Orange: nodes, hubs and links specific of rhodopsin_on_gp network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of rhodopsin_off network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.


Index Hub Owner rhodopsin_on_gp Avg Int. Strength rhodopsin_off Avg Int. Strength rhodopsin_on_gp Num Of Links rhodopsin_off Num Of Links ConSurf
1NT.N8 rhodopsin_on_gp4.66510.07414
2NT.F9 rhodopsin_on_gp8.1869.98778537
3NT.Y10 rhodopsin_on_gp6.5926.37778537
4NT.V11 rhodopsin_on_gp3.1664.78889538
51x32 rhodopsin_on_gp3.656.65535
61x38 rhodopsin_on_gp11.096.25333414
71x42 rhodopsin_on_gp7.715.35833427
81x49 rhodopsin_on_gp3.14752.15222438
91x50 rhodopsin_on_gp5.057.13333439
101x55 rhodopsin_on_gp7.3759.39667413
111x56 rhodopsin_on_gp3.12255.54222437
122x39 rhodopsin_on_gp3.76257.45418
132x42 rhodopsin_on_gp5.015.79222437
142x45 rhodopsin_on_gp5.8768.36111539
152x46 rhodopsin_on_gp4.48257.1429
16E1x50 rhodopsin_on_gp6.9489.41444538
173x38 rhodopsin_on_gp4.306676.51111637
183x54 rhodopsin_on_gp2.6756.87222438
19I2x54 rhodopsin_on_gp6.30757.99333425
204x48 rhodopsin_on_gp3.855.90333423
214x49 rhodopsin_on_gp3.6766.10167527
224x60 rhodopsin_on_gp8.148.49111435
23E2.W175 rhodopsin_on_gp7.092511.2044435
24E2.R177 rhodopsin_on_gp9.042511.7411435
25E2.M183 rhodopsin_on_gp4.19756.72667432
26E2x50 rhodopsin_on_gp4.87756.94889439
27E2x52 rhodopsin_on_gp4.375.42444634
28E2.T193 rhodopsin_on_gp5.1085710.2267725
295x43 rhodopsin_on_gp5.7654.97333615
305x47 rhodopsin_on_gp4.7055.61333428
315x51 rhodopsin_on_gp4.99753.45667437
325x57 rhodopsin_on_gp3.37753.14833428
335x58 rhodopsin_on_gp5.072.95111539
346x26 rhodopsin_on_gp6.451.90667425
356x40 rhodopsin_on_gp7.1645.165528
36E3.F283 rhodopsin_on_gp7.3786.31111534
377x35 rhodopsin_on_gp2.3857.59167424
387x48 rhodopsin_on_gp4.28510.615625
397x52 rhodopsin_on_gp3.34754.90667418
407x54 rhodopsin_on_gp5.00756.31667417
41G.HN.43 rhodopsin_on_gp3.5250409
42G.S1.02 rhodopsin_on_gp4.02750405
43G.S1.05 rhodopsin_on_gp5.67250409
44G.S1.07 rhodopsin_on_gp3.3380509
45G.s1h1.01 rhodopsin_on_gp2.1940509
46G.s1h1.05 rhodopsin_on_gp2.5550409
47G.H1.01 rhodopsin_on_gp5.9440509
48G.S2.01 rhodopsin_on_gp4.31250408
49G.S2.04 rhodopsin_on_gp2.5550407
50G.S2.06 rhodopsin_on_gp7.5680508
51G.S3.03 rhodopsin_on_gp4.18250407
52G.S3.04 rhodopsin_on_gp8.3160507
53G.S3.06 rhodopsin_on_gp8.228330606
54G.s3h2.03 rhodopsin_on_gp5.0040509
55G.H2.06 rhodopsin_on_gp5.818570709
56G.H2.07 rhodopsin_on_gp5.676670609
57G.H2.10 rhodopsin_on_gp4.8550407
58G.h2s4.01 rhodopsin_on_gp5.9650609
59G.S4.02 rhodopsin_on_gp4.4680508
60G.S4.04 rhodopsin_on_gp5.60509
61G.s4h3.01 rhodopsin_on_gp9.39750407
62G.H3.08 rhodopsin_on_gp5.28750409
63G.H3.09 rhodopsin_on_gp5.568330609
64G.H3.13 rhodopsin_on_gp3.820405
65G.H3.17 rhodopsin_on_gp6.7550604
66G.H3.18 rhodopsin_on_gp4.423330609
