psnGPCR

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Orange: nodes, hubs and links specific of peptide_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of peptide_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	peptide_off Int. Strength	peptide_on Int. Strength	peptide_off Hub1?	peptide_on Hub1?	peptide_off Hub2?	peptide_on Hub2?	ConSurf1	ConSurf2
1	1x50	2x47	peptide_off	100	0	No	No	No	No	9	8
2	1x53	7x53	peptide_off	100	0	No	No	Yes	Yes	9	9
3	2x38	3x49	peptide_off	100	0	Yes	No	Yes	No	6	8
4	2x39	3x50	peptide_off	100	0	No	No	Yes	No	8	9
5	2x48	4x50	peptide_off	100	0	No	No	No	No	6	9
6	2x60	7x38	peptide_off	100	0	No	No	No	No	7	5
7	E1x50	E2	peptide_off	100	0	Yes	Yes	Yes	Yes	8	3
8	3x37	3x41	peptide_off	100	0	Yes	Yes	No	No	6	6
9	3x40	6x44	peptide_off	100	0	No	No	No	No	7	9
10	3x43	6x44	peptide_off	100	0	No	No	No	No	8	9
11	3x44	5x54	peptide_off	100	0	No	No	No	No	7	8
12	3x46	6x37	peptide_off	100	0	No	No	No	No	8	8
13	3x49	3x50	peptide_off	100	0	Yes	No	Yes	No	8	9
14	3x50	6x33	peptide_off	100	0	Yes	No	No	No	9	7
15	3x50	6x34	peptide_off	100	0	Yes	No	No	No	9	6
16	5x39	E2	peptide_off	100	0	Yes	No	Yes	Yes	5	3
17	5x39	5x43	peptide_off	100	0	Yes	No	No	No	5	5
18	5x54	6x41	peptide_off	100	0	No	No	No	No	8	8
19	5x58	6x38	peptide_off	100	0	No	Yes	No	No	8	4
20	6x39	7x56	peptide_off	100	0	No	No	No	No	5	7
21	6x40	7x49	peptide_off	100	0	No	Yes	No	Yes	8	9
22	6x48	6x51	peptide_off	100	0	Yes	Yes	Yes	Yes	8	6
23	6x48	Lig	peptide_off	100	0	Yes	Yes	Yes	Yes	8	0
24	7x53	8x50	peptide_off	100	0	Yes	Yes	No	Yes	9	8
25	1x35	2x64	peptide_off	100	0	No	No	No	No	5	4
26	E1x49	E1x51	peptide_off	100	0	No	No	No	No	4	1
27	3x54	6x30	peptide_off	100	0	No	No	No	Yes	8	6
28	4x61	Lig	peptide_off	100	0	No	No	Yes	Yes	4	0
29	3x30	4x54	peptide_off	100	0	No	No	No	No	5	4
30	2x62	E1x52	peptide_off	60.4167	0	No	No	Yes	Yes	4	7
31	7x54	8x54	peptide_off	42.3611	0	No	Yes	No	No	7	6
32	5x44	5x48	peptide_off	50	0	No	No	No	No	5	4
33	3x54	5x65	peptide_off	45.1389	0	No	No	No	Yes	8	8
34	6x36	7x53	peptide_off	44.4444	0	No	No	Yes	Yes	8	9
35	6x51	7x37	peptide_off	54.8611	0	Yes	Yes	No	No	6	7
36	1x35	1x39	peptide_off	43.75	0	No	No	Yes	No	5	6
37	8x50	8x54	peptide_off	40.2778	0	No	Yes	No	No	8	6
38	7x54	8x51	peptide_off	33.3333	0	No	Yes	No	No	7	8
39	1x42	7x43	peptide_off	38.1944	0	No	No	No	No	7	5
40	5x40	Lig	peptide_off	42.0833	0	No	No	Yes	Yes	4	0
41	5x61	6x34	peptide_off	32.6389	0	No	No	No	No	8	6
42	1x47	2x51	peptide_off	34.4444	0	No	No	No	No	6	8
43	1x56	8x53	peptide_off	50.6944	0	No	No	No	No	8	6
44	3x50	3x53	peptide_off	54.8611	0	Yes	No	No	No	9	8
45	6x32	8x48	peptide_off	33.3333	0	Yes	No	No	No	7	4
46	5x62	5x66	peptide_off	25.6944	0	No	No	No	No	5	4
47	2x52	3x31	peptide_off	36.6667	0	No	No	Yes	No	6	5
48	3x56	I2	peptide_off	25	0	Yes	Yes	No	No	6	0
49	8x49	I1x50	peptide_off	36.8056	0	No	No	No	No	6	7
50	7x31	7x35	peptide_off	34.1667	0	No	No	No	No	4	4
51	1x42	7x39	peptide_off	33.3333	0	No	No	No	No	7	5
52	1x45	7x51	peptide_off	16.6667	0	No	No	No	No	5	7
53	6x58	E3	peptide_off	36.1111	0	No	No	Yes	Yes	5	2
54	2x49	3x38	peptide_off	19.3056	0	No	No	No	No	8	7
55	5x65	6x31	peptide_off	39.3056	0	No	Yes	No	No	8	5
56	7x48	7x52	peptide_off	29.1667	0	No	No	No	No	6	8
57	1x52	8x58	peptide_off	35.8333	0	No	No	No	No	6	5
58	6x27	6x31	peptide_off	42.3611	0	No	No	No	No	3	5
59	5x34	5x35	peptide_off	22.9167	0	No	No	No	No	1	7
60	4x38	4x39	peptide_off	33.3333	0	No	No	No	No	7	2
61	5x41	6x60	peptide_off	25	0	No	No	No	No	5	4
62	1x55	8x57	peptide_off	15.2778	0	No	No	No	No	4	4
63	5x32	E2	peptide_off	25	0	No	No	Yes	Yes	1	3
64	1x36	2x61	peptide_off	23.75	0	No	No	No	No	5	6
65	1x31	7x35	peptide_off	8.33333	0	Yes	Yes	No	No	4	4
66	7x32	7x36	peptide_off	12.5	0	Yes	No	No	No	2	5
67	2x67	NT	peptide_off	16.6667	0	No	No	Yes	Yes	5	2
68	8x51	8x55	peptide_off	21.6667	0	No	No	No	No	8	5
69	4x41	I2x56	peptide_off	15.2778	0	No	No	No	No	5	4
70	5x34	5x38	peptide_off	22.2222	0	No	No	No	No	1	4
71	1x47	2x55	peptide_off	9.72222	0	No	No	No	No	6	4
72	1x58	2x44	peptide_off	35.2778	0	No	No	No	No	3	5
73	7x27	7x30	peptide_off	20.8333	0	No	No	No	No	0	3
74	3x52	I2x53	peptide_off	16.6667	0	No	No	No	No	5	5
75	5x59	5x60	peptide_off	16.6667	0	No	No	No	No	4	4
76	6x28	6x32	peptide_off	28.1944	0	No	No	Yes	No	4	7
77	E1	E2	peptide_off	12.5	0	No	Yes	Yes	Yes	0	3
78	7x26	7x30	peptide_off	22.9167	0	No	No	No	No	0	3
79	1x31	1x34	peptide_off	18.75	0	Yes	Yes	No	No	4	5
80	5x33	5x37	peptide_off	20.1389	0	No	No	No	No	2	3
81	5x64	6x25	peptide_off	8.33333	0	Yes	No	No	No	5	3
82	3x56	I2x51	peptide_off	20.8333	0	Yes	Yes	No	No	6	5
83	5x52	5x56	peptide_off	16.6667	0	No	No	No	No	3	4
84	6x24	6x27	peptide_off	10.4167	0	No	No	No	No	3	3
85	4x41	4x44	peptide_off	16.6667	0	No	No	No	No	5	3
86	2x36	6x32	peptide_off	8.33333	0	No	No	Yes	No	0	7
87	5x69	6x27	peptide_off	20.8333	0	No	No	No	No	0	3
88	7x29	7x32	peptide_off	8.33333	0	No	No	Yes	No	4	2
