psnGPCR

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Orange: nodes, hubs and links specific of s1p1_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of s1p1_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	s1p1_off Int. Strength	s1p1_on Int. Strength	s1p1_off Hub1?	s1p1_on Hub1?	s1p1_off Hub2?	s1p1_on Hub2?	ConSurf1	ConSurf2
1	NT.I24	NT.Y19	s1p1_off	6.04	0	Yes	No	No	No	4	8
2	E2.I185	NT.Y19	s1p1_off	8.46	0	Yes	No	No	No	3	8
3	3x21	NT.V20	s1p1_off	4.76	0	Yes	Yes	No	No	7	5
4	NT.D23	NT.R27	s1p1_off	11.91	0	No	No	No	No	7	3
5	3x22	NT.I24	s1p1_off	5.08	0	No	No	Yes	No	3	4
6	E2.I185	NT.I24	s1p1_off	4.42	0	Yes	No	Yes	No	3	4
7	E2.C191	NT.H28	s1p1_off	4.42	0	No	No	No	Yes	9	8
8	NT.K34	NT.T32	s1p1_off	4.5	0	No	No	No	No	6	8
9	E2.T193	NT.T32	s1p1_off	7.85	0	No	No	No	No	5	8
10	E2.P196	NT.K34	s1p1_off	5.02	0	No	No	No	No	3	6
11	NT.D40	NT.I37	s1p1_off	7	0	No	No	No	No	1	1
12	E1x501	NT.S38	s1p1_off	7.63	0	No	Yes	No	No	5	4
13	1x31	NT.K41	s1p1_off	6.12	0	No	No	No	No	2	6
14	1x49	7x47	s1p1_off	4.91	0	Yes	No	No	No	8	7
15	1x53	7x53	s1p1_off	5.05	0	No	No	Yes	No	9	9
16	6x29	I1x49	s1p1_off	5.4	0	Yes	No	No	No	6	6
17	2x37	2x38	s1p1_off	4.32	0	No	No	No	No	7	7
18	2x39	6x33	s1p1_off	4.24	0	Yes	Yes	No	No	8	8
19	2x43	7x53	s1p1_off	4.84	0	No	No	Yes	No	8	9
20	2x48	4x50	s1p1_off	5.69	0	No	No	Yes	No	5	9
21	2x49	3x39	s1p1_off	4.89	0	No	No	No	No	8	9
22	2x57	2x60	s1p1_off	6.98	0	Yes	Yes	Yes	No	6	5
23	2x60	3x29	s1p1_off	6.57	0	Yes	No	Yes	Yes	5	5
24	2x63	E1x52	s1p1_off	6.92	0	No	No	No	No	4	5
25	3x25	E2.Y198	s1p1_off	4.82	0	Yes	Yes	Yes	Yes	9	4
26	3x26	E2.I185	s1p1_off	5.02	0	Yes	Yes	Yes	No	6	3
27	3x36	5x47	s1p1_off	4.87	0	No	No	Yes	No	6	7
28	3x37	5x47	s1p1_off	5.28	0	No	No	Yes	No	6	7
29	3x40	5x47	s1p1_off	7.87	0	No	No	Yes	No	7	7
30	3x46	6x37	s1p1_off	4.61	0	No	No	No	No	8	8
31	3x49	3x50	s1p1_off	13.96	0	Yes	Yes	Yes	Yes	9	9
32	3x50	3x53	s1p1_off	7.76	0	Yes	Yes	No	No	9	8
33	3x50	6x34	s1p1_off	8.5	0	Yes	Yes	No	No	9	8
34	4x59	4x60	s1p1_off	4.93	0	No	No	No	No	5	5
35	4x59	5x39	s1p1_off	8.21	0	No	No	Yes	Yes	5	7
36	5x36	E2.C184	s1p1_off	4.42	0	Yes	No	No	No	4	5
37	5x52	5x56	s1p1_off	4.28	0	No	No	No	No	4	4
38	5x54	6x41	s1p1_off	8.56	0	No	No	No	No	8	7
39	5x57	5x61	s1p1_off	5.71	0	No	No	No	No	7	9
40	5x58	6x38	s1p1_off	4.84	0	No	Yes	Yes	No	9	5
41	5x60	5x63	s1p1_off	10.54	0	No	No	No	No	5	3
42	5x60	5x64	s1p1_off	10.93	0	No	No	No	No	5	6
43	6x29	8x49	s1p1_off	12.69	0	Yes	No	No	Yes	6	7
44	6x33	8x47	s1p1_off	6.87	0	No	No	No	No	8	8
45	6x33	8x49	s1p1_off	5.3	0	No	No	No	Yes	8	7
46	6x36	8x47	s1p1_off	8.77	0	No	No	No	No	9	8
47	6x39	7x56	s1p1_off	4.56	0	No	No	No	No	6	7
48	6x40	7x49	s1p1_off	5.91	0	No	No	Yes	Yes	8	9
49	6x48	6x52	s1p1_off	7.02	0	Yes	Yes	Yes	Yes	8	6
50	6x51	6x55	s1p1_off	4.15	0	No	No	No	No	6	6
51	6x54	7x34	s1p1_off	4.73	0	No	No	No	No	4	4
52	7x35	Lig	s1p1_off	4.52	0	No	No	Yes	Yes	3	0
53	7x45	7x48	s1p1_off	5.85	0	Yes	Yes	No	No	9	5
54	7x49	7x53	s1p1_off	4.65	0	Yes	Yes	Yes	No	9	9
55	7x53	8x50	s1p1_off	7.18	0	Yes	No	No	No	9	8
56	7x54	8x51	s1p1_off	6.47	0	No	No	No	No	7	8
57	8x59	CT.L330	s1p1_off	5.13	0	No	No	No	No	4	3
58	CT.P329	CT.R328	s1p1_off	4.32	0	No	No	No	No	4	9
59	E2.S186	NT.Y19	s1p1_off	3.82	0	No	No	No	No	1	8
60	5x58	6x37	s1p1_off	3.79	0	No	Yes	No	No	9	8
61	1x39	1x42	s1p1_off	3.77	0	Yes	Yes	No	No	6	6
62	8x50	I1x50	s1p1_off	3.73	0	No	No	Yes	Yes	8	8
63	2x49	4x50	s1p1_off	3.71	0	No	No	Yes	No	8	9
64	4x58	4x61	s1p1_off	3.53	0	No	No	No	No	4	5
65	3x51	5x64	s1p1_off	3.52	0	No	Yes	No	No	8	6
66	3x47	5x54	s1p1_off	3.25	0	No	No	No	No	8	8
67	2x45	4x49	s1p1_off	3.15	0	Yes	No	No	No	9	6
68	5x40	E2.S192	s1p1_off	3.1	0	No	No	No	No	6	4
69	6x40	7x52	s1p1_off	3.07	0	No	No	No	No	8	8
70	1x56	8x57	s1p1_off	3.04	0	No	No	No	No	8	6
71	6x27	6x30	s1p1_off	2.98	0	No	No	No	No	4	7
72	7x39	7x43	s1p1_off	2.98	0	No	No	No	No	5	6
73	5x45	5x49	s1p1_off	2.95	0	No	No	No	No	4	5
74	1x47	1x51	s1p1_off	2.94	0	No	No	No	No	6	4
75	3x48	3x52	s1p1_off	2.94	0	No	No	No	No	6	4
76	4x52	4x56	s1p1_off	2.85	0	No	No	No	No	4	5
77	3x54	5x64	s1p1_off	2.83	0	No	No	No	No	8	6
78	4x38	4x39	s1p1_off	2.72	0	No	No	No	No	7	1
79	7x30	7x37	s1p1_off	2.51	0	No	No	No	No	3	4
80	7x33	NT.K41	s1p1_off	2.48	0	No	No	No	No	4	6
81	7x32	E3.K285	s1p1_off	2.48	0	No	No	No	No	1	2
82	3x34	4x50	s1p1_off	2.45	0	No	No	Yes	No	5	9
83	6x26	6x29	s1p1_off	2.33	0	No	No	Yes	No	4	6
