psnGPCR

Press and hold down the left mouse button and move the mouse to rotate.
Press and hold down the central mouse button and move the mouse to translate.
Use the mouse wheel to zoom in or out.
Click on any atom on your molecule and the corresponding residue label will be placed beneath the viewer.

Orange: nodes, hubs and links specific of s1p1_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of s1p1_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	s1p1_off Int. Strength	s1p1_on Int. Strength	s1p1_off Hub1?	s1p1_on Hub1?	s1p1_off Hub2?	s1p1_on Hub2?	ConSurf1	ConSurf2
1	7x35	Lig	s1p1_off	6.32	0	No	No	Yes	Yes	3	0
2	NT.I24	NT.Y19	s1p1_off	4.84	0	Yes	No	No	No	4	8
3	E2.I185	NT.Y19	s1p1_off	6.04	0	Yes	No	No	No	3	8
4	3x21	NT.V20	s1p1_off	4.76	0	No	No	No	No	7	5
5	NT.D23	NT.N21	s1p1_off	4.04	0	No	No	No	No	7	8
6	NT.I24	NT.N21	s1p1_off	4.25	0	Yes	No	No	No	4	8
7	3x21	NT.Y22	s1p1_off	7.49	0	No	No	No	No	7	5
8	E2.I185	NT.I24	s1p1_off	4.42	0	Yes	No	Yes	No	3	4
9	E2.L197	NT.I25	s1p1_off	4.28	0	No	No	No	No	4	4
10	E2.C191	NT.H28	s1p1_off	5.9	0	No	No	Yes	Yes	9	8
11	E1x50	NT.Y29	s1p1_off	6.24	0	No	No	Yes	Yes	5	7
12	NT.L35	NT.N36	s1p1_off	4.12	0	Yes	No	No	No	6	4
13	1x53	7x53	s1p1_off	3.79	0	No	No	No	No	9	9
14	1x57	I1x50	s1p1_off	5.02	0	No	No	Yes	Yes	7	8
15	1x57	2x40	s1p1_off	6.04	0	No	No	No	Yes	7	9
16	8x50	I1x50	s1p1_off	3.73	0	No	Yes	Yes	Yes	8	8
17	2x37	2x38	s1p1_off	5.76	0	No	No	No	No	7	7
18	2x38	3x49	s1p1_off	4.72	0	No	No	No	Yes	7	9
19	2x39	6x33	s1p1_off	5.65	0	No	Yes	No	No	8	8
20	2x41	4x43	s1p1_off	8.25	0	No	No	No	No	4	2
21	2x43	3x46	s1p1_off	4.42	0	No	No	No	No	8	8
22	2x43	7x53	s1p1_off	6.04	0	No	No	No	No	8	9
23	2x46	7x49	s1p1_off	5.49	0	No	Yes	No	No	9	9
24	2x49	3x39	s1p1_off	4.89	0	No	No	No	No	8	9
25	2x49	4x50	s1p1_off	6.18	0	No	No	Yes	No	8	9
26	2x57	2x60	s1p1_off	9.3	0	Yes	Yes	Yes	No	6	5
27	2x60	2x64	s1p1_off	7.45	0	Yes	No	No	No	5	4
28	2x60	3x29	s1p1_off	5.26	0	Yes	No	Yes	Yes	5	5
29	2x63	E1x52	s1p1_off	6.92	0	No	No	No	No	4	5
30	2x64	3x28	s1p1_off	3.95	0	No	No	Yes	Yes	4	6
31	3x28	E1x52	s1p1_off	4.86	0	Yes	Yes	No	No	6	5
32	3x26	E2.I185	s1p1_off	5.02	0	Yes	Yes	Yes	No	6	3
33	3x33	E2.Y198	s1p1_off	14.44	0	No	No	Yes	Yes	5	4
34	3x36	5x47	s1p1_off	7.31	0	No	No	Yes	No	6	7
35	3x37	3x41	s1p1_off	5.28	0	Yes	No	No	No	6	5
36	3x37	5x47	s1p1_off	5.28	0	Yes	No	Yes	No	6	7
37	3x40	5x47	s1p1_off	6.55	0	No	No	Yes	No	7	7
38	3x43	6x41	s1p1_off	6.92	0	No	No	Yes	No	9	7
39	3x46	6x37	s1p1_off	4.61	0	No	No	No	No	8	8
40	3x49	3x52	s1p1_off	4.1	0	No	Yes	No	No	9	4
41	3x50	3x53	s1p1_off	3.88	0	Yes	Yes	No	No	9	8
42	3x50	6x34	s1p1_off	7.29	0	Yes	Yes	No	No	9	8
43	4x59	5x39	s1p1_off	5.86	0	No	No	Yes	Yes	5	7
44	5x36	E2.C184	s1p1_off	5.9	0	No	No	No	No	4	5
45	6x58	E2.T193	s1p1_off	8.67	0	Yes	Yes	No	No	4	5
46	7x32	E2.T193	s1p1_off	5.19	0	No	No	No	No	1	5
47	5x40	E2.L195	s1p1_off	5.71	0	No	No	No	Yes	6	3
48	5x44	6x56	s1p1_off	4.42	0	No	No	No	No	5	6
49	5x52	5x56	s1p1_off	4.28	0	No	No	No	No	4	4
50	5x54	5x58	s1p1_off	4.84	0	No	No	Yes	Yes	8	9
51	5x54	6x41	s1p1_off	4.28	0	No	No	Yes	No	8	7
52	5x57	5x61	s1p1_off	5.71	0	No	No	No	No	7	9
53	5x58	6x37	s1p1_off	3.79	0	Yes	Yes	No	No	9	8
54	5x58	6x38	s1p1_off	9.67	0	Yes	Yes	No	No	9	5
55	6x26	6x29	s1p1_off	10.47	0	No	No	No	No	4	6
56	6x29	6x30	s1p1_off	5.26	0	No	No	No	No	6	7
57	6x29	8x49	s1p1_off	12.69	0	No	No	No	No	6	7
58	6x33	8x47	s1p1_off	6.87	0	No	No	Yes	No	8	8
59	6x33	8x49	s1p1_off	3.98	0	No	No	No	No	8	7
60	6x36	8x47	s1p1_off	7.31	0	No	No	Yes	No	9	8
61	6x39	7x56	s1p1_off	4.56	0	No	No	No	No	6	7
62	6x40	7x49	s1p1_off	7.39	0	No	No	No	No	8	9
63	6x47	7x40	s1p1_off	4.76	0	No	No	No	No	8	7
64	6x48	6x52	s1p1_off	8.02	0	Yes	Yes	Yes	Yes	8	6
65	6x51	6x55	s1p1_off	5.54	0	No	No	No	No	6	6
66	6x51	7x38	s1p1_off	4.15	0	No	No	No	No	6	5
67	E3.K285	E3.V284	s1p1_off	4.55	0	No	No	No	No	2	1
68	7x33	7x35	s1p1_off	10.47	0	No	No	No	No	4	3
69	7x35	7x38	s1p1_off	7.95	0	No	No	No	No	3	5
70	7x53	8x50	s1p1_off	5.99	0	No	No	No	Yes	9	8
71	7x54	8x54	s1p1_off	3.89	0	No	No	No	No	7	7
72	8x47	8x49	s1p1_off	9.2	0	Yes	No	No	No	8	7
73	5x62	6x35	s1p1_off	3.58	0	No	Yes	No	No	6	7
74	1x53	7x50	s1p1_off	3.53	0	No	No	Yes	No	9	9
75	4x58	4x61	s1p1_off	3.53	0	No	No	No	No	4	5
76	6x24	6x27	s1p1_off	3.42	0	No	No	No	No	2	4
77	3x23	NT.V20	s1p1_off	3.39	0	No	No	No	No	2	5
78	1x60	8x53	s1p1_off	3.36	0	No	No	No	No	6	7
79	E2.S189	E2.S190	s1p1_off	3.26	0	No	No	No	No	4	4
80	6x61	7x31	s1p1_off	3.17	0	No	No	Yes	Yes	4	3
81	1x38	1x42	s1p1_off	3.07	0	No	No	No	No	5	6