89	1x60	I1	peptide_off	12.5	0	Yes	Yes	No	No	5	0
90	6x58	6x62	peptide_off	11.1111	0	No	No	No	No	5	0
91	3x56	I2x55	peptide_off	8.33333	0	Yes	Yes	No	No	6	4
92	1x29	1x32	peptide_off	10.4167	0	No	No	No	No	0	4
93	I2x54	I2x57	peptide_off	16.6667	0	No	No	No	Yes	5	6
94	7x28	NT	peptide_off	17.0833	0	No	No	Yes	Yes	0	2
95	8x56	8x63	peptide_off	8.33333	0	No	No	No	No	3	0
96	3x23	3x24	peptide_off	2.77778	0	No	No	No	No	1	5
97	4x55	4x59	peptide_off	4.16667	0	No	No	No	No	4	7
98	6x29	6x33	peptide_off	11.1111	0	No	No	No	No	5	7
99	1x37	1x41	peptide_off	8.33333	0	No	No	No	No	5	5
100	7x25	E3	peptide_off	8.33333	0	No	No	Yes	Yes	0	2
101	5x51	5x55	peptide_off	2.08333	0	No	No	No	No	6	5
102	5x31	5x34	peptide_off	9.72222	0	No	No	No	No	4	1
103	2x35	2x38	peptide_off	8.33333	0	No	No	Yes	No	0	6
104	5x70	5x72	peptide_off	8.33333	0	No	No	No	No	0	0
105	8x58	8x60	peptide_off	8.33333	0	No	No	No	No	5	0
106	2x34	2x38	peptide_off	8.33333	0	No	No	Yes	No	0	6
107	4x47	4x51	peptide_off	2.77778	0	No	No	No	No	4	4
108	6x23	I3	peptide_off	8.33333	0	No	No	No	No	0	4
109	5x69	I3	peptide_off	8.75	0	No	No	No	No	0	4
110	1x27	7x32	peptide_off	8.33333	0	No	No	Yes	No	0	2
111	1x24	7x27	peptide_off	8.33333	0	No	No	No	No	0	0
112	1x23	1x24	peptide_off	8.33333	0	No	No	No	No	0	0
113	8x61	8x62	peptide_off	8.33333	0	No	No	No	No	0	0
114	2x68	E2	peptide_off	2.77778	0	No	No	Yes	Yes	0	3
115	8x59	CT	peptide_off	4.16667	0	No	No	No	No	4	4
116	1x22	1x23	peptide_off	2.77778	0	No	No	No	No	0	0
117	6x63	E3	peptide_off	4.16667	0	No	No	Yes	Yes	0	2
118	2x33	2x36	peptide_off	8.33333	0	No	No	No	No	0	0
119	8x60	CT	peptide_off	4.16667	0	No	No	No	No	0	4
120	8x58	8x61	peptide_off	2.08333	0	No	No	No	No	5	0
121	4x54	4x58	peptide_off	2.08333	0	No	No	No	No	4	4
122	6x20	6x23	peptide_off	4.16667	0	No	No	No	No	0	0
123	5x70	5x71	peptide_off	2.91667	0	No	No	No	No	0	0
124	1x26	1x30	peptide_off	2.77778	0	No	No	No	No	0	4
125	5x28	Lig	peptide_off	0	0	No	No	Yes	Yes	0	0
126	6x22	6x25	peptide_off	2.08333	0	No	No	No	No	0	3
127	8x62	8x64	peptide_off	0	0	No	No	No	No	0	0
128	5x30	5x31	peptide_off	0	0	No	No	No	No	0	4
129	1x22	1x25	peptide_off	0	0	No	No	No	No	0	0
130	6x21	6x25	peptide_off	0	0	No	No	No	No	0	3
131	NT	NT	Shared	100	100	Yes	Yes	Yes	Yes	2	2
132	1x39	2x61	Shared	100	100	Yes	No	No	No	6	6
133	1x42	7x47	Shared	100	38.697	No	No	No	No	7	7
134	1x43	1x47	Shared	100	100	No	No	No	No	7	6
135	1x43	2x57	Shared	100	100	No	No	No	No	7	7
136	1x49	7x50	Shared	100	24.5603	No	No	No	No	7	9
137	1x50	2x50	Shared	100	100	No	No	Yes	Yes	9	9
138	1x50	7x50	Shared	100	100	No	No	No	No	9	9
139	1x55	1x59	Shared	100	50.9091	No	No	No	No	4	5
140	1x57	2x40	Shared	100	39.6174	No	No	Yes	Yes	7	7
141	1x57	2x44	Shared	100	100	No	No	No	No	7	5
142	1x60	I1x50	Shared	100	33.7121	Yes	Yes	No	No	5	7
143	I1x48	I1x51	Shared	100	43.1818	No	No	No	No	6	7
144	2x37	2x40	Shared	100	100	No	No	Yes	Yes	7	7
145	2x42	3x45	Shared	100	100	Yes	Yes	No	No	7	6
146	2x42	3x46	Shared	100	100	Yes	Yes	No	No	7	8
147	2x42	3x49	Shared	100	100	Yes	Yes	Yes	No	7	8
148	2x42	4x45	Shared	100	100	Yes	Yes	No	No	7	6
149	2x42	4x46	Shared	100	100	Yes	Yes	No	No	7	7
150	2x43	7x53	Shared	100	51.4205	No	No	Yes	Yes	8	9
151	2x45	3x42	Shared	100	100	No	No	No	No	9	7
152	2x45	4x46	Shared	100	100	No	No	No	No	9	7
153	2x45	4x50	Shared	100	100	No	No	No	No	9	9
154	2x46	3x42	Shared	100	100	No	Yes	No	No	9	7
155	2x50	3x39	Shared	100	100	Yes	Yes	No	No	9	9
156	2x50	7x46	Shared	100	100	Yes	Yes	No	No	9	8
157	2x50	7x49	Shared	100	100	Yes	Yes	No	Yes	9	9
158	2x53	3x35	Shared	100	100	No	No	No	No	7	8
159	2x57	7x42	Shared	100	100	No	No	No	Yes	7	6
160	2x59	E1x52	Shared	100	100	No	No	Yes	Yes	5	7
161	2x59	3x28	Shared	100	100	No	No	No	No	5	6
162	2x60	7x42	Shared	100	100	No	No	No	Yes	7	6
163	2x60	Lig	Shared	100	100	No	No	Yes	Yes	7	0
164	2x63	E1x50	Shared	100	100	No	No	Yes	Yes	5	8
165	E1x49	E2	Shared	100	100	No	No	Yes	Yes	4	3
166	E1x50	E1x52	Shared	100	100	Yes	Yes	Yes	Yes	8	7
167	3x25	E1x50	Shared	100	100	No	No	Yes	Yes	9	8
168	E1x50	E2x50	Shared	100	100	Yes	Yes	No	No	8	9
169	E1x51	E1x52	Shared	100	100	No	No	Yes	Yes	1	7
170	3x22	3x26	Shared	100	100	No	No	No	No	2	6
171	3x22	E2	Shared	100	100	No	No	Yes	Yes	2	3
172	3x25	E2x50	Shared	100	100	No	No	No	No	9	9
173	3x29	Lig	Shared	100	100	No	No	Yes	Yes	4	0
174	3x32	Lig	Shared	100	100	No	No	Yes	Yes	6	0
175	3x33	Lig	Shared	100	100	No	Yes	Yes	Yes	5	0
176	3x34	4x54	Shared	100	100	No	No	No	No	5	4
177	3x36	6x48	Shared	100	100	No	No	Yes	Yes	7	8
178	3x36	Lig	Shared	100	100	No	No	Yes	Yes	7	0
179	3x37	4x56	Shared	100	100	Yes	Yes	No	No	6	5
180	3x37	5x461	Shared	100	31.1959	Yes	Yes	No	No	6	6
181	3x38	4x50	Shared	100	100	No	No	No	No	7	9
182	3x40	5x50	Shared	100	100	No	No	No	No	7	9
183	3x41	4x49	Shared	100	100	No	No	No	No	6	7
184	3x42	4x49	Shared	100	43.0966	No	No	No	No	7	7
185	3x47	5x54	Shared	100	100	No	No	No	No	9	8