84	1x43	2x54	s1p1_off	1.96	0	No	No	No	No	5	7
85	1x47	2x54	s1p1_off	1.76	0	No	No	No	No	6	7
86	6x24	6x27	s1p1_off	1.71	0	No	No	No	No	2	4
87	6x24	6x28	s1p1_off	1.71	0	No	No	No	Yes	2	5
88	1x36	1x37	s1p1_off	1.62	0	No	No	No	No	5	5
89	2x56	3x32	s1p1_off	1.61	0	No	No	No	No	4	6
90	6x38	6x42	s1p1_off	1.55	0	Yes	No	No	No	5	5
91	1x38	1x42	s1p1_off	1.54	0	No	No	No	No	5	6
92	5x37	E2.S192	s1p1_off	1.53	0	No	No	No	No	3	4
93	1x33	1x37	s1p1_off	1.52	0	No	No	No	No	4	5
94	1x56	1x57	s1p1_off	1.52	0	No	No	No	No	8	7
95	1x60	8x57	s1p1_off	1.52	0	No	No	No	No	6	6
96	3x27	3x31	s1p1_off	1.5	0	No	No	No	No	4	4
97	7x54	7x55	s1p1_off	1.47	0	No	No	No	No	7	6
98	6x28	6x29	s1p1_off	1.44	0	No	Yes	Yes	No	5	6
99	6x41	6x45	s1p1_off	1.43	0	No	No	No	No	7	6
100	6x53	6x57	s1p1_off	1.43	0	No	No	No	No	5	4
101	4x59	4x62	s1p1_off	1.41	0	No	No	No	No	5	4
102	1x29	1x32	s1p1_off	1.37	0	No	No	No	No	3	4
103	6x25	6x26	s1p1_off	1.32	0	No	No	No	No	4	4
104	4x43	4x46	s1p1_off	1.26	0	No	No	No	No	2	7
105	8x51	8x55	s1p1_off	1.25	0	No	No	No	No	8	3
106	2x41	4x46	s1p1_off	1.21	0	No	No	No	No	4	7
107	5x62	6x38	s1p1_off	1.21	0	No	No	Yes	No	6	5
108	NT.D23	NT.N21	Shared	5.39	1.8525	No	No	No	No	7	8
109	NT.I24	NT.N21	Shared	8.5	1.23875	Yes	No	No	No	4	8
110	3x21	NT.Y22	Shared	6.24	2.81	Yes	Yes	No	No	7	5
111	3x25	NT.I25	Shared	5.87	2.7875	Yes	Yes	No	No	9	4
112	NT.L35	NT.V26	Shared	4.47	0.93125	No	Yes	No	No	6	6
113	E2.L188	NT.H28	Shared	6.43	4.50125	No	No	No	Yes	2	8
114	E2.L197	NT.H28	Shared	9	8.035	No	No	No	Yes	4	8
115	NT.K34	NT.Y29	Shared	7.17	6.27	No	No	Yes	Yes	6	7
116	E1x50	NT.Y29	Shared	4.99	4.0575	No	No	Yes	Yes	5	7
117	E1x501	NT.Y29	Shared	6.95	3.84625	No	Yes	Yes	Yes	5	7
118	3x25	NT.Y29	Shared	8.68	5.90625	Yes	Yes	Yes	Yes	9	7
119	E2.P196	NT.Y29	Shared	20.86	12.69	No	No	Yes	Yes	3	7
120	Lig	NT.Y29	Shared	7.99	3.28625	Yes	Yes	Yes	Yes	0	7
121	NT.L35	NT.N30	Shared	6.87	3.77625	No	Yes	No	No	6	9
122	E2.L188	NT.Y31	Shared	16.41	7.03375	No	No	No	No	2	5
123	E3.V284	NT.Y31	Shared	11.36	2.83875	No	No	No	No	1	5
124	E2.P196	NT.T32	Shared	6.99	5.68375	No	No	No	No	3	8
125	E1x501	NT.L35	Shared	5.86	1.90375	No	Yes	No	Yes	5	6
126	1x39	7x39	Shared	10.49	11.1437	Yes	Yes	No	No	6	5
127	1x43	2x58	Shared	5.07	3.38	No	No	No	No	5	6
128	1x45	1x49	Shared	12.83	8.745	No	No	Yes	No	4	8
129	1x46	7x47	Shared	7.05	6.16875	No	No	No	No	7	7
130	1x48	1x52	Shared	4.87	1.675	No	No	No	No	4	7
131	1x49	7x50	Shared	14.15	2.94625	Yes	No	No	No	8	9
132	1x49	7x51	Shared	6.83	5.63625	Yes	No	No	No	8	6
133	1x50	2x50	Shared	5.39	8.75	No	Yes	No	Yes	9	9
134	1x50	2x51	Shared	6.87	4.2925	No	Yes	No	No	9	6
135	1x50	7x50	Shared	4.89	5.50125	No	Yes	No	No	9	9
136	1x52	8x54	Shared	8.57	5.225	No	No	No	Yes	7	7
137	1x57	2x40	Shared	4.84	2.72	No	No	No	Yes	7	9
138	1x60	I1x50	Shared	11.67	13.1313	No	No	Yes	Yes	6	8
139	2x40	I1x50	Shared	28.88	22.695	No	Yes	Yes	Yes	9	8
140	8x53	I1x50	Shared	4.16	3.1175	No	No	Yes	Yes	7	8
141	2x41	I1x51	Shared	5.44	3.95	No	No	No	No	4	7
142	2x37	2x40	Shared	4.12	10.2875	No	No	No	Yes	7	9
143	2x39	2x43	Shared	5.83	2.55375	Yes	Yes	No	No	8	8
144	2x39	3x49	Shared	10.83	6.42875	Yes	Yes	Yes	Yes	8	9
145	2x39	3x50	Shared	11.17	3.41	Yes	Yes	Yes	Yes	8	9
146	2x42	3x45	Shared	8.32	2.77	No	Yes	No	No	8	7
147	2x42	3x49	Shared	4.66	10.785	No	Yes	Yes	Yes	8	9
148	2x45	3x42	Shared	7.45	4.0975	Yes	No	No	No	9	8
149	2x45	4x46	Shared	12.74	8.67375	Yes	No	No	No	9	7
150	2x45	4x50	Shared	6.78	6.78	Yes	No	Yes	No	9	9
151	2x46	3x42	Shared	6.01	6.19375	No	Yes	No	No	9	8
152	2x46	3x43	Shared	4.15	3.805	No	Yes	No	No	9	9
153	2x46	7x49	Shared	4.12	3.94875	No	Yes	Yes	Yes	9	9
154	2x50	7x46	Shared	10.31	7.545	No	Yes	No	No	9	9
155	2x50	7x49	Shared	6.73	5.555	No	Yes	Yes	Yes	9	9
156	2x57	2x61	Shared	10.55	10.55	Yes	Yes	Yes	Yes	6	5
157	2x57	3x32	Shared	5.99	5.83625	Yes	Yes	No	No	6	6
158	2x57	7x42	Shared	17.66	12.3025	Yes	Yes	No	No	6	7
159	2x60	3x28	Shared	7.23	8.88875	Yes	No	Yes	Yes	5	6
160	2x60	Lig	Shared	9.36	7.97375	Yes	No	Yes	Yes	5	0
161	3x28	E1x50	Shared	6.47	5.4975	Yes	Yes	No	No	6	5
162	3x24	E1x52	Shared	9.32	10.3175	No	No	No	No	4	5
163	3x28	E1x52	Shared	4.86	2.4275	Yes	Yes	No	No	6	5
164	3x21	3x24	Shared	15.59	6.555	Yes	Yes	No	No	7	4
165	3x25	3x28	Shared	12	6.5	Yes	Yes	Yes	Yes	9	6
166	3x25	3x29	Shared	7.63	14.5837	Yes	Yes	Yes	Yes	9	5
167	3x25	E2.L197	Shared	19.36	10.6775	Yes	Yes	No	No	9	4
