	No	No	Yes	7	4
9	3x28	E1x50	p2y1_off	13.1832	4.97396	No	Yes	Yes	Yes	4	8
10	2x53	7x42	p2y1_off	41.5757	0	Yes	Yes	No	No	7	7
11	1x57	2x44	p2y1_off	22.7918	0.240885	Yes	Yes	Yes	No	6	5
12	1x57	7x53	p2y1_off	29.7076	0	Yes	Yes	Yes	Yes	6	9
13	7x49	7x53	p2y1_off	88.2669	0	No	No	Yes	Yes	9	9
14	2x50	7x49	p2y1_off	100	0	Yes	No	No	No	9	9
15	2x50	3x35	p2y1_off	51.4747	0	Yes	No	No	No	9	8
16	2x50	7x46	p2y1_off	51.1531	0	Yes	No	No	No	9	9
17	2x53	7x46	p2y1_off	51.2439	0	Yes	Yes	No	No	7	9
18	1x58	2x44	p2y1_off	10.5113	0	No	No	Yes	No	3	5
19	2x39	2x43	p2y1_off	41.5186	0	Yes	No	Yes	No	7	8
20	2x43	7x53	p2y1_off	62.1806	0	Yes	No	Yes	Yes	8	9
21	2x39	3x49	p2y1_off	20.5142	7.42188	Yes	No	No	No	7	8
22	2x39	3x50	p2y1_off	22.5687	0	Yes	No	Yes	No	7	9
23	2x41	4x42	p2y1_off	11.3596	0	No	No	No	No	6	8
24	2x42	4x42	p2y1_off	12.4672	1.2793	Yes	Yes	No	No	7	8
25	2x43	3x46	p2y1_off	16.7449	0	Yes	No	No	Yes	8	8
26	2x41	4x46	p2y1_off	10.2467	0	No	No	No	No	6	7
27	3x37	5x43	p2y1_off	21.2846	0	Yes	No	No	No	7	5
28	5x39	5x43	p2y1_off	22.1925	2.05078	Yes	Yes	No	No	5	5
29	4x63	5x39	p2y1_off	12.3765	4.19271	Yes	No	Yes	Yes	4	5
30	3x33	4x60	p2y1_off	28.2316	3.72396	No	No	No	No	5	4
31	3x40	6x48	p2y1_off	13.3959	5.85612	No	No	Yes	Yes	7	8
32	6x48	7x45	p2y1_off	19.8552	0	Yes	Yes	No	No	8	9
33	7x45	7x49	p2y1_off	20.9136	3.10221	No	No	No	No	9	9
34	3x40	5x50	p2y1_off	12.3012	0	No	No	No	No	7	9
35	3x50	6x30	p2y1_off	16.2313	0	Yes	No	No	No	9	4
36	3x51	3x52	p2y1_off	12.8745	0	Yes	Yes	Yes	No	7	5
37	3x52	I2x57	p2y1_off	17.243	8.66862	Yes	No	No	No	5	8
38	3x54	6x30	p2y1_off	15.1859	0	No	No	No	No	8	4
39	3x54	5x65	p2y1_off	12.0081	0	No	No	No	No	8	8
40	1x39	7x42	p2y1_off	40.9271	6.60482	Yes	Yes	No	No	7	7
41	7x34	Lig	p2y1_off	14.4906	0	No	Yes	Yes	Yes	4	0
42	4x60	5x39	p2y1_off	29.1707	6.29232	No	No	Yes	Yes	4	5
43	1x39	2x60	p2y1_off	14.8901	0	Yes	Yes	No	No	7	7
44	E2.R195	Lig	Shared	11.274	20.7129	Yes	Yes	Yes	Yes	1	0
45	2x63	2x64	Shared	16.7501	18.5742	No	Yes	No	Yes	5	5
46	7x34	7x38	Shared	26.9164	48.7533	No	Yes	No	Yes	4	5
47	6x58	7x34	Shared	11.9484	17.8092	No	No	No	Yes	4	4
48	1x35	1x39	Shared	19.0848	19.8763	No	Yes	Yes	Yes	6	7
49	1x39	2x57	Shared	10.9964	13.0208	Yes	Yes	Yes	Yes	7	7
50	2x53	3x32	Shared	66.064	13.5872	Yes	Yes	Yes	No	7	7
51	3x32	3x33	Shared	64.7643	11.569	Yes	No	No	No	7	5
52	3x33	E2x52	Shared	37.1034	12.6107	No	No	No	Yes	5	6
53	7x38	E2x52	Shared	31.8426	23.7467	No	Yes	No	Yes	5	6
54	2x53	3x35	Shared	51.6563	17.2493	Yes	Yes	No	No	7	8