186	3x47	5x58	Shared	100	100	No	No	No	Yes	9	8
187	3x51	5x57	Shared	100	100	Yes	Yes	No	No	7	7
188	3x51	5x60	Shared	100	100	Yes	Yes	No	No	7	4
189	3x54	5x61	Shared	100	100	No	No	No	No	8	8
190	3x55	3x56	Shared	100	100	No	No	Yes	Yes	7	6
191	3x55	5x64	Shared	100	100	No	No	Yes	No	7	5
192	4x64	E2	Shared	100	100	No	No	Yes	Yes	4	3
193	E2	E2	Shared	100	100	Yes	Yes	Yes	Yes	3	3
194	E2	E2x51	Shared	100	100	Yes	Yes	No	No	3	4
195	E2	E2x52	Shared	100	100	Yes	Yes	No	No	3	4
196	5x35	E2	Shared	100	100	No	No	Yes	Yes	7	3
197	5x36	E2	Shared	100	100	No	No	Yes	Yes	4	3
198	5x37	6x60	Shared	100	34.8106	No	No	No	No	3	4
199	5x40	6x59	Shared	100	100	No	No	No	No	4	4
200	5x42	5x46	Shared	100	32.1361	No	No	No	No	3	4
201	5x44	6x52	Shared	100	100	No	No	Yes	Yes	5	8
202	5x44	6x56	Shared	100	100	No	No	No	No	5	5
203	5x47	5x51	Shared	100	100	No	Yes	No	No	8	6
204	5x47	6x49	Shared	100	100	No	Yes	No	No	8	5
205	5x47	6x52	Shared	100	100	No	Yes	Yes	Yes	8	8
206	5x51	6x45	Shared	100	100	No	No	No	No	6	6
207	5x58	6x37	Shared	100	100	No	Yes	No	No	8	8
208	6x26	6x30	Shared	100	26.5152	No	No	No	Yes	4	6
209	6x36	7x56	Shared	100	100	No	No	No	No	8	7
210	6x44	6x48	Shared	100	100	No	No	Yes	Yes	9	8
211	6x47	7x45	Shared	100	100	No	No	No	No	8	9
212	6x48	6x52	Shared	100	100	Yes	Yes	Yes	Yes	8	8
213	6x48	7x41	Shared	100	100	Yes	Yes	No	No	8	7
214	6x48	7x45	Shared	100	100	Yes	Yes	No	No	8	9
215	6x51	6x52	Shared	100	100	Yes	Yes	Yes	Yes	6	8
216	6x51	6x55	Shared	100	100	Yes	Yes	No	No	6	5
217	6x51	Lig	Shared	100	100	Yes	Yes	Yes	Yes	6	0
218	6x54	7x34	Shared	100	100	No	No	No	No	5	4
219	6x55	Lig	Shared	100	100	No	No	Yes	Yes	5	0
220	7x34	Lig	Shared	100	100	No	No	Yes	Yes	4	0
221	7x38	Lig	Shared	100	100	No	No	Yes	Yes	5	0
222	7x45	7x49	Shared	100	100	No	No	No	Yes	9	9
223	8x47	8x50	Shared	100	44.697	No	No	No	Yes	8	8
224	3x51	3x55	Shared	100	100	Yes	Yes	No	No	7	7
225	4x60	5x39	Shared	100	100	No	No	Yes	No	5	5
226	E3	E3	Shared	100	100	Yes	Yes	Yes	Yes	2	2
227	1x39	7x39	Shared	100	100	Yes	No	No	No	6	5
228	6x58	Lig	Shared	100	100	No	No	Yes	Yes	5	0
229	Lig	Lig	Shared	100	100	Yes	Yes	Yes	Yes	0	0
230	4x63	4x64	Shared	100	51.5152	No	No	No	No	4	4
231	E2	NT	Shared	100	100	Yes	Yes	Yes	Yes	3	2
232	3x29	4x65	Shared	100	100	No	No	No	No	4	0
233	3x30	4x62	Shared	100	100	No	No	No	No	5	4
234	3x33	4x57	Shared	100	100	No	Yes	No	No	5	6
235	4x65	E2x52	Shared	100	100	No	No	No	No	0	4
236	6x51	7x41	Shared	100	100	Yes	Yes	No	No	6	7
237	3x33	4x61	Shared	100	100	No	Yes	No	No	5	4
238	2x551	3x31	Shared	100	31.8182	No	No	Yes	No	0	5
239	4x61	5x39	Shared	100	47.3214	No	No	Yes	No	4	5
240	5x66	6x31	Shared	100	22.7273	No	No	No	No	4	5
241	1x52	8x54	Shared	50	100	No	No	No	No	6	6
242	2x38	4x42	Shared	44.5833	100	Yes	No	No	No	6	7
243	3x38	4x53	Shared	50	47.0455	No	No	No	No	7	8
244	1x53	2x47	Shared	44.4444	51.9838	No	No	No	No	9	8
245	3x24	E1x52	Shared	56.9444	100	No	No	Yes	Yes	5	7
246	2x66	E1x51	Shared	52.7778	45.2273	No	No	No	No	4	1
247	6x57	E3	Shared	26.3889	33.6174	No	No	Yes	Yes	4	2
248	1x54	2x44	Shared	49.0278	24.9351	No	No	No	No	7	5
249	5x49	5x50	Shared	41.1111	100	No	No	No	No	5	9
250	2x56	3x32	Shared	44.4444	100	No	No	No	No	7	6
251	3x37	5x46	Shared	16.6667	100	Yes	Yes	No	No	6	4
252	1x59	1x60	Shared	27.0833	31.0606	No	No	Yes	Yes	5	5
253	1x35	7x35	Shared	55.9722	100	No	No	No	No	5	4
254	1x39	2x57	Shared	48.6111	100	Yes	No	No	No	6	7
255	2x46	3x43	Shared	52.7778	100	No	Yes	No	No	9	8
256	4x59	4x60	Shared	46.8056	100	No	No	No	No	7	5
257	2x53	7x42	Shared	33.0556	100	No	No	No	Yes	7	6
258	1x54	2x48	Shared	56.25	24.868	No	No	No	No	7	6
259	3x27	3x31	Shared	28.8889	31.5814	No	No	Yes	No	5	5
260	1x45	7x47	Shared	40.8333	35.8501	No	No	No	No	5	7
261	6x50	7x40	Shared	39.4444	59.9932	No	No	No	No	9	8
262	1x43	2x58	Shared	37.6389	100	No	No	No	No	7	8
263	1x46	2x54	Shared	40.2778	34.6875	No	No	No	No	8	6
264	6x49	6x50	Shared	28.3333	100	No	No	No	No	5	9
265	6x61	E3	Shared	35.1389	100	No	No	Yes	Yes	2	2
266	3x51	5x61	Shared	33.3333	33.9773	Yes	Yes	No	No	7	8
267	3x34	4x57	Shared	31.25	100	No	No	No	No	5	6
268	6x40	7x52	Shared	50	100	No	Yes	No	No	8	8
269	6x54	7x33	Shared	38.1944	47.7273	No	No	No	No	5	4
270	2x54	7x46	Shared	46.9444	28.0114	No	No	No	No	6	8
271	1x38	7x39	Shared	23.6111	51.2879	No	No	No	No	5	5
272	6x56	6x60	Shared	41.6667	31.8182	No	No	No	No	5	4
273	2x40	I1x50	Shared	50.6944	43.0871	Yes	Yes	No	No	7	7
274	3x48	5x57	Shared	32.6389	25.7035	No	No	No	No	6	7
275	3x44	5x53	Shared	27.0833	100	No	No	No	No	7	6
276	3x49	I2x57	Shared	25	100	Yes	No	No	Yes	8	6
277	5x56	5x60	Shared	25	32.1023	No	No	No	No	4	4
278	7x30	E3	Shared	35.4167	43.9394	No	No	Yes	Yes	3	2
279	3x52	I2	Shared	25	9.09091	No	No	No	No	5	0
280	8x48	8x51	Shared	43.75	100	No	No	No	No	4	8
281	2x41	4x39	Shared	29.0278	32.6948	Yes	Yes	No	No	5	2
282	6x43	7x52	Shared	30.5556	34.0368	No	No	No	No	7	8
283	1x36	2x65	Shared	48.0556	100	No	No	No	No	5	4