168	3x26	E2.N183	Shared	7.25	7.85375	Yes	Yes	No	Yes	6	5
169	3x26	E2.L197	Shared	9.74	6.09	Yes	Yes	No	No	6	4
170	3x28	3x29	Shared	12.79	6.39875	Yes	Yes	Yes	Yes	6	5
171	3x28	Lig	Shared	5.8	3.20875	Yes	Yes	Yes	Yes	6	0
172	3x29	Lig	Shared	18.97	8.285	Yes	Yes	Yes	Yes	5	0
173	3x32	Lig	Shared	14.45	3.4075	No	No	Yes	Yes	6	0
174	3x33	E2.Y198	Shared	13.41	5.2875	Yes	Yes	Yes	Yes	5	4
175	3x33	5x39	Shared	4.13	5.9325	Yes	Yes	Yes	Yes	5	7
176	3x33	5x43	Shared	4.19	3.49	Yes	Yes	No	No	5	6
177	3x33	Lig	Shared	14.94	22.2262	Yes	Yes	Yes	Yes	5	0
178	3x36	6x48	Shared	15.94	6.12	No	No	Yes	Yes	6	8
179	3x36	Lig	Shared	4.72	8.0675	No	No	Yes	Yes	6	0
180	3x37	4x53	Shared	6.52	4.075	No	No	No	No	6	8
181	3x38	4x50	Shared	7.78	4.05125	No	No	Yes	No	7	9
182	3x40	5x50	Shared	4.47	4.0975	No	No	No	No	7	8
183	3x43	6x44	Shared	8.53	3.9575	No	No	Yes	Yes	9	9
184	3x44	3x48	Shared	7.14	6.60375	No	Yes	No	No	7	6
185	3x44	5x54	Shared	4.28	4.81625	No	Yes	No	No	7	8
186	3x47	5x58	Shared	5.34	4.5025	No	No	No	Yes	8	9
187	3x49	3x53	Shared	4.23	4.05375	Yes	Yes	No	No	9	8
188	3x51	5x61	Shared	6.04	3.77875	No	Yes	No	No	8	9
189	4x38	4x41	Shared	7.23	7.98625	No	No	No	No	7	5
190	4x40	4x44	Shared	7.31	2.8925	No	No	No	No	4	3
191	4x60	E2.Y198	Shared	5.56	9.73875	No	No	Yes	Yes	5	4
192	4x60	5x39	Shared	13.91	13.215	No	No	Yes	Yes	5	7
193	5x36	E2.W182	Shared	5.29	4.365	Yes	No	No	Yes	4	5
194	5x39	E2.W182	Shared	16.4	6.6325	Yes	Yes	No	Yes	7	5
195	5x42	E2.W182	Shared	8.02	3.1325	No	Yes	No	Yes	5	5
196	E2.I185	E2.N183	Shared	11.33	9.735	Yes	No	No	Yes	3	5
197	E2.C184	E2.C191	Shared	7.28	7.28	No	No	No	No	5	9
198	5x36	E2.S190	Shared	9.76	9.065	Yes	No	No	No	4	4
199	6x58	E2.S192	Shared	5.89	3.865	Yes	Yes	No	No	4	4
200	6x58	E2.T193	Shared	7.23	4.155	Yes	Yes	No	No	4	5
201	7x31	E2.T193	Shared	4.42	5.8975	Yes	Yes	No	No	3	5
202	E2.L195	E2.V194	Shared	4.47	4.65625	No	Yes	No	No	3	4
203	6x58	E2.V194	Shared	4.38	5.475	Yes	Yes	No	No	4	4
204	E2.L195	E2.Y198	Shared	10.55	7.62	No	Yes	Yes	Yes	3	4
205	5x36	5x38	Shared	9.55	10.15	Yes	No	No	No	4	4
206	5x39	5x43	Shared	9.41	7.225	Yes	Yes	No	No	7	6
207	5x40	6x55	Shared	7.14	3.56625	No	No	No	No	6	6
208	5x41	6x59	Shared	8.94	4.65625	No	No	No	Yes	5	4
209	5x47	6x52	Shared	4.29	7.50125	Yes	No	Yes	Yes	7	6
210	5x51	6x44	Shared	6.09	3.805	No	No	Yes	Yes	5	9
211	6x34	6x38	Shared	4.28	2.4975	No	No	Yes	No	8	5
212	6x35	6x39	Shared	7.27	1.8175	No	No	No	No	7	6
213	6x36	7x56	Shared	6.28	4.71	No	No	No	No	9	7
214	6x44	6x48	Shared	15.03	6.765	Yes	Yes	Yes	Yes	9	8
215	6x44	7x45	Shared	7.25	4.23	Yes	Yes	Yes	Yes	9	9
216	6x47	7x45	Shared	9.45	6.10125	No	No	Yes	Yes	8	9
217	6x48	7x41	Shared	10.37	3.40375	Yes	Yes	No	No	8	7
218	6x48	7x45	Shared	4.52	8.61625	Yes	Yes	Yes	Yes	8	9
219	6x54	7x37	Shared	10.96	12.4825	No	No	No	No	4	4
220	6x58	7x31	Shared	12.21	6.61625	Yes	Yes	Yes	Yes	4	3
221	6x61	E3.C287	Shared	7.28	7.28	No	No	No	No	4	3
222	E3.K285	E3.V284	Shared	6.07	1.51875	No	No	No	No	2	1
223	7x31	E3.C287	Shared	6.35	4.36375	Yes	Yes	No	No	3	3
224	7x33	7x36	Shared	9.26	4.245	No	No	No	No	4	3
225	7x38	Lig	Shared	19.81	8.86375	No	No	Yes	Yes	5	0
226	7x54	8x54	Shared	5.19	0.9725	No	No	No	Yes	7	7
227	8x47	8x50	Shared	15.43	9.9925	No	No	No	No	8	8
228	8x48	8x51	Shared	6.19	5.41375	No	No	No	No	6	8
229	2x64	Lig	Shared	4.09	5.42875	No	No	Yes	Yes	4	0
230	1x43	2x57	Shared	4.03	4.53875	No	No	Yes	Yes	5	6
231	5x42	5x46	Shared	3.93	3.44125	No	Yes	No	No	5	5
232	1x56	8x54	Shared	3.89	3.89125	No	No	No	Yes	8	7
233	5x44	6x52	Shared	3.89	4.05375	No	No	Yes	Yes	5	6
234	3x41	4x52	Shared	3.77	6.37625	No	No	No	No	5	4
235	2x64	E1x47	Shared	3.71	2.5525	No	No	No	No	4	4
236	2x42	4x42	Shared	3.65	5.78625	No	Yes	No	Yes	8	7
237	3x41	5x50	Shared	3.65	11.9487	No	No	No	No	5	8
238	E3.K285	NT.G33	Shared	3.49	3.2675	No	No	No	No	2	7
239	2x52	4x50	Shared	3.42	2.4225	No	No	Yes	No	6	9
240	2x53	7x46	Shared	3.42	2.1375	No	No	No	No	8	9
241	1x53	2x47	Shared	3.39	2.54375	No	No	No	Yes	9	9
242	6x43	7x48	Shared	3.17	2.58	No	No	No	No	7	5
243	1x54	2x47	Shared	3.15	3.15125	No	No	No	Yes	8	9
244	3x54	5x65	Shared	3.04	2.09	No	No	No	No	8	8
245	1x36	2x61	Shared	3	3.565	No	No	Yes	Yes	5	5
246	E3.K283	E3.T286	Shared	3	4.69	No	No	No	No	1	1
247	3x34	4x54	Shared	2.98	3.16625	No	No	No	No	5	4
248	NT.D18	NT.V20	Shared	2.92	2.0075	No	No	No	No	6	5
249	1x59	8x57	Shared	2.91	1.45375	No	Yes	No	No	6	6