67G.S5.01 rhodopsin_on_gp4.86250408
68G.S5.02 rhodopsin_on_gp3.9250406
69G.S5.03 rhodopsin_on_gp3.30250409
70G.S5.05 rhodopsin_on_gp3.753330609
71G.S5.06 rhodopsin_on_gp3.7450608
72G.HG.01 rhodopsin_on_gp6.7980505
73G.HG.08 rhodopsin_on_gp5.03750407
74G.HG.14 rhodopsin_on_gp4.53250405
75G.H4.05 rhodopsin_on_gp5.45250404
76G.H4.10 rhodopsin_on_gp10.82750407
77G.H4.15 rhodopsin_on_gp6.3040508
78G.h4s6.10 rhodopsin_on_gp3.8820504
79G.h4s6.12 rhodopsin_on_gp7.6080504
80G.S6.01 rhodopsin_on_gp5.29750405
81G.S6.02 rhodopsin_on_gp6.477140708
82G.S6.05 rhodopsin_on_gp6.0550405
83G.s6h5.01 rhodopsin_on_gp5.670509
84G.H5.08 rhodopsin_on_gp7.3850408
85G.H5.13 rhodopsin_on_gp8.67250407
86G.H5.14 rhodopsin_on_gp4.86250407
87G.H5.17 rhodopsin_on_gp6.278570706
88G.H5.23 rhodopsin_on_gp3.38750404
89G.H5.26 rhodopsin_on_gp4.48750405
90b.1x11 rhodopsin_on_gp2.71750408
91b.1x19 rhodopsin_on_gp5.3120506
92b.h2x1 rhodopsin_on_gp4.86750405
93b.lhb1x3 rhodopsin_on_gp4.9850402
94b.lhb1x6 rhodopsin_on_gp5.5880503
95b.b1x3 rhodopsin_on_gp4.1750407
96b.b1x4 rhodopsin_on_gp4.820507
97b.l1x3 rhodopsin_on_gp5.265710709
98b.l1x7 rhodopsin_on_gp4.4260509
99b.b2x1 rhodopsin_on_gp7.4180508
100b.b2x5 rhodopsin_on_gp5.894290707
101b.b3x2 rhodopsin_on_gp5.02750405
102b.b3x3 rhodopsin_on_gp4.0580508
103b.l3x1 rhodopsin_on_gp7.95750409
104b.l3x2 rhodopsin_on_gp8.7750409
105b.b4x3 rhodopsin_on_gp5.1040507
106b.b4x4 rhodopsin_on_gp9.1350408
107b.b4x5 rhodopsin_on_gp3.0350607
108b.b4x6 rhodopsin_on_gp9.997140709
109b.b4x7 rhodopsin_on_gp6.77250408
110b.b5x3 rhodopsin_on_gp4.778330609
111b.b5x5 rhodopsin_on_gp5.65750405
112b.b5x7 rhodopsin_on_gp5.3720507
113b.l5x5 rhodopsin_on_gp7.410709
114b.b6x1 rhodopsin_on_gp3.0750409
115b.b6x5 rhodopsin_on_gp4.173750806
116b.l6x3 rhodopsin_on_gp4.210406
117b.b7x2 rhodopsin_on_gp3.2040508
118b.b7x3 rhodopsin_on_gp2.39250409
119b.b7x4 rhodopsin_on_gp4.250408
120b.l7x2 rhodopsin_on_gp3.560409
121b.l7x4 rhodopsin_on_gp4.9250409
122b.b8x3 rhodopsin_on_gp4.1850406
123b.b8x4 rhodopsin_on_gp5.1380506
124b.l8x1 rhodopsin_on_gp5.26750405
125b.l9x3 rhodopsin_on_gp4.8450409
126b.l9x6 rhodopsin_on_gp4.563330608
127b.b10x2 rhodopsin_on_gp3.8150406
128b.b10x3 rhodopsin_on_gp4.2750408
129b.b10x5 rhodopsin_on_gp40509
130b.l10x1 rhodopsin_on_gp4.140403
131b.b11x2 rhodopsin_on_gp4.53750407
132b.b11x3 rhodopsin_on_gp3.7250405
133b.b11x4 rhodopsin_on_gp4.480609
134b.b11x5 rhodopsin_on_gp3.640406
135b.b11x6 rhodopsin_on_gp5.610409
136b.b12x3 rhodopsin_on_gp3.8720508
137b.b12x5 rhodopsin_on_gp3.4480506
138b.b12x6 rhodopsin_on_gp12.14750408
139b.l12x1 rhodopsin_on_gp3.9260506
140b.b13x7 rhodopsin_on_gp6.603330607
141b.l13x3 rhodopsin_on_gp6.464290709
142b.l13x6 rhodopsin_on_gp4.591670609
143b.l13x7 rhodopsin_on_gp4.1020509
144b.b14x1 rhodopsin_on_gp5.26750408
145b.b14x3 rhodopsin_on_gp3.4040505