82	5x40	6x59	s1p1_off	3.07	0	No	No	No	Yes	6	4
83	3x37	4x56	s1p1_off	3	0	Yes	No	No	No	6	5
84	NT.L35	NT.V26	s1p1_off	2.98	0	Yes	No	No	No	6	6
85	5x45	5x49	s1p1_off	2.95	0	No	No	No	No	4	5
86	7x54	7x55	s1p1_off	2.95	0	No	No	No	No	7	6
87	1x47	1x51	s1p1_off	2.94	0	No	No	No	No	6	4
88	6x54	7x30	s1p1_off	2.85	0	No	No	No	No	4	3
89	3x54	5x64	s1p1_off	2.83	0	No	No	No	No	8	6
90	1x54	2x48	s1p1_off	2.77	0	No	No	No	No	8	5
91	4x38	4x39	s1p1_off	2.72	0	No	No	No	No	7	1
92	6x25	6x26	s1p1_off	2.64	0	No	No	No	No	4	4
93	7x54	8x51	s1p1_off	2.59	0	No	No	No	No	7	8
94	1x39	1x42	s1p1_off	2.51	0	No	Yes	No	No	6	6
95	3x50	5x61	s1p1_off	2.51	0	Yes	Yes	No	No	9	9
96	4x43	4x46	s1p1_off	2.51	0	No	No	No	No	2	7
97	3x54	5x68	s1p1_off	2.48	0	No	No	No	No	8	7
98	3x34	4x50	s1p1_off	2.45	0	No	No	Yes	No	5	9
99	1x55	1x58	s1p1_off	2.28	0	No	No	No	No	4	3
100	2x48	4x50	s1p1_off	2.28	0	No	No	Yes	No	5	9
101	7x47	7x50	s1p1_off	2.03	0	No	No	Yes	No	7	9
102	1x43	2x54	s1p1_off	1.96	0	No	No	No	No	5	7
103	NT.G33	NT.T32	s1p1_off	1.82	0	No	No	No	No	7	8
104	3x38	4x49	s1p1_off	1.81	0	No	No	No	No	7	6
105	1x47	2x54	s1p1_off	1.76	0	No	No	No	No	6	7
106	6x45	6x46	s1p1_off	1.62	0	No	No	No	No	6	5
107	2x56	3x32	s1p1_off	1.61	0	No	No	No	No	4	6
108	1x35	1x36	s1p1_off	1.6	0	No	No	No	No	5	5
109	6x32	8x47	s1p1_off	1.56	0	No	No	Yes	No	7	8
110	1x36	1x40	s1p1_off	1.55	0	No	No	No	No	5	3
111	6x38	6x42	s1p1_off	1.55	0	No	No	No	No	5	5
112	5x63	5x64	s1p1_off	1.5	0	No	No	No	No	3	6
113	2x58	2x62	s1p1_off	1.47	0	No	No	No	No	6	6
114	5x41	5x45	s1p1_off	1.47	0	No	No	No	No	5	4
115	NT.D18	NT.V20	s1p1_off	1.46	0	No	No	No	No	6	5
116	1x48	1x51	s1p1_off	1.43	0	No	No	No	No	4	4
117	6x53	6x57	s1p1_off	1.43	0	No	No	No	No	5	4
118	4x59	4x62	s1p1_off	1.41	0	No	No	No	No	5	4
119	2x37	3x56	s1p1_off	1.24	0	No	No	No	No	7	6
120	Lig	NT.Y29	Shared	8.79	3.16286	Yes	Yes	Yes	Yes	0	7
121	Lig	NT.K34	Shared	5.77	3.31714	Yes	Yes	No	No	0	6
122	2x60	Lig	Shared	12.17	6.04143	Yes	No	Yes	Yes	5	0
123	3x29	Lig	Shared	14.45	8.36714	Yes	Yes	Yes	Yes	5	0
124	3x32	Lig	Shared	15.42	4.12143	No	No	Yes	Yes	6	0
125	3x33	Lig	Shared	15.77	21.7043	No	No	Yes	Yes	5	0
126	3x36	Lig	Shared	3.77	8.20286	No	No	Yes	Yes	6	0
127	6x48	Lig	Shared	5.43	5.19571	Yes	Yes	Yes	Yes	8	0
128	7x38	Lig	Shared	17.93	9.01857	No	No	Yes	Yes	5	0
129	NT.H28	NT.I24	Shared	5.3	3.21857	Yes	Yes	Yes	No	8	4
130	3x22	NT.I24	Shared	6.77	2.90286	No	No	Yes	No	3	4
131	NT.H28	NT.R27	Shared	4.51	4.35143	Yes	Yes	No	No	8	3
132	E2.L188	NT.H28	Shared	6.43	3.30714	No	No	Yes	Yes	2	8
133	NT.K34	NT.Y29	Shared	5.97	5.97286	No	No	Yes	Yes	6	7
134	E1x501	NT.Y29	Shared	5.96	4.39571	No	Yes	Yes	Yes	5	7
135	3x25	NT.Y29	Shared	10.61	4.68286	Yes	Yes	Yes	Yes	9	7
136	E2.P196	NT.Y29	Shared	20.86	11.5229	No	No	Yes	Yes	3	7
137	NT.L35	NT.N30	Shared	5.49	2.35571	Yes	No	No	No	6	9
138	E2.L188	NT.Y31	Shared	10.55	8.70857	No	No	No	No	2	5
139	E3.V284	NT.Y31	Shared	12.62	2.70286	No	No	No	No	1	5
140	E2.P196	NT.T32	Shared	5.25	5.24571	No	No	No	No	3	8
141	E1x501	NT.L35	Shared	4.69	1.00429	No	Yes	Yes	No	5	6
142	1x39	7x39	Shared	3.93	13.1086	No	Yes	No	No	6	5
143	1x40	2x61	Shared	7.14	3.46429	No	No	No	Yes	3	5
144	1x45	1x49	Shared	8.16	7.16429	No	No	No	No	4	8
145	1x46	7x47	Shared	5.29	6.79857	No	No	No	No	7	7
146	1x49	7x50	Shared	11	3.36714	No	No	Yes	No	8	9
147	1x50	2x47	Shared	4.69	2.00857	Yes	Yes	No	Yes	9	9
148	1x50	2x50	Shared	4.04	7.30714	Yes	Yes	Yes	Yes	9	9
149	1x50	7x50	Shared	8.15	4.42428	Yes	Yes	Yes	No	9	9
150	1x52	8x54	Shared	8.57	3.52143	No	No	No	No	7	7
151	1x60	I1x50	Shared	19.46	10.7471	No	No	Yes	Yes	6	8
152	2x40	I1x50	Shared	22.69	22.99	No	Yes	Yes	Yes	9	8
153	2x41	I1x51	Shared	4.36	4.66857	No	No	No	No	4	7
154	2x39	2x43	Shared	5.83	2.71	No	Yes	No	No	8	8
155	2x39	3x50	Shared	11.17	3.72	No	Yes	Yes	Yes	8	9
156	2x42	3x45	Shared	5.55	2.77	Yes	Yes	No	No	8	7
157	2x42	3x49	Shared	12.83	10.4929	Yes	Yes	No	Yes	8	9
158	2x42	4x42	Shared	3.65	6.78714	Yes	Yes	No	Yes	8	7
159	2x45	3x42	Shared	4.47	4.47	No	No	No	No	9	8
160	2x45	4x46	Shared	8.5	6.06857	No	No	No	No	9	7
161	2x45	4x50	Shared	9.04	7.10286	No	No	Yes	No	9	9
162	2x46	3x42	Shared	6.01	6.22143	No	Yes	No	No	9	8
163	2x50	3x39	Shared	4.42	3.57571	Yes	Yes	No	No	9	9
164	2x50	7x46	Shared	11.78	8.62428	Yes	Yes	No	No	9	9
165	2x50	7x49	Shared	5.39	4.04	Yes	Yes	No	No	9	9
166	2x57	2x61	Shared	10.55	9.71286	Yes	Yes	No	Yes	6	5
167	2x57	3x32	Shared	5.99	4.61714	Yes	Yes	No	No	6	6
168	2x57	7x42	Shared	18.93	9.91286	Yes	Yes	No	No	6	7