250	6x50	7x37	Shared	2.89	3.06875	No	No	No	No	9	4
251	1x40	2x61	Shared	2.85	3.0325	No	No	Yes	Yes	3	5
252	6x54	7x31	Shared	2.77	2.9425	No	No	Yes	Yes	4	3
253	1x35	1x39	Shared	2.59	3.5675	No	No	Yes	Yes	5	6
254	5x48	6x52	Shared	2.59	3.24125	No	No	Yes	Yes	4	6
255	E2.S189	NT.Y31	Shared	2.54	2.2275	No	No	No	No	4	5
256	3x26	4x61	Shared	2.51	5.1825	Yes	Yes	No	No	6	5
257	1x39	2x61	Shared	2.44	3.6525	Yes	Yes	Yes	Yes	6	5
258	4x57	4x58	Shared	2.11	2.11	No	No	No	No	6	4
259	2x44	2x47	Shared	1.95	1.95	No	No	No	Yes	5	9
260	6x49	6x50	Shared	1.87	1.87	No	No	No	No	6	9
261	2x53	3x35	Shared	1.79	1.79	No	No	No	No	8	6
262	2x56	3x31	Shared	1.71	2.1375	No	No	No	No	4	4
263	E2.A187	E2.S190	Shared	1.71	1.49625	No	No	No	No	4	4
264	4x63	E2.N183	Shared	1.7	1.90875	No	No	No	Yes	5	5
265	6x61	E3.T286	Shared	1.69	2.535	No	No	No	No	4	1
266	3x21	3x23	Shared	1.68	2.1	Yes	Yes	No	No	7	2
267	1x40	1x44	Shared	1.64	1.025	No	No	No	No	3	5
268	6x50	7x40	Shared	1.64	3.69375	No	No	No	No	9	7
269	3x47	5x57	Shared	1.58	2.365	No	No	No	No	8	7
270	1x31	1x32	Shared	1.55	0.3875	No	No	No	No	2	4
271	1x47	2x55	Shared	1.54	2.49625	No	No	No	No	6	5
272	4x51	4x55	Shared	1.54	1.5375	No	No	No	No	4	4
273	5x40	6x59	Shared	1.54	2.305	No	No	No	Yes	6	4
274	5x55	6x41	Shared	1.49	5.40125	No	No	No	No	4	7
275	3x30	E2.Y198	Shared	1.45	1.0875	No	No	Yes	Yes	6	4
276	5x51	6x45	Shared	1.43	4.28125	No	No	No	No	5	6
277	1x58	1x59	Shared	1.16	4.06	No	No	No	Yes	3	6
278	NT.H28	NT.I24	s1p1_on	0	3.31375	No	Yes	Yes	No	8	4
279	E2.C184	NT.H28	s1p1_on	0	3.68625	No	No	No	Yes	5	8
280	1x38	1x39	s1p1_on	0	3.6025	No	No	Yes	Yes	5	6
281	1x39	2x57	s1p1_on	0	3.48125	Yes	Yes	Yes	Yes	6	6
282	1x47	2x51	s1p1_on	0	4.28	No	No	No	No	6	6
283	1x51	2x51	s1p1_on	0	3.38875	No	No	No	No	4	6
284	1x60	I1x49	s1p1_on	0	3.75125	No	No	No	No	6	6
285	8x49	I1x49	s1p1_on	0	5.0625	No	Yes	No	No	7	6
286	2x40	8x47	s1p1_on	0	4.94	No	Yes	No	No	9	8
287	2x40	8x49	s1p1_on	0	4.06875	No	Yes	No	Yes	9	7
288	2x40	8x50	s1p1_on	0	5.985	No	Yes	No	No	9	8
289	2x41	4x42	s1p1_on	0	4.9825	No	No	No	Yes	4	7
290	2x42	4x45	s1p1_on	0	4.87125	No	Yes	No	No	8	6
291	2x46	2x50	s1p1_on	0	5.2575	No	Yes	No	Yes	9	9
292	2x46	3x46	s1p1_on	0	3.565	No	Yes	No	No	9	8
293	2x57	7x38	s1p1_on	0	6.5925	Yes	Yes	No	No	6	5
294	2x57	7x39	s1p1_on	0	4.4175	Yes	Yes	No	No	6	5
295	2x60	3x32	s1p1_on	0	5.61125	Yes	No	No	No	5	6
296	2x63	3x28	s1p1_on	0	3.49	No	No	Yes	Yes	4	6
297	E1x50	E1x501	s1p1_on	0	3.435	No	No	No	Yes	5	5
298	3x21	3x22	s1p1_on	0	3.9375	Yes	Yes	No	No	7	3
299	3x25	3x26	s1p1_on	0	3.7575	Yes	Yes	Yes	Yes	9	6
300	3x29	E2.L195	s1p1_on	0	5.63625	Yes	Yes	No	Yes	5	3
301	3x29	E2.Y198	s1p1_on	0	6.0325	Yes	Yes	Yes	Yes	5	4
302	3x37	Lig	s1p1_on	0	6.07125	No	No	Yes	Yes	6	0
303	3x38	4x53	s1p1_on	0	3.20625	No	No	No	No	7	8
304	3x40	6x48	s1p1_on	0	4.1375	No	No	Yes	Yes	7	8
305	3x41	4x49	s1p1_on	0	3.4575	No	No	No	No	5	6
306	3x43	7x49	s1p1_on	0	3.77625	No	No	Yes	Yes	9	9
307	3x46	3x50	s1p1_on	0	4.6975	No	No	Yes	Yes	8	9
308	3x46	7x53	s1p1_on	0	5.1375	No	No	Yes	No	8	9
309	3x49	4x41	s1p1_on	0	4.3625	Yes	Yes	No	No	9	5
310	3x50	5x58	s1p1_on	0	7.0725	Yes	Yes	No	Yes	9	9
311	3x50	7x53	s1p1_on	0	5.78625	Yes	Yes	Yes	No	9	9
312	3x51	3x55	s1p1_on	0	4.25125	No	Yes	No	No	8	6
313	3x51	5x57	s1p1_on	0	5.27625	No	Yes	No	No	8	7
314	3x51	5x60	s1p1_on	0	7.845	No	Yes	No	No	8	5
315	3x52	4x41	s1p1_on	0	5.95125	No	No	No	No	4	5
316	3x56	I2x51	s1p1_on	0	4.67	No	No	No	No	6	7
317	5x68	I2x50	s1p1_on	0	9.15	No	No	No	No	7	8
318	4x42	4x46	s1p1_on	0	3.38875	No	Yes	No	No	7	7
319	4x59	E2.W182	s1p1_on	0	4.2725	No	No	No	Yes	5	5
320	E2.L195	Lig	s1p1_on	0	6.24125	No	Yes	Yes	Yes	3	0
321	5x39	E2.Y198	s1p1_on	0	5.0875	Yes	Yes	Yes	Yes	7	4
322	5x47	6x48	s1p1_on	0	12.1525	Yes	No	Yes	Yes	7	8
323	5x47	Lig	s1p1_on	0	5.53125	Yes	No	Yes	Yes	7	0
324	5x56	5x60	s1p1_on	0	3.76	No	No	No	No	4	5
325	5x58	6x41	s1p1_on	0	3.66375	No	Yes	No	No	9	7
326	5x62	5x66	s1p1_on	0	7.20125	No	No	No	Yes	6	5
327	5x62	6x33	s1p1_on	0	4.1025	No	No	No	No	6	8
328	5x62	6x34	s1p1_on	0	13.4788	No	No	No	No	6	8
329	5x64	5x68	s1p1_on	0	5.92125	No	No	No	No	6	7
330	5x65	6x33	s1p1_on	0	3.91125	No	No	No	No	8	8
331	5x66	5x70	s1p1_on	0	5.8625	No	Yes	No	No	5	0
332	5x72	5x74	s1p1_on	0	3.19625	No	No	No	No	0	0
333	6x43	7x52	s1p1_on	0	4.61	No	No	No	No	7	8
334	6x48	Lig	s1p1_on	0	4.40125	Yes	Yes	Yes	Yes	8	0
335	6x51	Lig	s1p1_on	0	4.6975	No	No	Yes	Yes	6	0