284	4x38	4x41	Shared	36.1111	43.0736	No	No	No	No	7	5
285	1x51	2x51	Shared	38.1944	19.2708	No	No	No	No	4	8
286	1x28	1x31	Shared	27.0833	27.2727	No	No	Yes	Yes	0	4
287	2x41	4x42	Shared	27.7778	44.1572	Yes	Yes	No	No	5	7
288	1x60	8x53	Shared	25.6944	44.697	Yes	Yes	No	No	5	6
289	1x48	1x49	Shared	9.02778	29.4508	No	No	No	No	4	7
290	6x49	6x53	Shared	29.5833	37.0265	No	No	No	No	5	5
291	1x32	2x65	Shared	20.6944	18.1818	No	No	No	No	4	4
292	4x38	4x40	Shared	24.1667	27.4242	No	No	No	No	7	4
293	2x56	3x31	Shared	22.2222	30.2083	No	No	Yes	No	7	5
294	6x42	6x46	Shared	21.6667	4.16667	No	No	No	No	5	6
295	2x41	I1x51	Shared	20.8333	19.3182	Yes	Yes	No	No	5	7
296	1x31	7x32	Shared	34.0278	23.1534	Yes	Yes	Yes	No	4	2
297	5x64	5x68	Shared	31.25	27.2727	Yes	No	No	No	5	6
298	7x51	7x55	Shared	13.3333	37.9091	No	No	No	No	7	6
299	5x45	5x48	Shared	23.1944	28.6269	No	No	No	No	5	4
300	3x21	E1x50	Shared	0	11.1364	No	No	Yes	Yes	7	8
301	3x41	4x52	Shared	12.9167	25.8807	No	No	No	No	6	4
302	6x32	6x35	Shared	29.1667	21.641	Yes	No	No	No	7	6
303	1x60	I1x49	Shared	20.1389	38.6364	Yes	Yes	No	No	5	5
304	3x56	I2x52	Shared	20.6944	45.6534	Yes	Yes	No	No	6	4
305	2x41	4x43	Shared	15.9722	100	Yes	Yes	No	No	5	4
306	1x40	2x61	Shared	20.8333	16.4773	No	No	No	No	4	6
307	5x59	5x63	Shared	20.8333	13.6364	No	No	No	No	4	4
308	4x48	4x52	Shared	12.5	9.54545	No	No	No	No	4	4
309	1x60	8x56	Shared	24.3056	21.158	Yes	Yes	No	No	5	3
310	1x44	1x48	Shared	16.6667	9.84848	No	No	No	No	5	4
311	1x30	1x31	Shared	20.8333	26.5152	No	No	Yes	Yes	4	4
312	3x56	I2x50	Shared	8.33333	9.41558	Yes	Yes	No	No	6	8
313	6x38	6x42	Shared	2.5	15.1515	No	No	No	No	4	5
314	5x64	5x67	Shared	20.8333	23.8352	Yes	No	No	No	5	4
315	8x48	8x52	Shared	10.4167	15.7148	No	No	No	No	4	5
316	7x23	7x26	Shared	12.5	9.09091	No	No	No	No	0	0
317	5x29	E3	Shared	8.33333	9.09091	No	No	Yes	Yes	0	2
318	1x29	1x33	Shared	8.33333	18.4659	No	No	No	Yes	0	5
319	4x51	4x55	Shared	4.16667	2.27273	No	No	No	No	4	4
320	7x24	NT	Shared	16.6667	11.3636	No	No	Yes	Yes	0	2
321	1x41	1x45	Shared	2.77778	11.553	No	No	No	No	5	5
322	2x40	I1x52	Shared	8.33333	9.09091	Yes	Yes	No	No	7	0
323	5x66	5x70	Shared	0	17.4242	No	No	No	No	4	0
324	6x64	E3	Shared	0	3.78788	No	No	Yes	Yes	0	2
325	1x50	2x51	peptide_on	0	100	No	No	No	No	9	8
326	1x53	7x54	peptide_on	0	100	No	No	No	Yes	9	7
327	1x56	8x50	peptide_on	0	100	No	No	No	Yes	8	8
328	2x46	2x50	peptide_on	0	100	No	Yes	Yes	Yes	9	9
329	2x52	3x35	peptide_on	0	100	No	No	No	No	6	8
330	2x53	7x46	peptide_on	0	100	No	No	No	No	7	8
331	2x64	7x35	peptide_on	0	100	No	No	No	No	4	4
332	3x40	6x48	peptide_on	0	100	No	No	Yes	Yes	7	8
333	3x43	7x53	peptide_on	0	100	No	No	Yes	Yes	8	9
334	3x46	7x53	peptide_on	0	100	No	No	Yes	Yes	8	9
335	3x50	5x58	peptide_on	0	100	Yes	No	No	Yes	9	8
336	3x50	7x53	peptide_on	0	100	Yes	No	Yes	Yes	9	9
337	E2	Lig	peptide_on	0	100	Yes	Yes	Yes	Yes	3	0
338	5x43	Lig	peptide_on	0	100	No	No	Yes	Yes	5	0
339	5x51	6x44	peptide_on	0	100	No	No	No	No	6	9
340	5x54	5x58	peptide_on	0	100	No	No	No	Yes	8	8
341	5x58	6x41	peptide_on	0	100	No	Yes	No	No	8	8
342	5x62	6x34	peptide_on	0	100	No	No	No	No	5	6
343	5x65	6x30	peptide_on	0	100	No	Yes	No	Yes	8	6
344	6x40	7x53	peptide_on	0	100	No	Yes	Yes	Yes	8	9
345	7x31	Lig	peptide_on	0	100	No	No	Yes	Yes	4	0
346	7x34	7x38	peptide_on	0	100	No	No	No	No	4	5
347	7x38	7x42	peptide_on	0	100	No	No	No	Yes	5	6
348	7x49	7x53	peptide_on	0	100	No	Yes	Yes	Yes	9	9
349	7x54	8x50	peptide_on	0	100	No	Yes	No	Yes	7	8
350	2x46	7x49	peptide_on	0	100	No	Yes	No	Yes	9	9
351	3x43	7x49	peptide_on	0	100	No	No	No	Yes	8	9
352	3x46	3x50	peptide_on	0	100	No	No	Yes	No	8	9
353	5x58	6x40	peptide_on	0	100	No	Yes	No	Yes	8	8
354	6x54	7x37	peptide_on	0	100	No	No	No	No	5	7
355	E2x51	Lig	peptide_on	0	100	No	No	Yes	Yes	4	0
356	2x63	Lig	peptide_on	0	100	No	No	Yes	Yes	5	0
357	E3	Lig	peptide_on	0	100	Yes	Yes	Yes	Yes	2	0
358	7x27	Lig	peptide_on	0	100	No	No	Yes	Yes	0	0
359	Lig	NT	peptide_on	0	100	Yes	Yes	Yes	Yes	0	2
360	2x64	Lig	peptide_on	0	100	No	No	Yes	Yes	4	0
361	E2x52	Lig	peptide_on	0	100	No	No	Yes	Yes	4	0
362	E1	Lig	peptide_on	0	100	No	Yes	Yes	Yes	0	0
363	2x43	7x54	peptide_on	0	39.2045	No	No	No	Yes	8	7
364	3x33	3x37	peptide_on	0	45.8333	No	Yes	Yes	Yes	5	6
365	3x47	5x57	peptide_on	0	60.9307	No	No	No	No	9	7
366	2x42	4x42	peptide_on	0	48.0606	Yes	Yes	No	No	7	7
367	3x44	5x50	peptide_on	0	52.2727	No	No	No	No	7	9
368	8x47	8x49	peptide_on	0	34.8485	No	No	No	No	8	6
369	6x43	7x48	peptide_on	0	43.6648	No	No	No	No	7	6
370	3x30	4x57	peptide_on	0	38.5606	No	No	No	No	5	6
371	5x65	6x33	peptide_on	0	37.5	No	Yes	No	No	8	7
372	1x46	7x47	peptide_on	0	34.9107	No	No	No	No	8	7
373	2x49	3x39	peptide_on	0	37.197	No	No	No	No	8	9
374	I2x52	I2x56	peptide_on	0	24.9811	No	No	No	No	4	4
375	5x47	5x48	peptide_on	0	33.5444	No	Yes	No	No	8	4
376	5x36	6x59	peptide_on	0	30.6818	No	No	No	No	4	4