169	E1x49	E1x51	Shared	9.01	1.71429	No	No	No	No	4	1
170	3x28	E1x50	Shared	7.76	4.61857	Yes	Yes	No	No	6	5
171	3x24	E1x52	Shared	6.65	8.74714	No	No	No	No	4	5
172	3x21	3x24	Shared	15.59	5.06286	No	No	No	No	7	4
173	3x25	3x28	Shared	10	6.85714	Yes	Yes	Yes	Yes	9	6
174	3x25	3x29	Shared	8.72	15.5771	Yes	Yes	Yes	Yes	9	5
175	3x25	E2.L197	Shared	15.94	10.0871	Yes	Yes	No	No	9	4
176	3x25	E2.Y198	Shared	6.75	3.44429	Yes	Yes	Yes	Yes	9	4
177	3x26	4x61	Shared	3.77	4.84571	Yes	Yes	No	No	6	5
178	3x26	E2.N183	Shared	12.08	9.14857	Yes	Yes	No	No	6	5
179	3x26	E2.L197	Shared	9.74	8.00286	Yes	Yes	No	No	6	4
180	3x26	E2.Y198	Shared	4.13	3.24286	Yes	Yes	Yes	Yes	6	4
181	3x28	3x29	Shared	12.79	5.48571	Yes	Yes	Yes	Yes	6	5
182	3x33	5x39	Shared	10.32	4.71714	No	No	Yes	Yes	5	7
183	3x34	4x54	Shared	4.47	4.04429	No	No	No	No	5	4
184	3x36	6x48	Shared	17.08	5.04286	No	No	Yes	Yes	6	8
185	3x37	4x53	Shared	6.52	3.26	Yes	No	No	No	6	8
186	3x38	4x50	Shared	7.78	4.26	No	No	Yes	No	7	9
187	3x41	5x50	Shared	3.65	11.1357	No	No	No	No	5	8
188	3x43	6x44	Shared	8.53	3.65429	No	No	Yes	Yes	9	9
189	3x44	5x54	Shared	4.28	5.09714	No	Yes	No	No	7	8
190	3x47	5x58	Shared	5.34	4.57429	No	No	Yes	Yes	8	9
191	3x51	5x60	Shared	7.2	7.34857	No	Yes	No	No	8	5
192	3x51	5x61	Shared	6.04	3.62714	No	Yes	No	No	8	9
193	3x54	5x65	Shared	4.56	2.38857	No	No	No	No	8	8
194	4x38	4x41	Shared	4.82	6.54571	No	No	No	No	7	5
195	4x59	E2.W182	Shared	4.56	4.39286	No	No	No	Yes	5	5
196	4x60	E2.Y198	Shared	11.13	10.3329	No	No	Yes	Yes	5	4
197	4x60	5x39	Shared	11.13	13.1157	No	No	Yes	Yes	5	7
198	5x39	E2.W182	Shared	14.47	5.78714	Yes	Yes	No	Yes	7	5
199	5x42	E2.W182	Shared	8.02	3.00714	No	No	No	Yes	5	5
200	E2.I185	E2.N183	Shared	11.33	8.69857	Yes	No	No	No	3	5
201	E2.C184	E2.C191	Shared	7.28	7.28	No	No	No	No	5	9
202	5x36	E2.S190	Shared	9.76	8.96571	No	No	No	No	4	4
203	6x58	E2.S192	Shared	7.36	3.99714	Yes	Yes	No	No	4	4
204	7x31	E2.T193	Shared	8.84	4.84571	Yes	Yes	No	No	3	5
205	E2.L195	E2.V194	Shared	4.47	4.47	No	Yes	No	No	3	4
206	6x58	E2.V194	Shared	4.38	5.42286	Yes	Yes	No	No	4	4
207	E2.L195	E2.Y198	Shared	11.72	6.36428	No	Yes	Yes	Yes	3	4
208	5x39	E2.Y198	Shared	7.94	4.11286	Yes	Yes	Yes	Yes	7	4
209	5x36	5x38	Shared	11.94	12.2829	No	No	No	No	4	4
210	5x39	5x43	Shared	9.41	7.68	Yes	Yes	No	No	7	6
211	5x40	6x55	Shared	5.71	4.28	No	No	No	No	6	6
212	5x41	6x59	Shared	7.45	5.96	No	No	No	Yes	5	4
213	5x42	5x46	Shared	7.87	3.74571	No	No	No	No	5	5
214	5x44	6x52	Shared	3.89	3.70571	No	No	Yes	Yes	5	6
215	5x47	6x52	Shared	6.43	6.73571	Yes	No	Yes	Yes	7	6
216	5x48	6x52	Shared	3.89	3.14857	No	Yes	Yes	Yes	4	6
217	5x51	6x44	Shared	6.09	3.65286	No	No	Yes	Yes	5	9
218	5x51	6x45	Shared	5.71	3.67	No	No	No	No	5	6
219	5x58	6x41	Shared	4.69	4.02	Yes	Yes	Yes	No	9	7
220	5x62	5x66	Shared	8.23	6.90857	No	Yes	No	No	6	5
221	6x36	7x56	Shared	7.85	5.38286	No	No	No	No	9	7
222	6x39	7x52	Shared	4.42	2.10143	No	No	No	No	6	8
223	6x43	7x48	Shared	6.35	1.59	No	No	No	No	7	5
224	6x44	6x48	Shared	14.03	8.01714	Yes	Yes	Yes	Yes	9	8
225	6x44	7x45	Shared	8.46	3.45286	Yes	Yes	No	Yes	9	9
226	6x47	7x45	Shared	9.45	8.32286	No	No	No	Yes	8	9
227	6x48	7x41	Shared	10.37	1.66714	Yes	Yes	No	No	8	7
228	6x48	7x45	Shared	5.65	8.55571	Yes	Yes	No	Yes	8	9
229	6x50	7x40	Shared	4.93	4.22143	No	No	No	No	9	7
230	6x54	7x37	Shared	4.87	10.96	No	No	No	No	4	4
231	6x58	7x31	Shared	12.21	5.42714	Yes	Yes	Yes	Yes	4	3
232	6x61	E3.C287	Shared	7.28	7.28	No	No	No	No	4	3
233	E3.K283	E3.T286	Shared	4.5	2.78571	No	No	No	No	1	1
234	7x33	7x36	Shared	7.2	2.20571	No	No	No	No	4	3
235	7x39	7x43	Shared	4.47	1.06429	No	No	No	No	5	6
236	8x47	8x50	Shared	9.82	9.41572	Yes	No	No	Yes	8	8
237	8x48	8x51	Shared	13.61	6.01143	No	No	No	No	6	8
238	5x60	5x64	Shared	3.64	3.64143	No	No	No	No	5	6
239	1x58	1x59	Shared	3.48	2.15429	No	No	No	No	3	6
240	2x52	4x50	Shared	3.42	2.44286	No	No	Yes	No	6	9
241	2x56	3x31	Shared	3.42	1.71	No	No	No	No	4	4
242	E2.A187	E2.S190	Shared	3.42	2.19857	No	No	No	No	4	4
243	7x34	E2.V194	Shared	3.39	1.7	No	No	No	No	4	4
244	1x43	2x58	Shared	3.38	3.13857	No	No	No	No	5	6
245	7x31	E3.C287	Shared	3.17	3.85429	Yes	Yes	No	No	3	3
246	6x43	7x52	Shared	3.07	4.61	No	No	No	No	7	8
247	1x60	I1x49	Shared	3	3.85857	No	No	No	No	6	6
248	1x59	8x57	Shared	2.91	2.7	No	No	No	No	6	6
249	6x50	7x37	Shared	2.89	3.92143	No	No	No	No	9	4
250	7x51	7x55	Shared	2.85	2.24	No	No	No	No	6	6
251	1x50	2x51	Shared	2.75	5.49429	Yes	Yes	No	No	9	6
252	1x49	7x51	Shared	2.73	7.02571	No	No	No	No	8	6
253	1x56	8x54	Shared	2.59	2.96286	No	No	No	No	8	7