336	6x52	6x56	s1p1_on	0	6.2425	Yes	Yes	No	No	6	6
337	6x55	Lig	s1p1_on	0	4.555	No	No	Yes	Yes	6	0
338	7x35	7x36	s1p1_on	0	4.6275	No	No	No	No	3	3
339	7x45	7x49	s1p1_on	0	8.34375	Yes	Yes	Yes	Yes	9	9
340	7x54	8x50	s1p1_on	0	7.90375	No	No	No	No	7	8
341	8x49	I1x50	s1p1_on	0	3.49875	No	Yes	Yes	Yes	7	8
342	2x38	I2x56	s1p1_on	0	3.1175	No	No	No	No	7	7
343	2x49	3x42	s1p1_on	0	3.05625	No	No	No	No	8	8
344	6x57	6x61	s1p1_on	0	2.97625	No	No	No	No	4	4
345	5x37	6x59	s1p1_on	0	2.8475	No	No	No	Yes	3	4
346	1x55	1x59	s1p1_on	0	2.82	No	No	No	Yes	4	6
347	I2x51	I2x54	s1p1_on	0	2.7975	No	No	No	Yes	7	4
348	E1x501	NT.N36	s1p1_on	0	2.7625	No	Yes	No	No	5	4
349	3x53	I2x54	s1p1_on	0	2.7425	No	No	No	Yes	8	4
350	4x42	4x43	s1p1_on	0	2.74	No	Yes	No	No	7	2
351	I3.F237	I3.R238	s1p1_on	0	2.6725	No	No	No	No	0	0
352	2x38	4x42	s1p1_on	0	2.6675	No	No	No	Yes	7	7
353	E1x49	E1x51	s1p1_on	0	2.62625	No	No	No	No	4	1
354	4x56	5x42	s1p1_on	0	2.58875	No	No	No	Yes	5	5
355	2x50	3x39	s1p1_on	0	2.57625	No	Yes	No	No	9	9
356	6x39	7x52	s1p1_on	0	2.575	No	No	No	No	6	8
357	7x52	7x53	s1p1_on	0	2.57	No	No	Yes	No	8	9
358	4x39	4x43	s1p1_on	0	2.56625	No	No	No	No	1	2
359	3x54	5x61	s1p1_on	0	2.5525	No	No	No	No	8	9
360	NT.H28	NT.R27	s1p1_on	0	2.53875	No	Yes	No	No	8	3
361	8x48	8x49	s1p1_on	0	2.53125	No	No	No	Yes	6	7
362	2x37	2x39	s1p1_on	0	2.48	No	No	Yes	Yes	7	8
363	5x66	6x30	s1p1_on	0	2.47	No	Yes	No	No	5	7
364	3x44	5x50	s1p1_on	0	2.42	No	Yes	No	No	7	8
365	7x32	NT.K34	s1p1_on	0	2.325	No	No	No	No	1	6
366	1x46	1x50	s1p1_on	0	2.30125	No	No	No	Yes	7	9
367	I1x48	I1x51	s1p1_on	0	2.2925	No	No	No	No	6	7
368	3x55	5x64	s1p1_on	0	2.24625	No	No	No	No	6	6
369	1x50	2x47	s1p1_on	0	2.14875	No	Yes	No	Yes	9	9
370	I2x52	I2x53	s1p1_on	0	2.09	No	No	No	No	4	7
371	1x59	1x60	s1p1_on	0	2.065	No	Yes	No	No	6	6
372	3x44	5x53	s1p1_on	0	2.0625	No	Yes	No	No	7	6
373	4x58	4x60	s1p1_on	0	2.03	No	No	No	No	4	5
374	3x34	4x53	s1p1_on	0	2.02	No	No	No	No	5	8
375	7x51	7x55	s1p1_on	0	1.96	No	No	No	No	6	6
376	5x67	5x71	s1p1_on	0	1.94125	No	No	No	No	5	0
377	7x34	E2.V194	s1p1_on	0	1.91125	No	No	No	No	4	4
378	5x58	6x40	s1p1_on	0	1.8925	No	Yes	No	No	9	8
379	5x73	I3.K239	s1p1_on	0	1.8775	No	No	No	No	0	0
380	6x33	6x37	s1p1_on	0	1.8625	No	No	No	No	8	8
381	6x37	6x41	s1p1_on	0	1.8625	No	No	No	No	8	7
382	1x42	1x46	s1p1_on	0	1.8375	No	No	No	No	6	7
383	4x61	4x62	s1p1_on	0	1.825	No	No	No	No	5	4
384	2x53	2x54	s1p1_on	0	1.70625	No	No	No	No	8	7
385	2x57	7x35	s1p1_on	0	1.6825	Yes	Yes	No	No	6	3
386	4x38	4x40	s1p1_on	0	1.6625	No	No	No	No	7	4
387	7x29	7x32	s1p1_on	0	1.64125	No	No	No	No	3	1
388	1x33	1x35	s1p1_on	0	1.50125	No	No	No	No	4	5
389	5x55	5x59	s1p1_on	0	1.49625	No	No	No	No	4	3
390	6x27	6x28	s1p1_on	0	1.4375	No	No	No	Yes	4	5
391	1x40	2x62	s1p1_on	0	1.42875	No	No	No	No	3	6
392	8x54	8x55	s1p1_on	0	1.41375	No	Yes	No	No	7	3
393	5x71	5x72	s1p1_on	0	1.36625	No	No	No	No	0	0
394	2x56	3x35	s1p1_on	0	1.3425	No	No	No	No	4	6
395	5x68	5x71	s1p1_on	0	1.3325	No	No	No	No	7	0
396	3x24	3x27	s1p1_on	0	1.33125	No	No	No	No	4	4
397	I2x54	I2x55	s1p1_on	0	1.27375	No	Yes	No	No	4	4
398	6x52	6x53	s1p1_on	0	1.25625	Yes	Yes	No	No	6	5
399	7x30	7x33	s1p1_on	0	1.25375	No	No	No	No	3	4
400	1x42	7x43	s1p1_on	0	1.24875	No	No	No	No	6	6
401	2x48	2x52	s1p1_on	0	1.21	No	No	No	No	5	6
402	6x36	6x40	s1p1_on	0	1.1925	No	No	No	No	9	8
403	1x32	1x36	s1p1_on	0	1.16125	No	No	No	No	4	5
404	5x63	5x66	s1p1_on	0	1.15375	No	No	No	Yes	3	5
405	6x59	6x60	s1p1_on	0	1.15	No	Yes	No	No	4	4
406	I3.K239	I3.R238	s1p1_on	0	1.0825	No	No	No	No	0	0
407	E2.N183	NT.Y19	s1p1_on	0	1.0175	No	Yes	No	No	5	8
408	5x69	5x73	s1p1_on	0	1	No	No	No	No	0	0
409	4x43	4x47	s1p1_on	0	0.99125	No	No	No	No	2	4
410	6x28	6x30	s1p1_on	0	0.89875	No	Yes	No	No	5	7
411	5x42	5x45	s1p1_on	0	0.81125	No	Yes	No	No	5	4
412	5x48	5x49	s1p1_on	0	0.73625	No	No	No	No	4	5
413	8x52	8x56	s1p1_on	0	0.66625	No	No	No	No	5	4
414	I2x53	I2x54	s1p1_on	0	0.6375	No	No	No	Yes	7	4
415	5x65	5x69	s1p1_on	0	0.6075	No	No	No	No	8	0
416	6x42	6x43	s1p1_on	0	0.6075	No	No	No	No	5	7
417	5x69	6x29	s1p1_on	0	0.57375	No	No	Yes	No	0	6
418	1x37	1x41	s1p1_on	0	0.55875	No	No	No	No	5	4
419	1x38	1x41	s1p1_on	0	0.55875	No	No	No	No	5	4
420	1x34	1x35	s1p1_on	0	0.5525	No	No	No	No	4	5
421	NT.I37	NT.L35	s1p1_on	0	0.535	No	No	No	Yes	1	6
422	NT.D18	NT.N21	s1p1_on	0	0.505	No	No	No	No	6	8
423	6x28	6x31	s1p1_on	0	0.4975	No	Yes	No	No	5	5