377	4x41	4x45	peptide_on	0	32.9004	No	No	No	No	5	6
378	2x37	2x39	peptide_on	0	38.7771	No	No	No	No	7	8
379	5x32	5x35	peptide_on	0	24.6212	No	No	No	No	1	7
380	2x62	2x66	peptide_on	0	26.714	No	No	No	No	4	4
381	8x54	8x58	peptide_on	0	32.7273	No	No	No	No	6	5
382	7x43	7x48	peptide_on	0	26.2311	No	No	No	No	5	6
383	1x60	8x57	peptide_on	0	32.197	Yes	Yes	No	No	5	4
384	7x55	8x50	peptide_on	0	43.4659	No	No	No	Yes	6	8
385	5x62	6x37	peptide_on	0	27.5027	No	No	No	No	5	8
386	7x26	E3	peptide_on	0	25	No	No	Yes	Yes	0	2
387	2x67	Lig	peptide_on	0	23.0133	No	No	Yes	Yes	5	0
388	1x54	2x47	peptide_on	0	23.6607	No	No	No	No	7	8
389	5x66	6x34	peptide_on	0	25	No	No	No	No	4	6
390	2x51	2x55	peptide_on	0	35.2273	No	No	No	No	8	4
391	3x53	I2x57	peptide_on	0	35.9848	No	No	No	Yes	8	6
392	5x61	5x65	peptide_on	0	9.89583	No	No	No	Yes	8	8
393	3x52	3x56	peptide_on	0	26.4773	No	No	Yes	Yes	5	6
394	5x55	6x41	peptide_on	0	21.3068	No	No	No	No	5	8
395	I2x53	I2x57	peptide_on	0	25.2841	No	No	No	Yes	5	6
396	7x28	7x32	peptide_on	0	17.1212	No	No	Yes	No	0	2
397	1x56	8x54	peptide_on	0	23.911	No	No	No	No	8	6
398	1x32	2x67	peptide_on	0	13.961	No	No	No	No	4	5
399	5x34	E2	peptide_on	0	21.2121	No	No	Yes	Yes	1	3
400	7x36	7x40	peptide_on	0	22.9261	No	No	No	No	5	8
401	6x39	7x52	peptide_on	0	13.5152	No	No	No	No	5	8
402	1x31	1x35	peptide_on	0	20.4545	Yes	Yes	No	No	4	5
403	5x63	5x67	peptide_on	0	25	No	No	No	No	4	4
404	4x40	4x44	peptide_on	0	17.1115	No	No	No	No	4	3
405	5x31	E2	peptide_on	0	22.7273	No	No	Yes	Yes	4	3
406	6x32	6x36	peptide_on	0	20.1326	Yes	No	No	No	7	8
407	6x36	6x40	peptide_on	0	10.6061	No	No	No	Yes	8	8
408	5x38	5x42	peptide_on	0	17.803	No	No	No	No	4	3
409	1x58	1x59	peptide_on	0	12.1144	No	No	No	No	3	5
410	7x29	7x33	peptide_on	0	20.6656	No	No	No	No	4	4
411	I2x50	I2x51	peptide_on	0	10.9848	No	No	No	No	8	5
412	5x33	5x34	peptide_on	0	14.7727	No	No	No	No	2	1
413	I2x55	I2x56	peptide_on	0	19.1212	No	No	No	No	4	4
414	5x62	6x38	peptide_on	0	18.1818	No	No	No	No	5	4
415	5x65	I3	peptide_on	0	13.6364	No	Yes	No	No	8	4
416	6x23	6x26	peptide_on	0	14.3939	No	No	No	No	0	4
417	2x40	I1	peptide_on	0	9.09091	Yes	Yes	No	No	7	0
418	8x52	8x53	peptide_on	0	11.3636	No	No	No	No	5	6
419	6x27	6x30	peptide_on	0	16.2879	No	No	No	Yes	3	6
420	6x28	6x31	peptide_on	0	13.3049	No	No	No	No	4	5
421	6x62	E2	peptide_on	0	4.54545	No	No	Yes	Yes	0	3
422	1x32	1x33	peptide_on	0	11.7424	No	No	No	Yes	4	5
423	5x69	6x30	peptide_on	0	10	No	No	No	Yes	0	6
424	6x29	6x32	peptide_on	0	14.3939	No	No	Yes	No	5	7
425	5x40	5x41	peptide_on	0	11.3636	No	No	No	No	4	5
426	6x25	6x28	peptide_on	0	14.3939	No	No	No	No	3	4
427	1x23	E2	peptide_on	0	4.54545	No	No	Yes	Yes	0	3
428	7x25	7x26	peptide_on	0	11.3636	No	No	No	No	0	0
429	5x48	5x52	peptide_on	0	11.7424	No	No	No	No	4	3
430	8x52	8x55	peptide_on	0	8.38068	No	No	No	No	5	5
431	8x55	8x59	peptide_on	0	7.57576	No	No	No	No	5	4
432	1x33	1x37	peptide_on	0	11.9318	No	Yes	No	No	5	5
433	1x33	1x34	peptide_on	0	9.09091	No	Yes	No	No	5	5
434	3x23	3x26	peptide_on	0	15.6439	No	No	No	No	1	6
435	I2x53	I2x54	peptide_on	0	4.54545	No	No	No	No	5	5
436	6x24	I3	peptide_on	0	7.72727	No	No	No	No	3	4
437	1x21	E2	peptide_on	0	4.54545	No	No	Yes	Yes	0	3
438	5x28	E2	peptide_on	0	9.09091	No	No	Yes	Yes	0	3
439	2x34	2x36	peptide_on	0	4.54545	No	No	No	No	0	0
440	2x36	2x40	peptide_on	0	4.54545	No	No	Yes	Yes	0	7
441	6x22	I3	peptide_on	0	5.68182	No	No	No	No	0	4
442	5x24	5x27	peptide_on	0	4.54545	No	No	No	No	0	0
443	4x55	4x56	peptide_on	0	3.50379	No	No	No	No	4	5
444	1x60	CT	peptide_on	0	4.54545	Yes	Yes	No	No	5	4
445	4x43	4x47	peptide_on	0	2.55682	No	No	No	No	4	4
446	5x72	6x30	peptide_on	0	7.95455	No	No	No	Yes	0	6
447	1x61	8x53	peptide_on	0	4.54545	No	No	No	No	0	6
448	2x68	Lig	peptide_on	0	4.54545	No	No	Yes	Yes	0	0
449	1x22	7x23	peptide_on	0	4.54545	No	No	No	No	0	0
450	5x68	5x71	peptide_on	0	1.81818	No	No	No	No	6	0
451	1x26	1x31	peptide_on	0	4.54545	No	No	Yes	Yes	0	4
452	6x59	6x63	peptide_on	0	3.78788	No	No	No	No	4	0
453	5x30	5x35	peptide_on	0	4.54545	No	No	No	No	0	7
454	1x24	Lig	peptide_on	0	4.54545	No	No	Yes	Yes	0	0
455	7x54	7x60	peptide_on	0	4.54545	No	Yes	No	No	7	0
456	2x35	I2x57	peptide_on	0	4.54545	No	No	No	Yes	0	6
457	5x27	E2	peptide_on	0	4.54545	No	No	Yes	Yes	0	3
458	7x61	CT	peptide_on	0	4.54545	No	No	No	No	0	4
459	1x24	1x25	peptide_on	0	4.54545	No	No	No	No	0	0
460	3x17	3x18	peptide_on	0	4.54545	No	No	No	No	0	0
461	3x30	4x58	peptide_on	0	0.818182	No	No	No	No	5	4
462	3x20	E1	peptide_on	0	4.54545	No	No	No	Yes	0	0
463	3x16	E1x49	peptide_on	0	4.54545	No	No	No	No	0	4
464	8x60	8x61	peptide_on	0	3.18182	No	No	No	No	0	0
465	1x60	8x60	peptide_on	0	4.54545	Yes	Yes	No	No	5	0
466	5x69	5x73	peptide_on	0	1.13636	No	No	No	No	0	0
467	1x27	1x30	peptide_on	0	0	No	No	No	No	0	4
468	3x19	3x23	peptide_on	0	0.909091	No	No	No	No	0	1
469	5x25	5x26	peptide_on	0	2.27273	No	No	No	No	0	0