55	2x42	3x46	Shared	15.754	12.7376	Yes	Yes	No	Yes	7	8
56	3x49	I2x57	Shared	18.3533	10.8203	No	No	No	No	8	8
57	6x62	Lig	p2y1_on	4.00529	16.8327	No	Yes	Yes	Yes	5	0
58	7x31	7x35	p2y1_on	2.84832	11.5592	Yes	No	No	Yes	4	5
59	7x31	Lig	p2y1_on	0.900153	10.4134	Yes	No	Yes	Yes	4	0
60	7x34	7x35	p2y1_on	0	30.7227	No	Yes	No	Yes	4	5
61	6x58	6x62	p2y1_on	0	15.5664	No	No	No	Yes	4	5
62	2x64	Lig	p2y1_on	0	11.0059	No	Yes	Yes	Yes	5	0
63	1x50	2x50	p2y1_on	4.5734	11.276	No	No	Yes	No	9	9
64	2x50	7x50	p2y1_on	0	12.4967	Yes	No	No	No	9	9
65	2x46	7x50	p2y1_on	0	13.7109	No	No	No	No	9	9
66	2x46	3x43	p2y1_on	1.14919	28.903	No	No	No	Yes	9	8
67	3x43	6x45	p2y1_on	0	69.6517	No	Yes	No	No	8	9
68	6x45	6x48	p2y1_on	3.43718	94.0625	No	No	Yes	Yes	9	8
69	6x48	6x52	p2y1_on	0	100	Yes	Yes	No	Yes	8	8
70	6x51	6x52	p2y1_on	0	89.5833	No	No	No	Yes	7	8
71	6x51	7x34	p2y1_on	0	90.0326	No	No	No	Yes	7	4
72	1x50	2x51	p2y1_on	0	10.0488	No	No	Yes	No	9	7
73	7x54	8x50	p2y1_on	0	21.1556	No	Yes	No	No	6	8
74	2x43	8x50	p2y1_on	0	24.2253	Yes	No	No	No	8	8
75	1x57	2x43	p2y1_on	0	25.2702	Yes	Yes	Yes	No	6	8
76	1x57	I1.W83	p2y1_on	0	25.8431	Yes	Yes	Yes	Yes	6	6
77	2x40	I1.W83	p2y1_on	6.31664	34.0137	No	No	Yes	Yes	7	6
78	2x37	2x40	p2y1_on	0	34.9902	No	No	No	No	7	7
79	2x37	2x39	p2y1_on	0	36.9238	No	No	Yes	No	7	7
80	2x39	3x46	p2y1_on	0	42.6009	Yes	No	No	Yes	7	8
81	3x46	7x53	p2y1_on	0	54.6582	No	Yes	Yes	Yes	8	9
82	3x43	7x53	p2y1_on	0	56.4681	No	Yes	Yes	Yes	8	9
83	2x46	3x42	p2y1_on	0	14.9186	No	No	Yes	Yes	9	7
84	E2x52	Lig	p2y1_on	0	11.6146	No	Yes	Yes	Yes	6	0
85	2x63	E1x50	p2y1_on	5.04293	16.3672	No	Yes	Yes	Yes	5	8
86	2x64	7x38	p2y1_on	0	26.3607	No	Yes	No	Yes	5	5
87	E2.N197	E2.T199	p2y1_on	0.0207528	10.5827	No	No	No	No	4	4
88	E2.N197	E2.R195	p2y1_on	1.65763	13.2129	No	No	Yes	Yes	4	1
89	3x25	E2x50	p2y1_on	4.96251	11.709	No	No	No	Yes	9	9
90	3x22	E2.T192	p2y1_on	3.60839	10.1921	No	No	No	No	3	5
91	3x25	E2.T192	p2y1_on	0	15.2507	No	No	No	No	9	5
92	3x34	4x57	p2y1_on	0	10.4264	No	No	No	No	5	7
93	3x34	3x35	p2y1_on	0	13.8509	No	No	No	No	5	8
94	3x47	5x58	p2y1_on	0.0103764	22.6367	No	No	Yes	Yes	9	9
95	5x54	5x58	p2y1_on	5.61104	30.1107	No	No	Yes	Yes	8	9
96	5x54	6x45	p2y1_on	0	30.8268	No	No	No	No	8	9
97	3x47	5x57	p2y1_on	0	21.4941	No	No	No	No	9	6
98	3x51	5x57	p2y1_on	1.23479	20.3516	Yes	Yes	No	No	7	6
99	3x51	5x60	p2y1_on	3.694	14.6647	Yes	Yes	No	No	7	4
100	E2x51	Lig	p2y1_on	0	13.0339	No	Yes	Yes	Yes	4	0
101	5x44	6x55	p2y1_on	0	15	No	No	No	Yes	5	6