424	8x55	8x56	s1p1_on	0	0.47	No	No	No	No	3	4
425	E1x501	E1x51	s1p1_on	0	0.4475	No	Yes	No	No	5	1
426	E2.A187	E2.S186	s1p1_on	0	0.4275	No	No	No	No	4	1
427	4x48	4x52	s1p1_on	0	0.405	No	No	No	No	3	4
428	E1x48	E1x51	s1p1_on	0	0.4025	No	No	No	No	4	1
429	4x51	4x52	s1p1_on	0	0.385	No	No	No	No	4	4
430	5x48	5x52	s1p1_on	0	0.3675	No	No	No	No	4	4
431	NT.D18	NT.S17	s1p1_on	0	0.3675	No	No	No	No	6	7
432	2x58	2x59	s1p1_on	0	0.21	No	No	No	No	6	7
433	6x28	6x32	s1p1_on	0	0.18875	No	Yes	No	No	5	7
434	I3.I241	I3.K239	s1p1_on	0	0.18125	No	No	No	No	0	0

Orange: nodes, hubs and links specific of s1p1_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of s1p1_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	s1p1_off Avg Int. Strength	s1p1_on Avg Int. Strength	s1p1_off Num Of Links	s1p1_on Num Of Links	ConSurf
1	NT.I24	s1p1_off	6.01	2.27625	4	2	4
2	1x49	s1p1_off	9.68	5.77583	4	3	8
3	2x45	s1p1_off	7.53	6.51708	4	3	9
4	2x60	s1p1_off	7.535	7.49125	4	3	5
5	4x50	s1p1_off	4.97167	4.41792	6	3	9
6	E2.I185	s1p1_off	7.3075	9.735	4	1	3
7	5x36	s1p1_off	7.255	7.86	4	3	4
8	5x47	s1p1_off	5.5775	8.395	4	3	7
9	6x29	s1p1_off	5.465	0.57375	4	1	6
10	6x38	s1p1_off	2.97	2.4975	4	1	5
11	7x53	s1p1_off	5.43	4.49792	4	3	9
12	NT.Y29	Shared	9.44	6.00938	6	6	7
13	1x39	Shared	4.8225	5.0895	4	5	6
14	I1x50	Shared	12.11	10.6106	4	4	8
15	2x39	Shared	8.0175	3.71812	4	4	8
16	2x57	Shared	9.042	6.17516	5	8	6
17	2x61	Shared	4.71	5.2	4	4	5
18	3x21	Shared	7.0675	3.85063	4	4	7
19	3x25	Shared	9.72667	7.36875	6	6	9
20	3x26	Shared	6.13	5.72094	4	4	6
21	3x28	Shared	8.19167	5.20161	6	7	6
22	3x29	Shared	11.49	8.18725	4	5	5
23	3x33	Shared	9.1675	9.23406	4	4	5
24	3x49	Shared	8.42	6.4075	4	4	9
25	3x50	Shared	10.3475	5.24156	4	4	9
26	E2.Y198	Shared	7.158	5.80896	5	6	4
27	5x39	Shared	10.412	7.6185	5	5	7
28	6x44	Shared	9.225	4.68937	4	4	9
29	6x48	Shared	10.576	6.51375	5	7	8
30	6x52	Shared	4.4475	4.459	4	5	6
31	6x58	Shared	7.4275	5.02781	4	4	4
32	7x31	Shared	6.4375	4.955	4	4	3
33	7x45	Shared	6.7675	6.82281	4	4	9
34	7x49	Shared	5.3525	5.40594	4	4	9
35	Lig	Shared	10.465	6.81633	10	15	0
36	NT.H28	s1p1_on	6.61667	4.415	3	5	8
37	NT.L35	s1p1_on	5.73333	1.78656	3	4	6
38	1x50	s1p1_on	5.71667	4.59875	3	5	9
39	1x59	s1p1_on	2.035	2.59969	2	4	6
40	2x40	s1p1_on	12.6133	8.44937	3	6	9
41	2x42	s1p1_on	5.54333	6.05312	3	4	8
42	2x46	s1p1_on	4.76	4.554	3	5	9
43	2x47	s1p1_on	2.83	2.44844	3	4	9
44	2x50	s1p1_on	7.47667	5.93675	3	5	9
45	E1x501	s1p1_on	6.81333	2.479	3	5	5
46	3x44	s1p1_on	5.71	3.97563	2	4	7
47	3x51	s1p1_on	4.78	5.28781	2	4	8
48	I2x54	s1p1_on	0	1.86281	0	4	4
49	4x42	s1p1_on	3.65	3.913	1	5	7
50	E2.W182	s1p1_on	9.90333	4.60063	3	4	5
51	E2.N183	s1p1_on	6.76	5.12875	3	4	5
52	E2.L195	s1p1_on	7.51	6.03844	2	4	3
53	5x42	s1p1_on	5.975	2.49344	2	4	5
54	5x58	s1p1_on	4.65667	4.28281	3	4	9
55	5x66	s1p1_on	0	4.17188	0	4	5
56	6x28	s1p1_on	1.575	0.755625	2	4	5
57	6x59	s1p1_on	5.24	2.73969	2	4	4
58	8x49	s1p1_on	8.995	3.79031	2	4	7
59	8x54	s1p1_on	5.88333	2.87563	3	4	7

Orange: nodes, hubs and links specific of s1p1_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of s1p1_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	s1p1_off Recurrence	s1p1_on Recurrence	s1p1_off Hub1?	s1p1_on Hub1?	s1p1_off Hub2?	s1p1_on Hub2?	ConSurf1	ConSurf2
1	3x26	E2.L197	s1p1_off	26.9525	0.21944	Yes	Yes	No	No	6	4
2	3x26	E2.I185	s1p1_off	15.5007	0	Yes	Yes	Yes	No	6	3
3	NT.K34	NT.Y29	s1p1_off	17.461	2.72186	No	No	Yes	Yes	6	7
4	E2.P196	NT.Y29	s1p1_off	17.461	1.81793	No	No	Yes	Yes	3	7
5	NT.K34	NT.T32	s1p1_off	16.6625	0	No	No	No	No	6	8
6	E2.P196	NT.T32	s1p1_off	16.6625	0.909969	No	No	No	No	3	8
7	E2.T193	NT.T32	s1p1_off	31.659	0	No	No	No	No	5	8
8	1x39	2x61	s1p1_off	10.744	0.102674	Yes	Yes	Yes	Yes	6	5
9	2x57	2x60	s1p1_off	20.2386	0	Yes	Yes	Yes	No	6	5
10	1x43	2x57	s1p1_off	10.744	5.5786	No	No	Yes	Yes	5	6
11	3x36	6x48	s1p1_off	95.5001	0.559671	No	No	Yes	Yes	6	8
12	3x36	Lig	s1p1_off	100	0.491222	No	No	Yes	Yes	6	0
13	1x56	8x54	s1p1_off	18.5602	1.27436	No	No	No	Yes	8	7
14	1x56	8x57	s1p1_off	10.4653	0	No	No	No	No	8	6
15	1x60	8x57	s1p1_off	13.7001	0	No	No	No	No	6	6
16	1x60	I1x50	s1p1_off	14.8212	6.1121	No	No	Yes	Yes	6	8
17	8x50	I1x50	s1p1_off	31.6121	0	No	No	Yes	Yes	8	8
18	7x53	8x50	s1p1_off	42.1463	0	Yes	No	No	No	9	8
19	7x49	7x53	s1p1_off	61.3891	0	Yes	Yes	Yes	No	9	9