254	2x57	7x39	Shared	2.52	3.96714	Yes	Yes	No	No	6	5
255	3x41	4x52	Shared	2.51	5.92143	No	No	No	No	5	4
256	2x42	4x45	Shared	2.44	5.56714	Yes	Yes	No	No	8	6
257	4x40	4x44	Shared	2.44	2.78286	No	No	No	No	4	3
258	3x51	3x55	Shared	2.34	4.52286	No	Yes	No	No	8	6
259	4x57	4x58	Shared	2.11	2.11	No	No	No	No	6	4
260	2x37	2x40	Shared	2.06	12.9343	No	No	No	Yes	7	9
261	2x44	2x47	Shared	1.95	1.95	No	No	No	Yes	5	9
262	2x53	2x54	Shared	1.95	1.67143	No	No	No	No	8	7
263	6x49	6x50	Shared	1.87	1.87	No	No	No	No	6	9
264	2x64	E1x47	Shared	1.86	2.12286	No	No	No	No	4	4
265	2x53	3x35	Shared	1.79	1.79	No	No	No	No	8	6
266	2x53	7x46	Shared	1.71	1.71	No	No	No	No	8	9
267	4x63	E2.N183	Shared	1.7	1.45429	No	No	No	No	5	5
268	4x48	4x52	Shared	1.62	0.694286	No	No	No	No	3	4
269	1x37	1x38	Shared	1.6	0.228571	No	No	No	No	5	5
270	6x57	6x61	Shared	1.59	3.40143	No	No	No	No	4	4
271	1x47	2x55	Shared	1.54	2.19429	No	No	No	No	6	5
272	4x51	4x55	Shared	1.54	1.09857	No	No	No	No	4	4
273	1x56	8x57	Shared	1.52	1.30286	No	No	No	No	8	6
274	5x37	6x59	Shared	1.52	4.77286	No	No	No	Yes	3	4
275	6x31	6x35	Shared	1.52	0.604286	No	No	No	No	5	7
276	5x55	6x41	Shared	1.49	4.68286	No	No	Yes	No	4	7
277	3x30	E2.Y198	Shared	1.45	1.24286	No	No	Yes	Yes	6	4
278	3x48	5x57	Shared	1.43	2.44429	No	No	No	No	6	7
279	2x64	Lig	s1p1_on	0	3.79857	No	No	Yes	Yes	4	0
280	3x37	Lig	s1p1_on	0	5.04429	Yes	No	Yes	Yes	6	0
281	5x47	Lig	s1p1_on	0	6.10571	Yes	No	Yes	Yes	7	0
282	6x51	Lig	s1p1_on	0	6.06286	No	No	Yes	Yes	6	0
283	6x55	Lig	s1p1_on	0	5.25143	No	No	Yes	Yes	6	0
284	E2.L197	NT.H28	s1p1_on	0	5.69286	No	No	Yes	Yes	4	8
285	1x36	2x61	s1p1_on	0	4.71714	No	No	No	Yes	5	5
286	1x38	1x39	s1p1_on	0	3.55571	No	No	No	Yes	5	6
287	1x39	2x57	s1p1_on	0	3.39	No	Yes	Yes	Yes	6	6
288	1x39	2x61	s1p1_on	0	3.13143	No	Yes	No	Yes	6	5
289	1x43	2x57	s1p1_on	0	4.22571	No	No	Yes	Yes	5	6
290	1x47	2x51	s1p1_on	0	4.28	No	No	No	No	6	6
291	1x48	1x52	s1p1_on	0	3.13143	No	No	No	No	4	7
292	I1x48	I1x51	s1p1_on	0	4.67857	No	No	No	No	6	7
293	8x49	I1x49	s1p1_on	0	8.1	No	No	No	No	7	6
294	8x49	I1x50	s1p1_on	0	6.33143	No	No	Yes	Yes	7	8
295	2x37	2x39	s1p1_on	0	4.25143	No	No	No	Yes	7	8
296	2x38	4x42	s1p1_on	0	3.98714	No	No	No	Yes	7	7
297	2x39	3x49	s1p1_on	0	6.57429	No	Yes	No	Yes	8	9
298	2x40	8x47	s1p1_on	0	4.98143	No	Yes	Yes	No	9	8
299	2x40	8x49	s1p1_on	0	5.13	No	Yes	No	No	9	7
300	2x40	8x50	s1p1_on	0	5.30143	No	Yes	No	Yes	9	8
301	2x41	4x42	s1p1_on	0	4.69	No	No	No	Yes	4	7
302	2x46	2x50	s1p1_on	0	4.26429	No	Yes	Yes	Yes	9	9
303	2x46	3x43	s1p1_on	0	3.36	No	Yes	No	No	9	9
304	2x46	3x46	s1p1_on	0	3.25857	No	Yes	No	No	9	8
305	2x57	7x38	s1p1_on	0	4.68857	Yes	Yes	No	No	6	5
306	2x60	3x28	s1p1_on	0	10.5043	Yes	No	Yes	Yes	5	6
307	2x60	3x32	s1p1_on	0	6.21143	Yes	No	No	No	5	6
308	2x63	3x28	s1p1_on	0	3.98857	No	No	Yes	Yes	4	6
309	E1x50	E1x501	s1p1_on	0	5.17429	No	No	No	Yes	5	5
310	3x21	3x22	s1p1_on	0	4.74857	No	No	No	No	7	3
311	3x25	E2.L195	s1p1_on	0	3.09286	Yes	Yes	No	Yes	9	3
312	3x29	E2.L195	s1p1_on	0	4.16857	Yes	Yes	No	Yes	5	3
313	3x29	E2.Y198	s1p1_on	0	5.61143	Yes	Yes	Yes	Yes	5	4
314	3x33	5x43	s1p1_on	0	3.19143	No	No	No	No	5	6
315	3x38	4x53	s1p1_on	0	3.42	No	No	No	No	7	8
316	3x40	5x50	s1p1_on	0	3.40571	No	No	No	No	7	8
317	3x40	6x48	s1p1_on	0	4.02714	No	No	Yes	Yes	7	8
318	3x41	4x49	s1p1_on	0	3.19286	No	No	No	No	5	6
319	3x44	3x48	s1p1_on	0	6.32286	No	Yes	No	No	7	6
320	3x44	5x50	s1p1_on	0	3.36	No	Yes	No	No	7	8
321	3x46	3x50	s1p1_on	0	4.83286	No	No	Yes	Yes	8	9
322	3x46	7x53	s1p1_on	0	6.73286	No	No	No	No	8	9
323	3x49	3x53	s1p1_on	0	3.82714	No	Yes	No	No	9	8
324	3x49	4x41	s1p1_on	0	5.31714	No	Yes	No	No	9	5
325	3x50	5x58	s1p1_on	0	5.73143	Yes	Yes	Yes	Yes	9	9
326	3x50	7x53	s1p1_on	0	6.17143	Yes	Yes	No	No	9	9
327	3x51	5x57	s1p1_on	0	5.52714	No	Yes	No	No	8	7
328	3x52	4x41	s1p1_on	0	7.69571	No	No	No	No	4	5
329	3x54	5x61	s1p1_on	0	3.54143	No	No	No	No	8	9
330	5x68	I2x50	s1p1_on	0	8.86286	No	No	No	No	7	0
331	4x42	4x46	s1p1_on	0	3.87143	No	Yes	No	No	7	7
332	5x36	E2.W182	s1p1_on	0	3.62857	No	No	No	Yes	4	5
333	5x40	6x58	s1p1_on	0	3.6	No	No	Yes	Yes	6	4
334	5x47	6x48	s1p1_on	0	11.4543	Yes	No	Yes	Yes	7	8
335	5x62	6x33	s1p1_on	0	3.34857	No	Yes	No	No	6	8
336	5x62	6x34	s1p1_on	0	11.8886	No	Yes	No	No	6	8
337	5x64	5x68	s1p1_on	0	5.9	No	No	No	No	6	7
338	5x65	6x33	s1p1_on	0	4.47	No	No	No	No	8	8
339	5x66	5x70	s1p1_on	0	5.02429	No	No	No	No	5	0
340	6x52	6x56	s1p1_on	0	5.39286	Yes	Yes	No	No	6	6
341	6x54	7x31	s1p1_on	0	3.36286	No	No	Yes	Yes	4	3