146b.b15x1 rhodopsin_on_gp6.5980509
147b.b15x3 rhodopsin_on_gp3.9740509
148b.l15x1 rhodopsin_on_gp6.690407
149b.b16x4 rhodopsin_on_gp10.3620506
150b.b16x6 rhodopsin_on_gp8.210708
151b.b17x5 rhodopsin_on_gp9.3150407
152b.b17x7 rhodopsin_on_gp5.740608
153b.l17x3 rhodopsin_on_gp8.068570709
154b.b18x3 rhodopsin_on_gp4.74250408
155b.b18x5 rhodopsin_on_gp3.350605
156b.l18x1 rhodopsin_on_gp7.720806
157b.l18x3 rhodopsin_on_gp9.450405
158b.b19x2 rhodopsin_on_gp5.504290706
159b.b19x4 rhodopsin_on_gp4.7320508
160b.b19x5 rhodopsin_on_gp2.30405
161b.b19x6 rhodopsin_on_gp7.34250409
162b.l19x2 rhodopsin_on_gp9.220409
163b.b20x2 rhodopsin_on_gp4.9640506
164b.b20x3 rhodopsin_on_gp2.2880508
165b.b20x4 rhodopsin_on_gp7.456670608
166b.b20x5 rhodopsin_on_gp5.220407
167b.b20x6 rhodopsin_on_gp3.783330606
168b.l20x2 rhodopsin_on_gp10.4550409
169b.b21x1 rhodopsin_on_gp11.7750407
170b.b21x2 rhodopsin_on_gp6.47750406
171b.b21x5 rhodopsin_on_gp5.6340504
172b.b21x7 rhodopsin_on_gp5.248570705
173b.l21x2 rhodopsin_on_gp7.65250404
174b.l21x5 rhodopsin_on_gp7.1250404
175b.b22x3 rhodopsin_on_gp2.060406
176b.b22x5 rhodopsin_on_gp6.7660507
177b.l22x4 rhodopsin_on_gp3.560409
178b.l22x5 rhodopsin_on_gp6.451250809
179b.b23x2 rhodopsin_on_gp4.6450406
180b.b23x6 rhodopsin_on_gp9.9120507
181b.b24x4 rhodopsin_on_gp9.73250406
182b.b24x6 rhodopsin_on_gp5.8950608
183b.b24x7 rhodopsin_on_gp7.8650409
184b.l24x2 rhodopsin_on_gp5.448330606
185b.l24x3 rhodopsin_on_gp5.03250405
186b.b25x3 rhodopsin_on_gp4.5850605
187b.b25x6 rhodopsin_on_gp4.03750403
188b.l25x3 rhodopsin_on_gp7.7850609
189b.l25x6 rhodopsin_on_gp11.8560508
190b.b26x2 rhodopsin_on_gp3.38250407
191b.b26x3 rhodopsin_on_gp3.7180506
192b.b26x4 rhodopsin_on_gp3.35750405
193b.l26x1 rhodopsin_on_gp7.69250407
194b.b27x3 rhodopsin_on_gp4.62750408
195b.l27x1 rhodopsin_on_gp10.49860709
196b.l27x2 rhodopsin_on_gp7.1280509
197b.b28x3 rhodopsin_on_gp3.7440507
198b.b28x4 rhodopsin_on_gp6.5760506
199b.b28x5 rhodopsin_on_gp3.12750405
200b.b28x6 rhodopsin_on_gp8.9720509
201b.b28x7 rhodopsin_on_gp5.11250409
202g.h2x11 rhodopsin_on_gp5.42750409
203g.h2x12 rhodopsin_on_gp4.39250408
204g.l2x3 rhodopsin_on_gp6.0260508
205g.h3x8 rhodopsin_on_gp6.260404
206g.h3x12 rhodopsin_on_gp3.2150406
207g.l3x4 rhodopsin_on_gp6.8160509
208g.h4x3 rhodopsin_on_gp4.40405
209g.ctx2 rhodopsin_on_gp3.68750406
210g.ctx9 rhodopsin_on_gp4.411430707
211NT.V20 Shared4.6258.99333446
212NT.P23 Shared6.3128.544555
213NT.F24 Shared3.817.15389565
214NT.Q28 Shared6.05256.54133455
215NT.Y30 Shared5.5468.318554
216NT.L31 Shared5.76.56667444
2171x39 Shared3.5066.22167547
218I1x50 Shared6.2756.395447
2192x57 Shared7.0385.20733557
2203x30 Shared3.8955.44917646
2213x37 Shared8.5956.3125446
2223x41 Shared7.868339.32278665
2233x50 Shared5.4627.94722569
2243x51 Shared6.1386.80833547
225I2x56 Shared5.4756.465447