20	1x56	1x57	s1p1_off	10.4653	0	No	No	No	No	8	7
21	1x57	2x40	s1p1_off	11.5801	1.27436	No	No	No	Yes	7	9
22	2x40	I1x50	s1p1_off	14.8588	8.35481	No	Yes	Yes	Yes	9	8
23	6x29	8x49	s1p1_off	15.8358	0	Yes	No	No	Yes	6	7
24	6x33	8x49	s1p1_off	17.7272	0	No	No	No	Yes	8	7
25	2x39	6x33	s1p1_off	12.6542	0	Yes	Yes	No	No	8	8
26	2x39	2x43	s1p1_off	20.4108	1.27436	Yes	Yes	No	No	8	8
27	2x43	7x53	s1p1_off	21.2908	0	No	No	Yes	No	8	9
28	6x33	8x47	s1p1_off	12.8139	0	No	No	No	No	8	8
29	8x47	8x50	s1p1_off	17.1635	0.0161057	No	No	No	No	8	8
30	2x45	3x42	s1p1_off	15.5477	4.21767	Yes	No	No	No	9	8
31	2x46	3x42	s1p1_off	16.6249	6.50064	No	Yes	No	No	9	8
32	3x36	5x47	s1p1_off	10.8818	0	No	No	Yes	No	6	7
33	5x54	6x41	s1p1_off	17.652	0	No	No	No	No	8	7
34	6x41	6x45	s1p1_off	19.3869	0	No	No	No	No	7	6
35	5x51	6x45	s1p1_off	20.3294	0.889837	No	No	No	No	5	6
36	5x51	6x44	s1p1_off	21.3346	1.77766	No	No	Yes	Yes	5	9
37	3x47	5x54	s1p1_off	15.0279	0	No	No	No	No	8	8
38	E2.L195	E2.Y198	s1p1_off	11.7899	3.93179	No	Yes	Yes	Yes	3	4
39	6x58	E2.S192	s1p1_off	15.9548	0.863666	Yes	Yes	No	No	4	4
40	7x31	E2.T193	s1p1_off	19.6875	0.0201321	Yes	Yes	No	No	3	5
41	5x40	E2.S192	s1p1_off	11.4267	0	No	No	No	No	6	4
42	6x54	7x31	s1p1_off	13.1709	4.28612	No	No	Yes	Yes	4	3
43	7x54	8x54	s1p1_off	11.6459	8.63263	No	No	No	Yes	7	7
44	2x60	Lig	s1p1_off	15.2001	0.587856	Yes	No	Yes	Yes	5	0
45	6x58	E2.T193	s1p1_off	10.409	0.84152	Yes	Yes	No	No	4	5
46	3x25	3x28	Shared	17.8806	18.59	Yes	Yes	Yes	Yes	9	6
47	3x25	E2.L197	Shared	44.8394	35.7284	Yes	Yes	No	No	9	4
48	3x25	NT.Y29	Shared	16.985	17.6518	Yes	Yes	Yes	Yes	9	7
49	E2.L188	NT.H28	Shared	13.5216	13.2852	No	No	No	Yes	2	8
50	E2.L197	NT.H28	Shared	17.8243	33.8601	No	No	No	Yes	4	8
51	Lig	NT.Y29	Shared	46.6306	28.4969	Yes	Yes	Yes	Yes	0	7
52	3x28	Lig	Shared	18.6729	23.7961	Yes	Yes	Yes	Yes	6	0
53	3x29	Lig	Shared	13.1991	20.5267	Yes	Yes	Yes	Yes	5	0
54	3x25	3x29	Shared	15.4506	18.6866	Yes	Yes	Yes	Yes	9	5
55	E2.L188	NT.Y31	Shared	11.6083	11.0807	No	No	No	No	2	5
56	2x57	2x61	Shared	21.2657	12.2403	Yes	Yes	Yes	Yes	6	5
57	2x50	7x49	Shared	13.7878	13.1885	No	Yes	Yes	Yes	9	9
58	2x46	7x49	Shared	70.6175	45.4401	No	Yes	Yes	Yes	9	9
59	2x46	3x43	Shared	79.4858	45.9192	No	Yes	No	No	9	9
60	3x43	6x44	Shared	80.0056	46.2937	No	No	Yes	Yes	9	9
61	6x44	6x48	Shared	94.2788	46.7366	Yes	Yes	Yes	Yes	9	8
62	3x32	Lig	Shared	18.4975	21.0018	No	No	Yes	Yes	6	0
63	3x47	5x58	Shared	10.0113	17.5189	No	No	No	Yes	8	9
64	6x58	E2.V194	Shared	10.0833	11.7511	Yes	Yes	No	No	4	4
65	E2.L195	E2.V194	Shared	10.9789	13.2268	No	Yes	No	No	3	4
66	3x33	Lig	Shared	17.3483	15.7151	Yes	Yes	Yes	Yes	5	0
67	2x57	3x32	Shared	14.7273	21.8876	Yes	Yes	No	No	6	6
68	1x39	2x57	s1p1_on	0	12.2182	Yes	Yes	Yes	Yes	6	6
69	2x57	7x38	s1p1_on	0	20.3294	Yes	Yes	No	No	6	5
70	7x38	Lig	s1p1_on	1.13985	21.1528	No	No	Yes	Yes	5	0
71	1x50	2x50	s1p1_on	9.29104	13.877	No	Yes	No	Yes	9	9
72	7x45	7x49	s1p1_on	0	58.6367	Yes	Yes	Yes	Yes	9	9
73	6x48	7x45	s1p1_on	3.01559	58.8762	Yes	Yes	Yes	Yes	8	9
74	6x48	Lig	s1p1_on	0	100	Yes	Yes	Yes	Yes	8	0
75	2x40	8x50	s1p1_on	0	10.8894	No	Yes	No	No	9	8
76	2x37	2x40	s1p1_on	2.40183	27.0494	No	No	No	Yes	7	9
77	2x37	2x39	s1p1_on	0	28.2332	No	No	Yes	Yes	7	8
78	2x39	3x50	s1p1_on	9.02486	44.8623	Yes	Yes	Yes	Yes	8	9
79	3x46	3x50	s1p1_on	0	85.5532	No	No	Yes	Yes	8	9
80	2x46	3x46	s1p1_on	0	93.6222	No	Yes	No	No	9	8
81	3x37	Lig	s1p1_on	0	10.7425	No	No	Yes	Yes	6	0
82	2x39	3x49	s1p1_on	5.46753	17.9598	Yes	Yes	Yes	Yes	8	9
83	3x40	6x48	s1p1_on	0	11.8598	No	No	Yes	Yes	7	8
84	3x40	5x50	s1p1_on	6.14705	10.8935	No	No	No	No	7	8
85	3x50	5x58	s1p1_on	0	49.8591	Yes	Yes	No	Yes	9	9
86	3x51	5x57	s1p1_on	0	15.1796	No	Yes	No	No	8	7
87	3x47	5x57	s1p1_on	9.89228	16.3311	No	No	No	No	8	7
88	5x58	6x41	s1p1_on	0	28.5271	No	Yes	No	No	9	7
89	5x62	6x33	s1p1_on	0	13.4402	No	No	No	No	6	8
90	6x33	6x37	s1p1_on	0	23.9048	No	No	No	No	8	8
91	6x37	6x41	s1p1_on	0	25.0544	No	No	No	No	8	7
92	5x65	6x33	s1p1_on	0	10.2613	No	No	No	No	8	8
93	NT.H28	NT.I24	s1p1_on	0	12.0289	No	Yes	Yes	No	8	4
94	3x25	3x26	s1p1_on	0	14.6058	Yes	Yes	Yes	Yes	9	6
95	E2.L195	Lig	s1p1_on	0	15.2943	No	Yes	Yes	Yes	3	0
96	3x33	5x39	s1p1_on	9.0687	10.5713	Yes	Yes	Yes	Yes	5	7

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
NT.K34	NT.Y29	Shared	7.17	6.27	1	0	2	1
E1x50	NT.Y29	Shared	4.99	4.0575	0	1	2	1
E1x501	NT.Y29	Shared	6.95	3.84625	0	1	2	1