342	7x45	7x49	s1p1_on	0	6.81143	No	Yes	No	No	9	9
343	7x54	8x50	s1p1_on	0	8.81571	No	No	No	Yes	7	8
344	E2.L195	Lig	s1p1_on	0	5.89714	No	Yes	Yes	Yes	3	0
345	1x55	1x59	s1p1_on	0	3.22286	No	No	No	No	4	6
346	3x56	I2x51	s1p1_on	0	5.54286	No	No	No	No	6	0
347	7x35	7x36	s1p1_on	0	7.21429	No	No	No	No	3	3
348	I3.F237	I3.R238	s1p1_on	0	4.27571	No	No	No	No	0	0
349	4x39	4x43	s1p1_on	0	2.93429	No	No	No	No	1	2
350	2x49	3x38	s1p1_on	0	2.93143	No	No	No	No	8	7
351	1x54	2x47	s1p1_on	0	2.92714	No	No	No	Yes	8	9
352	3x53	I2x54	s1p1_on	0	2.92429	No	No	No	No	8	0
353	6x58	6x59	s1p1_on	0	2.92	Yes	Yes	No	Yes	4	4
354	1x46	1x50	s1p1_on	0	2.83286	No	No	Yes	Yes	7	9
355	2x38	I2x56	s1p1_on	0	2.8	No	No	No	No	7	0
356	5x73	I3.K239	s1p1_on	0	2.78857	No	No	No	No	0	0
357	8x53	I1x50	s1p1_on	0	2.77	No	No	Yes	Yes	7	8
358	E2.C184	NT.H28	s1p1_on	0	2.73714	No	No	Yes	Yes	5	8
359	E2.S189	NT.Y31	s1p1_on	0	2.72714	No	No	No	No	4	5
360	5x62	6x30	s1p1_on	0	2.72714	No	Yes	No	No	6	7
361	E1x501	NT.N36	s1p1_on	0	2.65857	No	Yes	No	No	5	4
362	1x51	2x51	s1p1_on	0	2.64857	No	No	No	No	4	6
363	NT.I25	NT.Y29	s1p1_on	0	2.59286	No	No	Yes	Yes	4	7
364	5x58	6x40	s1p1_on	0	2.52286	Yes	Yes	No	No	9	8
365	4x61	4x62	s1p1_on	0	2.5	No	No	No	No	5	4
366	4x56	5x43	s1p1_on	0	2.49143	No	No	No	No	5	6
367	5x60	5x63	s1p1_on	0	2.44857	No	No	No	No	5	3
368	6x34	6x38	s1p1_on	0	2.44571	No	No	No	No	8	5
369	5x71	5x72	s1p1_on	0	2.42857	No	No	No	No	0	0
370	4x38	4x40	s1p1_on	0	2.41714	No	No	No	No	7	4
371	3x44	5x53	s1p1_on	0	2.35714	No	Yes	No	No	7	6
372	1x57	8x50	s1p1_on	0	2.29286	No	No	No	Yes	7	8
373	E3.K285	NT.G33	s1p1_on	0	2.24143	No	No	No	No	2	7
374	6x61	E3.T286	s1p1_on	0	2.17286	No	No	No	No	4	1
375	6x33	6x37	s1p1_on	0	2.12857	No	No	No	No	8	8
376	8x48	8x52	s1p1_on	0	2.12143	No	No	No	No	6	5
377	5x72	5x74	s1p1_on	0	2.08714	No	No	No	No	0	0
378	3x34	4x53	s1p1_on	0	2.07714	No	No	No	No	5	8
379	4x58	4x60	s1p1_on	0	2.03	No	No	No	No	4	5
380	1x53	2x47	s1p1_on	0	1.93857	No	No	No	Yes	9	9
381	3x21	3x23	s1p1_on	0	1.92	No	No	No	No	7	2
382	1x39	7x36	s1p1_on	0	1.91571	No	Yes	No	No	6	3
383	7x29	7x32	s1p1_on	0	1.87571	No	No	No	No	3	1
384	1x35	1x39	s1p1_on	0	1.85286	No	No	No	Yes	5	6
385	I2x52	I2x53	s1p1_on	0	1.83714	No	No	No	No	0	0
386	8x54	8x55	s1p1_on	0	1.79429	No	No	No	No	7	3
387	2x48	2x52	s1p1_on	0	1.77857	No	No	No	No	5	6
388	5x55	5x59	s1p1_on	0	1.71	No	No	No	No	4	3
389	I2x54	I2x55	s1p1_on	0	1.69857	No	No	No	No	0	0
390	5x68	5x71	s1p1_on	0	1.67571	No	No	No	No	7	0
391	5x67	5x71	s1p1_on	0	1.66286	No	No	No	No	5	0
392	6x28	6x30	s1p1_on	0	1.64286	No	Yes	No	No	5	7
393	6x59	6x60	s1p1_on	0	1.57714	No	Yes	No	No	4	4
394	7x52	7x53	s1p1_on	0	1.55571	No	No	No	No	8	9
395	7x29	7x33	s1p1_on	0	1.53	No	No	No	No	3	4
396	4x39	I2x56	s1p1_on	0	1.49	No	No	No	No	1	0
397	1x40	1x44	s1p1_on	0	1.40571	No	No	No	No	3	5
398	3x22	NT.Y22	s1p1_on	0	1.39	No	No	No	No	3	5
399	5x69	5x73	s1p1_on	0	1.37143	No	No	No	No	0	0
400	6x36	6x40	s1p1_on	0	1.36286	No	No	No	No	9	8
401	5x45	5x48	s1p1_on	0	1.34571	No	No	No	Yes	4	4
402	2x56	3x35	s1p1_on	0	1.27857	No	No	No	No	4	6
403	5x72	5x73	s1p1_on	0	1.26429	No	No	No	No	0	0
404	3x52	3x56	s1p1_on	0	1.24571	No	No	No	No	4	6
405	6x27	6x28	s1p1_on	0	1.23286	No	No	No	Yes	4	5
406	6x57	7x30	s1p1_on	0	1.22571	No	No	No	No	4	3
407	6x53	6x56	s1p1_on	0	1.22286	No	No	No	No	5	6
408	7x55	8x51	s1p1_on	0	1.21286	No	No	No	No	6	8
409	5x48	5x49	s1p1_on	0	1.05143	No	Yes	No	No	4	5
410	1x42	1x46	s1p1_on	0	1.05	No	No	No	No	6	7
411	1x40	2x62	s1p1_on	0	1.02	No	No	No	No	3	6
412	4x51	4x52	s1p1_on	0	0.88	No	No	No	No	4	4
413	7x32	NT.G33	s1p1_on	0	0.861429	No	No	No	No	1	7
414	NT.D23	NT.V26	s1p1_on	0	0.834286	No	No	No	No	7	6
415	I3.I241	I3.K239	s1p1_on	0	0.83	No	No	No	No	0	0
416	3x27	4x61	s1p1_on	0	0.817143	No	No	No	No	4	5
417	1x51	1x55	s1p1_on	0	0.815714	No	No	No	No	4	4
418	8x52	8x56	s1p1_on	0	0.761429	No	No	No	No	5	4
419	I2x53	I2x54	s1p1_on	0	0.728571	No	No	No	No	0	0
420	6x42	6x43	s1p1_on	0	0.694286	No	No	No	No	5	7
421	E2.I185	E2.S186	s1p1_on	0	0.664286	Yes	No	No	No	3	1
422	1x38	1x41	s1p1_on	0	0.638571	No	No	No	No	5	4
423	6x28	6x31	s1p1_on	0	0.568571	No	Yes	No	No	5	5
424	E1x501	E1x51	s1p1_on	0	0.511429	No	Yes	No	No	5	1
425	NT.D23	NT.R27	s1p1_on	0	0.51	No	No	No	No	7	3
426	5x48	5x52	s1p1_on	0	0.42	No	Yes	No	No	4	4
427	1x33	E1x47	s1p1_on	0	0.248571	No	No	No	No	0	4
428	2x58	2x59	s1p1_on	0	0.24	No	No	No	No	6	7
429	4x47	4x51	s1p1_on	0	0.231429	No	No	No	No	4	4
430	E1x48	E1x51	s1p1_on	0	0.23	No	No	No	No	4	1