102	5x58	6x41	p2y1_on	1.144	15.0781	Yes	Yes	No	No	9	7
103	6x41	7x53	p2y1_on	0	16.1686	No	No	Yes	Yes	7	9
104	5x60	5x63	p2y1_on	2.46699	13.4701	No	No	No	No	4	5
105	5x63	5x67	p2y1_on	1.23479	12.2689	No	No	No	No	5	5
106	5x66	5x67	p2y1_on	0	11.0612	No	No	No	No	3	5
107	1x35	7x35	p2y1_on	0	18.0241	No	Yes	No	Yes	6	5
108	5x44	6x52	p2y1_on	1.01948	14.7038	No	No	No	Yes	5	8

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
E3.Q291	NT.C42	Shared	6.1	3.05	0	0	1	2
7x31	NT.L44	p2y1_off	18.76	0	1	0	1	1
Lig	NT.L44	p2y1_off	19.89	0	1	1	0	1
7x28	NT.T45	p2y1_off	8.67	0	0	0	2	1
1x32	NT.K46	p2y1_off	7.44	0	1	0	2	1
E1.T115	NT.K46	p2y1_off	9.01	0	1	0	2	1
Lig	NT.K46	p2y1_off	5.29	0	1	1	0	1
1x31	7x31	p2y1_off	10.15	0	1	0	2	1
1x31	7x35	Shared	17.92	7.68	1	0	2	2
1x32	E1.T115	Shared	5.19	3.89	1	0	2	2
1x35	2x64	Shared	8.21	3.52	0	0	2	1
1x36	2x64	p2y1_off	5.56	0	0	0	2	1
2x63	2x64	Shared	9.93	14.89	0	1	1	1
2x63	E1.T115	Shared	8.74	4.99	0	1	1	2
2x63	E1x50	Shared	10.61	11.58	0	1	1	2
E1.T115	E2.R195	p2y1_off	5.17	0	1	0	2	1
E1x50	E2x50	Shared	14.37	13.06	2	1	2	2
3x29	4x64	p2y1_off	5.27	0	0	1	1	2
3x29	E2x50	Shared	11.14	9.75	0	1	1	2
3x29	E2x52	Shared	17.87	13.1	0	1	1	1
3x33	E2x52	Shared	6.3	3.78	0	0	2	1
E2.N197	E2.R195	Shared	4.82	7.23	1	0	2	1
E2.R195	E2.T199	p2y1_off	9.06	0	1	1	1	2
E2.R195	E2.T201	Shared	10.35	9.06	1	1	1	1
E2.R195	Lig	Shared	8.35	11.32	1	1	1	0
E2.N197	E2.T199	Shared	13.16	14.62	1	0	2	2
E2.T201	E2x51	Shared	4.99	19.97	0	1	1	1
E2.S207	E2x51	Shared	6.36	1.27	0	0	2	1
7x38	E2x52	Shared	9.53	3.57	0	1	2	1
5x36	E2.T205	Shared	9.99	11.24	1	1	2	1
6x62	E2.T205	p2y1_off	6.47	0	1	0	1	1
E2.T205	Lig	Shared	6.45	10.07	1	1	1	0
5x36	E2.T206	Shared	6.24	11.24	1	1	2	2
5x33	6x62	Shared	14.58	3.64	0	0	2	1
5x36	6x55	p2y1_off	4.78	0	1	1	2	2
6x58	7x30	Shared	4.43	4.43	1	0	1	2
6x58	7x34	Shared	17.44	8.14	1	0	1	1
6x58	Lig	p2y1_off	13.73	0	1	0	1	0
6x62	Lig	Shared	24.29	10.56	1	0	1	0
7x31	7x35	Shared	11.27	19.16	1	0	1	2
7x31	Lig	Shared	11.72	10.92	1	0	1	0
7x34	7x38	Shared	12.35	14.4	1	1	1	2
7x34	Lig	p2y1_off	4.4	0	1	1	1	0
7x35	7x38	Shared	9.35	8.18	1	1	2	2
E2.G193	E2x51	Shared	4.35	2.9	0	0	2	1
E3.Q291	Lig	p2y1_off	3.33	0	0	0	1	0
7x28	NT.L44	p2y1_off	1.36	0	0	0	2	1
E3.Q291	NT.K41	p2y1_on	0	9.49	0	0	1	2
7x28	NT.K46	p2y1_on	0	12.44	0	0	2	1
1x32	2x64	p2y1_on	0	4.13	1	0	2	1
1x32	7x31	p2y1_on	0	13.41	1	0	2	1
1x35	7x35	p2y1_on	0	3.99	0	0	2	2
2x60	3x29	p2y1_on	0	9.72	0	0	2	1
2x63	E2x50	p2y1_on	0	6.72	0	1	1	2