470	5x72	5x75	peptide_on	0	0	No	No	No	No	0	0
471	5x25	5x28	peptide_on	0	2.27273	No	No	No	No	0	0
472	1x64	I1	peptide_on	0	2.27273	No	No	No	No	0	0
473	3x16	3x17	peptide_on	0	2.27273	No	No	No	No	0	0
474	4x37	4x40	peptide_on	0	0	No	No	No	No	0	4
475	1x20	1x22	peptide_on	0	0	No	No	No	No	0	0
476	5x74	5x75	peptide_on	0	0	No	No	No	No	0	0
477	1x62	1x63	peptide_on	0	0	No	No	No	No	0	0
478	1x63	1x64	peptide_on	0	0	No	No	No	No	0	0
479	7x57	CT	peptide_on	0	0	No	No	No	No	0	4
480	5x72	5x76	peptide_on	0	0.30303	No	No	No	No	0	0
481	7x58	7x59	peptide_on	0	0	No	No	No	No	0	0
482	7x59	7x61	peptide_on	0	0	No	No	No	No	0	0
483	2x70	E1	peptide_on	0	0	No	No	No	Yes	0	0
484	2x69	E1	peptide_on	0	0	No	No	No	Yes	0	0
485	5x73	5x77	peptide_on	0	0	No	No	No	No	0	0

Orange: nodes, hubs and links specific of peptide_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of peptide_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	peptide_off Avg Int. Strength	peptide_on Avg Int. Strength	peptide_off Num Of Links	peptide_on Num Of Links	ConSurf
1	1x39	peptide_off	37.5	30.5758	4	3	6
2	2x38	peptide_off	16.6667	0	4	1	6
3	3x31	peptide_off	0	2.27273	4	3	5
4	3x49	peptide_off	8.33333	1.51515	4	2	8
5	3x50	peptide_off	43.0556	4.54545	5	3	9
6	5x39	peptide_off	26.3889	15.5303	4	2	5
7	5x64	peptide_off	0	0	4	3	5
8	6x32	peptide_off	4.16667	0	4	3	7
9	7x32	peptide_off	0	0	4	2	2
10	NT	Shared	16.6667	24.8106	6	5	2
11	1x31	Shared	2.77778	4.54545	5	5	4
12	1x60	Shared	4.16667	12.1212	6	8	5
13	2x40	Shared	8.33333	10.8788	4	6	7
14	2x41	Shared	0	0	4	4	5
15	2x42	Shared	71.3889	50.9943	5	6	7
16	2x50	Shared	30.5556	67.6082	4	5	9
17	E1x50	Shared	90.2778	69.4129	6	5	8
18	E1x52	Shared	34.7222	29.4169	5	4	7
19	3x37	Shared	27.0833	31.9805	4	4	6
20	3x51	Shared	34.0278	51.7045	4	4	7
21	3x56	Shared	4.16667	0	6	4	6
22	E2	Shared	100	95.4545	15	18	3
23	6x48	Shared	92.6389	87.5189	7	6	8
24	6x51	Shared	38.8889	45.6136	6	4	6
25	6x52	Shared	33.3333	32.8409	4	4	8
26	E3	Shared	41.6667	66.2879	10	9	2
27	7x53	Shared	39.7222	68.9394	4	6	9
28	Lig	Shared	100	98.4848	16	26	0
29	1x33	peptide_on	0	0	1	4	5
30	2x46	peptide_on	2.77778	16.2121	2	4	9
31	3x33	peptide_on	22.2222	16.5043	3	4	5
32	I2x57	peptide_on	0	12.5	2	4	6
33	5x47	peptide_on	44.7222	21.5162	3	4	8
34	5x58	peptide_on	25	79.7321	3	6	8
35	5x65	peptide_on	0	0	2	4	8
36	6x30	peptide_on	0	2.27273	2	5	6
37	6x40	peptide_on	8.33333	2.27273	2	4	8
38	7x42	peptide_on	57.6389	46.2662	3	4	6
39	7x49	peptide_on	8.33333	20.0152	3	5	9
40	7x54	peptide_on	0	0	2	4	7
41	8x50	peptide_on	42.3611	30.7359	3	4	8
42	E1	peptide_on	0	7.27273	1	4	0

Orange: nodes, hubs and links specific of peptide_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of peptide_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	peptide_off Recurrence	peptide_on Recurrence	peptide_off Hub1?	peptide_on Hub1?	peptide_off Hub2?	peptide_on Hub2?	ConSurf1	ConSurf2
1	1x39	2x57	peptide_off	42.4376	8.36394	Yes	No	No	No	6	7
2	4x61	Lig	peptide_off	47.434	0	No	No	Yes	Yes	4	0
3	4x61	5x39	peptide_off	47.8168	3.57917	No	No	Yes	No	4	5
4	5x39	E2	peptide_off	39.5202	0	Yes	No	Yes	Yes	5	3
5	1x39	2x61	peptide_off	10.4289	3.36253	Yes	No	No	No	6	6
6	1x42	7x39	peptide_off	12.44	0	No	No	No	No	7	5
7	1x39	7x39	peptide_off	15.4543	3.36253	Yes	No	No	No	6	5
8	6x48	Lig	peptide_off	97.8338	0	Yes	Yes	Yes	Yes	8	0
9	1x50	2x47	peptide_off	32.3722	0	No	No	No	No	9	8
10	1x54	2x48	peptide_off	23.3487	1.27155	No	No	No	No	7	6
11	2x48	4x50	peptide_off	24.6717	0	No	No	No	No	6	9
12	2x45	4x50	peptide_off	29.8667	4.35779	No	No	No	No	9	9
13	2x45	3x42	peptide_off	93.0216	5.07676	No	No	No	No	9	7
14	2x46	3x43	peptide_off	98.0858	4.22279	No	Yes	No	No	9	8
15	3x43	6x44	peptide_off	98.488	0	No	No	No	No	8	9
16	6x44	6x48	peptide_off	100	3.66394	No	No	Yes	Yes	9	8
17	2x41	4x42	peptide_off	13.6806	5.54457	Yes	Yes	No	No	5	7
18	2x38	4x42	peptide_off	15.1006	1.06433	Yes	No	No	No	6	7
19	2x38	3x49	peptide_off	18.2263	0	Yes	No	Yes	No	6	8
20	2x42	3x49	peptide_off	66.8379	5.10816	Yes	Yes	Yes	No	7	8
21	2x42	4x46	peptide_off	77.921	3.10508	Yes	Yes	No	No	7	7
22	2x45	4x46	peptide_off	78.6819	2.81624	No	No	No	No	9	7
23	3x49	3x50	peptide_off	52.1056	0	Yes	No	Yes	No	8	9
24	1x53	7x53	peptide_off	29.828	0	No	No	Yes	Yes	9	9
25	E1x50	E2	peptide_off	14.8437	0	Yes	Yes	Yes	Yes	8	3
26	3x41	4x49	peptide_off	11.781	5.32793	No	No	No	No	6	7
27	3x42	4x49	peptide_off	13.2106	7.0924	No	No	No	No	7	7
28	3x46	6x37	peptide_off	13.8115	0	No	No	No	No	8	8
29	5x61	6x34	peptide_off	46.2321	0	No	No	No	No	8	6
30	3x50	6x34	peptide_off	46.9881	0	Yes	No	No	No	9	6
31	3x54	5x61	peptide_off	19.3555	1.81784	No	No	No	No	8	8
32	5x44	6x52	peptide_off	15.3962	5.00769	No	No	Yes	Yes	5	8
33	6x51	6x52	peptide_off	10.1817	8.95733	Yes	Yes	Yes	Yes	6	8
34	6x51	Lig	peptide_off	11.432	8.12533	Yes	Yes	Yes	Yes	6	0
35	7x53	8x50	peptide_off	24.0126	0	Yes	Yes	No	Yes	9	8