2264x50 Shared4.5626.51549
227E2.Y178 Shared7.484296.84267753
228E2.P180 Shared3.686.04463
229E2.E181 Shared5.338.53733554
230E2.Q184 Shared5.79757.27867453
231E2.D190 Shared7.51810.1733544
232E2.Y191 Shared5.157146.00667766
233E2.Y192 Shared4.778337.85778665
234E2.H195 Shared8.17212.58544
2355x36 Shared4.7047.6825544
2365x39 Shared9.3669.02111566
2375x42 Shared4.733338.4625644
2385x461 Shared5.998578.535766
2396x44 Shared5.96758.2075449
2406x48 Shared8.748.89333568
2416x51 Shared7.336679.82656
2427x34 Shared2.69757.1225444
2437x53 Shared6.7087514.2317849
2448x50 Shared8.12410.1533548
245Lig Shared6.398.69074990
246NT.S22 rhodopsin_off5.113336.63583345
247NT.Y29 rhodopsin_off4.626.97083344
2481x30 rhodopsin_off10.935.43243
2491x47 rhodopsin_off5.574.5625246
2501x59 rhodopsin_off11.4258.77083245
2511x60 rhodopsin_off5.997.09555365
2522x38 rhodopsin_off2.955.19346
2532x41 rhodopsin_off8.077.81667245
254E1x51 rhodopsin_off7.577.25167144
2553x31 rhodopsin_off4.585.232254
2564x41 rhodopsin_off57.405345
2575x37 rhodopsin_off4.666.17833143
258I3.E239 rhodopsin_off08.20667042
2596x31 rhodopsin_off10.86.032154
2607x39 rhodopsin_off9.513338.91345
2617x42 rhodopsin_off8.186678.66583347
2628x47 rhodopsin_off4.063.6225348
2638x48 rhodopsin_off04.3575044
2648x49 rhodopsin_off3.295.505146
2658x54 rhodopsin_off2.9654.58583246
266CT.E332 rhodopsin_off04.64583040
267CT.E341 rhodopsin_off06.86667050
268CT.T342 rhodopsin_off05.01417040
   
Orange: nodes, hubs and links specific of rhodopsin_on_gp network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of rhodopsin_off network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Owner rhodopsin_on_gp Recurrence rhodopsin_off Recurrence rhodopsin_on_gp Hub1? rhodopsin_off Hub1? rhodopsin_on_gp Hub2? rhodopsin_off Hub2? ConSurf1 ConSurf2
11x32 NT.Q28 rhodopsin_on_gp10.78680YesNoYesYes55
27x35 E2.M183 rhodopsin_on_gp24.74162.17817YesNoYesNo42
37x35 E2.G182 rhodopsin_on_gp27.93361.09004YesNoNoNo43
4E2.E181 E2.G182 rhodopsin_on_gp22.53460YesYesNoNo43
5E2.Y191 Lig rhodopsin_on_gp20.32020YesYesYesYes60
66x51 E2.E181 rhodopsin_on_gp17.38542.26837YesYesYesYes64
76x47 7x48 rhodopsin_on_gp11.49940NoNoYesNo85
86x47 6x48 rhodopsin_on_gp16.88176.48077NoNoYesYes88
96x48 6x51 rhodopsin_on_gp12.10550YesYesYesYes86
10G.H3.17 G.H3.18 rhodopsin_on_gp41.46560YesNoYesNo49
11G.H3.18 G.S4.02 rhodopsin_on_gp41.93310YesNoYesNo98
12G.S1.07 G.S4.02 rhodopsin_on_gp37.4120YesNoYesNo98
13G.S1.07 G.s1h1.01 rhodopsin_on_gp1000YesNoYesNo99
14G.H1.01 G.s1h1.01 rhodopsin_on_gp87.08140YesNoYesNo99
15G.H1.01 G.S1.06 rhodopsin_on_gp86.99950YesNoNoNo99
16G.S1.06 G.S3.05 rhodopsin_on_gp86.9670NoNoNoNo97
17G.S2.06 G.S3.05 rhodopsin_on_gp86.57290YesNoNoNo87
18G.S2.06 G.S3.03 rhodopsin_on_gp86.45050YesNoYesNo87
19G.S1.02 G.S3.03 rhodopsin_on_gp85.86880YesNoYesNo57