431	6x28	6x32	s1p1_on	0	0.215714	No	Yes	No	No	5	7
432	1x34	1x35	s1p1_on	0	0.21	No	No	No	No	4	5
433	5x56	5x57	s1p1_on	0	0.204286	No	No	No	No	4	7
434	6x28	6x29	s1p1_on	0	0.192857	No	Yes	No	No	5	6

Orange: nodes, hubs and links specific of s1p1_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of s1p1_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	s1p1_off Avg Int. Strength	s1p1_on Avg Int. Strength	s1p1_off Num Of Links	s1p1_on Num Of Links	ConSurf
1	NT.I24	s1p1_off	5.116	3.06071	5	2	4
2	NT.L35	s1p1_off	4.32	1.68	4	2	6
3	2x60	s1p1_off	8.545	7.58571	4	3	5
4	3x37	s1p1_off	5.02	4.15214	4	2	6
5	4x50	s1p1_off	5.19167	4.6019	6	3	9
6	E2.I185	s1p1_off	6.7025	4.68143	4	2	3
7	5x47	s1p1_off	6.3925	8.09857	4	3	7
8	6x41	s1p1_off	4.345	4.35143	4	2	7
9	7x50	s1p1_off	6.1775	3.89571	4	2	9
10	8x47	s1p1_off	6.952	7.19857	5	2	8
11	Lig	Shared	10.582	6.75276	10	15	0
12	NT.H28	Shared	5.535	3.86143	4	5	8
13	NT.Y29	Shared	9.73833	5.38833	6	6	7
14	1x50	Shared	4.9075	4.41343	4	5	9
15	I1x50	Shared	12.725	10.7096	4	4	8
16	2x42	Shared	6.1175	6.40429	4	4	8
17	2x50	Shared	6.4075	5.56229	4	5	9
18	2x57	Shared	9.458	5.78776	5	7	6
19	3x25	Shared	10.404	7.29024	5	6	9
20	3x26	Shared	6.948	6.31	5	4	6
21	3x28	Shared	7.872	6.29086	5	5	6
22	3x29	Shared	10.305	7.842	4	5	5
23	3x50	Shared	6.2125	5.11393	4	4	9
24	E2.Y198	Shared	8.22286	4.90735	7	7	4
25	5x39	Shared	9.855	7.08257	6	5	7
26	5x58	Shared	5.666	4.21214	5	4	9
27	6x44	Shared	9.2775	4.69429	4	4	9
28	6x48	Shared	10.0967	6.28	6	7	8
29	6x52	Shared	5.5575	4.74571	4	4	6
30	6x58	Shared	8.155	4.27343	4	5	4
31	7x31	Shared	6.8475	4.3725	4	4	3
32	1x39	s1p1_on	3.22	4.49238	2	6	6
33	2x39	s1p1_on	7.55	4.31393	3	4	8
34	2x40	s1p1_on	10.2633	10.2674	3	5	9
35	2x46	s1p1_on	5.75	4.27607	2	4	9
36	2x47	s1p1_on	3.32	2.20607	2	4	9
37	2x61	s1p1_on	8.845	5.25643	2	4	5
38	E1x501	s1p1_on	5.325	2.74886	2	5	5
39	3x44	s1p1_on	4.28	4.28429	1	4	7
40	3x49	s1p1_on	7.21667	6.55286	3	4	9
41	3x51	s1p1_on	5.19333	5.25643	3	4	8
42	4x42	s1p1_on	3.65	4.83393	1	4	7
43	E2.W182	s1p1_on	9.01667	4.20393	3	4	5
44	E2.L195	s1p1_on	7.3	4.79857	3	5	3
45	5x48	s1p1_on	3.89	1.49143	1	4	4
46	5x62	s1p1_on	5.905	6.21821	2	4	6
47	6x28	s1p1_on	0	0.770571	0	5	5
48	6x59	s1p1_on	4.01333	3.8075	3	4	4
49	7x45	s1p1_on	7.85333	6.78571	3	4	9
50	8x50	s1p1_on	6.51333	6.45643	3	4	8

Orange: nodes, hubs and links specific of s1p1_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of s1p1_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	s1p1_off Recurrence	s1p1_on Recurrence	s1p1_off Hub1?	s1p1_on Hub1?	s1p1_off Hub2?	s1p1_on Hub2?	ConSurf1	ConSurf2
1	3x33	E2.Y198	s1p1_off	43.0034	0	No	No	Yes	Yes	5	4
2	3x26	E2.I185	s1p1_off	28.5786	0	Yes	Yes	Yes	No	6	3
3	E2.I185	NT.I24	s1p1_off	25.8341	0	Yes	No	Yes	No	3	4
4	3x28	E1x52	s1p1_off	11.876	0	Yes	Yes	No	No	6	5
5	E2.C191	NT.H28	s1p1_off	11.018	0	No	No	Yes	Yes	9	8
6	1x39	7x39	s1p1_off	11.4545	0.115109	No	Yes	No	No	6	5
7	2x57	7x39	s1p1_off	17.1241	4.55502	Yes	Yes	No	No	6	5
8	2x57	2x60	s1p1_off	19.8485	0	Yes	Yes	Yes	No	6	5
9	2x60	Lig	s1p1_off	16.798	2.50937	Yes	No	Yes	Yes	5	0
10	1x53	7x50	s1p1_off	63.3586	0	No	No	Yes	No	9	9
11	1x53	7x53	s1p1_off	64.0359	0	No	No	No	No	9	9
12	2x43	7x53	s1p1_off	77.7733	0	No	No	No	No	8	9
13	2x43	3x46	s1p1_off	97.2054	0	No	No	No	No	8	8
14	3x46	6x37	s1p1_off	97.5265	0	No	No	No	No	8	8
15	5x58	6x37	s1p1_off	97.8727	0	Yes	Yes	No	No	9	8
16	5x58	6x41	s1p1_off	97.7221	3.79859	Yes	Yes	Yes	No	9	7
17	3x43	6x41	s1p1_off	99.8043	0	No	No	Yes	No	9	7
18	7x54	7x55	s1p1_off	13.4915	0	No	No	No	No	7	6
19	7x51	7x55	s1p1_off	14.786	6.45925	No	No	No	No	6	6
20	1x49	7x51	s1p1_off	16.0704	7.73203	No	No	No	No	8	6
21	8x50	I1x50	s1p1_off	20.576	0	No	Yes	Yes	Yes	8	8
22	7x53	8x50	s1p1_off	30.6407	0	No	No	No	Yes	9	8
23	2x40	I1x50	s1p1_off	13.8026	3.73939	No	Yes	Yes	Yes	9	8
24	2x49	4x50	s1p1_off	16.8531	0	No	No	Yes	No	8	9
25	2x49	3x39	s1p1_off	18.0774	0	No	No	No	No	8	9
26	2x50	3x39	s1p1_off	19.3016	1.30237	Yes	Yes	No	No	9	9
27	2x39	2x43	s1p1_off	30.8163	1.30895	No	Yes	No	No	8	8
28	2x39	6x33	s1p1_off	14.5351	0	No	Yes	No	No	8	8
29	2x50	7x46	s1p1_off	14.786	7.73203	Yes	Yes	No	No	9	9
30	3x36	5x47	s1p1_off	11.9362	0	No	No	Yes	No	6	7
31	3x37	5x47	s1p1_off	14.3244	0	Yes	No	Yes	No	6	7
32	3x50	5x61	s1p1_off	15.6139	0	Yes	Yes	No	No	9	9
33	5x40	6x59	s1p1_off	11.5599	0	No	No	No	Yes	6	4
34	6x48	6x52	s1p1_off	11.5248	0	Yes	Yes	Yes	Yes	8	6
35	8x47	8x50	s1p1_off	13.2708	0.00657765	Yes	No	No	Yes	8	8
36	6x36	8x47	s1p1_off	13.4213	0	No	No	Yes	No	9	8