36	1x35	1x39	peptide_off	18.0276	0	No	No	Yes	No	5	6
37	5x65	6x31	peptide_off	13.8163	0	No	Yes	No	No	8	5
38	3x54	5x65	peptide_off	15.2314	0	No	No	No	Yes	8	8
39	8x50	8x54	peptide_off	21.7688	0	No	Yes	No	No	8	6
40	6x58	E3	peptide_off	16.8694	0	No	No	Yes	Yes	5	2
41	6x58	Lig	peptide_off	18.9872	0.860256	No	No	Yes	Yes	5	0
42	7x54	8x54	peptide_off	12.7211	0	No	Yes	No	No	7	6
43	7x54	8x51	peptide_off	11.3448	0	No	Yes	No	No	7	8
44	1x35	7x35	peptide_off	15.0472	8.81605	No	No	No	No	5	4
45	1x31	7x35	peptide_off	12.5127	0	Yes	Yes	No	No	4	4
46	2x57	7x42	Shared	51.2576	14.9446	No	No	No	Yes	7	6
47	2x60	7x42	Shared	54.6693	12.728	No	No	No	Yes	7	6
48	2x60	Lig	Shared	55.1781	12.8536	No	No	Yes	Yes	7	0
49	1x50	2x50	Shared	38.4541	15.4187	No	No	Yes	Yes	9	9
50	2x50	7x49	Shared	44.2937	25.8422	Yes	Yes	No	Yes	9	9
51	7x45	7x49	Shared	49.891	87.4415	No	No	No	Yes	9	9
52	6x48	7x45	Shared	52.062	87.0145	Yes	Yes	No	No	8	9
53	1x53	2x47	Shared	31.1267	34.3349	No	No	No	No	9	8
54	1x60	I1x50	Shared	12.2559	19.7231	Yes	Yes	No	No	5	7
55	2x40	I1x50	Shared	14.2137	20.4735	Yes	Yes	No	No	7	7
56	1x57	2x40	Shared	17.9598	29.0289	No	No	Yes	Yes	7	7
57	1x57	2x44	Shared	19.3167	30.1027	No	No	No	No	7	5
58	1x54	2x44	Shared	22.016	31.1701	No	No	No	No	7	5
59	2x46	3x42	Shared	97.6739	13.0514	No	Yes	No	No	9	7
60	2x42	3x46	Shared	15.1829	20.9727	Yes	Yes	No	No	7	8
61	5x58	6x37	Shared	12.7986	18.0968	No	Yes	No	No	8	8
62	3x51	5x61	Shared	28.5874	22.6963	Yes	Yes	No	No	7	8
63	3x51	3x55	Shared	17.9646	23.9208	Yes	Yes	No	No	7	7
64	6x48	6x52	Shared	23.1354	11.8175	Yes	Yes	Yes	Yes	8	8
65	5x47	6x52	Shared	16.5883	12.0122	No	Yes	Yes	Yes	8	8
66	7x38	Lig	peptide_on	1.15338	13.2994	No	No	Yes	Yes	5	0
67	7x38	7x42	peptide_on	0	13.852	No	No	No	Yes	5	6
68	2x53	7x42	peptide_on	3.16453	24.7057	No	No	No	Yes	7	6
69	2x53	7x46	peptide_on	0	24.084	No	No	No	No	7	8
70	2x50	7x46	peptide_on	4.48752	23.9082	Yes	Yes	No	No	9	8
71	3x36	Lig	peptide_on	0.382845	70.7293	No	No	Yes	Yes	7	0
72	3x36	6x48	peptide_on	0.891689	71.2254	No	No	Yes	Yes	7	8
73	7x49	7x53	peptide_on	0	100	No	Yes	Yes	Yes	9	9
74	2x43	7x53	peptide_on	1.42476	45.5653	No	No	Yes	Yes	8	9
75	2x43	7x54	peptide_on	0	44.9719	No	No	No	Yes	8	7
76	1x53	7x54	peptide_on	0	35.3772	No	No	No	Yes	9	7
77	1x54	2x47	peptide_on	0	33.2862	No	No	No	No	7	8
78	3x46	7x53	peptide_on	0	17.2805	No	No	Yes	Yes	8	9
79	2x63	Lig	peptide_on	0	15.3904	No	No	Yes	Yes	5	0
80	2x63	E1x50	peptide_on	1.58469	14.571	No	No	Yes	Yes	5	8
81	2x64	Lig	peptide_on	0	10.4863	No	No	Yes	Yes	4	0
82	E2	Lig	peptide_on	0	28.2503	Yes	Yes	Yes	Yes	3	0
83	3x33	Lig	peptide_on	9.11558	22.621	No	Yes	Yes	Yes	5	0
84	3x33	3x37	peptide_on	0	10.1943	No	Yes	Yes	Yes	5	6
85	3x50	7x53	peptide_on	0	35.6567	Yes	No	Yes	Yes	9	9
86	3x50	5x58	peptide_on	0	39.5121	Yes	No	No	Yes	9	8
87	3x47	5x58	peptide_on	7.43397	55.0501	No	No	No	Yes	9	8
88	6x40	7x53	peptide_on	0	44.8495	No	Yes	Yes	Yes	8	9
89	5x58	6x40	peptide_on	0	36.9188	No	Yes	No	Yes	8	8
90	3x47	5x57	peptide_on	0	53.5431	No	No	No	No	9	7
91	3x51	5x57	peptide_on	2.99976	50.2653	Yes	Yes	No	No	7	7
92	3x55	3x56	peptide_on	9.43058	13.3528	No	No	Yes	Yes	7	6
93	5x62	6x37	peptide_on	0	16.2852	No	No	No	No	5	8
94	5x61	5x65	peptide_on	0	19.1203	No	No	No	Yes	8	8
95	5x65	6x30	peptide_on	0	12.7123	No	Yes	No	Yes	8	6

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
NT	NT	Shared	7.90005	3.31789	1	1	1	1
2x60	7x38	peptide_off	3.93129	0	1	1	1	1
2x60	7x42	Shared	4.46999	3.4283	1	1	1	2
2x60	Lig	Shared	6.0746	7.38677	1	1	1	0
2x63	E1x50	Shared	6.34799	5.04688	0	1	1	2
E1x49	E2	Shared	7.39349	5.76275	1	1	2	1
E1x50	E2	peptide_off	4.04825	0	1	1	2	1
3x22	E2	Shared	9.03167	5.89084	1	1	2	1
3x29	Lig	Shared	6.40883	5.1679	1	1	1	0
3x32	Lig	Shared	12.6799	6.47997	1	1	1	0
3x33	Lig	Shared	4.45817	5.69767	1	1	1	0
3x36	6x48	Shared	7.16465	4.3527	1	1	1	1
3x36	Lig	Shared	4.81317	3.71296	1	1	1	0
3x40	6x44	peptide_off	6.15082	0	0	0	2	2
4x64	E2	Shared	10.7247	7.78506	1	1	2	1
E2	E2	Shared	56.2461	48.191	1	1	1	1
E2	E2x51	Shared	9.37297	8.71088	1	1	1	1
E2	E2x52	Shared	5.58213	4.11871	1	1	1	1
5x35	E2	Shared	10.0591	3.72961	1	1	2	1
5x36	E2	Shared	8.07915	7.38923	0	1	2	1
5x39	E2	peptide_off	4.08022	0	1	0	2	1
5x39	5x43	peptide_off	4.65131	0	1	0	2	1
5x40	6x59	Shared	5.73174	5.45094	1	0	1	2
6x44	6x48	Shared	12.601	7.8151	0	0	2	1
6x48	6x51	peptide_off	3.74607	0	1	0	1	1
6x48	6x52	Shared	4.83183	3.44841	1	0	1	2
6x48	7x41	Shared	8.86901	4.95062	1	0	1	2
6x48	7x45	Shared	6.04474	8.26731	1	0	1	2
6x48	Lig	peptide_off	4.77504	0	1	0	1	0
6x51	6x52	Shared	4.67507	3.80682	1	1	1	2
6x51	6x55	Shared	6.56279	6.35007	1	1	1	1
6x51	Lig	Shared	6.53014	6.43991	1	1	1	0
6x54	7x34	Shared	6.3875	5.55826	0	0	2	1
6x55	Lig	Shared	12.0844	7.92579	1	1	1	0
7x34	Lig	Shared	5.73965	11.0868	1	1	1	0
7x38	Lig	Shared	5.12715	5.83828	1	1	1	0
1x35	2x64	peptide_off	4.16811	0	0	0	2	1