20G.H5.15 G.S1.02 rhodopsin_on_gp88.98880NoNoYesNo85
21G.H5.15 G.H5.18 rhodopsin_on_gp88.91470NoNoNoNo84
22G.H5.18 G.H5.19 rhodopsin_on_gp88.84050NoNoNoNo48
23G.H5.19 G.H5.22 rhodopsin_on_gp88.76620NoNoNoNo84
242x39 G.H5.22 rhodopsin_on_gp88.69170YesNoNoNo84
252x39 3x49 rhodopsin_on_gp52.51540YesNoNoNo88
262x42 3x49 rhodopsin_on_gp52.64550YesNoNoNo78
272x42 3x45 rhodopsin_on_gp52.49051.8903YesNoNoNo77
283x45 4x48 rhodopsin_on_gp23.16670NoNoYesNo73
293x41 4x48 rhodopsin_on_gp19.58380.769556YesYesYesNo53
303x37 3x41 rhodopsin_on_gp29.00197.18316YesYesYesYes65
31b.l25x6 b.l27x1 rhodopsin_on_gp10.12750YesNoYesNo89
32G.H3.17 b.l25x6 rhodopsin_on_gp22.46910YesNoYesNo48
33b.b2x1 b.l27x1 rhodopsin_on_gp10.33990YesNoYesNo89
34G.H2.10 b.b2x1 rhodopsin_on_gp14.45970YesNoYesNo78
35G.H2.10 G.h2s4.01 rhodopsin_on_gp14.47010YesNoYesNo79
36G.S1.05 G.h2s4.01 rhodopsin_on_gp38.60280YesNoYesNo99
37G.S1.05 G.S1.07 rhodopsin_on_gp38.26640YesNoYesNo99
383x45 4x49 rhodopsin_on_gp29.23270NoNoYesNo77
393x41 4x49 rhodopsin_on_gp19.64620YesYesYesNo57
403x50 G.H5.23 rhodopsin_on_gp32.00190YesYesYesNo94
417x48 7x52 rhodopsin_on_gp14.98880YesNoYesNo58
423x50 7x53 rhodopsin_on_gp22.93140YesYesYesYes99
43G.H5.06 G.S6.02 rhodopsin_on_gp11.23620NoNoYesNo48
44b.b26x2 b.l1x7 rhodopsin_on_gp10.41690YesNoYesNo79
45b.b26x1 b.b26x2 rhodopsin_on_gp29.1820NoNoYesNo97
46b.b26x1 b.l27x1 rhodopsin_on_gp29.4030NoNoYesNo99
47G.H3.08 G.S1.07 rhodopsin_on_gp17.84650YesNoYesNo99
48G.S5.07 G.s1h1.06 rhodopsin_on_gp14.01740NoNoNoNo99
49G.S5.07 G.s6h5.01 rhodopsin_on_gp13.64420NoNoYesNo99
50G.H2.07 G.s3h2.03 rhodopsin_on_gp26.57320YesNoYesNo99
51G.H2.04 G.H2.07 rhodopsin_on_gp20.56820NoNoYesNo99
52G.H2.04 G.H3.08 rhodopsin_on_gp20.55370NoNoYesNo99
53G.H2.07 G.h2s4.01 rhodopsin_on_gp18.11140YesNoYesNo99
54G.H2.07 b.l7x2 rhodopsin_on_gp11.98580YesNoYesNo99
55G.s3h2.03 b.l9x6 rhodopsin_on_gp25.90030YesNoYesNo98
56G.H2.06 b.l9x6 rhodopsin_on_gp12.9550YesNoYesNo98
57G.H2.06 b.l19x1 rhodopsin_on_gp12.59920YesNoNoNo99
58G.HG.04 G.HG.08 rhodopsin_on_gp10.90240NoNoYesNo97
59b.l17x5 b.l19x1 rhodopsin_on_gp18.35880NoNoNoNo69
60b.b19x6 b.l17x5 rhodopsin_on_gp16.6340YesNoNoNo96
61b.b19x6 b.l17x3 rhodopsin_on_gp15.30660YesNoYesNo99
62b.b20x6 b.l17x3 rhodopsin_on_gp10.56910YesNoYesNo69
63b.b26x2 b.b2x3 rhodopsin_on_gp18.1030YesNoNoNo76
64b.b2x3 b.b2x5 rhodopsin_on_gp16.2790NoNoYesNo67
65b.b6x1 b.l7x2 rhodopsin_on_gp17.83380YesNoYesNo99
66b.b6x1 b.l7x1 rhodopsin_on_gp23.87320YesNoNoNo99
67b.b7x5 b.l7x1 rhodopsin_on_gp23.64480NoNoNoNo99
68b.b7x4 b.b7x5 rhodopsin_on_gp14.59850YesNoNoNo89
69b.b4x3 b.b7x4 rhodopsin_on_gp11.43770YesNoYesNo78
702x39 G.H5.23 rhodopsin_on_gp34.53780YesNoYesNo84
71G.s1h1.05 G.s1h1.06 rhodopsin_on_gp14.08010YesNoNoNo99
72G.s1h1.01 G.s1h1.05 rhodopsin_on_gp14.1510YesNoYesNo99
731x32 E2.M183 Shared18.348619.0662YesNoYesNo52