2x63	Lig	p2y1_on	0	8.74	0	1	1	0
2x64	7x38	p2y1_on	0	6.17	0	1	1	2
2x64	Lig	p2y1_on	0	8.01	0	1	1	0
E1.T115	E2.T201	p2y1_on	0	4.71	1	0	2	1
3x29	Lig	p2y1_on	0	4.53	0	1	1	0
E2.K196	E2.R195	p2y1_on	0	17.33	0	0	2	1
E2.R195	E2x51	p2y1_on	0	9.26	1	1	1	1
E2.T201	Lig	p2y1_on	0	3.66	0	1	1	0
E2x51	Lig	p2y1_on	0	10.19	0	1	1	0
E2.T205	E2x52	p2y1_on	0	10.12	1	1	1	1
E2x52	Lig	p2y1_on	0	14.33	0	1	1	0
E2.T205	E2.T206	p2y1_on	0	4.71	1	1	1	2
5x33	E2.T206	p2y1_on	0	4.42	0	0	2	2
6x51	7x34	p2y1_on	0	4.13	7	0	2	1
6x55	7x34	p2y1_on	0	8.36	0	0	2	1
6x58	6x62	p2y1_on	0	9.64	1	0	1	1
6x62	E3.Q291	p2y1_on	0	10.51	1	0	1	1
7x34	7x35	p2y1_on	0	5.64	1	1	1	2
7x34	7x37	p2y1_on	0	3.75	1	1	1	2
1x35	1x36	p2y1_on	0	3.28	0	0	2	2
Lig	NT.T45	p2y1_on	0	2.75	1	1	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	p2y1_off	4XNW-P2Y₁-MRS2500
	p2y1_on	7XXH-P2Y₁-2MeSADP-chim(NtGi1-G11)/β1/γ2

Network Difference
Value	p2y1_off	p2y1_on
I_min	4.35	3.38
Number of Linked Nodes	271	284
Number of Specific Nodes	10 (3.69%)	23 (8.10%)
Number of Shared Nodes	261 (96.31%)	261 (91.90%)
Number of Links	293	321
Number of Specific Links	146 (49.83%)	174 (54.21%)
Number of Shared Links	147 (50.17%)	147 (45.79%)
Number of Hubs	30	44
Number of Specific Hubs	13 (43.33%)	27 (61.36%)
Number of Shared Hubs	17 (56.67%)	17 (38.64%)
Average % Shared Neighbours (Jaccard)	32.54
Average % Shared Neighbours (Otsuka)	41.44
Average % Shared Neighbours (Overlap Coefficient)	49.57
Average % Shared Cliques (k3-6)	51.92
Graphlets Similarity	0.550246

Paths Difference
Value	p2y1_off	p2y1_on
Number Of Nodes in MetaPath	55	64
Specific Nodes in MetaPath	28 (50.91%)	37 (57.81%)
Shared Nodes in MetaPath	261 (96.31%)	261 (96.31%)
Number Of Links MetaPath	56	65
Specific Links in MetaPath	43 (76.79%)	52 (80.00%)
Shared Links in MetaPath	147 (50.17%)	147 (50.17%)
Number of Shortest Paths	60102	57375
Length Of Smallest Path	3	3
Average Path Length	14.6999	13.7738
Length of Longest Path	32	32
Minimum Path Strength	1.555	1.38
Average Path Strength	7.18433	6.65599
Maximum Path Strength	22.09	14.6825
Minimum Path Correlation	0.7	0.7
Average Path Correlation	0.922578	0.930854
Maximum Path Correlation	0.99	0.99
Minimum % Of Corr. Nodes	4.7619	3.84615
Average % Of Corr. Nodes	48.5445	48.9518
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	39.1574	46.8369
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

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