37	6x36	7x56	s1p1_off	11.2087	1.14122	No	No	No	No	9	7
38	2x53	2x54	s1p1_off	10.8725	1.30237	No	No	No	No	8	7
39	2x53	7x46	s1p1_off	13.4915	6.45925	No	No	No	No	8	9
40	3x33	Lig	Shared	51.6733	12.3068	No	No	Yes	Yes	5	0
41	3x26	E2.Y198	Shared	32.2914	14.6616	Yes	Yes	Yes	Yes	6	4
42	3x29	Lig	Shared	10.5263	26.4027	Yes	Yes	Yes	Yes	5	0
43	NT.H28	NT.I24	Shared	20.0793	18.3714	Yes	Yes	Yes	No	8	4
44	Lig	NT.Y29	Shared	12.0365	24.8471	Yes	Yes	Yes	Yes	0	7
45	2x57	3x32	Shared	14.1287	28.7443	Yes	Yes	No	No	6	6
46	3x32	Lig	Shared	17.6659	27.8728	No	No	Yes	Yes	6	0
47	2x57	2x61	Shared	11.4545	11.3432	Yes	Yes	No	Yes	6	5
48	1x49	7x50	Shared	18.6092	10.2578	No	No	Yes	No	8	9
49	3x43	6x44	Shared	100	44.7017	No	No	Yes	Yes	9	9
50	6x44	6x48	Shared	95.5446	46.0731	Yes	Yes	Yes	Yes	9	8
51	6x48	Lig	Shared	88.2695	100	Yes	Yes	Yes	Yes	8	0
52	1x50	7x50	Shared	47.835	11.5109	Yes	Yes	Yes	No	9	9
53	1x50	2x50	Shared	43.761	36.1573	Yes	Yes	Yes	Yes	9	9
54	2x45	4x46	Shared	10.4009	14.6254	No	No	No	No	9	7
55	2x50	7x49	Shared	11.4997	36.5158	Yes	Yes	No	No	9	9
56	2x37	2x40	Shared	12.478	12.2344	No	No	No	Yes	7	9
57	2x39	3x50	Shared	19.417	30.4644	No	Yes	Yes	Yes	8	9
58	3x51	5x61	Shared	11.4746	20.5749	No	Yes	No	No	8	9
59	6x58	E2.V194	Shared	12.458	19.2791	Yes	Yes	No	No	4	4
60	E2.L195	E2.V194	Shared	15.1172	21.032	No	Yes	No	No	3	4
61	E2.L195	E2.Y198	Shared	23.9677	11.3596	No	Yes	Yes	Yes	3	4
62	3x25	NT.Y29	s1p1_on	7.20987	16.9111	Yes	Yes	Yes	Yes	9	7
63	3x25	E2.L197	s1p1_on	8.4642	45.9153	Yes	Yes	No	No	9	4
64	E2.L197	NT.H28	s1p1_on	0	44.455	No	No	Yes	Yes	4	8
65	3x25	3x29	s1p1_on	7.53098	14.2735	Yes	Yes	Yes	Yes	9	5
66	E2.L195	Lig	s1p1_on	0	41.2715	No	Yes	Yes	Yes	3	0
67	3x25	E2.L195	s1p1_on	0	16.6086	Yes	Yes	No	Yes	9	3
68	E2.L188	NT.H28	s1p1_on	6.35693	10.692	No	No	Yes	Yes	2	8
69	2x57	7x38	s1p1_on	0	26.873	Yes	Yes	No	No	6	5
70	7x38	Lig	s1p1_on	9.04119	27.8991	No	No	Yes	Yes	5	0
71	1x39	2x57	s1p1_on	0	28.8726	No	Yes	Yes	Yes	6	6
72	7x45	7x49	s1p1_on	0	37.1275	No	Yes	No	No	9	9
73	6x48	7x45	s1p1_on	6.01575	37.9563	Yes	Yes	No	Yes	8	9
74	1x50	2x51	s1p1_on	1.38979	16.3093	Yes	Yes	No	No	9	6
75	1x55	1x59	s1p1_on	0	10.1098	No	No	No	No	4	6
76	1x51	1x55	s1p1_on	0	11.3629	No	No	No	No	4	4
77	1x51	2x51	s1p1_on	0	12.6094	No	No	No	No	4	6
78	2x37	2x39	s1p1_on	0	13.4809	No	No	No	Yes	7	8
79	3x46	3x50	s1p1_on	0	38.5878	No	No	Yes	Yes	8	9
80	2x46	3x46	s1p1_on	0	46.1258	No	Yes	No	No	9	8
81	2x46	3x43	s1p1_on	0	44.0966	No	Yes	No	No	9	9
82	4x42	4x46	s1p1_on	0	13.5828	No	Yes	No	No	7	7
83	2x45	4x50	s1p1_on	6.81852	12.8198	No	No	Yes	No	9	9
84	3x38	4x50	s1p1_on	2.74447	14.4873	No	No	Yes	No	7	9
85	3x38	4x53	s1p1_on	0	15.6384	No	No	No	No	7	8
86	3x37	4x53	s1p1_on	2.07215	17.7202	Yes	No	No	No	6	8
87	3x37	Lig	s1p1_on	0	18.766	Yes	No	Yes	Yes	6	0
88	2x39	3x49	s1p1_on	0	17.4604	No	Yes	No	Yes	8	9
89	3x21	3x22	s1p1_on	0	10.692	No	No	No	No	7	3
90	3x22	NT.I24	s1p1_on	1.60052	15.7272	No	No	Yes	No	3	4
91	3x29	E2.Y198	s1p1_on	0	10.123	Yes	Yes	Yes	Yes	5	4
92	3x40	6x48	s1p1_on	0	52.4831	No	No	Yes	Yes	7	8
93	3x40	5x50	s1p1_on	0	51.4997	No	No	No	No	7	8
94	3x44	5x50	s1p1_on	0	43.396	No	Yes	No	No	7	8
95	3x44	3x48	s1p1_on	0	40.2486	No	Yes	No	No	7	6
96	3x51	5x57	s1p1_on	0	37.042	No	Yes	No	No	8	7
97	3x48	5x57	s1p1_on	1.46505	39.1863	No	No	No	No	6	7
98	3x51	5x60	s1p1_on	8.66489	15.6877	No	Yes	No	No	8	5
99	3x54	5x61	s1p1_on	0	19.3909	No	No	No	No	8	9
100	5x64	5x68	s1p1_on	0	12.047	No	No	No	No	6	7
101	5x60	5x64	s1p1_on	7.245	13.2671	No	No	No	No	5	6
102	5x40	6x58	s1p1_on	0	15.4049	No	No	Yes	Yes	6	4
103	5x40	6x55	s1p1_on	6.22648	16.3948	No	No	No	No	6	6
104	6x55	Lig	s1p1_on	0	17.3321	No	No	Yes	Yes	6	0
105	6x58	7x31	s1p1_on	6.96904	23.8538	Yes	Yes	Yes	Yes	4	3
106	5x47	6x52	s1p1_on	6.42717	10.4683	Yes	No	Yes	Yes	7	6
107	5x62	6x33	s1p1_on	0	14.8425	No	Yes	No	No	6	8
108	5x65	6x33	s1p1_on	0	16.9966	No	No	No	No	8	8
109	3x54	5x65	s1p1_on	1.46505	18.1938	No	No	No	No	8	8
110	7x31	E3.C287	s1p1_on	1.40485	11.1458	Yes	Yes	No	No	3	3
111	1x39	7x36	s1p1_on	0	15.8653	No	Yes	No	No	6	3
112	7x33	7x36	s1p1_on	1.34966	11.2872	No	No	No	No	4	3

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
Lig	NT.Y29	Shared	8.79	3.16286	1	1	0	1
Lig	NT.K34	Shared	5.77	3.31714	1	1	0	1
2x60	Lig	Shared	12.17	6.04143	1	1	1	0
3x29	Lig	Shared	14.45	8.36714	1	1	1	0
3x32	Lig	Shared	15.42	4.12143	0	1	1	0
3x33	Lig	Shared	15.77	21.7043	1	1	1	0
3x36	Lig	Shared	3.77	8.20286	1	1	1	0
6x48	Lig	Shared	5.43	5.19571	1	1	1	0