743x37 Lig Shared28.61122.3209YesYesYesYes60
75E2.Y191 E2.Y192 rhodopsin_off4.1595212.6468YesYesYesYes65
76E2.Y191 E2x52 rhodopsin_off029.911YesYesYesNo64
775x39 E2x52 rhodopsin_off0.11281244.8779YesYesYesNo64
785x39 E2.S176 rhodopsin_off4.2763579.4542YesYesNoNo65
795x36 E2.S176 rhodopsin_off3.6224978.107YesYesNoNo45
805x36 E2.D190 rhodopsin_off0.071822869.6745YesYesYesYes44
81E2.D190 E2.I179 rhodopsin_off0.0023958364.0957YesYesNoNo41
82E2.I179 E2.P180 rhodopsin_off063.1266NoNoYesYes13
83E2.P180 E2.Q184 rhodopsin_off2.1109923.8658YesYesYesYes33
84E2.P180 NT.P23 rhodopsin_off1.3119822.3651YesYesYesYes35
85E2.P180 NT.F24 rhodopsin_off0.021562510.5243YesYesYesYes35
86NT.P23 NT.Q28 rhodopsin_off013.7445YesYesYesYes55
87E2.Q184 NT.Q28 rhodopsin_off1.2640613.4874YesYesYesYes35
88NT.Q28 NT.Y30 rhodopsin_off4.8183812.1267YesYesYesYes54
89NT.L31 NT.Q28 rhodopsin_off5.916612.073YesYesYesYes45
906x51 Lig rhodopsin_off7.8761821.8872YesYesYesYes60
917x42 Lig rhodopsin_off0.53135350.2629NoYesYesYes70
927x39 7x42 rhodopsin_off033.1178NoYesNoYes57
931x35 7x39 rhodopsin_off025.1017NoNoNoYes55
941x35 E2.M183 rhodopsin_off1.071322.0791NoNoYesNo52
951x32 NT.Y29 rhodopsin_off6.4199316.9782YesNoNoYes54
966x51 E2.Y191 rhodopsin_off0.25203115.7001YesYesYesYes66
972x57 7x42 rhodopsin_off0.26260417.3179YesYesNoYes77
981x39 2x61 rhodopsin_off018.2256YesYesNoNo76
991x53 7x50 rhodopsin_off010.4072NoNoNoNo99
1001x53 8x50 rhodopsin_off0.0043229112.0807NoNoYesYes98
1017x53 8x50 rhodopsin_off022.7431YesYesYesYes98
1022x43 7x53 rhodopsin_off052.1225NoNoYesYes89
1032x43 6x40 rhodopsin_off052.4756NoNoYesNo88
1046x40 7x49 rhodopsin_off052.9093YesNoNoNo89
1052x46 7x49 rhodopsin_off054.4408YesNoNoNo99
1062x46 3x42 rhodopsin_off0.14005254.9896YesNoNoNo98
1073x42 4x49 rhodopsin_off093.69NoNoYesNo87
1082x45 4x49 rhodopsin_off0.3990193.9971YesNoYesNo97
1092x45 4x50 rhodopsin_off0.0001562594.5997YesNoYesYes99
1102x52 4x50 rhodopsin_off0.1437596.039NoNoYesYes69
1112x52 3x31 rhodopsin_off096.5879NoNoNoYes64
1123x30 3x31 rhodopsin_off0.64880198.6298YesYesNoYes64
1133x30 4x61 rhodopsin_off0.23666699.3322YesYesNoNo65
1143x26 4x61 rhodopsin_off0.117599.7812NoNoNoNo75
1153x26 E2.Y178 rhodopsin_off0.139114100NoNoYesYes73
116E2.Y178 E2x52 rhodopsin_off0.67963446.8527YesYesYesNo34
1171x60 I1x50 rhodopsin_off0.2767717.5405NoYesYesYes57
1182x40 I1x50 rhodopsin_off020.2099NoNoYesYes87
1192x40 7x53 rhodopsin_off020.3404NoNoYesYes89
1208x47 8x49 rhodopsin_off013.6563NoYesNoYes86
1217x53 8x47 rhodopsin_off017.9205YesYesNoYes98
1221x60 CT.S338 rhodopsin_off011.2747NoYesNoNo50
1232x38 3x49 rhodopsin_off012.3302NoYesNoNo68
1243x49 3x50 rhodopsin_off018.4578NoNoYesYes89
1253x50 6x37 rhodopsin_off037.8157YesYesNoNo98
1263x46 6x37 rhodopsin_off038.2072NoNoNoNo98
1272x42 3x46 rhodopsin_off0.34828138.6332YesNoNoNo79
1282x42 3x42 rhodopsin_off040.464YesNoNoNo78