E3	E3	Shared	9.17367	8.69097	1	1	1	1
6x58	Lig	Shared	5.42472	8.79613	1	0	1	0
E2	NT	Shared	4.70524	5.74549	1	1	1	1
3x29	4x65	Shared	8.36761	7.13288	1	1	1	2
3x33	4x57	Shared	3.69404	3.27046	1	1	1	2
4x61	Lig	peptide_off	5.45736	0	1	0	1	0
4x65	E2x52	Shared	4.17835	5.14663	0	0	2	1
6x51	7x41	Shared	3.71357	3.7476	1	1	1	2
3x33	4x61	Shared	5.95688	6.20077	1	1	1	1
4x61	5x39	Shared	4.69374	2.97579	1	0	1	2
6x57	E3	Shared	3.51422	2.97748	0	0	2	1
2x56	3x32	Shared	3.4204	4.81396	0	0	2	1
1x35	7x35	Shared	3.34003	5.0089	0	0	2	2
6x51	7x37	peptide_off	3.24668	0	1	1	1	2
6x61	E3	Shared	3.15511	4.21264	0	0	2	1
5x40	Lig	peptide_off	2.96394	0	1	0	1	0
7x30	E3	Shared	2.69974	2.73035	1	0	2	1
7x31	7x35	peptide_off	2.48276	0	0	0	1	2
6x58	E3	peptide_off	2.36074	0	1	0	1	1
5x34	5x35	peptide_off	2.14549	0	0	1	2	2
5x32	E2	peptide_off	1.97389	0	0	0	2	1
2x67	NT	peptide_off	1.76175	0	0	1	1	1
7x27	7x30	peptide_off	1.57578	0	0	0	1	2
E1	E2	peptide_off	1.45903	0	0	1	1	1
7x26	7x30	peptide_off	1.42592	0	0	1	2	2
6x58	6x62	peptide_off	0.971945	0	1	0	1	2
7x28	NT	peptide_off	0.867431	0	0	0	2	1
5x29	E3	Shared	0.813333	0.75138	0	0	2	1
7x24	NT	Shared	0.707778	0.579091	0	0	2	1
7x25	E3	peptide_off	0.657222	0	0	0	2	1
5x31	5x34	peptide_off	0.591736	0	0	0	2	2
1x24	7x27	peptide_off	0.364722	0	0	1	1	1
1x23	1x24	peptide_off	0.338333	0	0	0	2	1
2x68	E2	peptide_off	0.316667	0	0	0	1	1
6x63	E3	peptide_off	0.271458	0	0	0	2	1
5x28	Lig	peptide_off	0.1525	0	0	1	1	0
6x64	E3	Shared	0.0708333	0.209545	0	0	2	1
2x64	7x35	peptide_on	0	3.37174	0	1	1	2
3x40	6x48	peptide_on	0	4.44723	0	0	2	1
E2	Lig	peptide_on	0	17.525	1	1	1	0
5x43	Lig	peptide_on	0	4.51633	0	0	1	0
7x31	Lig	peptide_on	0	6.86022	0	0	1	0
7x34	7x38	peptide_on	0	3.41414	1	1	1	1
7x38	7x42	peptide_on	0	3.74209	1	1	1	2
6x54	7x37	peptide_on	0	3.2511	0	0	2	2
E2x51	Lig	peptide_on	0	5.85594	0	1	1	0
2x63	Lig	peptide_on	0	5.13565	0	1	1	0
E3	Lig	peptide_on	0	7.23384	1	1	1	0
7x27	Lig	peptide_on	0	3.71243	0	0	1	0
Lig	NT	peptide_on	0	4.02538	1	1	0	1
2x64	Lig	peptide_on	0	3.24162	0	1	1	0
E2x52	Lig	peptide_on	0	4.64885	1	1	1	0
E1	Lig	peptide_on	0	3.45263	0	1	1	0
3x33	3x37	peptide_on	0	2.89951	1	1	1	2
5x36	6x59	peptide_on	0	2.24059	0	1	2	2
5x32	5x35	peptide_on	0	2.16963	0	0	2	2
7x26	E3	peptide_on	0	1.89473	0	1	2	1
2x67	Lig	peptide_on	0	1.88713	0	1	1	0
1x32	2x67	peptide_on	0	1.61929	0	0	2	1
5x34	E2	peptide_on	0	1.53837	0	1	2	1
5x31	E2	peptide_on	0	1.3478	0	0	2	1
6x62	E2	peptide_on	0	0.826364	0	0	2	1
5x40	5x41	peptide_on	0	0.792955	1	0	1	2
1x23	E2	peptide_on	0	0.728636	0	0	2	1
7x25	7x26	peptide_on	0	0.66125	0	0	2	2
1x21	E2	peptide_on	0	0.426818	0	0	2	1
5x28	E2	peptide_on	0	0.419318	0	1	1	1
2x68	Lig	peptide_on	0	0.302045	0	0	1	0
6x59	6x63	peptide_on	0	0.279886	0	0	2	2
1x24	Lig	peptide_on	0	0.270455	0	1	1	0
5x27	E2	peptide_on	0	0.238003	0	1	2	1
1x24	1x25	peptide_on	0	0.212386	0	1	1	2
3x20	E1	peptide_on	0	0.191742	0	0	2	1
5x25	5x28	peptide_on	0	0.128669	0	0	2	1
2x70	E1	peptide_on	0	0.00590909	0	0	2	1
2x69	E1	peptide_on	0	0.00542424	0	0	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	peptide_off	opioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
	peptide_on	opioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on

Network Difference
Value	peptide_off	peptide_on
I_min	3.68168	3.12175
Number of Linked Nodes	311	333
Number of Specific Nodes	6 (1.93%)	28 (8.41%)
Number of Shared Nodes	305 (98.07%)	305 (91.59%)
Number of Links	324	355
Number of Specific Links	130 (40.12%)	161 (45.35%)
Number of Shared Links	194 (59.88%)	194 (54.65%)
Number of Hubs	28	33
Number of Specific Hubs	9 (32.14%)	14 (42.42%)
Number of Shared Hubs	19 (67.86%)	19 (57.58%)
Average % Shared Neighbours (Jaccard)	42.34
Average % Shared Neighbours (Otsuka)	50.14
Average % Shared Neighbours (Overlap Coefficient)	58.77
Average % Shared Cliques (k3-6)	77.94
Graphlets Similarity	0.400362

Paths Difference
Value	peptide_off	peptide_on
Number Of Nodes in MetaPath	65	49
Specific Nodes in MetaPath	31 (47.69%)	15 (30.61%)
Shared Nodes in MetaPath	305 (98.07%)	305 (98.07%)
Number Of Links MetaPath	65	50
Specific Links in MetaPath	45 (69.23%)	30 (60.00%)
Shared Links in MetaPath	194 (59.88%)	194 (59.88%)
Number of Shortest Paths	44760	65654
Length Of Smallest Path	3	3
Average Path Length	14.5286	12.3652
Length of Longest Path	34	26
Minimum Path Strength	0.572431	0.350121
Average Path Strength	4.79777	4.41051
Maximum Path Strength	10.735	12.4571
Minimum Path Correlation	0.700194	0.700949
Average Path Correlation	0.900304	0.901425
Maximum Path Correlation	0.985764	0.987109
Minimum % Of Corr. Nodes	3.22581	4.34783
Average % Of Corr. Nodes	39.9654	41.915
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	30.2193	41.1861
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

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