7x35	Lig	s1p1_off	6.32	0	1	0	1	0
7x38	Lig	Shared	17.93	9.01857	1	0	1	0
NT.K34	NT.Y29	Shared	5.97	5.97286	1	1	1	1
E1x50	NT.Y29	s1p1_off	6.24	0	0	0	2	1
E1x501	NT.Y29	Shared	5.96	4.39571	0	0	2	1
3x25	NT.Y29	Shared	10.61	4.68286	1	1	2	1
E2.P196	NT.Y29	Shared	20.86	11.5229	0	0	2	1
2x57	2x60	s1p1_off	9.3	0	0	1	2	1
2x57	3x32	Shared	5.99	4.61714	0	1	2	1
2x60	2x64	s1p1_off	7.45	0	1	1	1	1
2x60	3x29	s1p1_off	5.26	0	1	1	1	1
2x64	3x28	s1p1_off	3.95	0	0	0	1	2
3x28	E1x50	Shared	7.76	4.61857	1	1	2	2
3x25	3x28	Shared	10	6.85714	1	1	2	2
3x25	3x29	Shared	8.72	15.5771	1	1	2	1
3x25	E2.Y198	Shared	6.75	3.44429	1	1	2	2
3x28	3x29	Shared	12.79	5.48571	1	1	2	1
3x33	E2.Y198	s1p1_off	14.44	0	1	1	1	2
3x33	5x39	Shared	10.32	4.71714	1	1	1	2
3x36	5x47	s1p1_off	7.31	0	1	1	1	1
3x36	6x48	Shared	17.08	5.04286	1	1	1	1
3x37	3x41	s1p1_off	5.28	0	0	0	1	2
3x37	4x53	Shared	6.52	3.26	0	0	1	2
3x37	5x47	s1p1_off	5.28	0	0	0	1	1
3x40	5x47	s1p1_off	6.55	0	0	0	2	1
E2.L195	E2.V194	Shared	4.47	4.47	0	1	1	2
E2.L195	E2.Y198	Shared	11.72	6.36428	0	1	1	2
5x40	E2.L195	s1p1_off	5.71	0	0	0	2	1
5x39	E2.Y198	Shared	7.94	4.11286	1	1	2	2
5x39	5x43	Shared	9.41	7.68	1	1	2	2
5x40	6x55	Shared	5.71	4.28	0	0	2	1
5x47	6x52	Shared	6.43	6.73571	0	1	1	2
6x44	6x48	Shared	14.03	8.01714	1	1	2	1
6x44	7x45	Shared	8.46	3.45286	1	1	2	2
6x48	6x52	s1p1_off	8.02	0	1	1	1	2
6x48	7x41	Shared	10.37	1.66714	1	1	1	2
6x48	7x45	Shared	5.65	8.55571	1	1	1	2
6x51	6x55	s1p1_off	5.54	0	0	0	1	1
6x51	7x38	s1p1_off	4.15	0	0	0	1	1
7x33	7x35	s1p1_off	10.47	0	0	0	2	1
7x33	7x36	Shared	7.2	2.20571	0	0	2	2
7x35	7x38	s1p1_off	7.95	0	1	0	1	1
3x37	4x56	s1p1_off	3	0	0	0	1	2
2x64	E1x47	Shared	1.86	2.12286	0	0	1	2
2x56	3x32	s1p1_off	1.61	0	0	0	2	1
2x64	Lig	s1p1_on	0	3.79857	0	0	1	0
3x37	Lig	s1p1_on	0	5.04429	0	0	1	0
5x47	Lig	s1p1_on	0	6.10571	0	1	1	0
6x51	Lig	s1p1_on	0	6.06286	0	0	1	0
6x55	Lig	s1p1_on	0	5.25143	0	0	1	0
2x57	7x38	s1p1_on	0	4.68857	0	1	2	1
2x60	3x28	s1p1_on	0	10.5043	1	1	1	2
2x60	3x32	s1p1_on	0	6.21143	1	1	1	1
E1x50	E1x501	s1p1_on	0	5.17429	0	0	2	2
3x25	E2.L195	s1p1_on	0	3.09286	1	1	2	1
3x29	E2.L195	s1p1_on	0	4.16857	1	1	1	1
3x29	E2.Y198	s1p1_on	0	5.61143	1	1	1	2
3x33	5x43	s1p1_on	0	3.19143	1	1	1	2
3x40	6x48	s1p1_on	0	4.02714	0	0	2	1
5x47	6x48	s1p1_on	0	11.4543	0	1	1	1
E2.L195	Lig	s1p1_on	0	5.89714	0	1	1	0
7x35	7x36	s1p1_on	0	7.21429	1	0	1	2
NT.I25	NT.Y29	s1p1_on	0	2.59286	0	0	2	1
4x56	5x43	s1p1_on	0	2.49143	0	0	2	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	s1p1_off	3V2W-S1P₁-PubChem 51892645
	s1p1_on	7VIE-S1P₁-S1P-Gi1/β1/γ2 7VIF-S1P₁-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P₁-CBP-307-Gi1/β1/γ2 7EVY-S1P₁-Siponimod-Gi1/β1/γ2 7EVZ-S1P₁-Cenerimod-Gi1/β1/γ2 7EW0-S1P₁-Ozanimod-Gi1/β1/γ2 7EW7-S1P₁-SEW2871-Gi1/β1/γ2

Network Difference
Value	s1p1_off	s1p1_on
I_min	3.65	3.08429
Number of Linked Nodes	261	289
Number of Specific Nodes	8 (3.07%)	36 (12.46%)
Number of Shared Nodes	253 (96.93%)	253 (87.54%)
Number of Links	278	315
Number of Specific Links	119 (42.81%)	156 (49.52%)
Number of Shared Links	159 (57.19%)	159 (50.48%)
Number of Hubs	31	40
Number of Specific Hubs	10 (32.26%)	19 (47.50%)
Number of Shared Hubs	21 (67.74%)	21 (52.50%)
Average % Shared Neighbours (Jaccard)	38.00
Average % Shared Neighbours (Otsuka)	46.56
Average % Shared Neighbours (Overlap Coefficient)	55.16
Average % Shared Cliques (k3-6)	54.31
Graphlets Similarity	0.588969

Paths Difference
Value	s1p1_off	s1p1_on
Number Of Nodes in MetaPath	65	70
Specific Nodes in MetaPath	27 (41.54%)	32 (45.71%)
Shared Nodes in MetaPath	253 (96.93%)	253 (96.93%)
Number Of Links MetaPath	61	73
Specific Links in MetaPath	39 (63.93%)	51 (69.86%)
Shared Links in MetaPath	159 (57.19%)	159 (57.19%)
Number of Shortest Paths	38970	66525
Length Of Smallest Path	3	3
Average Path Length	14.465	12.4074
Length of Longest Path	33	29
Minimum Path Strength	1.51	0.204286
Average Path Strength	6.84427	5.00865
Maximum Path Strength	21.075	17.9621
Minimum Path Correlation	0.7	0.7
Average Path Correlation	0.916381	0.929207
Maximum Path Correlation	0.99	0.997143
Minimum % Of Corr. Nodes	4.16667	4
Average % Of Corr. Nodes	47.0132	53.327
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	40.9882	45.7678
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download s1p1_off_on.zip<

You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.

You can also read or download a guide explaining the meaning of all files and numerical data.