1293x33 E2.Y178 rhodopsin_off0.12552157.0814NoNoYesYes43
1303x33 Lig rhodopsin_off056.7974NoNoYesYes40
1316x48 Lig rhodopsin_off0.76781112.8829YesYesYesYes80
1323x37 5x461 rhodopsin_off0.045781211.7314YesYesYesYes66
1335x42 5x461 rhodopsin_off4.5605113.852YesYesYesYes46
1345x39 5x42 rhodopsin_off2.4609314.8327YesYesYesYes64
1353x50 6x34 rhodopsin_off030.1144YesYesNoNo96
1363x54 5x65 rhodopsin_off012.0615YesNoNoNo88
1375x65 6x34 rhodopsin_off029.3659NoNoNoNo86
1384x60 E2.Y178 rhodopsin_off0.18005232.3367YesNoYesYes53
1394x60 5x39 rhodopsin_off030.9492YesNoYesYes56
1405x65 6x31 rhodopsin_off017.6787NoNoNoYes84

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Midway



Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Node1Node2OwnerNet1LinkStrengthNet2LinkStrengthComm1Comm2Node1ShellNode2Shell
1x392x57Shared6.224.980222
1x392x60Shared9.033333.010222
1x397x39rhodopsin_off5.3933300222
2x533x35rhodopsin_off4.6566700012
2x537x46Shared4.293334.830012
2x577x42Shared8.279.930221
2x603x28rhodopsin_off11.2900021
3x287x42rhodopsin_off8.5502011
3x28Ligrhodopsin_off4.9166702010
3x32LigShared6.046673.140010
3x33E2.Y178Shared5.826674.990212
3x33Ligrhodopsin_off8.7800210
3x366x48rhodopsin_off4.6900021
3x373x40rhodopsin_off6.6302212
3x373x41Shared5.813337.632212
3x375x461Shared7.3911.082212
3x37LigShared5.416673.522210
3x406x44Shared10.154.870222
3x415x461Shared4.936678.462222
4x565x461Shared13.26677.370222
4x60E2.Y178Shared11.593318.082222
4x605x39rhodopsin_off6.7402222
E2.Y178E2x52Shared6.446674.840221
E2.E181E2.Y191Shared5.9833310.12221
E2.E181E2.Y192Shared11.59674.492222
6x51E2.E181Shared9.726672.242212
7x34E2.E181rhodopsin_off9.9233302222
E2.Y191E2x52rhodopsin_off5.6402211
5x39E2x52Shared4.186675.022221
E2.Y191E2.Y192Shared5.6266710.922212
6x51E2.Y191Shared6.953.972211
6x55E2.Y191Shared8.896671.330021
7x34E2.Y192rhodopsin_off3.9902222
5x395x42Shared7.223334.132222
5x425x461Shared11.61334.362222
5x435x44rhodopsin_off4.9733300212
5x475x51Shared4.873332.440212
5x47Ligrhodopsin_off6.3533300210
6x446x48Shared16.379.020221
6x487x41rhodopsin_off6.4833300212
6x487x45rhodopsin_off8.2366700212
6x48LigShared14.09673.790210
6x517x34rhodopsin_off7.9833302212
6x51LigShared21.7720.272210
6x547x34rhodopsin_off6.5933300022
6x547x37rhodopsin_off6.4800022
7x397x42rhodopsin_off9.100221
7x42LigShared8.7433310.312210
2x532x57rhodopsin_off3.7333300012
6x476x48Shared3.483336.530221
5x40E2.Y191rhodopsin_off2.9433300021
6x517x38rhodopsin_off2.6702212
6x52Ligrhodopsin_off2.0933300210
6x526x53rhodopsin_off1.300212
1x397x42rhodopsin_on_gp04.320221
2x533x36rhodopsin_on_gp03.490012
2x53Ligrhodopsin_on_gp01.880010
2x563x28rhodopsin_on_gp04.910021
2x577x46rhodopsin_on_gp02.770222
2x593x28rhodopsin_on_gp011.290021
3x28E2x50rhodopsin_on_gp06.082012
3x334x57rhodopsin_on_gp03.360212