3x25	NT.Y29	Shared	8.68	5.90625	1	1	2	1
E2.P196	NT.Y29	Shared	20.86	12.69	1	0	2	1
Lig	NT.Y29	Shared	7.99	3.28625	1	1	0	1
E2.P196	NT.K34	s1p1_off	5.02	0	1	0	2	2
2x57	2x60	s1p1_off	6.98	0	0	1	2	1
2x57	3x32	Shared	5.99	5.83625	0	1	2	1
2x60	3x28	Shared	7.23	8.88875	1	1	1	1
2x60	3x29	s1p1_off	6.57	0	1	1	1	1
2x60	Lig	Shared	9.36	7.97375	1	1	1	0
2x63	E1x52	s1p1_off	6.92	0	0	0	2	2
3x28	E1x50	Shared	6.47	5.4975	1	1	1	2
3x28	E1x52	Shared	4.86	2.4275	1	1	1	2
3x25	3x28	Shared	12	6.5	1	1	2	1
3x25	3x29	Shared	7.63	14.5837	1	1	2	1
3x25	E2.Y198	s1p1_off	4.82	0	1	1	2	2
3x28	3x29	Shared	12.79	6.39875	1	1	1	1
3x28	Lig	Shared	5.8	3.20875	1	1	1	0
3x29	Lig	Shared	18.97	8.285	1	1	1	0
3x32	Lig	Shared	14.45	3.4075	0	1	1	0
3x33	E2.Y198	Shared	13.41	5.2875	1	1	1	2
3x33	5x39	Shared	4.13	5.9325	1	1	1	2
3x33	5x43	Shared	4.19	3.49	1	1	1	2
3x33	Lig	Shared	14.94	22.2262	1	1	1	0
3x36	5x47	s1p1_off	4.87	0	0	1	1	1
3x36	6x48	Shared	15.94	6.12	0	1	1	1
3x36	Lig	Shared	4.72	8.0675	0	1	1	0
3x37	4x53	Shared	6.52	4.075	0	0	1	2
3x37	5x47	s1p1_off	5.28	0	0	0	1	1
3x40	5x47	s1p1_off	7.87	0	0	0	2	1
E2.L195	E2.V194	Shared	4.47	4.65625	0	1	1	2
E2.L195	E2.Y198	Shared	10.55	7.62	0	1	1	2
5x39	5x43	Shared	9.41	7.225	1	1	2	2
5x40	6x55	Shared	7.14	3.56625	0	0	2	1
5x47	6x52	Shared	4.29	7.50125	0	1	1	2
6x44	6x48	Shared	15.03	6.765	4	1	2	1
6x44	7x45	Shared	7.25	4.23	4	1	2	2
6x48	6x52	s1p1_off	7.02	0	4	1	1	2
6x48	7x41	Shared	10.37	3.40375	4	1	1	2
6x48	7x45	Shared	4.52	8.61625	4	1	1	2
6x51	6x55	s1p1_off	4.15	0	0	0	1	1
7x35	Lig	s1p1_off	4.52	0	0	0	1	0
7x38	Lig	Shared	19.81	8.86375	0	0	1	0
2x64	Lig	Shared	4.09	5.42875	0	0	1	0
2x64	E1x47	Shared	3.71	2.5525	0	0	1	2
2x56	3x32	s1p1_off	1.61	0	0	0	2	1
2x57	7x38	s1p1_on	0	6.5925	0	1	2	1
2x60	3x32	s1p1_on	0	5.61125	1	1	1	1
2x63	3x28	s1p1_on	0	3.49	0	0	2	1
E1x50	E1x501	s1p1_on	0	3.435	0	1	2	2
3x29	E2.L195	s1p1_on	0	5.63625	1	1	1	1
3x29	E2.Y198	s1p1_on	0	6.0325	1	1	1	2
3x37	Lig	s1p1_on	0	6.07125	0	0	1	0
3x40	6x48	s1p1_on	0	4.1375	0	0	2	1
E2.L195	Lig	s1p1_on	0	6.24125	0	1	1	0
5x39	E2.Y198	s1p1_on	0	5.0875	1	1	2	2
5x47	6x48	s1p1_on	0	12.1525	0	1	1	1
5x47	Lig	s1p1_on	0	5.53125	0	1	1	0
6x48	Lig	s1p1_on	0	4.40125	4	1	1	0
6x51	Lig	s1p1_on	0	4.6975	0	0	1	0
6x55	Lig	s1p1_on	0	4.555	0	0	1	0
7x35	7x36	s1p1_on	0	4.6275	0	0	1	2
2x57	7x35	s1p1_on	0	1.6825	0	1	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	s1p1_off	3V2Y-S1P₁-PubChem 51892645
	s1p1_on	7TD3-S1P₁-S1P-Gi1/&β;1/&γ;2 7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P₁-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P₁-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P₁-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P₁-PubChem 4077460-Gi1/&β;1/&γ;2

Network Difference
Value	s1p1_off	s1p1_on
I_min	4.11	3.16125
Number of Linked Nodes	263	297
Number of Specific Nodes	11 (4.18%)	45 (15.15%)
Number of Shared Nodes	252 (95.82%)	252 (84.85%)
Number of Links	277	327
Number of Specific Links	107 (38.63%)	157 (48.01%)
Number of Shared Links	170 (61.37%)	170 (51.99%)
Number of Hubs	35	48
Number of Specific Hubs	11 (31.43%)	24 (50.00%)
Number of Shared Hubs	24 (68.57%)	24 (50.00%)
Average % Shared Neighbours (Jaccard)	39.26
Average % Shared Neighbours (Otsuka)	47.42
Average % Shared Neighbours (Overlap Coefficient)	55.71
Average % Shared Cliques (k3-6)	54.84
Graphlets Similarity	0.605322

Paths Difference
Value	s1p1_off	s1p1_on
Number Of Nodes in MetaPath	62	48
Specific Nodes in MetaPath	31 (50.00%)	17 (35.42%)
Shared Nodes in MetaPath	252 (95.82%)	252 (95.82%)
Number Of Links MetaPath	67	51
Specific Links in MetaPath	45 (67.16%)	29 (56.86%)
Shared Links in MetaPath	170 (61.37%)	170 (61.37%)
Number of Shortest Paths	55906	89224
Length Of Smallest Path	3	3
Average Path Length	13.7277	12.9627
Length of Longest Path	26	26
Minimum Path Strength	1.235	0.343125
Average Path Strength	7.61905	5.32288
Maximum Path Strength	20.275	17.9131
Minimum Path Correlation	0.7	0.70125
Average Path Correlation	0.926894	0.919237
Maximum Path Correlation	0.99	0.99375
Minimum % Of Corr. Nodes	5.26316	4.54545
Average % Of Corr. Nodes	52.4508	47.8954
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	42.2499	53.5667
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

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