3x33E2x52rhodopsin_on_gp04.560211
3x353x36rhodopsin_on_gp02.110022
3x374x56rhodopsin_on_gp012.152212
3x406x48rhodopsin_on_gp020.50221
4x565x43rhodopsin_on_gp03.240221
4x60E2x52rhodopsin_on_gp05.082221
5x43E2x52rhodopsin_on_gp02.920211
E2x52Ligrhodopsin_on_gp03.80210
6x54E2.Y191rhodopsin_on_gp05.050021
7x34E2.Y191rhodopsin_on_gp02.392221
E2.Y191Ligrhodopsin_on_gp02.342210
5x395x43rhodopsin_on_gp012.442221
5x425x43rhodopsin_on_gp03.592221
5x435x461rhodopsin_on_gp03.940212
5x43Ligrhodopsin_on_gp08.460210
5x445x47rhodopsin_on_gp04.290221
5x445x48rhodopsin_on_gp03.770222
5x446x52rhodopsin_on_gp02.770221
5x475x48rhodopsin_on_gp03.770212
5x476x52rhodopsin_on_gp08.320211
5x516x44rhodopsin_on_gp02.440222
6x477x45rhodopsin_on_gp05.160222
6x486x51rhodopsin_on_gp03.860211
6x517x37rhodopsin_on_gp08.342212
6x517x41rhodopsin_on_gp05.342212

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
Id Description
rhodopsin_on_gp 6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
rhodopsin_off 1U19-Rhodopsin-11-cis-Retinal
2PED-Rhodopsin-9-cis-Retinal
5TE5-Rhodopsin-20-Methanoretinal
Network Difference
Value rhodopsin_on_gp rhodopsin_off
Imin 1.71 3.98667
Number of Linked Nodes 876 347
Number of Specific Nodes 583 (66.55%) 54  (15.56%)
Number of Shared Nodes 293 (33.45%) 293  (84.44%)
Number of Links 1199 399
Number of Specific Links 1018 (84.90%) 218  (54.64%)
Number of Shared Links 181 (15.10%) 181  (45.36%)
Number of Hubs 245 58
Number of Specific Hubs 210 (85.71%) 23  (39.66%)
Number of Shared Hubs 35 (14.29%) 35  (60.34%)
Average % Shared Neighbours (Jaccard) 11.38
Average % Shared Neighbours (Otsuka) 14.70
Average % Shared Neighbours (Overlap Coefficient) 17.93
Average % Shared Cliques (k3-6) 51.05
Graphlets Similarity 0.711895
Paths Difference
Value rhodopsin_on_gp rhodopsin_off
Number Of Nodes in MetaPath 75 66
Specific Nodes in MetaPath 62 (82.67%) 53  (80.30%)
Shared Nodes in MetaPath 293 (33.45%) 293  (33.45%)
Number Of Links MetaPath 74 68
Specific Links in MetaPath 72 (97.30%) 66  (97.06%)
Shared Links in MetaPath 181 (15.10%) 181  (15.10%)
Number of Shortest Paths 2565888 103239
Length Of Smallest Path 3 3
Average Path Length 29.1918 18.4548
Length of Longest Path 50 37
Minimum Path Strength 1.27 0.751667
Average Path Strength 5.2532 7.19037
Maximum Path Strength 24.215 22.8433
Minimum Path Correlation 0.7 0.7
Average Path Correlation 0.99021 0.937289
Maximum Path Correlation 1 1
Minimum % Of Corr. Nodes 2.94118 3.125
Average % Of Corr. Nodes 43.0907 47.1766
Maximum % Of Corr. Nodes 100 100
Minimum Path Hubs % 0 0
Average Path Hubs % 61.6346 44.4792
Maximum Path Hubs % 100 100

Details about the values in these tables can be found in the corresponding documentation page .

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

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